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Aliases for SLC17A4 Gene

Aliases for SLC17A4 Gene

  • Solute Carrier Family 17 Member 4 2 3 4
  • Solute Carrier Family 17 (Sodium Phosphate), Member 4 2 3
  • Solute Carrier Family 17, Member 4 2 5
  • Putative Small Intestine Sodium-Dependent Phosphate Transport Protein 3
  • Na/PO4 Cotransporter 3
  • KAIA2138 3

External Ids for SLC17A4 Gene

Previous GeneCards Identifiers for SLC17A4 Gene

  • GC06P025812
  • GC06P025862
  • GC06P025697
  • GC06P025754
  • GC06P025766

Summaries for SLC17A4 Gene

Entrez Gene Summary for SLC17A4 Gene

  • Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC17A4 Gene

SLC17A4 (Solute Carrier Family 17 Member 4) is a Protein Coding gene. GO annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A4 Gene

  • Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A4 Gene

Genomics for SLC17A4 Gene

Regulatory Elements for SLC17A4 Gene

Genomic Location for SLC17A4 Gene

Chromosome:
6
Start:
25,753,359 bp from pter
End:
25,781,191 bp from pter
Size:
27,833 bases
Orientation:
Plus strand

Genomic View for SLC17A4 Gene

Genes around SLC17A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A4 Gene

Proteins for SLC17A4 Gene

  • Protein details for SLC17A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C5-S17A4_HUMAN
    Recommended name:
    Probable small intestine urate exporter
    Protein Accession:
    Q9Y2C5
    Secondary Accessions:
    • B4DDV9
    • E7EPE8
    • E7EU17
    • Q32MB7
    • Q32MB8

    Protein attributes for SLC17A4 Gene

    Size:
    497 amino acids
    Molecular mass:
    54055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC17A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A4 Gene

Proteomics data for SLC17A4 Gene at MOPED

Post-translational modifications for SLC17A4 Gene

  • Glycosylation at Asn 47, Asn 56, Asn 66, Asn 75, and Asn 90
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC17A4 Gene

Antibody Products

No data available for DME Specific Peptides for SLC17A4 Gene

Domains & Families for SLC17A4 Gene

Gene Families for SLC17A4 Gene

Protein Domains for SLC17A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC17A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2C5

UniProtKB/Swiss-Prot:

S17A4_HUMAN :
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
genes like me logo Genes that share domains with SLC17A4: view

Function for SLC17A4 Gene

Molecular function for SLC17A4 Gene

GENATLAS Biochemistry:
solute carrier family(sodium/phosphate cotransport),member 4
UniProtKB/Swiss-Prot Function:
Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).
genes like me logo Genes that share phenotypes with SLC17A4: view

Animal Model Products

CRISPR Products

miRNA for SLC17A4 Gene

miRTarBase miRNAs that target SLC17A4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC17A4 Gene

Localization for SLC17A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A4 Gene

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Apical in the intestinal brush border.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A4 Gene COMPARTMENTS Subcellular localization image for SLC17A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10319585
genes like me logo Genes that share ontologies with SLC17A4: view

Pathways & Interactions for SLC17A4 Gene

SuperPathways for SLC17A4 Gene

No Data Available

Interacting Proteins for SLC17A4 Gene

Gene Ontology (GO) - Biological Process for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 10319585
GO:0035435 phosphate ion transmembrane transport TAS 10319585
GO:0035725 sodium ion transmembrane transport TAS 10319585
genes like me logo Genes that share ontologies with SLC17A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC17A4 Gene

Drugs & Compounds for SLC17A4 Gene

(1) Additional Compounds for SLC17A4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC17A4: view

Transcripts for SLC17A4 Gene

mRNA/cDNA for SLC17A4 Gene

Unigene Clusters for SLC17A4 Gene

Solute carrier family 17 (sodium phosphate), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: - -
SP3:

Relevant External Links for SLC17A4 Gene

GeneLoc Exon Structure for
SLC17A4
ECgene alternative splicing isoforms for
SLC17A4

Expression for SLC17A4 Gene

mRNA expression in normal human tissues for SLC17A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC17A4 Gene

This gene is overexpressed in Liver (x18.2), Colon - Transverse (x12.3), Pancreas (x11.9), and Small Intestine - Terminal Ileum (x6.6).

SOURCE GeneReport for Unigene cluster for SLC17A4 Gene Hs.282931

mRNA Expression by UniProt/SwissProt for SLC17A4 Gene

Q9Y2C5-S17A4_HUMAN
Tissue specificity: Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs.
genes like me logo Genes that share expression patterns with SLC17A4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC17A4 Gene

Orthologs for SLC17A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A4 35
  • 99.53 (n)
  • 99.8 (a)
SLC17A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A4 36
  • 68 (a)
OneToOne
SLC17A4 35
  • 80.76 (n)
  • 70.42 (a)
dog
(Canis familiaris)
Mammalia SLC17A4 35
  • 80.8 (n)
  • 70.12 (a)
SLC17A4 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a4 16
Slc17a4 36
  • 79 (a)
OneToOne
Slc17a4 35
  • 82.52 (n)
  • 79.07 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc17a4 35
  • 82.49 (n)
  • 79.39 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2003 37
  • 29 (a)
CG3649 37
  • 29 (a)
CG7881 37
  • 27 (a)
CG8791 37
  • 31 (a)
CG9825 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea F21F8.11 37
  • 26 (a)
T09B9.2 37
  • 25 (a)
ZK682.2 37
  • 25 (a)
Species with no ortholog for SLC17A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC17A4 Gene

ENSEMBL:
Gene Tree for SLC17A4 (if available)
TreeFam:
Gene Tree for SLC17A4 (if available)

Paralogs for SLC17A4 Gene

Paralogs for SLC17A4 Gene

(7) SIMAP similar genes for SLC17A4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC17A4: view

Variants for SLC17A4 Gene

Sequence variations from dbSNP and Humsavar for SLC17A4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11754288 - 25,776,721(+) TCACT(A/G)CCATT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs1317510 -- 25,778,696(-) TAAGC(A/G)TTTGC intron-variant
rs1317816 -- 25,765,162(-) TTTGC(A/G)CAAAC intron-variant
rs1317817 -- 25,765,149(-) ATTTA(C/T)GTAGG intron-variant
rs1318016 -- 25,764,476(+) TTCCA(A/T)CTAGA intron-variant

Variation tolerance for SLC17A4 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC17A4 Gene

HapMap Linkage Disequilibrium report
SLC17A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC17A4 Gene

Disorders for SLC17A4 Gene

Relevant External Links for SLC17A4

Genetic Association Database (GAD)
SLC17A4
Human Genome Epidemiology (HuGE) Navigator
SLC17A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC17A4

No disorders were found for SLC17A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC17A4 Gene

Publications for SLC17A4 Gene

  1. Isolation and chromosomal mapping of a novel human gene showing homology to Na+/PO4 cotransporter. (PMID: 10319585) Shibui A. … Sugano S. (J. Hum. Genet. 1999) 2 3 4 67
  2. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  3. A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. (PMID: 22460716) Togawa N. … Moriyama Y. (Am. J. Physiol., Cell Physiol. 2012) 3
  4. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PMID: 21943158) Middelberg R.P. … Whitfield J.B. (BMC Med. Genet. 2011) 3
  5. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. (PMID: 21909108) Bis J.C. … O'Donnell C.J. (Nat. Genet. 2011) 3

Products for SLC17A4 Gene

Sources for SLC17A4 Gene

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