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Aliases for SLC17A4 Gene

Aliases for SLC17A4 Gene

  • Solute Carrier Family 17 Member 4 2 3 4 5
  • Solute Carrier Family 17 (Sodium Phosphate), Member 4 2 3
  • Putative Small Intestine Sodium-Dependent Phosphate Transport Protein 3
  • Probable Small Intestine Urate Exporter 3
  • Solute Carrier Family 17, Member 4 2
  • Na/PO4 Cotransporter 3
  • KAIA2138 3

External Ids for SLC17A4 Gene

Previous GeneCards Identifiers for SLC17A4 Gene

  • GC06P025812
  • GC06P025862
  • GC06P025697
  • GC06P025754
  • GC06P025766
  • GC06P025771
  • GC06P025776
  • GC06P025781
  • GC06P025789

Summaries for SLC17A4 Gene

Entrez Gene Summary for SLC17A4 Gene

  • Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC17A4 Gene

SLC17A4 (Solute Carrier Family 17 Member 4) is a Protein Coding gene. GO annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A2.

UniProtKB/Swiss-Prot for SLC17A4 Gene

  • Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).

Additional gene information for SLC17A4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A4 Gene

Genomics for SLC17A4 Gene

Regulatory Elements for SLC17A4 Gene

Enhancers for SLC17A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H025958 1.3 ENCODE dbSUPER 9.5 +208.6 208563 6 HDGF PKNOX1 SIN3A ARID4B FEZF1 YY1 ZNF207 SP3 SP5 REST ENSG00000272462 ZNF322 ABT1 GUSBP2 NUP50P2 TRIM38 HMGN4 BTN2A3P BTN3A2 BTN2A1
GH06H025641 1.1 ENCODE dbSUPER 10.7 -111.1 -111121 1 ELF3 FOXA2 RARA SLC30A9 CREM MIXL1 THAP11 MIER2 SSRP1 CEBPA SCGN SLC17A4 CARMIL1 ENSG00000272462 GC06M025617
GH06H025835 1.1 FANTOM5 ENCODE 10.3 +82.6 82648 0 ELF3 DRAP1 ATF1 SAP130 ZSCAN4 ARID4B ZNF644 TEAD3 POLR2A HOMEZ SLC17A3 SLC17A4 BTN3A2 PIR39663 SLC17A1
GH06H025899 0.9 ENCODE 10.7 +146.6 146606 1 ELF3 FOXA2 ATF1 RAD21 ZSCAN9 RARA CREM MIXL1 KAT8 NFIL3 SLC17A4 ENSG00000277410 GC06P025914
GH06H025865 0.8 ENCODE 10.4 +112.9 112859 0 HDAC1 LEF1 ATF1 TBL1XR1 TAL1 ETV1 JUN BACH1 ZNF175 CEBPG ENSG00000272462 SLC17A1 BTN3A2 SLC17A2 SLC17A4 SLC17A3 PIR39663
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC17A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC17A4 Gene

Chromosome:
6
Start:
25,753,359 bp from pter
End:
25,781,191 bp from pter
Size:
27,833 bases
Orientation:
Plus strand

Genomic View for SLC17A4 Gene

Genes around SLC17A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A4 Gene

Proteins for SLC17A4 Gene

  • Protein details for SLC17A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C5-S17A4_HUMAN
    Recommended name:
    Probable small intestine urate exporter
    Protein Accession:
    Q9Y2C5
    Secondary Accessions:
    • B4DDV9
    • E7EPE8
    • E7EU17
    • Q32MB7
    • Q32MB8

    Protein attributes for SLC17A4 Gene

    Size:
    497 amino acids
    Molecular mass:
    54055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC17A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A4 Gene

Post-translational modifications for SLC17A4 Gene

  • Glycosylation at isoforms=347, isoforms=2, 3, 456, isoforms=2, 3, 466, isoforms=2, 3, 475, and isoforms=2, 3, 490
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC17A4 Gene

Domains & Families for SLC17A4 Gene

Gene Families for SLC17A4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC17A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC17A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2C5

UniProtKB/Swiss-Prot:

S17A4_HUMAN :
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
genes like me logo Genes that share domains with SLC17A4: view

Function for SLC17A4 Gene

Molecular function for SLC17A4 Gene

GENATLAS Biochemistry:
solute carrier family(sodium/phosphate cotransport),member 4
UniProtKB/Swiss-Prot Function:
Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).

