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Aliases for SLC1A3 Gene

Aliases for SLC1A3 Gene

  • Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 3 2 3
  • EAAT1 3 4 6
  • Sodium-Dependent Glutamate/Aspartate Transporter 1 3 4
  • Solute Carrier Family 1 Member 3 3 4
  • GLAST-1 3 4
  • GLAST1 3 4
  • GLAST 3 4
  • EA6 3 6
  • Glutamate Transporter Variant EAAT1ex9skip 2
  • Excitatory Amino Acid Transporter 1 3

External Ids for SLC1A3 Gene

Summaries for SLC1A3 Gene

Entrez Gene Summary for SLC1A3 Gene

  • This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]

GeneCards Summary for SLC1A3 Gene

SLC1A3 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 3) is a Protein Coding gene. Diseases associated with SLC1A3 include episodic ataxia, type 6 and brain injury. Among its related pathways are SIDS Susceptibility Pathways and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include L-glutamate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC1A6.

UniProtKB/Swiss-Prot for SLC1A3 Gene

  • Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

Tocris Summary for SLC1A3 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.

Gene Wiki entry for SLC1A3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A3 Gene

Genomics for SLC1A3 Gene

Genomic Location for SLC1A3 Gene

Start:
36,606,355 bp from pter
End:
36,688,334 bp from pter
Size:
81,980 bases
Orientation:
Plus strand

Genomic View for SLC1A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A3 Gene

Regulatory Elements for SLC1A3 Gene

Proteins for SLC1A3 Gene

  • Protein details for SLC1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43003-EAA1_HUMAN
    Recommended name:
    Excitatory amino acid transporter 1
    Protein Accession:
    P43003
    Secondary Accessions:
    • B2R5T3
    • Q4JCQ8

    Protein attributes for SLC1A3 Gene

    Size:
    542 amino acids
    Molecular mass:
    59572 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC1A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A3 Gene

Proteomics data for SLC1A3 Gene at MOPED

Post-translational modifications for SLC1A3 Gene

No data available for DME Specific Peptides for SLC1A3 Gene

Domains for SLC1A3 Gene

Gene Families for SLC1A3 Gene

Protein Domains for SLC1A3 Gene

Graphical View of Domain Structure for InterPro Entry

P43003

UniProtKB/Swiss-Prot:

EAA1_HUMAN
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily.:
    • P43003
genes like me logo Genes that share domains with SLC1A3: view

Function for SLC1A3 Gene

Molecular function for SLC1A3 Gene

GENATLAS Biochemistry: solute carrier family 1,member A3,glial high affinity glutamate/aspartate transporter in the cerebellum,located in astrocytes,involved in development and neonatal hypoxic-ischemic damage
UniProtKB/Swiss-Prot Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

Gene Ontology (GO) - Molecular Function for SLC1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity IDA 7521911
GO:0005314 high-affinity glutamate transmembrane transporter activity IEA --
GO:0005515 protein binding --
GO:0016595 glutamate binding IEA --
GO:0016597 amino acid binding --
genes like me logo Genes that share ontologies with SLC1A3: view
genes like me logo Genes that share phenotypes with SLC1A3: view

Animal Models for SLC1A3 Gene

MGI Knock Outs for SLC1A3:

miRNA for SLC1A3 Gene

miRTarBase miRNAs that target SLC1A3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC1A3 Gene

Localization for SLC1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A3 Gene COMPARTMENTS Subcellular localization image for SLC1A3 gene
Compartment Confidence
plasma membrane 4
extracellular 3
mitochondrion 3
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for SLC1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 7521911
GO:0016021 integral component of membrane IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SLC1A3: view

Pathways for SLC1A3 Gene

genes like me logo Genes that share pathways with SLC1A3: view

Pathways by source for SLC1A3 Gene

1 R&D Systems pathway for SLC1A3 Gene
1 Qiagen pathway for SLC1A3 Gene
1 Cell Signaling Technology pathway for SLC1A3 Gene

Interacting Proteins for SLC1A3 Gene

Gene Ontology (GO) - Biological Process for SLC1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001504 neurotransmitter uptake TAS 8647279
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006536 glutamate metabolic process --
GO:0006537 glutamate biosynthetic process IEA --
GO:0006811 ion transport TAS --
genes like me logo Genes that share ontologies with SLC1A3: view

Compounds for SLC1A3 Gene

(5) Tocris Compounds for SLC1A3 Gene

Compound Action Cas Number
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake [52497-36-6]
DL-TBOA Selective non-transportable inhibitor of EAATs [205309-81-5]
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor [64769-66-0]
TFB-TBOA High affinity EAAT1 and EAAT2 blocker [480439-73-4]
WAY 213613 Potent, non-substrate EAAT2 inhibitor [868359-05-1]

(1) HMDB Compounds for SLC1A3 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC1A3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(6) IUPHAR Ligand for SLC1A3 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]ETB-TBOA None None 7.8
UCPH-101 Inhibitor Inhibition 6.9
DL-TBOA Inhibitor Inhibition 6.9
[3H]L-aspartic acid None None
[3H]D-aspartic acid None None
[3H](2S,4R)-4-methylglutamate None None

(28) Novoseek inferred chemical compound relationships for SLC1A3 Gene

Compound -log(P) Hits PubMed IDs
glutamate 87.9 193
dihydrokainate 83.5 1
dl-threo-beta-benzyloxyaspartate 81.5 2
l-trans-pyrrolidine-2,4-dicarboxylic acid 79.5 3
aspartate 69 28
genes like me logo Genes that share compounds with SLC1A3: view

