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Aliases for SLC17A8 Gene

Aliases for SLC17A8 Gene

  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 8 2 3
  • VGLUT3 3 4 6
  • Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 8 2 3
  • Vesicular Glutamate Transporter 3 2 3
  • Solute Carrier Family 17 Member 8 3 4
  • DFNA25 3 6
  • Deafness, Autosomal Dominant 25 2

External Ids for SLC17A8 Gene

Previous HGNC Symbols for SLC17A8 Gene

  • DFNA25

Previous GeneCards Identifiers for SLC17A8 Gene

  • GC12P100683
  • GC12P099253
  • GC12P097811
  • GC12P100750

Summaries for SLC17A8 Gene

Entrez Gene Summary for SLC17A8 Gene

  • This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for SLC17A8 Gene

SLC17A8 (Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 8) is a Protein Coding gene. Diseases associated with SLC17A8 include deafness, autosomal dominant 25 and dfna25 nonsyndromic hearing loss and deafness. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include symporter activity and L-glutamate transmembrane transporter activity. An important paralog of this gene is SLC17A3.

UniProtKB/Swiss-Prot for SLC17A8 Gene

  • Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Wiki entry for SLC17A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A8 Gene

Genomics for SLC17A8 Gene

Regulatory Elements for SLC17A8 Gene

Genomic Location for SLC17A8 Gene

100,357,079 bp from pter
100,422,059 bp from pter
64,981 bases
Plus strand

Genomic View for SLC17A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC17A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A8 Gene

Proteins for SLC17A8 Gene

  • Protein details for SLC17A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicular glutamate transporter 3
    Protein Accession:
    Secondary Accessions:
    • B3KXZ6
    • B7ZKV4
    • Q17RQ8

    Protein attributes for SLC17A8 Gene

    589 amino acids
    Molecular mass:
    64991 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC17A8 Gene


neXtProt entry for SLC17A8 Gene

Proteomics data for SLC17A8 Gene at MOPED

Post-translational modifications for SLC17A8 Gene

Other Protein References for SLC17A8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC17A8

No data available for DME Specific Peptides for SLC17A8 Gene

Domains for SLC17A8 Gene

Gene Families for SLC17A8 Gene

Protein Domains for SLC17A8 Gene


Suggested Antigen Peptide Sequences for SLC17A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
genes like me logo Genes that share domains with SLC17A8: view

Function for SLC17A8 Gene

Molecular function for SLC17A8 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Ontology (GO) - Molecular Function for SLC17A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC17A8: view
genes like me logo Genes that share phenotypes with SLC17A8: view

Animal Models for SLC17A8 Gene

MGI Knock Outs for SLC17A8:

Animal Model Products

CRISPR Products

miRNA for SLC17A8 Gene

miRTarBase miRNAs that target SLC17A8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC17A8 Gene

Localization for SLC17A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A8 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

Jensen Localization Image for SLC17A8 Gene COMPARTMENTS Subcellular localization image for SLC17A8 gene
Compartment Confidence
plasma membrane 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC17A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane TAS --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with SLC17A8: view

Pathways for SLC17A8 Gene

genes like me logo Genes that share pathways with SLC17A8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC17A8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000316909 for SLC17A8 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC17A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006836 neurotransmitter transport IEA --
GO:0007605 sensory perception of sound IEA --
GO:0015813 L-glutamate transport --
genes like me logo Genes that share ontologies with SLC17A8: view

Compounds for SLC17A8 Gene

(1) HMDB Compounds for SLC17A8 Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium

(1) Novoseek inferred chemical compound relationships for SLC17A8 Gene

Compound -log(P) Hits PubMed IDs
glutamate 58.4 11
genes like me logo Genes that share compounds with SLC17A8: view

Transcripts for SLC17A8 Gene

mRNA/cDNA for SLC17A8 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC17A8 Gene

Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A8 Gene

No ASD Table

Relevant External Links for SLC17A8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC17A8 Gene

mRNA expression in normal human tissues for SLC17A8 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A8 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (13.9), Brain - Caudate (basal ganglia) (5.4), Brain - Amygdala (4.6), Brain - Putamen (basal ganglia) (4.1), and Brain - Hippocampus (4.0).

