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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC19A3 Gene

protein-coding GIFtS: 56
GCID: GC02M228513

solute carrier family 19, member 3

Explore 13 diseases affiliated with
SLC19A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 19, Member 3¹ ²		Thiamine Transporter 2²
THTR2¹ ²		ThTr-2³
BBGD²		ThTr2³
THMD2²		Solute Carrier Family 19 Member 3³
ThTr-2³

External Ids:	HGNC: 16266¹	Entrez Gene: 80704²	Ensembl: ENSG00000135917⁷	OMIM: 606152⁵	UniProtKB: Q9BZV2³

Export aliases for SLC19A3 gene to outside databases

Previous GC identifers: GC02M226571 GC02M227281 GC02M228752 GC02M228375 GC02M228258 GC02M220392

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC19A3:

This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity.

Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in

childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with

BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of

biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in

residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment

of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also

cause a Wernicke's-like encephalopathy.(provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: S19A3_HUMAN, Q9BZV2

Function: Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport

activity

Gene Wiki entry for SLC19A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC19A3 gene promoter:
FOXD3 CUTL1 HNF-3beta NF-kappaB NF-AT E47 C/EBPalpha NF-kappaB2 Hand1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC19A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC19A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC19A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q37

SLC19A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC19A3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M228513: view genomic region (about GC identifiers)

Start:	228,549,926 bp from pter	End:	228,582,745 bp from pter
Size:	32,820 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S19A3_HUMAN, Q9BZV2 (See protein sequence)

Recommended Name: Thiamine transporter 2

Size: 496 amino acids; 55665 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for SLC19A3: NX_Q9BZV2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BZV2

SLC19A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079519.1

ENSEMBL proteins:

ENSP00000397393 ENSP00000386298 ENSP00000258403 ENSP00000399001 ENSP00000400627

ENSP00000398349 ENSP00000387193 ENSP00000445519

Reactome Protein details: Q9BZV2
Human Recombinant Protein Products for SLC19A3:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC19A3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	NAS	11136550

SLC19A3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC19A3 for domains About GeneDecksing

2 InterPro domains/families:

IPR002666 Folate_carrier

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q9BZV2

ProtoNet protein and cluster: Q9BZV2

1 Blocks protein family: IPB002666 Reduced folate carrier

UniProtKB/Swiss-Prot: S19A3_HUMAN, Q9BZV2

Similarity: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S19A3_HUMAN, Q9BZV2

Function: Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport

activity

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005542	folic acid binding	IEA	--
GO:0008518	reduced folate carrier activity	IEA	--
GO:0015403	thiamine uptake transmembrane transporter activity	ISS	--

SLC19A3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLC19A3:

Increased S DNA content

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc19a3):

behavior/neurological	digestive/alimentary	growth/size	homeostasis/metabolism	immune system
liver/biliary system	mortality/aging	renal/urinary system

SLC19A3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Slc19a3^tm1Said for SLC19A3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC19A3

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		hsa-miR-4310 hsa-miR-3613-3p hsa-miR-630 hsa-miR-548c-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SLC19A3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC19A3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Vitamin B5 (pantothenate) metabolism

Metabolism of vitamins and cofactors

0.21

Metabolism of water-soluble vitamins and cofactors

0.21

Vitamin B1 (thiamin) metabolism

Vitamin B1 (thiamin) metabolism

1.00

Vitamin digestion and absorption

Vitamin digestion and absorption

1.00

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLC19A3

	Vitamin B1 (thiamin) metabolism
	Metabolism
	Metabolism of vitamins and cofactors
	Metabolism of water-soluble vitamins and cofactors

1 Kegg Pathway (Kegg details for SLC19A3):

Vitamin digestion and absorption

SLC19A3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC19A3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for SLC19A3 (Q9BZV2³ ENSP00000258403⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREB3	O43889³	I2D: score=1
TPK1	ENSP00000353165⁴	STRING: ENSP00000353165
C3orf38	ENSP00000322469⁴	STRING: ENSP00000322469
CREB3L4	ENSP00000271889⁴	STRING: ENSP00000271889
TAB2	ENSP00000286332⁴	STRING: ENSP00000286332

