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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC18B1 Gene

protein-coding   GIFtS: 39
GCID: GC06M133090

solute carrier family 18, subfamily B, member 1

(Previous name: chromosome 6 open reading frame 192 )
(Previous symbol: C6orf192)
  Search for SLC18B1
in
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 Human Malady Compendium 
Biological research products
for SLC18B1    

Aliases
for SLC18B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 18, Subfamily B, Member 11 2     Chromosome 6 Open Reading Frame 1921
C6orf1921 2 3 5     MFS-Type Transporter C6orf1922
DJ55C23.61     MFS-Type Transporter SLC18B12
Solute Carrier Family 18 Member B12 3     

External Ids:    HGNC: 215731   Entrez Gene: 1168432   Ensembl: ENSG000001464097   OMIM: 6133615   UniProtKB: Q6NT163   

Export aliases for SLC18B1 gene to outside databases


Summaries
for SLC18B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC18B1:
This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein
function is unknown. (provided by RefSeq, Jul 2008)




Genomic Views
for SLC18B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC18B1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC18B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC18B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC18B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.3-q23.3   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q22.3-q23.3

SLC18B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC18B1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M133090:  view genomic region     (about GC identifiers)

Start:
 133,090,507 bp from pter      End:
 133,119,747 bp from pter
Size:
 29,241 bases      Orientation:
 minus strand

Proteins
for SLC18B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S18B1_HUMAN, Q6NT16 (See protein sequence)
Recommended Name: MFS-type transporter SLC18B1  
Size: 456 amino acids; 48869 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8K1K3 B3KW77 Q6ISF2

Explore the universe of human proteins at neXtProt for SLC18B1: NX_Q6NT16

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6NT16

    • SLC18B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_439896.1  
    ENSEMBL proteins: 
     ENSP00000275227   ENSP00000356895   ENSP00000444098  

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    Uscn Proteins for SLC18B1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    SLC18B1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC18B1

    Protein Domains /
    Families
    for SLC18B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC18B1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q6NT16

    ProtoNet protein and cluster: Q6NT16

    UniProtKB/Swiss-Prot: S18B1_HUMAN, Q6NT16
    Similarity: Belongs to the major facilitator superfamily


    Function
    for SLC18B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SLC18B1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SLC18B1

    In Situ Assay
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    Pathways & Interactions
    for SLC18B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC18B1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC18B1 (ENSP000002752274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport IEA--


    SLC18B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC18B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC18B1
    Search CenterWatch for drugs/clinical trials and news about SLC18B1 / S18B1 

    Transcripts
    for SLC18B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC18B1 gene: 
    NM_052831.2  

    Unigene Cluster for SLC18B1:

    Solute carrier family 18, subfamily B, member 1
    Hs.347144  [show with all ESTs]
    Unigene Representative Sequence: NM_052831
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275227(uc010kgd.1 uc003qdw.1) ENST00000367918 ENST00000460518
    ENST00000538764(uc011eco.1)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: SLC18B1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC18B1 (see all 4)
    OriGene shRNA RFP: SLC18B1
    OriGene siRNA: SLC18B1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC18B1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ420537.1 AK124442.1 AK289918.1 AK293853.1 BC069567.1 BC069570.1 

    6 DOTS entries:

    DT.95236139  DT.100813979  DT.100027961  DT.100813981  DT.100813980  DT.91906066 

    24/114 AceView cDNA sequences (see all 114):

    BM739172 AI141255 CB111150 BM014614 CA431238 BM968525 BX096198 AJ420537 
    CA310520 CB111357 AW515598 NM_052831 CB109388 AW513193 CB109893 AK124442 
    CB109419 CA389091 BG498269 BI753733 CB120195 BC069567 AI658882 AA449366 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC18B1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                                        -                       -           -     -           -                           
    SP2:                                                        -                       -           -     -                                       
    SP3:                                                                                -     -           -           -                           
    SP4:                                                                                            -     -           -                           
    SP5:                                                                                -     -                                                   


