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SLC17A7 Gene

protein-coding   GIFtS: 61
GCID: GC19M049934

Solute Carrier Family 17 (Vesicular Glutamate Transporter),...

(Previous names: solute carrier family 17 (sodium-dependent inorganic phosphate...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member
71 2
     Brain-Specific Na(+)-Dependent Inorganic Phosphate Cotransporter2 3
BNPI2 3 5     Solute Carrier Family 17 Member 72 3
VGLUT12 3 5     Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter2
Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate
Cotransporter), Member 71 2
     VGluT13
Vesicular Glutamate Transporter 11 2     

External Ids:    HGNC: 167041   Entrez Gene: 570302   Ensembl: ENSG000001048887   OMIM: 6052085   UniProtKB: Q9P2U73   

Export aliases for SLC17A7 gene to outside databases

Previous GC identifers: GC19M050591 GC19M050301 GC19M054608 GC19M054624 GC19M049933 GC19M046309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC17A7 Gene:
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically
expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic
vesicles and functions in glutamate transport. The protein shares 82% identity with the
differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct
class within the Na+/Pi cotransporter family. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC17A7 Gene:
SLC17A7 (solute carrier family 17 (vesicular glutamate transporter), member 7) is a protein-coding gene. Diseases associated with SLC17A7 include febrile seizures, and nicotine addiction. GO annotations related to this gene include inorganic phosphate transmembrane transporter activity and L-glutamate transmembrane transporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7
Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory
neural cells. May also mediate the transport of inorganic phosphate

Gene Wiki entry for SLC17A7 (Vesicular glutamate transporter 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC17A7 gene promoter:
         C/EBPbeta   Pax-5   Pax-2   Tal-1beta   E47   MZF-1   Pax-2b   HOXA5   ITF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC17A7 promoter sequence
   Search Chromatin IP Primers for SLC17A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC17A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

SLC17A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049934:  view genomic region     (about GC identifiers)

Start:
49,932,655 bp from pter      End:
49,945,617 bp from pter
Size:
12,963 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7 (See protein sequence)
Recommended Name: Vesicular glutamate transporter 1  
Size: 560 amino acids; 61613 Da
Subunit: Interacts with SHANK3 (By similarity)
Secondary accessions: Q6PCD0

Explore the universe of human proteins at neXtProt for SLC17A7: NX_Q9P2U7

Explore proteomics data for SLC17A7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC17A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064705.1  
    ENSEMBL proteins: 
     ENSP00000221485   ENSP00000470338   ENSP00000472086   ENSP00000441767  
    Reactome Protein details: Q9P2U7

    SLC17A7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Vesicular glutamate transporter 1
    Vesicular glutamate transporters (VGLUTs)

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9P2U7

    ProtoNet protein and cluster: Q9P2U7

    UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7
    Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily


    SLC17A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VGLU1_HUMAN, Q9P2U7
    Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory
    neural cells. May also mediate the transport of inorganic phosphate

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005313L-glutamate transmembrane transporter activity TAS--
    GO:0005315inorganic phosphate transmembrane transporter activity IEA--
    GO:0015319sodium:inorganic phosphate symporter activity IDA10820226
    GO:0015321sodium-dependent phosphate transmembrane transporter activity IEA--
         
    SLC17A7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC17A7:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Slc17a7):
     behavior/neurological  growth/size/body  integument  mortality/aging  nervous system 
     normal  vision/eye 

    SLC17A7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC17A7: Slc17a7tm1Edw Slc17a7tm1Rmnd Slc17a7tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC17A7
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC17A7 (see all 61):
    hsa-miR-194* hsa-miR-3164 hsa-miR-142-5p hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-486-3p hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VGLU1_HUMAN, Q9P2U7: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane;
    Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008021synaptic vesicle ----
    GO:0016021integral component of membrane IDA10820226
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane TAS--

    SLC17A7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC17A7 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Organic anion transporters0.00
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    4Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    Glutamatergic synapse0.39
    5Neurotransmitter Release Cycle
    Neurotransmitter Release Cycle0.32
    Glutamate Neurotransmitter Release Cycle0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SLC17A7
        Neuroscience

