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Aliases for SLC17A6 Gene

Aliases for SLC17A6 Gene

  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 2 3
  • VGLUT2 3 4 6
  • DNPI 3 4 6
  • Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 6 2 3
  • Differentiation-Associated Na(+)-Dependent Inorganic Phosphate Cotransporter 3 4
  • Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter 2 3
  • Vesicular Glutamate Transporter 2 2 3
  • Solute Carrier Family 17 Member 6 3 4
  • Differentiation-Associated BNPI 3 4

External Ids for SLC17A6 Gene

Previous GeneCards Identifiers for SLC17A6 Gene

  • GC11P023776
  • GC11P023161
  • GC11P022398
  • GC11P022323
  • GC11P022316
  • GC11P022042

Summaries for SLC17A6 Gene

GeneCards Summary for SLC17A6 Gene

SLC17A6 (Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6) is a Protein Coding gene. Diseases associated with SLC17A6 include gnathodiaphyseal dysplasia and tendinosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Neuroscience. GO annotations related to this gene include symporter activity and L-glutamate transmembrane transporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A6 Gene

  • Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A6 Gene

Genomics for SLC17A6 Gene

Regulatory Elements for SLC17A6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC17A6 Gene

Start:
22,338,097 bp from pter
End:
22,379,503 bp from pter
Size:
41,407 bases
Orientation:
Plus strand

Genomic View for SLC17A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC17A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A6 Gene

Proteins for SLC17A6 Gene

  • Protein details for SLC17A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2U8-VGLU2_HUMAN
    Recommended name:
    Vesicular glutamate transporter 2
    Protein Accession:
    Q9P2U8
    Secondary Accessions:
    • A6NKS2

    Protein attributes for SLC17A6 Gene

    Size:
    582 amino acids
    Molecular mass:
    64392 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC17A6 Gene

Proteomics data for SLC17A6 Gene at MOPED

Post-translational modifications for SLC17A6 Gene

  • Glycosylation at Asn100, Asn101, and Asn470
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC17A6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC17A6 (SLC17A6)

No data available for DME Specific Peptides for SLC17A6 Gene

Domains for SLC17A6 Gene

Gene Families for SLC17A6 Gene

Protein Domains for SLC17A6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P2U8

UniProtKB/Swiss-Prot:

VGLU2_HUMAN :
  • Q9P2U8
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
genes like me logo Genes that share domains with SLC17A6: view

Function for SLC17A6 Gene

Molecular function for SLC17A6 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Gene Ontology (GO) - Molecular Function for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC17A6: view
genes like me logo Genes that share phenotypes with SLC17A6: view

Animal Models for SLC17A6 Gene

MGI Knock Outs for SLC17A6:

Animal Model Products

CRISPR Products

miRNA for SLC17A6 Gene

miRTarBase miRNAs that target SLC17A6

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC17A6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC17A6 Gene

Localization for SLC17A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A6 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A6 Gene COMPARTMENTS Subcellular localization image for SLC17A6 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane TAS --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with SLC17A6: view

Pathways for SLC17A6 Gene

genes like me logo Genes that share pathways with SLC17A6: view

Pathways by source for SLC17A6 Gene

PCR Array Products

Interacting Proteins for SLC17A6 Gene

Gene Ontology (GO) - Biological Process for SLC17A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001504 neurotransmitter uptake IEA --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0015813 L-glutamate transport --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC17A6: view

Compounds for SLC17A6 Gene

(1) HMDB Compounds for SLC17A6 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(6) Novoseek inferred chemical compound relationships for SLC17A6 Gene

Compound -log(P) Hits PubMed IDs
glutamate 77 56
gaba 49.4 7
chloride 5.76 1
atp 0 1
glucose 0 1
genes like me logo Genes that share compounds with SLC17A6: view

Transcripts for SLC17A6 Gene

mRNA/cDNA for SLC17A6 Gene

Unigene Clusters for SLC17A6 Gene

Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC17A6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A6 Gene

No ASD Table

Relevant External Links for SLC17A6 Gene

GeneLoc Exon Structure for
SLC17A6
ECgene alternative splicing isoforms for
SLC17A6

Expression for SLC17A6 Gene

mRNA expression in normal human tissues for SLC17A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC17A6 Gene

This gene is overexpressed in Brain - Hypothalamus (16.7), Brain - Amygdala (7.1), Brain - Substantia nigra (6.7), Brain - Frontal Cortex (BA9) (5.9), and Pituitary (4.6).

