Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC18A3 Gene

Aliases for SLC18A3 Gene

  • Solute Carrier Family 18 Member A3 2 3 5
  • Solute Carrier Family 18 (Vesicular Acetylcholine Transporter), Member 3 2 3
  • VACHT 3 4
  • Solute Carrier Family 18 (Vesicular Acetylcholine), Member 3 3
  • Vesicular Acetylcholine Transporter 3
  • Solute Carrier Family 18, Member 3 3
  • Solute Carrier Family 18 Member 3 4
  • CMS21 3

External Ids for SLC18A3 Gene

Previous GeneCards Identifiers for SLC18A3 Gene

  • GC10P049723
  • GC10P050710
  • GC10P050162
  • GC10P050488
  • GC10P050818
  • GC10P045083

Summaries for SLC18A3 Gene

Entrez Gene Summary for SLC18A3 Gene

  • This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC18A3 Gene

SLC18A3 (Solute Carrier Family 18 Member A3) is a Protein Coding gene. Diseases associated with SLC18A3 include Ulnar Nerve Lesion and Tendinosis. Among its related pathways are Transmission across Chemical Synapses and Vesicle-mediated transport. GO annotations related to this gene include transmembrane transporter activity and acetylcholine transmembrane transporter activity. An important paralog of this gene is SLC18A1.

UniProtKB/Swiss-Prot for SLC18A3 Gene

  • Involved in acetylcholine transport into synaptic vesicles.

Tocris Summary for SLC18A3 Gene

  • Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is found in the central and peripheral nervous systems.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC18A3 Gene

Genomics for SLC18A3 Gene

Regulatory Elements for SLC18A3 Gene

Enhancers for SLC18A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F049649 0.7 Ensembl 12 +39.3 39293 0.4 FOXP2 PRDM10 YY1 SLC18A3 CHAT AGAP6 C10orf53
GH10F049652 0.6 ENCODE 11.3 +42.6 42562 1.3 EGR2 CHAT SLC18A3 AGAP6 C10orf53
GH10F049690 0.2 ENCODE 10.3 +80.1 80069 0.2 BCL11A CBX2 POU5F1 KDM1A OGDHL MAPK6PS6 CHAT SLC18A3 C10orf53 GC10M049685
GH10F049689 0.2 ENCODE 10.3 +79.8 79769 0.2 KDM1A OGDHL MAPK6PS6 SLC18A3 CHAT C10orf53 GC10M049685
GH10F049567 1.3 FANTOM5 Ensembl ENCODE 8.9 -41.4 -41396 2.2 TBP MXI1 TAF1 JUN MAX RELA RFX5 CBX5 NFYB RCOR1 ERCC6 SLC18A3 CHAT PGBD3 HMGB1P50 GC10P049595
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC18A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC18A3 Gene

49,610,301 bp from pter
49,612,720 bp from pter
2,420 bases
Plus strand

Genomic View for SLC18A3 Gene

Genes around SLC18A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC18A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC18A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC18A3 Gene

Proteins for SLC18A3 Gene

  • Protein details for SLC18A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicular acetylcholine transporter
    Protein Accession:
    Secondary Accessions:
    • B2R7S1

    Protein attributes for SLC18A3 Gene

    532 amino acids
    Molecular mass:
    56903 Da
    Quaternary structure:
    • Interacts with SEC14L1.

neXtProt entry for SLC18A3 Gene

Post-translational modifications for SLC18A3 Gene

  • Glycosylation at Asn 89 and Asn 96
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC18A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC18A3 Gene

Domains & Families for SLC18A3 Gene

Gene Families for SLC18A3 Gene

Protein Domains for SLC18A3 Gene


Suggested Antigen Peptide Sequences for SLC18A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Vesicular transporter family.
  • Belongs to the major facilitator superfamily. Vesicular transporter family.
genes like me logo Genes that share domains with SLC18A3: view

Function for SLC18A3 Gene

Molecular function for SLC18A3 Gene

GENATLAS Biochemistry:
solute carrier family 18,member A3,vesicular acetyl-choline transporter,embedded in the first intron of CHAT
UniProtKB/Swiss-Prot Function:
Involved in acetylcholine transport into synaptic vesicles.

Gene Ontology (GO) - Molecular Function for SLC18A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005277 acetylcholine transmembrane transporter activity TAS --
GO:0008504 monoamine transmembrane transporter activity IBA --
GO:0042166 acetylcholine binding IBA --
genes like me logo Genes that share ontologies with SLC18A3: view
genes like me logo Genes that share phenotypes with SLC18A3: view

Animal Models for SLC18A3 Gene

MGI Knock Outs for SLC18A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC18A3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC18A3 Gene

Localization for SLC18A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC18A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC18A3 Gene COMPARTMENTS Subcellular localization image for SLC18A3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC18A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8071310
GO:0016020 membrane TAS 8071310
GO:0016021 integral component of membrane IEA --
GO:0030121 AP-1 adaptor complex IBA --
genes like me logo Genes that share ontologies with SLC18A3: view

