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Aliases for SLC17A3 Gene

Aliases for SLC17A3 Gene

  • Solute Carrier Family 17 (Organic Anion Transporter), Member 3 2 3
  • NPT4 3 4 6
  • Solute Carrier Family 17 (Sodium Phosphate), Member 3 2 3
  • Sodium/Phosphate Cotransporter 4 3 4
  • Na(+)/PI Cotransporter 4 3 4
  • Sodium-Dependent Phosphate Transport Protein 4 3
  • Solute Carrier Family 17 Member 3 4

External Ids for SLC17A3 Gene

Summaries for SLC17A3 Gene

Entrez Gene Summary for SLC17A3 Gene

  • The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]

GeneCards Summary for SLC17A3 Gene

SLC17A3 (Solute Carrier Family 17 (Organic Anion Transporter), Member 3) is a Protein Coding gene. Diseases associated with SLC17A3 include gout susceptibility 4 and gout. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include organic anion transmembrane transporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A3 Gene

  • Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A3 Gene

Genomics for SLC17A3 Gene

Genomic Location for SLC17A3 Gene

Start:
25,833,066 bp from pter
End:
25,882,286 bp from pter
Size:
49,221 bases
Orientation:
Minus strand

Genomic View for SLC17A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC17A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A3 Gene

Regulatory Elements for SLC17A3 Gene

Proteins for SLC17A3 Gene

  • Protein details for SLC17A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00476-NPT4_HUMAN
    Recommended name:
    Sodium-dependent phosphate transport protein 4
    Protein Accession:
    O00476
    Secondary Accessions:
    • B7WNJ5
    • B7Z511
    • Q8WWC7
    • Q9H533

    Protein attributes for SLC17A3 Gene

    Size:
    420 amino acids
    Molecular mass:
    46106 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB53423.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC17A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A3 Gene

Proteomics data for SLC17A3 Gene at MOPED

Post-translational modifications for SLC17A3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn49, Asn60, Asn68, and Asn77

Other Protein References for SLC17A3 Gene

No data available for DME Specific Peptides for SLC17A3 Gene

Domains for SLC17A3 Gene

Gene Families for SLC17A3 Gene

Protein Domains for SLC17A3 Gene

UniProtKB/Swiss-Prot:

NPT4_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.:
    • O00476
genes like me logo Genes that share domains with SLC17A3: view

Function for SLC17A3 Gene

Molecular function for SLC17A3 Gene

GENATLAS Biochemistry: solute carrier family 17 (sodium/phosphate cotransport) member 3,expressed in liver and kidney
UniProtKB/Swiss-Prot Function: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport

Gene Ontology (GO) - Molecular Function for SLC17A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005436 sodium:phosphate symporter activity ISS --
GO:0008308 voltage-gated anion channel activity IDA 20810651
GO:0008514 organic anion transmembrane transporter activity IDA 20810651
GO:0015143 urate transmembrane transporter activity IDA 20810651
GO:0015238 drug transmembrane transporter activity IDA 20810651
genes like me logo Genes that share ontologies with SLC17A3: view

Phenotypes for SLC17A3 Gene

GenomeRNAi human phenotypes for SLC17A3:
genes like me logo Genes that share phenotypes with SLC17A3: view

miRNA for SLC17A3 Gene

miRTarBase miRNAs that target SLC17A3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC17A3 Gene

Localization for SLC17A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A3 Gene

Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A3 Gene COMPARTMENTS Subcellular localization image for SLC17A3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC17A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20810651
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 20810651
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC17A3: view

Pathways for SLC17A3 Gene

genes like me logo Genes that share pathways with SLC17A3: view

Pathways by source for SLC17A3 Gene

Interacting Proteins for SLC17A3 Gene

Gene Ontology (GO) - Biological Process for SLC17A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport ISS --
GO:0006817 phosphate ion transport ISS --
GO:0006855 drug transmembrane transport IDA 20810651
GO:0015711 organic anion transport IDA 20810651
GO:0015747 urate transport IDA 20810651
genes like me logo Genes that share ontologies with SLC17A3: view

