Aliases for SLC18A3 Gene
- Solute Carrier Family 18 Member A3 2 3 5
- Solute Carrier Family 18 (Vesicular Acetylcholine Transporter), Member 3 2 3
- VACHT 3 4
- Solute Carrier Family 18 (Vesicular Acetylcholine), Member 3 3
- Vesicular Acetylcholine Transporter 3
- Solute Carrier Family 18, Member 3 3
- Solute Carrier Family 18 Member 3 4
- CMS21 3
External Ids for SLC18A3 Gene
Previous GeneCards Identifiers for SLC18A3 Gene
This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC18A3 Gene
SLC18A3 (Solute Carrier Family 18 Member A3) is a Protein Coding gene. Diseases associated with SLC18A3 include Congenital Myasthenic Syndrome 21 and Presynaptic Congenital Myasthenic Syndromes. Among its related pathways are Neurotransmitter Release Cycle and Vesicle-mediated transport. GO annotations related to this gene include transmembrane transporter activity and acetylcholine transmembrane transporter activity. An important paralog of this gene is SLC18A1.
UniProtKB/Swiss-Prot for SLC18A3 Gene
Involved in acetylcholine transport into synaptic vesicles.
Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is found in the central and peripheral nervous systems.