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Aliases for SLC17A6 Gene

Aliases for SLC17A6 Gene

  • Solute Carrier Family 17 Member 6 2 3 4 5
  • Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 6 2 3
  • Differentiation-Associated Na(+)-Dependent Inorganic Phosphate Cotransporter 3 4
  • Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter 2 3
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 2 3
  • Vesicular Glutamate Transporter 2 2 3
  • Differentiation-Associated BNPI 3 4
  • VGLUT2 3 4
  • DNPI 3 4

External Ids for SLC17A6 Gene

Previous GeneCards Identifiers for SLC17A6 Gene

  • GC11P023776
  • GC11P023161
  • GC11P022398
  • GC11P022323
  • GC11P022316
  • GC11P022042

Summaries for SLC17A6 Gene

GeneCards Summary for SLC17A6 Gene

SLC17A6 (Solute Carrier Family 17 Member 6) is a Protein Coding gene. Diseases associated with SLC17A6 include Gnathodiaphyseal Dysplasia and Tendinosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neuroscience. GO annotations related to this gene include symporter activity and L-glutamate transmembrane transporter activity. An important paralog of this gene is SLC17A7.

UniProtKB/Swiss-Prot for SLC17A6 Gene

  • Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A6 Gene

Genomics for SLC17A6 Gene

Regulatory Elements for SLC17A6 Gene

Enhancers for SLC17A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G022792 1.4 FANTOM5 Ensembl ENCODE 11.1 +454.5 454505 1.1 FOXA2 RARA CHAMP1 FOS THAP11 ZNF592 KLF16 PBX2 CEBPA RCOR2 SVIP ENSG00000254768 SLC17A6 ENSG00000246225 GC11P022744
GH11G022665 1.4 Ensembl ENCODE dbSUPER 10.1 +329.9 329927 4.6 HDGF TBP FUS WRNIP1 ARID4B DMAP1 ZNF48 YY1 RELB IKZF2 SLC17A6 ENSG00000254768 GAS2 RNA5SP338 FANCF
GH11G022670 1 ENCODE dbSUPER 10.1 +332.9 332913 0.2 GATAD2A CTCF ZNF654 TRIM22 CEBPB CEBPG REST RAD21 CEBPA IKZF1 ENSG00000254768 SLC17A6 RNA5SP338 FANCF
GH11G022787 0.7 ENCODE 11.9 +449.6 449623 0.1 CTCF ZNF654 TEAD4 TRIM22 REST RAD21 ARID3A EGR1 ZNF512 ZNF143 SLC17A6 ENSG00000254768 GC11P022744 ENSG00000246225
GH11G022690 0.4 ENCODE 9.9 +353.0 352968 1.0 NFIC NFIB ENSG00000254768 SLC17A6 RNA5SP338 GC11P022726
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC17A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC17A6 Gene

Chromosome:
11
Start:
22,338,097 bp from pter
End:
22,379,503 bp from pter
Size:
41,407 bases
Orientation:
Plus strand

Genomic View for SLC17A6 Gene

Genes around SLC17A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A6 Gene

Proteins for SLC17A6 Gene

  • Protein details for SLC17A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2U8-VGLU2_HUMAN
    Recommended name:
    Vesicular glutamate transporter 2
    Protein Accession:
    Q9P2U8
    Secondary Accessions:
    • A6NKS2

    Protein attributes for SLC17A6 Gene

    Size:
    582 amino acids
    Molecular mass:
    64392 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC17A6 Gene

Post-translational modifications for SLC17A6 Gene

  • Glycosylation at isoforms=100, Asn101, and isoforms=470
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC17A6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC17A6 Gene

Domains & Families for SLC17A6 Gene

Gene Families for SLC17A6 Gene

Protein Domains for SLC17A6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P2U8

UniProtKB/Swiss-Prot:

VGLU2_HUMAN :
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
genes like me logo Genes that share domains with SLC17A6: view

Function for SLC17A6 Gene

Molecular function for SLC17A6 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Ontology (GO) - Molecular Function for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC17A6: view
genes like me logo Genes that share phenotypes with SLC17A6: view

Animal Models for SLC17A6 Gene

MGI Knock Outs for SLC17A6:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC17A6

CRISPR Products

miRNA for SLC17A6 Gene

miRTarBase miRNAs that target SLC17A6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC17A6 Gene

Localization for SLC17A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A6 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC17A6 gene
Compartment Confidence
plasma membrane 4
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane TAS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SLC17A6: view

Pathways & Interactions for SLC17A6 Gene

genes like me logo Genes that share pathways with SLC17A6: view

Pathways by source for SLC17A6 Gene

Gene Ontology (GO) - Biological Process for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006836 neurotransmitter transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC17A6: view

