Aliases for SLC18A1 Gene
External Ids for SLC18A1 Gene
Previous HGNC Symbols for SLC18A1 Gene
Previous GeneCards Identifiers for SLC18A1 Gene
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC18A1 Gene
SLC18A1 (Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Amphetamine addiction and Circadian entrainment. GO annotations related to this gene include drug transmembrane transporter activity and monoamine transmembrane transporter activity. An important paralog of this gene is SLC18A2.
UniProtKB/Swiss-Prot for SLC18A1 Gene
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.