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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC1A4 Gene

protein-coding   GIFtS: 59
GCID: GC02P065216

solute carrier family 1 (glutamate/neutral amino acid transporter),...
 Explore 24 diseases affiliated with
SLC1A4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC1A4    

Aliases
for SLC1A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member
41 2
     Solute Carrier Family 1 Member 42 3
ASCT11 2 3 5     ASCT-12 3
SATT1 2 3 5     Glutamate/Neutral Amino Acid Transporter2
Alanine/Serine/Cysteine/Threonine Transporter 12 3     Neutral Amino Acid Transporter A2

External Ids:    HGNC: 109421   Entrez Gene: 65092   Ensembl: ENSG000001159027   OMIM: 6002295   UniProtKB: P430073   

Export aliases for SLC1A4 gene to outside databases

Previous GC identifers: GC02P065350 GC02P065173 GC02P065191 GC02P065128 GC02P065070 GC02P064949


Summaries
for SLC1A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SATT_HUMAN, P43007
Function: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

Gene Wiki entry for SLC1A4


Genomic Views
for SLC1A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC1A4 gene promoter:
         C/EBPbeta   STAT5A   AP-2gamma   YY1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC1A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC1A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC1A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15-p13   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p15-p13

SLC1A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC1A4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P065216:  view genomic region     (about GC identifiers)

Start:
 65,215,579 bp from pter      End:
 65,250,999 bp from pter
Size:
 35,421 bases      Orientation:
 plus strand

Proteins
for SLC1A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SATT_HUMAN, P43007 (See protein sequence)
Recommended Name: Neutral amino acid transporter A  
Size: 532 amino acids; 55723 Da
Subcellular location: Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in
melanosome fractions from stage I to stage IV
Secondary accessions: B7Z3C0 D6W5F0
Alternative splicing: 2 isoforms:  P43007-1   P43007-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC1A4: NX_P43007

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43007

    • SLC1A4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180422.1  NP_003029.2  

    ENSEMBL proteins: 
     ENSP00000431942   ENSP00000234256  
    Reactome Protein details: P43007
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC1A4 Protein
    Novus Biologicals SLC1A4 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC1A4

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IC8910405
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS8101838


    SLC1A4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC1A4

    Protein Domains /
    Families
    for SLC1A4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC1A4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001991 Na-dicarboxylate_symporter
     IPR018107 Na-dicarboxylate_symporter_CS

    Graphical View of Domain Structure for InterPro Entry P43007

    ProtoNet protein and cluster: P43007

    1 Blocks protein family: IPB001991 Sodium:dicarboxylate symporter

    UniProtKB/Swiss-Prot: SATT_HUMAN, P43007
    Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily


    Function
    for SLC1A4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SATT_HUMAN, P43007
    Function: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

         Genatlas biochemistry entry for SLC1A4:
    solute carrier family 1,member A4,glutamate/neutral amino acid transporter

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC1A4
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC1A4 (see all 31):
    hsa-miR-579 hsa-miR-3910 hsa-miR-642a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmid: SLC1A4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IDA8910405
    GO:0015175neutral amino acid transmembrane transporter activity ----
    GO:0015180L-alanine transmembrane transporter activity IDA8340364
    GO:0015184NOT L-cystine transmembrane transporter activity IDA8340364
    GO:0015186L-glutamine transmembrane transporter activity TAS--


    SLC1A4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SLC1A4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    		Amino acid transport across the plasma membrane0.63
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Neuroscience
    		Neuroscience1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SLC1A4
        Neuroscience

    5        Reactome Pathways for SLC1A4
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Amino acid transport across the plasma membrane
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC1A4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC1A4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC1A4 (P430073 ENSP000002342564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERVW-1Q9UQF03, ENSP000004199454I2D: score=1 STRING: ENSP00000419945
    UBCENSP000003448184STRING: ENSP00000344818
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006821chloride transport IDA8910405
    GO:0006865amino acid transport TAS--
    GO:0006868glutamine transport TAS--
    GO:0015804neutral amino acid transport ----


    SLC1A4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC1A4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC1A4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC1A4

