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Aliases for SLC17A2 Gene

Aliases for SLC17A2 Gene

  • Solute Carrier Family 17, Member 2 2 3
  • NPT3 3 4 6
  • Sodium/Phosphate Cotransporter 3 3 4
  • Na(+)/PI Cotransporter 3 3 4
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 2 3
  • Solute Carrier Family 17 (Sodium Phosphate), Member 2 2
  • Sodium-Dependent Phosphate Transport Protein 3 3
  • Solute Carrier Family 17 Member 2 4
  • Sodium Phosphate Transporter 3 3

External Ids for SLC17A2 Gene

Summaries for SLC17A2 Gene

GeneCards Summary for SLC17A2 Gene

SLC17A2 (Solute Carrier Family 17, Member 2) is a Protein Coding gene. Diseases associated with SLC17A2 include fanconi renotubular syndrome 2 and nephrolithiasis/osteoporosis, hypophosphatemic, 1. Among its related pathways are Osteoblast Signaling. GO annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A2 Gene

  • May be involved in actively transporting phosphate into cells via Na(+) cotransport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A2 Gene

Genomics for SLC17A2 Gene

Genomic Location for SLC17A2 Gene

Start:
25,912,754 bp from pter
End:
25,930,726 bp from pter
Size:
17,973 bases
Orientation:
Minus strand

Genomic View for SLC17A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC17A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A2 Gene

Regulatory Elements for SLC17A2 Gene

Proteins for SLC17A2 Gene

  • Protein details for SLC17A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00624-NPT3_HUMAN
    Recommended name:
    Sodium-dependent phosphate transport protein 3
    Protein Accession:
    O00624
    Secondary Accessions:
    • A6NK81
    • A6NLD6
    • Q5TB84
    • Q76P85

    Protein attributes for SLC17A2 Gene

    Size:
    439 amino acids
    Molecular mass:
    47277 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC17A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A2 Gene

Proteomics data for SLC17A2 Gene at MOPED

Post-translational modifications for SLC17A2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn47, Asn56, Asn68, and Asn69

Other Protein References for SLC17A2 Gene

No data available for DME Specific Peptides for SLC17A2 Gene

Domains for SLC17A2 Gene

Gene Families for SLC17A2 Gene

Protein Domains for SLC17A2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NPT3_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.:
    • O00624
genes like me logo Genes that share domains with SLC17A2: view

Function for SLC17A2 Gene

Molecular function for SLC17A2 Gene

GENATLAS Biochemistry: solute carrier family 17 (sodium/phosphate cotransport) member 2,predominantly expressed in muscle and heart
UniProtKB/Swiss-Prot Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport.

Gene Ontology (GO) - Molecular Function for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005436 sodium:phosphate symporter activity TAS 9149941
genes like me logo Genes that share ontologies with SLC17A2: view

Phenotypes for SLC17A2 Gene

GenomeRNAi human phenotypes for SLC17A2:
genes like me logo Genes that share phenotypes with SLC17A2: view

miRNA for SLC17A2 Gene

miRTarBase miRNAs that target SLC17A2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC17A2 Gene

Localization for SLC17A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A2 Gene COMPARTMENTS Subcellular localization image for SLC17A2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9149941
GO:0016020 membrane TAS 9149941
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC17A2: view

Pathways for SLC17A2 Gene

SuperPathways for SLC17A2 Gene

Superpath Contained pathways
1 Osteoblast Signaling
genes like me logo Genes that share pathways with SLC17A2: view

Pathways by source for SLC17A2 Gene

1 BioSystems pathway for SLC17A2 Gene

Interacting Proteins for SLC17A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353677%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000363988%0d%0a
Selected Interacting proteins: ENSP00000353677 O00624-NPT3_HUMAN for SLC17A2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 9149941
GO:0006814 sodium ion transport TAS 9149941
GO:0035435 phosphate ion transmembrane transport TAS 9149941
GO:0035725 sodium ion transmembrane transport TAS 9149941
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC17A2: view

Compounds for SLC17A2 Gene

(1) HMDB Compounds for SLC17A2 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC17A2: view

Transcripts for SLC17A2 Gene

mRNA/cDNA for SLC17A2 Gene

Unigene Clusters for SLC17A2 Gene

Solute carrier family 17 (sodium phosphate), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2:
SP3: - -
SP4:
SP5: -

Relevant External Links for SLC17A2 Gene

GeneLoc Exon Structure for
SLC17A2
ECgene alternative splicing isoforms for
SLC17A2

Expression for SLC17A2 Gene

mRNA expression in normal human tissues for SLC17A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A2 Gene

This gene is overexpressed in Liver (52.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC17A2 Gene

SOURCE GeneReport for Unigene cluster for SLC17A2 Gene Hs.591802

mRNA Expression by UniProt/SwissProt for SLC17A2 Gene

O00624-NPT3_HUMAN
Tissue specificity: Expressed in the small intestine, kidney, spleen and testis. Not detected in fetal brain, bone marrow, and mammary gland.
genes like me logo Genes that share expressions with SLC17A2: view

Orthologs for SLC17A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC17A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A2 36
  • 98.98 (n)
  • 98.33 (a)
SLC17A2 37
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A2 36
  • 89.96 (n)
  • 89.96 (a)
SLC17A2 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC488255 36
  • 90.17 (n)
  • 88.49 (a)
SLC17A2 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a2 36
  • 85.94 (n)
  • 88.02 (a)
Slc17a2 16
Slc17a2 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 35 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 38 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc17a2 36
  • 85.64 (n)
  • 86.18 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 37
  • 29 (a)
OneToMany
Species with no ortholog for SLC17A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC17A2 Gene

ENSEMBL:
Gene Tree for SLC17A2 (if available)
TreeFam:
Gene Tree for SLC17A2 (if available)

Paralogs for SLC17A2 Gene

Paralogs for SLC17A2 Gene

Selected SIMAP similar genes for SLC17A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC17A2: view

Variants for SLC17A2 Gene

Sequence variations from dbSNP and Humsavar for SLC17A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs199740 -- 25,931,567(+) ttaca(A/G)ttcta upstream-variant-2KB
rs199741 -- 25,931,349(+) ATGAA(A/G)TGAGA upstream-variant-2KB
rs199742 -- 25,925,683(+) CGAAG(A/G)GTCAG intron-variant
rs199743 -- 25,925,367(+) attca(G/T)ctggg intron-variant
rs199744 -- 25,922,961(+) gaggc(C/T)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A2 Gene

Variant ID Type Subtype PubMed ID
nsv5229 CNV Loss 18451855

Relevant External Links for SLC17A2 Gene

HapMap Linkage Disequilibrium report
SLC17A2

Disorders for SLC17A2 Gene

Relevant External Links for SLC17A2

Genetic Association Database (GAD)
SLC17A2
Human Genome Epidemiology (HuGE) Navigator
SLC17A2
genes like me logo Genes that share disorders with SLC17A2: view

No data available for UniProtKB/Swiss-Prot for SLC17A2 Gene

Publications for SLC17A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PMID: 19890391) Stark K. … Hengstenberg C. (PLoS ONE 2009) 3 49
  4. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLC17A2 Gene

  • antibodies-online peptides for SLC17A2
  • antibodies-online antibodies for SLC17A2
  • antibodies-online kits for SLC17A2

Sources for SLC17A2 Gene

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