No data available for SIGNOR curated interactions for SLC17A6 Gene

Drugs & Compounds for SLC17A6 Gene

(2) Drugs for SLC17A6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SLC17A6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC17A6: view

Transcripts for SLC17A6 Gene

mRNA/cDNA for SLC17A6 Gene

Unigene Clusters for SLC17A6 Gene

Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A6 Gene

No ASD Table

Relevant External Links for SLC17A6 Gene

GeneLoc Exon Structure for
SLC17A6
ECgene alternative splicing isoforms for
SLC17A6

Expression for SLC17A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC17A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A6 Gene

This gene is overexpressed in Brain - Hypothalamus (x16.7), Brain - Amygdala (x7.1), Brain - Substantia nigra (x6.7), Brain - Frontal Cortex (BA9) (x5.9), and Pituitary (x4.6).

Protein differential expression in normal tissues from HIPED for SLC17A6 Gene

This gene is overexpressed in Fetal Brain (33.2), Brain (20.8), and Frontal cortex (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC17A6 Gene



Protein tissue co-expression partners for SLC17A6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC17A6 Gene:

SLC17A6

SOURCE GeneReport for Unigene cluster for SLC17A6 Gene:

Hs.242821

mRNA Expression by UniProt/SwissProt for SLC17A6 Gene:

Q9P2U8-VGLU2_HUMAN
Tissue specificity: Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.

Evidence on tissue expression from TISSUES for SLC17A6 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SLC17A6: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC17A6 Gene

Orthologs for SLC17A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A6 34 35
  • 99.83 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC17A6 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC17A6 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A6 34 35
  • 94.79 (n)
dog
(Canis familiaris)
Mammalia SLC17A6 34 35
  • 93.99 (n)
mouse
(Mus musculus)
Mammalia Slc17a6 34 16 35
  • 88.77 (n)
rat
(Rattus norvegicus)
Mammalia Slc17a6 34
  • 87.63 (n)
chicken
(Gallus gallus)
Aves SLC17A6 34 35
  • 84.28 (n)
lizard
(Anolis carolinensis)
Reptilia SLC17A6 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc17a6 34
  • 76.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398748 34
zebrafish
(Danio rerio)
Actinopterygii slc17a6a 34 35
  • 74.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta VGlut 34 35
  • 55.97 (n)
CG9887 36
  • 51 (a)
CG4288 36
  • 41 (a)
CG15096 36
  • 34 (a)
CG3036 36
  • 34 (a)
Picot 36
  • 34 (a)
CG15094 36
  • 33 (a)
CG9826 36
  • 31 (a)
CG9864 36
  • 31 (a)
l(2)08717 36
  • 31 (a)
NaPi-T 36
  • 31 (a)
CG3649 36
  • 30 (a)
CG4726 36
  • 30 (a)
CG9825 36
  • 30 (a)
CG30265 36
  • 29 (a)
CG30272 36
  • 29 (a)
CG2003 36
  • 28 (a)
CG7881 36
  • 28 (a)
CG8791 36
  • 28 (a)
BEST:CK02623 36
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007992 34
  • 53.92 (n)
worm
(Caenorhabditis elegans)
Secernentea eat-4 35
  • 44 (a)
ManyToMany
T07A5.3 36
  • 41 (a)
vglu-3 35
  • 38 (a)
ManyToMany
vglu-2 35
  • 36 (a)
ManyToMany
ZK54.1 36 35
  • 35 (a)
C38C10.2 35
  • 33 (a)
ManyToMany
F21F8.11 36 35
  • 27 (a)
C02C2.4 36 35
  • 26 (a)
F12B6.2a 36
  • 25 (a)
F12B6.2b 36
  • 25 (a)
R10D12.1 36 35
  • 25 (a)
T09B9.2 36 35
  • 25 (a)
K10H10.1 36
  • 24 (a)
cima-1 35
  • 22 (a)
ManyToMany
F25G6.7 35
  • 22 (a)
ManyToMany
Y15E3A.4 35
  • 22 (a)
ManyToMany
Y4C6B.3 35
  • 22 (a)
ManyToMany
T28F3.4 35
  • 21 (a)
ManyToMany
ZK682.2 35
  • 21 (a)
ManyToMany
F12B6.2 35
  • 20 (a)
ManyToMany
F44E7.7 35
  • 20 (a)
ManyToMany
H11E01.2 35
  • 20 (a)
ManyToMany
M162.5 35
  • 20 (a)
ManyToMany
T27D12.1 35
  • 20 (a)
ManyToMany
Y4C6B.4 35
  • 20 (a)
ManyToMany
C01B4.8 35
  • 19 (a)
ManyToMany
T19D12.9 35
  • 19 (a)
ManyToMany
T22F3.10 35
  • 19 (a)
ManyToMany
T22F3.7 35
  • 19 (a)
ManyToMany
Y19D10A.5 35
  • 19 (a)
ManyToMany
Y19D10A.8 35
  • 19 (a)
ManyToMany
C01B4.7 35
  • 18 (a)
ManyToMany
C18D1.2 35
  • 18 (a)
ManyToMany
C35A5.3 35
  • 18 (a)
ManyToMany
F56A4.10 35
  • 18 (a)
ManyToMany
F59A1.13 35
  • 18 (a)
ManyToMany
K11G9.5 35
  • 18 (a)
ManyToMany
M117.1 35
  • 18 (a)
ManyToMany
T19D12.10 35
  • 18 (a)
ManyToMany
T22F3.11 35
  • 18 (a)
ManyToMany
T22F3.8 35
  • 18 (a)
ManyToMany
Y19D10A.4 35
  • 18 (a)
ManyToMany
Y51B9A.6 35
  • 18 (a)
ManyToMany
C18H9.5 35
  • 17 (a)
ManyToMany
F10C2.7 35
  • 17 (a)
ManyToMany
F56A4.12 35
  • 17 (a)
ManyToMany
K08C7.1 35
  • 17 (a)
ManyToMany
T02B11.6 35
  • 17 (a)
ManyToMany
Y19D10A.11 35
  • 17 (a)
ManyToMany
F11A5.9 35
  • 16 (a)
ManyToMany
F41C3.2 35
  • 15 (a)
ManyToMany
W04C9.6 35
  • 15 (a)
ManyToMany
T28H11.8 35
  • 14 (a)
ManyToMany
T01H3.3 35
  • 13 (a)
ManyToMany
C39E9.7 35
  • 12 (a)
ManyToMany
Y19D10A.10 35
  • 12 (a)
ManyToMany
F56A4.11 35
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
OneToMany
Species where no ortholog for SLC17A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC17A6 Gene

