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Aliases for SLC16A9 Gene

Aliases for SLC16A9 Gene

  • Solute Carrier Family 16 Member 9 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 9 2 3
  • Monocarboxylic Acid Transporter 9 2 3
  • C10orf36 3 4
  • MCT 9 3 4
  • MCT9 3 4
  • Solute Carrier Family 16, Member 9 (Monocarboxylic Acid Transporter 9) 2
  • Chromosome 10 Open Reading Frame 36 2
  • Solute Carrier Family 16, Member 9 2
  • Monocarboxylate Transporter 9 3

External Ids for SLC16A9 Gene

Previous HGNC Symbols for SLC16A9 Gene

  • C10orf36

Previous GeneCards Identifiers for SLC16A9 Gene

  • GC10M060757
  • GC10M060755
  • GC10M061080
  • GC10M061410
  • GC10M055397

Summaries for SLC16A9 Gene

GeneCards Summary for SLC16A9 Gene

SLC16A9 (Solute Carrier Family 16 Member 9) is a Protein Coding gene. Diseases associated with SLC16A9 include Gout. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A14.

UniProtKB/Swiss-Prot for SLC16A9 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Gene Wiki entry for SLC16A9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A9 Gene

Genomics for SLC16A9 Gene

Regulatory Elements for SLC16A9 Gene

Enhancers for SLC16A9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F059748 1.2 ENCODE 18.8 -13.1 -13076 0.9 JUNB REST SLC16A9 MRLN
GH10F059750 0.5 ENCODE 18.8 -14.7 -14736 0.2 SLC16A9 MRLN
GH10F059778 0.2 ENCODE 17.4 -44.0 -44004 2.1 CEBPB ZBTB8A REST SLC16A9 CCDC6 MRLN
GH10F059648 0.8 ENCODE 15.8 +87.1 87094 1.3 PKNOX1 BACH1 CEBPG ZNF644 ZNF316 GATA3 NFE2 FOS MAFK NFE2L2 SLC16A9 CCDC6 GC10P059652 LOC105378319
GH10F059700 0.4 ENCODE 11.6 +35.1 35105 0.2 CTCF ZKSCAN8 SLC16A9 GC10P059652
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC16A9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC16A9 Gene

Chromosome:
10
Start:
59,650,761 bp from pter
End:
59,736,002 bp from pter
Size:
85,242 bases
Orientation:
Minus strand

Genomic View for SLC16A9 Gene

Genes around SLC16A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A9 Gene

Proteins for SLC16A9 Gene

  • Protein details for SLC16A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY1-MOT9_HUMAN
    Recommended name:
    Monocarboxylate transporter 9
    Protein Accession:
    Q7RTY1
    Secondary Accessions:
    • Q6ZMI2
    • Q9UFH8

    Protein attributes for SLC16A9 Gene

    Size:
    509 amino acids
    Molecular mass:
    55794 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18743.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC16A9 Gene

Post-translational modifications for SLC16A9 Gene

  • Ubiquitination at Lys 504
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC16A9 Gene

Domains & Families for SLC16A9 Gene

Gene Families for SLC16A9 Gene

Protein Domains for SLC16A9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTY1

UniProtKB/Swiss-Prot:

MOT9_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A9: view

Function for SLC16A9 Gene

Molecular function for SLC16A9 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Gene Ontology (GO) - Molecular Function for SLC16A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A9: view
genes like me logo Genes that share phenotypes with SLC16A9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A9

miRNA for SLC16A9 Gene

miRTarBase miRNAs that target SLC16A9

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A9 Gene

Localization for SLC16A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A9 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A9 Gene COMPARTMENTS Subcellular localization image for SLC16A9 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC16A9: view

Pathways & Interactions for SLC16A9 Gene

SuperPathways for SLC16A9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC16A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport IEA --
GO:0046415 urate metabolic process IMP 19503597
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A9: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A9 Gene

Transcripts for SLC16A9 Gene

Unigene Clusters for SLC16A9 Gene

Solute carrier family 16, member 9 (monocarboxylic acid transporter 9):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6:

Relevant External Links for SLC16A9 Gene

GeneLoc Exon Structure for
SLC16A9
ECgene alternative splicing isoforms for
SLC16A9

Expression for SLC16A9 Gene

mRNA expression in normal human tissues for SLC16A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A9 Gene

This gene is overexpressed in Adrenal Gland (x13.4) and Kidney - Cortex (x5.9).

