SLC17A2 Gene
protein-coding GIFtS: 52
GCID: GC06M025912
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|
solute carrier family 17 (sodium phosphate), member 2
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Aliases
for SLC17A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 17 (Sodium Phosphate), Member 21 2 | | Na(+)/PI Cotransporter 32 3 | | NPT31 2 3 5 | | Sodium Phosphate Transporter 32 | | Sodium/Phosphate Cotransporter 32 3 | | Sodium-Dependent Phosphate Transport Protein 32 | | Solute Carrier Family 17 Member 22 3 | | Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 22 |
Export aliases for SLC17A2 gene to outside databasesPrevious GC identifers: GC06M025970 GC06M026020 GC06M025856 |
Summaries
for SLC17A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NPT3_HUMAN, O00624Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport (By similarity)
|
Genomic Views
for SLC17A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC17A2 gene promoter:
Pbx1a MEF-2 C/EBPalpha MEF-2A POU2F1 POU2F1a IRF-7A aMEF-2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC17A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.2SLC17A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M025912: view genomic region
(about GC identifiers)
Start:
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25,912,982 bp from pter |
End:
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25,930,946 bp from pter |
Size:
|
17,965 bases |
Orientation:
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minus strand |
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Proteins
for SLC17A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPT3_HUMAN, O00624 (See
protein sequence)Recommended Name: Sodium-dependent phosphate transport protein 3 Size: 439 amino acids; 47277 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A6NLD6 Q5TB84 Q76P85Alternative splicing: 2 isoforms: O00624-1 O00624-2 Explore the universe of human proteins at neXtProt for SLC17A2: NX_O00624
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00624
SLC17A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005826.1
ENSEMBL proteins: ENSP00000353677 ENSP00000265425 ENSP00000367081
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SLC17A2 for ontologies About GeneDecksing
SLC17A2 Antibody Products:
Assay Products for SLC17A2: |
Protein
Domains /
Families
for SLC17A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC17A2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00624ProtoNet protein and cluster: O00624 UniProtKB/Swiss-Prot: NPT3_HUMAN, O00624Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family |
Function
for SLC17A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NPT3_HUMAN, O00624Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport (By similarity) Genatlas biochemistry entry for SLC17A2:solute carrier family 17 (sodium/phosphate cotransport) member 2,predominantly expressed in muscle and heart
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC17A2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC17A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005436 | sodium:phosphate symporter activity |
TAS | 9149941 |
SLC17A2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC17A2:
|
Pathways & Interactions
for SLC17A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Osteoblast Signaling | |
1  BioSystems Pathway for SLC17A2
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC17A2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLC17A2 (O006243 ENSP000003536774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SLC17A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC17A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC17A2
1 HMDB Compound for SLC17A2 About this table
Search CenterWatch for drugs/clinical trials and news about SLC17A2 / NPT3
|
Transcripts
for SLC17A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC17A2 gene: NM_005835.2 Unigene Cluster for SLC17A2: Solute carrier family 17 (sodium phosphate), member 2 Hs.591802 [show with all ESTs]Unigene Representative Sequence: NM_0058353 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360488(uc011dkc.2) ENST00000265425 ENST00000377850(uc011dkb.2 uc003nfl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC17A2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC17A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC17A2 (NM_005835) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC17A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC17A2 |
Additional cDNA sequence: BC104822.1 BC112033.1 BC143317.1 BC143323.1 U90544.1 Y10505.1 Z83946.1 4 DOTS entries: DT.209014 DT.100728794 DT.121363350 DT.121363351 17 AceView cDNA sequences: C21035 NM_005835 U90544 CR598602 BX402791 AV653531 AV650042 BX382934 AA344831 Z83946 AU098925 Z83938 BX330773 H60423 AV650079 H60468 AU103847
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC17A2
|
Expression
for SLC17A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC17A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAAATAAA
About this image
See SLC17A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC17A2
SOURCE GeneReport for Unigene cluster: Hs.591802
UniProtKB/Swiss-Prot: NPT3_HUMAN, O00624Tissue specificity: Expressed in the small intestine, kidney, spleen and testis. Not detected in fetal brain, bonemarrow, and mammary gland
SABiosciences Custom PCR Arrays for SLC17A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC17A2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC17A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC17A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC17A2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A2 |
Orthologs
for SLC17A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC17A2 gene from 4/20 species (see all 20) About this table
ENSEMBL Gene Tree for SLC17A2 (if available)
TreeFam Gene Tree for SLC17A2 (if available) |
Paralogs
for SLC17A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC17A2 gene
- SLC17A72 SLC17A82 SLC17A62 SLC17A32 SLC17A12 SLC17A42 SLC17A52 SLC17A92
7 SIMAP similar genes for SLC17A2 using alignment to 2 protein entries: NPT3_HUMAN (see all proteins):SLC17A4 SLC17A1 SLC17A5 SLC17A3 SLC17A6 SLC17A7
SLC17A8
SLC17A2 for paralogs About GeneDecksing
|
Genomic Variants
for SLC17A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC17A2 (25912982 - 25930946 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC17A2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC17A2 |
|
Disorders
/ Diseases
for SLC17A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC17A2 for disorders About GeneDecksing
OMIM gene information: 611049
OMIM disorders: --
6  diseases for SLC17A2: About MalaCardsglycogen storage disease fanconi's anemia hypophosphatemia hemochromatosis
gout anemia
Human Genome Epidemiology (HuGE) Navigator: SLC17A2 (5 documents)
Export disorders for SLC17A2 gene to outside databases
|
Publications
for SLC17A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC17A2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC17A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PubMed id 9149941)1, 2, 3 Ruddy D.A.... Feder J.N. (1997)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Common polymorphisms influencing serum uric acid leve ls contribute to susceptibility to gout, but not to coronary artery disease. (PubMed id 19890391)1 Stark K....Hengstenberg C. (2009)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- [Role of the type 3 sodium-dependent phosphate transporter in the calcification of growth plate chondrocytes] (PubMed id 17012827)9 Sugita A....Yoneda T. (2006)
|
External Searches for SLC17A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC17A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC17A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC17A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC17A2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC17A2 gene:
Search GeneIP for patents involving SLC17A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC17A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC17A2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC17A2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC17A2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC17A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC17A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC17A2 |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC17A2 |
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