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SLC18A3 Gene

protein-coding   GIFtS: 59
GCID: GC10P050818

Solute Carrier Family 18 (Vesicular Acetylcholine Transporter),...

  See SLC18A3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 18 (Vesicular Acetylcholine Transporter), Member
31 2
     Solute Carrier Family 18, Member 32
VACHT2 3 5     Vesicular Acetylcholine Transporter2
Solute Carrier Family 18 Member 32 3     VAChT3
Solute Carrier Family 18 (Vesicular Acetylcholine), Member 32     

External Ids:    HGNC: 109361   Entrez Gene: 65722   Ensembl: ENSG000001877147   OMIM: 6003365   UniProtKB: Q165723   

Export aliases for SLC18A3 gene to outside databases

Previous GC identifers: GC10P049723 GC10P050710 GC10P050162 GC10P050488 GC10P045083


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC18A3 Gene:
This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports
acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes
a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline
acetyltransferase gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC18A3 Gene:
SLC18A3 (solute carrier family 18 (vesicular acetylcholine transporter), member 3) is a protein-coding gene. Diseases associated with SLC18A3 include bronchioalveolar carcinoma, and ulnar nerve lesion. GO annotations related to this gene include acetylcholine transmembrane transporter activity. An important paralog of this gene is SLC18B1.

UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572
Function: Involved in acetylcholine transport into synaptic vesicles

summary for SLC18A3 Gene:
Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of
ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is
found in the central and peripheral nervous systems in cholinergic pre-synaptic vesicle membranes of
cholinergic neurons, where it is responsible for maintaining the concentration of acetylcholine (ACh).
Cholinergic synaptic vesicles contain a H+-ATPase, which creates an electrical gradient across the vesicular
membrane. VAChT acts as an ACh-H+ antiporter to facilitate the uptake of ACh. Interestingly, the VAChT gene
is located within the first intron of the choline acetyltransferase gene (ChAT), the enzyme that catalyzes
ACh synthesis from choline and acetyl coenzyme A. This may be to allow co-ordinated regulation of the two
proteins.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC18A3 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC18A3 promoter sequence
   Search Chromatin IP Primers for SLC18A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC18A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.2

SLC18A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC18A3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P050818:  view genomic region     (about GC identifiers)

Start:
50,818,347 bp from pter      End:
50,820,766 bp from pter
Size:
2,420 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572 (See protein sequence)
Recommended Name: Vesicular acetylcholine transporter  
Size: 532 amino acids; 56903 Da
Secondary accessions: B2R7S1

Explore the universe of human proteins at neXtProt for SLC18A3: NX_Q16572

Explore proteomics data for SLC18A3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn89, Asn96
  • Modification sites at PhosphoSitePlus

  • See SLC18A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003046.2  
    ENSEMBL proteins: 
     ENSP00000363229  
    Reactome Protein details: Q16572

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Vesicular acetylcholine transporter
    SLC18 family of vesicular amine transporters

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q16572

    ProtoNet protein and cluster: Q16572

    UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572
    Similarity: Belongs to the major facilitator superfamily. Vesicular transporter family


    Find genes that share domains with SLC18A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VACHT_HUMAN, Q16572
    Function: Involved in acetylcholine transport into synaptic vesicles

         Genatlas biochemistry entry for SLC18A3:
    solute carrier family 18,member A3,vesicular acetyl-choline transporter,embedded in the first intron of CHAT

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005277acetylcholine transmembrane transporter activity TAS8071310
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC18A3           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Slc18a3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     no phenotypic analysis  skeleton 

    Find genes that share phenotypes with SLC18A3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chat/Slc18a3Chat/tm1.1Vpra for SLC18A3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VACHT_HUMAN, Q16572: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8071310
    GO:0016020membrane TAS8071310
    GO:0016021integral component of membrane ----
    GO:0060201clathrin-sculpted acetylcholine transport vesicle membrane TAS--

    Find genes that share ontologies with SLC18A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC18A3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    3Neurotransmitter Release Cycle
    Neurotransmitter Release Cycle0.32
    Acetylcholine Neurotransmitter Release Cycle0.00
    4Circadian entrainment
    Cholinergic synapse0.37
    5Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)
    Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)


    Find genes that share SuperPaths with SLC18A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC18A3
        Synaptic Vesicle Pathway

