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Aliases for SLC1A6 Gene

Aliases for SLC1A6 Gene

  • Solute Carrier Family 1 Member 6 2 3 4
  • Solute Carrier Family 1 (High Affinity Aspartate/Glutamate Transporter), Member 6 2 3 5
  • Sodium-Dependent Glutamate/Aspartate Transporter 3 4
  • EAAT4 3 4

External Ids for SLC1A6 Gene

Previous GeneCards Identifiers for SLC1A6 Gene

  • GC19M015440
  • GC19M014906
  • GC19M015060
  • GC19M014628

Summaries for SLC1A6 Gene

GeneCards Summary for SLC1A6 Gene

SLC1A6 (Solute Carrier Family 1 Member 6) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neurotransmitter Release Cycle. GO annotations related to this gene include L-glutamate transmembrane transporter activity and L-aspartate transmembrane transporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A6 Gene

  • Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium.

Tocris Summary for SLC1A6 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.

Gene Wiki entry for SLC1A6 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A6 Gene

Genomics for SLC1A6 Gene

Regulatory Elements for SLC1A6 Gene

Genomic Location for SLC1A6 Gene

Chromosome:
19
Start:
14,950,033 bp from pter
End:
15,022,990 bp from pter
Size:
72,958 bases
Orientation:
Minus strand

Genomic View for SLC1A6 Gene

Genes around SLC1A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A6 Gene

Proteins for SLC1A6 Gene

  • Protein details for SLC1A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48664-EAA4_HUMAN
    Recommended name:
    Excitatory amino acid transporter 4
    Protein Accession:
    P48664
    Secondary Accessions:
    • Q8N753

    Protein attributes for SLC1A6 Gene

    Size:
    564 amino acids
    Molecular mass:
    61565 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC1A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A6 Gene

Proteomics data for SLC1A6 Gene at MOPED

Post-translational modifications for SLC1A6 Gene

  • Glycosylation at Asn 216, Asn 232, and Asn 239
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC1A6 Gene

Domains & Families for SLC1A6 Gene

Gene Families for SLC1A6 Gene

Protein Domains for SLC1A6 Gene

Suggested Antigen Peptide Sequences for SLC1A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48664

UniProtKB/Swiss-Prot:

EAA4_HUMAN :
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A6 subfamily.
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A6 subfamily.
genes like me logo Genes that share domains with SLC1A6: view

Function for SLC1A6 Gene

Molecular function for SLC1A6 Gene

GENATLAS Biochemistry:
solute carrier family 1,member 6 (high affinity aspartate/glutamate transport)
UniProtKB/Swiss-Prot Function:
Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium.

Gene Ontology (GO) - Molecular Function for SLC1A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005314 high-affinity glutamate transmembrane transporter activity TAS --
GO:0017153 sodium:dicarboxylate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A6: view
genes like me logo Genes that share phenotypes with SLC1A6: view

Animal Models for SLC1A6 Gene

MGI Knock Outs for SLC1A6:

Animal Model Products

CRISPR Products

miRNA for SLC1A6 Gene

miRTarBase miRNAs that target SLC1A6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC1A6 Gene

Localization for SLC1A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A6 Gene COMPARTMENTS Subcellular localization image for SLC1A6 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLC1A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,TAS 7791878
genes like me logo Genes that share ontologies with SLC1A6: view

Pathways & Interactions for SLC1A6 Gene

genes like me logo Genes that share pathways with SLC1A6: view

Interacting Proteins for SLC1A6 Gene

Gene Ontology (GO) - Biological Process for SLC1A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport IEA --
GO:0015810 aspartate transport TAS 7791878
GO:0055085 transmembrane transport IEA --
GO:0089711 L-glutamate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC1A6: view

No data available for SIGNOR curated interactions for SLC1A6 Gene

Drugs & Compounds for SLC1A6 Gene

(5) Drugs for SLC1A6 Gene - From: IUPHAR, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
[<sup>3</sup>H]D-aspartic acid Pharma 0
[<sup>3</sup>H]L-aspartic acid Pharma 0
DL-TBOA Pharma Inhibition, Inhibitor 0
threo-3-methylglutamate Pharma Inhibition, Inhibitor 0

(10) Additional Compounds for SLC1A6 Gene - From: IUPHAR, Tocris, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]ETB-TBOA
sodium
  • Sodium
  • Sodium ion
7440-23-5
7-Chlorokynurenic acid
18000-24-3
cis-ACBD
73550-55-7
Dihydrokainic acid
52497-36-6

(5) Tocris Compounds for SLC1A6 Gene

Compound Action Cas Number
7-Chlorokynurenic acid Potent competitive inhibitor of L-glutamate uptake 18000-24-3
cis-ACBD Potent, selective L-glutamate uptake inhibitor 73550-55-7
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake 52497-36-6
L-(-)-threo-3-Hydroxyaspartic acid Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 7298-99-9
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 64769-66-0
genes like me logo Genes that share compounds with SLC1A6: view

Transcripts for SLC1A6 Gene

Unigene Clusters for SLC1A6 Gene

Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for SLC1A6 Gene

GeneLoc Exon Structure for
SLC1A6
ECgene alternative splicing isoforms for
SLC1A6

Expression for SLC1A6 Gene

mRNA expression in normal human tissues for SLC1A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC1A6 Gene

This gene is overexpressed in Brain - Cerebellum (x16.6), Brain - Cerebellar Hemisphere (x8.0), and Testis (x4.4).

