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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC17A9 Gene

protein-coding   GIFtS: 45
GCID: GC20P061583

solute carrier family 17, member 9

(Previous name: chromosome 20 open reading frame 59 )
(Previous symbol: C20orf59)
 Explore 1 disease affiliated with
SLC17A9 via our new
 Human Malady Compendium 
Biological research products
for SLC17A9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 17, Member 91 2
C20orf591 2 3 5
FLJ234121
Chromosome 20 Open Reading Frame 591
Solute Carrier Family 17 Member 92
Vesicular Nucleotide Transporter SLC17A92

External Ids:    HGNC: 161921   Entrez Gene: 639102   Ensembl: ENSG000001011947   OMIM: 6121075   UniProtKB: Q9BYT13   

Export aliases for SLC17A9 gene to outside databases

Previous GC identifers: GC20P061055 GC20P058301


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S17A9_HUMAN, Q9BYT1
Function: Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory
vesicles such as adrenal chromaffin granules and synaptic vesicles




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011333.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC17A9 gene promoter:
         MyoD   CUTL1   XBP-1   Arnt   Pax-3   CP2   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC17A9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

SLC17A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A9 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061583:  view genomic region     (about GC identifiers)

Start:
61,583,999 bp from pter      End:
61,599,949 bp from pter
Size:
15,951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S17A9_HUMAN, Q9BYT1 (See protein sequence)
Recommended Name: Solute carrier family 17 member 9  
Size: 436 amino acids; 47482 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH25312.1; Type=Erroneous termination; Positions=389; Note=Translated as Leu;
Sequence=BAB84933.1; Type=Erroneous initiation;
Secondary accessions: B3KTF2 Q5W198 Q8TB07 Q8TBP4 Q8TEL5 Q9BYT0 Q9BYT2
Alternative splicing: 3 isoforms:  Q9BYT1-1   Q9BYT1-2   Q9BYT1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC17A9: NX_Q9BYT1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYT1

  • SLC17A9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_071365.3  
    ENSEMBL proteins: 
     ENSP00000359376   ENSP00000359374   ENSP00000388215  

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    Uscn Proteins for SLC17A9

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    SLC17A9 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC17A9 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR005829 Sugar_transporter_CS
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9BYT1

    ProtoNet protein and cluster: Q9BYT1

    UniProtKB/Swiss-Prot: S17A9_HUMAN, Q9BYT1
    Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: S17A9_HUMAN, Q9BYT1
    Function: Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory
    vesicles such as adrenal chromaffin granules and synaptic vesicles

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    hsa-miR-633 hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A9 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--


    SLC17A9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC17A9:
     Decreased POU5F1-GFP protein e 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc17a9):
     normal 

    SLC17A9 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC17A9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC17A9 (ENSP000003593764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPA2ENSP000003630214STRING: ENSP00000363021
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0055085transmembrane transport IEA--


    SLC17A9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC17A9
    Search CenterWatch for drugs/clinical trials and news about SLC17A9 / S17A9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC17A9 gene: 
    NM_022082.3  

    Unigene Cluster for SLC17A9:

    Solute carrier family 17, member 9
    Hs.512686  [show with all ESTs]
    Unigene Representative Sequence: NM_022082
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370351(uc002yea.4) ENST00000370349(uc002ydz.4) ENST00000488738(uc011aap.1)
    ENST00000411611 ENST00000459704 ENST00000487303 ENST00000483113

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC17A9:
    hsa-miR-633 hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A9 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK027065.1 AK095473.1 AK298503.1 BC025312.1 BC027447.1 BC038593.1 

    10 DOTS entries:

    DT.95238481  DT.100751878  DT.445986  DT.100774410  DT.101980055  DT.95087816  DT.120808017  DT.100774411 
    DT.91942790  DT.95243379 

    24/92 AceView cDNA sequences (see all 92):

    BM853100 AA857559 AI581650 AW292227 AI744671 AW007867 BX089422 BU158616 
    BC038593 AA342761 BM745475 BG028021 BM825045 AI808824 AA873053 BI754946 
    BM740993 BF108812 R91709 BE676338 BX399846 BI521634 BE244046 AA599206 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A9 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -                       -                 -                             -           -                                 
    SP2:              -     -                 -                 -                             -           -                                 
    SP3:              -                       -                 -                             -           -                                 
    SP4:              -     -                 -                 -                                         -                                 
    SP5:                                                                    -                 -           -                                 


