Aliases for SLC19A1 Gene
External Ids for SLC19A1 Gene
Previous GeneCards Identifiers for SLC19A1 Gene
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
GeneCards Summary for SLC19A1 Gene
SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC19A1 include methotrexate dose selection and thiamine-responsive megaloblastic anemia syndrome. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include folic acid binding and reduced folate carrier activity. An important paralog of this gene is SLC19A2.
UniProtKB/Swiss-Prot for SLC19A1 Gene
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump