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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC17A4 Gene

protein-coding   GIFtS: 52
GCID: GC06P025754

Solute Carrier Family 17, Member 4

(Previous names: solute carrier family 17 (sodium phosphate), member 4)
  Search for SLC17A4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 17, Member 41 2
Solute Carrier Family 17 (Sodium Phosphate), Member 41 2
Solute Carrier Family 17 Member 42 3
KAIA21382
Na/PO4 Cotransporter2
Putative Small Intestine Sodium-Dependent Phosphate Transport Protein2

External Ids:    HGNC: 109321   Entrez Gene: 100502   Ensembl: ENSG000001460397   OMIM: 6042165   UniProtKB: Q9Y2C53   

Export aliases for SLC17A4 gene to outside databases

Previous GC identifers: GC06P025812 GC06P025862 GC06P025697


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC17A4 Gene:
Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption,
and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is
the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule.
NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell
membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important
role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 (PubMed
10319585)).(supplied by OMIM, Feb 2011)

GeneCards Summary for SLC17A4 Gene: 
SLC17A4 (solute carrier family 17, member 4) is a protein-coding gene. GO annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A7.

UniProtKB/Swiss-Prot: S17A4_HUMAN, Q9Y2C5
Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC17A4 gene promoter:
         AP-1   ATF-2   CUTL1   HNF-1A   Pax-3   POU2F1   POU2F1a   HNF-1   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC17A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC17A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.2   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.2

SLC17A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P025754:  view genomic region     (about GC identifiers)

Start:
25,754,927 bp from pter      End:
25,781,419 bp from pter
Size:
26,493 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S17A4_HUMAN, Q9Y2C5 (See protein sequence)
Recommended Name: Putative small intestine sodium-dependent phosphate transport protein  
Size: 497 amino acids; 54055 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q32MB7
Alternative splicing: 2 isoforms:  Q9Y2C5-1   Q9Y2C5-2   

Explore the universe of human proteins at neXtProt for SLC17A4: NX_Q9Y2C5

Explore proteomics data for SLC17A4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2C5

  • SLC17A4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC17A4 Protein Expression
    REFSEQ proteins: NP_005486.1  
    ENSEMBL proteins: 
     ENSP00000367137   ENSP00000391345   ENSP00000380266  

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    Cloud-Clone Corp. Proteins for SLC17A4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10319585
    GO:0016020membrane TAS10319585
    GO:0016021integral to membrane ----

    SLC17A4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/phosphate cotransporter homolog 
    Type I sodium-phosphate co-transporters

    3 InterPro protein domains:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9Y2C5

    ProtoNet protein and cluster: Q9Y2C5

    UniProtKB/Swiss-Prot: S17A4_HUMAN, Q9Y2C5
    Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family


    SLC17A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S17A4_HUMAN, Q9Y2C5
    Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport (By similarity)

         Genatlas biochemistry entry for SLC17A4:
    solute carrier family(sodium/phosphate cotransport),member 4

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005436sodium:phosphate symporter activity TAS10319585
         
    SLC17A4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC17A4:
     Wnt reporter downregulated 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC17A4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC17A4 (ENSP000003671374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZK1ENSP000003421434STRING: ENSP00000342143
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006796phosphate-containing compound metabolic process TAS10319585
    GO:0006814sodium ion transport TAS10319585
    GO:0055085transmembrane transport ----

    SLC17A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC17A4 (S17A4)

    1 HMDB Compound for SLC17A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about SLC17A4 / S17A4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC17A4 gene: 
    NM_005495.2  

    Unigene Cluster for SLC17A4:

    Solute carrier family 17 (sodium phosphate), member 4
    Hs.282931  [show with all ESTs]
    Unigene Representative Sequence: AK024903
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377905(uc003nfe.3 uc011djx.2 uc003nfg.3 uc010jqa.3)
    ENST00000439485 ENST00000397076(uc003nff.1)
    miRNA
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    hsa-miR-3140-3p hsa-miR-1976 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB020527.1 AK024903.1 AK293354.1 AK308500.1 BC109207.1 BC109208.1 Y10506.1 Y10512.1 

    6 DOTS entries:

    DT.97787499  DT.106451  DT.121393392  DT.40274237  DT.75136168  DT.40219196 

    14 AceView cDNA sequences:

    BX499419 AA977108 AA976968 AI056789 W86874 NM_005495 AK024903 BX109919 
    AW662505 AB020527 AI371973 AI240656 AU098577 R09123 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                                                  -                                             
    SP2:              -                                   -                                             
    SP3:                                                                                                


