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Aliases for SLC1A5 Gene

Aliases for SLC1A5 Gene

  • Solute Carrier Family 1 Member 5 2 3 4 5
  • Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5 2 3
  • Sodium-Dependent Neutral Amino Acid Transporter Type 2 3 4
  • RD114/Simian Type D Retrovirus Receptor 3 4
  • Baboon M7 Virus Receptor 3 4
  • ATB(0) 3 4
  • ASCT2 3 4
  • M7V1 3 4
  • RDRC 3 4
  • Neutral Amino Acid Transporter B(0) 3
  • Neutral Amino Acid Transporter B 3
  • RD114 Virus Receptor 3
  • M7VS1 3
  • AAAT 3
  • ATBO 3
  • R16 3
  • RDR 4

External Ids for SLC1A5 Gene

Previous HGNC Symbols for SLC1A5 Gene

  • RDRC
  • M7V1

Previous GeneCards Identifiers for SLC1A5 Gene

  • GC19M047922
  • GC19M047669
  • GC19M051954
  • GC19M051969
  • GC19M047278
  • GC19M043702

Summaries for SLC1A5 Gene

Entrez Gene Summary for SLC1A5 Gene

  • The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC1A5 Gene

SLC1A5 (Solute Carrier Family 1 Member 5) is a Protein Coding gene. Diseases associated with SLC1A5 include Lacrimal Gland Adenocarcinoma. Among its related pathways are Collagen chain trimerization and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC1A4.

UniProtKB/Swiss-Prot for SLC1A5 Gene

  • Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).

  • (Microbial infection) Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.

Gene Wiki entry for SLC1A5 Gene

Additional gene information for SLC1A5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A5 Gene

Genomics for SLC1A5 Gene

Regulatory Elements for SLC1A5 Gene

Enhancers for SLC1A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H047242 2.1 FANTOM5 Ensembl ENCODE dbSUPER 33.9 -455.1 -455142 2 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF548 SP3 MCM3 ZC3H11A MEF2D ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 NOP53 ENSG00000269321 SLC1A5 INAFM1 SNORD23
GH19H047239 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.6 -451.9 -451911 3 HDGF PKNOX1 ARNT ZFP64 ARID4B YBX1 ZNF2 ZBTB7B ZNF207 ZNF548 ZC3H4 BICRA ENSG00000268810 NOP53 NOP53-AS1 CCDC9 INAFM1 ENSG00000268746 SLC1A5 EHD2
GH19H046782 1.4 ENCODE dbSUPER 25 +2.9 2868 6 MLX FEZF1 DMAP1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 ZC3H4 CCDC61 BICRA PRKD2 CCDC9 NOP53-AS1 SLC1A5 ENSG00000268810 SYMPK SNORD23
GH19H047225 1.5 ENCODE dbSUPER 22.8 -440.7 -440733 8 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 NOP53 ENSG00000269321 PPP5D1 ENSG00000269124 SNORD23
GH19H046859 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -74.8 -74786 8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000268810 ZC3H4 ARHGAP35 SLC1A5 ENSG00000269124 BICRA TMEM160 CCDC61 CCDC9 PPP5C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC1A5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC1A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000288743 1149 2601 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS

Genomic Location for SLC1A5 Gene

Chromosome:
19
Start:
46,759,698 bp from pter
End:
46,788,649 bp from pter
Size:
28,952 bases
Orientation:
Minus strand

Genomic View for SLC1A5 Gene

Genes around SLC1A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A5 Gene

Proteins for SLC1A5 Gene

  • Protein details for SLC1A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15758-AAAT_HUMAN
    Recommended name:
    Neutral amino acid transporter B(0)
    Protein Accession:
    Q15758
    Secondary Accessions:
    • A8K9H5
    • B4DR77
    • B4DWS4
    • B7ZB81
    • D0EYG6
    • E9PC01
    • O95720
    • Q96RL9
    • Q9BWQ3
    • Q9UNP2

    Protein attributes for SLC1A5 Gene

    Size:
    541 amino acids
    Molecular mass:
    56598 Da
    Quaternary structure:
    • Homotrimer (Probable). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904).

    Three dimensional structures from OCA and Proteopedia for SLC1A5 Gene

    Alternative splice isoforms for SLC1A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A5 Gene

Post-translational modifications for SLC1A5 Gene

  • Ubiquitination at Lys372, isoforms=2, 3502, isoforms=2, 3522, and Lys537
  • Glycosylation at isoforms=163 and Asn212
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC1A5 (SLC1A5)

No data available for DME Specific Peptides for SLC1A5 Gene

Domains & Families for SLC1A5 Gene

Gene Families for SLC1A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC1A5 Gene

Graphical View of Domain Structure for InterPro Entry

Q15758

UniProtKB/Swiss-Prot:

AAAT_HUMAN :
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
Family:
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
genes like me logo Genes that share domains with SLC1A5: view

Function for SLC1A5 Gene

Molecular function for SLC1A5 Gene

GENATLAS Biochemistry:
solute carrier family 1 (glutamate/neutral amino acid transport),member 5
UniProtKB/Swiss-Prot Function:
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.

