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Aliases for SLC18A3 Gene

Aliases for SLC18A3 Gene

  • Solute Carrier Family 18 (Vesicular Acetylcholine Transporter), Member 3 2 3
  • VACHT 3 4 6
  • Solute Carrier Family 18 Member 3 3 4
  • Solute Carrier Family 18 (Vesicular Acetylcholine), Member 3 3
  • Vesicular Acetylcholine Transporter 3
  • Solute Carrier Family 18, Member 3 3

External Ids for SLC18A3 Gene

Summaries for SLC18A3 Gene

Entrez Gene Summary for SLC18A3 Gene

  • This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC18A3 Gene

SLC18A3 (Solute Carrier Family 18 (Vesicular Acetylcholine Transporter), Member 3) is a Protein Coding gene. Diseases associated with SLC18A3 include ulnar nerve lesion and pheochromocytoma. Among its related pathways are Transmission across Chemical Synapses and Transmission across Chemical Synapses. GO annotations related to this gene include acetylcholine transmembrane transporter activity. An important paralog of this gene is SLC18A2.

UniProtKB/Swiss-Prot for SLC18A3 Gene

  • Involved in acetylcholine transport into synaptic vesicles.

Tocris Summary for SLC18A3 Gene

  • Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is found in the central and peripheral nervous systems in cholinergic pre-synaptic vesicle membranes of cholinergic neurons, where it is responsible for maintaining the concentration of acetylcholine (ACh). Cholinergic synaptic vesicles contain a H+-ATPase, which creates an electrical gradient across the vesicular membrane. VAChT acts as an ACh-H+ antiporter to facilitate the uptake of ACh. Interestingly, the VAChT gene is located within the first intron of the choline acetyltransferase gene (ChAT), the enzyme that catalyzes ACh synthesis from choline and acetyl coenzyme A. This may be to allow co-ordinated regulation of the two proteins.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC18A3 Gene

Genomics for SLC18A3 Gene

Genomic Location for SLC18A3 Gene

Start:
49,610,301 bp from pter
End:
49,612,720 bp from pter
Size:
2,420 bases
Orientation:
Plus strand

Genomic View for SLC18A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC18A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC18A3 Gene

Regulatory Elements for SLC18A3 Gene

Proteins for SLC18A3 Gene

  • Protein details for SLC18A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16572-VACHT_HUMAN
    Recommended name:
    Vesicular acetylcholine transporter
    Protein Accession:
    Q16572
    Secondary Accessions:
    • B2R7S1

    Protein attributes for SLC18A3 Gene

    Size:
    532 amino acids
    Molecular mass:
    56903 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC18A3 Gene

Proteomics data for SLC18A3 Gene at MOPED

Post-translational modifications for SLC18A3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn89 and Asn96

Other Protein References for SLC18A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC18A3 Gene

Domains for SLC18A3 Gene

Gene Families for SLC18A3 Gene

Protein Domains for SLC18A3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

VACHT_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Vesicular transporter family.:
    • Q16572
genes like me logo Genes that share domains with SLC18A3: view

Function for SLC18A3 Gene

Molecular function for SLC18A3 Gene

GENATLAS Biochemistry: solute carrier family 18,member A3,vesicular acetyl-choline transporter,embedded in the first intron of CHAT
UniProtKB/Swiss-Prot Function: Involved in acetylcholine transport into synaptic vesicles.

Gene Ontology (GO) - Molecular Function for SLC18A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005277 acetylcholine transmembrane transporter activity TAS 8071310
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC18A3: view
genes like me logo Genes that share phenotypes with SLC18A3: view

Animal Models for SLC18A3 Gene

MGI Knock Outs for SLC18A3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC18A3 Gene

Localization for SLC18A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC18A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC18A3 Gene COMPARTMENTS Subcellular localization image for SLC18A3 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLC18A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8071310
GO:0016020 membrane TAS 8071310
GO:0016021 integral component of membrane --
GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane TAS --
genes like me logo Genes that share ontologies with SLC18A3: view

Pathways for SLC18A3 Gene

genes like me logo Genes that share pathways with SLC18A3: view

Pathways by source for SLC18A3 Gene

Interacting Proteins for SLC18A3 Gene

Gene Ontology (GO) - Biological Process for SLC18A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0015870 acetylcholine transport TAS 8071310
GO:0055085 transmembrane transport --
GO:0072488 ammonium transmembrane transport TAS 8071310
genes like me logo Genes that share ontologies with SLC18A3: view

Compounds for SLC18A3 Gene

(1) Tocris Compounds for SLC18A3 Gene

Compound Action Cas Number
(+-)-Vesamicol hydrochloride Inhibits ACh transport [22232-64-0]

(4) IUPHAR Ligand for SLC18A3 Gene

Ligand Type Action Affinity Pubmed IDs
aminobenzovesamicol Inhibitor Inhibition 10.9
vesamicol Inhibitor Inhibition 8.7
[3H]vesamicol None None 8.4
[123I]iodobenzovesamicol None None