Pathways & Interactions for SLC18A3 Gene

genes like me logo Genes that share pathways with SLC18A3: view

Interacting Proteins for SLC18A3 Gene

Gene Ontology (GO) - Biological Process for SLC18A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport IEA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007269 neurotransmitter secretion TAS --
GO:0015844 monoamine transport IEA --
genes like me logo Genes that share ontologies with SLC18A3: view

No data available for SIGNOR curated interactions for SLC18A3 Gene

Drugs & Compounds for SLC18A3 Gene

(17) Drugs for SLC18A3 Gene - From: ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rocuronium Approved Pharma TGF-βR I kinase inhibitor, Neuromuscular blocker for anaesthesia;aminosteroid 261
[<sup>123</sup>I]iodobenzovesamicol Pharma 0
[<sup>3</sup>H]vesamicol Pharma 0
aminobenzovesamicol Pharma Inhibition, Inhibitor 0
vesamicol Pharma Inhibition, Inhibitor 0

(13) Additional Compounds for SLC18A3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Vesamicol hydrochloride
ML 352 hydrochloride

(2) Tocris Compounds for SLC18A3 Gene

Compound Action Cas Number
(+-)-Vesamicol hydrochloride Inhibits ACh transport 120447-62-3
ML 352 hydrochloride High affinity and selective presynaptic choline transporter (CHT) inhibitor

(1) ApexBio Compounds for SLC18A3 Gene

Compound Action Cas Number
Rocuronium Neuromuscular blocker for anaesthesia;aminosteroid 143558-00-3
genes like me logo Genes that share compounds with SLC18A3: view

Transcripts for SLC18A3 Gene

mRNA/cDNA for SLC18A3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC18A3 Gene

Solute carrier family 18 (vesicular acetylcholine), member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC18A3 Gene

No ASD Table

Relevant External Links for SLC18A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC18A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC18A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC18A3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x14.2), Brain - Caudate (basal ganglia) (x8.6), and Brain - Hypothalamus (x4.9).

Protein differential expression in normal tissues from HIPED for SLC18A3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC18A3 Gene

Protein tissue co-expression partners for SLC18A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC18A3 Gene:


SOURCE GeneReport for Unigene cluster for SLC18A3 Gene:


mRNA Expression by UniProt/SwissProt for SLC18A3 Gene:

Tissue specificity: Peripheral and central cholinergic nervous systems.
genes like me logo Genes that share expression patterns with SLC18A3: view

Primer Products

Orthologs for SLC18A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC18A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC18A3 34 35
  • 99 (n)
(Rattus norvegicus)
Mammalia Slc18a3 34
  • 85.8 (n)
(Mus musculus)
Mammalia Slc18a3 34 16
  • 85.61 (n)
(Canis familiaris)
Mammalia SLC18A3 34 35
  • 85.55 (n)
(Bos Taurus)
Mammalia SLC18A3 34 35
  • 84.61 (n)
(Monodelphis domestica)
Mammalia SLC18A3 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SLC18A3 35
  • 74 (a)
(Gallus gallus)
Aves SLC18A3 34
  • 72.86 (n)
(Anolis carolinensis)
Reptilia SLC18A3 35
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc18a3 34
  • 63.19 (n)
(Danio rerio)
Actinopterygii slc18a3b 34
  • 74.65 (n)
CABZ01112647.1 35
  • 69 (a)
slc18a3a 35
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002369 34
  • 61.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta VAChT 36 34 35
  • 60.22 (n)
(Caenorhabditis elegans)
Secernentea unc-17 36 34 35
  • 54.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 8 (a)
Species where no ortholog for SLC18A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC18A3 Gene

Gene Tree for SLC18A3 (if available)
Gene Tree for SLC18A3 (if available)

Paralogs for SLC18A3 Gene

Paralogs for SLC18A3 Gene

(2) SIMAP similar genes for SLC18A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC18A3: view

Variants for SLC18A3 Gene

Sequence variations from dbSNP and Humsavar for SLC18A3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs112117098 -- 49,610,234(+) GGGCA(A/C)CACTC intron-variant, upstream-variant-2KB
rs112650831 -- 49,610,115(+) GAGCC(C/T)TTCCT intron-variant, upstream-variant-2KB
rs112798036 -- 49,612,403(+) AGCCC(A/G)CTGGC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs113382527 -- 49,612,591(+) CTGAG(A/T)CCCCA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs113595173 -- 49,610,694(+) CCAGC(G/T)CTCGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC18A3 Gene

Variant ID Type Subtype PubMed ID
nsv1042677 CNV loss 25217958
nsv550819 CNV loss 21841781
nsv950954 CNV deletion 24416366

Variation tolerance for SLC18A3 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC18A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC18A3 Gene

Disorders for SLC18A3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC18A3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ulnar nerve lesion
  • lesion of ulnar nerve
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC18A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC18A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC18A3 Gene

Publications for SLC18A3 Gene

  1. Functional identification of a vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus. (PMID: 8071310) Erickson J.D. … Usdin T.B. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
  4. Multiple protonation states of vesicular acetylcholine transporter detected by binding of [3H]vesamicol. (PMID: 19685929) Khare P. … Parsons S.M. (Biochemistry 2009) 3 22 64
  5. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan A.R. … Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 46 64

Products for SLC18A3 Gene

Sources for SLC18A3 Gene

Loading form....