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SLC18A2 Gene

protein-coding   GIFtS: 64
GCID: GC10P119000

Solute Carrier Family 18 (Vesicular Monoamine Transporter),...


(Previous symbol: VMAT2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member
21 2
     SVAT2
VMAT21 2 3     Monoamine Neurotransmitter Transporter2
SVMT2 3 5     Solute Carrier Family 18 (Vesicular Monoamine), Member 22
VAT22 3 5     Synaptic Vesicular Amine Transporter2
Monoamine Transporter2 3     Vesicle Monoamine Transporter Type 22
Solute Carrier Family 18 Member 22 3     Vesicle Monoamine/H+ Antiporter2
Vesicular Amine Transporter 22 3     

External Ids:    HGNC: 109351   Entrez Gene: 65712   Ensembl: ENSG000001656467   OMIM: 1930015   UniProtKB: Q059403   

Export aliases for SLC18A2 gene to outside databases

Previous GC identifers: GC10P117919 GC10P118244 GC10P119131 GC10P118665 GC10P118990 GC10P112628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC18A2 Gene:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the
proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the
correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric
disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary
by Peter et al., 1993 (PubMed 7905859)). See also SLC18A1 (MIM 193002).(supplied by OMIM, Jan 2011)

GeneCards Summary for SLC18A2 Gene:
SLC18A2 (solute carrier family 18 (vesicular monoamine transporter), member 2) is a protein-coding gene. Diseases associated with SLC18A2 include brain dopamine-serotonin vesicular transport disease, and parkinson disease 18. GO annotations related to this gene include heat shock protein binding and enzyme binding. An important paralog of this gene is SLC18B1.

UniProtKB/Swiss-Prot: VMAT2_HUMAN, Q05940
Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic
monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for
vesicular amine storage prior to secretion via exocytosis

Gene Wiki entry for SLC18A2 (Vesicular monoamine transporter 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC18A2 gene promoter:
         CREB   COUP-TF   Sp1   deltaCREB   COUP   IRF-7A   HNF-4alpha2   HNF-3beta   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC18A2 promoter sequence
   Search Chromatin IP Primers for SLC18A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC18A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25

SLC18A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC18A2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P119000:  view genomic region     (about GC identifiers)

Start:
119,000,584 bp from pter      End:
119,038,941 bp from pter
Size:
38,358 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VMAT2_HUMAN, Q05940 (See protein sequence)
Recommended Name: Synaptic vesicular amine transporter  
Size: 514 amino acids; 55713 Da
Subunit: Interacts with SLC6A3 (By similarity)
Sequence caution: Sequence=BAB19009.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RC96 D3DRC4 Q15876 Q5VW49 Q9H3P6

Explore the universe of human proteins at neXtProt for SLC18A2: NX_Q05940

Explore proteomics data for SLC18A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn84, Asn91
  • Modification sites at PhosphoSitePlus

  • See SLC18A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003045.2  
    ENSEMBL proteins: 
     ENSP00000298472  
    Reactome Protein details: Q05940

    SLC18A2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Vesicular monoamine transporter 2
    SLC18 family of vesicular amine transporters

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q05940

    ProtoNet protein and cluster: Q05940

    UniProtKB/Swiss-Prot: VMAT2_HUMAN, Q05940
    Similarity: Belongs to the major facilitator superfamily. Vesicular transporter family


    SLC18A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VMAT2_HUMAN, Q05940
    Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic
    monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for
    vesicular amine storage prior to secretion via exocytosis

         Genatlas biochemistry entry for SLC18A2:
    solute carrier family 18,member A2,vesicular monoamine transporter,expressed in brain

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005275amine transmembrane transporter activity IEA--
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--
    GO:0008504monoamine transmembrane transporter activity TAS8095030
    GO:0015222serotonin transmembrane transporter activity IEA--
         
    SLC18A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC18A2:
     Increased homologous recombina 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Slc18a2):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size/body 
     homeostasis/metabolism  mortality/aging  muscle  nervous system  taste/olfaction 
     vision/eye 

