Aliases for SLC1A6 Gene
External Ids for SLC1A6 Gene
Previous GeneCards Identifiers for SLC1A6 Gene
GeneCards Summary for SLC1A6 Gene
SLC1A6 (Solute Carrier Family 1 (High Affinity Aspartate/Glutamate Transporter), Member 6) is a Protein Coding gene. Diseases associated with SLC1A6 include early myoclonic encephalopathy and traumatic brain injury. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include L-glutamate transmembrane transporter activity and L-aspartate transmembrane transporter activity. An important paralog of this gene is SLC1A3.
UniProtKB/Swiss-Prot for SLC1A6 Gene
Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.