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SLC1A2 Gene

protein-coding GIFtS: 71

GC11M035229

solute carrier family 1 (glial high affinity glutamate transporter), member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EAAT2 ^¹, ², ³, ⁵
GLT-1 ^¹, ²
GLT1 ^³

Descriptions
Glutamate/aspartate transporter II ^², ³
Sodium-dependent glutamate/aspartate transporter 2 ^², ³
Solute carrier family 1 member 2 ^³
excitatory amino acid transporter 2 ^²
excitotoxic amino acid transporter 2 ^²
glial high affinity glutamate transporter ^²
solute carrier family 1 (glial high affinity glutamate transporter), member 2 ^²
solute carrier family 1, member 2 ^²

External Ids
HGNC: 10940¹
Entrez Gene: 6506²
UniProtKB: P43004³
Ensembl: ENSG00000110436⁷

Search outside databases for aliases for SLC1A2 gene

Previous GC identifers: GC11M036834 GC11M035960 GC11M035315 GC11M035246 GC11M035237

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC1A2:

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein

is the principal transporter that clears the excitatory neurotransmitter glutamate from the

extracellular space at synapses in the central nervous system. Glutamate clearance is necessary

for proper synaptic activation and to prevent neuronal damage from excessive activation of

glutamate receptors. Mutations in and decreased expression of this protein are associated with

amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been

described, but their full-length nature is not known. [provided by RefSeq]

UniProtKB/Swiss-Prot: EAA2_HUMAN, P43004

Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the

postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft.

Acts as a symport by cotransporting sodium

Gene Wiki entry for SLC1A2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SLC1A2 gene

Entrez Gene cytogenetic band: 11p13-p12 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13-p12

SLC1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M035229: (about GC identifiers)

Start:	35,229,328 bp from pter
End:	35,398,186 bp from pter
Size:	168,859 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EAA2_HUMAN, P43004 (See protein sequence)

Recommended Name: Excitatory amino acid transporter 2

Size: 574 amino acids; 62104 Da

Subunit: Homotrimer. Interacts with JUB (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q14417 Q541G6

Alternative splicing: 2 isoforms: P43004-1 P43004-2

Post-translational modifications:

Glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004162.2

ENSEMBL proteins:

ENSP00000379099 ENSP00000379102 ENSP00000278379

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EAAT2)
	Human Recombinant Proteins from Abnova (SLC1A2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	7521911
GO:0016021	integral to membrane	IEA	--
GO:0042734	presynaptic membrane	IEA	--
GO:0043197	dendritic spine	IEA	--
GO:0043198	dendritic shaft	IEA	--

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Antibodies for SLC1A2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SLC1A2
	Sigma-Aldrich Antibodies for SLC1A2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SLC1A2 (EAAT2)
	Antibodies from Abcam (EAAT2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SLC1A2)
	Novus Biologicals Antibodies for SLC1A2

Assays for SLC1A2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P43004

ProtoNet protein and cluster: P43004

1 Blocks protein family: IPB001991 Sodium:dicarboxylate symporter

UniProtKB/Swiss-Prot: EAA2_HUMAN, P43004

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC1A2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC1A2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004171

Applied Biosystems Silencer® siRNAs for SLC1A2

Sigma-Aldrich siRNA and siRNA Panels for SLC1A2

Sigma-Aldrich shRNA for SLC1A2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004171
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004171
untagged cDNA clones in CMV expression vector (see all 3): AK090810

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004171

UniProtKB/Swiss-Prot: EAA2_HUMAN, P43004

Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the

postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft.

Acts as a symport by cotransporting sodium

Genatlas biochemistry entry for SLC1A2:

solute carrier family 1,member A2,glial high affinity glutamate transporter,expressed in brain and

pancreas,located in astrocytes,with five transcripts alternatively spliced from 5'utr and a

variant acting as a putative modifier for the spastic paraplegia phenotype

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc1a2):

behavior/neurological

growth/size

homeostasis/metabolism

life span-post-weaning/aging

nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015293	symporter activity	IEA	--
GO:0015501	glutamate:sodium symporter activity	IEA	--
GO:0017153	sodium:dicarboxylate symporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for SLC1A2 (Your Favorite Gene powered by Ingenuity)

