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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC18A3 Gene

protein-coding   GIFtS: 57
GCID: GC10P050818

solute carrier family 18 (vesicular acetylcholine), member...
 Explore 28 diseases affiliated with
SLC18A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC18A3    

Aliases
for SLC18A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 18 (Vesicular Acetylcholine), Member 31 2
VACHT1 2 3 5
Solute Carrier Family 18 Member 32 3
Solute Carrier Family 18, Member 32
Vesicular Acetylcholine Transporter2
VAChT3

External Ids:    HGNC: 109361   Entrez Gene: 65722   Ensembl: ENSG000001877147   OMIM: 6003365   UniProtKB: Q165723   

Export aliases for SLC18A3 gene to outside databases

Previous GC identifers: GC10P049723 GC10P050710 GC10P050162 GC10P050488 GC10P045083


Summaries
for SLC18A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC18A3:
This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports
acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a
proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline
acetyltransferase gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572
Function: Involved in acetylcholine transport into synaptic vesicles

summary for SLC18A3:
Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of
ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is
found in the central and peripheral nervous systems in cholinergic pre-synaptic vesicle membranes of
cholinergic neurons, where it is responsible for maintaining the concentration of acetylcholine (ACh).
Cholinergic synaptic vesicles contain a H+-ATPase, which creates an electrical gradient across the vesicular
membrane. VAChT acts as an ACh-H+ antiporter to facilitate the uptake of ACh. Interestingly, the VAChT gene
is located within the first intron of the choline acetyltransferase gene (ChAT), the enzyme that catalyzes
ACh synthesis from choline and acetyl coenzyme A. This may be to allow co-ordinated regulation of the two
proteins.




Genomic Views
for SLC18A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC18A3 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC18A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC18A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC18A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.2

SLC18A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC18A3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P050818:  view genomic region     (about GC identifiers)

Start:
 50,818,347 bp from pter      End:
 50,820,766 bp from pter
Size:
 2,420 bases      Orientation:
 plus strand

Proteins
for SLC18A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572 (See protein sequence)
Recommended Name: Vesicular acetylcholine transporter  
Size: 532 amino acids; 56903 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R7S1

Explore the universe of human proteins at neXtProt for SLC18A3: NX_Q16572

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16572

    • SLC18A3 Protein expression data from MOPED and PaxDb:    About this image 
    SLC18A3 Protein Expression
    REFSEQ proteins: NP_003046.2  
    ENSEMBL proteins: 
     ENSP00000363229  
    Reactome Protein details: Q16572
    Human Recombinant Protein Products for SLC18A3: 
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    OriGene Protein Over-expression Lysate: SLC18A3
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    Novus Biologicals SLC18A3 Protein
    Novus Biologicals SLC18A3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC18A3

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8071310
    GO:0008021synaptic vesicle ----
    GO:0016020membrane TAS8071310

    SLC18A3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC18A3

    Protein Domains /
    Families
    for SLC18A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC18A3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q16572

    ProtoNet protein and cluster: Q16572

    UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572
    Similarity: Belongs to the major facilitator superfamily. Vesicular transporter family


    Function
    for SLC18A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VACHT_HUMAN, Q16572
    Function: Involved in acetylcholine transport into synaptic vesicles

         Genatlas biochemistry entry for SLC18A3:
    solute carrier family 18,member A3,vesicular acetyl-choline transporter,embedded in the first intron of CHAT

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005277acetylcholine transmembrane transporter activity TAS8071310
    GO:0042166acetylcholine binding ----
         
    SLC18A3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Slc18a3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     no phenotypic analysis  skeleton 

    SLC18A3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Chat/Slc18a3Chat/tm1.1Vpra for SLC18A3
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC18A3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC18A3
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC18A3:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-1271 hsa-miR-765 hsa-miR-96 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: SLC18A3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC18A3 (see all 7)
    OriGene shRNA RFP: SLC18A3
    OriGene siRNA: SLC18A3
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC18A3 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SLC18A3 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18A3


