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GIFtS

SLC1A6 Gene

protein-coding   GIFtS: 63
GCID: GC19M015060

solute carrier family 1 (high affinity aspartate/glutamate...
 Explore 13 diseases affiliated with
SLC1A6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC1A6    

Aliases
for SLC1A6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 1 (High Affinity Aspartate/Glutamate Transporter),
Member 61 2
EAAT41 2 3
Sodium-Dependent Glutamate/Aspartate Transporter2 3
Solute Carrier Family 1 Member 62 3
Excitatory Amino Acid Transporter 42

External Ids:    HGNC: 109441   Entrez Gene: 65112   Ensembl: ENSG000001051437   OMIM: 6006375   UniProtKB: P486643   

Export aliases for SLC1A6 gene to outside databases

Previous GC identifers: GC19M015440 GC19M014906 GC19M014921 GC19M014628


Summaries
for SLC1A6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: EAA4_HUMAN, P48664
Function: Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium

summary for SLC1A6:
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and
potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the
brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia),
EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low
ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for
metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated
in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia
and traumatic brain injury.

Gene Wiki entry for SLC1A6 (Excitatory amino-acid transporter 4)


Genomic Views
for SLC1A6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC1A6 gene promoter:
         TBP   SREBP-1c   E47   SREBP-1b   c-Ets-1   HEN1   PPAR-gamma1   SREBP-1a   Chx10   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC1A6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC1A6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC1A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13

SLC1A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC1A6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015060:  view genomic region     (about GC identifiers)

Start:
 15,060,846 bp from pter      End:
 15,121,432 bp from pter
Size:
 60,587 bases      Orientation:
 minus strand

Proteins
for SLC1A6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EAA4_HUMAN, P48664 (See protein sequence)
Recommended Name: Excitatory amino acid transporter 4  
Size: 564 amino acids; 61565 Da
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SLC1A6: NX_P48664

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48664

    • SLC1A6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001259016.1  NP_001259017.1  NP_005062.1  

    ENSEMBL proteins: 
     ENSP00000409386   ENSP00000221742   ENSP00000446175  
    Reactome Protein details: P48664
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    Uscn Proteins for SLC1A6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7791878
    GO:0016020membrane TAS7791878


    SLC1A6 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC1A6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC1A6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001991 Na-dicarboxylate_symporter
     IPR018107 Na-dicarboxylate_symporter_CS

    Graphical View of Domain Structure for InterPro Entry P48664

    ProtoNet protein and cluster: P48664

    1 Blocks protein family: IPB001991 Sodium:dicarboxylate symporter

    UniProtKB/Swiss-Prot: EAA4_HUMAN, P48664
    Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A6 subfamily


    Function
    for SLC1A6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EAA4_HUMAN, P48664
    Function: Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium

         Genatlas biochemistry entry for SLC1A6:
    solute carrier family 1,member 6 (high affinity aspartate/glutamate transport)

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005313L-glutamate transmembrane transporter activity IEA--
    GO:0015183L-aspartate transmembrane transporter activity TAS7791878
    GO:0017153sodium:dicarboxylate symporter activity IEA--


    SLC1A6 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC1A6:
     Decreased Wnt reporter activit  Large cells 

    Animal Models:
         Mouse knock-out Slc1a6tm1Dbe for SLC1A6
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Slc1a6):
     nervous system 

    SLC1A6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC1A6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    4GABA synthesis, release, reuptake and degradation
    		Neurotransmitter Release Cycle0.53
    5Serotonin Neurotransmitter Release Cycle
    		Glutamate Neurotransmitter Release Cycle0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for SLC1A6 (see all 8)
        Glutamate Neurotransmitter Release Cycle
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transmission across Chemical Synapses
    Amino acid and oligopeptide SLC transporters


    1         Kegg Pathway  (Kegg details for SLC1A6):
        Glutamatergic synapse


    SLC1A6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC1A6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for SLC1A6 (P486643 ENSP000002217424) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF11O150853, ENSP000003571774I2D: score=2 STRING: ENSP00000357177
    ARIH2O953763I2D: score=4 
    FTH1P027943I2D: score=1 
    KRTAP4-12Q9BQ663I2D: score=1 
    MDFIQ997503I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0007268synaptic transmission TAS7791878
    GO:0015810aspartate transport TAS7791878
    GO:0015813L-glutamate transport TAS7791878
    GO:0042391regulation of membrane potential IEA--