Glutamate Receptor Signaling
Amyotrophic Lateral Sclerosis Signaling

GeneDecks SLC1A2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SLC1A2

5/24 Interacting proteins for SLC1A2 (P43004² ENSP00000278379³) via UniProtKB, MINT, and/or STRING (see all 24 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPT	P10636²	MINT-7148372 MINT-7148349 MINT-7148361 MINT-7148384
SOD1	ENSP00000270142³	STRING (score=.969)
JUB	ENSP00000262713³	STRING (score=.955)
AQP4	ENSP00000372654³	STRING (score=.905)
ELANE	ENSP00000263621³	STRING (score=.875)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0006835	dicarboxylic acid transport	IEA	--
GO:0007268	synaptic transmission	TAS	7521911
GO:0007399	nervous system development	IEA	--
GO:0009416	response to light stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for SLC1A2

Sigma-Aldrich Small Molecules for SLC1A2:

Antagonist Inhibitor

Compounds for SLC1A2 available from Tocris Bioscience

Compound	Action	CAS number
WAY 213613	Potent, non-substrate EAAT2 inhibitor	[868359-05-1]
SYM 2081	Highly selective kainate agonist	[31137-74-3]
Dihydrokainic acid	EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake	[52497-36-6]
TFB-TBOA	High affinity EAAT1 and EAAT2 blocker	[480439-73-4]

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10/21 Novoseek chemical compound relationships for SLC1A2 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dihydrokainate	90.66	32	16137792 (2), 10548497 (2), 7521911 (2), 18674619 (1) (see all 15)
l-serine o-sulfate	73.59	1	9614067 (1)
dl-threo-beta-benzyloxyaspartate	61.56	2	9463476 (2)
pacap 38	45.04	2	17346813 (1), 17401678 (1)
cystine	38.61	3	12372536 (1), 11698255 (1)
ecdysone	27.06	2	10548497 (1), 10602327 (1)
chloride	19.37	3	12372536 (1), 9605566 (1), 9614067 (1)
dbc-amp	13.29	9	9495799 (4), 15605988 (1)
oxygen	0.00	4	11905039 (1), 19061913 (1), 12742081 (1)
sodium	0.00	3	12372536 (1), 9605566 (1), 10762090 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC1A2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC1A2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004171

Sigma-Aldrich siRNA and siRNA Panels for SLC1A2

Sigma-Aldrich shRNA for SLC1A2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004171

REFSEQ mRNAs for SLC1A2 gene:

NM_004171.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004171

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004171
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004171
                                 untagged cDNA clones in CMV expression vector (see all 3): AK090810

Additional cDNA sequence:

AB209444.1 AF131756.1 AK054855.1 AK057674.1 AK090810.1 AK122843.1 AK298769.1 AL157452.1

AY066021.1 BC031313.2 BC047052.1 BC132768.1 BX538155.1 BX648750.1 CR626999.1 CR627009.1

CR627022.1 CR749842.1 D85884.1 S83375.1 U01824.1 U03505.1 Z32517.1

9 DOTS entries:

DT.316334 DT.207546 DT.95165959 DT.91669681 DT.91892540 DT.120720581 DT.91692744 DT.92431485

DT.95165960

24/214 AceView cDNA sequences (see all 214 ):

R15441 AL708179 AA683391 BM738748 F01536 T33174 F12361 F03925

AL706922 CB157661 AW005111 AI654538 AW590913 AI421461 CB156572 AI637987

CD673491 BI824607 AI207884 AA904135 D85884 N54714 T33751 AL119616

highest scoring ESTs for SLC1A2:

U01824 AW005111 AK122843 AU124528 AY066021 D85884 U03505 Z32517 AA020738 AA349588

Unigene Cluster for SLC1A2:

Solute carrier family 1 (glial high affinity glutamate transporter), member 2

Hs.502338 [show with all ESTs]

Unigene Representative Sequence: NM_004171

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A2

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14
SP1:									-				-
SP2:							-		-		-
SP3:											-		-
SP4:							-		-		-		-

About this scheme

ECgene alternative splicing isoforms for SLC1A2

3 Ensembl transcripts including schematic representations:

ENST00000395750 ENST00000395753 ENST00000278379

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SLC1A2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SLC1A2

¹ / ² / ³

12 probe-sets matching SLC1A2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90238_at²^{, 3}	U95-E	1	1.00	1.00	0.93	1.00	AI798939	0.60	1.00	0.82	1
45647_s_at²^{, 3}	U95-B	1	1.00	1.00	0.96	1.47	AW005111	0.80	1.00	0.91	1
34582_at²^{, 3}	U95-A	1	1.00	1.00	0.45	0.24	U01824	1.00	0.90	0.95	1
31323_r_at²^{, 3}	U95-A	1	0.38	1.00	0.51	0.65	S83374	0.60	0.83	0.73	1
208389_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004171	0.60	1.00	0.82	1
225491_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL157452	0.40	1.00	0.76	1
217055_x_at²^{, 3}	U133-A	1	0.27	1.00	--	--	S83374	0.60	0.83	0.73	1
208389_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558010_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558009_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225491_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217055_x_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

