Aliases for SLC17A3 Gene
External Ids for SLC17A3 Gene
Previous GeneCards Identifiers for SLC17A3 Gene
The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
GeneCards Summary for SLC17A3 Gene
SLC17A3 (Solute Carrier Family 17 Member 3) is a Protein Coding gene. Diseases associated with SLC17A3 include gout susceptibility 4 and gout. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Uricosurics Pathway, Pharmacodynamics. GO annotations related to this gene include organic anion transmembrane transporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC17A8.
UniProtKB/Swiss-Prot for SLC17A3 Gene
Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.