    Pathways & Interactions
    for SLC18A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    2Sympathetic Nerve Pathway (Neuroeffector Junction)
    		Sympathetic Nerve Pathway (Neuroeffector Junction)1.00
    3Selected targets of GCR-alpha
    		Selected targets of GCR-alpha1.00
    4Selected targets of CREB1
    		Selected targets of CREB11.00
    5Synaptic Vesicle Pathway
    		Synaptic Vesicle Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for SLC18A3
        Selected targets of CREB1
    Selected targets of GCR-alpha


    1 BioSystems Pathway for SLC18A3 
        Synaptic Vesicle Pathway

    4        Reactome Pathways for SLC18A3
        Acetylcholine Neurotransmitter Release Cycle
    Transmission across Chemical Synapses
    Neurotransmitter Release Cycle
    Neuronal System

    2 PharmGKB Pathways for SLC18A3
        Sympathetic Nerve Pathway (Neuroeffector Junction)
    Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

    1         Kegg Pathway  (Kegg details for SLC18A3):
        Cholinergic synapse


    SLC18A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC18A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for SLC18A3 (ENSP000003632294) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHATENSP000003371034STRING: ENSP00000337103
    CPLX1ENSP000003056134STRING: ENSP00000305613
    RAB3AENSP000002222564STRING: ENSP00000222256
    RIMS1ENSP000002648394STRING: ENSP00000264839
    SYT1ENSP000002612054STRING: ENSP00000261205
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0015870acetylcholine transport TAS8071310

    SLC18A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC18A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC18A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLC18A3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (±)-Vesamicol hydrochlorideInhibits ACh transport[22232-64-0]
    10/23 Novoseek chemical compound relationships for SLC18A3 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (+-)vesamicol 94.8 47 16095762 (5), 10511440 (3), 18324757 (3), 9375695 (3) (see all 20)
    acetylcholine 88.9 374 10727789 (6), 8910293 (5), 11551909 (5), 14622097 (5) (see all 99)
    choline 79.5 58 16303947 (2), 10421878 (2), 9188041 (1), 12417445 (1) (see all 32)
    d-alanyl-d-alanine 56.7 1 9651318 (1)
    spec-t 32.9 5 18191587 (2), 15653342 (1), 20218624 (1)
    alpha-bungarotoxin 31.4 8 16437206 (4)
    tyrosine 30.2 20 11867570 (1), 18643894 (1), 19151028 (1), 18649990 (1) (see all 13)
    dopamine 28.5 9 11494403 (2), 12629668 (1), 11994133 (1), 11099458 (1)
    retinoic acid 23.6 5 10797533 (2), 12808116 (1), 9298234 (1)
    glutamate 21.4 9 18464935 (1), 16572456 (1), 10769030 (1), 18219665 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC18A3 / VACHT 

    Transcripts
    for SLC18A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC18A3 gene: 
    NM_003055.2  

    Unigene Cluster for SLC18A3:

    Solute carrier family 18 (vesicular acetylcholine), member 3
    Hs.654374  [show with all ESTs]
    Unigene Representative Sequence: NM_003055
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374115(uc001jhw.3)

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    hsa-miR-125a-5p hsa-miR-125b hsa-miR-1271 hsa-miR-765 hsa-miR-96 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: SLC18A3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK313094.1 BC007765.2 U09210.1 

    4 DOTS entries:

    DT.106331  DT.100740159  DT.91755636  DT.100722261 

    12 AceView cDNA sequences:

    BX281095 BC007765 AL526357 BG117646 NM_003055 AL515585 U09210 BF310329 
    AL515584 AL526321 BM475435 BF317441 

    GeneLoc Exon Structure


    Expression
    for SLC18A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC18A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGACTGGCCA
    SLC18A3 Expression
    About this image

    SLC18A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerCholinergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC18A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC18A3

    SOURCE GeneReport for Unigene cluster: Hs.654374

    UniProtKB/Swiss-Prot: VACHT_HUMAN, Q16572
    Tissue specificity: Peripheral and central cholinergic nervous systems

        SABiosciences Custom PCR Arrays for SLC18A3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18A3