    1 Reactome Pathway for SLC18A3
        Acetylcholine Neurotransmitter Release Cycle

    1 PharmGKB Pathway for SLC18A3
        Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

    2 Kegg Pathways  (Kegg details for SLC18A3):
        Synaptic vesicle cycle
    Cholinergic synapse

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC18A3
    Interactions:

        GeneGlobe Interaction Network for SLC18A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC18A3 (ENSP000003632294) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHATENSP000003371034STRING: ENSP00000337103
    CPLX1ENSP000003056134STRING: ENSP00000305613
    RAB3AENSP000002222564STRING: ENSP00000222256
    RIMS1ENSP000002648394STRING: ENSP00000264839
    SYT1ENSP000002612054STRING: ENSP00000261205
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0015870acetylcholine transport TAS8071310
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SLC18A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Compounds for SLC18A3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+-)-Vesamicol hydrochlorideInhibits ACh transport[22232-64-0]

    4 IUPHAR Ligands for SLC18A3 (Vesicular acetylcholine transporter)    About this table
    LigandTypeActionAffinityPubmed IDs
    aminobenzovesamicol
    InhibitorInhibition10.97702637
    vesamicol
    InhibitorInhibition8.77702637
    [3H]vesamicol
    NoneNone8.48910293
    [123I]iodobenzovesamicol
    NoneNone8.4--

    Selected Novoseek inferred chemical compound relationships for SLC18A3 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (+-)vesamicol 94.8 47 16095762 (5), 10511440 (3), 18324757 (3), 9375695 (3) (see all 20)
    acetylcholine 88.9 374 10727789 (6), 8910293 (5), 11551909 (5), 14622097 (5) (see all 99)
    choline 79.5 58 16303947 (2), 10421878 (2), 9188041 (1), 12417445 (1) (see all 32)
    d-alanyl-d-alanine 56.7 1 9651318 (1)
    spec-t 32.9 5 18191587 (2), 15653342 (1), 20218624 (1)
    alpha-bungarotoxin 31.4 8 16437206 (4)
    tyrosine 30.2 20 11867570 (1), 18643894 (1), 19151028 (1), 18649990 (1) (see all 13)
    dopamine 28.5 9 11494403 (2), 12629668 (1), 11994133 (1), 11099458 (1)
    retinoic acid 23.6 5 10797533 (2), 12808116 (1), 9298234 (1)
    glutamate 21.4 9 18464935 (1), 16572456 (1), 10769030 (1), 18219665 (1)



    Find genes that share compounds with SLC18A3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC18A3 gene: 
    NM_003055.2  

    Unigene Cluster for SLC18A3:

    Solute carrier family 18 (vesicular acetylcholine), member 3
    Hs.654374  [show with all ESTs]
    Unigene Representative Sequence: NM_003055
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374115(uc001jhw.3)
    miRNA
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    Additional mRNA sequence: 

    AK313094.1 BC007765.2 U09210.1 

    4 DOTS entries:

    DT.106331  DT.100740159  DT.91755636  DT.100722261 

    12 AceView cDNA sequences:

    BX281095 BG117646 AL515585 NM_003055 BC007765 U09210 BF310329 AL526357 
    BM475435 AL526321 AL515584 BF317441 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC18A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTGGCCA
    SLC18A3 Expression
    About this image


    SLC18A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Vomeronasal organ   
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Motor Neurons (Nervous System)
             Retinoic acid- and Sonic hedgehog-induced neural rosettes
     
     Spinal Cord (Nervous System)
             Retinoic acid- and Sonic hedgehog-induced neural rosettes
    SLC18A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC18A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654374

    UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572
    Tissue specificity: Peripheral and central cholinergic nervous systems

