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SLC17A3 Gene

protein-coding   GIFtS: 59
GCID: GC06M025833

Solute Carrier Family 17 (Organic Anion Transporter), Member...

(Previous names: solute carrier family 17 (sodium phosphate), member 3)
  See SLC17A3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 17 (Organic Anion Transporter), Member 31 2     Na(+)/PI Cotransporter 42 3
NPT42 3 5     Sodium-Dependent Phosphate Transport Protein 42
Solute Carrier Family 17 (Sodium Phosphate), Member 31 2     Solute Carrier Family 17 Member 33
Sodium/Phosphate Cotransporter 42 3     

External Ids:    HGNC: 109311   Entrez Gene: 107862   Ensembl: ENSG000001245647   OMIM: 6110345   UniProtKB: O004763   

Export aliases for SLC17A3 gene to outside databases

Previous GC identifers: GC06M025902 GC06M025953 GC06M025788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC17A3 Gene:
The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic
anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been
found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter
isoform localizes to the endoplasmic reticulum. (provided by RefSeq, Aug 2012)

GeneCards Summary for SLC17A3 Gene:
SLC17A3 (solute carrier family 17 (organic anion transporter), member 3) is a protein-coding gene. Diseases associated with SLC17A3 include gout susceptibility 4, and gout. GO annotations related to this gene include organic anion transmembrane transporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC17A7.

UniProtKB/Swiss-Prot: NPT4_HUMAN, O00476
Function: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport
para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform
2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an
exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate
into cells via Na(+) cotransport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC17A3 gene promoter:
         Nkx3-1 v4   AML1a   Lmo2   Nkx3-1 v1   POU6F1 (c2)   HNF-1A   Nkx3-1 v2   HNF-1   Nkx3-1 v3   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC17A3 promoter sequence
   Search Chromatin IP Primers for SLC17A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC17A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.2

SLC17A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC17A3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M025833:  view genomic region     (about GC identifiers)

Start:
25,833,294 bp from pter      End:
25,882,514 bp from pter
Size:
49,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPT4_HUMAN, O00476 (See protein sequence)
Recommended Name: Sodium-dependent phosphate transport protein 4  
Size: 420 amino acids; 46106 Da
Sequence caution: Sequence=AAB53423.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B7WNJ5 B7Z511 Q8WWC7 Q9H533
Alternative splicing: 2 isoforms:  O00476-1   O00476-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC17A3: NX_O00476

Explore proteomics data for SLC17A3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn60, Asn68, Asn77
  • Modification sites at PhosphoSitePlus

  • See SLC17A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091956.1  NP_006623.2  

    ENSEMBL proteins: 
     ENSP00000421855   ENSP00000424027   ENSP00000380250   ENSP00000355307   ENSP00000353873  
     ENSP00000424729   ENSP00000415622  
    Reactome Protein details: O00476

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/phosphate cotransporter 4
    Type I sodium-phosphate co-transporters

    4 InterPro protein domains:
     IPR011701 MFS
     IPR017373 Na-dep_P-transpt_4_prd
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O00476

    ProtoNet protein and cluster: O00476

    UniProtKB/Swiss-Prot: NPT4_HUMAN, O00476
    Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family


    Find genes that share domains with SLC17A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPT4_HUMAN, O00476
    Function: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport
    para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform
    2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an
    exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate
    into cells via Na(+) cotransport

         Genatlas biochemistry entry for SLC17A3:
    solute carrier family 17 (sodium/phosphate cotransport) member 3,expressed in liver and kidney

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005436sodium:phosphate symporter activity ISS--
    GO:0008308voltage-gated anion channel activity IDA--
    GO:0008514organic anion transmembrane transporter activity IDA--
    GO:0015143urate transmembrane transporter activity IDA--
    GO:0015238drug transmembrane transporter activity IDA--
         
    Find genes that share ontologies with SLC17A3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC17A3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC17A3
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    miRNA
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    miRTarBase miRNAs that target SLC17A3:
    hsa-mir-335-5p (MIRT017850)

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    1 qRT-PCR Assays for microRNA that regulate SLC17A3:
    hsa-miR-587
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPT4_HUMAN, O00476: Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein
    NPT4_HUMAN, O00476: Isoform 2: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC17A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC17A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with SLC17A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC17A3
        Stimuli-sensing channels


        Pathway & Disease-focused RT2 Profiler PCR Array including SLC17A3: 
              Hepatotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC17A3

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport ISS--
    GO:0006817phosphate ion transport ISS--
    GO:0006855drug transmembrane transport IDA--
    GO:0015711organic anion transport IDA--
    GO:0015747urate transport IDA--

    Find genes that share ontologies with SLC17A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC17A3 (NPT4)

    1 HMDB Compound for SLC17A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC17A3 gene (2 alternative transcripts): 
    NM_001098486.1  NM_006632.3  

    Unigene Cluster for SLC17A3:

    Solute carrier family 17 (sodium phosphate), member 3
    Hs.327179  [show with all ESTs]
    Unigene Representative Sequence: AK298271
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481949 ENST00000505420 ENST00000397060(uc003nfk.4 uc003nfi.4)
    ENST00000361703 ENST00000360657 ENST00000509714(uc011djz.1) ENST00000506105
    ENST00000503922(uc011dka.1) ENST00000308453 ENST00000449356
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SLC17A3:
    hsa-miR-587
    SwitchGear 3'UTR luciferase reporter plasmidSLC17A3 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC17A3

