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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC18A2 Gene

protein-coding   GIFtS: 64
GCID: GC10P119000

solute carrier family 18 (vesicular monoamine), member 2


(Previous symbol: VMAT2)
 Explore 41 diseases affiliated with
SLC18A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC18A2    

Aliases
for SLC18A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 18 (Vesicular Monoamine), Member 21 2     Solute Carrier Family 18 Member 22 3
SVMT1 2 3 5     Vesicular Amine Transporter 22 3
VMAT21 2 3     Monoamine Neurotransmitter Transporter2
VAT22 3 5     Synaptic Vesicular Amine Transporter2
SVAT1 2     Vesicle Monoamine Transporter Type 22
Monoamine Transporter2 3     Vesicle Monoamine/H+ Antiporter2

External Ids:    HGNC: 109351   Entrez Gene: 65712   Ensembl: ENSG000001656467   OMIM: 1930015   UniProtKB: Q059403   

Export aliases for SLC18A2 gene to outside databases

Previous GC identifers: GC10P117919 GC10P118244 GC10P119131 GC10P118665 GC10P118990 GC10P112628


Summaries
for SLC18A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC18A2:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton
gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity
of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is
a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 (PubMed
7905859)). See also SLC18A1 (MIM 193002).(supplied by OMIM, Jan 2011)

UniProtKB/Swiss-Prot: VMAT2_HUMAN, Q05940
Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic
monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for
vesicular amine storage prior to secretion via exocytosis

Gene Wiki entry for SLC18A2 (Vesicular monoamine transporter 2)


Genomic Views
for SLC18A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC18A2 gene promoter:
         CREB   COUP-TF   Sp1   deltaCREB   COUP   IRF-7A   HNF-4alpha2   HNF-3beta   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC18A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC18A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC18A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25

SLC18A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC18A2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P119000:  view genomic region     (about GC identifiers)

Start:
 119,000,584 bp from pter      End:
 119,038,941 bp from pter
Size:
 38,358 bases      Orientation:
 plus strand

Proteins
for SLC18A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VMAT2_HUMAN, Q05940 (See protein sequence)
Recommended Name: Synaptic vesicular amine transporter  
Size: 514 amino acids; 55713 Da
Subunit: Interacts with SLC6A3 (By similarity)
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAB19009.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RC96 D3DRC4 Q15876 Q5VW49 Q9H3P6

Explore the universe of human proteins at neXtProt for SLC18A2: NX_Q05940

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05940

    • SLC18A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003045.2  
    ENSEMBL proteins: 
     ENSP00000298472  
    Reactome Protein details: Q05940
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC18A2 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC18A2

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8095030
    GO:0008021synaptic vesicle ----


    SLC18A2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC18A2

    Protein Domains /
    Families
    for SLC18A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC18A2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q05940

    ProtoNet protein and cluster: Q05940

    UniProtKB/Swiss-Prot: VMAT2_HUMAN, Q05940
    Similarity: Belongs to the major facilitator superfamily. Vesicular transporter family


    Function
    for SLC18A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VMAT2_HUMAN, Q05940
    Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic
    monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for
    vesicular amine storage prior to secretion via exocytosis

         Genatlas biochemistry entry for SLC18A2:
    solute carrier family 18,member A2,vesicular monoamine transporter,expressed in brain

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC18A2 (see all 28):
    hsa-miR-142-5p hsa-miR-148b* hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-218 hsa-miR-550a* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: SLC18A2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC18A2 (see all 7)
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18A2

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005275amine transmembrane transporter activity ----
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--
    GO:0008504monoamine transmembrane transporter activity TAS8095030
    GO:0015222serotonin transmembrane transporter activity IEA--


    SLC18A2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC18A2:
     Increased homologous recombina 

    Animal Models:
         Mouse knock-outs for SLC18A2: Slc18a2tm1Mca Slc18a2tm1Kmo Slc18a2tm1Uhl Slc18a2tm1Edw
         11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Slc18a2):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size 
     homeostasis/metabolism  mortality/aging  muscle  nervous system  taste/olfaction 
     vision/eye 