Protein differential expression in normal tissues for SLC17A6 Gene

This gene is overexpressed in Fetal Brain (33.2), Brain (20.8), and Frontal cortex (12.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC17A6 Gene

SOURCE GeneReport for Unigene cluster for SLC17A6 Gene Hs.242821

mRNA Expression by UniProt/SwissProt for SLC17A6 Gene

Q9P2U8-VGLU2_HUMAN
Tissue specificity: Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.
genes like me logo Genes that share expressions with SLC17A6: view

Expression partners for SLC17A6 Gene

In Situ Assay Products

Orthologs for SLC17A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC17A6 35
  • 94.79 (n)
  • 98.28 (a)
SLC17A6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC17A6 35
  • 93.99 (n)
  • 98.63 (a)
SLC17A6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a6 35
  • 88.77 (n)
  • 97.42 (a)
Slc17a6 16
Slc17a6 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC17A6 35
  • 99.83 (n)
  • 100 (a)
SLC17A6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc17a6 35
  • 87.63 (n)
  • 97.59 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC17A6 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC17A6 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC17A6 35
  • 84.28 (n)
  • 94.66 (a)
SLC17A6 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC17A6 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc17a6 35
  • 76.76 (n)
  • 90.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398748 35
zebrafish
(Danio rerio)
Actinopterygii slc17a6a 35
  • 74.39 (n)
  • 86.41 (a)
slc17a6a 36
  • 86 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK02623 37
  • 26 (a)
CG15094 37
  • 33 (a)
CG15096 37
  • 34 (a)
CG2003 37
  • 28 (a)
CG30265 37
  • 29 (a)
CG30272 37
  • 29 (a)
CG3036 37
  • 34 (a)
CG3649 37
  • 30 (a)
CG4288 37
  • 41 (a)
CG4726 37
  • 30 (a)
CG7881 37
  • 28 (a)
CG8791 37
  • 28 (a)
CG9825 37
  • 30 (a)
CG9826 37
  • 31 (a)
CG9864 37
  • 31 (a)
CG9887 37
  • 51 (a)
l(2)08717 37
  • 31 (a)
NaPi-T 37
  • 31 (a)
Picot 37
  • 34 (a)
VGlut 35
  • 55.97 (n)
  • 50.93 (a)
VGlut 36
  • 41 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007992 35
  • 53.92 (n)
  • 52.24 (a)
worm
(Caenorhabditis elegans)
Secernentea C02C2.4 37
  • 26 (a)
F12B6.2a 37
  • 25 (a)
F12B6.2b 37
  • 25 (a)
F21F8.11 37
  • 27 (a)
K10H10.1 37
  • 24 (a)
R10D12.1 37
  • 25 (a)
T07A5.3 37
  • 41 (a)
T09B9.2 37
  • 25 (a)
ZK54.1 37
  • 35 (a)
C01B4.7 36
  • 18 (a)
ManyToMany
C01B4.8 36
  • 19 (a)
ManyToMany
C02C2.4 36
  • 20 (a)
ManyToMany
C18D1.2 36
  • 18 (a)
ManyToMany
C18H9.5 36
  • 17 (a)
ManyToMany
C35A5.3 36
  • 18 (a)
ManyToMany
C38C10.2 36
  • 33 (a)
ManyToMany
C39E9.7 36
  • 12 (a)
ManyToMany
cima-1 36
  • 22 (a)
ManyToMany
eat-4 36
  • 44 (a)
ManyToMany
F10C2.7 36
  • 17 (a)
ManyToMany
F11A5.9 36
  • 16 (a)
ManyToMany
F12B6.2 36
  • 20 (a)
ManyToMany
F21F8.11 36
  • 22 (a)
ManyToMany
F25G6.7 36
  • 22 (a)
ManyToMany
F41C3.2 36
  • 15 (a)
ManyToMany
F44E7.7 36
  • 20 (a)
ManyToMany
F56A4.10 36
  • 18 (a)
ManyToMany
F56A4.11 36
  • 11 (a)
ManyToMany
F56A4.12 36
  • 17 (a)
ManyToMany
F59A1.13 36
  • 18 (a)
ManyToMany
H11E01.2 36
  • 20 (a)
ManyToMany
K08C7.1 36
  • 17 (a)
ManyToMany
K11G9.5 36
  • 18 (a)
ManyToMany
M117.1 36
  • 18 (a)
ManyToMany
M162.5 36
  • 20 (a)
ManyToMany
R10D12.1 36
  • 22 (a)
ManyToMany
T01H3.3 36
  • 13 (a)
ManyToMany
T02B11.6 36
  • 17 (a)
ManyToMany
T09B9.2 36
  • 23 (a)
ManyToMany
T19D12.10 36
  • 18 (a)
ManyToMany
T19D12.9 36
  • 19 (a)
ManyToMany
T22F3.10 36
  • 19 (a)
ManyToMany
T22F3.11 36
  • 18 (a)
ManyToMany
T22F3.7 36
  • 19 (a)
ManyToMany
T22F3.8 36
  • 18 (a)
ManyToMany
T27D12.1 36
  • 20 (a)
ManyToMany
T28F3.4 36
  • 21 (a)
ManyToMany
T28H11.8 36
  • 14 (a)
ManyToMany
vglu-2 36
  • 36 (a)
ManyToMany
vglu-3 36
  • 38 (a)
ManyToMany
W04C9.6 36
  • 15 (a)
ManyToMany
Y15E3A.4 36
  • 22 (a)
ManyToMany
Y19D10A.10 36
  • 12 (a)
ManyToMany
Y19D10A.11 36
  • 17 (a)
ManyToMany
Y19D10A.4 36
  • 18 (a)
ManyToMany
Y19D10A.5 36
  • 19 (a)
ManyToMany
Y19D10A.8 36
  • 19 (a)
ManyToMany
Y4C6B.3 36
  • 22 (a)
ManyToMany
Y4C6B.4 36
  • 20 (a)
ManyToMany
Y51B9A.6 36
  • 18 (a)
ManyToMany
ZK54.1 36
  • 36 (a)
ManyToMany
ZK682.2 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for SLC17A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC17A6 Gene

