Aliases for SLC17A4 Gene
External Ids for SLC17A4 Gene
Previous GeneCards Identifiers for SLC17A4 Gene
Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]
GeneCards Summary for SLC17A4 Gene
SLC17A4 (Solute Carrier Family 17, Member 4) is a Protein Coding gene. GO annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A8.
UniProtKB/Swiss-Prot for SLC17A4 Gene
Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).