    Additional mRNA sequence: 

    AK296082.1 AK298271.1 AK298367.1 BC017952.1 U90545.1 Z83953.1 

    5 DOTS entries:

    DT.403125  DT.100742561  DT.121332300  DT.40120631  DT.95204537 

    19 AceView cDNA sequences:

    AI222455 CB163247 AI733707 BX107915 BC017952 U90545 AI244777 NM_006632 
    BG427288 AA858296 BF431676 AI821963 AI311320 AI792430 Z83953 AA706766 
    AI247271 AA814153 BG399960 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                    -                 -                                   -                                             
    SP2:        -     -     -                 -                                   -                                             
    SP3:                    -                 -     -                                                                           
    SP4:                    -                                                                                                   
    SP5:                                      -     -                                                                           


    ECgene alternative splicing isoforms for SLC17A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC17A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGAGGCT
    SLC17A3 Expression
    About this image


    SLC17A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Glomerulus
     
     Liver (Hepatobiliary System)
    SLC17A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC17A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.327179

    UniProtKB/Swiss-Prot: NPT4_HUMAN, O00476
    Tissue specificity: Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well
    as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC17A3: 
              Hepatotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC17A3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc17a31 , 5 solute carrier family 17 (sodium phosphate), member more1, 5 73.63(n)1
    64.86(a)1
      13 (9.95 cM)5
    1053551  NM_134069.31  NP_598830.21 
     238394495 
    zebrafish
    (Danio rerio)
    Actinopterygii CU929219.16
    Uncharacterized protein
    32(a)
    1 → many
    19(44811733-44829601) ENSDARG00000086739


    ENSEMBL Gene Tree for SLC17A3 (if available)
    TreeFam Gene Tree for SLC17A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC17A3 gene
    SLC17A72  SLC17A82  SLC17A62  SLC17A42  SLC17A12  SLC17A52  SLC17A92  SLC17A22  
    5 SIMAP similar genes for SLC17A3 using alignment to 4 protein entries:     NPT4_HUMAN (see all proteins):
    SLC17A1    SLC17A4    SLC17A5    SLC17A2    SLC17A7

    Find genes that share paralogs with SLC17A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    NPT4_HUMAN, O00476: Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define
    the serum uric acid concentration quantitative trait locus 4 (UAQTL4) [MIM:612671]. Excess serum accumulation of
    uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium
    urate crystals as a consequence of hyperuricemia


    Selected SNPs for SLC17A3 (see all 643)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782591491,2
    F--25767060(+) AGAACC/TGAACA 2 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1397529361,2
    --25767094(+) AAAAGG/TCTGAA 2 -- ds50010--------
    rs1848827671,2
    --25767145(+) GCTGCC/TTTCCA 2 -- ds50010--------
    rs560107471,2
    C,F--25767198(+) AAAGAC/GAGACT 2 -- ds50012Minor allele frequency- G:0.33WA CSA 3
    rs766302541,2
    C,F--25767219(+) AACACC/AGCCTG 2 -- ds50011Minor allele frequency- A:0.03EA 120
    rs287001691,2
    C--25767269(+) GGACAA/GGGGAG 2 -- ds50011Minor allele frequency- G:0.00NA 2
    rs623942881,2
    C--25767295(+) ATATGG/AGTCAG 2 -- ds50014Minor allele frequency- A:0.07NA CSA EA 243
    rs1478675811,2
    --25767338(+) GGAGGA/GCATAT 2 -- ds50010--------
    rs1897915821,2
    --25767441(+) CACCCC/TGGATT 2 -- ds50010--------
    rs1414458001,2
    C--25767496(+) ACATAC/TTGGGT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC17A3 (25833294 - 25882514 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC17A3: --
    Human Gene Mutation Database (HGMD): SLC17A3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC17A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC17A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611034   
    OMIM disorders: 612671  
    2 diseases for SLC17A3:    
    About MalaCards
    gout susceptibility 4    gout

    2 diseases from the University of Copenhagen DISEASES database for SLC17A3:
    Gout     Hyperuricemia

    Find genes that share disorders with SLC17A3           About GenesLikeMe

    Genetic Association Database (GAD): SLC17A3
    Human Genome Epidemiology (HuGE) Navigator: SLC17A3 (7 documents)

    Export disorders for SLC17A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC17A3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SLC17A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PubMed id 9149941)1, 2, 3 Ruddy D.A.... Feder J.N. (Genome Res. 1997)
    2. NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic. (PubMed id 15505377)1, 2, 9 Melis D.... Verheijen F. (J. Inherit. Metab. Dis. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. (PubMed id 20810651)1, 2 Jutabha P.... Sakurai H. (J. Biol. Chem. 2010)
    5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    6. Sex and age interaction with genetic association of atherogenic uric acid concentrations. (PubMed id 20053405)1, 4 BrandstAotter A....Kronenberg F. (Atherosclerosis 2010)
    7. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PubMed id 19890391)1, 4 Stark K....Hengstenberg C. (PLoS ONE 2009)
    8. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    9. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PubMed id 19571809)1, 4 Shi J....Gejman P.V. (Nature 2009)
    10. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. (PubMed id 18834626)1, 4 Dehghan A.... Fox C.S. (Lancet 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10786 HGNC: 10931 AceView: SLC17A3 Ensembl:ENSG00000124564 euGenes: HUgn10786
    ECgene: SLC17A3 H-InvDB: SLC17A3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC17A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC17A3 gene:
    Search GeneIP for patents involving SLC17A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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