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Aliases for SLC1A2 Gene

Aliases for SLC1A2 Gene

  • Solute Carrier Family 1 Member 2 2 3 4
  • Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 2 3 5
  • Sodium-Dependent Glutamate/Aspartate Transporter 2 3 4
  • Glutamate/Aspartate Transporter II 3 4
  • EAAT2 3 4
  • Excitotoxic Amino Acid Transporter 2 3
  • GLT-1 3
  • HBGT 3
  • GLT1 4

External Ids for SLC1A2 Gene

Previous GeneCards Identifiers for SLC1A2 Gene

  • GC11M036834
  • GC11M035960
  • GC11M035315
  • GC11M035246
  • GC11M035237
  • GC11M035229
  • GC11M034972

Summaries for SLC1A2 Gene

Entrez Gene Summary for SLC1A2 Gene

  • This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for SLC1A2 Gene

SLC1A2 (Solute Carrier Family 1 Member 2) is a Protein Coding gene. Diseases associated with SLC1A2 include leukomalacia and hepatic encephalopathy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neurotransmitter Release Cycle. GO annotations related to this gene include L-glutamate transmembrane transporter activity and glutamate:sodium symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A2 Gene

  • Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Tocris Summary for SLC1A2 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.

Gene Wiki entry for SLC1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A2 Gene

Genomics for SLC1A2 Gene

Genomic Location for SLC1A2 Gene

Chromosome:
11
Start:
35,251,205 bp from pter
End:
35,420,063 bp from pter
Size:
168,859 bases
Orientation:
Minus strand

Genomic View for SLC1A2 Gene

Genes around SLC1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A2 Gene

Proteins for SLC1A2 Gene

  • Protein details for SLC1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43004-EAA2_HUMAN
    Recommended name:
    Excitatory amino acid transporter 2
    Protein Accession:
    P43004
    Secondary Accessions:
    • B4DQE9
    • Q14417
    • Q541G6
    • U3KQQ4

    Protein attributes for SLC1A2 Gene

    Size:
    574 amino acids
    Molecular mass:
    62104 Da
    Quaternary structure:
    • Homotrimer. Isoform 3 can oligomerize with isoform 1. Interacts with AJUBA (By similarity).

    Alternative splice isoforms for SLC1A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A2 Gene

Proteomics data for SLC1A2 Gene at MOPED

Post-translational modifications for SLC1A2 Gene

  • Glycosylated.
  • Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.
  • Glycosylation at Asn 206 and Asn 216
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC1A2 (GLT1)

No data available for DME Specific Peptides for SLC1A2 Gene

Domains & Families for SLC1A2 Gene

Gene Families for SLC1A2 Gene

Protein Domains for SLC1A2 Gene

Graphical View of Domain Structure for InterPro Entry

P43004

UniProtKB/Swiss-Prot:

EAA2_HUMAN :
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A2 subfamily.
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A2 subfamily.
genes like me logo Genes that share domains with SLC1A2: view

Function for SLC1A2 Gene

Molecular function for SLC1A2 Gene

GENATLAS Biochemistry:
solute carrier family 1,member A2,glial high affinity glutamate transporter,expressed in brain and pancreas,located in astrocytes,with five transcripts alternatively spliced from 5utr and a variant acting as a putative modifier for the spastic paraplegia phenotype
UniProtKB/Swiss-Prot Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Gene Ontology (GO) - Molecular Function for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005314 high-affinity glutamate transmembrane transporter activity TAS --
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0017153 sodium:dicarboxylate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A2: view
genes like me logo Genes that share phenotypes with SLC1A2: view

Animal Models for SLC1A2 Gene

MGI Knock Outs for SLC1A2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC1A2 Gene

Localization for SLC1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A2 Gene COMPARTMENTS Subcellular localization image for SLC1A2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SLC1A2 Gene

Pathways & Interactions for SLC1A2 Gene

genes like me logo Genes that share pathways with SLC1A2: view

Gene Ontology (GO) - Biological Process for SLC1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport IEA --
GO:0007268 synaptic transmission TAS 7521911
GO:0007269 neurotransmitter secretion TAS --
GO:0010259 multicellular organism aging IEA --
genes like me logo Genes that share ontologies with SLC1A2: view

No data available for SIGNOR curated interactions for SLC1A2 Gene

Drugs & Compounds for SLC1A2 Gene

(30) Drugs for SLC1A2 Gene - From: IUPHAR, DGIdb, Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dihydrokainate Pharma Inhibition, Inhibitor 0
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
[<sup>3</sup>H](2S,4R)-4-methylglutamate Pharma 0
[<sup>3</sup>H]D-aspartic acid Pharma 0
[<sup>3</sup>H]L-aspartic acid Pharma 0

(27) Additional Compounds for SLC1A2 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
[<sup>3</sup>H]ETB-TBOA
7-Chlorokynurenic acid
18000-24-3
cis-ACBD
73550-55-7
Dihydrokainic acid
52497-36-6
genes like me logo Genes that share compounds with SLC1A2: view

Transcripts for SLC1A2 Gene

Unigene Clusters for SLC1A2 Gene

Solute carrier family 1 (glial high affinity glutamate transporter), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -

Relevant External Links for SLC1A2 Gene

GeneLoc Exon Structure for
SLC1A2
ECgene alternative splicing isoforms for
SLC1A2

