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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC17A7 Gene

protein-coding GIFtS: 60
GCID: GC19M049933

solute carrier family 17 (sodium-dependent inorganic phosphate...

Explore 13 diseases affiliated with
SLC17A7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7¹ ²		Solute Carrier Family 17 Member 7² ³
BNPI¹ ² ³ ⁵		Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter²
VGLUT1¹ ² ³ ⁵		Vesicular Glutamate Transporter 1²
Brain-Specific Na(+)-Dependent Inorganic Phosphate Cotransporter² ³		VGluT1³

External Ids:	HGNC: 16704¹	Entrez Gene: 57030²	Ensembl: ENSG00000104888⁷	OMIM: 605208⁵	UniProtKB: Q9P2U7³

Export aliases for SLC17A7 gene to outside databases

Previous GC identifers: GC19M050591 GC19M050301 GC19M054608 GC19M054624 GC19M046309

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC17A7:

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically

expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic

vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated

Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi

cotransporter family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7

Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural

cells. May also mediate the transport of inorganic phosphate

Gene Wiki entry for SLC17A7 (Vesicular glutamate transporter 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC17A7 gene promoter:
C/EBPbeta Pax-5 Pax-2 Tal-1beta E47 MZF-1 Pax-2b HOXA5 ITF-2 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC17A7 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC17A7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33

SLC17A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A7 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M049933: view genomic region (about GC identifiers)

Start:	49,932,655 bp from pter	End:	49,945,617 bp from pter
Size:	12,963 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7 (See protein sequence)

Recommended Name: Vesicular glutamate transporter 1

Size: 560 amino acids; 61613 Da

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane;

Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity)

Secondary accessions: Q6PCD0

Explore the universe of human proteins at neXtProt for SLC17A7: NX_Q9P2U7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P2U7

SLC17A7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_064705.1

ENSEMBL proteins:

ENSP00000441767 ENSP00000221485

Reactome Protein details: Q9P2U7
Human Recombinant Protein Products for SLC17A7:

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	Uscn Proteins for SLC17A7

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008021	synaptic vesicle	--	--
GO:0016021	integral to membrane	IDA	10820226
GO:0019717	synaptosome	--	--
GO:0030054	cell junction	IEA	--

SLC17A7 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC17A7 for domains About GeneDecksing

3 InterPro domains/families:

IPR020846 MFS_dom

IPR011701 MFS

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q9P2U7

ProtoNet protein and cluster: Q9P2U7

UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7

Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: VGLU1_HUMAN, Q9P2U7

Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural

cells. May also mediate the transport of inorganic phosphate

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005313	L-glutamate transmembrane transporter activity	TAS	--
GO:0005315	inorganic phosphate transmembrane transporter activity	IEA	--
GO:0015319	sodium:inorganic phosphate symporter activity	IDA	10820226
GO:0015321	sodium-dependent phosphate transmembrane transporter activity	IEA	--

SLC17A7 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SLC17A7:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Slc17a7):

behavior/neurological	growth/size	integument	mortality/aging	nervous system
vision/eye

SLC17A7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SLC17A7: Slc17a7^tm1Edw Slc17a7^tm1Rmnd Slc17a7^tm1Lex

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC17A7

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		hsa-miR-194* hsa-miR-3164 hsa-miR-142-5p hsa-miR-520f hsa-miR-4254 hsa-miR-106a hsa-miR-486-3p hsa-miR-488

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amino acid and oligopeptide SLC transporters

Amino acid and oligopeptide SLC transporters

1.00

Transport of inorganic cations/anions and amino acids/oligopeptides

0.52

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Transmission across Chemical Synapses

Transmission across Chemical Synapses

1.00

Neuronal System

0.67

Neuroscience

Neuroscience

1.00

Organic anion transporters

Organic anion transporters

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for SLC17A7

Neuroscience

1 BioSystems Pathway for SLC17A7

Synaptic Vesicle Pathway

5/9 Reactome Pathways for SLC17A7 (see all 9)

	Transmission across Chemical Synapses
	Neurotransmitter Release Cycle
	Neuronal System
	Glutamate Neurotransmitter Release Cycle
	Transmembrane transport of small molecules

1 Kegg Pathway (Kegg details for SLC17A7):

Glutamatergic synapse

SLC17A7 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC17A7

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for SLC17A7 (Q9P2U7³ ENSP00000221485⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3GL2	Q99962³, ENSP00000369981⁴	I2D: score=2 STRING: ENSP00000369981
CPLX1	ENSP00000305613⁴	STRING: ENSP00000305613
RAB3A	ENSP00000222256⁴	STRING: ENSP00000222256
RIMS1	ENSP00000264839⁴	STRING: ENSP00000264839
SYT1	ENSP00000261205⁴	STRING: ENSP00000261205