ENSEMBL:
Gene Tree for SLC17A6 (if available)
TreeFam:
Gene Tree for SLC17A6 (if available)

Paralogs for SLC17A6 Gene

Paralogs for SLC17A6 Gene

(6) SIMAP similar genes for SLC17A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC17A6: view

Variants for SLC17A6 Gene

Sequence variations from dbSNP and Humsavar for SLC17A6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_038710 A breast cancer sample
rs1000089427 -- 22,342,104(+) TTACT(C/T)GGATG intron-variant
rs1000131253 -- 22,336,605(+) AGATG(A/G)TTTTA upstream-variant-2KB
rs1000139380 -- 22,345,909(+) AAATG(C/T)TACAT intron-variant
rs1000171777 -- 22,372,775(+) CTTAA(A/C)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A6 Gene

Variant ID Type Subtype PubMed ID
esv3357361 CNV insertion 20981092
esv3625615 CNV gain 21293372
nsv1038630 CNV loss 25217958
nsv1041233 CNV gain 25217958
nsv1122588 CNV deletion 24896259
nsv38773 CNV deletion 16902084

Variation tolerance for SLC17A6 Gene

Residual Variation Intolerance Score: 7.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC17A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC17A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A6 Gene

Disorders for SLC17A6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC17A6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gnathodiaphyseal dysplasia
  • gdd, osteogenesis imperfecta with unusual skeletal lesions
tendinosis
colorblindness, tritan
  • tritanopia
blue color blindness
  • tritanopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC17A6

Genetic Association Database (GAD)
SLC17A6
Human Genome Epidemiology (HuGE) Navigator
SLC17A6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC17A6
genes like me logo Genes that share disorders with SLC17A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC17A6 Gene

Publications for SLC17A6 Gene

  1. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). (PMID: 11698620) Takamori S. … Jahn R. (J. Neurosci. 2001) 3 4 22 64
  2. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PMID: 10820226) Aihara Y. … Takeda J. (J. Neurochem. 2000) 3 4 22 64
  3. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. (PMID: 20540360) Lisitskaia K.V. … Shishkin S.S. (Mol. Gen. Mikrobiol. Virusol. 2010) 3 46 64
  4. Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia. (PMID: 20541370) Shen Y.C. … Chen C.H. (Schizophr. Res. 2010) 3 46 64
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64

Products for SLC17A6 Gene

Sources for SLC17A6 Gene

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