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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC18A1 Gene

protein-coding GIFtS: 59
GCID: GC08M020046

solute carrier family 18 (vesicular monoamine), member 1

(Previous symbols: VMAT1, VAT1)

Explore 17 diseases affiliated with
SLC18A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 18 (Vesicular Monoamine), Member 1¹ ²		Solute Carrier Family 18 Member 1² ³
VAT1¹ ² ³ ⁵		Vesicular Amine Transporter 1² ³
VMAT1¹ ² ³ ⁵		Chromaffin Granule Amine Transporter²
CGAT¹ ² ⁵

External Ids:	HGNC: 10934¹	Entrez Gene: 6570²	Ensembl: ENSG00000036565⁷	OMIM: 193002⁵	UniProtKB: P54219³

Export aliases for SLC18A1 gene to outside databases

Previous GC identifers: GC08M019877 GC08M020064 GC08M020012 GC08M018542

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC18A1:

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient

maintained across the vesicular membrane. Its proper function is essential to the correct activity of the

monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site

of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 (PubMed 7905859)). See also

SLC18A2 (MIM 193001).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: VMAT1_HUMAN, P54219

Function: Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory

vesicles of neuroendocrine and endocrine cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC18A1 gene promoter:
AML1a NRSF form 1 NRSF form 2 YY1 Arnt Evi-1 C/EBPalpha Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC18A1 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC18A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC18A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.3

SLC18A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC18A1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M020046: view genomic region (about GC identifiers)

Start:	20,002,366 bp from pter	End:	20,040,717 bp from pter
Size:	38,352 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VMAT1_HUMAN, P54219 (See protein sequence)

Recommended Name: Chromaffin granule amine transporter

Size: 525 amino acids; 56257 Da

Subcellular location: Isoform 1: Cytoplasmic vesicle membrane; Multi-pass membrane protein

Subcellular location: Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein

Secondary accessions: E9PDJ5 Q9BRE4

Alternative splicing: 3 isoforms: P54219-1 P54219-2 P54219-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC18A1: NX_P54219

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P54219

SLC18A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001129163.1 NP_001135796.1 NP_001135797.1 NP_003044.1

ENSEMBL proteins:

ENSP00000265808 ENSP00000276373 ENSP00000428001 ENSP00000429664 ENSP00000371021

ENSP00000428999 ENSP00000387549 ENSP00000413361

Reactome Protein details: P54219
Human Recombinant Protein Products:

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	Uscn Proteins for SLC18A1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0016020	membrane	NAS	--
GO:0016021	integral to membrane	IEA	--
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane	TAS	--

SLC18A1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SLC18A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC18A1 for domains About GeneDecksing

4 InterPro domains/families:

IPR004734 Multidrug-R

IPR020846 MFS_dom

IPR011701 MFS

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry P54219

ProtoNet protein and cluster: P54219

UniProtKB/Swiss-Prot: VMAT1_HUMAN, P54219

Similarity: Belongs to the major facilitator superfamily. Vesicular transporter family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VMAT1_HUMAN, P54219

Function: Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory

vesicles of neuroendocrine and endocrine cells

Genatlas biochemistry entry for SLC18A1:

solute carrier family 18,member A1,vesicular monoamine transporter,expressed in adrenals

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18A1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008504	monoamine transmembrane transporter activity	TAS	8643547
GO:0015222	serotonin transmembrane transporter activity	--	--
GO:0015238	drug transmembrane transporter activity	IEA	--
GO:0019899	enzyme binding	--	--

SLC18A1 for ontologies About GeneDecksing

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Slc18a1):

normal

SLC18A1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Amine compound SLC transporters

Amine compound SLC transporters

1.00

Na+/Cl- dependent neurotransmitter transporters

0.63

Sympathetic Nerve Pathway (Neuroeffector Junction)

Sympathetic Nerve Pathway (Neuroeffector Junction)

1.00

Synaptic Vesicle Pathway

Synaptic Vesicle Pathway

1.00

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Parkinson's disease

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SLC18A1

Synaptic Vesicle Pathway

5 Reactome Pathways for SLC18A1

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Na+/Cl- dependent neurotransmitter transporters
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Amine compound SLC transporters

1 PharmGKB Pathway for SLC18A1

Sympathetic Nerve Pathway (Neuroeffector Junction)

