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Aliases for SLC18A2 Gene

Aliases for SLC18A2 Gene

  • Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 2 2 3
  • SVMT 3 4 6
  • VAT2 3 4 6
  • Solute Carrier Family 18 Member 2 3 4
  • Vesicular Amine Transporter 2 3 4
  • Monoamine Transporter 3 4
  • VMAT2 3 4
  • Solute Carrier Family 18 (Vesicular Monoamine), Member 2 3
  • Monoamine Neurotransmitter Transporter 3
  • Synaptic Vesicular Amine Transporter 3
  • Vesicle Monoamine Transporter Type 2 3
  • Vesicle Monoamine/H+ Antiporter 3
  • SVAT 3

External Ids for SLC18A2 Gene

Previous HGNC Symbols for SLC18A2 Gene

  • VMAT2

Previous GeneCards Identifiers for SLC18A2 Gene

  • GC10P117919
  • GC10P118244
  • GC10P119131
  • GC10P118665
  • GC10P118990
  • GC10P112628
  • GC10P119000

Summaries for SLC18A2 Gene

Entrez Gene Summary for SLC18A2 Gene

  • The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC18A2 Gene

SLC18A2 (Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC18A2 include brain dopamine-serotonin vesicular transport disease and torsion dystonia. Among its related pathways are Amphetamine addiction and Circadian entrainment. GO annotations related to this gene include enzyme binding and heat shock protein binding. An important paralog of this gene is SLC18B1.

UniProtKB/Swiss-Prot for SLC18A2 Gene

  • Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis

Gene Wiki entry for SLC18A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC18A2 Gene

Genomics for SLC18A2 Gene

Regulatory Elements for SLC18A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC18A2 Gene

Start:
117,241,073 bp from pter
End:
117,279,430 bp from pter
Size:
38,358 bases
Orientation:
Plus strand

Genomic View for SLC18A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC18A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC18A2 Gene

Proteins for SLC18A2 Gene

  • Protein details for SLC18A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05940-VMAT2_HUMAN
    Recommended name:
    Synaptic vesicular amine transporter
    Protein Accession:
    Q05940
    Secondary Accessions:
    • B2RC96
    • D3DRC4
    • Q15876
    • Q4G147
    • Q5VW49
    • Q9H3P6

    Protein attributes for SLC18A2 Gene

    Size:
    514 amino acids
    Molecular mass:
    55713 Da
    Quaternary structure:
    • Interacts with SLC6A3.
    SequenceCaution:
    • Sequence=BAB19009.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC18A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC18A2 Gene

Proteomics data for SLC18A2 Gene at MOPED

Post-translational modifications for SLC18A2 Gene

  • Glycosylation at Asn56, Asn84, and Asn91
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC18A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC18A2 Gene

Domains for SLC18A2 Gene

Gene Families for SLC18A2 Gene

Protein Domains for SLC18A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC18A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q05940

UniProtKB/Swiss-Prot:

VMAT2_HUMAN :
  • Q05940
Family:
  • Belongs to the major facilitator superfamily. Vesicular transporter family.
genes like me logo Genes that share domains with SLC18A2: view

Function for SLC18A2 Gene

Molecular function for SLC18A2 Gene

GENATLAS Biochemistry: solute carrier family 18,member A2,vesicular monoamine transporter,expressed in brain
UniProtKB/Swiss-Prot Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis

Gene Ontology (GO) - Molecular Function for SLC18A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005275 amine transmembrane transporter activity IEA --
GO:0005515 protein binding --
GO:0008144 drug binding IEA --
GO:0008504 monoamine transmembrane transporter activity TAS 8095030
GO:0015222 serotonin transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC18A2: view
genes like me logo Genes that share phenotypes with SLC18A2: view

Animal Models for SLC18A2 Gene

MGI Knock Outs for SLC18A2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC18A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC18A2 Gene

Localization for SLC18A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC18A2 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC18A2 Gene COMPARTMENTS Subcellular localization image for SLC18A2 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC18A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8095030
GO:0008021 synaptic vesicle TAS 21563316
GO:0016020 membrane TAS 8095030
genes like me logo Genes that share ontologies with SLC18A2: view

Pathways for SLC18A2 Gene

genes like me logo Genes that share pathways with SLC18A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC18A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006836 neurotransmitter transport --
GO:0006837 serotonin transport IEA --
GO:0007268 synaptic transmission TAS 15217342
GO:0007269 neurotransmitter secretion TAS --
genes like me logo Genes that share ontologies with SLC18A2: view

Compounds for SLC18A2 Gene

(1) Tocris Compounds for SLC18A2 Gene

Compound Action Cas Number
Rose Bengal Potent VGlut and VMAT inhibitor; cell permeable [632-69-9]

(1) HMDB Compounds for SLC18A2 Gene

Compound Synonyms Cas Number PubMed IDs
Histamine
  • 1H-Imidazole-4-ethanamine
51-45-6

(15) Drugbank Compounds for SLC18A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3,4-Methylenedioxymethamphetamine
  • Ecstasy
42542-10-9 target inhibitor
4-Methoxyamphetamine
23239-32-9 target inhibitor
Alseroxylon
8001-95-4 target inhibitor
Amphetamine
  • (+/-)-Benzedrine
300-62-9 target inhibitor
Benzphetamine
  • Benzfetamine
156-08-1 target inducer