Compounds for SLC17A3 Gene

(1) HMDB Compounds for SLC17A3 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC17A3: view

Transcripts for SLC17A3 Gene

mRNA/cDNA for SLC17A3 Gene

Unigene Clusters for SLC17A3 Gene

Solute carrier family 17 (sodium phosphate), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for SLC17A3 Gene

GeneLoc Exon Structure for
SLC17A3
ECgene alternative splicing isoforms for
SLC17A3

Expression for SLC17A3 Gene

mRNA expression in normal human tissues for SLC17A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC17A3 Gene

This gene is overexpressed in Kidney - Cortex (37.4) and Liver (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC17A3 Gene

SOURCE GeneReport for Unigene cluster for SLC17A3 Gene Hs.327179

mRNA Expression by UniProt/SwissProt for SLC17A3 Gene

O00476-NPT4_HUMAN
Tissue specificity: Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).
genes like me logo Genes that share expressions with SLC17A3: view

Orthologs for SLC17A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC17A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A3 36
  • 99.33 (n)
  • 98.8 (a)
SLC17A3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A3 36
  • 80.28 (n)
  • 70.93 (a)
SLC17A3 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 49 (a)
OneToMany
LOC478741 36
  • 81.32 (n)
  • 71.37 (a)
mouse
(Mus musculus)
Mammalia Slc17a3 36
  • 73.63 (n)
  • 64.86 (a)
Slc17a3 16
Slc17a3 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 40 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc17a3 36
  • 74.16 (n)
  • 64.86 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 37
  • 32 (a)
OneToMany
Species with no ortholog for SLC17A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC17A3 Gene

ENSEMBL:
Gene Tree for SLC17A3 (if available)
TreeFam:
Gene Tree for SLC17A3 (if available)

Paralogs for SLC17A3 Gene

Paralogs for SLC17A3 Gene

Selected SIMAP similar genes for SLC17A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC17A3: view

Variants for SLC17A3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A3 Gene

O00476-NPT4_HUMAN
Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 4 (UAQTL4) [MIM:612671]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia

Sequence variations from dbSNP and Humsavar for SLC17A3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs501220 -- 25,872,797(-) GACCT(G/T)TCTGT intron-variant
rs523383 -- 25,869,620(-) tgctc(C/T)ttctt intron-variant
rs548987 -- 25,869,143(-) GGTCA(C/G)AACCT intron-variant
rs555460 -- 25,870,427(+) TGCTC(C/T)TTTAT intron-variant
rs556339 -- 25,870,517(-) ACCTG(A/G)CATTT intron-variant

Relevant External Links for SLC17A3 Gene

HapMap Linkage Disequilibrium report
SLC17A3
Human Gene Mutation Database (HGMD)
SLC17A3

No data available for Structural Variations from Database of Genomic Variants (DGV) for SLC17A3 Gene

Disorders for SLC17A3 Gene

(1) OMIM Diseases for SLC17A3 Gene (611034)

(2) MalaCards Diseases for SLC17A3 Gene

Search for SLC17A3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SLC17A3 Gene

Relevant External Links for SLC17A3

Genetic Association Database (GAD)
SLC17A3
Human Genome Epidemiology (HuGE) Navigator
SLC17A3
genes like me logo Genes that share disorders with SLC17A3: view

No data available for UniProtKB/Swiss-Prot for SLC17A3 Gene

Publications for SLC17A3 Gene

  1. NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic. (PMID: 15505377) Melis D. … Verheijen F. (J. Inherit. Metab. Dis. 2004) 3 4 23
  2. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4
  3. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. (PMID: 18834626) Dehghan A. … Fox C.S. (Lancet 2008) 3 49
  4. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J. … Gejman P.V. (Nature 2009) 3 49
  5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3 49

Products for SLC17A3 Gene

Sources for SLC17A3 Gene

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