Phenotypes From GWAS Catalog for SLC17A4 Gene

Gene Ontology (GO) - Molecular Function for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005436 sodium:phosphate symporter activity TAS 10319585
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC17A4: view
genes like me logo Genes that share phenotypes with SLC17A4: view

Animal Model Products

CRISPR Products

miRNA for SLC17A4 Gene

miRTarBase miRNAs that target SLC17A4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC17A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC17A4 Gene

Localization for SLC17A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A4 Gene

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Apical in the intestinal brush border.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC17A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10319585
GO:0016020 membrane TAS 10319585
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC17A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC17A4 Gene

Pathways & Interactions for SLC17A4 Gene

SuperPathways for SLC17A4 Gene

No Data Available

Interacting Proteins for SLC17A4 Gene

Gene Ontology (GO) - Biological Process for SLC17A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 10319585
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport TAS 10319585
GO:0035435 phosphate ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC17A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC17A4 Gene

Drugs & Compounds for SLC17A4 Gene

(1) Additional Compounds for SLC17A4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC17A4: view

Transcripts for SLC17A4 Gene

mRNA/cDNA for SLC17A4 Gene

Unigene Clusters for SLC17A4 Gene

Solute carrier family 17 (sodium phosphate), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC17A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: - -
SP3:

Relevant External Links for SLC17A4 Gene

GeneLoc Exon Structure for
SLC17A4
ECgene alternative splicing isoforms for
SLC17A4

Expression for SLC17A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC17A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC17A4 Gene

This gene is overexpressed in Liver (x18.2), Colon - Transverse (x12.3), Pancreas (x11.9), and Small Intestine - Terminal Ileum (x6.6).

NURSA nuclear receptor signaling pathways regulating expression of SLC17A4 Gene:

SLC17A4

SOURCE GeneReport for Unigene cluster for SLC17A4 Gene:

Hs.282931

mRNA Expression by UniProt/SwissProt for SLC17A4 Gene:

Q9Y2C5-S17A4_HUMAN
Tissue specificity: Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs.

Evidence on tissue expression from TISSUES for SLC17A4 Gene

  • Intestine(4.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SLC17A4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC17A4 Gene

Orthologs for SLC17A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A4 33 34
  • 99.53 (n)
mouse
(Mus musculus)
Mammalia Slc17a4 33 16 34
  • 82.52 (n)
rat
(Rattus norvegicus)
Mammalia Slc17a4 33
  • 82.49 (n)
dog
(Canis familiaris)
Mammalia SLC17A4 33 34
  • 80.8 (n)
cow
(Bos Taurus)
Mammalia SLC17A4 33 34
  • 80.76 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 34
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8791 35
  • 31 (a)
CG2003 35
  • 29 (a)
CG3649 35
  • 29 (a)
CG7881 35
  • 27 (a)
CG9825 35
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea F21F8.11 35
  • 26 (a)
T09B9.2 35
  • 25 (a)
ZK682.2 35
  • 25 (a)
Species where no ortholog for SLC17A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC17A4 Gene

ENSEMBL:
Gene Tree for SLC17A4 (if available)
TreeFam:
Gene Tree for SLC17A4 (if available)

Paralogs for SLC17A4 Gene

Paralogs for SLC17A4 Gene

(7) SIMAP similar genes for SLC17A4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC17A4: view

Variants for SLC17A4 Gene

Sequence variations from dbSNP and Humsavar for SLC17A4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000140139 -- 25,777,073(+) AATGT(C/T)AGCAC intron-variant, nc-transcript-variant, downstream-variant-500B
rs1000200195 -- 25,763,697(+) GTAAC(C/T)GTTCC intron-variant
rs1000213434 -- 25,756,870(+) TAGCT(C/T)GTGGA intron-variant
rs1000273680 -- 25,763,441(+) CTTTG(C/T)CAGTT intron-variant
rs1000748670 -- 25,758,245(+) TTGAA(A/G)TGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A4 Gene

Variant ID Type Subtype PubMed ID
nsv1117610 CNV deletion 24896259
nsv477888 CNV novel sequence insertion 20440878

Variation tolerance for SLC17A4 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC17A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC17A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A4 Gene

Disorders for SLC17A4 Gene

Relevant External Links for SLC17A4

Genetic Association Database (GAD)
SLC17A4
Human Genome Epidemiology (HuGE) Navigator
SLC17A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC17A4

No disorders were found for SLC17A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC17A4 Gene

Publications for SLC17A4 Gene

  1. Isolation and chromosomal mapping of a novel human gene showing homology to Na+/PO4 cotransporter. (PMID: 10319585) Shibui A … Sugano S (Journal of human genetics 1999) 2 3 4 60
  2. A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. (PMID: 22460716) Togawa N … Moriyama Y (American journal of physiology. Cell physiology 2012) 3 4 60
  3. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PMID: 21943158) Middelberg RP … Whitfield JB (BMC medical genetics 2011) 3 45 60
  4. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. (PMID: 21909108) Bis JC … CARDIoGRAM Consortium (Nature genetics 2011) 3 45 60
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for SLC17A4 Gene

Sources for SLC17A4 Gene

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