(7) IUPHAR Ligand for SLC18A2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]TBZOH None None 8.2
[125I]iodovinyl-TBZ None None 8.1
reserpine Inhibitor Inhibition 7.9
tetrabenazine Inhibitor Inhibition 7
ketanserin Inhibitor Inhibition 6.3
[11C]DTBZ None None
[125I]8-azido-3-iodoketanserine None None

(72) Novoseek inferred chemical compound relationships for SLC18A2 Gene

Compound -log(P) Hits PubMed IDs
dihydrotetrabenazine 92 11
tetrabenazine 85.4 13
dopamine 85.4 142
nisoxetine 81.3 2
norepinephrine 78.7 35
genes like me logo Genes that share compounds with SLC18A2: view

Transcripts for SLC18A2 Gene

mRNA/cDNA for SLC18A2 Gene

Unigene Clusters for SLC18A2 Gene

Solute carrier family 18 (vesicular monoamine), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC18A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC18A2 Gene

No ASD Table

Relevant External Links for SLC18A2 Gene

GeneLoc Exon Structure for
SLC18A2
ECgene alternative splicing isoforms for
SLC18A2

Expression for SLC18A2 Gene

mRNA expression in normal human tissues for SLC18A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC18A2 Gene

This gene is overexpressed in Brain - Substantia nigra (7.0) and Brain - Hypothalamus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC18A2 Gene

SOURCE GeneReport for Unigene cluster for SLC18A2 Gene Hs.596992

genes like me logo Genes that share expressions with SLC18A2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC18A2 Gene

Orthologs for SLC18A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC18A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC18A2 35
  • 99.74 (n)
  • 99.81 (a)
SLC18A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC18A2 35
  • 89.3 (n)
  • 91.63 (a)
SLC18A2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC18A2 35
  • 90.14 (n)
  • 92.41 (a)
SLC18A2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc18a2 35
  • 88.89 (n)
  • 92.59 (a)
Slc18a2 16
Slc18a2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC18A2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC18A2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc18a2 35
  • 88.17 (n)
  • 92.55 (a)
chicken
(Gallus gallus)
Aves SLC18A2 35
  • 79.86 (n)
  • 85.77 (a)
SLC18A2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC18A2 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc18a2 35
  • 70.36 (n)
  • 76.63 (a)
slc18a2 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004476 35
  • 59.79 (n)
  • 58.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vmat 35
  • 58 (n)
  • 56.5 (a)
Vmat 36
  • 42 (a)
OneToMany
CG10251 37
  • 34 (a)
CG6119 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea cat-1 35
  • 55.44 (n)
  • 54.43 (a)
cat-1 36
  • 45 (a)
OneToMany
cat-1 37
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for SLC18A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC18A2 Gene

ENSEMBL:
Gene Tree for SLC18A2 (if available)
TreeFam:
Gene Tree for SLC18A2 (if available)

Paralogs for SLC18A2 Gene

Paralogs for SLC18A2 Gene

Selected SIMAP similar genes for SLC18A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC18A2: view

Variants for SLC18A2 Gene

Sequence variations from dbSNP and Humsavar for SLC18A2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs363220 -- 117,257,179(+) CAGAA(C/T)GATGG intron-variant
rs363221 -- 117,258,520(+) GTGGC(C/T)ATGTT intron-variant
rs363222 -- 117,259,937(+) TTACT(C/G)CAGTT intron-variant
rs363223 -- 117,263,050(+) CAGAC(A/G)TTCAC intron-variant
rs363224 -- 117,263,062(+) CAACC(A/C)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC18A2 Gene

Variant ID Type Subtype PubMed ID
nsv832002 CNV Gain+Loss 17160897
nsv896038 CNV Gain 21882294
nsv7564 CNV Insertion 18451855

Relevant External Links for SLC18A2 Gene

HapMap Linkage Disequilibrium report
SLC18A2
Human Gene Mutation Database (HGMD)
SLC18A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC18A2 Gene

Disorders for SLC18A2 Gene

(3) University of Copenhagen DISEASES for SLC18A2 Gene

(29) Novoseek inferred disease relationships for SLC18A2 Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 66.7 19
neurodegeneration 41.9 6
lewy body disease 41.2 2
neurodegenerative diseases 31.9 1
attention-deficit hyperactivity disorder 31.6 3

Relevant External Links for SLC18A2

Genetic Association Database (GAD)
SLC18A2
Human Genome Epidemiology (HuGE) Navigator
SLC18A2
genes like me logo Genes that share disorders with SLC18A2: view

No data available for UniProtKB/Swiss-Prot for SLC18A2 Gene

Publications for SLC18A2 Gene

  1. Chromosomal localization of the human vesicular amine transporter genes. (PMID: 7905859) Peter D. … Edwards R.H. (Genomics 1993) 3 4 23
  2. Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene. (PMID: 11443533) Kunugi H. … Nanko S. (Mol. Psychiatry 2001) 3 4 23
  3. Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond. (PMID: 12009896) Thiriot D.S. … Ruoho A.E. (Biochemistry 2002) 3 4 23
  4. Lack of association between polymorphic microsatellites of the VMAT2 gene and Parkinson's disease in Japan. (PMID: 15850588) Kariya S. … Ueno S. (J. Neurol. Sci. 2005) 3 23 48
  5. Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. (PMID: 15988470) Schwab S.G. … Wildenauer D.B. (Neuropsychopharmacology 2005) 3 23 48

Products for SLC18A2 Gene

Sources for SLC18A2 Gene

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