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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC17A7 Gene

protein-coding   GIFtS: 60
GCID: GC19M049933

solute carrier family 17 (sodium-dependent inorganic phosphate...
 Explore 13 diseases affiliated with
SLC17A7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC17A7    

Aliases
for SLC17A7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate
Cotransporter), Member 71 2
     Solute Carrier Family 17 Member 72 3
BNPI1 2 3 5     Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter2
VGLUT11 2 3 5     Vesicular Glutamate Transporter 12
Brain-Specific Na(+)-Dependent Inorganic Phosphate Cotransporter2 3     VGluT13

External Ids:    HGNC: 167041   Entrez Gene: 570302   Ensembl: ENSG000001048887   OMIM: 6052085   UniProtKB: Q9P2U73   

Export aliases for SLC17A7 gene to outside databases

Previous GC identifers: GC19M050591 GC19M050301 GC19M054608 GC19M054624 GC19M046309


Summaries
for SLC17A7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC17A7:
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically
expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic
vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated
Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi
cotransporter family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7
Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural
cells. May also mediate the transport of inorganic phosphate

Gene Wiki entry for SLC17A7 (Vesicular glutamate transporter 1)


Genomic Views
for SLC17A7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC17A7 gene promoter:
         C/EBPbeta   Pax-5   Pax-2   Tal-1beta   E47   MZF-1   Pax-2b   HOXA5   ITF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC17A7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC17A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

SLC17A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049933:  view genomic region     (about GC identifiers)

Start:
 49,932,655 bp from pter      End:
 49,945,617 bp from pter
Size:
 12,963 bases      Orientation:
 minus strand

Proteins
for SLC17A7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7 (See protein sequence)
Recommended Name: Vesicular glutamate transporter 1  
Size: 560 amino acids; 61613 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane;
Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity)
Secondary accessions: Q6PCD0

Explore the universe of human proteins at neXtProt for SLC17A7: NX_Q9P2U7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2U7

    • SLC17A7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064705.1  
    ENSEMBL proteins: 
     ENSP00000441767   ENSP00000221485  
    Reactome Protein details: Q9P2U7
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    Uscn Proteins for SLC17A7

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008021synaptic vesicle ----
    GO:0016021integral to membrane IDA10820226
    GO:0019717synaptosome ----
    GO:0030054cell junction IEA--


    SLC17A7 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC17A7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC17A7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9P2U7

    ProtoNet protein and cluster: Q9P2U7

    UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7
    Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily


    Function
    for SLC17A7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7
    Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural
    cells. May also mediate the transport of inorganic phosphate

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    hsa-miR-194* hsa-miR-3164 hsa-miR-142-5p hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-486-3p hsa-miR-488
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    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005313L-glutamate transmembrane transporter activity TAS--
    GO:0005315inorganic phosphate transmembrane transporter activity IEA--
    GO:0015319sodium:inorganic phosphate symporter activity IDA10820226
    GO:0015321sodium-dependent phosphate transmembrane transporter activity IEA--


    SLC17A7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC17A7:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for SLC17A7: Slc17a7tm1Edw Slc17a7tm1Rmnd Slc17a7tm1Lex
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Slc17a7):
     behavior/neurological  growth/size  integument  mortality/aging  nervous system 
     vision/eye 

    SLC17A7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC17A7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    4Neuroscience
    		Neuroscience1.00
    5Organic anion transporters
    		Organic anion transporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SLC17A7
        Neuroscience

    1 BioSystems Pathway for SLC17A7 
        Synaptic Vesicle Pathway

    5/9        Reactome Pathways for SLC17A7 (see all 9)
        Transmission across Chemical Synapses
    Neurotransmitter Release Cycle
    Neuronal System
    Glutamate Neurotransmitter Release Cycle
    Transmembrane transport of small molecules


    1         Kegg Pathway  (Kegg details for SLC17A7):
        Glutamatergic synapse


    SLC17A7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC17A7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for SLC17A7 (Q9P2U73 ENSP000002214854) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL2Q999623, ENSP000003699814I2D: score=2 STRING: ENSP00000369981
    CPLX1ENSP000003056134STRING: ENSP00000305613
    RAB3AENSP000002222564STRING: ENSP00000222256
    RIMS1ENSP000002648394STRING: ENSP00000264839
    SYT1ENSP000002612054STRING: ENSP00000261205
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006817phosphate ion transport TAS8632143
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007616long-term memory IEA--