    6 HMDB Compounds for SLC1A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydroxyproline(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid (see all 21)51-35-4--
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Cystine(-)-Cystine (see all 31)56-89-3--
    L-Serine(-)-Serine (see all 26)56-45-1--
    L-Threonine(2S,3R)-(-)-Threonine (see all 21)72-19-5--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC1A4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Alanine(2S)-2-Aminopropanoic acid (see all 15)56-41-7target--17510490 17195090 17475673 17311416 17237199

    10 Novoseek chemical compound relationships for SLC1A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 57.2 21 10964674 (2), 17106422 (1), 7702599 (1), 9266331 (1) (see all 14)
    glutamine 54.6 6 11746424 (1), 11331400 (1), 17311416 (1)
    alanine 50.4 6 11824937 (2), 17311416 (2), 10811809 (1)
    serine 46.5 5 15099708 (2), 12846552 (1), 10357852 (1)
    phenylalanine 43 2 2109147 (1), 16046863 (1)
    leucine 25.3 1 2109147 (1)
    gaba 20.5 2 12477895 (1)
    threonine 15.2 1 11746424 (1)
    histidine 4.88 1 2109147 (1)
    tyrosine 0 1 2109147 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC1A4 / SATT 

    Transcripts
    for SLC1A4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC1A4 gene (3 alternative transcripts): 
    NM_001135581.1  NM_001193493.1  NM_003038.4  

    Unigene Cluster for SLC1A4:

    Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
    Hs.654352  [show with all ESTs]
    Unigene Representative Sequence: AK126636
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493121 ENST00000471551 ENST00000531327 ENST00000234256(uc010ypz.2 uc010yqa.2)
    ENST00000480594(uc002sdh.3)

    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC1A4 (see all 31):
    hsa-miR-579 hsa-miR-3910 hsa-miR-642a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmid: SLC1A4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB026689.1 AK126636.1 AK223486.1 AK295687.1 AK298472.1 AK313052.1 AK315986.1 AL833067.1 
    BC007350.2 BC026216.1 BC072423.1 L14595.1 L19444.1 

    6 DOTS entries:

    DT.95138598  DT.65285317  DT.99945225  DT.432311  DT.100816432  DT.95307098 

    24/295 AceView cDNA sequences (see all 295):

    BM928417 AA668980 BQ057975 CK902455 BQ061696 BQ054939 CB159799 AW196056 
    BX111113 AK126636 BG679436 BM564840 AW204539 BQ643322 Z43187 BC072423 
    AI889380 BQ642598 CR625932 BQ066795 CR621750 BP379274 N41953 BQ057830 

    GeneLoc Exon Structure


    Expression
    for SLC1A4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC1A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGACAATTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC1A4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    LiverLiver LobulePerivenous HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)

    See SLC1A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC1A4

    SOURCE GeneReport for Unigene cluster: Hs.654352

    UniProtKB/Swiss-Prot: SATT_HUMAN, P43007
    Tissue specificity: Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined

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    In Situ
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    Orthologs
    for SLC1A4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC1A4 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC1A41 solute carrier family 1 (glutamate/neutral amino acid more 76.42(n)
    80.96(a)    		   769612  XM_001232899.2  XP_001232900.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC1A46
    		 --
    		 76(a)
    		 1 ↔ 1
    		 1(124379708-124418441)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc1a41 solute carrier family 1 (glutamate/neutral amino acid more 70.09(n)
    75.56(a)    		   368885  NM_001002513.2  NP_001002513.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eaat13 sodium/excitatory glutamate cotransporter 37(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea T22E5.23 sodium-dependent glutamate/aspartate
    transporter    		 39(a)
    (best of 2)    		   X(6437359-6441747)   --
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria gltP6
    dctA6
    (see all 3)    		 glutamate/aspartate:proton symporter
    C4-dicarboxylic acid, orotate and citrate transpor...
    (see all 3)    		 24(a)
    23(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 Chromosome(4292504-4293817)
    Chromosome(3680184-3681470)


    ENSEMBL Gene Tree for SLC1A4 (if available)
    TreeFam Gene Tree for SLC1A4 (if available) 

