Aliases for SLC19A1 Gene
External Ids for SLC19A1 Gene
Previous GeneCards Identifiers for SLC19A1 Gene
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
GeneCards Summary for SLC19A1 Gene
SLC19A1 (Solute Carrier Family 19 Member 1) is a Protein Coding gene. Diseases associated with SLC19A1 include Placental Choriocarcinoma and Methotrexate Toxicity Or Dose Selection. Among its related pathways are Vitamin digestion and absorption and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include oxidoreductase activity and folic acid transporter activity. An important paralog of this gene is SLC19A3.
UniProtKB/Swiss-Prot for SLC19A1 Gene
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.