Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC17A6 Gene

protein-coding   GIFtS: 59
GCID: GC11P022316

Solute Carrier Family 17 (Vesicular Glutamate Transporter),...

(Previous names: solute carrier family 17 (sodium-dependent inorganic phosphate...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member
61 2
     Vesicular Glutamate Transporter 21 2
DNPI2 3 5     Differentiation-Associated BNPI2 3
VGLUT22 3 5     Differentiation-Associated Na(+)-Dependent Inorganic Phosphate
Cotransporter2 3
Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate
Cotransporter), Member 61 2
     Solute Carrier Family 17 Member 62 3
Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter1 2     VGluT23

External Ids:    HGNC: 167031   Entrez Gene: 570842   Ensembl: ENSG000000916647   OMIM: 6075635   UniProtKB: Q9P2U83   

Export aliases for SLC17A6 gene to outside databases

Previous GC identifers: GC11P023776 GC11P023161 GC11P022398 GC11P022323 GC11P022042


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC17A6 Gene: 
SLC17A6 (solute carrier family 17 (vesicular glutamate transporter), member 6) is a protein-coding gene. Diseases associated with SLC17A6 include gnathodiaphyseal dysplasia, and major depressive disorder, and among its related super-pathways are Synaptic Vesicle Pathway and Amino acid transport across the plasma membrane. GO annotations related to this gene include L-glutamate transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC17A7.

UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8
Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory
neural cells. May also mediate the transport of inorganic phosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC17A6 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-2   Pax-2a   E2F-2   E2F   E2F-1   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC17A6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC17A6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3   Ensembl cytogenetic band:  11p14.3   HGNC cytogenetic band: 11p14.3

SLC17A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P022316:  view genomic region     (about GC identifiers)

Start:
22,359,643 bp from pter      End:
22,401,049 bp from pter
Size:
41,407 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8 (See protein sequence)
Recommended Name: Vesicular glutamate transporter 2  
Size: 582 amino acids; 64392 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane;
Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity)
Developmental stage: Expressed in fetal brain
Secondary accessions: A6NKS2

Explore the universe of human proteins at neXtProt for SLC17A6: NX_Q9P2U8

Explore proteomics data for SLC17A6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2U8

  • SLC17A6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC17A6 Protein Expression
    REFSEQ proteins: NP_065079.1  
    ENSEMBL proteins: 
     ENSP00000263160  
    Reactome Protein details: Q9P2U8
    Human Recombinant Protein Products for SLC17A6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC17A6
    GenScript Custom Purified and Recombinant Proteins Services for SLC17A6
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC17A6 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle ----
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane TAS--
    GO:0043005neuron projection IEA--

    SLC17A6 for ontologies           About GeneDecksing



    SLC17A6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SLC17A6 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC17A6
    GenScript Custom Superior Antibodies Services for SLC17A6
    Novus Biologicals SLC17A6 Antibodies
    Abcam antibodies for SLC17A6
    Cloud-Clone Corp. Antibodies for SLC17A6 
    ThermoFisher Antibodies for SLC17A6
    LSBio Antibodies in human, mouse, rat for SLC17A6 

    Assay Products for SLC17A6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC17A6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC17A6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC17A6 
    Cloud-Clone Corp. CLIAs for SLC17A6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Vesicular glutamate transporter 2 
    Vesicular glutamate transporters (VGLUTs)

    3 InterPro protein domains:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9P2U8

    ProtoNet protein and cluster: Q9P2U8

    UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8
    Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily


    SLC17A6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VGLU2_HUMAN, Q9P2U8
    Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory
    neural cells. May also mediate the transport of inorganic phosphate

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005313L-glutamate transmembrane transporter activity IEA--
    GO:0015293symporter activity IEA--
         
    SLC17A6 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Slc17a6):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  integument 
     mortality/aging  nervous system  no phenotypic analysis  normal  respiratory system 

    SLC17A6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC17A6: Slc17a6tm1.1Lowl Slc17a6tm1.2Edw Slc17a6tm1.2Jder Slc17a6tm1Lex Slc17a6tm1.1Kldr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC17A6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC17A6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC17A6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC17A6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC17A6
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC17A6 (see all 23):
    hsa-miR-137 hsa-miR-200a hsa-miR-25 hsa-miR-519a hsa-miR-218 hsa-miR-141 hsa-miR-4325 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC17A6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC17A6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC17A6
    Sirion Biotech Customized adenovirus for overexpression of SLC17A6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC17A6 (see all 5)
    OriGene ORF clones in mouse, rat for SLC17A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC17A6 (NM_020346)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC17A6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC17A6
    Sirion Biotech Customized lentivirus for stable overexpression of SLC17A6 
                         Customized lentivirus expression plasmids for stable overexpression of SLC17A6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC17A6
    Search LifeMap BioReagents cell lines for SLC17A6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC17A6 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic vesicle cycle0.50
    Synaptic Vesicle Pathway0.50
    2Amino acid and oligopeptide SLC transporters
    Amino acid and oligopeptide SLC transporters0.63
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    3Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    Glutamatergic synapse0.39
    4SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    5Organic anion transporters
    Organic anion transporters

