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Aliases for SLC17A1 Gene

Aliases for SLC17A1 Gene

  • Solute Carrier Family 17 (Organic Anion Transporter), Member 1 2 3
  • NPT1 3 4 6
  • Solute Carrier Family 17 (Sodium Phosphate), Member 1 2 3
  • Renal Sodium-Dependent Phosphate Transport Protein 1 3 4
  • Renal Na(+)-Dependent Phosphate Cotransporter 1 3 4
  • Renal Sodium-Phosphate Transport Protein 1 3 4
  • Solute Carrier Family 17 Member 1 3 4
  • Sodium/Phosphate Cotransporter 1 3 4
  • Na(+)/PI Cotransporter 1 3 4
  • Na/Pi-4 3 4
  • Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 1 3
  • Sodium-Dependent Phosphate Transport Protein 1 3
  • Sodium/Phosphate Type I Cotransporter 3
  • Sodium Phosphate Transporter 3
  • NAPI-1 3
  • NPT-1 3

External Ids for SLC17A1 Gene

Previous HGNC Symbols for SLC17A1 Gene

  • NPT1

Previous GeneCards Identifiers for SLC17A1 Gene

  • GC06M025840
  • GC06M025891

Summaries for SLC17A1 Gene

GeneCards Summary for SLC17A1 Gene

SLC17A1 (Solute Carrier Family 17 (Organic Anion Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC17A1 include cardiovascular disease risk factor. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and sodium-dependent phosphate transmembrane transporter activity. An important paralog of this gene is SLC17A8.

UniProtKB/Swiss-Prot for SLC17A1 Gene

  • Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane

Gene Wiki entry for SLC17A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC17A1 Gene

Genomics for SLC17A1 Gene

Regulatory Elements for SLC17A1 Gene

Genomic Location for SLC17A1 Gene

Start:
25,782,897 bp from pter
End:
25,832,059 bp from pter
Size:
49,163 bases
Orientation:
Minus strand

Genomic View for SLC17A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC17A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC17A1 Gene

Proteins for SLC17A1 Gene

  • Protein details for SLC17A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14916-NPT1_HUMAN
    Recommended name:
    Sodium-dependent phosphate transport protein 1
    Protein Accession:
    Q14916
    Secondary Accessions:
    • A8K418
    • O60761
    • Q13783
    • Q3MIP5
    • Q5MJP8
    • Q5TB83
    • Q96KL8

    Protein attributes for SLC17A1 Gene

    Size:
    467 amino acids
    Molecular mass:
    51132 Da
    Quaternary structure:
    • Interacts with PDZK1.
    SequenceCaution:
    • Sequence=BAA05888.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19543.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC17A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC17A1 Gene

Proteomics data for SLC17A1 Gene at MOPED

Post-translational modifications for SLC17A1 Gene

  • Glycosylation at Asn41, Asn49, and Asn58
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC17A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC17A1 Gene

Domains for SLC17A1 Gene

Gene Families for SLC17A1 Gene

Protein Domains for SLC17A1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14916

UniProtKB/Swiss-Prot:

NPT1_HUMAN :
  • Q14916
Family:
  • Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
genes like me logo Genes that share domains with SLC17A1: view

Function for SLC17A1 Gene

Molecular function for SLC17A1 Gene

GENATLAS Biochemistry: solute carrier family 17 (sodium/phosphate cotransport),member 1,expressed in kidney
UniProtKB/Swiss-Prot Function: Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane

Gene Ontology (GO) - Molecular Function for SLC17A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015114 phosphate ion transmembrane transporter activity --
GO:0015293 symporter activity IEA --
GO:0015321 sodium-dependent phosphate transmembrane transporter activity TAS 8867793
genes like me logo Genes that share ontologies with SLC17A1: view

Phenotypes for SLC17A1 Gene

genes like me logo Genes that share phenotypes with SLC17A1: view

Animal Model Products

CRISPR Products

miRNA for SLC17A1 Gene

miRTarBase miRNAs that target SLC17A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC17A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC17A1 Gene

Localization for SLC17A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC17A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC17A1 Gene COMPARTMENTS Subcellular localization image for SLC17A1 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC17A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8288239
GO:0016020 membrane TAS 8288239
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC17A1: view

