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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC1A5 Gene

protein-coding   GIFtS: 66
GCID: GC19M047278

solute carrier family 1 (neutral amino acid transporter),...


(Previous symbols: RDRC, M7V1)
 Explore 15 diseases affiliated with
SLC1A5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC1A5    

Aliases
for SLC1A5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 51 2     RD114/Simian Type D Retrovirus Receptor2 3
M7V11 2 3 5     M7VS12 5
RDRC1 2 3 5     ATBO2
ASCT21 2 3     R162
AAAT1 2     Neutral Amino Acid Transporter B2
Baboon M7 Virus Receptor2 3     Neutral Amino Acid Transporter B(0)2
Sodium-Dependent Neutral Amino Acid Transporter Type 22 3     RD114 Virus Receptor2
Solute Carrier Family 1 Member 52 3     RDR3
ATB(0)2 3     

External Ids:    HGNC: 109431   Entrez Gene: 65102   Ensembl: ENSG000001052817   OMIM: 1091905   UniProtKB: Q157583   

Export aliases for SLC1A5 gene to outside databases

Previous GC identifers: GC19M047922 GC19M047669 GC19M051954 GC19M051969 GC19M043702


Summaries
for SLC1A5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC1A5:
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D
retrovirus (Larriba et al., 2001 (PubMed 11781704)).(supplied by OMIM, Jan 2011)

UniProtKB/Swiss-Prot: AAAT_HUMAN, Q15758
Function: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It
accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino
acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Acts as a cell surface
receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses

Gene Wiki entry for SLC1A5


Genomic Views
for SLC1A5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC1A5 gene promoter:
         SRF   GR   N-Myc   SRF (504 AA)   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC1A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC1A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC1A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

SLC1A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC1A5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047278:  view genomic region     (about GC identifiers)

Start:
 47,278,140 bp from pter      End:
 47,291,842 bp from pter
Size:
 13,703 bases      Orientation:
 minus strand

Proteins
for SLC1A5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AAAT_HUMAN, Q15758 (See protein sequence)
Recommended Name: Neutral amino acid transporter B(0)  
Size: 541 amino acids; 56598 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable). Melanosome. Note=Identified by mass
spectrometry in melanosome fractions from stage I to stage IV
Secondary accessions: A8K9H5 D0EYG6 O95720 Q96RL9 Q9BWQ3 Q9UNP2
Alternative initiation: 1 isoform:  Q15758-1   

Explore the universe of human proteins at neXtProt for SLC1A5: NX_Q15758

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15758

    • SLC1A5 Protein expression data from MOPED and PaxDb:    About this image 
    SLC1A5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138616.1  NP_001138617.1  NP_005619.1  

    ENSEMBL proteins: 
     ENSP00000444408   ENSP00000406532   ENSP00000397924  
    Reactome Protein details: Q15758
    Human Recombinant Protein Products for SLC1A5: 
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    Uscn Proteins for SLC1A5

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8702519
    GO:0016020membrane TAS8702519

    SLC1A5 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC1A5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC1A5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001991 Na-dicarboxylate_symporter
     IPR018107 Na-dicarboxylate_symporter_CS

    Graphical View of Domain Structure for InterPro Entry Q15758

    ProtoNet protein and cluster: Q15758

    1 Blocks protein family: IPB001991 Sodium:dicarboxylate symporter

    UniProtKB/Swiss-Prot: AAAT_HUMAN, Q15758
    Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily


    Function
    for SLC1A5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAAT_HUMAN, Q15758
    Function: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It
    accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino
    acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Acts as a cell surface
    receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses

         Genatlas biochemistry entry for SLC1A5:
    solute carrier family 1 (glutamate/neutral amino acid transport),member 5

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10051606
    GO:0015175neutral amino acid transmembrane transporter activity TAS10051606
    GO:0015186L-glutamine transmembrane transporter activity TAS--
    GO:0017153sodium:dicarboxylate symporter activity IEA--
         
    SLC1A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC1A5:
     Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC1A5 

    miRNA
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    hsa-miR-3659 hsa-miR-4324 hsa-miR-137 hsa-miR-122 hsa-miR-634 hsa-miR-2355-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC1A5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for SLC1A5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    		Amino acid transport across the plasma membrane0.63
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00
    4Protein digestion and absorption
    		Protein digestion and absorption1.00
    5Sodium channels and transporters: inward current
    		Sodium channels and transporters: inward current1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLC1A5
        Sodium channels and transporters- inward current


