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GIFtS

SLC17A6 Gene

protein-coding   GIFtS: 54
GCID: GC11P022316

solute carrier family 17 (sodium-dependent inorganic phosphate...
 Explore 12 diseases affiliated with
SLC17A6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC17A6    

Aliases
for SLC17A6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate
Cotransporter), Member 61 2
     Solute Carrier Family 17 Member 62 3
DNPI1 2 3 5     Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter2
VGLUT21 2 3 5     Vesicular Glutamate Transporter 22
Differentiation-Associated BNPI2 3     VGluT23
Differentiation-Associated Na(+)-Dependent Inorganic Phosphate Cotransporter2 3     

External Ids:    HGNC: 167031   Entrez Gene: 570842   Ensembl: ENSG000000916647   OMIM: 6075635   UniProtKB: Q9P2U83   

Export aliases for SLC17A6 gene to outside databases

Previous GC identifers: GC11P023776 GC11P023161 GC11P022398 GC11P022323 GC11P022042


Summaries
for SLC17A6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8
Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural
cells. May also mediate the transport of inorganic phosphate




Genomic Views
for SLC17A6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC17A6 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-2   Pax-2a   E2F-2   E2F   E2F-1   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC17A6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC17A6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.3   Ensembl cytogenetic band:  11p14.3   HGNC cytogenetic band: 11p14.3

SLC17A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P022316:  view genomic region     (about GC identifiers)

Start:
 22,359,643 bp from pter      End:
 22,401,049 bp from pter
Size:
 41,407 bases      Orientation:
 plus strand

Proteins
for SLC17A6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8 (See protein sequence)
Recommended Name: Vesicular glutamate transporter 2  
Size: 582 amino acids; 64392 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane;
Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity)
Developmental stage: Expressed in fetal brain
Secondary accessions: A6NKS2

Explore the universe of human proteins at neXtProt for SLC17A6: NX_Q9P2U8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2U8

    • SLC17A6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065079.1  
    ENSEMBL proteins: 
     ENSP00000263160  
    Reactome Protein details: Q9P2U8
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC17A6

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome ----
    GO:0008021synaptic vesicle ----
    GO:0016021integral to membrane IEA--
    GO:0019717synaptosome ----
    GO:0030054cell junction IEA--


    SLC17A6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC17A6

    Protein Domains /
    Families
    for SLC17A6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC17A6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9P2U8

    ProtoNet protein and cluster: Q9P2U8

    UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8
    Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily


    Function
    for SLC17A6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8
    Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural
    cells. May also mediate the transport of inorganic phosphate

    miRNA
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    hsa-miR-137 hsa-miR-200a hsa-miR-25 hsa-miR-519a hsa-miR-218 hsa-miR-141 hsa-miR-4325 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: SLC17A6 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005313L-glutamate transmembrane transporter activity IEA--
    GO:0015293symporter activity IEA--


    SLC17A6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SLC17A6: Slc17a6tm1.1Lowl Slc17a6tm1.2Edw Slc17a6tm1Lex Slc17a6tm1.1Kldr
         10 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Slc17a6):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  integument 
     mortality/aging  nervous system  no phenotypic analysis  normal  respiratory system 

    SLC17A6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC17A6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Organic anion transporters
    		Organic anion transporters1.00
    4Glutamic acid signaling
    		Glutamic acid signaling1.00
    5Synaptic Vesicle Pathway
    		Synaptic Vesicle Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLC17A6
        Glutamic acid signaling


    1 BioSystems Pathway for SLC17A6 
        Synaptic Vesicle Pathway

    5        Reactome Pathways for SLC17A6
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides
    Organic anion transporters


    1         Kegg Pathway  (Kegg details for SLC17A6):
        Glutamatergic synapse


    SLC17A6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC17A6

    2 Interacting proteins for SLC17A6 (Q9P2U83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSKP432353I2D: score=1 
    TUBA1AQ71U363I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001504neurotransmitter uptake IEA--
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0015813L-glutamate transport ----
    GO:0055085transmembrane transport TAS--


