Aliases for SLC18A1 Gene
External Ids for SLC18A1 Gene
Previous HGNC Symbols for SLC18A1 Gene
Previous GeneCards Identifiers for SLC18A1 Gene
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC18A1 Gene
SLC18A1 (Solute Carrier Family 18 Member A1) is a Protein Coding gene. Diseases associated with SLC18A1 include Paranoid Schizophrenia and Brain Stem Cancer. Among its related pathways are Synaptic vesicle cycle and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include monoamine transmembrane transporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC18A2.
UniProtKB/Swiss-Prot for SLC18A1 Gene
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.