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Aliases for SLC18A1 Gene

Aliases for SLC18A1 Gene

  • Solute Carrier Family 18 Member A1 2 3 5
  • Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 1 2 3
  • Solute Carrier Family 18 Member 1 3 4
  • Vesicular Amine Transporter 1 3 4
  • VMAT1 3 4
  • VAT1 3 4
  • Solute Carrier Family 18 (Vesicular Monoamine), Member 1 3
  • Chromaffin Granule Amine Transporter 3
  • CGAT 3

External Ids for SLC18A1 Gene

Previous HGNC Symbols for SLC18A1 Gene

  • VMAT1
  • VAT1

Previous GeneCards Identifiers for SLC18A1 Gene

  • GC08M019877
  • GC08M020064
  • GC08M020012
  • GC08M020046
  • GC08M018542
  • GC08M020002

Summaries for SLC18A1 Gene

Entrez Gene Summary for SLC18A1 Gene

  • The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC18A1 Gene

SLC18A1 (Solute Carrier Family 18 Member A1) is a Protein Coding gene. Diseases associated with SLC18A1 include Paranoid Schizophrenia and Schizophrenia. Among its related pathways are Synaptic vesicle cycle and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include monoamine transmembrane transporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC18A2.

UniProtKB/Swiss-Prot for SLC18A1 Gene

  • Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC18A1 Gene

Genomics for SLC18A1 Gene

Regulatory Elements for SLC18A1 Gene

Enhancers for SLC18A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F020156 0.5 ENCODE 19.3 +25.1 25133 2.9 SLC18A1 GC08M020154
GH08F020133 0.8 ENCODE 10.9 +49.5 49464 0.1 CTCF ZNF362 ZNF654 MAFG REST RAD21 ZNF316 KLF16 ZNF143 SMC3 SLC18A1 LOC105379311 INTS10 CSGALNACT1 LOC105379312 GC08M020154
GH08F020206 0.4 FANTOM5 10.7 -23.5 -23500 0.3 ATP6V1B2 RNU6-892P SLC18A1 LZTS1 GC08P020230
GH08F019965 0.2 ENCODE 10.6 +217.9 217890 0.7 SLC18A1 LPL GC08M019958 LOC105379311
GH08F019962 0.9 Ensembl ENCODE 10.6 +220.9 220870 0.7 ZNF316 MAFF ZNF512 EMSY MAFK SPI1 SLC18A1 GC08M019958 LOC105379311
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC18A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC18A1 Gene

Chromosome:
8
Start:
20,144,855 bp from pter
End:
20,183,338 bp from pter
Size:
38,484 bases
Orientation:
Minus strand

Genomic View for SLC18A1 Gene

Genes around SLC18A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC18A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC18A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC18A1 Gene

Proteins for SLC18A1 Gene

  • Protein details for SLC18A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54219-VMAT1_HUMAN
    Recommended name:
    Chromaffin granule amine transporter
    Protein Accession:
    P54219
    Secondary Accessions:
    • E9PDJ5
    • Q9BRE4

    Protein attributes for SLC18A1 Gene

    Size:
    525 amino acids
    Molecular mass:
    56257 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC18A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC18A1 Gene

Post-translational modifications for SLC18A1 Gene

  • Glycosylation at Asn 58, Asn 87, and Asn 104
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC18A1 Gene

Domains & Families for SLC18A1 Gene

Gene Families for SLC18A1 Gene

Protein Domains for SLC18A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC18A1 Gene

Graphical View of Domain Structure for InterPro Entry

P54219

UniProtKB/Swiss-Prot:

VMAT1_HUMAN :
  • Belongs to the major facilitator superfamily. Vesicular transporter family.
Family:
  • Belongs to the major facilitator superfamily. Vesicular transporter family.
genes like me logo Genes that share domains with SLC18A1: view

Function for SLC18A1 Gene

Molecular function for SLC18A1 Gene

GENATLAS Biochemistry:
solute carrier family 18,member A1,vesicular monoamine transporter,expressed in adrenals
UniProtKB/Swiss-Prot Function:
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.

Gene Ontology (GO) - Molecular Function for SLC18A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008504 monoamine transmembrane transporter activity TAS 8643547
GO:0015222 serotonin transmembrane transporter activity IBA --
GO:0015238 drug transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC18A1: view
genes like me logo Genes that share phenotypes with SLC18A1: view

Animal Models for SLC18A1 Gene

MGI Knock Outs for SLC18A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC18A1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC18A1 Gene

Localization for SLC18A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC18A1 Gene

Isoform 1: Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC18A1 Gene COMPARTMENTS Subcellular localization image for SLC18A1 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SLC18A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SLC18A1: view

Pathways & Interactions for SLC18A1 Gene

genes like me logo Genes that share pathways with SLC18A1: view

Interacting Proteins for SLC18A1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000276373%0d%0a9606.ENSP00000249396%0d%0a9606.ENSP00000212015%0d%0a9606.ENSP00000270349%0d%0a9606.ENSP00000219833%0d%0a9606.ENSP00000261707%0d%0a
Selected Interacting proteins: ENSP00000276373 P54219-VMAT1_HUMAN for SLC18A1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC18A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport IEA --
GO:0006837 serotonin transport IEA --
GO:0006855 drug transmembrane transport IEA --
GO:0007268 chemical synaptic transmission IBA --
genes like me logo Genes that share ontologies with SLC18A1: view

No data available for SIGNOR curated interactions for SLC18A1 Gene

Drugs & Compounds for SLC18A1 Gene

(11) Drugs for SLC18A1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methamphetamine Approved, Illicit Pharma antagonist, Target, inhibitor 232
Reserpine Approved Pharma Inhibition, Inhibitor, blocker, Target 7
Tetrabenazine Approved Pharma Inhibition, Inhibitor, blocker Potent inhibitor of vesicular monoamine transport 16
Norepinephrine Approved Pharma Target, binder 683
Ephedra Approved, Withdrawn Nutra Target, inhibitor 2