    SLC18A2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC18A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Serotonin Neurotransmitter Release Cycle
    		Serotonin Neurotransmitter Release Cycle1.00
    		Norepinephrine Neurotransmitter Release Cycle0.60
    		Dopamine Neurotransmitter Release Cycle1.00
    3Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    4Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		Nicotine Activity on Dopaminergic Neurons0.44
    5Amine compound SLC transporters
    		Amine compound SLC transporters1.00
    		Na+/Cl- dependent neurotransmitter transporters0.63

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for SLC18A2 
        Nicotine Activity on Dopaminergic Neurons
    Synaptic Vesicle Pathway

    5/11        Reactome Pathways for SLC18A2 (see all 11)
        Transmission across Chemical Synapses
    Na+/Cl- dependent neurotransmitter transporters
    Amine compound SLC transporters
    Neurotransmitter Release Cycle
    Neuronal System

    3 PharmGKB Pathways for SLC18A2
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    1         Kegg Pathway  (Kegg details for SLC18A2):
        Parkinson's disease


    SLC18A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC18A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for SLC18A2 (Q059403 ENSP000002984724) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
    CSNK1A1P487293, ENSP000002617984I2D: score=1 STRING: ENSP00000261798
    CSNK2A1P684003, ENSP000002172444I2D: score=1 STRING: ENSP00000217244
    SLC6A3Q019593I2D: score=1 
    RAB3AENSP000002222564STRING: ENSP00000222256
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006836neurotransmitter transport ----
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007568aging IEA--


    SLC18A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC18A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC18A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC18A2

    1 HMDB Compound for SLC18A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--

    10/15 DrugBank Compounds for SLC18A2 (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Reserpine-- 50-55-5targetinhibitor17559790 20176067 17139284 11752352 17016423 8525459 1438304
    DeserpidineDeresperine (see all 7)131-01-1targetinhibitor17559790 11134 20176067 8525459 574544 1438304
    Ephedrine-- 299-42-3targetinhibitor21162110 17209801 15955613 7751968 19429089 21177475
    TetrabenazineTetra benazin (see all 5)58-46-8targetinhibitor11752352 19223416 20135628 17233532 20007701 19571144
    Alseroxylon-- 8001-95-4targetinhibitor13505370 17139284 11752352 17016423 13438725
    Methamphetamine(+ )-methylamphetamine (see all 46)537-46-2targetinhibitor17209801 15955613 7751968 19429089 21177475
    Isometheptene-- 503-01-5targetinhibitor15955613 3129549 7751968 15094323
    Propylhexedrine-- 3595-11-7targetinhibitor15955613 7751968 2874970 10794512
    EphedraChinese jointfir (see all 3)--targetinhibitor9587917 17209801 15955613
    MMDA(+-)-mmda (see all 7)13674-05-0targetinhibitor9587917 17209801 15955613

    10/72 Novoseek chemical compound relationships for SLC18A2 gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrotetrabenazine 92 19 19691331 (3), 20169578 (1), 12505801 (1), 11669473 (1) (see all 9)
    tetrabenazine 85.4 21 8621690 (3), 8643547 (1), 11375404 (1), 11669473 (1) (see all 11)
    dopamine 85.4 211 19855096 (6), 16005476 (4), 12505801 (4), 18815269 (4) (see all 99)
    nisoxetine 81.3 2 8523122 (1), 19376154 (1)
    norepinephrine 78.7 41 10720433 (3), 18674600 (2), 15520615 (1), 19053748 (1) (see all 32)
    lobeline 72.7 15 16107155 (5), 18191815 (4), 19855096 (2), 15121762 (1) (see all 6)
    2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 70.5 4 15080991 (2)
    methamphetamine 69.5 53 19855096 (6), 17683483 (3), 16622715 (3), 17637607 (3) (see all 17)
    cocaine 68.8 33 12505801 (5), 19969013 (2), 1350361 (1), 16245035 (1) (see all 22)
    tropane 66.1 3 16112864 (1), 16854064 (1), 11886784 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC18A2 / VMAT2 

    Transcripts
    for SLC18A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC18A2 gene: 
    NM_003054.4  

    Unigene Cluster for SLC18A2:

    Solute carrier family 18 (vesicular monoamine), member 2
    Hs.596992  [show with all ESTs]
    Unigene Representative Sequence: NM_003054
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298472(uc001ldd.2) ENST00000497497(uc009xyy.2)

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    hsa-miR-142-5p hsa-miR-148b* hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-218 hsa-miR-550a* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: SLC18A2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK314997.1 BC108927.1 BC108928.2 L09118.1 L14269.1 L23205.1 X71354.1 

    3 DOTS entries:

    DT.95155787  DT.454869  DT.92420706 

    24/55 AceView cDNA sequences (see all 55):

    N50002 CD243662 AI221017 AI221547 AA234125 L23205 BE673492 AI269290 
    AW993298 AV707549 BQ417167 CB217128 BE220883 CA774774 BE045637 BQ005306 
    BF446168 BM353823 L14269 BC030593 BX482788 BV192675 AI580967 L09118 

    GeneLoc Exon Structure


    Expression
    for SLC18A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC18A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTATGGTCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC18A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainSubstantia Nigra pars CompactaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainSubstantia Nigra pars CompactaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    OvaryPrimary FollicleGranulosa CellsOvary
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System

    See SLC18A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC18A2

    SOURCE GeneReport for Unigene cluster: Hs.596992
        SABiosciences Expression via Pathway-Focused PCR Array including SLC18A2: 
              Parkinson's Disease in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18A2

    Orthologs
    for SLC18A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC18A2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc18a21 , 5 solute carrier family 18 (vesicular monoamine), member more1, 5 88.89(n)1
    92.59(a)1    		   19 (54.64 cM)5
    2140841  NM_172523.31  NP_766111.11 
     592608785 
    chicken
    (Gallus gallus)    		 Aves SLC18A21 solute carrier family 18 (vesicular monoamine), member more 79.86(n)
    85.77(a)    		   423921  XM_421782.3  XP_421782.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC18A26
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343206.1(1369580-1415722)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc18a21 solute carrier family 18 (vesicular monoamine), member more 69.95(n)
    75.79(a)    		   553304  XM_002665190.1  XP_002665236.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG61193
    Vmat1    		 monoamine transporter3
    Vesicular monoamine transporter1    		 64(a)
    (best of 2)3
    58.5(n)1
    57.27(a)1    		   50A153
    33461921  NM_001014526.11  NP_001014526.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cat-11 , 3 synaptic vesicle amine transporter3
    Protein CAT-11    		 46(a)3
    55.72(n)1
    54(a)1    		   X(5740990-5742653)3
    1808371  NM_001029765.11  NP_001024936.11 


    ENSEMBL Gene Tree for SLC18A2 (if available)
    TreeFam Gene Tree for SLC18A2 (if available) 

    Paralogs
    for SLC18A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC18A2 gene
    SLC18B12  SLC18A12  SLC18A32  
    3 SIMAP similar genes for SLC18A2 using alignment to 2 protein entries:     VMAT2_HUMAN (see all proteins):
    VMAT2    SLC18A1    SLC18A3

    SLC18A2 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC18A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/810 NCBI SNPs in SLC18A2 are shown (see all 810)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1479508561,2
    		--118998687(+) CTCTAC/GGGGTG 1 -- us2k10--------
    rs1464500951,2
    		C,--118998706(+) CCGGA-/GGGCGG 1 -- us2k10--------
    rs599916561,2
    		C--118998709(+) GGAGG-/GCGGGA 1 -- us2k10--------
    rs1815086911,2
    		--118998750(+) TCTACA/TTCCAG 1 -- us2k10--------
    rs1175131551,2
    		F,--118998810(+) CTGCTA/GTCAGG 1 -- us2k11Minor allele frequency- G:0.04EA 120
    rs1402279531,2
    		--118998835(+) GGGATC/TTGTCT 1 -- us2k10--------
    rs1862860591,2
    		--118998892(+) TAAGAC/GCTCAA 1 -- us2k10--------
    rs1920411811,2
    		--118998907(+) TATTCA/CGCGCA 1 -- us2k10--------
    rs1817373631,2
    		--118998909(+) TTCAGC/TGCATG 1 -- us2k10--------
    rs111979311,2
    		C,F,H,--118998934(+) ACTTAC/TGGAGC 1 -- us2k16Minor allele frequency- T:0.11NS EA NA 658