1 Kegg Pathway (Kegg details for SLC18A1):

Parkinson's disease

SLC18A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC18A1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SLC18A1 (ENSP00000276373⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIRT1	ENSP00000212015⁴	STRING: ENSP00000212015
SIRT2	ENSP00000249396⁴	STRING: ENSP00000249396

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006836	neurotransmitter transport	IEA	--
GO:0015844	monoamine transport	TAS	8643547
GO:0033603	positive regulation of dopamine secretion	--	--
GO:0051610	serotonin uptake	--	--
GO:0051612	negative regulation of serotonin uptake	--	--

SLC18A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC18A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC18A1

3 DrugBank Compounds for SLC18A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ephedra	Chinese jointfir (see all 3)	--	target	inhibitor	9587917 17209801 15955613
MMDA	(+-)-mmda (see all 7)	13674-05-0	target	inhibitor	9587917 17209801 15955613
Methamphetamine	(+ )-methylamphetamine (see all 46)	537-46-2	target	inhibitor	9587917 17209801 15955613

4 Novoseek chemical compound relationships for SLC18A1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amine	55.5	4	7905859 (1)
acetylcholine	38.6	2	12827358 (1)
dopamine	35.5	1	12955095 (1)
tyrosine	0	1	11431013 (1)

Search CenterWatch for drugs/clinical trials and news about SLC18A1 / VMAT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC18A1 gene (4 alternative transcripts):

NM_001135691.2 NM_001142324.1 NM_001142325.1 NM_003053.3

Unigene Cluster for SLC18A1:

Solute carrier family 18 (vesicular monoamine), member 1

Hs.158322 [show with all ESTs]

Unigene Representative Sequence: NM_001135691

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265808 ENST00000276373(uc003wzm.3) ENST00000517776(uc010ltf.3)

ENST00000519026 ENST00000381608 ENST00000519171 ENST00000522513 ENST00000524272

ENST00000440926(uc011kyq.2 uc003wzn.3) ENST00000437980(uc011kyr.2)

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Additional cDNA sequence:

AK313720.1 BC006317.2 U39905.1

5 DOTS entries:

DT.100782690 DT.100744163 DT.91682585 DT.100711569 DT.100782691

24/38 AceView cDNA sequences (see all 38):

BX332143 CR621905 CR612722 BQ723381 BX375143 AL526410 CR593627 BX417564

CR604993 U39905 BC009387 BX352730 BX394451 BX283515 BX376808 BF311109

BF206788 NM_003053 BQ917568 BC006317 BQ888153 BX464415 BF312994 BX353151

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC18A1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19
SP1:							-								-														-
SP2:							-								-														-						-
SP3:															-												-		-						-
SP4:
SP5:

ECgene alternative splicing isoforms for SLC18A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC18A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGAAGTT

About this image

SLC18A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Proximal Tubule

Proximal Tubule Cells

Kidney

Placenta

Chorioallantoic Placenta

Extraembryonic Angioblasts

Endothelium

Kidney

Kidney

Kidney

Limb

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Midbrain dopaminergic-like neurons (Generation of midbra...)

See SLC18A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC18A1

SOURCE GeneReport for Unigene cluster: Hs.158322

SABiosciences Expression via Pathway-Focused PCR Array including SLC18A1:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC18A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC18A1 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC18A1¹	solute carrier family 18 (vesicular monoamine), member more	71.25(n) 74.46(a)		431330 XM_428881.2 XP_428881.2
lizard (Anolis carolinensis)	Reptilia	SLC18A1⁶	--	69(a)	1 ↔ 1	GL343238.1(1007693-1032665)
African clawed frog (Xenopus laevis)	Amphibia	BC041717.1²	--	70.34(n)		BC041717.1
zebrafish (Danio rerio)	Actinopterygii	LOC100331899¹	chromaffin granule amine transporter-like	66.73(n) 69.51(a)		100331899 XM_002663216.2 XP_002663262.2
fruit fly (Drosophila melanogaster)	Insecta	CG6119³	monoamine transporter	63(a) (best of 2)		50A15 --
worm (Caenorhabditis elegans)	Secernentea	cat-1³	synaptic vesicle amine transporter	42(a)		X(5740990-5742653) --

ENSEMBL Gene Tree for SLC18A1 (if available)
TreeFam Gene Tree for SLC18A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC18A1 gene