    ECgene alternative splicing isoforms for SLC17A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC17A4 expression in normal human tissues (normalized intensities)      SLC17A4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAAAGTG
    SLC17A4 Expression
    About this image


    SLC17A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Spinal Ventral Columns
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Kidney (Urinary System)
             Metanephros

    See SLC17A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC17A4

    SOURCE GeneReport for Unigene cluster: Hs.282931

    UniProtKB/Swiss-Prot: S17A4_HUMAN, Q9Y2C5
    Tissue specificity: Expressed intestine, colon, liver and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC17A4 gene from 2/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc17a41 , 5 solute carrier family 17 (sodium phosphate), member more1, 5 82.52(n)1
    79.07(a)1
      13 (9.98 cM)5
    3198481  NM_177016.31  NP_795990.21 
     238977385 
    zebrafish
    (Danio rerio)
    Actinopterygii CU929219.16
    Uncharacterized protein
    36(a)
    1 → many
    19(44811733-44829601)


    ENSEMBL Gene Tree for SLC17A4 (if available)
    TreeFam Gene Tree for SLC17A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC17A4 gene
    SLC17A72  SLC17A82  SLC17A62  SLC17A32  SLC17A12  SLC17A52  SLC17A92  SLC17A22  
    7 SIMAP similar genes for SLC17A4 using alignment to 4 protein entries:     S17A4_HUMAN (see all proteins):
    SLC17A1    SLC17A2    SLC17A3    SLC17A8    SLC17A5    SLC17A6
    SLC17A7

    SLC17A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/693 SNPs in SLC17A4 are shown (see all 693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507686941,2
    C--25753096(+) AATGGC/TGTGAA 1 -- us2k10--------
    rs2012964831,2
    C--25753196(+) AAAAA-/ACAAAAA 1 -- us2k10--------
    rs1127361031,2
    --25753207(+) AAAAAC/ACACCA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1494780031,2
    --25753344(+) ATATTA/GGAGGC 1 -- us2k10--------
    rs759957241,2
    C--25753450(+) GGAACT/CGCAAG 1 -- us2k12Minor allele frequency- C:0.08CSA WA 120
    rs43792841,2
    C,F,H--25753492(+) gaactG/Agttgg 1 -- us2k116Minor allele frequency- A:0.03NS EA NA WA CSA 793
    rs1847231671,2
    --25753546(+) GGTGTC/GTCCAA 1 -- us2k10--------
    rs789750851,2
    C,F--25753589(+) GGTGAA/GTTTGC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1883110521,2
    --25753595(+) TTTGCC/TCTCTT 1 -- us2k10--------
    rs122008381,2
    C,F--25753603(+) cttttC/Ttccta 1 -- us2k1 trp39Minor allele frequency- N:0.00EA NA WA 576

    HapMap Linkage Disequilibrium report for SLC17A4 (25754927 - 25781419 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC17A4: --

    Human Gene Mutation Database (HGMD): SLC17A4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC17A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC17A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC17A4 for disorders           About MalaCards
    OMIM gene information: 604216    OMIM disorders: --


    SLC17A4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC17A4
    Human Genome Epidemiology (HuGE) Navigator: SLC17A4 (1 document)

    Export disorders for SLC17A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC17A4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC17A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal mapping of a novel human gene showing homology to Na+/PO4 cotransporter. (PubMed id 10319585)1, 2, 3 Shibui A.... Sugano S. (1999)
    2. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C 4 genes are associated with multiple cardiovascular-related traits. (PubMed id 21943158)1, 4 Middelberg R.P....Whitfield J.B. (2011)
    3. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. (PubMed id 21909108)1, 4 Bis J.C....O'Donnell C.J. (2011)
    4. A Na+-phosphate cotransporter homologue (SLC17A4 prote in) is an intestinal organic anion exporter. (PubMed id 22460716)1 Togawa N....Moriyama Y. (2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Kinetic evidence that the Na-PO4 cotransporter is the molecular mechanism for Na/Li exchange in human red blood cells. (PubMed id 12672655)1 Elmariah S. and Gunn R.B. (2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10050 HGNC: 10932 AceView: SLC17A4 Ensembl:ENSG00000146039 euGenes: HUgn10050
    ECgene: SLC17A4 H-InvDB: SLC17A4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC17A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC17A4 gene:
    Search GeneIP for patents involving SLC17A4

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