GeneDecks SLC1A2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AAGCACATTA

SOURCE GeneReport for Unigene cluster: Hs.502338
Expression variation in blood from EXPOLDB for SLC1A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for SLC1A2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC1A2¹	--	solute carrier family 1 (glial high affinity glutamate more	91.37(n) 96.63(a)	403750 NM_001003138.1 NP_001003138.1
chimpanzee (Pan troglodytes)	SLC1A2¹	--	solute carrier family 1 (glial high affinity glutamate more	99.47(n) 99.65(a)	450180 XM_508369.2 XP_508369.2
cow (Bos taurus)	SLC1A2¹	--	solute carrier family 1 (glial high affinity glutamate more	90.73(n) 97.01(a)	541119 XM_614642.3 XP_614642.3
rat (Rattus norvegicus)	Slc1a2¹	--	solute carrier family 1 (glial high affinity glutamate more	88.77(n) 95.64(a)	29482 NM_017215.2 NP_058911.2
mouse (Mus musculus)	Slc1a2^{1, 5}	2 (54.00 cM)⁵	solute carrier family 1 (glial high affinity glutamate more^{1, 5}	88.64(n)¹ 95.45(a)¹	20511¹ NM_001077514.2¹ NP_001070982.1¹ AB007810⁵ AB007811⁵ (see all 18)

About this table Species with no ortholog for SLC1A2

ENSEMBL Gene Tree for SLC1A2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for SLC1A2 gene

SLC1A5² SLC1A4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/888 NCBI SNPs in SLC1A2 are shown (see all 888 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 435)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1570216^1,2	A,C,F,H,O	35238910(-)	`TTTCTA/GTGTTT`	1	--	ut3¹		17	EA NA EU WA	2814
	rs10768122^1,2	A,C,F,H	35237428(+)	`TTCATA/GTAATA`	1	--	ut3¹		14	NA EU EA WA	1250
	rs1923295^1,2	A,C,F,H	35399184(+)	`TCATCC/TTCCAT`	1	--	ng3¹ tfbs³		4	EU EA WA	418
	rs3088168^1,2	A,C,F,H	35229844(+)	`CCATAT/CCTCCT`	1	--	ut3¹		9	MN EU EA WA NA	930
	rs4508184^1,2	A,C,F,H	35238672(+)	`CTGCTT/CTACTC`	1	--	ut3¹		7	NA EU EA WA	558
	rs11033045^1,2	A,C,F,H	35229274(+)	`CTACTA/GTGTAA`	1	--	ng5¹		4	EU EA WA	378
	rs7936950^1,2	C,F,H	35235535(+)	`ACTTCT/CGCAGA`	1	--	ut3¹ ese³		4	EU EA WA	412
	rs10488814^1,2	C,F,H	35237886(+)	`TATAAC/TTGGTT`	1	--	ut3¹		12	NS EU EA WA NA	668
--	rs1321701^1,2	C,F,H	35229181(+)	`TTGCAC/TGATGT`	1	--	ng5¹		7	EU EA NA	500
	rs1043101^1,2	C,F,H	35231405(-)	`GCACAT/CATTTT`	1	--	ut3¹ ese³		11	EU EA WA NA	964

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HapMap Linkage Disequilibrium images for SLC1A2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600300

10/28 Novoseek disease relationships for SLC1A2 gene (see all 28 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
amyotrophic lateral sclerosis	78.34	25	12153483 (2), 9593515 (2), 9771796 (2), 12752781 (2) (see all 18)
neurodegeneration	55.27	5	11790392 (1), 19061913 (1), 15869527 (1), 11071482 (1) (see all 5)
neurological disorders	54.02	4	15869527 (1), 18326497 (1), 17311293 (1), 15804404 (1)
neurodegenerative diseases	49.96	4	9375696 (1), 17517448 (1), 12578975 (1), 9502218 (1)
epilepsy temporal lobe	47.65	3	10336123 (1), 18326497 (1)
gliosis	44.13	2	19151621 (1)
motor neuron disease	43.64	3	9771796 (1), 12752781 (1)
huntington disease	40.78	1	9100675 (1)
glioma	39.20	15	15254085 (2), 12504589 (2), 17311293 (2), 16368696 (1) (see all 8)
epilepsy	38.18	3	14643001 (1), 10336123 (1), 9502218 (1)