    SLC18A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC18A2: Slc18a2tm1Mca Slc18a2tm1Kmo Slc18a2tm1Uhl Slc18a2tm1Edw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC18A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC18A2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC18A2 (see all 28):
    hsa-miR-142-5p hsa-miR-148b* hsa-miR-607 hsa-miR-300 hsa-miR-200a hsa-miR-218 hsa-miR-550a* hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidSLC18A2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SLC18A2 (NM_003054)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VMAT2_HUMAN, Q05940: Cytoplasmic vesicle membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8095030
    GO:0008021synaptic vesicle ----
    GO:0016020membrane TAS8095030

    SLC18A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC18A2 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Na+/Cl- dependent neurotransmitter transporters0.00
    4Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle0.40
    Dopamine Neurotransmitter Release Cycle0.00
    Neurotransmitter Release Cycle0.32
    Norepinephrine Neurotransmitter Release Cycle0.00
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SLC18A2
        Nicotine Activity on Dopaminergic Neurons
    Synaptic Vesicle Pathway

    4 Reactome Pathways for SLC18A2
        Norepinephrine Neurotransmitter Release Cycle
    Dopamine Neurotransmitter Release Cycle
    Na+/Cl- dependent neurotransmitter transporters
    Serotonin Neurotransmitter Release Cycle

    3 PharmGKB Pathways for SLC18A2
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    Selected Kegg Pathways  (Kegg details for SLC18A2) (see all 7):
        Synaptic vesicle cycle
    Serotonergic synapse
    Dopaminergic synapse
    Parkinson's disease
    Cocaine addiction


    SLC18A2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC18A2: 
              Parkinson's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC18A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for SLC18A2 (Q059403 ENSP000002984724) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2A2P197843, ENSP000002625064I2D: score=1 STRING: ENSP00000262506
    SLC6A3Q019593, ENSP000002703494I2D: score=1 STRING: ENSP00000270349
    CSNK1A1P487293, ENSP000002617984I2D: score=1 STRING: ENSP00000261798
    CSNK2A1P684003, ENSP000002172444I2D: score=1 STRING: ENSP00000217244
    RAB3AENSP000002222564STRING: ENSP00000222256
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006836neurotransmitter transport ----
    GO:0006837serotonin transport ----
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--

    SLC18A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC18A2 (VMAT2)

    1 HMDB Compound for SLC18A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--

    Selected DrugBank Compounds for SLC18A2 (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Reserpine-- 50-55-5targetinhibitor17559790 20176067 17139284 11752352 17016423 8525459 1438304
    DeserpidineDeresperine (see all 7)131-01-1targetinhibitor17559790 11134 20176067 8525459 574544 1438304
    Ephedrine-- 299-42-3targetinhibitor21162110 17209801 15955613 7751968 19429089 21177475
    TetrabenazineRo 1-9569 (see all 7)58-46-8targetinhibitor11752352 19223416 20135628 17233532 20007701 19571144
    Alseroxylon-- 8001-95-4targetinhibitor13505370 17139284 11752352 17016423 13438725
    Methamphetamine(+ )-methylamphetamine (see all 46)537-46-2targetinhibitor17209801 15955613 7751968 19429089 21177475
    Isometheptene-- 503-01-5targetinhibitor15955613 3129549 7751968 15094323
    EphedraChinese jointfir (see all 3)--targetinhibitor9587917 17209801 15955613
    MMDA(+-)-mmda (see all 7)13674-05-0targetinhibitor9587917 17209801 15955613
    3,4-MethylenedioxymethamphetamineEcstasy (see all 2)42542-10-9targetinhibitor11861820 20002520

    7 IUPHAR Ligands for SLC18A2 (Vesicular monoamine transporter 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]TBZOH
    NoneNone8.28910293
    [125I]iodovinyl-TBZ
    NoneNone8.17855735
    reserpine
    InhibitorInhibition7.98643547
    tetrabenazine
    InhibitorInhibition78643547
    ketanserin
    InhibitorInhibition6.38643547
    [11C]DTBZ
    NoneNone6.3--
    [125I]8-azido-3-iodoketanserine
    NoneNone6.3--