    1 BioSystems Pathway for SLC17A7
        Synaptic Vesicle Pathway

    2 Reactome Pathways for SLC17A7
        Glutamate Neurotransmitter Release Cycle
    Organic anion transporters


    4 Kegg Pathways  (Kegg details for SLC17A7):
        Synaptic vesicle cycle
    Retrograde endocannabinoid signaling
    Glutamatergic synapse
    Nicotine addiction


    SLC17A7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC17A7: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC17A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SLC17A7 (Q9P2U73 ENSP000002214854) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL2Q999623, ENSP000003699814I2D: score=2 STRING: ENSP00000369981
    CPLX1ENSP000003056134STRING: ENSP00000305613
    RAB3AENSP000002222564STRING: ENSP00000222256
    RIMS1ENSP000002648394STRING: ENSP00000264839
    SYT1ENSP000002612054STRING: ENSP00000261205
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006817phosphate ion transport TAS8632143
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007616long-term memory IEA--

    SLC17A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC17A7 (VGLU1)

    1 HMDB Compound for SLC17A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    5 Novoseek inferred chemical compound relationships for SLC17A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 79.4 129 15961236 (8), 17581970 (5), 11985876 (3), 11698620 (3) (see all 57)
    gaba 48.9 16 11698620 (2), 16546297 (2), 17503488 (1), 17623043 (1) (see all 7)
    methamphetamine 24.8 4 17581970 (3)
    nmda 7.68 3 15384067 (1), 17596438 (1)
    chloride 1.48 2 10938000 (1), 12444014 (1)



    SLC17A7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC17A7 gene: 
    NM_020309.3  

    Unigene Cluster for SLC17A7:

    Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
    Hs.375616  [show with all ESTs]
    Unigene Representative Sequence: NM_020309
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221485(uc002pno.3 uc002pnp.3) ENST00000600601 ENST00000600672
    ENST00000596689 ENST00000598018 ENST00000543531(uc002pnq.1)

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    hsa-miR-194* hsa-miR-3164 hsa-miR-142-5p hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-486-3p hsa-miR-488
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    Additional mRNA sequence: 

    AB032436.1 AK091061.1 AK095659.2 AK289622.1 AK294226.1 AK294405.1 BC059379.1 

    8 DOTS entries:

    DT.97785527  DT.92426144  DT.86851874  DT.97785140  DT.97786220  DT.97791534  DT.121419286  DT.91666041 

    Selected AceView cDNA sequences (see all 106):

    BM708393 CB153243 BQ636968 AX746758 AI198224 AB032436 NM_020309 BF960075 
    AL119539 BM920768 R13975 CB117584 CB153176 BM672805 BM544770 CB117557 
    BX477970 AL157531 AK091061 AW594475 BE892556 AK095659 AI351148 BM693490 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A7    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:              -                                                     -     -                                                   
    SP2:                                                                    -                             -                           
    SP3:                                                                                                                              
    SP4:                                                                    -     -                 -                                 
    SP5:        -     -                                                                                                               


    ECgene alternative splicing isoforms for SLC17A7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SLC17A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGGAATG
    SLC17A7 Expression
    About this image


    SLC17A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Cerebral Cortex
             Globus Pallidus   
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
    SLC17A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC17A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375616

    UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7
    Tissue specificity: Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex,
    hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC17A7: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              GABA & Glutamate in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC17A7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc17a71 , 5 solute carrier family 17 (sodium-dependent inorganic more1, 5 90.24(n)1
    98.57(a)1
      7 (29.16 cM)5
    729611  NM_182993.21  NP_892038.21 
     451639215 
    lizard
    (Anolis carolinensis)
    Reptilia SLC17A76
    solute carrier family 17 (vesicular glutamate tran...
    81(a)
    1 ↔ 1
    GL343355.1(400983-460683)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc17a71 solute carrier family 17 (vesicular glutamate transporter), more 73.26(n)
    85.21(a)
      780064  NM_001079140.1  NP_001072608.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc17a71 solute carrier family 17 (sodium-dependent inorganic more 73.05(n)
    84.48(a)
      795293  NM_001098755.1  NP_001092225.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98873 high affinity inorganic
    phosphate:sodium symporter
    48(a)
    (best of 20)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea T07A5.33
    eat-41
    sodium/phosphate transporter protein3
    eat-41
    43(a)
    (best of 9)3
    51.8(n)1
    50.92(a)1
      III(10372084-10374948)3
    1762911  NM_066622.41  NP_499023.31 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PHT4;11 PHT4;1 45.85(n)
    37.56(a)
      817515  NM_128519.5  NP_180526.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02797001 Os01g0279700 46.49(n)
    37.75(a)
      4326905  NM_001049284.1  NP_001042749.1 


