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Aliases for SLC1A2 Gene

Aliases for SLC1A2 Gene

  • Solute Carrier Family 1 Member 2 2 3 4 5
  • Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 2 3
  • Sodium-Dependent Glutamate/Aspartate Transporter 2 3 4
  • Glutamate/Aspartate Transporter II 3 4
  • EAAT2 3 4
  • Excitotoxic Amino Acid Transporter 2 3
  • Excitatory Amino Acid Transporter 2 3
  • GLT-1 3
  • HBGT 3
  • GLT1 4

External Ids for SLC1A2 Gene

Previous GeneCards Identifiers for SLC1A2 Gene

  • GC11M036834
  • GC11M035960
  • GC11M035315
  • GC11M035246
  • GC11M035237
  • GC11M035229
  • GC11M034972

Summaries for SLC1A2 Gene

Entrez Gene Summary for SLC1A2 Gene

  • This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for SLC1A2 Gene

SLC1A2 (Solute Carrier Family 1 Member 2) is a Protein Coding gene. Diseases associated with SLC1A2 include Leukomalacia and Wernicke Encephalopathy. Among its related pathways are Neurotransmitter Release Cycle and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include L-glutamate transmembrane transporter activity and glutamate:sodium symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A2 Gene

  • Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Tocris Summary for SLC1A2 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.

Gene Wiki entry for SLC1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A2 Gene

Genomics for SLC1A2 Gene

Regulatory Elements for SLC1A2 Gene

Enhancers for SLC1A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC1A2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC1A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC1A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC1A2 Gene

Chromosome:
11
Start:
35,251,205 bp from pter
End:
35,420,063 bp from pter
Size:
168,859 bases
Orientation:
Minus strand

Genomic View for SLC1A2 Gene

Genes around SLC1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A2 Gene

Proteins for SLC1A2 Gene

  • Protein details for SLC1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43004-EAA2_HUMAN
    Recommended name:
    Excitatory amino acid transporter 2
    Protein Accession:
    P43004
    Secondary Accessions:
    • B4DQE9
    • Q14417
    • Q541G6
    • U3KQQ4

    Protein attributes for SLC1A2 Gene

    Size:
    574 amino acids
    Molecular mass:
    62104 Da
    Quaternary structure:
    • Homotrimer. Isoform 3 can oligomerize with isoform 1. Interacts with AJUBA (By similarity).

    Alternative splice isoforms for SLC1A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A2 Gene

Post-translational modifications for SLC1A2 Gene

  • Glycosylated.
  • Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.
  • Glycosylation at Asn 206 and Asn 216
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC1A2 (GLT1)

No data available for DME Specific Peptides for SLC1A2 Gene

Domains & Families for SLC1A2 Gene

Gene Families for SLC1A2 Gene

Protein Domains for SLC1A2 Gene

Graphical View of Domain Structure for InterPro Entry

P43004

UniProtKB/Swiss-Prot:

EAA2_HUMAN :
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily.
Family:
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily.
genes like me logo Genes that share domains with SLC1A2: view

Function for SLC1A2 Gene

Molecular function for SLC1A2 Gene

GENATLAS Biochemistry:
solute carrier family 1,member A2,glial high affinity glutamate transporter,expressed in brain and pancreas,located in astrocytes,with five transcripts alternatively spliced from 5utr and a variant acting as a putative modifier for the spastic paraplegia phenotype
UniProtKB/Swiss-Prot Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Gene Ontology (GO) - Molecular Function for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity IDA 7521911
GO:0005314 high-affinity glutamate transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 19527721
GO:0008509 anion transmembrane transporter activity IEA --
GO:0015171 amino acid transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC1A2: view
genes like me logo Genes that share phenotypes with SLC1A2: view

Animal Models for SLC1A2 Gene

MGI Knock Outs for SLC1A2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC1A2 Gene

Localization for SLC1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A2 Gene COMPARTMENTS Subcellular localization image for SLC1A2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 21399631
GO:0016020 membrane TAS 7521911
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with SLC1A2: view