Pathways for SLC17A1 Gene

genes like me logo Genes that share pathways with SLC17A1: view

Interacting Proteins for SLC17A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244527%0d%0a9606.ENSP00000262613%0d%0a
Selected Interacting proteins: ENSP00000244527 Q14916-NPT1_HUMAN for SLC17A1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC17A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport IEA --
GO:0006817 phosphate ion transport TAS 8867793
GO:0035435 phosphate ion transmembrane transport IEA --
GO:0044341 sodium-dependent phosphate transport TAS 8867793
genes like me logo Genes that share ontologies with SLC17A1: view

Compounds for SLC17A1 Gene

(2) HMDB Compounds for SLC17A1 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC17A1: view

Transcripts for SLC17A1 Gene

Unigene Clusters for SLC17A1 Gene

Solute carrier family 17 (sodium phosphate), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC17A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC17A1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC17A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3:

Relevant External Links for SLC17A1 Gene

GeneLoc Exon Structure for
SLC17A1
ECgene alternative splicing isoforms for
SLC17A1

Expression for SLC17A1 Gene

mRNA expression in normal human tissues for SLC17A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC17A1 Gene

This gene is overexpressed in Kidney - Cortex (40.8) and Liver (10.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC17A1 Gene

SOURCE GeneReport for Unigene cluster for SLC17A1 Gene Hs.205816

mRNA Expression by UniProt/SwissProt for SLC17A1 Gene

Q14916-NPT1_HUMAN
Tissue specificity: Expressed in kidney cortex, liver and brain but not in other tissues
genes like me logo Genes that share expressions with SLC17A1: view

In Situ Assay Products

Orthologs for SLC17A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC17A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC17A1 35
  • 99.36 (n)
  • 98.5 (a)
SLC17A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC17A1 35
  • 78.37 (n)
  • 62.53 (a)
SLC17A1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC17A1 35
  • 79.3 (n)
  • 69.81 (a)
SLC17A1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc17a1 35
  • 74.98 (n)
  • 65.59 (a)
Slc17a1 16
Slc17a1 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc17a1 35
  • 75.91 (n)
  • 66.02 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929219.1 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T09B9.2 37
  • 25 (a)
F21F8.11 37
  • 24 (a)
Species with no ortholog for SLC17A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC17A1 Gene

ENSEMBL:
Gene Tree for SLC17A1 (if available)
TreeFam:
Gene Tree for SLC17A1 (if available)

Paralogs for SLC17A1 Gene

Paralogs for SLC17A1 Gene

Selected SIMAP similar genes for SLC17A1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC17A1: view

Variants for SLC17A1 Gene

Sequence variations from dbSNP and Humsavar for SLC17A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3923 -- 25,783,087(-) GGGCC(A/G)GTTTT utr-variant-3-prime
rs765284 -- 25,828,113(-) GTTCC(A/C)CCATT intron-variant
rs765285 -- 25,828,014(-) taggc(C/G)cctct intron-variant
rs942377 -- 25,792,064(+) aagtt(C/T)aaaat intron-variant
rs942378 -- 25,812,231(+) GGCTG(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC17A1 Gene

Variant ID Type Subtype PubMed ID
nsv883489 CNV Gain 21882294

Relevant External Links for SLC17A1 Gene

HapMap Linkage Disequilibrium report
SLC17A1
Human Gene Mutation Database (HGMD)
SLC17A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC17A1 Gene

Disorders for SLC17A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC17A1 Gene including...

Search for SLC17A1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SLC17A1 Gene

Relevant External Links for SLC17A1

Genetic Association Database (GAD)
SLC17A1
Human Genome Epidemiology (HuGE) Navigator
SLC17A1
genes like me logo Genes that share disorders with SLC17A1: view

No data available for UniProtKB/Swiss-Prot for SLC17A1 Gene

Publications for SLC17A1 Gene

  1. Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. (PMID: 8288239) Chong S.S. … Hughes M.R. (Genomics 1993) 2 3 4 23
  2. Cloning and functional expression of a Na(+)-dependent phosphate co- transporter from human kidney: cDNA cloning and functional expression. (PMID: 7826357) Miyamoto K. … Takeda E. (Biochem. J. 1995) 3 4 23
  3. Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity. (PMID: 11704559) Soumounou Y. … Tenenhouse H.S. (Am. J. Physiol. 2001) 3 4
  4. Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts. (PMID: 8867793) Li H. … Xie Z. (Cell. Mol. Biol. Res. 1995) 3 23
  5. Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene. (PMID: 9545579) Taketani Y. … Takeda E. (Biochim. Biophys. Acta 1998) 3 4

Products for SLC17A1 Gene

Sources for SLC17A1 Gene

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