Aliases for SLC1A1 Gene
- Solute Carrier Family 1 (Neuronal/Epithelial High Affinity Glutamate Transporter, System Xag), Member 1 2 3
- Sodium-Dependent Glutamate/Aspartate Transporter 3 3 4
- Neuronal And Epithelial Glutamate Transporter 3 4
- Solute Carrier Family 1 Member 1 3 4
- EAAC1 3 4
- EAAT3 3 4
- Excitatory Amino Acid Transporter 3 3
External Ids for SLC1A1 Gene
Previous GeneCards Identifiers for SLC1A1 Gene
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
GeneCards Summary for SLC1A1 Gene
SLC1A1 (Solute Carrier Family 1 (Neuronal/Epithelial High Affinity Glutamate Transporter, System Xag), Member 1) is a Protein Coding gene. Diseases associated with SLC1A1 include dicarboxylic aminoaciduria and schizophrenia susceptibility 18. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include L-glutamate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC1A3.
UniProtKB/Swiss-Prot for SLC1A1 Gene
Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.