(23) Novoseek inferred chemical compound relationships for SLC18A3 Gene

Compound -log(P) Hits PubMed IDs
(+-)vesamicol 94.8 33
acetylcholine 88.9 174
choline 79.5 34
d-alanyl-d-alanine 56.7 1
spec-t 32.9 4
genes like me logo Genes that share compounds with SLC18A3: view

Transcripts for SLC18A3 Gene

mRNA/cDNA for SLC18A3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC18A3 Gene

Solute carrier family 18 (vesicular acetylcholine), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC18A3 Gene

No ASD Table

Relevant External Links for SLC18A3 Gene

GeneLoc Exon Structure for
SLC18A3
ECgene alternative splicing isoforms for
SLC18A3

Expression for SLC18A3 Gene

mRNA expression in normal human tissues for SLC18A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC18A3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (14.2), Brain - Caudate (basal ganglia) (8.6), and Brain - Hypothalamus (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC18A3 Gene

SOURCE GeneReport for Unigene cluster for SLC18A3 Gene Hs.654374

mRNA Expression by UniProt/SwissProt for SLC18A3 Gene

Q16572-VACHT_HUMAN
Tissue specificity: Peripheral and central cholinergic nervous systems.
genes like me logo Genes that share expressions with SLC18A3: view

Orthologs for SLC18A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC18A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC18A3 36
  • 99 (n)
  • 98.87 (a)
SLC18A3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC18A3 36
  • 84.61 (n)
  • 87.79 (a)
SLC18A3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC18A3 36
  • 85.55 (n)
  • 90.23 (a)
SLC18A3 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc18a3 36
  • 85.61 (n)
  • 95.06 (a)
Slc18a3 16
oppossum
(Monodelphis domestica)
Mammalia SLC18A3 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC18A3 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc18a3 36
  • 85.8 (n)
  • 95.44 (a)
chicken
(Gallus gallus)
Aves SLC18A3 36
  • 72.86 (n)
  • 71.11 (a)
lizard
(Anolis carolinensis)
Reptilia SLC18A3 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc18a3 36
  • 63.19 (n)
  • 70.48 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01112647.1 37
  • 69 (a)
OneToMany
slc18a3a 37
  • 68 (a)
OneToMany
slc18a3b 36
  • 74.65 (n)
  • 76.26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002369 36
  • 61.95 (n)
  • 53.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta VAChT 36
  • 60.22 (n)
  • 55.7 (a)
VAChT 37
  • 44 (a)
OneToOne
VAChT 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-17 36
  • 54.12 (n)
  • 53.06 (a)
unc-17 37
  • 45 (a)
OneToOne
unc-17 38
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 8 (a)
ManyToMany
Species with no ortholog for SLC18A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC18A3 Gene

ENSEMBL:
Gene Tree for SLC18A3 (if available)
TreeFam:
Gene Tree for SLC18A3 (if available)

Paralogs for SLC18A3 Gene

Paralogs for SLC18A3 Gene

Selected SIMAP similar genes for SLC18A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC18A3: view

Variants for SLC18A3 Gene

Sequence variations from dbSNP and Humsavar for SLC18A3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_020034 -
VAR_020035 -
VAR_024638 -
VAR_029152 -

Structural Variations from Database of Genomic Variants (DGV) for SLC18A3 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895375 CNV Gain 21882294
nsv895378 CNV Gain 21882294

Relevant External Links for SLC18A3 Gene

HapMap Linkage Disequilibrium report
SLC18A3

Disorders for SLC18A3 Gene

(2) University of Copenhagen DISEASES for SLC18A3 Gene

(4) Novoseek inferred disease relationships for SLC18A3 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 34.9 6
pheochromocytoma 14.4 3
amyotrophic lateral sclerosis 2.3 1
neurodegenerative diseases 0 1

Relevant External Links for SLC18A3

Genetic Association Database (GAD)
SLC18A3
Human Genome Epidemiology (HuGE) Navigator
SLC18A3
genes like me logo Genes that share disorders with SLC18A3: view

No data available for UniProtKB/Swiss-Prot for SLC18A3 Gene

Publications for SLC18A3 Gene

  1. Functional identification of a vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus. (PMID: 8071310) Erickson J.D. … Usdin T.B. (J. Biol. Chem. 1994) 2 3 4 23
  2. Somatomotor neuron-specific expression of the human cholinergic gene locus in transgenic mice. (PMID: 10727789) SchA1tz B. … Eiden L.E. (Neuroscience 2000) 3 23
  3. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. (PMID: 12417445) Tayebati S.K. … Amenta F. (J. Neuroimmunol. 2002) 3 23
  4. Expression of the cholinergic gene locus in pulmonary arterial endothelial cells. (PMID: 10883397) Haberberger R.V. … Kummer W. (Histochem. Cell Biol. 2000) 3 23
  5. Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporter. (PMID: 8860234) Schafer M.K. … Eiden L.E. (J. Mol. Neurosci. 1995) 3 23

Products for SLC18A3 Gene

Sources for SLC18A3 Gene

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