    ECgene alternative splicing isoforms for SLC18B1

    Expression
    for SLC18B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC18B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTTGTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC18B1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC18B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC18B1

    SOURCE GeneReport for Unigene cluster: Hs.347144
        SABiosciences Custom PCR Arrays for SLC18B1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18B1

    Orthologs
    for SLC18B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC18B1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves C3H6orf1921 chromosome 3 open reading frame, human C6orf192 68(n)
    69.4(a)    		   421699  XM_419737.3  XP_419737.3 
    lizard
    (Anolis carolinensis)    		 Reptilia C6orf1926
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343200.1(4388092-4415141)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.182112 Transcribed sequence with weak similarity to protein more 73.96(n)    AL972629.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii slc18b11 solute carrier family 18, subfamily B, member 1 60.53(n)
    55.19(a)    		   550539  NM_001017841.1  NP_001017841.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0019801 AGAP001980-PB 45.36(n)
    37.43(a)    		   1281142  XM_321082.4  XP_321082.4 
    worm
    (Caenorhabditis elegans)    		 Secernentea F55A4.81 Protein F55A4.8 47.28(n)
    37.96(a)    		   180457  NM_171625.3  NP_741717.1 


    ENSEMBL Gene Tree for SLC18B1 (if available)
    TreeFam Gene Tree for SLC18B1 (if available) 

    Paralogs
    for SLC18B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC18B1 gene
    SLC18A22  SLC18A12  SLC18A32  

    SLC18B1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC18B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/700 NCBI SNPs in SLC18B1 are shown (see all 700)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs119626971,2
    		C,F,H,--133090067(+) CAAACC/TTCATC 1 -- ds500112Minor allele frequency- T:0.08NS EA NA WA CSA 1216
    rs735485341,2
    		C,--133090099(+) TGCACG/ATACTA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs14674041,2
    		C,F,O,A,H,--133090141(+) TACATC/TCTCTT 1 -- ds500137Minor allele frequency- T:0.26NS EA NA WA CSA 3531
    rs2000837961,2
    		--133090246(+) CCATG-/TTTTTT 1 -- ds50010--------
    rs119627771,2
    		C,F,A,H,--133090309(+) TTGTTC/TGTCTC 1 -- ds500113Minor allele frequency- T:0.06NS EA NA WA CSA 1550
    rs1863721301,2
    		C,--133090401(+) AGCTCA/GGAGAA 1 -- ds50010--------
    rs1143952181,2
    		--133090419(+) AAAAGA/TTATTT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1908899331,2
    		--133090476(+) AATGTA/GGCTAC 1 -- ds50010--------
    rs1823635451,2
    		--133090558(+) TCACAC/TGAAGT 1 -- ut310--------
    rs1125194551,2
    		--133090567(+) GTTGGG/AGGAAG 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for SLC18B1 (133090507 - 133119747 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC18B1: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SLC18B1

    Disorders / Diseases
    for SLC18B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC18B1 for disorders           About MalaCards

    SLC18B1 for disorders           About GeneDecksing

    OMIM gene information: 613361    OMIM disorders: --


    Export disorders for SLC18B1 gene to outside databases

    Publications
    for SLC18B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC18B1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC18B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. C6ORF192 forms a unique evolutionary branch among sol ute carriers (SLC16, SLC17, and SLC18) and is abundantly expressed in several b rain regions. (PubMed id 19697161)1, 3 Jacobsson J.A....Fredriksson R. (2010)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SLC18B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SLC18B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116843 HGNC: 21573 AceView: C6orf192 Ensembl:ENSG00000146409 euGenes: HUgn116843
    ECgene: SLC18B1 H-InvDB: SLC18B1

    Other Databases showing SLC18B1 gene

    (According to HUGE)
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    Specialized Databases showing SLC18B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC18B1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC18B1 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC18B1 gene:
    Search GeneIP for patents involving SLC18B1

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