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Aliases for SLC18B1 Gene

Aliases for SLC18B1 Gene

  • Solute Carrier Family 18 Member B1 2 3 4
  • Solute Carrier Family 18, Subfamily B, Member 1 2 3 5
  • C6orf192 3 4
  • Chromosome 6 Open Reading Frame 192 2
  • MFS-Type Transporter C6orf192 3
  • DJ55C23.6 3

External Ids for SLC18B1 Gene

Previous HGNC Symbols for SLC18B1 Gene

  • C6orf192

Previous GeneCards Identifiers for SLC18B1 Gene

  • GC06M133090

Summaries for SLC18B1 Gene

Entrez Gene Summary for SLC18B1 Gene

  • This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC18B1 Gene

SLC18B1 (Solute Carrier Family 18 Member B1) is a Protein Coding gene. An important paralog of this gene is SLC18A2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC18B1 Gene

Genomics for SLC18B1 Gene

Regulatory Elements for SLC18B1 Gene

Enhancers for SLC18B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC18B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC18B1 Gene

132,769,368 bp from pter
132,804,931 bp from pter
35,564 bases
Minus strand

Genomic View for SLC18B1 Gene

Genes around SLC18B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC18B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC18B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC18B1 Gene

Proteins for SLC18B1 Gene

  • Protein details for SLC18B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MFS-type transporter SLC18B1
    Protein Accession:
    Secondary Accessions:
    • A8K1K3
    • B3KW77
    • Q6ISF2

    Protein attributes for SLC18B1 Gene

    456 amino acids
    Molecular mass:
    48869 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC18B1 Gene

Proteomics data for SLC18B1 Gene at MOPED

Post-translational modifications for SLC18B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC18B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC18B1 Gene

Domains & Families for SLC18B1 Gene

Gene Families for SLC18B1 Gene

Protein Domains for SLC18B1 Gene


Suggested Antigen Peptide Sequences for SLC18B1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SLC18B1: view

Function for SLC18B1 Gene

genes like me logo Genes that share phenotypes with SLC18B1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC18B1 Gene

Localization for SLC18B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC18B1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC18B1 Gene COMPARTMENTS Subcellular localization image for SLC18B1 gene
Compartment Confidence
plasma membrane 3
cytosol 2
golgi apparatus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC18B1 Gene

Pathways & Interactions for SLC18B1 Gene

SuperPathways for SLC18B1 Gene

No Data Available

Interacting Proteins for SLC18B1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000275227 for SLC18B1 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC18B1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC18B1 Gene

Drugs & Compounds for SLC18B1 Gene

No Compound Related Data Available

Transcripts for SLC18B1 Gene

Unigene Clusters for SLC18B1 Gene

Solute carrier family 18, subfamily B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC18B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for SLC18B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC18B1 Gene

mRNA expression in normal human tissues for SLC18B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC18B1 Gene

This gene is overexpressed in CD8 Tcells (25.1), Frontal cortex (20.9), and Blymphocyte (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC18B1 Gene

SOURCE GeneReport for Unigene cluster for SLC18B1 Gene Hs.347144

genes like me logo Genes that share expression patterns with SLC18B1: view

Protein tissue co-expression partners for SLC18B1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC18B1 Gene

Orthologs for SLC18B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC18B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC18B1 35
  • 85.71 (n)
  • 83.3 (a)
SLC18B1 36
  • 82 (a)
(Canis familiaris)
Mammalia SLC18B1 35
  • 86.29 (n)
  • 85.68 (a)
SLC18B1 36
  • 85 (a)
(Mus musculus)
Mammalia Slc18b1 35
  • 81.01 (n)
  • 81.15 (a)
Slc18b1 16
Slc18b1 36
  • 79 (a)
(Pan troglodytes)
Mammalia SLC18B1 35
  • 99.63 (n)
  • 99.34 (a)
SLC18B1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc18b1 35
  • 81.01 (n)
  • 80.27 (a)
(Monodelphis domestica)
Mammalia SLC18B1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 74 (a)
(Gallus gallus)
Aves C6ORF192 35
  • 68 (n)
  • 69.4 (a)
C6ORF192 36
  • 68 (a)
(Anolis carolinensis)
Reptilia SLC18B1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc18b1 35
  • 64.95 (n)
  • 63.23 (a)
Str.18211 35
(Danio rerio)
Actinopterygii slc18b1 35
  • 60.55 (n)
  • 55.06 (a)
slc18b1 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001980 35
  • 45.84 (n)
  • 37.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta prt 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea F55A4.8 35
  • 47.28 (n)
  • 37.96 (a)
F55A4.8 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for SLC18B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC18B1 Gene

Gene Tree for SLC18B1 (if available)
Gene Tree for SLC18B1 (if available)

Paralogs for SLC18B1 Gene

Paralogs for SLC18B1 Gene

genes like me logo Genes that share paralogs with SLC18B1: view

Variants for SLC18B1 Gene

Sequence variations from dbSNP and Humsavar for SLC18B1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6926101 - 132,783,981(+) AACGA(C/T)GCATC reference, missense
rs59989552 - 132,798,425(+) GTGCG(A/C)GTGGT intron-variant, reference, missense
rs41286192 - 132,797,077(+) TCTCG(A/G)AAGCC reference, missense, utr-variant-5-prime
rs1046448 -- 132,770,238(+) CATTT(A/C)TCAAC utr-variant-3-prime
rs1063172 -- 132,770,016(+) CTTGT(A/T)TTGTT utr-variant-3-prime

Variation tolerance for SLC18B1 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SLC18B1 Gene

Disorders for SLC18B1 Gene

Relevant External Links for SLC18B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC18B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC18B1 Gene

Publications for SLC18B1 Gene

  1. C6ORF192 forms a unique evolutionary branch among solute carriers (SLC16, SLC17, and SLC18) and is abundantly expressed in several brain regions. (PMID: 19697161) Jacobsson J.A. … Fredriksson R. (J. Mol. Neurosci. 2010) 2 3 67
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PMID: 15203218) Fu G.K. … Stuve L.L. (Genomics 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC18B1 Gene

Sources for SLC18B1 Gene