(3) Additional Compounds for SLC18A1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FFN 206 dihydrochloride
FFN 511
1004548-96-2

(3) Tocris Compounds for SLC18A1 Gene

Compound Action Cas Number
FFN 206 dihydrochloride Fluorescent VMAT2 substrate
FFN 511 Fluorescent substrate for VMAT2 1004548-96-2
Rose Bengal Potent VGlut and VMAT inhibitor; cell permeable 632-69-9

(1) ApexBio Compounds for SLC18A1 Gene

Compound Action Cas Number
Rose Bengal VGlut and vesicular monoamine transporter (VMAT) inhibitor 632-69-9
genes like me logo Genes that share compounds with SLC18A1: view

Transcripts for SLC18A1 Gene

Unigene Clusters for SLC18A1 Gene

Solute carrier family 18 (vesicular monoamine), member 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC18A1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6: - -

Relevant External Links for SLC18A1 Gene

GeneLoc Exon Structure for
SLC18A1
ECgene alternative splicing isoforms for
SLC18A1

Expression for SLC18A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC18A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC18A1 Gene

This gene is overexpressed in Adrenal Gland (x16.9), Brain - Substantia nigra (x7.8), and Small Intestine - Terminal Ileum (x5.1).

Protein differential expression in normal tissues from HIPED for SLC18A1 Gene

This gene is overexpressed in Adrenal (56.6) and Testis (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC18A1 Gene



Protein tissue co-expression partners for SLC18A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC18A1 Gene:

SLC18A1

SOURCE GeneReport for Unigene cluster for SLC18A1 Gene:

Hs.158322
genes like me logo Genes that share expression patterns with SLC18A1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC18A1 Gene

Orthologs for SLC18A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC18A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC18A1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC18A1 34 35
  • 87.15 (n)
dog
(Canis familiaris)
Mammalia SLC18A1 34 35
  • 86.7 (n)
mouse
(Mus musculus)
Mammalia Slc18a1 34 16 35
  • 84.07 (n)
rat
(Rattus norvegicus)
Mammalia Slc18a1 34
  • 83.69 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC18A1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC18A1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC18A1 34 35
  • 71.54 (n)
lizard
(Anolis carolinensis)
Reptilia SLC18A1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487393 34
  • 65.28 (n)
Str.2504 34
zebrafish
(Danio rerio)
Actinopterygii LOC100331899 34
  • 66.14 (n)
SLC18A1 35
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6119 36
  • 63 (a)
Vmat 35
  • 41 (a)
OneToMany
CG10251 36
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea cat-1 36 35
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for SLC18A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC18A1 Gene

ENSEMBL:
Gene Tree for SLC18A1 (if available)
TreeFam:
Gene Tree for SLC18A1 (if available)

Paralogs for SLC18A1 Gene

Paralogs for SLC18A1 Gene

(3) SIMAP similar genes for SLC18A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC18A1: view

Variants for SLC18A1 Gene

Sequence variations from dbSNP and Humsavar for SLC18A1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10094232 -- 20,173,485(+) GCACA(A/C)AGAGA intron-variant
rs10095858 -- 20,170,814(+) ATACA(C/T)ACCCC intron-variant
rs10102445 -- 20,170,551(+) GAGCT(A/G/T)TTTTT intron-variant
rs10102779 -- 20,147,928(+) TCTGA(G/T)GAGAA intron-variant
rs10108611 -- 20,173,486(+) CACAC(A/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC18A1 Gene

Variant ID Type Subtype PubMed ID
esv2675168 CNV deletion 23128226
esv2759602 CNV loss 17122850
esv3616559 CNV loss 21293372
esv3616560 CNV gain 21293372
esv3616561 CNV loss 21293372
esv3616562 CNV loss 21293372
esv3891373 CNV loss 25118596
nsv1030738 CNV gain 25217958
nsv1033511 CNV gain 25217958
nsv438045 CNV loss 16468122
nsv508498 CNV deletion 20534489
nsv522185 CNV gain 19592680
nsv610759 CNV gain 21841781
nsv824563 CNV loss 20364138
nsv8312 CNV gain 18304495

Variation tolerance for SLC18A1 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC18A1 Gene

Human Gene Mutation Database (HGMD)
SLC18A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC18A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC18A1 Gene

Disorders for SLC18A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC18A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
paranoid schizophrenia
  • chronic paranoid schizophrenia
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC18A1

Genetic Association Database (GAD)
SLC18A1
Human Genome Epidemiology (HuGE) Navigator
SLC18A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC18A1
genes like me logo Genes that share disorders with SLC18A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC18A1 Gene

Publications for SLC18A1 Gene

  1. Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits. (PMID: 18249496) Lohoff F.W. … Gallinat J. (Neurosci. Lett. 2008) 3 22 46 64
  2. Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia. (PMID: 18451639) Lohoff F.W. … Berrettini W.H. (Neuropsychobiology 2008) 3 22 46 64
  3. Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. (PMID: 16936705) Lohoff F.W. … Berrettini W.H. (Neuropsychopharmacology 2006) 3 22 46 64
  4. Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population. (PMID: 17134514) Richards M. … Kunugi H. (Behav Brain Funct 2006) 3 22 46 64
  5. Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1. (PMID: 16326835) Essand M. … Giandomenico V. (J. Mol. Endocrinol. 2005) 3 4 22 64

Products for SLC18A1 Gene

Sources for SLC18A1 Gene

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