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Aliases for SLC17A2 Gene

Aliases for SLC17A2 Gene

  • Solute Carrier Family 17 Member 2 2 3 4
  • Solute Carrier Family 17, Member 2 2 5
  • Sodium/Phosphate Cotransporter 3 3 4
  • Na(+)/PI Cotransporter 3 3 4
  • NPT3 3 4
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 2 3
  • Solute Carrier Family 17 (Sodium Phosphate), Member 2 2
  • Sodium Phosphate Transporter 3 3

External Ids for SLC17A2 Gene

Previous GeneCards Identifiers for SLC17A2 Gene

  • GC06M025970
  • GC06M026020
  • GC06M025856

Summaries for SLC17A2 Gene

GeneCards Summary for SLC17A2 Gene

SLC17A2 (Solute Carrier Family 17 Member 2) is a Protein Coding gene. Diseases associated with SLC17A2 include nephrolithiasis/osteoporosis, hypophosphatemic, 1 and fanconi renotubular syndrome 2. Among its related pathways are Osteoblast Signaling. GO annotations related to this gene include sodium:phosphate symporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A2 Gene

  • May be involved in actively transporting phosphate into cells via Na(+) cotransport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A2 Gene

Genomics for SLC17A2 Gene

Regulatory Elements for SLC17A2 Gene

Genomic Location for SLC17A2 Gene

Chromosome:
6
Start:
25,912,754 bp from pter
End:
25,930,726 bp from pter
Size:
17,973 bases
Orientation:
Minus strand

Genomic View for SLC17A2 Gene

Genes around SLC17A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC17A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC17A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A2 Gene

Proteins for SLC17A2 Gene

  • Protein details for SLC17A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00624-NPT3_HUMAN
    Recommended name:
    Sodium-dependent phosphate transport protein 3
    Protein Accession:
    O00624
    Secondary Accessions:
    • A6NK81
    • A6NLD6
    • Q5TB84
    • Q76P85

    Protein attributes for SLC17A2 Gene

    Size:
    439 amino acids
    Molecular mass:
    47277 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC17A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A2 Gene

Proteomics data for SLC17A2 Gene at MOPED

Post-translational modifications for SLC17A2 Gene

  • Glycosylation at Asn 47, Asn 56, Asn 68, and Asn 69
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC17A2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC17A2

No data available for DME Specific Peptides for SLC17A2 Gene

Domains & Families for SLC17A2 Gene

Gene Families for SLC17A2 Gene

Protein Domains for SLC17A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC17A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00624

UniProtKB/Swiss-Prot:

NPT3_HUMAN :
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
genes like me logo Genes that share domains with SLC17A2: view

Function for SLC17A2 Gene

Molecular function for SLC17A2 Gene

GENATLAS Biochemistry:
solute carrier family 17 (sodium/phosphate cotransport) member 2,predominantly expressed in muscle and heart
UniProtKB/Swiss-Prot Function:
May be involved in actively transporting phosphate into cells via Na(+) cotransport.
genes like me logo Genes that share phenotypes with SLC17A2: view

Animal Model Products

CRISPR Products

miRNA for SLC17A2 Gene

miRTarBase miRNAs that target SLC17A2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC17A2 Gene

Localization for SLC17A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A2 Gene COMPARTMENTS Subcellular localization image for SLC17A2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9149941
genes like me logo Genes that share ontologies with SLC17A2: view

Pathways & Interactions for SLC17A2 Gene

SuperPathways for SLC17A2 Gene

Superpath Contained pathways
1 Osteoblast Signaling
genes like me logo Genes that share pathways with SLC17A2: view

Pathways by source for SLC17A2 Gene

1 BioSystems pathway for SLC17A2 Gene

Interacting Proteins for SLC17A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353677%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000363988%0d%0a
Selected Interacting proteins: ENSP00000353677 O00624-NPT3_HUMAN for SLC17A2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC17A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 9149941
GO:0035435 phosphate ion transmembrane transport TAS 9149941
GO:0035725 sodium ion transmembrane transport TAS 9149941
genes like me logo Genes that share ontologies with SLC17A2: view