Phenotypes From GWAS Catalog for SLC1A5 Gene

Gene Ontology (GO) - Molecular Function for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 10051606
GO:0005515 protein binding IPI 23492904
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015175 neutral amino acid transmembrane transporter activity TAS 10051606
genes like me logo Genes that share ontologies with SLC1A5: view
genes like me logo Genes that share phenotypes with SLC1A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC1A5

CRISPR Products

miRNA for SLC1A5 Gene

miRTarBase miRNAs that target SLC1A5

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC1A5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC1A5 Gene

Localization for SLC1A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A5 Gene

Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC1A5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8702519
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with SLC1A5: view

Pathways & Interactions for SLC1A5 Gene

genes like me logo Genes that share pathways with SLC1A5: view

Gene Ontology (GO) - Biological Process for SLC1A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006865 amino acid transport TAS --
GO:0006868 glutamine transport TAS 21757002
GO:0010585 glutamine secretion IEA --
GO:0015804 neutral amino acid transport TAS 10051606
genes like me logo Genes that share ontologies with SLC1A5: view

No data available for SIGNOR curated interactions for SLC1A5 Gene

Drugs & Compounds for SLC1A5 Gene

(7) Drugs for SLC1A5 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra Target 0
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Transporter, substrate 0
benzylcysteine Experimental Pharma Inhibition, Inhibitor 0
benzylserine Pharma Inhibition, Inhibitor 0

(3) Additional Compounds for SLC1A5 Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
p-nitrophenyl glutamyl anilide
Inhibition, Inhibitor
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC1A5: view

Transcripts for SLC1A5 Gene

mRNA/cDNA for SLC1A5 Gene

(4) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC1A5 Gene

Solute carrier family 1 (neutral amino acid transporter), member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC1A5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2:
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for SLC1A5 Gene

GeneLoc Exon Structure for
SLC1A5
ECgene alternative splicing isoforms for
SLC1A5

Expression for SLC1A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC1A5 Gene

Protein differential expression in normal tissues from HIPED for SLC1A5 Gene

This gene is overexpressed in Nasal epithelium (29.9), Bone (11.7), and Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC1A5 Gene



Protein tissue co-expression partners for SLC1A5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC1A5 Gene:

SLC1A5

SOURCE GeneReport for Unigene cluster for SLC1A5 Gene:

Hs.631582

mRNA Expression by UniProt/SwissProt for SLC1A5 Gene:

Q15758-AAAT_HUMAN
Tissue specificity: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Evidence on tissue expression from TISSUES for SLC1A5 Gene

  • Kidney(4.5)
  • Intestine(4.3)
  • Nervous system(3.5)
  • Lung(3.3)
  • Eye(2.8)
  • Skin(2.4)
  • Liver(2.3)
  • Blood(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with SLC1A5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC1A5 Gene

Orthologs for SLC1A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A5 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia SLC1A5 33 34
  • 86.17 (n)
cow
(Bos Taurus)
Mammalia SLC1A5 33 34
  • 84.88 (n)
mouse
(Mus musculus)
Mammalia Slc1a5 33 16 34
  • 81.29 (n)
rat
(Rattus norvegicus)
Mammalia Slc1a5 33
  • 79.38 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC1A5 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A5 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A5 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a5 33
  • 69.29 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535841 33
  • 67.18 (n)
slc1a5 34 34
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 35 34
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-4 34
  • 35 (a)
OneToMany
W03G1.1 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for SLC1A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A5 Gene

ENSEMBL:
Gene Tree for SLC1A5 (if available)
TreeFam:
Gene Tree for SLC1A5 (if available)

Paralogs for SLC1A5 Gene

Paralogs for SLC1A5 Gene

(6) SIMAP similar genes for SLC1A5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC1A5: view

Variants for SLC1A5 Gene

Sequence variations from dbSNP and Humsavar for SLC1A5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000024738 -- 46,766,702(+) GAATG(G/T)CAGAG intron-variant
rs1000073043 -- 46,773,124(+) CCACT(A/G)TTCTG intron-variant
rs1000124943 -- 46,772,998(+) TCACC(A/G)TATTA intron-variant
rs1000219537 -- 46,767,066(+) AAGGA(-/G)GGCGT intron-variant
rs1000404039 -- 46,760,437(+) AAATT(G/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A5 Gene

Variant ID Type Subtype PubMed ID
dgv3608n100 CNV gain 25217958
esv1008167 CNV deletion 20482838
esv3893223 CNV gain 25118596
esv3893224 CNV gain 25118596
nsv1065221 CNV gain 25217958
nsv833850 CNV loss 17160897

Variation tolerance for SLC1A5 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC1A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC1A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A5 Gene

Disorders for SLC1A5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC1A5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC1A5

Genetic Association Database (GAD)
SLC1A5
Human Genome Epidemiology (HuGE) Navigator
SLC1A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC1A5
genes like me logo Genes that share disorders with SLC1A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC1A5 Gene

Publications for SLC1A5 Gene

  1. The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. (PMID: 10051606) Rasko JE … Miller AD (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 60
  2. Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (PMID: 8702519) Kekuda R … Ganapathy V (The Journal of biological chemistry 1996) 2 3 4 22 60
  3. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. (PMID: 18638388) Deng X … Fukumaki Y (BMC psychiatry 2008) 3 22 45 60
  4. Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. (PMID: 11350958) Tailor CS … Kabat D (The Journal of biological chemistry 2001) 3 4 22 60
  5. A novel human endogenous retroviral protein inhibits cell-cell fusion. (PMID: 23492904) Sugimoto J … Schust D (Scientific reports 2013) 3 4 60

Products for SLC1A5 Gene

Sources for SLC1A5 Gene

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