    SLC17A6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC17A6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC17A6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC17A6

    1 HMDB Compound for SLC17A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--
    6 Novoseek chemical compound relationships for SLC17A6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 77 73 11985876 (3), 11432869 (3), 11551935 (3), 11698620 (3) (see all 38)
    gaba 49.4 8 11698620 (3), 16516863 (1), 16546297 (1), 18611437 (1) (see all 5)
    chloride 5.76 1 11432869 (1)
    atp 0 1 11432869 (1)
    glucose 0 1 12444014 (1)
    hydrogen 0 1 11432869 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC17A6 / VGLU2 

    Transcripts
    for SLC17A6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC17A6 gene: 
    NM_020346.2  

    Unigene Cluster for SLC17A6:

    Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
    Hs.242821  [show with all ESTs]
    Unigene Representative Sequence: AB032435
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263160(uc001mqk.3) ENST00000534115

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC17A6 (see all 23):
    hsa-miR-137 hsa-miR-200a hsa-miR-25 hsa-miR-519a hsa-miR-218 hsa-miR-141 hsa-miR-4325 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: SLC17A6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC17A6 (see all 7)
    OriGene shRNA RFP: SLC17A6
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC17A6
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB032435.1 AK294502.1 AK309131.1 BC069629.1 BC069640.1 BC069646.1 

    2 DOTS entries:

    DT.75113177  DT.120747006 

    24/25 AceView cDNA sequences (see all 25):

    BP361419 BC069640 BQ185289 BC069646 BQ188116 CK823303 BM966897 BC069629 
    BP361657 AB032435 BP362340 BP359897 NM_020346 BP362646 AL119976 BP361895 
    BM273076 BP361810 BM893652 CK823302 BP361755 BP361488 AW128878 BF369840 

    GeneLoc Exon Structure


    Expression
    for SLC17A6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC17A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCATACACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC17A6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainHypothalamusBrain
    EyeRetinaEye
    Neural TubeDiencephalonNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC17A6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC17A6

    SOURCE GeneReport for Unigene cluster: Hs.242821

    UniProtKB/Swiss-Prot: VGLU2_HUMAN, Q9P2U8
    Tissue specificity: Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex,
    frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus,
    temporal lobe and thalamus

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC17A6: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A6

    Orthologs
    for SLC17A6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC17A6 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC17A61 solute carrier family 17 (sodium-dependent inorganic more 84.28(n)
    94.66(a)    		   422971  NM_001168383.1  NP_001161855.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC17A66
    		 --
    		 94(a)
    		 1 ↔ 1
    		 1(58641482-58699160)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3987482 glutamate transporter 76.58(n)    AF548627.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii slc17a6a1 solute carrier family 17 (sodium-dependent inorganic more 74.39(n)
    86.41(a)    		   494492  NM_001009982.1  NP_001009982.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG98873
    VGlut1    		 high affinity inorganic phosphate:sodium
    symporter3
    Vesicular glutamate transporter1    		 51(a)
    (best of 19)3
    57.65(n)1
    54.36(a)1    		   334271  NM_134837.31  NP_608681.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea T07A5.33 sodium/phosphate transporter protein 41(a)
    (best of 9)    		   III(10372084-10374948)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PHT4;66
    		 putative anion transporter 5
    		 30(a)
    		 1 → many
    		 5(17874885-17877564)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 transporter, major facilitator family, putative, e...
    transporter, major facilitator family, putative, e...
    		 29(a)
    29(a)
    		 many ↔ many
    many ↔ many
    		 11(4409142-4411772)
    12(4043466-4046391)


    ENSEMBL Gene Tree for SLC17A6 (if available)
    TreeFam Gene Tree for SLC17A6 (if available) 

    Paralogs
    for SLC17A6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC17A6 gene
    SLC17A72  SLC17A82  SLC17A32  SLC17A42  SLC17A12  SLC17A52  SLC17A92  SLC17A22  
    6 SIMAP similar genes for SLC17A6 using alignment to 3 protein entries:     VGLU2_HUMAN (see all proteins):
    SLC17A7    SLC17A8    SLC17A5    SLC17A4    SLC17A2    SLC17A1