No data available for SIGNOR curated interactions for SLC17A2 Gene

Drugs & Compounds for SLC17A2 Gene

(1) Additional Compounds for SLC17A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC17A2: view

Transcripts for SLC17A2 Gene

mRNA/cDNA for SLC17A2 Gene

Unigene Clusters for SLC17A2 Gene

Solute carrier family 17 (sodium phosphate), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2:
SP3: - -
SP4:
SP5: -

Relevant External Links for SLC17A2 Gene

GeneLoc Exon Structure for
SLC17A2
ECgene alternative splicing isoforms for
SLC17A2

Expression for SLC17A2 Gene

mRNA expression in normal human tissues for SLC17A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC17A2 Gene

This gene is overexpressed in Liver (x52.3).

Protein differential expression in normal tissues from HIPED for SLC17A2 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC17A2 Gene



SOURCE GeneReport for Unigene cluster for SLC17A2 Gene Hs.591802

mRNA Expression by UniProt/SwissProt for SLC17A2 Gene

O00624-NPT3_HUMAN
Tissue specificity: Expressed in the small intestine, kidney, spleen and testis. Not detected in fetal brain, bone marrow, and mammary gland.
genes like me logo Genes that share expression patterns with SLC17A2: view

Protein tissue co-expression partners for SLC17A2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC17A2 Gene

Orthologs for SLC17A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC17A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A2 35
  • 98.98 (n)
  • 98.33 (a)
SLC17A2 36
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A2 36
  • 70 (a)
OneToOne
SLC17A2 35
  • 89.96 (n)
  • 89.96 (a)
dog
(Canis familiaris)
Mammalia LOC488255 35
  • 90.17 (n)
  • 88.49 (a)
SLC17A2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a2 16
Slc17a2 36
  • 73 (a)
OneToOne
Slc17a2 35
  • 85.94 (n)
  • 88.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc17a2 35
  • 85.64 (n)
  • 86.18 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 36
  • 29 (a)
OneToMany
Species with no ortholog for SLC17A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC17A2 Gene

ENSEMBL:
Gene Tree for SLC17A2 (if available)
TreeFam:
Gene Tree for SLC17A2 (if available)

Paralogs for SLC17A2 Gene

Paralogs for SLC17A2 Gene

(7) SIMAP similar genes for SLC17A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC17A2: view

Variants for SLC17A2 Gene

Sequence variations from dbSNP and Humsavar for SLC17A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1540273 -- 25,923,930(-) TCACT(A/G)CATAC intron-variant
rs1853591 -- 25,915,177(-) TACCA(C/T)ATATA intron-variant
rs2575172 -- 25,919,638(+) gagct(C/T)gcagt intron-variant
rs3752421 -- 25,918,460(-) CCTAA(C/T)GCCTC intron-variant
rs3799372 -- 25,922,083(+) ATGCA(A/G)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A2 Gene

Variant ID Type Subtype PubMed ID
nsv5229 CNV Loss 18451855

Variation tolerance for SLC17A2 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC17A2 Gene

HapMap Linkage Disequilibrium report
SLC17A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A2 Gene

Disorders for SLC17A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC17A2 Gene - From: OMIM

Disorder Aliases PubMed IDs
nephrolithiasis/osteoporosis, hypophosphatemic, 1
  • hypophosphatemic nephrolithiasis/osteoporosis 1
fanconi renotubular syndrome 2
  • frts2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC17A2

Genetic Association Database (GAD)
SLC17A2
Human Genome Epidemiology (HuGE) Navigator
SLC17A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC17A2
genes like me logo Genes that share disorders with SLC17A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC17A2 Gene

Publications for SLC17A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy D.A. … Feder J.N. (Genome Res. 1997) 2 3 4 67
  2. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  3. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3
  4. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PMID: 19890391) Stark K. … Hengstenberg C. (PLoS ONE 2009) 3
  5. [Role of the type 3 sodium-dependent phosphate transporter in the calcification of growth plate chondrocytes]. (PMID: 17012827) Sugita A. … Yoneda T. (Clin Calcium 2006) 23

Products for SLC17A2 Gene

Sources for SLC17A2 Gene

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