    SLC1A6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC1A6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC1A6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLC1A6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor[64769-66-0]
    DL-TBOASelective non-transportable inhibitor of EAATs--
    L-CCG-lll Potent, competitive glutamate uptake inhibitor [117857-95-1]
    7-Chlorokynurenic acidPotent competitive inhibitor of L-glutamate uptake[18000-24-3]
    L-(-)-threo-3-Hydroxyaspartic acidTransportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor[7298-99-9]

    1 HMDB Compound for SLC1A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC1A6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--9838098 17139284 9224806 17016423

    3 Novoseek chemical compound relationships for SLC1A6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 70.7 46 20110679 (3), 11242047 (3), 10812201 (3), 10963969 (2) (see all 23)
    chloride 44.2 4 9838098 (1), 9330365 (1)
    aspartate 36.7 4 9224806 (1), 19289926 (1), 18540911 (1), 10812201 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC1A6 / EAA4 

    Transcripts
    for SLC1A6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC1A6 gene (3 alternative transcripts): 
    NM_001272087.1  NM_001272088.1  NM_005071.2  

    Unigene Cluster for SLC1A6:

    Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
    Hs.515217  [show with all ESTs]
    Unigene Representative Sequence: AB209199
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430939(uc010xod.1) ENST00000221742(uc002naa.1 uc010dzu.1 uc002nad.1)
    ENST00000544886(uc002nab.3 uc002nac.3)

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    Clone
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    Additional cDNA sequence: 

    AB209199.1 AK302380.1 AK312996.1 BC028721.2 BC040604.1 U18244.1 

    5 DOTS entries:

    DT.97764338  DT.210147  DT.121503564  DT.97820049  DT.95265185 

    24/30 AceView cDNA sequences (see all 30):

    AA351028 BC028721 BX284034 BG697829 AW298350 BI915531 BC040604 AI243717 
    BI919070 BI463517 BM727027 BM808606 U18244 BX452033 AI127656 BE551895 
    BI829415 AI024433 Z40963 NM_005071 F07883 H23171 AL536224 BI460854 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A6 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                      -                           
    SP2:              -     -     -     -                                                                                 
    SP3:              -     -     -     -                                                                                 
    SP4:                    -     -     -                                                                                 
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for SLC1A6

    Expression
    for SLC1A6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC1A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCAAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC1A6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC1A6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC1A6

    SOURCE GeneReport for Unigene cluster: Hs.515217

    UniProtKB/Swiss-Prot: EAA4_HUMAN, P48664
    Tissue specificity: Brain. Expressed densely and selectively in cell bodies of Purkinje cells

        SABiosciences Expression via Pathway-Focused PCR Array including SLC1A6: 
              GABA & Glutamate in human mouse rat

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    In Situ
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    Orthologs
    for SLC1A6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC1A6 gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC1A61 solute carrier family 1 (high affinity aspartate/glutamate more 73.79(n)
    76.75(a)    		   420057  XM_418178.2  XP_418178.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii slc1a61 solute carrier family 1 (high affinity aspartate/glutamate more 65.87(n)
    67.22(a)    		   559270  NM_001109703.1  NP_001103173.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eaat13 sodium/excitatory glutamate cotransporter 45(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea glt-23 excitatory amino acid transporter 49(a)
    (best of 6)    		   X(3531387-3534184)   --
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gltP6
    dctA6
    (see all 3)    		 glutamate/aspartate:proton symporter
    C4-dicarboxylic acid, orotate and citrate transpor...
    (see all 3)    		 26(a)
    24(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 Chromosome(4292504-4293817)
    Chromosome(3680184-3681470)


    ENSEMBL Gene Tree for SLC1A6 (if available)
    TreeFam Gene Tree for SLC1A6 (if available) 

    Paralogs
    for SLC1A6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC1A6 gene
    SLC1A32  SLC1A52  SLC1A72  SLC1A12  SLC1A22  SLC1A42  
    6 SIMAP similar genes for SLC1A6 using alignment to 9 protein entries:     EAA4_HUMAN (see all proteins):
    SLC1A3    SLC1A7    SLC1A2    SLC1A1    SLC1A4    SLC1A5