    SLC17A6 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC17A6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/907 NCBI SNPs in SLC17A6 are shown (see all 907)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1922298861,2
    		--22357693(+) AATCAC/TTTACA 1 -- us2k10--------
    rs800399341,2
    		F,--22357739(+) ATTCTA/GTTTTT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1843321951,2
    		--22357756(+) AACTTC/TCCAGA 1 -- us2k10--------
    rs669448371,2
    		C,--22357801(+) ATTTAT/ATGAAC 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs1460201971,2
    		--22357826(+) TTTGAA/GAAATA 1 -- us2k10--------
    rs14475151,2
    		C,F,A,H,--22357886(-) AAGATT/GAAAAG 1 -- us2k1 tfbs38Minor allele frequency- G:0.21MN EA NS WA CSA NA 593
    rs1486934411,2
    		--22357944(+) TTTTTG/TGTCTC 1 -- us2k10--------
    rs747486781,2
    		F,--22357959(+) TACTTG/CATCTT 1 -- us2k11Minor allele frequency- C:0.25EA 120
    rs1811141271,2
    		--22357961(+) CTTGAC/TCTTGA 1 -- us2k10--------
    rs765162551,2
    		C,F,--22358076(+) AATGTC/TTTCAT 1 -- us2k11Minor allele frequency- T:0.24WA 118

    HapMap Linkage Disequilibrium report for SLC17A6 (22359643 - 22401049 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC17A6: --

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    Disorders / Diseases
    for SLC17A6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC17A6 for disorders           About GeneDecksing

    OMIM gene information: 607563    OMIM disorders: --

    12 diseases for SLC17A6:    About MalaCards
    gnathodiaphyseal dysplasia    major depressive disorder    bipolar disorder    parkinson's disease
    cholera    alzheimer's disease    schizophrenia    prostate cancer
    cerebritis    prostatitis    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC17A6:
    Cholera

    1 Novoseek disease relationship for SLC17A6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 0 1 15653259 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC17A6 (4 documents)

    Export disorders for SLC17A6 gene to outside databases

    Publications
    for SLC17A6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC17A6 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with SLC17A6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PubMed id 10820226)1, 2, 9 Aihara Y....Takeda J. (2000)
    2. Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3. (PubMed id 11306821)1, 3 Aihara Y....Takeda J. (2001)
    3. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). (PubMed id 11698620)2, 9 Takamori S....Jahn R. (2001)
    4. Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. (PubMed id 17531353)1, 9 Kashani A....El Mestikawy S. (2008)
    5. Glutamatergic and GABAergic innervation of human gonad otropin-releasing hormone-I neurons. (PubMed id 22510271)1 Hrabovszky E....Liposits Z. (2012)
    6. Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia. (PubMed id 20541370)1 Shen Y.C....Chen C.H. (2010)
    7. [A study of the single nucleotide polymorphism in sev en genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer] (PubMed id 20540360)1 Lisitskaia K.V....Shishkin S.S. (2010)
    8. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1 Need A.C....Goldstein D.B. (2009)
    9. Vesicular glutamate transporter mRNA expression in th e medial temporal lobe in major depressive disorder, bipolar disorder, and schi zophrenia. (PubMed id 19839996)1 Uezato A....McCullumsmith R.E. (2009)
    10. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. (PubMed id 18050306)1 Scott A....Forsgren S. (2008)

    External Searches for SLC17A6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC17A6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57084 HGNC: 16703 AceView: SLC17A6 Ensembl:ENSG00000091664 euGenes: HUgn57084
    ECgene: SLC17A6 Kegg: 57084 H-InvDB: SLC17A6

    Other Databases showing SLC17A6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC17A6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC17A6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC17A6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC17A6 gene:
    Search GeneIP for patents involving SLC17A6

    GeneCards and IP:
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