    Selected Novoseek inferred chemical compound relationships for SLC18A2 gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrotetrabenazine 92 19 19691331 (3), 20169578 (1), 12505801 (1), 11669473 (1) (see all 9)
    tetrabenazine 85.4 21 8621690 (3), 8643547 (1), 11375404 (1), 11669473 (1) (see all 11)
    dopamine 85.4 211 19855096 (6), 16005476 (4), 12505801 (4), 18815269 (4) (see all 99)
    nisoxetine 81.3 2 8523122 (1), 19376154 (1)
    norepinephrine 78.7 41 10720433 (3), 18674600 (2), 15520615 (1), 19053748 (1) (see all 32)
    lobeline 72.7 15 16107155 (5), 18191815 (4), 19855096 (2), 15121762 (1) (see all 6)
    2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 70.5 4 15080991 (2)
    methamphetamine 69.5 53 19855096 (6), 17683483 (3), 16622715 (3), 17637607 (3) (see all 17)
    cocaine 68.8 33 12505801 (5), 19969013 (2), 1350361 (1), 16245035 (1) (see all 22)
    tropane 66.1 3 16112864 (1), 16854064 (1), 11886784 (1)



    SLC18A2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC18A2 gene: 
    NM_003054.4  

    Unigene Cluster for SLC18A2:

    Solute carrier family 18 (vesicular monoamine), member 2
    Hs.596992  [show with all ESTs]
    Unigene Representative Sequence: NM_003054
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298472(uc001ldd.2) ENST00000497497(uc009xyy.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC18A2

    Additional mRNA sequence: 

    AK314997.1 BC108927.1 BC108928.2 L09118.1 L14269.1 L23205.1 X71354.1 

    3 DOTS entries:

    DT.95155787  DT.454869  DT.92420706 

    Selected AceView cDNA sequences (see all 55):

    CD243662 AI221017 AA234125 N50002 AI221547 L23205 BG718762 CA774774 
    BQ417167 BV175809 BQ005306 AU129190 AI580967 BX281756 BM353552 NM_003054 
    BE467071 AV707549 CA771931 BM353823 T28323 BE045637 L14269 BX482788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SLC18A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATGGTCG
    SLC18A2 Expression
    About this image


    SLC18A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Midbrain tegmentum
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
             Secondary follicles
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    SLC18A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC18A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596992
        Pathway & Disease-focused RT2 Profiler PCR Array including SLC18A2: 
              Parkinson's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC18A2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc18a21 , 5 solute carrier family 18 (vesicular monoamine), member more1, 5 88.89(n)1
    92.59(a)1
      19 (54.64 cM)5
    2140841  NM_172523.31  NP_766111.11 
     592608785 
    chicken
    (Gallus gallus)
    Aves SLC18A21 solute carrier family 18 (vesicular monoamine), member more 79.86(n)
    85.77(a)
      423921  XM_421782.4  XP_421782.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC18A26
    solute carrier family 18 (vesicular monoamine tran...
    81(a)
    1 ↔ 1
    GL343206.1(1367534-1416159)
    zebrafish
    (Danio rerio)
    Actinopterygii slc18a21 solute carrier family 18 (vesicular monoamine), member more 70.36(n)
    76.63(a)
      553304  NM_001256225.2  NP_001243154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61193
    Vmat1
    monoamine transporter3
    Vesicular monoamine transporter1
    64(a)
    (best of 2)3
    58(n)1
    56.5(a)1
      50A153
    33461921  NM_001014524.21  NP_001014524.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cat-11 , 3 synaptic vesicle amine transporter3
    cat-11
    46(a)3
    55.44(n)1
    54.43(a)1
      X(5740990-5742653)3
    1808371  NM_001029765.11  NP_001024936.11 


    ENSEMBL Gene Tree for SLC18A2 (if available)
    TreeFam Gene Tree for SLC18A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC18A2 gene
    SLC18B12  SLC18A12  SLC18A32  
    3 SIMAP similar genes for SLC18A2 using alignment to 2 protein entries:     VMAT2_HUMAN (see all proteins):
    VMAT2    SLC18A1    SLC18A3