    ENSEMBL Gene Tree for SLC17A7 (if available)
    TreeFam Gene Tree for SLC17A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SLC17A7 gene
    SLC17A82  SLC17A62  SLC17A32  SLC17A42  SLC17A12  SLC17A52  SLC17A92  SLC17A22  
    8 SIMAP similar genes for SLC17A7 using alignment to 5 protein entries:     VGLU1_HUMAN (see all proteins):
    SLC17A6    SLC17A8    SLC17A5    SLC17A4    SLC17A1    SLC17A2
    SLC17A3    C20orf59

    SLC17A7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SLC17A7 (see all 350)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488937801,2
    Cuntested149937875(+) GTCGTC/TGCCAG 2 A syn10--------
    rs1848164251,2
    --49932608(+) GAGGAC/TGGGGC 1 -- ds50010--------
    rs1901960221,2
    C--49932611(+) GACGGA/GGCTGG 1 -- ds50010--------
    rs1114744391,2
    C--49932657(+) AACTGT/AGCCTA 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs789361891,2
    C--49932723(+) AGAGAC/TACAAA 1 -- ut310--------
    rs10435581,2
    C,F,A,H--49932762(-) AGGAGA/CCAGGG 1 -- ut3125Minor allele frequency- C:0.27MN NS EA NA WA CSA 2537
    rs1499074621,2
    C--49932898(+) CAAATA/GGCCAC 1 -- ut310--------
    rs105829031,2
    C--49933055(+) GAAAA-/CCATGTC 1 -- ut310--------
    rs1448683551,2
    C--49933058(+) AACCAG/TGTCAG 1 -- ut310--------
    rs1490388271,2
    --49933070(+) AAAAGC/TGCACG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC17A7 (49932655 - 49945617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC17A7:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv52n68CNV Loss17160897
    nsv912262CNV Loss21882294
    nsv912264CNV Loss21882294
    nsv912261CNV Loss21882294
    nsv912263CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC17A7
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC17A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605208    OMIM disorders: --

    13 diseases for SLC17A7:    
    About MalaCards
    febrile seizures    nicotine addiction    major depressive disorder    schizophrenia
    bipolar disorder    cholera    neuronitis    parkinson's disease
    cerebritis    alzheimer's disease    retinitis    cervicitis
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for SLC17A7:
    Schizophrenia     Cholera

    SLC17A7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for SLC17A7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 28.4 14 19720501 (3), 15653259 (2), 11588596 (2), 17371293 (1) (see all 6)
    epilepsy 3.35 2 15961236 (1), 16083865 (1), 17711980 (1)

    Genetic Association Database (GAD): SLC17A7
    Human Genome Epidemiology (HuGE) Navigator: SLC17A7 (3 documents)

    Export disorders for SLC17A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC17A7 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with SLC17A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 10820226)1, 2, 3, 9 Aihara Y.... Takeda J. (J. Neurochem. 2000)
    2. Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia. (PubMed id 19720501)1, 4, 9 Shen Y.C....Chen C.H. (Schizophr. Res. 2009)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    5. Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 8632143)1, 3 Ni B....Paul S.M. (J. Neurochem. 1996)
    6. Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex. (PubMed id 15961236)1, 9 Alonso-Nanclares L. and De Felipe J. (Neuroscience 2005)
    7. Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. (PubMed id 17531353)1, 9 Kashani A....El Mestikawy S. (Neurobiol. Aging 2008)
    8. Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. (PubMed id 15653259)1, 9 Eastwood S.L. and Harrison P.J. (Schizophr. Res. 2005)
    9. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. (PubMed id 11001057)1, 9 Takamori S....Jahn R. (Nature 2000)
    10. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. (PubMed id 10938000)1, 9 Bellocchio E.E....Edwards R.H. (Science 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57030 HGNC: 16704 AceView: SLC17A7 Ensembl:ENSG00000104888 euGenes: HUgn57030
    ECgene: SLC17A7 Kegg: 57030 H-InvDB: SLC17A7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC17A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC17A7 gene:
    Search GeneIP for patents involving SLC17A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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