Aliases for SLC18A3 Gene
External Ids for SLC18A3 Gene
Previous GeneCards Identifiers for SLC18A3 Gene
This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC18A3 Gene
SLC18A3 (Solute Carrier Family 18 (Vesicular Acetylcholine Transporter), Member 3) is a Protein Coding gene. Diseases associated with SLC18A3 include ulnar nerve lesion and tendinosis. Among its related pathways are Transmission across Chemical Synapses and Transmission across Chemical Synapses. GO annotations related to this gene include acetylcholine transmembrane transporter activity. An important paralog of this gene is SLC18A2.
UniProtKB/Swiss-Prot for SLC18A3 Gene
Involved in acetylcholine transport into synaptic vesicles.
Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is found in the central and peripheral nervous systems in cholinergic pre-synaptic vesicle membranes of cholinergic neurons, where it is responsible for maintaining the concentration of acetylcholine (ACh). Cholinergic synaptic vesicles contain a H+-ATPase, which creates an electrical gradient across the vesicular membrane. VAChT acts as an ACh-H+ antiporter to facilitate the uptake of ACh. Interestingly, the VAChT gene is located within the first intron of the choline acetyltransferase gene (ChAT), the enzyme that catalyzes ACh synthesis from choline and acetyl coenzyme A. This may be to allow co-ordinated regulation of the two proteins.