    SLC18A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC18A2 (see all 977)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479508561,2
    C--118998687(+) CTCTAC/GGGGTG 1 -- us2k10--------
    rs599916561,2
    C--118998708(+) GGAGG-/GCGGGA 1 -- us2k10--------
    rs1815086911,2
    --118998750(+) TCTACA/TTCCAG 1 -- us2k10--------
    rs1175131551,2
    F--118998810(+) CTGCTA/GTCAGG 1 -- us2k11Minor allele frequency- G:0.04EA 120
    rs1402279531,2
    --118998835(+) GGGATC/TTGTCT 1 -- us2k10--------
    rs1862860591,2
    --118998892(+) TAAGAC/GCTCAA 1 -- us2k10--------
    rs1920411811,2
    --118998907(+) TATTCA/CGCGCA 1 -- us2k10--------
    rs1817373631,2
    --118998909(+) TTCAGC/TGCATG 1 -- us2k10--------
    rs111979311,2
    C,F,H--118998934(+) ACTTAC/TGGAGC 1 -- us2k16Minor allele frequency- T:0.11NS EA NA 658
    rs767994471,2
    F--118998935(+) CTTACG/AGAGCT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for SLC18A2 (119000584 - 119038941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC18A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7564CNV Insertion18451855
    nsv896038CNV Gain21882294
    nsv832002CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): SLC18A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC18A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC18A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 193001    OMIM disorders: --

    Selected diseases for SLC18A2 (see all 46):    
    About MalaCards
    brain dopamine-serotonin vesicular transport disease    parkinson disease 18    cocaine dependence    zollinger-ellison syndrome
    torsion dystonia    lewy body dementia    cocaine abuse    mastocytosis
    systemic mastocytosis    bipolar i disorder    attention deficit hyperactivity disorder    phaeochromocytoma
    langerhans-cell histiocytosis    toxic encephalopathy    substance abuse    pancreatic endocrine tumors
    neuroendocrine tumor    histiocytosis    mood disorder    parkinson's disease

    3 diseases from the University of Copenhagen DISEASES database for SLC18A2:
    Parkinson's disease     Toxic encephalopathy     Schizophrenia

    SLC18A2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SLC18A2 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 66.7 23 10192785 (2), 8584980 (2), 9011752 (2), 16421508 (1) (see all 16)
    neurodegeneration 41.9 7 17988241 (2), 16594636 (1), 16386370 (1), 10499361 (1) (see all 5)
    lewy body disease 41.2 4 16386370 (1), 16258980 (1)
    neurodegenerative diseases 31.9 1 10974156 (1)
    attention-deficit hyperactivity disorder 31.6 3 15661632 (1), 16353949 (1), 15695060 (1)
    drug addiction 26.9 2 14730204 (1)
    carcinoid 25.5 6 10473967 (2), 11745679 (1), 11344233 (1), 15067176 (1)
    movement disorders 22.5 2 17344033 (1), 8832701 (1)
    schizophrenia 22.1 10 16139173 (3), 8825897 (2), 11519142 (1), 16353949 (1) (see all 6)
    cocaine dependence 21.9 1 10974156 (1)

    Genetic Association Database (GAD): SLC18A2
    Human Genome Epidemiology (HuGE) Navigator: SLC18A2 (17 documents)

    Export disorders for SLC18A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC18A2 gene, integrated from 10 sources (see all 372):
    (articles sorted by number of sources associating them with SLC18A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lack of association between polymorphic microsatellites of the VMAT2 gene and Parkinson's disease in Japan. (PubMed id 15850588)1, 4, 9 Kariya S....Ueno S. (J. Neurol. Sci. 2005)
    2. Vesicular monoamine transporter 2: role as a novel target for drug development. (PubMed id 17233532)1, 7, 9 Zheng G....Crooks P.A. (AAPS J 2006)
    3. Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. (PubMed id 15988470)1, 4, 9 Schwab S.G....Wildenauer D.B. (Neuropsychopharmacology 2005)
    4. Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond. (PubMed id 12009896)1, 2, 9 Thiriot D.S.... Ruoho A.E. (Biochemistry 2002)
    5. Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene. (PubMed id 11443533)1, 2, 9 Kunugi H.... Nanko S. (Mol. Psychiatry 2001)
    6. Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome. (PubMed id 18797399)1, 4, 9 Crowley J.J....Berrettini W.H. (Psychiatr. Genet. 2008)
    7. Chromosomal localization of the human vesicular amine transporter genes. (PubMed id 7905859)1, 2, 9 Peter D.... Edwards R.H. (Genomics 1993)
    8. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)1, 4 van Winkel R. (Arch. Gen. Psychiatry 2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6571 HGNC: 10935 AceView: SLC18A2 Ensembl:ENSG00000165646 euGenes: HUgn6571
    ECgene: SLC18A2 Kegg: 6571 H-InvDB: SLC18A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC18A2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Vesicular_monoamine_transporter

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC18A2 gene:
    Search GeneIP for patents involving SLC18A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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