Aliases for SLC1A3 Gene
External Ids for SLC1A3 Gene
Previous GeneCards Identifiers for SLC1A3 Gene
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]
GeneCards Summary for SLC1A3 Gene
SLC1A3 (Solute Carrier Family 1 Member 3) is a Protein Coding gene. Diseases associated with SLC1A3 include Episodic Ataxia, Type 6 and Episodic Ataxia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include amino acid binding and glutamate binding. An important paralog of this gene is SLC1A6.
UniProtKB/Swiss-Prot for SLC1A3 Gene
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.