    HapMap Linkage Disequilibrium report for SLC18A2 (119000584 - 119038941 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC18A2
         1 CNV: 39063

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    Disorders / Diseases
    for SLC18A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC18A2 for disorders           About GeneDecksing

    OMIM gene information: 193001    OMIM disorders: --

    20/41 diseases for SLC18A2 (see all 41):    About MalaCards
    dopa-responsive dystonia    attention deficit hyperactivity disorder    zollinger-ellison syndrome    langerhans-cell histiocytosis
    lewy body dementia    torsion dystonia    cocaine abuse    multiple endocrine neoplasia
    substance abuse    mastocytosis    nicotine dependence    tourette syndrome
    bipolar i disorder    toxic encephalopathy    anorexia nervosa    systemic mastocytosis
    neuroendocrine tumor    pancreatic endocrine tumors    bipolar disorder    histiocytosis

    3 diseases from the University of Copenhagen DISEASES database for SLC18A2:
    Parkinson's disease     Toxic encephalopathy     Schizophrenia

    10/29 Novoseek disease relationships for SLC18A2 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 66.7 23 10192785 (2), 8584980 (2), 9011752 (2), 16421508 (1) (see all 16)
    neurodegeneration 41.9 7 17988241 (2), 16594636 (1), 16386370 (1), 10499361 (1) (see all 5)
    lewy body disease 41.2 4 16386370 (1), 16258980 (1)
    neurodegenerative diseases 31.9 1 10974156 (1)
    attention-deficit hyperactivity disorder 31.6 3 15661632 (1), 16353949 (1), 15695060 (1)
    drug addiction 26.9 2 14730204 (1)
    carcinoid 25.5 6 10473967 (2), 11745679 (1), 11344233 (1), 15067176 (1)
    movement disorders 22.5 2 17344033 (1), 8832701 (1)
    schizophrenia 22.1 10 16139173 (3), 8825897 (2), 11519142 (1), 16353949 (1) (see all 6)
    cocaine dependence 21.9 1 10974156 (1)

    Genetic Association Database (GAD): SLC18A2
    Human Genome Epidemiology (HuGE) Navigator: SLC18A2 (17 documents)

    Export disorders for SLC18A2 gene to outside databases

    Publications
    for SLC18A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC18A2 gene, integrated from 9 sources (see all 360):
    (articles sorted by number of sources associating them with SLC18A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Lack of association between polymorphic microsatellites of the VMAT2 gene and Parkinson's disease in Japan. (PubMed id 15850588)1, 4, 9 Kariya S....Ueno S. (2005)
    2. Vesicular monoamine transporter 2: role as a novel target for drug development. (PubMed id 17233532)1, 7, 9 Zheng G....Crooks P.A. (2006)
    3. Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. (PubMed id 15988470)1, 4, 9 Schwab S.G....Wildenauer D.B. (2005)
    4. Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond. (PubMed id 12009896)1, 2, 9 Thiriot D.S.... Ruoho A.E. (2002)
    5. Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene. (PubMed id 11443533)1, 2, 9 Kunugi H.... Nanko S. (2001)
    6. Chromosomal localization of the human vesicular amine transporter genes. (PubMed id 7905859)1, 2, 9 Peter D.... Edwards R.H. (1993)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. (PubMed id 11279528)1, 4 Glatt C.E....Freimer N.B. (2001)
    10. Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the usceptibility to MPP+. (PubMed id 8373557)1, 2 Lesch K.P.... Riederer P. (1993)

    External Searches for SLC18A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing SLC18A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6571 HGNC: 10935 AceView: SLC18A2 Ensembl:ENSG00000165646 euGenes: HUgn6571
    ECgene: SLC18A2 Kegg: 6571 H-InvDB: SLC18A2

    Other Databases showing SLC18A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC18A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC18A2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Vesicular_monoamine_transporter

    Intellectual Property
    for SLC18A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC18A2 gene:
    Search GeneIP for patents involving SLC18A2

    GeneCards and IP:
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