    Paralogs
    for SLC1A4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC1A4 gene
    SLC1A32  SLC1A52  SLC1A72  SLC1A12  SLC1A22  SLC1A62  
    6 SIMAP similar genes for SLC1A4 using alignment to 1 protein entry:     SATT_HUMAN:
    SLC1A5    SLC1A3    SLC1A6    SLC1A1    SLC1A2    SLC1A7

    SLC1A4 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC1A4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/698 NCBI SNPs in SLC1A4 are shown (see all 698)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1177246361,2
    		F,--65213583(+) TCCCAA/GTTGAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs675859831,2
    		C,F,--65213584(+) CCCAAT/CTGAGG 1 -- us2k15Minor allele frequency- C:0.19WA NA EA 362
    rs101941071,2
    		C,--65213822(+) GTAGGC/TCTCGA 1 -- us2k111Minor allele frequency- T:0.13WA NA CSA EA 372
    rs1841155051,2
    		--65213829(+) TCGAAA/TGCCAG 1 -- us2k10--------
    rs751440571,2
    		F,--65213830(+) CGAATG/CCCAGG 1 -- us2k11Minor allele frequency- C:0.15WA 118
    rs1410631371,2
    		--65213887(+) AACAAA/GAAGTG 1 -- us2k10--------
    rs1446617171,2
    		--65213973(+) GGATGC/TCTGTG 1 -- us2k10--------
    rs739348971,2
    		C,F,--65214027(+) TGGTCA/GTTTGA 1 -- us2k13Minor allele frequency- G:0.12WA CSA 122
    rs1869327451,2
    		--65214073(+) GTGTAC/TGACTT 1 -- us2k10--------
    rs1914725441,2
    		--65214653(+) GGGCTA/GATTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC1A4 (65215579 - 65250999 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC1A4: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SLC1A4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC1A4 for disorders           About GeneDecksing

    OMIM gene information: 600229    OMIM disorders: --

    20/24 diseases for SLC1A4 (see all 24):    About MalaCards
    hartnup disease    episodic ataxia    multiple system atrophy    aminoaciduria
    cystinuria    transitional cell carcinoma    hemiplegia    mood disorder
    bipolar disorder    papillary carcinoma    multiple sclerosis    esophageal carcinoma
    ataxia    seizures    esophagitis    schizophrenia
    carcinoma    breast cancer    hypertension    cerebritis

    3 Novoseek disease relationships for SLC1A4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 8.31 9 18638388 (4), 17106422 (1), 9034006 (1), 10994645 (1)
    cancer 4.42 1 15916903 (1)
    tumors 0 1 15916903 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC1A4 (5 documents)

    Export disorders for SLC1A4 gene to outside databases

    Publications
    for SLC1A4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC1A4 gene, integrated from 9 sources (see all 110):
    (articles sorted by number of sources associating them with SLC1A4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15. (PubMed id 7896285)1, 2, 3, 9 Hofmann K.... Stoffel W. (1994)
    2. ASCT-1 is a neutral amino acid exchanger with chlorid e channel activity. (PubMed id 8910405)1, 3, 9 Zerangue N. and Kavanaugh M.P. (1996)
    3. Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. (PubMed id 8101838)1, 2, 9 Arriza J.L.... Amara S.G. (1993)
    4. Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. (PubMed id 8340364)1, 2, 9 Shafqat S.... Fremeau R.T. Jr. (1993)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sample. (PubMed id 17106422)1, 9 Skowronek M.H....Rietschel M. (2006)
    9. N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. (PubMed id 12584318)1, 9 Marin M....Kabat D. (2003)
    10. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. (PubMed id 18638388)1, 9 Deng X....Fukumaki Y. (2008)

    External Searches for SLC1A4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLC1A4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6509 HGNC: 10942 AceView: SLC1A4 Ensembl:ENSG00000115902 euGenes: HUgn6509
    ECgene: SLC1A4 H-InvDB: SLC1A4

    Other Databases showing SLC1A4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC1A4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC1A4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC1A4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC1A4 gene:
    Search GeneIP for patents involving SLC1A4

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