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Aliases for SLC17A4 Gene

Aliases for SLC17A4 Gene

  • Solute Carrier Family 17, Member 4 2 3
  • Solute Carrier Family 17 (Sodium Phosphate), Member 4 2 3
  • Putative Small Intestine Sodium-Dependent Phosphate Transport Protein 3
  • Probable Small Intestine Urate Exporter 3
  • Solute Carrier Family 17 Member 4 4
  • Na/PO4 Cotransporter 3
  • KAIA2138 3

External Ids for SLC17A4 Gene

Summaries for SLC17A4 Gene

Entrez Gene Summary for SLC17A4 Gene

  • Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC17A4 Gene

SLC17A4 (Solute Carrier Family 17, Member 4) is a Protein Coding gene. GO annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A4 Gene

  • Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A4 Gene

Genomics for SLC17A4 Gene

Genomic Location for SLC17A4 Gene

Start:
25,754,699 bp from pter
End:
25,781,191 bp from pter
Size:
26,493 bases
Orientation:
Plus strand

Genomic View for SLC17A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC17A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A4 Gene

Regulatory Elements for SLC17A4 Gene

Proteins for SLC17A4 Gene

  • Protein details for SLC17A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C5-S17A4_HUMAN
    Recommended name:
    Probable small intestine urate exporter
    Protein Accession:
    Q9Y2C5
    Secondary Accessions:
    • B4DDV9
    • E7EPE8
    • E7EU17
    • Q32MB7
    • Q32MB8

    Protein attributes for SLC17A4 Gene

    Size:
    497 amino acids
    Molecular mass:
    54055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC17A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A4 Gene

Proteomics data for SLC17A4 Gene at MOPED

Post-translational modifications for SLC17A4 Gene

  • Glycosylation at Asn47, Asn56, Asn66, Asn75, and Asn90

Other Protein References for SLC17A4 Gene

No data available for DME Specific Peptides for SLC17A4 Gene

Domains for SLC17A4 Gene

Gene Families for SLC17A4 Gene

Protein Domains for SLC17A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC17A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2C5

UniProtKB/Swiss-Prot:

S17A4_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.:
    • Q9Y2C5
genes like me logo Genes that share domains with SLC17A4: view

Function for SLC17A4 Gene

Molecular function for SLC17A4 Gene

GENATLAS Biochemistry: solute carrier family(sodium/phosphate cotransport),member 4
UniProtKB/Swiss-Prot Function: Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).

Gene Ontology (GO) - Molecular Function for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005436 sodium:phosphate symporter activity TAS 10319585
genes like me logo Genes that share ontologies with SLC17A4: view

Phenotypes for SLC17A4 Gene

GenomeRNAi human phenotypes for SLC17A4:
genes like me logo Genes that share phenotypes with SLC17A4: view

miRNA for SLC17A4 Gene

miRTarBase miRNAs that target SLC17A4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC17A4 Gene

Localization for SLC17A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A4 Gene

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Apical in the intestinal brush border.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A4 Gene COMPARTMENTS Subcellular localization image for SLC17A4 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10319585
GO:0016020 membrane TAS 10319585
GO:0016021 integral component of membrane --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC17A4: view

Pathways for SLC17A4 Gene

SuperPathways for SLC17A4 Gene

No Data Available

Interacting Proteins for SLC17A4 Gene

Gene Ontology (GO) - Biological Process for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 10319585
GO:0006814 sodium ion transport TAS 10319585
GO:0035435 phosphate ion transmembrane transport TAS 10319585
GO:0035725 sodium ion transmembrane transport TAS 10319585
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC17A4: view

No data available for Pathways by source for SLC17A4 Gene

Compounds for SLC17A4 Gene

(1) HMDB Compounds for SLC17A4 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC17A4: view

Transcripts for SLC17A4 Gene

mRNA/cDNA for SLC17A4 Gene

Unigene Clusters for SLC17A4 Gene

Solute carrier family 17 (sodium phosphate), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: - -
SP3:

Relevant External Links for SLC17A4 Gene

GeneLoc Exon Structure for
SLC17A4
ECgene alternative splicing isoforms for
SLC17A4

Expression for SLC17A4 Gene

mRNA expression in normal human tissues for SLC17A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC17A4 Gene

This gene is overexpressed in Liver (18.2), Colon - Transverse (12.3), Pancreas (11.9), and Small Intestine - Terminal Ileum (6.6).

SOURCE GeneReport for Unigene cluster for SLC17A4 Gene Hs.282931

mRNA Expression by UniProt/SwissProt for SLC17A4 Gene

Q9Y2C5-S17A4_HUMAN
Tissue specificity: Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs.
genes like me logo Genes that share expressions with SLC17A4: view

No data available for Protein expression for SLC17A4 Gene

Orthologs for SLC17A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A4 35
  • 99.53 (n)
  • 99.8 (a)
SLC17A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A4 35
  • 80.76 (n)
  • 70.42 (a)
SLC17A4 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC17A4 35
  • 80.8 (n)
  • 70.12 (a)
SLC17A4 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a4 35
  • 82.52 (n)
  • 79.07 (a)
Slc17a4 16
Slc17a4 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc17a4 35
  • 82.49 (n)
  • 79.39 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3649 37
  • 29 (a)
CG8791 37
  • 31 (a)
CG9825 37
  • 27 (a)
CG7881 37
  • 27 (a)
CG2003 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK682.2 37
  • 25 (a)
T09B9.2 37
  • 25 (a)
F21F8.11 37
  • 26 (a)
Species with no ortholog for SLC17A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC17A4 Gene

ENSEMBL:
Gene Tree for SLC17A4 (if available)
TreeFam:
Gene Tree for SLC17A4 (if available)

Paralogs for SLC17A4 Gene

Paralogs for SLC17A4 Gene

Selected SIMAP similar genes for SLC17A4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC17A4: view

Variants for SLC17A4 Gene

Sequence variations from dbSNP and Humsavar for SLC17A4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1141034 -- 25,780,104(-) ATTTG(A/G)AGTGA utr-variant-3-prime
rs1317510 -- 25,778,696(-) TAAGC(A/G)TTTGC intron-variant
rs1317816 -- 25,765,162(-) TTTGC(A/G)CAAAC intron-variant
rs1317817 -- 25,765,149(-) ATTTA(C/T)GTAGG intron-variant
rs1318016 -- 25,764,476(+) TTCCA(A/T)CTAGA intron-variant

Relevant External Links for SLC17A4 Gene

HapMap Linkage Disequilibrium report
SLC17A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC17A4 Gene

Disorders for SLC17A4 Gene

Relevant External Links for SLC17A4

Genetic Association Database (GAD)
SLC17A4
Human Genome Epidemiology (HuGE) Navigator
SLC17A4
genes like me logo Genes that share disorders with SLC17A4: view

No data available for UniProtKB/Swiss-Prot for SLC17A4 Gene

Publications for SLC17A4 Gene

  1. Isolation and chromosomal mapping of a novel human gene showing homology to Na+/PO4 cotransporter. (PMID: 10319585) Shibui A. … Sugano S. (J. Hum. Genet. 1999) 2 3 4
  2. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. (PMID: 21909108) Bis J.C. … O'Donnell C.J. (Nat. Genet. 2011) 3 48
  3. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PMID: 21943158) Middelberg R.P. … Whitfield J.B. (BMC Med. Genet. 2011) 3 48
  4. A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. (PMID: 22460716) Togawa N. … Moriyama Y. (Am. J. Physiol., Cell Physiol. 2012) 3 4
  5. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3

Products for SLC17A4 Gene

Sources for SLC17A4 Gene

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