ENSEMBL:
Gene Tree for SLC17A6 (if available)
TreeFam:
Gene Tree for SLC17A6 (if available)

Paralogs for SLC17A6 Gene

Paralogs for SLC17A6 Gene

Selected SIMAP similar genes for SLC17A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC17A6: view

Variants for SLC17A6 Gene

Sequence variations from dbSNP and Humsavar for SLC17A6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs764021 -- 22,371,578(+) GATAC(C/T)GACAG intron-variant
rs764022 -- 22,371,611(+) GGGGG(C/G)AGAGT intron-variant
rs764023 -- 22,371,650(+) GTGTG(A/G/T)TCATT intron-variant
rs921166 -- 22,353,418(-) TGTAG(A/G)CATTT intron-variant
rs930635 -- 22,369,203(-) TAAAA(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A6 Gene

Variant ID Type Subtype PubMed ID
nsv897052 CNV Gain 21882294
nsv38773 CNV Loss 16902084

Relevant External Links for SLC17A6 Gene

HapMap Linkage Disequilibrium report
SLC17A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A6 Gene

Disorders for SLC17A6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC17A6 Gene in MalaCards »

(3) Diseases for SLC17A6 Gene including...

(1) University of Copenhagen DISEASES for SLC17A6 Gene

(1) Novoseek inferred disease relationships for SLC17A6 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 0 1

Relevant External Links for SLC17A6

Genetic Association Database (GAD)
SLC17A6
Human Genome Epidemiology (HuGE) Navigator
SLC17A6
genes like me logo Genes that share disorders with SLC17A6: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SLC17A6 Gene

Publications for SLC17A6 Gene

  1. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. (PMID: 10820226) Aihara Y. … Takeda J. (J. Neurochem. 2000) 3 4 23
  2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 48
  4. Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3. (PMID: 11306821) Aihara Y. … Takeda J. (Cytogenet. Cell Genet. 2001) 2 3
  5. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. (PMID: 20540360) Lisitskaia K.V. … Shishkin S.S. (Mol. Gen. Mikrobiol. Virusol. 2010) 3 48

Products for SLC17A6 Gene

Sources for SLC17A6 Gene

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