    1 Cell Signaling Technology (CST) Pathway for SLC1A5
        Glucose / Energy Metabolism

    5        Reactome Pathways for SLC1A5
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Amino acid transport across the plasma membrane
    Transport of inorganic cations/anions and amino acids/oligopeptides


    1         Kegg Pathway  (Kegg details for SLC1A5):
        Protein digestion and absorption


    SLC1A5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC1A5

    5/32 Interacting proteins for SLC1A5 (Q157581, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBC1D17Q9HA652, 3MINT-64262 I2D: score=3 
    MAP3K1Q132332, 3MINT-48298 I2D: score=2 
    MPDU1O753521, 3EBI-356576,EBI-1046501 I2D: score=2 
    NEK6Q9HC981, 3EBI-356576,EBI-740364 I2D: score=2 
    TNFRSF1AP194382, 3MINT-49317 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0006868glutamine transport TAS--
    GO:0015804neutral amino acid transport TAS10051606
    GO:0055085transmembrane transport TAS--

    SLC1A5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC1A5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC1A5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC1A5

    3 HMDB Compounds for SLC1A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    SodiumSodium (see all 2)7440-23-5--

    2 DrugBank Compounds for SLC1A5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9transportersubstrate17046712 16516348 16197915 17127344 17094966
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--15581847 17094966

    4 Novoseek chemical compound relationships for SLC1A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 35.1 6 11746424 (2), 17311416 (1)
    alanine 34.2 7 17311416 (3), 11746424 (1)
    glutamate 32.8 3 12372536 (1), 14530974 (1)
    serine 8.26 2 11746424 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC1A5 / AAAT 

    Transcripts
    for SLC1A5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC1A5 gene (3 alternative transcripts): 
    NM_001145144.1  NM_001145145.1  NM_005628.2  

    Unigene Cluster for SLC1A5:

    Solute carrier family 1 (neutral amino acid transporter), member 5
    Hs.631582  [show with all ESTs]
    Unigene Representative Sequence: U53347
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542575(uc002pfs.3) ENST00000434726(uc010xyh.2 uc002pfq.3)
    ENST00000412532(uc002pfr.3)

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    hsa-miR-3659 hsa-miR-4324 hsa-miR-137 hsa-miR-122 hsa-miR-634 hsa-miR-2355-3p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB209738.1 AB593173.1 AF102826.1 AF105230.1 AF105423.1 AF334818.1 AK055630.1 AK125222.1 
    AK292690.1 AK293433.1 AK299137.1 AK301661.1 AK316546.1 BC000062.2 GQ919058.1 U53347.1 

    24/26 DOTS entries (see all 26):

    DT.100031493  DT.100695419  DT.100820760  DT.453708  DT.91833444  DT.100820745  DT.100820757  DT.100820744 
    DT.91769263  DT.100820754  DT.121479977  DT.100820750  DT.100820759  DT.91836751  DT.100820743  DT.91769275 
    DT.95174076  DT.121479951  DT.100820752  DT.100820753  DT.100820761  DT.100820763  DT.121480226  DT.92023889 

    24/602 AceView cDNA sequences (see all 602):

    AL545741 BE783126 BM917256 BQ670238 BQ962681 BQ680859 BM850976 BU159534 
    BM785039 BM783360 BE531331 BX458606 BU857855 BE262194 AI095478 BG328650 
    BM743723 BQ682154 BU957488 BG333262 CN483412 BE336620 AA605241 BM772638 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A5 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b
    SP1:              -     -     -                                                                                 
    SP2:                                                                                                            
    SP3:        -     -     -     -                                                                                 
    SP4:                                -                                                                           
    SP5:                          -                                                                                 


    ECgene alternative splicing isoforms for SLC1A5

    Expression
    for SLC1A5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC1A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACGTCCCA
    SLC1A5 Expression
    About this image

    SLC1A5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC1A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC1A5

    SOURCE GeneReport for Unigene cluster: Hs.631582

    UniProtKB/Swiss-Prot: AAAT_HUMAN, Q15758
    Tissue specificity: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine

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    In Situ
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    Orthologs
    for SLC1A5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC1A5 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SLC1A56
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343566.1(302236-342392)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005358411 neutral amino acid transporter B(0)-like 66.53(n)
    68.78(a)    		   100535841  XM_003200016.1  XP_003200064.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eaat13 sodium/excitatory glutamate cotransporter 38(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea W03G1.13 amino acid transporter 32(a)   IV(531999-533645)   --
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria dctA6
    gltP6
    (see all 3)    		 glutamate/aspartate:proton symporter
    (see all 3)    		 27(a)
    24(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 Chromosome(3680184-3681470)
    Chromosome(4292504-4293817)