Pathways & Interactions for SLC1A2 Gene

genes like me logo Genes that share pathways with SLC1A2: view

Pathways by source for SLC1A2 Gene

Gene Ontology (GO) - Biological Process for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006811 ion transport TAS --
GO:0007268 chemical synaptic transmission TAS 7521911
GO:0007399 nervous system development IEA --
GO:0007632 visual behavior IEA --
genes like me logo Genes that share ontologies with SLC1A2: view

No data available for SIGNOR curated interactions for SLC1A2 Gene

Drugs & Compounds for SLC1A2 Gene

(48) Drugs for SLC1A2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DL-TBOA Pharma Inhibition, Inhibitor inhibitor of excitatory amino acid transporters, Selective non-transportable inhibitor of EAATs 0
dihydrokainate Pharma Inhibition, Inhibitor 0
7-Chlorokynurenic acid sodium salt Pharma Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 0
Dihydrokainic acid Pharma EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake 0
L-trans-2,4-PDC Pharma Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 0

(20) Additional Compounds for SLC1A2 Gene - From: IUPHAR, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
[<sup>3</sup>H]ETB-TBOA

(5) Tocris Compounds for SLC1A2 Gene

Compound Action Cas Number
7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 1263094-00-3
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake 52497-36-6
DL-TBOA Selective non-transportable inhibitor of EAATs 205309-81-5
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 64769-66-0
TFB-TBOA High affinity EAAT1 and EAAT2 blocker 480439-73-4

(17) ApexBio Compounds for SLC1A2 Gene

Compound Action Cas Number
(±)-HIP-A 227619-64-9
(±)-HIP-B 227619-65-0
(±)-threo-3-Methylglutamic acid 63088-04-0
7-Chlorokynurenic acid 18000-24-3
7-Chlorokynurenic acid sodium salt 1263094-00-3
cis-ACBD 73550-55-7
Congo Red 573-58-0
Dihydrokainic acid 52497-36-6
DL-TBOA inhibitor of excitatory amino acid transporters 205309-81-5
L-(-)-threo-3-Hydroxyaspartic acid 7298-99-9
L-CCG-lll 117857-95-1
LDN 212320 894002-50-7
L-trans-2,4-PDC 64769-66-0
MPDC 159262-32-5
TFB-TBOA 480439-73-4
UCPH 101 1118460-77-7
WAY 213613 868359-05-1
genes like me logo Genes that share compounds with SLC1A2: view

Transcripts for SLC1A2 Gene

Unigene Clusters for SLC1A2 Gene

Solute carrier family 1 (glial high affinity glutamate transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -

Relevant External Links for SLC1A2 Gene

GeneLoc Exon Structure for
SLC1A2
ECgene alternative splicing isoforms for
SLC1A2

Expression for SLC1A2 Gene

mRNA expression in normal human tissues for SLC1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC1A2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x8.3), Brain - Nucleus accumbens (basal ganglia) (x7.7), Brain - Amygdala (x7.5), Brain - Putamen (basal ganglia) (x7.2), Brain - Frontal Cortex (BA9) (x4.9), Brain - Cortex (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for SLC1A2 Gene

This gene is overexpressed in Frontal cortex (33.3) and Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC1A2 Gene



Protein tissue co-expression partners for SLC1A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC1A2 Gene:

SLC1A2

SOURCE GeneReport for Unigene cluster for SLC1A2 Gene:

Hs.502338
genes like me logo Genes that share expression patterns with SLC1A2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC1A2 Gene