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	TAS	--
GO:0006817	phosphate ion transport	TAS	8632143
GO:0007268	synaptic transmission	TAS	--
GO:0007269	neurotransmitter secretion	TAS	--
GO:0007616	long-term memory	IEA	--

SLC17A7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC17A7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC17A7

1 HMDB Compound for SLC17A7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

5 Novoseek chemical compound relationships for SLC17A7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glutamate	79.4	129	15961236 (8), 17581970 (5), 11985876 (3), 11698620 (3) (see all 57)
gaba	48.9	16	11698620 (2), 16546297 (2), 17503488 (1), 17623043 (1) (see all 7)
methamphetamine	24.8	4	17581970 (3)
nmda	7.68	3	15384067 (1), 17596438 (1)
chloride	1.48	2	10938000 (1), 12444014 (1)

Search CenterWatch for drugs/clinical trials and news about SLC17A7 / VGLU1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC17A7 gene:

NM_020309.3

Unigene Cluster for SLC17A7:

Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

Hs.375616 [show with all ESTs]

Unigene Representative Sequence: NM_020309

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000543531(uc002pnq.1) ENST00000221485(uc002pno.3 uc002pnp.3)

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Additional cDNA sequence:

AB032436.1 AK091061.1 AK095659.2 AK289622.1 AK294226.1 AK294405.1 BC059379.1

8 DOTS entries:

DT.97785527 DT.92426144 DT.86851874 DT.97785140 DT.97786220 DT.97791534 DT.121419286 DT.91666041

24/106 AceView cDNA sequences (see all 106):

AL157531 AK091061 BE892556 CB153176 BM672805 AX746758 AL119539 BQ636968

AB032436 AI198224 BX477970 AW594475 CB117584 R13975 BM708393 BM920768

CB117557 BF960075 NM_020309 CB153243 BM544770 CF995727 AA338605 T16374

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A7 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b
SP1:					-																		-		-
SP2:																							-										-
SP3:
SP4:																							-		-						-
SP5:			-		-

ECgene alternative splicing isoforms for SLC17A7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC17A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGGGAATG

About this image

SLC17A7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC17A7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC17A7

SOURCE GeneReport for Unigene cluster: Hs.375616

UniProtKB/Swiss-Prot: VGLU1_HUMAN, Q9P2U7

Tissue specificity: Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex,

hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe

SABiosciences Expression via Pathway-Focused PCR Arrays including SLC17A7:

Cell Lineage Identification in human mouse rat

Terminal Differentiation Markers in human mouse rat

GABA & Glutamate in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC17A7 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slc17a7^{1 , 5}	solute carrier family 17 (sodium-dependent inorganic more^{1, 5}	90.24(n)¹ 98.57(a)¹		7 (29.16 cM)⁵ 72961¹ NM_182993.2¹ NP_892038.2¹ 45163921⁵
lizard (Anolis carolinensis)	Reptilia	SLC17A7⁶	--	81(a)	1 ↔ 1	GL343355.1(439621-457295)
zebrafish (Danio rerio)	Actinopterygii	slc17a7¹	solute carrier family 17 (sodium-dependent inorganic more	73.19(n) 84.64(a)		795293 NM_001098755.1 NP_001092225.1
fruit fly (Drosophila melanogaster)	Insecta	CG9887³	high affinity inorganic phosphate:sodium symporter	48(a) (best of 20)		--
worm (Caenorhabditis elegans)	Secernentea	T07A5.3³ eat-4¹	sodium/phosphate transporter protein³ Protein EAT-4¹	43(a) (best of 9)³ 51.38(n)¹ 50.1(a)¹		III(10372084-10374948)³ 176291¹ NM_066622.3¹ NP_499023.3¹
thale cress (Arabidopsis thaliana)	eudicotyledons	ANTR2¹	putative anion transporter 2	48.7(n) 39.02(a)		827908 NM_116261.4 NP_567175.2
rice (Oryza sativa)	Liliopsida	Os09g0570400¹	hypothetical protein	48.05(n) 37.8(a)		4347913 NM_001070521.1 NP_001063986.1

ENSEMBL Gene Tree for SLC17A7 (if available)
TreeFam Gene Tree for SLC17A7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC17A7 gene

