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Aliases for SLC17A7 Gene

Aliases for SLC17A7 Gene

  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 2 3
  • VGLUT1 3 4 6
  • BNPI 3 4 6
  • Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7 2 3
  • Brain-Specific Na(+)-Dependent Inorganic Phosphate Cotransporter 3 4
  • Vesicular Glutamate Transporter 1 2 3
  • Solute Carrier Family 17 Member 7 3 4
  • Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter 3

External Ids for SLC17A7 Gene

Previous GeneCards Identifiers for SLC17A7 Gene

  • GC19M050591
  • GC19M050301
  • GC19M054608
  • GC19M054624
  • GC19M049933
  • GC19M046309
  • GC19M049934

Summaries for SLC17A7 Gene

Entrez Gene Summary for SLC17A7 Gene

  • The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC17A7 Gene

SLC17A7 (Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7) is a Protein Coding gene. Diseases associated with SLC17A7 include schizophrenia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include L-glutamate transmembrane transporter activity and inorganic phosphate transmembrane transporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A7 Gene

  • Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Wiki entry for SLC17A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A7 Gene

Genomics for SLC17A7 Gene

Regulatory Elements for SLC17A7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC17A7 Gene

Start:
49,429,398 bp from pter
End:
49,442,360 bp from pter
Size:
12,963 bases
Orientation:
Minus strand

Genomic View for SLC17A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC17A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A7 Gene

Proteins for SLC17A7 Gene

  • Protein details for SLC17A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2U7-VGLU1_HUMAN
    Recommended name:
    Vesicular glutamate transporter 1
    Protein Accession:
    Q9P2U7
    Secondary Accessions:
    • B4DFR9
    • B4DG46
    • Q6PCD0

    Protein attributes for SLC17A7 Gene

    Size:
    560 amino acids
    Molecular mass:
    61613 Da
    Quaternary structure:
    • Interacts with SHANK3.

    Alternative splice isoforms for SLC17A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A7 Gene

Proteomics data for SLC17A7 Gene at MOPED

Post-translational modifications for SLC17A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC17A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC17A7 (SLC17A7)

No data available for DME Specific Peptides for SLC17A7 Gene

Domains for SLC17A7 Gene

Gene Families for SLC17A7 Gene

Protein Domains for SLC17A7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P2U7

UniProtKB/Swiss-Prot:

VGLU1_HUMAN :
  • Q9P2U7
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
genes like me logo Genes that share domains with SLC17A7: view

Function for SLC17A7 Gene

Molecular function for SLC17A7 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Ontology (GO) - Molecular Function for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS --
GO:0005315 inorganic phosphate transmembrane transporter activity IEA --
GO:0015319 sodium:inorganic phosphate symporter activity IDA 10820226
GO:0015321 sodium-dependent phosphate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC17A7: view
genes like me logo Genes that share phenotypes with SLC17A7: view

Animal Models for SLC17A7 Gene

MGI Knock Outs for SLC17A7:

Animal Model Products

CRISPR Products

miRNA for SLC17A7 Gene

miRTarBase miRNAs that target SLC17A7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC17A7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC17A7 Gene

Localization for SLC17A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A7 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A7 Gene COMPARTMENTS Subcellular localization image for SLC17A7 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane IDA 10820226
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane TAS --
genes like me logo Genes that share ontologies with SLC17A7: view

Pathways for SLC17A7 Gene

genes like me logo Genes that share pathways with SLC17A7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Terminal Differentiation Markers in human,mouse,rat
    • GABA & Glutamate in human,mouse,rat

Gene Ontology (GO) - Biological Process for SLC17A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006817 phosphate ion transport TAS 8632143
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0007616 long-term memory IEA --
genes like me logo Genes that share ontologies with SLC17A7: view

Compounds for SLC17A7 Gene

(1) HMDB Compounds for SLC17A7 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(5) Novoseek inferred chemical compound relationships for SLC17A7 Gene

Compound -log(P) Hits PubMed IDs
glutamate 79.4 85
gaba 48.9 9
methamphetamine 24.8 3
nmda 7.68 2
chloride 1.48 2
genes like me logo Genes that share compounds with SLC17A7: view

Transcripts for SLC17A7 Gene

Unigene Clusters for SLC17A7 Gene

Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC17A7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - -
SP3:
SP4: - - -
SP5: - -

Relevant External Links for SLC17A7 Gene

GeneLoc Exon Structure for
SLC17A7
ECgene alternative splicing isoforms for
SLC17A7

Expression for SLC17A7 Gene

mRNA expression in normal human tissues for SLC17A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A7 Gene

This gene is overexpressed in Brain - Cortex (9.5), Brain - Anterior cingulate cortex (BA24) (8.9), Brain - Frontal Cortex (BA9) (8.4), Brain - Hippocampus (7.9), Brain - Amygdala (6.5), Brain - Cerebellum (4.5), and Brain - Cerebellar Hemisphere (4.5).

