Aliases for SLC16A8 Gene
- Solute Carrier Family 16 Member 8 2 3 4 5
- Solute Carrier Family 16 (Monocarboxylate Transporter), Member 8 2 3
- Solute Carrier 16 (Monocarboxylic Acid Transporters), Member 8 2 3
- Monocarboxylate Transporter 3 2 3
- MCT 3 3 4
- MCT3 3 4
- Solute Carrier Family 16, Member 8 (Monocarboxylic Acid Transporter 3) 3
- REMP 3
External Ids for SLC16A8 Gene
Previous GeneCards Identifiers for SLC16A8 Gene
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
GeneCards Summary for SLC16A8 Gene
SLC16A8 (Solute Carrier Family 16 Member 8) is a Protein Coding gene. Diseases associated with SLC16A8 include Atypical Depressive Disorder and Macular Degeneration, Age-Related, 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A3.
UniProtKB/Swiss-Prot for SLC16A8 Gene
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.