    ECgene alternative splicing isoforms for SLC17A9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC17A9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTAATGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SLC17A9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC17A9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC17A9

    SOURCE GeneReport for Unigene cluster: Hs.512686

    UniProtKB/Swiss-Prot: S17A9_HUMAN, Q9BYT1
    Tissue specificity: Predominantly expressed in adrenal gland, brain and thyroid

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC17A9 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC17A91 solute carrier family 17, member 9 74.35(n)
    70.05(a)
      419236  NM_001006292.1  NP_001006292.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC17A96
    --
    68(a)
    1 ↔ 1
    4(152626328-152642732)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92202 Xenopus laevis transcribed sequence with weak similarity more 73.45(n)    BX842852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb8492 sbcb849 72.68(n)   386788  CK028379.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154381 CG15438 51.74(n)
    40.19(a)
      33650  NM_134991.2  NP_608835.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vnut-11 Protein VNUT-1 48.3(n)
    40.94(a)
      175106  NM_064606.3  NP_497007.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ANTR26
    PHT4;26
    (see all 5)
    putative anion transporter 3
    (see all 5)
    23(a)
    23(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    4(162897-166357)
    2(15922557-15925623)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 5)
    sialin, putative, expressed
    transporter, major facilitator family, putative, e...
    (see all 5)
    28(a)
    24(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    9(22106871-22111218)
    1(9912366-9916294)


    ENSEMBL Gene Tree for SLC17A9 (if available)
    TreeFam Gene Tree for SLC17A9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC17A9 gene
    SLC17A72  SLC17A82  SLC17A62  SLC17A32  SLC17A12  SLC17A42  SLC17A52  SLC17A22  
    2 SIMAP similar genes for SLC17A9 using alignment to 2 protein entries:     S17A9_HUMAN (see all proteins):
    C20orf59    SLC17A5

    SLC17A9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/383 NCBI SNPs in SLC17A9 are shown (see all 383    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562898361,2
    C--58314366(+) TGGGGC/TTCGGG 1 -- int10--------
    rs60901771,2
    F,A--58314377(+) TTGGCA/GTGGTG 1 -- int12Minor allele frequency- G:0.40NA CSA 5
    rs557015001,2
    C--58314402(+) GCTCTA/GGCCAG 1 -- int10--------
    rs622006651,2
    --61582006(+) GACTGG/TGTTAG 1 -- us2k12Minor allele frequency- T:0.03NA 122
    rs1915336511,2
    --61582055(+) CGCACA/GTGATG 1 -- us2k10--------
    rs1825144241,2
    --61582073(+) CCGCGC/GTCTTC 1 -- us2k10--------
    rs22558171,2
    C,F,A,H,--61582138(-) TCCATA/GAAAAG 1 -- us2k1 trp320Minor allele frequency- G:0.32EA NS NA WA CSA 1889
    rs739188791,2
    C,--61582274(+) GTCTGT/GGGGGG 1 -- us2k12Minor allele frequency- G:0.04WA 120
    rs1868003751,2
    --61582314(+) CCATAC/TGTAGT 1 -- us2k10--------
    rs766491691,2
    C,F,--61582424(+) GGCACG/ACAGCC 1 -- us2k12Minor allele frequency- A:0.04NA EA 240

    HapMap Linkage Disequilibrium report for SLC17A9 (61583999 - 61599949 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SLC17A9
         2 CNVs: 31044 5145
         2 Indels: 26888 73565

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC17A9
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC17A9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC17A9 for disorders           About GeneDecksing

    OMIM gene information: 612107    OMIM disorders: --

    1 disease for SLC17A9:    About MalaCards
    thyroiditis


    Export disorders for SLC17A9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC17A9 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC17A9)
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    1. Identification of a vesicular nucleotide transporter. (PubMed id 18375752)1, 2, 3 Sawada K.... Moriyama Y. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (2003)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Regulation of purinergic signaling in biliary epithel ial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles. (PubMed id 21613220)1 Sathe M.N....Feranchak A.P. (2011)
    7. Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation. (PubMed id 20382737)1 Tokunaga A....Kojima S. (2010)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63910 HGNC: 16192 AceView: C20orf59 Ensembl:ENSG00000101194 euGenes: HUgn63910
    ECgene: SLC17A9 H-InvDB: SLC17A9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC17A9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC17A9 gene:
    Search GeneIP for patents involving SLC17A9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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