    ENSEMBL Gene Tree for SLC1A5 (if available)
    TreeFam Gene Tree for SLC1A5 (if available) 

    Paralogs
    for SLC1A5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC1A5 gene
    SLC1A32  SLC1A72  SLC1A12  SLC1A22  SLC1A42  SLC1A62  
    6 SIMAP similar genes for SLC1A5 using alignment to 7 protein entries:     AAAT_HUMAN (see all proteins):
    SLC1A4    SLC1A1    SLC1A3    SLC1A6    SLC1A2    SLC1A7

    SLC1A5 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC1A5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 NCBI SNPs in SLC1A5 are shown (see all 318)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116731981,2
    		C,H--47277712(+) GATCTC/TGGCTC 3 -- ds50010--------
    rs1506906461,2
    		--47277766(+) AGCCTC/TCTGAG 3 -- ds50010--------
    rs116659261,2
    		C,A,H--47277816(+) TTTTTG/ATATTT 3 -- ds50013Minor allele frequency- A:0.00NA WA CSA 5
    rs621348381,2
    		--47277891(+) CCCGCT/CTCGGC 3 -- ds50011Minor allele frequency- C:0.00NA 2
    rs1895240891,2
    		--47277969(+) GAGACA/GATGTC 3 -- ds50010--------
    rs1807664081,2
    		--47278069(+) CAGTGC/GTGTTT 3 -- ds50010--------
    rs1850162411,2
    		--47278070(+) AGTGGC/TGTTTC 3 -- ds50010--------
    rs1171581281,2
    		C,F--47278198(+) AGCAGG/ATATTT 3 -- ut311Minor allele frequency- A:0.02EA 120
    rs1438578411,2
    		--47278283(+) TGGGAC/TGTACC 3 -- ut310--------
    rs1902648921,2
    		--47278284(+) GGGACA/GTACCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC1A5 (47278140 - 47291842 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC1A5
         1 CNV: 5104

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    Disorders / Diseases
    for SLC1A5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC1A5 for disorders           About GeneDecksing

    OMIM gene information: 109190    OMIM disorders: --

    15 diseases for SLC1A5:    About MalaCards
    pre-eclampsia    placental choriocarcinoma    hartnup disease    pellagra
    cystinuria    phenylketonuria    cystic fibrosis    eclampsia
    choriocarcinoma    fibrosis    hypoxia    schizophrenia
    tuberculosis    neuronitis    mycobacterium tuberculosis

    4 diseases from the University of Copenhagen DISEASES database for SLC1A5:
    Hartnup disease     Pellagra     Cystinuria     Phenylketonuria

    1 Novoseek disease relationship for SLC1A5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 1 12664292 (1)

    Genetic Association Database (GAD): SLC1A5
    Human Genome Epidemiology (HuGE) Navigator: SLC1A5 (1 document)

    Export disorders for SLC1A5 gene to outside databases

    Publications
    for SLC1A5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC1A5 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with SLC1A5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. (PubMed id 10051606)1, 2, 3, 9 Rasko J.E.J.... Miller A.D. (1999)
    2. Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. (PubMed id 8702519)1, 2, 3, 9 Kekuda R.... Ganapathy V. (1996)
    3. Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. (PubMed id 11350958)1, 2, 9 Tailor C.S.... Kabat D. (2001)
    4. High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. (PubMed id 16516348)1, 7 Gegelashvili M....Gegelashvili G. (2006)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. (PubMed id 16197915)1, 7 Bungard C.I. and McGivan J.D. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. ATB(0)/SLC1A5 gene. Fine localisation and exclusion of association with the intestinal phenotype of cystic fibrosis. (PubMed id 11781704)1, 4 Larriba S....Nunes V. (2001)

    External Searches for SLC1A5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing SLC1A5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6510 HGNC: 10943 AceView: SLC1A5 Ensembl:ENSG00000105281 euGenes: HUgn6510
    ECgene: SLC1A5 Kegg: 6510 H-InvDB: SLC1A5

    Other Databases showing SLC1A5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC1A5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC1A5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC1A5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SLC1A5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC1A5 gene:
    Search GeneIP for patents involving SLC1A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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