    SLC17A7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC17A7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC17A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC17A7

    1 HMDB Compound for SLC17A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    5 Novoseek chemical compound relationships for SLC17A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 79.4 129 15961236 (8), 17581970 (5), 11985876 (3), 11698620 (3) (see all 57)
    gaba 48.9 16 11698620 (2), 16546297 (2), 17503488 (1), 17623043 (1) (see all 7)
    methamphetamine 24.8 4 17581970 (3)
    nmda 7.68 3 15384067 (1), 17596438 (1)
    chloride 1.48 2 10938000 (1), 12444014 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC17A7 / VGLU1 

    Transcripts
    for SLC17A7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC17A7 gene: 
    NM_020309.3  

    Unigene Cluster for SLC17A7:

    Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
    Hs.375616  [show with all ESTs]
    Unigene Representative Sequence: NM_020309
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543531(uc002pnq.1) ENST00000221485(uc002pno.3 uc002pnp.3)


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    hsa-miR-194* hsa-miR-3164 hsa-miR-142-5p hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-486-3p hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmid: SLC17A7 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB032436.1 AK091061.1 AK095659.2 AK289622.1 AK294226.1 AK294405.1 BC059379.1 

    8 DOTS entries:

    DT.97785527  DT.92426144  DT.86851874  DT.97785140  DT.97786220  DT.97791534  DT.121419286  DT.91666041 

    24/106 AceView cDNA sequences (see all 106):

    AL157531 AK091061 BE892556 CB153176 BM672805 AX746758 AL119539 BQ636968 
    AB032436 AI198224 BX477970 AW594475 CB117584 R13975 BM708393 BM920768 
    CB117557 BF960075 NM_020309 CB153243 BM544770 CF995727 AA338605 T16374 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A7    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:              -                                                     -     -                                                   
    SP2:                                                                    -                             -                           
    SP3:                                                                                                                              
    SP4:                                                                    -     -                 -                                 
    SP5:        -     -                                                                                                               


    ECgene alternative splicing isoforms for SLC17A7

    Expression
    for SLC17A7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC17A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGGGAATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC17A7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC17A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC17A7

    SOURCE GeneReport for Unigene cluster: Hs.375616

    UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7
    Tissue specificity: Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex,
    hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC17A7: 
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              Terminal Differentiation Markers in human mouse rat
              GABA & Glutamate in human mouse rat

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    In Situ
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    Orthologs
    for SLC17A7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC17A7 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc17a71 , 5 solute carrier family 17 (sodium-dependent inorganic more1, 5 90.24(n)1
    98.57(a)1    		   7 (29.16 cM)5
    729611  NM_182993.21  NP_892038.21 
     451639215 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC17A76
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343355.1(439621-457295)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc17a71 solute carrier family 17 (sodium-dependent inorganic more 73.19(n)
    84.64(a)    		   795293  NM_001098755.1  NP_001092225.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG98873 high affinity inorganic phosphate:sodium
    symporter    		 48(a)
    (best of 20)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea T07A5.33
    eat-41    		 sodium/phosphate transporter protein3
    Protein EAT-41    		 43(a)
    (best of 9)3
    51.38(n)1
    50.1(a)1    		   III(10372084-10374948)3
    1762911  NM_066622.31  NP_499023.31 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ANTR21 putative anion transporter 2 48.7(n)
    39.02(a)    		   827908  NM_116261.4  NP_567175.2 
    rice
    (Oryza sativa)    		 Liliopsida Os09g05704001 hypothetical protein 48.05(n)
    37.8(a)    		   4347913  NM_001070521.1  NP_001063986.1 


    ENSEMBL Gene Tree for SLC17A7 (if available)
    TreeFam Gene Tree for SLC17A7 (if available) 

    Paralogs
    for SLC17A7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC17A7 gene
    SLC17A82  SLC17A32  SLC17A62  SLC17A42  SLC17A12  SLC17A52  SLC17A92  SLC17A22  
    8 SIMAP similar genes for SLC17A7 using alignment to 5 protein entries:     VGLU1_HUMAN (see all proteins):
    SLC17A6    SLC17A8    SLC17A5    SLC17A4    SLC17A1    SLC17A2
    SLC17A3    C20orf59