    Orthologs
    for SLC18A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC18A3 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC18A31 solute carrier family 18 (vesicular acetylcholine), more 73.49(n)
    72.44(a)    		   404302  NM_206982.1  NP_996865.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC18A36
    		 --
    		 70(a)
    		 1 ↔ 1
    		 GL343199.1(3477625-3479199)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc18a3b1 solute carrier family 18 (vesicular acetylcholine), more 74.65(n)
    76.26(a)    		   394082  NM_201107.1  NP_957401.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta VAChT1 , 3 neurotransmitter transport acetylcholine
    transporter3
    CG32848-PA1    		 52(a)3
    60.22(n)1
    55.7(a)1    		   91C33
    427951  NM_057790.41  NP_477138.11 


    ENSEMBL Gene Tree for SLC18A3 (if available)
    TreeFam Gene Tree for SLC18A3 (if available) 

    Paralogs
    for SLC18A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC18A3 gene
    SLC18B12  SLC18A22  SLC18A12  
    2 SIMAP similar genes for SLC18A3 using alignment to 1 protein entry:     VACHT_HUMAN:
    SLC18A2    SLC18A1

    SLC18A3 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC18A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SLC18A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC18A3 for disorders           About GeneDecksing

    OMIM gene information: 600336    OMIM disorders: --

    20/28 diseases for SLC18A3 (see all 28):    About MalaCards
    spinal cord injury    amyotrophic lateral sclerosis    duchenne muscular dystrophy    status epilepticus
    lateral sclerosis    infectious mononucleosis    muscular dystrophy    allergic rhinitis
    myotonic dystrophy    chronic pain    neurodegenerative disease    ulcerative colitis
    rhinitis    pheochromocytoma    chagas disease    alzheimer's disease
    albinism    down syndrome    huntington's disease    parkinson's disease

    2 diseases from the University of Copenhagen DISEASES database for SLC18A3:
    Alzheimer's disease     Ulnar nerve lesion

    4 Novoseek disease relationships for SLC18A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 34.9 8 10421878 (2), 9330972 (1), 16516472 (1), 18191587 (1) (see all 5)
    pheochromocytoma 14.4 6 8910293 (1), 9782458 (1), 8071310 (1)
    amyotrophic lateral sclerosis 2.3 2 9600225 (1)
    neurodegenerative diseases 0 1 18506194 (1)

    Genetic Association Database (GAD): SLC18A3
    Human Genome Epidemiology (HuGE) Navigator: SLC18A3 (4 documents)

    Export disorders for SLC18A3 gene to outside databases

    Publications
    for SLC18A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC18A3 gene, integrated from 9 sources (see all 166):
    (articles sorted by number of sources associating them with SLC18A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional identification of a vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus. (PubMed id 8071310)1, 2, 3, 9 Erickson J.D.... Usdin T.B. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. (PubMed id 12759818)1, 4 Harold D....Jones L. (2003)
    4. Multiple protonation states of vesicular acetylcholin e transporter detected by binding of [3H]vesamicol. (PubMed id 19685929)1, 9 Khare P....Parsons S.M. (2009)
    5. Active transport of acetylcholine by the human vesicular acetylcholine transporter. (PubMed id 8910293)1, 9 Varoqui H. and Erickson J.D. (1996)
    6. Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporter. (PubMed id 8860234)1, 9 Schafer M.K....Eiden L.E. (1995)
    7. Somatomotor neuron-specific expression of the human cholinergic gene locus in transgenic mice. (PubMed id 10727789)1, 9 Schutz B....Eiden L.E. (2000)
    8. Identification of a region from the human cholinergic gene locus that targets expression of the vesicular acetylcholine transporter to a subset of neurons in the medial habenular nucleus in transgenic mice. (PubMed id 14622097)1, 9 Schutz B....Eiden L.E. (2003)
    9. The vesicular acetylcholine transporter is present in melanocytes and keratinocytes in the human epidermis. (PubMed id 16763548)1, 9 Elwary S.M....Schallreuter K.U. (2006)
    10. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. (PubMed id 12417445)1, 9 Tayebati S.K....Amenta F. (2002)

    External Searches for SLC18A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SLC18A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6572 HGNC: 10936 AceView: SLC18A3 Ensembl:ENSG00000187714 euGenes: HUgn6572
    ECgene: SLC18A3 Kegg: 6572 H-InvDB: SLC18A3

    Other Databases showing SLC18A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC18A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC18A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC18A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC18A3 gene:
    Search GeneIP for patents involving SLC18A3

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