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC18A3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc18a31 , 5 solute carrier family 18 (vesicular monoamine), member more1, 5 85.61(n)1
    95.06(a)1
      14 (19.40 cM)5
    205081  NM_021712.21  NP_068358.21 
     324624375 
    chicken
    (Gallus gallus)
    Aves SLC18A31 solute carrier family 18 (vesicular acetylcholine), more 72.86(n)
    71.11(a)
      404302  NM_206982.1  NP_996865.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC18A36
    solute carrier family 18 (vesicular acetylcholine ...
    71(a)
    1 ↔ 1
    GL343199.1(3477625-3479199)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc18a31 solute carrier family 18 (vesicular acetylcholine transporter), more 63.19(n)
    70.48(a)
      780320  NM_001079391.1  NP_001072859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc18a3b1 solute carrier family 18 (vesicular acetylcholine), more 74.65(n)
    76.26(a)
      394082  NM_201107.1  NP_957401.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta VAChT1 , 3 neurotransmitter transport
    acetylcholine transporter3
    VAChT1
    52(a)3
    60.22(n)1
    55.7(a)1
      91C33
    427951  NM_057790.41  NP_477138.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-171 , 3 putative acetylcholine transporter3
    unc-171
    50(a)3
    54.12(n)1
    53.06(a)1
      IV(3618500-3623471)3
    131926841  NM_001028431.31  NP_001023602.11 


    ENSEMBL Gene Tree for SLC18A3 (if available)
    TreeFam Gene Tree for SLC18A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC18A3 gene
    SLC18B12  SLC18A12  SLC18A22  
    2 SIMAP similar genes for SLC18A3 using alignment to 1 protein entry:     VACHT_HUMAN:
    SLC18A2    SLC18A1

    Find genes that share paralogs with SLC18A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for SLC18A3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81877301,2,4
    ----see VAR_0246382 mis40--------
    rs81877341,2,4
    ----see VAR_0200352 mis40--------
    rs81877321,2,4
    ----see VAR_0291522 mis40--------
    rs81877331,2,4
    ----see VAR_0200342 mis40--------

    HapMap Linkage Disequilibrium report for SLC18A3 (50818347 - 50820766 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC18A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895365CNV Loss21882294
    nsv895369CNV Gain21882294
    nsv895375CNV Gain21882294
    nsv895378CNV Gain21882294
    nsv7203OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC18A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC18A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600336    OMIM disorders: --

    6 diseases for SLC18A3:    
    About MalaCards
    bronchioalveolar carcinoma    ulnar nerve lesion    tendinosis    pheochromocytoma
    amyotrophic lateral sclerosis    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for SLC18A3:
    Ulnar nerve lesion     Alzheimer's disease

    Find genes that share disorders with SLC18A3           About GenesLikeMe

    4 Novoseek inferred disease relationships for SLC18A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 34.9 8 10421878 (2), 9330972 (1), 16516472 (1), 18191587 (1) (see all 5)
    pheochromocytoma 14.4 6 8910293 (1), 9782458 (1), 8071310 (1)
    amyotrophic lateral sclerosis 2.3 2 9600225 (1)
    neurodegenerative diseases 0 1 18506194 (1)

    Genetic Association Database (GAD): SLC18A3
    Human Genome Epidemiology (HuGE) Navigator: SLC18A3 (4 documents)

    Export disorders for SLC18A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC18A3 gene, integrated from 10 sources (see all 168):
    (articles sorted by number of sources associating them with SLC18A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional identification of a vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus. (PubMed id 8071310)1, 2, 3, 9 Erickson J.D.... Usdin T.B. (J. Biol. Chem. 1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    4. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. (PubMed id 12759818)1, 4 Harold D....Jones L. (Hum. Genet. 2003)
    7. Multiple protonation states of vesicular acetylcholine transporter detected by binding of [3H]vesamicol. (PubMed id 19685929)1, 9 Khare P....Parsons S.M. (Biochemistry 2009)
    8. Active transport of acetylcholine by the human vesicular acetylcholine transporter. (PubMed id 8910293)1, 9 Varoqui H. and Erickson J.D. (J. Biol. Chem. 1996)
    9. Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporter. (PubMed id 8860234)1, 9 Schafer M.K....Eiden L.E. (J. Mol. Neurosci. 1995)
    10. Somatomotor neuron-specific expression of the human cholinergic gene locus in transgenic mice. (PubMed id 10727789)1, 9 SchA1tz B....Eiden L.E. (Neuroscience 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6572 HGNC: 10936 AceView: SLC18A3 Ensembl:ENSG00000187714 euGenes: HUgn6572
    ECgene: SLC18A3 Kegg: 6572 H-InvDB: SLC18A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC18A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC18A3 gene:
    Search GeneIP for patents involving SLC18A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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