Protein differential expression in normal tissues from HIPED for SLC16A9 Gene

This gene is overexpressed in Urine (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A9 Gene



Protein tissue co-expression partners for SLC16A9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC16A9 Gene:

SLC16A9

SOURCE GeneReport for Unigene cluster for SLC16A9 Gene:

Hs.499709
genes like me logo Genes that share expression patterns with SLC16A9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC16A9 Gene

Orthologs for SLC16A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A9 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia SLC16A9 34 35
  • 90.83 (n)
cow
(Bos Taurus)
Mammalia SLC16A9 34 35
  • 90.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A9 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a9 34 16 35
  • 82.61 (n)
rat
(Rattus norvegicus)
Mammalia LOC687808 34
  • 79.56 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A9 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A9 34 35
  • 76.96 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A9 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485780 34
  • 63.41 (n)
zebrafish
(Danio rerio)
Actinopterygii slc16a9a 34 35
  • 58.58 (n)
slc16a9b 35
  • 51 (a)
OneToMany
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001782 34
  • 46.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for SLC16A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A9 Gene

ENSEMBL:
Gene Tree for SLC16A9 (if available)
TreeFam:
Gene Tree for SLC16A9 (if available)

Paralogs for SLC16A9 Gene

(4) SIMAP similar genes for SLC16A9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC16A9: view

Variants for SLC16A9 Gene

Sequence variations from dbSNP and Humsavar for SLC16A9 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001311 -- 59,701,772(+) CCCTC(A/G)TCCAA intron-variant
rs10465988 -- 59,655,644(+) ACACA(C/G)AGGGT intron-variant
rs10466044 -- 59,653,357(+) gaagg(C/T)ggagc intron-variant
rs10466045 -- 59,653,387(+) cgcaa(C/T)tgcac intron-variant
rs10466046 -- 59,653,578(+) TTTTG(C/T)ACAAA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC16A9 Gene

Variant ID Type Subtype PubMed ID
dgv462n106 CNV deletion 24896259
esv1583704 CNV deletion 17803354
esv2613224 CNV deletion 19546169
esv2674517 CNV deletion 23128226
esv2737462 CNV deletion 23290073
esv3623459 CNV loss 21293372
esv3891831 CNV loss 25118596
nsv473192 CNV novel sequence insertion 20440878
nsv819969 CNV loss 19587683
nsv825405 CNV loss 20364138
nsv955979 CNV deletion 24416366

Variation tolerance for SLC16A9 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A9 Gene

Human Gene Mutation Database (HGMD)
SLC16A9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A9 Gene

Disorders for SLC16A9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gout
  • articular gout
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC16A9

Genetic Association Database (GAD)
SLC16A9
Human Genome Epidemiology (HuGE) Navigator
SLC16A9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A9
genes like me logo Genes that share disorders with SLC16A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A9 Gene

Publications for SLC16A9 Gene

  1. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K. … Gieger C. (Nature 2011) 3 46 64
  2. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. (PMID: 19861489) van der Harst P. … Navis G. (Hum. Mol. Genet. 2010) 3 46 64
  3. A genome-wide perspective of genetic variation in human metabolism. (PMID: 20037589) Illig T. … Suhre K. (Nat. Genet. 2010) 3 46 64
  4. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. (PMID: 19503597) Kolz M. … Gieger C. (PLoS Genet. 2009) 3 46 64
  5. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PMID: 19890391) Stark K. … Hengstenberg C. (PLoS ONE 2009) 3 46 64

Products for SLC16A9 Gene

Sources for SLC16A9 Gene

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