SLC17A8² SLC17A3² SLC17A6² SLC17A4² SLC17A1² SLC17A5² SLC17A9² SLC17A2²

8 SIMAP similar genes for SLC17A7 using alignment to 5 protein entries: VGLU1_HUMAN (see all proteins):

SLC17A6 SLC17A8 SLC17A5 SLC17A4 SLC17A1 SLC17A2

SLC17A3 C20orf59

SLC17A7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55732330^1,2	C,F	--	49932178(+)	`CTAATA/GTACAG`	2	--	ds500¹		6		WA NA CSA EA	364
rs181807251^1,2		--	49932199(+)	`GCTGTA/GATCAG`	2	--	ds500¹		0	--	--	--	--
rs147791698^1,2		--	49932355(+)	`GAGGAG/TGGGCT`	2	--	ds500¹		0	--	--	--	--
rs10403885^1,2	C,A	--	49932393(+)	`GAGGGA/G/TCGGGG`	2	--	ds500¹		4		NA CSA EA	125
rs79099199^1,2	C	--	49932538(+)	`GAGGGG/TCTGGG`	2	--	ds500¹		0	--	--	--	--
rs184816425^1,2		--	49932608(+)	`GAGGAC/TGGGGC`	1	--	ds500¹		0	--	--	--	--
rs190196022^1,2		--	49932611(+)	`GACGGA/GGCTGG`	1	--	ds500¹		0	--	--	--	--
rs111474439^1,2	C	--	49932657(+)	`AACTGT/AGCCTA`	1	--	ut3¹		1		CSA	1
rs78936189^1,2		--	49932723(+)	`AGAGAC/TACAAA`	1	--	ut3¹		0	--	--	--	--
rs1043558^1,2	C,F,A,H	--	49932762(-)	`AGGAGA/CCAGGG`	1	--	ut3¹		25		MN NS EA NA WA CSA	2537

HapMap Linkage Disequilibrium report for SLC17A7 (49932655 - 49945617 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SLC17A7
3 CNVs: 89278 5110 32261

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC17A7 for disorders           About GeneDecksing

OMIM gene information: 605208    OMIM disorders: --

13 diseases for SLC17A7:    About MalaCards

major depressive disorder febrile seizures neuronitis bipolar disorder

seizures parkinson's disease cholera alzheimer's disease

schizophrenia cerebritis cervicitis retinitis

pancreatitis

2 diseases from the University of Copenhagen DISEASES database for SLC17A7:

Schizophrenia Cholera

2 Novoseek disease relationships for SLC17A7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	28.4	14	19720501 (3), 15653259 (2), 11588596 (2), 17371293 (1) (see all 6)
epilepsy	3.35	2	15961236 (1), 16083865 (1), 17711980 (1)

Human Genome Epidemiology (HuGE) Navigator: SLC17A7 (3 documents)

Export disorders for SLC17A7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC17A7 gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with SLC17A7)

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Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 10820226)^{1, 2, 3, 9} Aihara Y....Takeda J. (2000)
Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 8632143)^{1, 3} Ni B....Paul S.M. (1996)
Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex. (PubMed id 15961236)^{1, 9} Alonso-Nanclares L. and De Felipe J. (2005)
Resequencing and association study of vesicular gluta mate transporter 1 gene (VGLUT1) with schizophrenia. (PubMed id 19720501)^{1, 9} Shen Y.C....Chen C.H. (2009)
Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. (PubMed id 17531353)^{1, 9} Kashani A....El Mestikawy S. (2008)
Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. (PubMed id 15653259)^{1, 9} Eastwood S.L. and Harrison P.J. (2005)
Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. (PubMed id 11001057)^{1, 9} Takamori S....Jahn R. (2000)
Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. (PubMed id 10938000)^{1, 9} Bellocchio E.E....Edwards R.H. (2000)
Glutamatergic and GABAergic innervation of human gonad otropin-releasing hormone-I neurons. (PubMed id 22510271)¹ Hrabovszky E....Liposits Z. (2012)
Expression of VGluT1 and VGAT mRNAs in human dorsolat eral prefrontal cortex during development and in schizophrenia. (PubMed id 21396926)¹ Fung S.J....Weicker C.S. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57030	HGNC: 16704	AceView: SLC17A7	Ensembl:ENSG00000104888	euGenes: HUgn57030
ECgene: SLC17A7	Kegg: 57030	H-InvDB: SLC17A7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC17A7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC17A7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC17A7 gene:
Search GeneIP for patents involving SLC17A7

GeneCards and IP:
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