    SLC1A6 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC1A6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/506 NCBI SNPs in SLC1A6 are shown (see all 506)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1424693661,2
    		--15060496(+) CTCATA/GATCTG 1 -- ds50010--------
    rs730113091,2
    		C,--15060755(+) CTCCCC/GAAACC 1 -- ds50013Minor allele frequency- G:0.13NA EA 242
    rs1439778561,2
    		--15060771(+) GAAACA/GTTTCT 1 -- ds50010--------
    rs1904170201,2
    		--15060796(+) CACGCC/TGTCCT 1 -- ds50010--------
    rs1487700801,2
    		--15060797(+) ACGCCA/GTCCTT 1 -- ds50010--------
    rs1424197931,2
    		--15060859(+) TTCCTC/GCTCCT 1 -- ds50010--------
    rs58272641,2
    		C,--15060984(+) TCTCTG/-GGGGG 1 -- ds50012Minor allele frequency- -:0.00NA 4
    rs1459259711,2
    		F--15061022(+) CTCTCG/ATTGCC 2 /N syn11Minor allele frequency- A:0.00NA 4294
    rs1399731181,2
    		F--15061129(+) CTCCCG/ACTGAG 2 /R /W mis11Minor allele frequency- A:0.00NA 4552
    rs1467536761,2
    		C--15061155(+) CGGCCG/ACTCCA 2 /A /V mis11Minor allele frequency- A:0.00NA 4548

    HapMap Linkage Disequilibrium report for SLC1A6 (15060846 - 15121432 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC1A6
         1 CNV: 35611

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    Disorders / Diseases
    for SLC1A6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC1A6 for disorders           About GeneDecksing

    OMIM gene information: 600637    OMIM disorders: --

    13 diseases for SLC1A6:    About MalaCards
    traumatic brain injury    brain injury    ischemia    ossifying fibromyxoid tumor
    schizophrenia    canavan disease    neuronitis    spinocerebellar ataxia
    seizures    ataxia    retinitis    tuberculosis
    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for SLC1A6:
    Early myoclonic encephalopathy     Canavan disease
    Human Genome Epidemiology (HuGE) Navigator: SLC1A6 (4 documents)

    Export disorders for SLC1A6 gene to outside databases

    Publications
    for SLC1A6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC1A6 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with SLC1A6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An excitatory amino-acid transporter with properties of a ligand- gated chloride channel. (PubMed id 7791878)1, 2, 3 Fairman W.A....Amara S.G. (1995)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase. (PubMed id 17442044)1, 9 Rajamanickam J....Boehmer C. (2007)
    4. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. (PubMed id 11242047)1, 9 Jackson M....Rothstein J.D. (2001)
    5. Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype. (PubMed id 9838098)7, 9 Lin C.L....Rothstein J.D. (1998)
    6. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. (PubMed id 17221839)1, 9 Deng X....Fukumaki Y. (2007)
    7. High affinity glutamate transporters: regulation of expression and activity. (PubMed id 9224806)7, 9 Gegelashvili G. and Schousboe A. (1997)
    8. Neuronal glutamate transporters regulate glial excitat ory transmission. (PubMed id 22302796)1 Tsai M.C....Wadiche J.I. (2012)
    9. Substrate-dependent gating of anion channels associat ed with excitatory amino acid transporter 4. (PubMed id 21572047)1 Machtens J.P....Fahlke C. (2011)
    10. A conserved aspartate determines pore properties of a nion channels associated with excitatory amino acid transporter 4 (EAAT4). (PubMed id 20519505)1 Kovermann P....Fahlke C. (2010)

    External Searches for SLC1A6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC1A6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6511 HGNC: 10944 AceView: SLC1A6 Ensembl:ENSG00000105143 euGenes: HUgn6511
    ECgene: SLC1A6 Kegg: 6511 H-InvDB: SLC1A6

    Other Databases showing SLC1A6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC1A6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC1A6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC1A6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC1A6 gene:
    Search GeneIP for patents involving SLC1A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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