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SLC17A6
        Glutamic acid signaling


    1 Cell Signaling Technology (CST) Pathway for SLC17A6
        Neuroscience

    1 BioSystems Pathway for SLC17A6
        Synaptic Vesicle Pathway

    5        Reactome Pathways for SLC17A6
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides
    Organic anion transporters


    4         Kegg Pathways  (Kegg details for SLC17A6):
        Synaptic vesicle cycle
    Retrograde endocannabinoid signaling
    Glutamatergic synapse
    Nicotine addiction


    SLC17A6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC17A6

    2 Interacting proteins for SLC17A6 (Q9P2U83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSKP432353I2D: score=1 
    TUBA1AQ71U363I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001504neurotransmitter uptake IEA--
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0015813L-glutamate transport ----
    GO:0055085transmembrane transport TAS--

    SLC17A6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC17A6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC17A6 (VGLU2)

    1 HMDB Compound for SLC17A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    6 Novoseek inferred chemical compound relationships for SLC17A6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 77 73 11985876 (3), 11432869 (3), 11551935 (3), 11698620 (3) (see all 38)
    gaba 49.4 8 11698620 (3), 16516863 (1), 16546297 (1), 18611437 (1) (see all 5)
    chloride 5.76 1 11432869 (1)
    atp 0 1 11432869 (1)
    glucose 0 1 12444014 (1)
    hydrogen 0 1 11432869 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC17A6 / VGLU2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC17A6 gene: 
    NM_020346.2  

    Unigene Cluster for SLC17A6:

    Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
    Hs.242821  [show with all ESTs]
    Unigene Representative Sequence: AB032435
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263160(uc001mqk.3) ENST00000534115

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC17A6
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC17A6 (see all 23):
    hsa-miR-137 hsa-miR-200a hsa-miR-25 hsa-miR-519a hsa-miR-218 hsa-miR-141 hsa-miR-4325 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC17A6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC17A6
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC17A6 (see all 5)
    OriGene ORF clones in mouse, rat for SLC17A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC17A6 (NM_020346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC17A6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC17A6
    Sirion Biotech Customized lentivirus for stable overexpression of SLC17A6 
                         Customized lentivirus expression plasmids for stable overexpression of SLC17A6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC17A6
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC17A6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC17A6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC17A6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC17A6

    Additional mRNA sequence: 

    AB032435.1 AK294502.1 AK309131.1 BC069629.1 BC069640.1 BC069646.1 

    2 DOTS entries:

    DT.75113177  DT.120747006 

    24/25 AceView cDNA sequences (see all 25):

    BP361419 BQ188116 BM966897 BQ185289 BC069629 BC069646 CK823303 BC069640 
    BP361895 AL119976 AB032435 BP359897 BP361657 NM_020346 BM893652 BP362340 
    BM273076 BP361810 BP362646 CK823302 BP361755 BP361488 AW128878 BF369840 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC17A6 expression in normal human tissues (normalized intensities)      SLC17A6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCATACACA
    SLC17A6 Expression
    About this image


    SLC17A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 34 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Septum   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon

    See SLC17A6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC17A6

    SOURCE GeneReport for Unigene cluster: Hs.242821

    UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8
    Tissue specificity: Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral
    cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic
    nucleus, temporal lobe and thalamus

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC17A6: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC17A6
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC17A6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC17A6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC17A6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC17A6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC17A6 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc17a61 , 5 solute carrier family 17 (sodium-dependent inorganic more1, 5 88.77(n)1
    97.42(a)1
      7 (32.78 cM)5
    1409191  NM_080853.31  NP_543129.31 
     516218305 
    chicken
    (Gallus gallus)
    Aves SLC17A61 solute carrier family 17 (sodium-dependent inorganic more 84.28(n)
    94.66(a)
      422971  NM_001168383.1  NP_001161855.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC17A66
    Uncharacterized protein
    95(a)
    1 ↔ 1
    1(58641497-58701153)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3987482 glutamate transporter 76.58(n)    AF548627.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc17a6a1 solute carrier family 17 (sodium-dependent inorganic more 74.39(n)
    86.41(a)
      494492  NM_001009982.1  NP_001009982.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98873
    VGlut1
    high affinity inorganic
    phosphate:sodium symporter3
    Vesicular glutamate transporter1
    51(a)
    (best of 19)3
    57.65(n)1
    54.36(a)1
      334271  NM_134837.31  NP_608681.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T07A5.33 sodium/phosphate transporter protein 41(a)
    (best of 9)
      III(10372084-10374948)   --


    ENSEMBL Gene Tree for SLC17A6 (if available)
    TreeFam Gene Tree for SLC17A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC17A6 gene
    SLC17A72  SLC17A82  SLC17A32  SLC17A42  SLC17A12  SLC17A52  SLC17A92  SLC17A22  
    6 SIMAP similar genes for SLC17A6 using alignment to 3 protein entries:     VGLU2_HUMAN (see all proteins):
    SLC17A7    SLC17A8    SLC17A5    SLC17A4    SLC17A2    SLC17A1