    SLC17A7 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC17A7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/269 NCBI SNPs in SLC17A7 are shown (see all 269)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs557323301,2
    		C,F,--49932178(+) CTAATA/GTACAG 2 -- ds50016Minor allele frequency- G:0.26WA NA CSA EA 364
    rs1818072511,2
    		--49932199(+) GCTGTA/GATCAG 2 -- ds50010--------
    rs1477916981,2
    		--49932355(+) GAGGAG/TGGGCT 2 -- ds50010--------
    rs104038851,2
    		C,A,--49932393(+) GAGGGA/G/TCGGGG 2 -- ds50014NA CSA EA 125
    rs790991991,2
    		C--49932538(+) GAGGGG/TCTGGG 2 -- ds50010--------
    rs1848164251,2
    		--49932608(+) GAGGAC/TGGGGC 1 -- ds50010--------
    rs1901960221,2
    		--49932611(+) GACGGA/GGCTGG 1 -- ds50010--------
    rs1114744391,2
    		C--49932657(+) AACTGT/AGCCTA 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs789361891,2
    		--49932723(+) AGAGAC/TACAAA 1 -- ut310--------
    rs10435581,2
    		C,F,A,H,--49932762(-) AGGAGA/CCAGGG 1 -- ut3125Minor allele frequency- C:0.27MN NS EA NA WA CSA 2537

    HapMap Linkage Disequilibrium report for SLC17A7 (49932655 - 49945617 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SLC17A7
         3 CNVs: 89278 5110 32261

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    Disorders / Diseases
    for SLC17A7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC17A7 for disorders           About GeneDecksing

    OMIM gene information: 605208    OMIM disorders: --

    13 diseases for SLC17A7:    About MalaCards
    major depressive disorder    febrile seizures    neuronitis    bipolar disorder
    seizures    parkinson's disease    cholera    alzheimer's disease
    schizophrenia    cerebritis    cervicitis    retinitis
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for SLC17A7:
    Schizophrenia     Cholera

    2 Novoseek disease relationships for SLC17A7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 28.4 14 19720501 (3), 15653259 (2), 11588596 (2), 17371293 (1) (see all 6)
    epilepsy 3.35 2 15961236 (1), 16083865 (1), 17711980 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC17A7 (3 documents)

    Export disorders for SLC17A7 gene to outside databases

    Publications
    for SLC17A7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC17A7 gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with SLC17A7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 10820226)1, 2, 3, 9 Aihara Y....Takeda J. (2000)
    2. Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 8632143)1, 3 Ni B....Paul S.M. (1996)
    3. Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex. (PubMed id 15961236)1, 9 Alonso-Nanclares L. and De Felipe J. (2005)
    4. Resequencing and association study of vesicular gluta mate transporter 1 gene (VGLUT1) with schizophrenia. (PubMed id 19720501)1, 9 Shen Y.C....Chen C.H. (2009)
    5. Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. (PubMed id 17531353)1, 9 Kashani A....El Mestikawy S. (2008)
    6. Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. (PubMed id 15653259)1, 9 Eastwood S.L. and Harrison P.J. (2005)
    7. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. (PubMed id 11001057)1, 9 Takamori S....Jahn R. (2000)
    8. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. (PubMed id 10938000)1, 9 Bellocchio E.E....Edwards R.H. (2000)
    9. Glutamatergic and GABAergic innervation of human gonad otropin-releasing hormone-I neurons. (PubMed id 22510271)1 Hrabovszky E....Liposits Z. (2012)
    10. Expression of VGluT1 and VGAT mRNAs in human dorsolat eral prefrontal cortex during development and in schizophrenia. (PubMed id 21396926)1 Fung S.J....Weicker C.S. (2011)

    External Searches for SLC17A7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC17A7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57030 HGNC: 16704 AceView: SLC17A7 Ensembl:ENSG00000104888 euGenes: HUgn57030
    ECgene: SLC17A7 Kegg: 57030 H-InvDB: SLC17A7

    Other Databases showing SLC17A7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC17A7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC17A7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC17A7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC17A7 gene:
    Search GeneIP for patents involving SLC17A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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