Aliases for SLC1A5 Gene
External Ids for SLC1A5 Gene
Previous HGNC Symbols for SLC1A5 Gene
Previous GeneCards Identifiers for SLC1A5 Gene
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]
GeneCards Summary for SLC1A5 Gene
SLC1A5 (Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5) is a Protein Coding gene. Diseases associated with SLC1A5 include lacrimal gland adenocarcinoma and lacrimal gland adenoid cystic carcinoma. Among its related pathways are Central carbon metabolism in cancer and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC1A3.
UniProtKB/Swiss-Prot for SLC1A5 Gene
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).