Protein differential expression in normal tissues for SLC17A8 Gene

This gene is overexpressed in Heart (37.1) and CD4 Tcells (31.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC17A8 Gene

SOURCE GeneReport for Unigene cluster for SLC17A8 Gene Hs.116871

mRNA Expression by UniProt/SwissProt for SLC17A8 Gene

Tissue specificity: Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.
genes like me logo Genes that share expressions with SLC17A8: view

Expression partners for SLC17A8 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC17A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC17A8 35
  • 91.5 (n)
  • 94.05 (a)
SLC17A8 36
  • 94 (a)
(Canis familiaris)
Mammalia SLC17A8 35
  • 91.42 (n)
  • 93.96 (a)
SLC17A8 36
  • 91 (a)
(Mus musculus)
Mammalia Slc17a8 35
  • 87.81 (n)
  • 92.69 (a)
Slc17a8 16
Slc17a8 36
  • 91 (a)
(Pan troglodytes)
Mammalia SLC17A8 35
  • 99.04 (n)
  • 99.32 (a)
SLC17A8 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc17a8 35
  • 88.38 (n)
  • 92.35 (a)
(Monodelphis domestica)
Mammalia SLC17A8 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia SLC17A8 36
  • 91 (a)
(Gallus gallus)
Aves SLC17A8 35
  • 78.31 (n)
  • 85.86 (a)
SLC17A8 36
  • 86 (a)
(Anolis carolinensis)
Reptilia SLC17A8 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc17a8 35
  • 75.09 (n)
  • 81.57 (a)
(Danio rerio)
Actinopterygii slc17a8 35
  • 71.79 (n)
  • 79.62 (a)
slc17a8 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta VGlut 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea eat-4 36
  • 45 (a)
vglu-2 36
  • 35 (a)
vglu-3 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
Species with no ortholog for SLC17A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC17A8 Gene

Gene Tree for SLC17A8 (if available)
Gene Tree for SLC17A8 (if available)

Paralogs for SLC17A8 Gene

Paralogs for SLC17A8 Gene

(6) SIMAP similar genes for SLC17A8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC17A8: view

Variants for SLC17A8 Gene

Sequence variations from dbSNP and Humsavar for SLC17A8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs943402 -- 100,399,201(-) TATGC(A/G)AAGAA intron-variant
rs943403 -- 100,380,391(+) AAATG(A/G)CATGA intron-variant
rs1536463 -- 100,389,608(-) TCTCt(A/C)tatat intron-variant
rs1806917 -- 100,374,469(-) ACGCC(C/T)GGCTA intron-variant
rs1834880 -- 100,362,564(+) CAACC(A/G)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A8 Gene

Variant ID Type Subtype PubMed ID
nsv851 CNV Loss 18451855
esv988196 CNV Deletion 20482838

Relevant External Links for SLC17A8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A8 Gene

Disorders for SLC17A8 Gene

(1) OMIM Diseases for SLC17A8 Gene (607557)


  • Deafness, autosomal dominant, 25 (DFNA25) [MIM:605583]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA25 expression is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged. {ECO:0000269 PubMed:18674745}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC17A8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC17A8: view

No data available for Novoseek inferred disease relationships and Genatlas for SLC17A8 Gene

Publications for SLC17A8 Gene

  1. Molecular cloning and functional characterization of human vesicular glutamate transporter 3. (PMID: 12151341) Takamori S. … Jahn R. (EMBO Rep. 2002) 2 3 4 23
  2. Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. (PMID: 18674745) Ruel J. … Puel J.-L. (Am. J. Hum. Genet. 2008) 3 4 23
  3. The diverse roles of vesicular glutamate transporter 3. (PMID: 16722234) Seal R.P. … Edwards R.H. (Handb Exp Pharmacol 2006) 3 23
  4. Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons. (PMID: 16738232) Manent J.B. … Represa A. (J. Neurosci. 2006) 23
  5. Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum. (PMID: 18611437) Riedel A. … HAortig W. (J. Chem. Neuroanat. 2008) 23

Products for SLC17A8 Gene

Sources for SLC17A8 Gene

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