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Aliases for SLC16A8 Gene

Aliases for SLC16A8 Gene

  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 8 2 3
  • Solute Carrier 16 (Monocarboxylic Acid Transporters), Member 8 2 3
  • Solute Carrier Family 16 Member 8 3 4
  • Monocarboxylate Transporter 3 2 3
  • MCT 3 3 4
  • MCT3 3 4
  • Solute Carrier Family 16, Member 8 (Monocarboxylic Acid Transporter 3) 3
  • REMP 3

External Ids for SLC16A8 Gene

Summaries for SLC16A8 Gene

Entrez Gene Summary for SLC16A8 Gene

  • SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SLC16A8 Gene

SLC16A8 (Solute Carrier Family 16 (Monocarboxylate Transporter), Member 8) is a Protein Coding gene. Among its related pathways are Hemostasis and Metabolism. GO annotations related to this gene include symporter activity and lactate transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A8 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A8 Gene

Genomics for SLC16A8 Gene

Genomic Location for SLC16A8 Gene

Start:
38,078,134 bp from pter
End:
38,084,093 bp from pter
Size:
5,960 bases
Orientation:
Minus strand

Genomic View for SLC16A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC16A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A8 Gene

Regulatory Elements for SLC16A8 Gene

Proteins for SLC16A8 Gene

  • Protein details for SLC16A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95907-MOT3_HUMAN
    Recommended name:
    Monocarboxylate transporter 3
    Protein Accession:
    O95907
    Secondary Accessions:
    • Q9UBE2

    Protein attributes for SLC16A8 Gene

    Size:
    504 amino acids
    Molecular mass:
    52319 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A8 Gene

Proteomics data for SLC16A8 Gene at MOPED

Post-translational modifications for SLC16A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC16A8 Gene

Domains for SLC16A8 Gene

Gene Families for SLC16A8 Gene

Protein Domains for SLC16A8 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MOT3_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.:
    • O95907
genes like me logo Genes that share domains with SLC16A8: view

Function for SLC16A8 Gene

Molecular function for SLC16A8 Gene

UniProtKB/Swiss-Prot Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015129 lactate transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0015355 secondary active monocarboxylate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A8: view

Phenotypes for SLC16A8 Gene

MGI mutant phenotypes for SLC16A8:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC16A8:
genes like me logo Genes that share phenotypes with SLC16A8: view

Animal Models for SLC16A8 Gene

MGI Knock Outs for SLC16A8:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC16A8 Gene

Localization for SLC16A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A8 Gene COMPARTMENTS Subcellular localization image for SLC16A8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane TAS 10493836
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC16A8: view

Pathways for SLC16A8 Gene

genes like me logo Genes that share pathways with SLC16A8: view

Gene Ontology (GO) - Biological Process for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0007596 blood coagulation TAS --
GO:0015711 organic anion transport --
GO:0015727 lactate transport TAS 10493836
GO:0035873 lactate transmembrane transport --
genes like me logo Genes that share ontologies with SLC16A8: view

Compounds for SLC16A8 Gene

(1) HMDB Compounds for SLC16A8 Gene

Compound Synonyms Cas Number PubMed IDs
Pyruvic acid
  • 2-Oxopropanoate
127-17-3

(1) Drugbank Compounds for SLC16A8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyruvic acid
  • 2-Oxopropanoate
127-17-3 target
genes like me logo Genes that share compounds with SLC16A8: view

Transcripts for SLC16A8 Gene

mRNA/cDNA for SLC16A8 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC16A8 Gene

Solute carrier family 16, member 8 (monocarboxylic acid transporter 3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A8 Gene

No ASD Table

Relevant External Links for SLC16A8 Gene

GeneLoc Exon Structure for
SLC16A8
ECgene alternative splicing isoforms for
SLC16A8

Expression for SLC16A8 Gene

mRNA expression in normal human tissues for SLC16A8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC16A8 Gene

SOURCE GeneReport for Unigene cluster for SLC16A8 Gene Hs.745256

mRNA Expression by UniProt/SwissProt for SLC16A8 Gene

O95907-MOT3_HUMAN
Tissue specificity: Retinal pigment epithelium
genes like me logo Genes that share expressions with SLC16A8: view

Orthologs for SLC16A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A8 36
  • 99.34 (n)
  • 99.21 (a)
SLC16A8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC16A8 36
  • 87.09 (n)
  • 87.58 (a)
SLC16A8 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A8 36
  • 88.03 (n)
  • 87.08 (a)
SLC16A8 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a8 36
  • 83.61 (n)
  • 86.67 (a)
Slc16a8 16
Slc16a8 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A8 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A8 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a8 36
  • 83.68 (n)
  • 87.29 (a)
chicken
(Gallus gallus)
Aves SLC16A3 37
  • 58 (a)
OneToOne
SLC16A8 36
  • 65.42 (n)
  • 64.37 (a)
lizard
(Anolis carolinensis)
Reptilia SLC16A8 37
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC557884 36
  • 59.18 (n)
  • 63.27 (a)
slc16a8 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8271 38
  • 38 (a)
CG13907 38
  • 36 (a)
Species with no ortholog for SLC16A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A8 Gene

ENSEMBL:
Gene Tree for SLC16A8 (if available)
TreeFam:
Gene Tree for SLC16A8 (if available)

Paralogs for SLC16A8 Gene

Selected SIMAP similar genes for SLC16A8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC16A8: view

Variants for SLC16A8 Gene

Sequence variations from dbSNP and Humsavar for SLC16A8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1004763 -- 38,078,945(-) CACCA(A/G)AAGCC intron-variant
rs1004764 -- 38,078,845(-) TAAAA(C/T)AGGAA intron-variant
rs2012859 -- 38,077,699(+) AGCAA(A/G)GAAGT downstream-variant-500B
rs2012867 -- 38,077,805(-) CAACT(A/C)GGGTT downstream-variant-500B
rs2076371 - 38,078,689(+) TCAAC(A/G)CATCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SLC16A8 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294
nsv915053 CNV Loss 21882294
nsv834193 CNV Loss 17160897
nsv915054 CNV Loss 21882294
dgv4968n71 CNV Loss 21882294
nsv471198 CNV Loss 18288195
dgv4969n71 CNV Loss 21882294
nsv834194 CNV Loss 17160897
nsv527871 CNV Loss 19592680

Relevant External Links for SLC16A8 Gene

HapMap Linkage Disequilibrium report
SLC16A8

Disorders for SLC16A8 Gene

Relevant External Links for SLC16A8

Genetic Association Database (GAD)
SLC16A8
Human Genome Epidemiology (HuGE) Navigator
SLC16A8
genes like me logo Genes that share disorders with SLC16A8: view

No data available for UniProtKB/Swiss-Prot for SLC16A8 Gene

Publications for SLC16A8 Gene

  1. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. (PMID: 10493836) Yoon H. … Philp N.J. (Genomics 1999) 2 3 4 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 49
  4. Seven new loci associated with age-related macular degeneration. (PMID: 23455636) Fritsche L.G. … Abecasis G.R. (Nat. Genet. 2013) 3
  5. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. (PMID: 12657613) Philp N.J. … Hjelmeland L.M. (Invest. Ophthalmol. Vis. Sci. 2003) 3

Products for SLC16A8 Gene

  • antibodies-online peptides for SLC16A8
  • antibodies-online antibodies for SLC16A8
  • antibodies-online kits for SLC16A8

Sources for SLC16A8 Gene

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