Transcripts for SLC1A3 Gene

Unigene Clusters for SLC1A3 Gene

Solute carrier family 1 (glial high affinity glutamate transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6:
SP7:
SP8: -

Relevant External Links for SLC1A3 Gene

GeneLoc Exon Structure for
SLC1A3
ECgene alternative splicing isoforms for
SLC1A3

Expression for SLC1A3 Gene

mRNA expression in normal human tissues for SLC1A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC1A3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.8), Brain - Amygdala (5.6), Brain - Caudate (basal ganglia) (5.2), Brain - Putamen (basal ganglia) (4.8), and Brain - Frontal Cortex (BA9) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC1A3 Gene

SOURCE GeneReport for Unigene cluster for SLC1A3 Gene Hs.481918

mRNA Expression by UniProt/SwissProt for SLC1A3 Gene

P43003-EAA1_HUMAN
Tissue specificity: Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia
genes like me logo Genes that share expressions with SLC1A3: view

Orthologs for SLC1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A3 35
  • 99.69 (n)
  • 99.82 (a)
SLC1A3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A3 35
  • 91.27 (n)
  • 97.79 (a)
SLC1A3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLAST 36
  • 97 (a)
OneToOne
SLC1A3 35
  • 91.27 (n)
  • 97.05 (a)
mouse
(Mus musculus)
Mammalia Slc1a3 35
  • 89.18 (n)
  • 96.68 (a)
Slc1a3 16
Slc1a3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC1A3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a3 35
  • 88.56 (n)
  • 97.05 (a)
chicken
(Gallus gallus)
Aves SLC1A3 35
  • 79.52 (n)
  • 89.11 (a)
SLC1A3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A3 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68789 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a3 35
  • 77.43 (n)
  • 86.72 (a)
Str.15311 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28289 35
slc1a3a 35
  • 71.34 (n)
  • 77.01 (a)
slc1a3a 36
  • 77 (a)
OneToMany
slc1a3b 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 37
  • 46 (a)
Eaat2 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-5 35
  • 56.33 (n)
  • 52.53 (a)
glt-2 37
  • 53 (a)
K08F4.4 37
  • 45 (a)
T22E5.2 37
  • 47 (a)
R05G6.6 37
  • 38 (a)
W03G1.1 37
  • 36 (a)
Y53C12A.2 37
  • 48 (a)
Species with no ortholog for SLC1A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A3 Gene

ENSEMBL:
Gene Tree for SLC1A3 (if available)
TreeFam:
Gene Tree for SLC1A3 (if available)

Paralogs for SLC1A3 Gene

Paralogs for SLC1A3 Gene

Selected SIMAP similar genes for SLC1A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC1A3: view

Variants for SLC1A3 Gene

Sequence variations from dbSNP and Humsavar for SLC1A3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs366597 -- 36,635,842(+) TCATT(A/G)TGAAG intron-variant
rs369708 -- 36,643,820(+) aaacc(A/G)agtct intron-variant
rs371511 -- 36,636,505(-) AGAAA(A/G)AGAAA intron-variant
rs372171 -- 36,636,853(+) CCTTG(C/T)TACCA intron-variant
rs378427 -- 36,634,565(+) AACAT(A/T)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A3 Gene

Variant ID Type Subtype PubMed ID
nsv881025 CNV Gain 21882294
nsv830263 CNV Gain 17160897
nsv526573 CNV Loss 19592680
nsv880571 CNV Loss 21882294

Relevant External Links for SLC1A3 Gene

HapMap Linkage Disequilibrium report
SLC1A3
Human Gene Mutation Database (HGMD)
SLC1A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A3 Gene

Disorders for SLC1A3 Gene

(1) OMIM Diseases for SLC1A3 Gene (600111)

UniProtKB/Swiss-Prot

EAA1_HUMAN
  • Episodic ataxia 6 (EA6) [MIM:612656]: A disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia. {ECO:0000269 PubMed:16116111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for SLC1A3 Gene

(22) Novoseek inferred disease relationships for SLC1A3 Gene

Disease -log(P) Hits PubMed IDs
amyotrophic lateral sclerosis 61.8 4
neurodegeneration 54.9 1
gliosis 46.8 1
epilepsy temporal lobe 35.2 1
brain diseases 31.7 2

Relevant External Links for SLC1A3

Genetic Association Database (GAD)
SLC1A3
Human Genome Epidemiology (HuGE) Navigator
SLC1A3
genes like me logo Genes that share disorders with SLC1A3: view

Publications for SLC1A3 Gene

  1. Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12. (PMID: 8647279) Stoffel W. … Lichter P. (FEBS Lett. 1996) 3 4 23
  2. Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures. (PMID: 16116111) Jen J.C. … Baloh R.W. (Neurology 2005) 3 4 23
  3. A novel alternative splicing form of excitatory amino acid transporter 1 is a negative regulator of glutamate uptake. (PMID: 16042756) Vallejo-Illarramendi A. … Matute C. (J. Neurochem. 2005) 3 4 23
  4. Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia. (PMID: 17221839) Deng X. … Fukumaki Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  5. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. (PMID: 7521911) Arriza J.L. … Amara S.G. (J. Neurosci. 1994) 2 3 4

Products for SLC1A3 Gene

Sources for SLC1A3 Gene

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