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006766	vitamin metabolic process	TAS	--
GO:0006767	water-soluble vitamin metabolic process	TAS	--
GO:0006810	transport	NAS	--
GO:0042723	thiamine-containing compound metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

SLC19A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC19A3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC19A3

1 DrugBank Compound for SLC19A3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Cysteine	(R)-2-Amino-3-mercaptopropanoic acid (see all 13)	52-90-4	target	--	17139284 17016423

1 Novoseek chemical compound relationship for SLC19A3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thiamine	82.9	17	16206251 (3), 16055442 (3), 12861052 (1), 12488043 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about SLC19A3 / S19A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC19A3 gene:

NM_025243.3

Unigene Cluster for SLC19A3:

Solute carrier family 19, member 3

Hs.221597 [show with all ESTs]

Unigene Representative Sequence: NM_025243

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000425817(uc002vpi.3 uc002vpj.3) ENST00000409287 ENST00000258403(uc010zlv.1)

ENST00000456524 ENST00000431622 ENST00000419059 ENST00000409456 ENST00000477697

ENST00000541617

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Additional cDNA sequence:

AF271633.1 AK301490.1 AK312464.1 BC032014.1

6 DOTS entries:

DT.426047 DT.430182 DT.105803 DT.40129849 DT.91673514 DT.97795633

24/52 AceView cDNA sequences (see all 52):

CR609013 BQ716625 BC032014 AA570151 AF271633 CR595614 BG743421 BM924450

AA777563 CB997135 CB988123 CF529586 BX327338 BU617459 BX399578 AI056985

BX381823 H49809 BI821647 BM992423 AI671566 BV205778 BX486358 BG433005

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC19A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SLC19A3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC19A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC19A3

SOURCE GeneReport for Unigene cluster: Hs.221597

UniProtKB/Swiss-Prot: S19A3_HUMAN, Q9BZV2

Tissue specificity: Widely expressed but most abundant in placenta, kidney and liver

SABiosciences Expression via Pathway-Focused PCR Array including SLC19A3:

Drug Transporters in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC19A3 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC19A3¹	solute carrier family 19, member 3	64.55(n) 62.37(a)		424792 XM_422610.3 XP_422610.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	67(a) 66(a)	1 ↔ many 1 ↔ many	3(23337258-23352975) 3(23353084-23359391)
African clawed frog (Xenopus laevis)	Amphibia	MGC52872²	similar to solute carrier family 19, member 3	75.02(n)		BC043746.1
zebrafish (Danio rerio)	Actinopterygii	LOC557854¹	thiamine transporter 2-like	55.28(n) 48.12(a)		557854 XM_680999.4 XP_686091.3
fruit fly (Drosophila melanogaster)	Insecta	CG17036³ CG6574¹	reduced folate carrier³ CG6574¹	36(a) (best of 3)³ 49(n)¹ 36.34(a)¹		33F3³ 41308¹ NM_141772.3¹ NP_650029.1¹
worm (Caenorhabditis elegans)	Secernentea	F37B4.7³	folate transporter	32(a) (best of 2)		V(2872542-2875305) --

ENSEMBL Gene Tree for SLC19A3 (if available)
TreeFam Gene Tree for SLC19A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC19A3 gene

SLC19A1² SLC19A2²

2 SIMAP similar genes for SLC19A3 using alignment to 7 protein entries: S19A3_HUMAN (see all proteins):

SLC19A2 SLC19A1

SLC19A3 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for SLC19A3
PGOHUM00000240541 PGOHUM00000243684 PGOHUM00000233238