Orthologs for SLC1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC1A2 34
  • 90.71 (n)
  • 97.04 (a)
SLC1A2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A2 34
  • 91.37 (n)
  • 96.63 (a)
SLC1A2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a2 34
  • 88.64 (n)
  • 95.45 (a)
Slc1a2 16
Slc1a2 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC1A2 34
  • 99.59 (n)
  • 100 (a)
SLC1A2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a2 34
  • 88.77 (n)
  • 95.64 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC1A2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A2 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC1A2 34
  • 78.76 (n)
  • 88.77 (a)
SLC1A2 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A2 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a2 34
  • 75.91 (n)
  • 85.16 (a)
zebrafish
(Danio rerio)
Actinopterygii slc1a2b 34
  • 72.1 (n)
  • 79.93 (a)
wufj34b12 34
slc1a2a 35
  • 78 (a)
OneToMany
slc1a2b 35
  • 78 (a)
OneToMany
slc1a9 35
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 36
  • 43 (a)
Eaat2 36
  • 43 (a)
Eaat2 35
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea glt-2 36
  • 62 (a)
K08F4.4 36
  • 50 (a)
R05G6.6 36
  • 43 (a)
T22E5.2 36
  • 44 (a)
W03G1.1 36
  • 34 (a)
Y53C12A.2 36
  • 51 (a)
glt-1 34
  • 58.47 (n)
  • 61.46 (a)
glt-1 35
  • 58 (a)
OneToMany
glt-3 35
  • 46 (a)
OneToMany
glt-5 35
  • 50 (a)
OneToMany
glt-6 35
  • 43 (a)
OneToMany
glt-7 35
  • 36 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5947 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.317 35
  • 43 (a)
OneToOne
Species where no ortholog for SLC1A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A2 Gene

ENSEMBL:
Gene Tree for SLC1A2 (if available)
TreeFam:
Gene Tree for SLC1A2 (if available)

Paralogs for SLC1A2 Gene

Paralogs for SLC1A2 Gene

(6) SIMAP similar genes for SLC1A2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC1A2: view

Variants for SLC1A2 Gene

Sequence variations from dbSNP and Humsavar for SLC1A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001525 -- 35,413,115(-) GAAGT(A/T)ATTGA intron-variant
rs1042109 -- 35,306,172(+) CGCTG(A/T)TGTCT reference, missense
rs1042110 -- 35,306,171(-) GCTGT(A/T)GTCTC reference, synonymous-codon
rs1042113 -- 35,286,822(-) GCGGT(A/G)GCCGC reference, synonymous-codon
rs1042115 -- 35,280,892(-) TCAGC(C/T)TGCTG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC1A2 Gene

Variant ID Type Subtype PubMed ID
esv2602066 CNV insertion 19546169
esv2759819 CNV gain 17122850
esv3304729 CNV mobile element insertion 20981092
esv3346457 CNV insertion 20981092
esv3625930 CNV loss 21293372
esv3625932 CNV loss 21293372
nsv1042014 CNV loss 25217958
nsv7733 CNV insertion 18451855
nsv832120 CNV gain 17160897
nsv975902 CNV duplication 23825009

Variation tolerance for SLC1A2 Gene

Residual Variation Intolerance Score: 9.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC1A2 Gene

Human Gene Mutation Database (HGMD)
SLC1A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A2 Gene

Disorders for SLC1A2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for SLC1A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukomalacia
wernicke encephalopathy
  • wernicke-korsakoff syndrome
periventricular leukomalacia
  • pvl
hepatic encephalopathy
  • portal-systemic encephalopathy
temporal lobe epilepsy
  • epilepsy, temporal lobe
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC1A2

Genetic Association Database (GAD)
SLC1A2
Human Genome Epidemiology (HuGE) Navigator
SLC1A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC1A2
genes like me logo Genes that share disorders with SLC1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC1A2 Gene

Publications for SLC1A2 Gene

  1. No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia. (PMID: 19660525) Nagai Y. … Arai H. (Neurosci. Lett. 2009) 3 22 46 65
  2. Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. (PMID: 15296513) Deng X. … Fukumaki Y. (BMC Psychiatry 2004) 3 22 46 65
  3. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. (PMID: 9463476) Shimamoto K. … Nakajima T. (Mol. Pharmacol. 1998) 3 4 22 65
  4. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. (PMID: 7521911) Arriza J.L. … Amara S.G. (J. Neurosci. 1994) 3 4 22 65
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65

Products for SLC1A2 Gene

Sources for SLC1A2 Gene

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