    SLC17A6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1068 SNPs in SLC17A6 are shown (see all 1068)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0387104
    A breast cancer sample4--see VAR_0387102 T S mis40--------
    rs1922298861,2
    --22357693(+) AATCAC/TTTACA 1 -- us2k10--------
    rs800399341,2
    F--22357739(+) ATTCTA/GTTTTT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1843321951,2
    --22357756(+) AACTTC/TCCAGA 1 -- us2k10--------
    rs669448371,2
    C,F--22357801(+) ATTTAT/ATGAAC 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs1460201971,2
    --22357826(+) TTTGAA/GAAATA 1 -- us2k10--------
    rs14475151,2
    C,F,A,H--22357886(-) AAGATT/GAAAAG 1 -- us2k1 tfbs38Minor allele frequency- G:0.21MN EA NS WA CSA NA 593
    rs1486934411,2
    --22357944(+) TTTTTG/TGTCTC 1 -- us2k10--------
    rs747486781,2
    C,F--22357959(+) TACTTG/CATCTT 1 -- us2k11Minor allele frequency- C:0.25EA 120
    rs1811141271,2
    C--22357961(+) CTTGAC/TCTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC17A6 (22359643 - 22401049 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC17A6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv38773CNV Loss16902084
    nsv897052CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC17A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC17A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607563    OMIM disorders: --

    12 diseases for SLC17A6:    About MalaCards
    gnathodiaphyseal dysplasia    major depressive disorder    schizophrenia    cholera
    bipolar disorder    parkinson's disease    cerebritis    alzheimer's disease
    neuronitis    prostate cancer    prostatitis    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for SLC17A6:
    Cholera

    SLC17A6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SLC17A6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 0 1 15653259 (1)

    Genetic Association Database (GAD): SLC17A6
    Human Genome Epidemiology (HuGE) Navigator: SLC17A6 (4 documents)

    Export disorders for SLC17A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC17A6 gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with SLC17A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 10820226)1, 2, 9 Aihara Y....Takeda J. (2000)
    2. Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia. (PubMed id 20541370)1, 4 Shen Y.C....Chen C.H. (2010)
    3. [A study of the single nucleotide polymorphism in sev en genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer] (PubMed id 20540360)1, 4 Lisitskaia K.V....Shishkin S.S. (2010)
    4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    6. Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3. (PubMed id 11306821)1, 3 Aihara Y....Takeda J. (2001)
    7. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). (PubMed id 11698620)2, 9 Takamori S....Jahn R. (2001)
    8. Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. (PubMed id 17531353)1, 9 Kashani A....El Mestikawy S. (2008)
    9. Distribution of vesicular glutamate transporter 2 (VGl uT2) in the primary visual cortex of the macaque and human. (PubMed id 22684983)1 Garcia-Marin V....Hawken M.J. (2013)
    10. Identification of risk loci with shared effects on fiv e major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1  ....Sullivan P.F. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57084 HGNC: 16703 AceView: SLC17A6 Ensembl:ENSG00000091664 euGenes: HUgn57084
    ECgene: SLC17A6 Kegg: 57084 H-InvDB: SLC17A6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC17A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC17A6 gene:
    Search GeneIP for patents involving SLC17A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC17A6  
     OriGene qPCR primer pairs and template standards for SLC17A6   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC17A6  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC17A6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC17A6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC17A6   OriGene Custom Protein Services for SLC17A6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC17A6
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC17A6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC17A6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC17A6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC17A6
     GenScript Custom Purified and Recombinant Proteins Services for SLC17A6 GenScript cDNA clones with any tag delivered in your preferred vector for SLC17A6
     GenScript Custom Assay Services for SLC17A6 GenScript Custom Superior Antibodies Services for SLC17A6
     GenScript Custom overexpressing Cell Line Services for SLC17A6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SLC17A6 

     Regulatory tfbs in SLC17A6 promoter
     Search Chromatin IP Primers for SLC17A6
     RT2 qPCR Primer Assay in human, mouse, rat SLC17A6
     Search GNC Networks for SLC17A6
     SABiosciences PCR Arrays including human, mouse, rat SLC17A6
     Search Tocris compounds for SLC17A6 (VGLU2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC17A6 antibodies
     Antibodies for SLC17A6
     See all of Abcam's Antibodies, Kits and Proteins for SLC17A6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC17A6
     Antibodies for SLC17A6
     ELISAs for SLC17A6
     CLIAs for SLC17A6
     Search LifeMap BioReagents cell lines for SLC17A6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A6
     SwitchGear 3'UTR luciferase reporter plasmids for SLC17A6
     SwitchGear Promoter luciferase reporter plasmids for SLC17A6
     ThermoFisher Antibodies for SLC17A6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC17A6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC17A6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC17A6
    Customized:
     lentivirus for stable overexpression of SLC17A6
     lentivirus expression plasmids for stable overexpression of SLC17A6
     adenovirus for overexpression of SLC17A6
     LSBio Antibodies in human, mouse, rat for SLC17A6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC17A6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4