SLC18B1² SLC18A2² SLC18A3²

3 SIMAP similar genes for SLC18A1 using alignment to 5 protein entries: VMAT1_HUMAN (see all proteins):

SLC18A2 VMAT2 SLC18A3

SLC18A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190406032^1,2		--	20001876(+)	`ATCATC/TTGCAT`	4	--	int¹		0	--	--	--	--
rs148779538^1,2		--	20001883(+)	`GCATGA/GTGAAG`	4	--	int¹		0	--	--	--	--
rs7003858^1,2	C,F,A,H,	--	20001995(+)	`TCCAGA/GTAAAG`	4	--	int¹		30		EA NA NS WA CSA	2750
rs117104706^1,2	F,	--	20002094(+)	`TATTTC/ACCACC`	4	--	int¹		1		EA	120
rs142398531^1,2		--	20002126(+)	`GTTCAC/TACTTG`	4	--	int¹		0	--	--	--	--
rs116313826^1,2	F,	--	20002253(+)	`ATCCCA/GTCACC`	4	--	int¹		1		WA	118
rs17092083^1,2	C,F,H,	--	20002256(+)	`CCATCA/GCCCAA`	4	--	int¹		8		NA NS EA WA	678
rs147969117^1,2		--	20002319(+)	`ATTTGC/GCCATA`	4	--	int¹		0	--	--	--	--
rs74972179^1,2	C,F,	--	20002350(+)	`CAACAT/CCTAGT`	4	--	int¹		1		WA	118
rs182782180^1,2		--	20002402(+)	`TATGAA/GCAATG`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC18A1 (20002366 - 20040717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SLC18A1
3 CNVs: 1775 2745 31433
Human Gene Mutation Database (HGMD): SLC18A1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC18A1 for disorders           About GeneDecksing

OMIM gene information: 193002    OMIM disorders: --

17 diseases for SLC18A1:    About MalaCards

bipolar i disorder anorexia nervosa systemic mastocytosis mastocytosis

pancreatic endocrine tumors histiocytosis neuroendocrine tumor parkinson's disease

schizophrenia pharyngitis pancreatitis cholesterol

neuronitis

1 disease from the University of Copenhagen DISEASES database for SLC18A1:

Schizophrenia

3 Novoseek disease relationships for SLC18A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoid	53	4	10473967 (2), 11745679 (1)
schizophrenia	32.8	5	17134514 (3), 20419435 (2)
tumors	0	8	12871984 (4), 11159212 (2), 10473967 (1)

Human Genome Epidemiology (HuGE) Navigator: SLC18A1 (8 documents)

Export disorders for SLC18A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC18A1 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with SLC18A1)

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Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1. (PubMed id 16326835)^{1, 2, 9} Essand M....Giandomenico V. (2005)
Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. (PubMed id 8643547)^{1, 2, 9} Erickson J.D.... Weihe E. (1996)
Expression of the two isoforms of the vesicular monoamine transporter (VMAT1 and VMAT2) in the endocrine pancreas and pancreatic endocrine tumors. (PubMed id 12871984)^{1, 9} Anlauf M....Weihe E. (2003)
Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population. (PubMed id 17134514)^{1, 9} Richards M....Kunugi H. (2006)
Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia. (PubMed id 18451639)^{1, 9} Lohoff F.W....Berrettini W.H. (2008)
Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. (PubMed id 16936705)^{1, 9} Lohoff F.W....Berrettini W.H. (2006)
Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. (PubMed id 11431013)^{1, 9} Amenta F....Tayebati S.K. (2001)
Chromosomal localization of the human vesicular amine transporter genes. (PubMed id 7905859)^{1, 9} Peter D.... Edwards R.H. (1993)
Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits. (PubMed id 18249496)^{1, 9} Lohoff F.W....Gallinat J. (2008)
The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine. (PubMed id 12827358)^{1, 9} Eiden L.E....Schutz B. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6570	HGNC: 10934	AceView: SLC18A1	Ensembl:ENSG00000036565	euGenes: HUgn6570
ECgene: SLC18A1	Kegg: 6570	H-InvDB: SLC18A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC18A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC18A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC18A1 gene:
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SLC18A1 Gene

solute carrier family 18 (vesicular monoamine), member 1

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SLC18A1 Gene

solute carrier family 18 (vesicular monoamine), member 1

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