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Aliases for SLC16A8 Gene

Aliases for SLC16A8 Gene

  • Solute Carrier Family 16 Member 8 2 3 4
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 8 2 3 5
  • Solute Carrier 16 (Monocarboxylic Acid Transporters), Member 8 2 3
  • MCT 3 3 4
  • MCT3 3 4
  • Solute Carrier Family 16, Member 8 (Monocarboxylic Acid Transporter 3) 3
  • Monocarboxylate Transporter 3 2
  • REMP 3

External Ids for SLC16A8 Gene

Previous GeneCards Identifiers for SLC16A8 Gene

  • GC22M035088
  • GC22M036717
  • GC22M036798
  • GC22M038474
  • GC22M021438
  • GC22M038393
  • GC22M038515

Summaries for SLC16A8 Gene

Entrez Gene Summary for SLC16A8 Gene

  • SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SLC16A8 Gene

SLC16A8 (Solute Carrier Family 16 Member 8) is a Protein Coding gene. Diseases associated with SLC16A8 include Macular Degeneration, Age-Related, 1. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Platelet activation, signaling and aggregation. GO annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A8 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A8 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A8 Gene

Genomics for SLC16A8 Gene

Regulatory Elements for SLC16A8 Gene

Enhancers for SLC16A8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC16A8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC16A8 Gene

Chromosome:
22
Start:
38,078,134 bp from pter
End:
38,084,093 bp from pter
Size:
5,960 bases
Orientation:
Minus strand

Genomic View for SLC16A8 Gene

Genes around SLC16A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A8 Gene

Proteins for SLC16A8 Gene

  • Protein details for SLC16A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95907-MOT3_HUMAN
    Recommended name:
    Monocarboxylate transporter 3
    Protein Accession:
    O95907
    Secondary Accessions:
    • Q9UBE2

    Protein attributes for SLC16A8 Gene

    Size:
    504 amino acids
    Molecular mass:
    52319 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A8 Gene

Proteomics data for SLC16A8 Gene at MOPED

Post-translational modifications for SLC16A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC16A8 Gene

Domains & Families for SLC16A8 Gene

Gene Families for SLC16A8 Gene

Protein Domains for SLC16A8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95907

UniProtKB/Swiss-Prot:

MOT3_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A8: view

Function for SLC16A8 Gene

Molecular function for SLC16A8 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015129 lactate transmembrane transporter activity EXP,IEA 15917240
genes like me logo Genes that share ontologies with SLC16A8: view
genes like me logo Genes that share phenotypes with SLC16A8: view

Animal Models for SLC16A8 Gene

MGI Knock Outs for SLC16A8:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A8

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC16A8 Gene

Localization for SLC16A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A8 Gene COMPARTMENTS Subcellular localization image for SLC16A8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009925 basal plasma membrane IEA --
GO:0016020 membrane TAS 10493836
genes like me logo Genes that share ontologies with SLC16A8: view

Pathways & Interactions for SLC16A8 Gene

genes like me logo Genes that share pathways with SLC16A8: view

Gene Ontology (GO) - Biological Process for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0015727 lactate transport TAS 10493836
GO:0044237 cellular metabolic process TAS --
GO:0050900 leukocyte migration TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A8: view

No data available for SIGNOR curated interactions for SLC16A8 Gene

Drugs & Compounds for SLC16A8 Gene

(1) Drugs for SLC16A8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0

(4) Additional Compounds for SLC16A8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AR-C155858
496791-37-8
CHC
28166-41-8
SR 13800
227321-12-2
UK 5099
56396-35-1

(4) Tocris Compounds for SLC16A8 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1
genes like me logo Genes that share compounds with SLC16A8: view

Transcripts for SLC16A8 Gene

mRNA/cDNA for SLC16A8 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC16A8 Gene

Solute carrier family 16, member 8 (monocarboxylic acid transporter 3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A8 Gene

No ASD Table

Relevant External Links for SLC16A8 Gene

GeneLoc Exon Structure for
SLC16A8
ECgene alternative splicing isoforms for
SLC16A8

Expression for SLC16A8 Gene

mRNA expression in normal human tissues for SLC16A8 Gene

Protein differential expression in normal tissues from HIPED for SLC16A8 Gene

This gene is overexpressed in Monocytes (36.6) and Tlymphocyte (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A8 Gene



SOURCE GeneReport for Unigene cluster for SLC16A8 Gene Hs.745256

mRNA Expression by UniProt/SwissProt for SLC16A8 Gene

O95907-MOT3_HUMAN
Tissue specificity: Retinal pigment epithelium.
genes like me logo Genes that share expression patterns with SLC16A8: view

Protein tissue co-expression partners for SLC16A8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC16A8 Gene

Orthologs for SLC16A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC16A8 35
  • 87.09 (n)
  • 87.58 (a)
SLC16A8 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A8 35
  • 88.03 (n)
  • 87.08 (a)
SLC16A8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a8 35
  • 83.61 (n)
  • 86.67 (a)
Slc16a8 16
Slc16a8 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC16A8 35
  • 99.34 (n)
  • 99.21 (a)
SLC16A8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a8 35
  • 83.68 (n)
  • 87.29 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC16A8 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A8 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A8 35
  • 65.42 (n)
  • 64.37 (a)
SLC16A3 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A8 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC557884 35
  • 59.18 (n)
  • 63.27 (a)
slc16a8 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13907 37
  • 36 (a)
CG8271 37
  • 38 (a)
Species with no ortholog for SLC16A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A8 Gene

ENSEMBL:
Gene Tree for SLC16A8 (if available)
TreeFam:
Gene Tree for SLC16A8 (if available)

Paralogs for SLC16A8 Gene

(10) SIMAP similar genes for SLC16A8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC16A8: view

Variants for SLC16A8 Gene

Sequence variations from dbSNP and Humsavar for SLC16A8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_053654 -
VAR_060107 -

Structural Variations from Database of Genomic Variants (DGV) for SLC16A8 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294
nsv915053 CNV Loss 21882294
nsv834193 CNV Loss 17160897
nsv915054 CNV Loss 21882294
dgv4968n71 CNV Loss 21882294
nsv471198 CNV Loss 18288195
dgv4969n71 CNV Loss 21882294
nsv834194 CNV Loss 17160897
nsv527871 CNV Loss 19592680

Variation tolerance for SLC16A8 Gene

Gene Damage Index Score: 8.83; 86.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC16A8 Gene

Disorders for SLC16A8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
macular degeneration, age-related, 1
  • macular degeneration, age-related, 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC16A8

Genetic Association Database (GAD)
SLC16A8
Human Genome Epidemiology (HuGE) Navigator
SLC16A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A8
genes like me logo Genes that share disorders with SLC16A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A8 Gene

Publications for SLC16A8 Gene

  1. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. (PMID: 10493836) Yoon H. … Philp N.J. (Genomics 1999) 2 3 4 23 67
  2. Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development. (PMID: 16514190) Jansen S. … Kaye P.L. (Reproduction 2006) 25 26
  3. Seven new loci associated with age-related macular degeneration. (PMID: 23455636) Fritsche L.G. … Abecasis G.R. (Nat. Genet. 2013) 3
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3
  5. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). (PMID: 15917240) Wilson M.C. … Halestrap A.P. (J. Biol. Chem. 2005) 3

Products for SLC16A8 Gene

Sources for SLC16A8 Gene

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