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Human Gene Mutation Database: SLC1A2
Genetic Association Database: SLC1A2
Human Genome Epidemiology Navigator: SLC1A2 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/248 PubMed articles for SLC1A2 gene (see all 248 ):

Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. (PubMed id 15296513)^{1, 3, 6} Deng X....Fukumaki Y. (2004)
Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. (PubMed id 7521911)^{1, 3, 4} Arriza J.L.... Amara S.G. (1994)
Cloning and characterization of the 3'-untranslated region of the human excitatory amino acid transporter 2 transcript. (PubMed id 12950454)^{1, 3, 4} Kim S.Y.... Volsky D.J. (2003)
DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. (PubMed id 9463476)^{1, 3, 4} Shimamoto K.... Nakajima T. (1998)
Phosphoproteomic analysis of synaptosomes from human cerebral cortex. (PubMed id 15822905)^{3, 4} DeGiorgis J.A.... Dosemeci A. (2005)
A trimeric quaternary structure is conserved in bacterial and human glutamate transporters. (PubMed id 15265858)^{3, 4} Gendreau S.... Fahlke C. (2004)
Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol dependence. (PubMed id 11204345)^{3, 6} Sander T....Schmidt L.G. (2000)
Molecular cloning of human brain glutamate/aspartate transporter II. (PubMed id 8172925)^{3, 4} Shashidharan P.... Plaitakis A. (1994)
Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas. (PubMed id 7522567)^{3, 4} Manfras B.J.... Boehm B.O. (1994)
Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2). (PubMed id 12578975)^{1, 3} Su Z.Z....Fisher P.B. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6506	HGNC: 10940	AceView: SLC1A2	Ensembl:ENSG00000110436	euGenes: HUgn6506
ECgene: SLC1A2	H-InvDB: SLC1A2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SLC1A2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SLC1A2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SLC1A2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SLC1A2		Antibodies for SLC1A2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SLC1A2		Small molecules for SLC1A2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SLC1A2)
	Antibodies (SLC1A2)
	Chimera RNAi (SLC1A2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for SLC1A2 (EAAT2)

	Recombinant Proteins (EAAT2)
	Antibodies (EAAT2)

Search OriGene for SLC1A2

Tocris compounds for SLC1A2

	Drugs for SLC1A2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SLC1A2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
SLC1A2 Gene at Home site.
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SLC1A2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for SLC1A2

Summaries
for SLC1A2

Genomic Location
for SLC1A2

Proteins
for SLC1A2

Protein Domains/
Families
for SLC1A2

Gene Function
for SLC1A2

Pathways & Interactions
for SLC1A2

Drugs & Compounds
for SLC1A2

Transcripts
for SLC1A2

Expression
for SLC1A2

Orthologs
for SLC1A2

Paralogs
for SLC1A2

SNPs/Variants
for SLC1A2

Disorders & Mutations
for SLC1A2

Medical News
for SLC1A2

Publications
for SLC1A2

Search for SLC1A2

Genome Databases showing SLC1A2

Other Databases showing SLC1A2

Specialized Databases showing SLC1A2

Licensable Technologies
for SLC1A2

Services
for SLC1A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SLC1A2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor SLC1A2

Summariesfor SLC1A2

Genomic Locationfor SLC1A2

Proteinsfor SLC1A2

Protein Domains/Familiesfor SLC1A2

Gene Functionfor SLC1A2

Pathways & Interactionsfor SLC1A2

Drugs & Compoundsfor SLC1A2

Transcriptsfor SLC1A2

Expression for SLC1A2

Orthologsfor SLC1A2

Paralogsfor SLC1A2

SNPs/Variantsfor SLC1A2

Disorders & Mutationsfor SLC1A2

Medical Newsfor SLC1A2

Publicationsfor SLC1A2

Search for SLC1A2

Genome Databases showing SLC1A2

Other Databases showing SLC1A2

Specialized Databases showing SLC1A2

Licensable Technologiesfor SLC1A2

Servicesfor SLC1A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SLC1A2

Summaries
for SLC1A2

Genomic Location
for SLC1A2

Proteins
for SLC1A2

Protein Domains/
Families
for SLC1A2

Gene Function
for SLC1A2

Pathways & Interactions
for SLC1A2

Drugs & Compounds
for SLC1A2

Transcripts
for SLC1A2

Expression
for SLC1A2

Orthologs
for SLC1A2

Paralogs
for SLC1A2

SNPs/Variants
for SLC1A2

Disorders & Mutations
for SLC1A2

Medical News
for SLC1A2

Publications
for SLC1A2

Licensable Technologies
for SLC1A2

Services
for SLC1A2