Expression for SLC1A2 Gene

mRNA expression in normal human tissues for SLC1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC1A2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x8.3), Brain - Nucleus accumbens (basal ganglia) (x7.7), Brain - Amygdala (x7.5), Brain - Putamen (basal ganglia) (x7.2), Brain - Frontal Cortex (BA9) (x4.9), Brain - Cortex (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for SLC1A2 Gene

This gene is overexpressed in Frontal cortex (33.3) and Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC1A2 Gene



SOURCE GeneReport for Unigene cluster for SLC1A2 Gene Hs.502338

genes like me logo Genes that share expression patterns with SLC1A2: view

Protein tissue co-expression partners for SLC1A2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC1A2 Gene

Orthologs for SLC1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A2 36
  • 100 (a)
OneToOne
SLC1A2 35
  • 99.59 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SLC1A2 35
  • 90.71 (n)
  • 97.04 (a)
SLC1A2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A2 36
  • 91 (a)
OneToOne
SLC1A2 35
  • 91.37 (n)
  • 96.63 (a)
mouse
(Mus musculus)
Mammalia Slc1a2 16
Slc1a2 36
  • 95 (a)
OneToOne
Slc1a2 35
  • 88.64 (n)
  • 95.45 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC1A2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a2 35
  • 88.77 (n)
  • 95.64 (a)
chicken
(Gallus gallus)
Aves SLC1A2 35
  • 78.76 (n)
  • 88.77 (a)
SLC1A2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a2 35
  • 75.91 (n)
  • 85.16 (a)
zebrafish
(Danio rerio)
Actinopterygii slc1a2a 36
  • 78 (a)
OneToMany
slc1a2b 36
  • 78 (a)
OneToMany
slc1a9 36
  • 49 (a)
OneToMany
slc1a2b 35
  • 72.1 (n)
  • 79.93 (a)
wufj34b12 35
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 37
  • 43 (a)
Eaat2 37
  • 43 (a)
Eaat2 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea glt-1 35
  • 58.47 (n)
  • 61.46 (a)
glt-1 36
  • 58 (a)
OneToMany
glt-3 36
  • 46 (a)
OneToMany
glt-5 36
  • 50 (a)
OneToMany
glt-6 36
  • 43 (a)
OneToMany
glt-7 36
  • 36 (a)
OneToMany
glt-2 37
  • 62 (a)
K08F4.4 37
  • 50 (a)
R05G6.6 37
  • 43 (a)
T22E5.2 37
  • 44 (a)
W03G1.1 37
  • 34 (a)
Y53C12A.2 37
  • 51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5947 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.317 36
  • 43 (a)
OneToOne
Species with no ortholog for SLC1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A2 Gene

ENSEMBL:
Gene Tree for SLC1A2 (if available)
TreeFam:
Gene Tree for SLC1A2 (if available)

Paralogs for SLC1A2 Gene

Paralogs for SLC1A2 Gene

(6) SIMAP similar genes for SLC1A2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC1A2: view

Variants for SLC1A2 Gene

Sequence variations from dbSNP and Humsavar for SLC1A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs752949 -- 35,306,201(+) TCGTC(C/T)GGCGG reference, synonymous-codon
rs764750 -- 35,391,683(-) TAAAA(C/G)AGCAG intron-variant
rs911561 -- 35,377,563(+) TGGCT(A/G)TGTCA intron-variant
rs911562 -- 35,377,806(+) GAACA(A/G)AAAGA intron-variant
rs1126356 -- 35,404,514(+) TGTTA(C/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A2 Gene

Variant ID Type Subtype PubMed ID
nsv7733 CNV Insertion 18451855
nsv832120 CNV Gain 17160897
esv269007 CNV Insertion 20981092
essv13578 CNV CNV 17122850
esv2602066 CNV Insertion 19546169

Variation tolerance for SLC1A2 Gene

Residual Variation Intolerance Score: 9.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC1A2 Gene

HapMap Linkage Disequilibrium report
SLC1A2
Human Gene Mutation Database (HGMD)
SLC1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A2 Gene

Disorders for SLC1A2 Gene

MalaCards: The human disease database

(19) MalaCards diseases for SLC1A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukomalacia
hepatic encephalopathy
  • portal-systemic encephalopathy
periventricular leukomalacia
  • periventricular leucomalacia
neuromyelitis optica
  • devic's disease
temporal lobe epilepsy
  • epilepsy, temporal lobe
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC1A2

Genetic Association Database (GAD)
SLC1A2
Human Genome Epidemiology (HuGE) Navigator
SLC1A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC1A2
genes like me logo Genes that share disorders with SLC1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC1A2 Gene

Publications for SLC1A2 Gene

  1. No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia. (PMID: 19660525) Nagai Y. … Arai H. (Neurosci. Lett. 2009) 3 23 48 67
  2. Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium. (PMID: 19283393) Beschorner R. … Schittenhelm J. (Acta Neuropathol. 2009) 3 23
  3. Regulation of the glutamate transporter EAAT2 by PIKfyve. (PMID: 19910676) Gehring E.M. … Lang F. (Cell. Physiol. Biochem. 2009) 3 23
  4. Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia. (PMID: 18314905) Desilva T.M. … Rosenberg P.A. (J. Comp. Neurol. 2008) 3 23
  5. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. (PMID: 18326497) Lee S.G. … Fisher P.B. (J. Biol. Chem. 2008) 3 23

Products for SLC1A2 Gene

Sources for SLC1A2 Gene

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