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121917882^1,2	C	pathogenic	228566967(-)	`ATTTGG/TTTTTT`	2	G V	mis¹		0	--	--	--	--
rs190011414^1,2		--	228549469(+)	`CGAGAC/TGGGCG`	1	--	ds500¹		0	--	--	--	--
rs112334929^1,2		--	228549473(+)	`ACGGGC/TGGATC`	1	--	ds500¹		2		CSA NA	121
rs192860944^1,2		--	228549488(+)	`GAGACC/TAGGAG`	1	--	ds500¹		0	--	--	--	--
rs113499955^1,2		--	228549567(+)	`GGTGGC/TGCACG`	1	--	ds500¹		1		CSA	1
rs35555555^1,2	C,F	--	228549571(+)	`GTGCAT/CGCCTG`	1	--	ds500¹		4		NA	8
rs112697749^1,2		--	228549592(+)	`TACTCA/GGGAGG`	1	--	ds500¹		1		CSA	1
rs184846680^1,2		--	228549615(+)	`AATTGC/TTTGAA`	1	--	ds500¹		0	--	--	--	--
rs189985829^1,2		--	228549645(+)	`AGTGAA/GCTGAC`	1	--	ds500¹		0	--	--	--	--
rs78632389^1,2		--	228549744(+)	`ATAGCA/GGCCAT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC19A3 (228549926 - 228582745 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC19A3: --
Human Gene Mutation Database (HGMD): SLC19A3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC19A3

DNA2.0 Custom Variant and Variant Library Synthesis for SLC19A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC19A3 for disorders           About GeneDecksing

OMIM gene information: 606152
OMIM disorders: 607483
UniProtKB/Swiss-Prot: S19A3_HUMAN, Q9BZV2

Defects in SLC19A3 are the cause of thiamine metabolism dysfunction syndrome 2, biotin- or thiamine-responsive

type (THMD2) [MIM:607483]. An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often

triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes

coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic

bilateral lesions of the basal ganglia

13 diseases for SLC19A3: About MalaCards

biotin-responsive basal ganglia disease basal ganglia disease encephalopathy, thiamine-responsive thiamine-responsive megaloblastic anemia syndrome

wernicke-korsakoff syndrome megaloblastic anemia wernicke encephalopathy anemia

gastric cancer breast cancer hypoxia retinitis

pancreatitis

4 diseases from the University of Copenhagen DISEASES database for SLC19A3:

biotin-responsive basal ganglia disease Wernicke-Korsakoff syndrome Megaloblastic anemia Wernicke encephalopathy

Export disorders for SLC19A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC19A3 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with SLC19A3)

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Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. (PubMed id 11136550)^{1, 2, 3, 9} Eudy J.D....Finnell R.H. (2000)
Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3. (PubMed id 15871139)^{1, 2, 3} Zeng W.-Q.... Gusella J.F. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
SLC19: the folate/thiamine transporter family. (PubMed id 14770311)^{1, 2} Ganapathy V.... Prasad P.D. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
SLC19A3 encodes a second thiamine transporter ThTr2. (PubMed id 11731220)^{1, 2} Rajgopal A.... Zhao R. (2001)
Characterization of the 5'-regulatory region of the human thiamin transporter SLC19A3: in vitro and in vivo studies. (PubMed id 15217784)^{1, 9} Nabokina S.M. and Said H.M. (2004)
Differentiation-dependent up-regulation of intestinal thiamin uptake: cellular and molecular mechanisms. (PubMed id 16055442)^{1, 9} Nabokina S.M....Said H.M. (2005)
Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood. (PubMed id 15623830)^{1, 9} Vlasova T.I....Mock D.M. (2005)
Down-regulation of thiamine transporter THTR2 gene expression in breast cancer and its association with resistance to apoptosis. (PubMed id 12861052)^{1, 9} Liu S....Moscow J.A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80704	HGNC: 16266	AceView: SLC19A3	Ensembl:ENSG00000135917	euGenes: HUgn80704
ECgene: SLC19A3	Kegg: 80704	H-InvDB: SLC19A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC19A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC19A3 gene
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Patent Information for SLC19A3 gene:
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SLC19A3 Gene

solute carrier family 19, member 3

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SLC19A3 Gene

solute carrier family 19, member 3

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