Protein differential expression in normal tissues from HIPED for SLC1A6 Gene

This gene is overexpressed in Brain (48.0), Lung (12.4), and Fetal Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC1A6 Gene



SOURCE GeneReport for Unigene cluster for SLC1A6 Gene Hs.515217

mRNA Expression by UniProt/SwissProt for SLC1A6 Gene

P48664-EAA4_HUMAN
Tissue specificity: Brain. Expressed densely and selectively in cell bodies of Purkinje cells.
genes like me logo Genes that share expression patterns with SLC1A6: view

Protein tissue co-expression partners for SLC1A6 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC1A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC1A6 35
  • 90.72 (n)
  • 96.28 (a)
SLC1A6 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A6 35
  • 90.84 (n)
  • 96.63 (a)
SLC1A6 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a6 35
  • 88 (n)
  • 95.54 (a)
Slc1a6 16
Slc1a6 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a6 35
  • 87.34 (n)
  • 95.01 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC1A6 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SLC1A6 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC1A6 35
  • 73.72 (n)
  • 76.75 (a)
SLC1A6 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494506 35
  • 66.67 (n)
  • 71.91 (a)
zebrafish
(Danio rerio)
Actinopterygii slc1a6 35
  • 65.51 (n)
  • 66.85 (a)
slc1a6 36
  • 65 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 37
  • 45 (a)
Eaat2 37
  • 41 (a)
Eaat1 35
  • 54.5 (n)
  • 48.96 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009443 35
  • 56.63 (n)
  • 48.28 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-2 37
  • 49 (a)
K08F4.4 37
  • 44 (a)
R05G6.6 37
  • 39 (a)
T22E5.2 37
  • 46 (a)
W03G1.1 37
  • 35 (a)
Y53C12A.2 37
  • 45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7013 35
Species with no ortholog for SLC1A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A6 Gene

ENSEMBL:
Gene Tree for SLC1A6 (if available)
TreeFam:
Gene Tree for SLC1A6 (if available)

Paralogs for SLC1A6 Gene

Paralogs for SLC1A6 Gene

genes like me logo Genes that share paralogs with SLC1A6: view

Variants for SLC1A6 Gene

Sequence variations from dbSNP and Humsavar for SLC1A6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1089 -- 15,006,026(+) CTCAC(A/G)TGAGG intron-variant
rs735622 -- 14,992,972(+) ATTAA(A/G)GGAGA intron-variant
rs739961 -- 14,974,498(-) TAGAC(A/G)GATGG intron-variant, upstream-variant-2KB
rs739962 -- 14,974,520(-) TACAC(A/G)TGAGG intron-variant, upstream-variant-2KB
rs739963 -- 14,974,728(-) aaaac(A/G)tataa intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC1A6 Gene

Variant ID Type Subtype PubMed ID
nsv911129 CNV Loss 21882294
nsv510756 CNV Loss 20534489
nsv2424 CNV Loss 18451855

Variation tolerance for SLC1A6 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC1A6 Gene

HapMap Linkage Disequilibrium report
SLC1A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A6 Gene

Disorders for SLC1A6 Gene

Relevant External Links for SLC1A6

Genetic Association Database (GAD)
SLC1A6
Human Genome Epidemiology (HuGE) Navigator
SLC1A6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC1A6

No disorders were found for SLC1A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC1A6 Gene

Publications for SLC1A6 Gene

  1. An excitatory amino-acid transporter with properties of a ligand- gated chloride channel. (PMID: 7791878) Fairman W.A. … Amara S.G. (Nature 1995) 2 3 4 67
  2. Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype. (PMID: 9838098) Lin C.L. … Rothstein J.D. (Brain Res. Mol. Brain Res. 1998) 23 25 26
  3. High affinity glutamate transporters: regulation of expression and activity. (PMID: 9224806) Gegelashvili G. … Schousboe A. (Mol. Pharmacol. 1997) 23 25 26
  4. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. (PMID: 17221839) Deng X. … Fukumaki Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23
  5. EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase. (PMID: 17442044) Rajamanickam J. … Boehmer C. (J. Neurochem. 2007) 3 23

Products for SLC1A6 Gene

Sources for SLC1A6 Gene

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