Protein differential expression in normal tissues for SLC17A7 Gene

This gene is overexpressed in Frontal cortex (43.4), Brain (16.2), and Retina (6.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC17A7 Gene

SOURCE GeneReport for Unigene cluster for SLC17A7 Gene Hs.375616

mRNA Expression by UniProt/SwissProt for SLC17A7 Gene

Q9P2U7-VGLU1_HUMAN
Tissue specificity: Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.
genes like me logo Genes that share expressions with SLC17A7: view

Expression partners for SLC17A7 Gene

In Situ Assay Products

Orthologs for SLC17A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC17A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC17A7 35
  • 93.33 (n)
  • 98.93 (a)
SLC17A7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC17A7 35
  • 93.69 (n)
  • 98.75 (a)
SLC17A7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a7 35
  • 90.24 (n)
  • 98.57 (a)
Slc17a7 16
Slc17a7 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC17A7 35
  • 98.44 (n)
  • 97.74 (a)
SLC17A7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc17a7 35
  • 89.82 (n)
  • 98.39 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC17A7 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC17A7 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc17a7 35
  • 73.26 (n)
  • 85.21 (a)
zebrafish
(Danio rerio)
Actinopterygii slc17a7 35
  • 73.05 (n)
  • 84.48 (a)
slc17a6b 36
  • 75 (a)
OneToMany
slc17a7 36
  • 77 (a)
OneToMany
SLC17A7 (3 of 3) 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK02623 37
  • 28 (a)
CG15094 37
  • 32 (a)
CG15096 37
  • 34 (a)
CG2003 37
  • 28 (a)
CG30265 37
  • 30 (a)
CG30272 37
  • 30 (a)
CG3036 37
  • 33 (a)
CG3649 37
  • 29 (a)
CG4288 37
  • 41 (a)
CG4726 37
  • 30 (a)
CG6978 37
  • 35 (a)
CG7881 37
  • 29 (a)
CG8791 37
  • 29 (a)
CG9825 37
  • 31 (a)
CG9826 37
  • 31 (a)
CG9864 37
  • 31 (a)
CG9887 37
  • 48 (a)
l(2)08717 37
  • 31 (a)
NaPi-T 37
  • 30 (a)
Picot 37
  • 34 (a)
VGlut 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C02C2.4 37
  • 26 (a)
F12B6.2a 37
  • 25 (a)
F12B6.2b 37
  • 25 (a)
F21F8.11 37
  • 26 (a)
K10H10.1 37
  • 24 (a)
R10D12.1 37
  • 25 (a)
T07A5.3 37
  • 43 (a)
T09B9.2 37
  • 25 (a)
ZK54.1 37
  • 35 (a)
eat-4 35
  • 51.8 (n)
  • 50.92 (a)
eat-4 36
  • 44 (a)
ManyToMany
vglu-2 36
  • 35 (a)
ManyToMany
vglu-3 36
  • 37 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PHT4;1 35
  • 45.85 (n)
  • 37.56 (a)
rice
(Oryza sativa)
Liliopsida Os01g0279700 35
  • 46.49 (n)
  • 37.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for SLC17A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC17A7 Gene

ENSEMBL:
Gene Tree for SLC17A7 (if available)
TreeFam:
Gene Tree for SLC17A7 (if available)

Paralogs for SLC17A7 Gene

Paralogs for SLC17A7 Gene

Selected SIMAP similar genes for SLC17A7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC17A7: view

Variants for SLC17A7 Gene

Sequence variations from dbSNP and Humsavar for SLC17A7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1043534 -- 49,430,242(-) CAGGG(C/T)TTTAT utr-variant-3-prime
rs1043558 -- 49,429,505(-) AGGAG(A/C)CAGGG utr-variant-3-prime
rs1320301 -- 49,439,175(-) AGAGG(A/G)AGAGA intron-variant
rs1578944 -- 49,442,593(+) TGTTC(C/T)CGCCC upstream-variant-2KB
rs1801648 -- 49,429,695(-) CCCAA(A/T)TCCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC17A7 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv912263 CNV Loss 21882294
nsv912264 CNV Loss 21882294

Relevant External Links for SLC17A7 Gene

HapMap Linkage Disequilibrium report
SLC17A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A7 Gene

Disorders for SLC17A7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC17A7 Gene in MalaCards »

(1) Diseases for SLC17A7 Gene including...

(2) University of Copenhagen DISEASES for SLC17A7 Gene

(2) Novoseek inferred disease relationships for SLC17A7 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 28.4 10
epilepsy 3.35 3

Relevant External Links for SLC17A7

Genetic Association Database (GAD)
SLC17A7
Human Genome Epidemiology (HuGE) Navigator
SLC17A7
genes like me logo Genes that share disorders with SLC17A7: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SLC17A7 Gene

Publications for SLC17A7 Gene

  1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PMID: 10820226) Aihara Y. … Takeda J. (J. Neurochem. 2000) 2 3 4 23
  2. Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia. (PMID: 19720501) Shen Y.C. … Chen C.H. (Schizophr. Res. 2009) 3 23 48
  3. Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter. (PMID: 8632143) Ni B. … Paul S.M. (J. Neurochem. 1996) 2 3
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 48

Products for SLC17A7 Gene

Sources for SLC17A7 Gene

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