Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC16A8 Gene

Aliases for SLC16A8 Gene

  • Solute Carrier Family 16 Member 8 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 8 2 3
  • Solute Carrier 16 (Monocarboxylic Acid Transporters), Member 8 2 3
  • Monocarboxylate Transporter 3 2 3
  • MCT 3 3 4
  • MCT3 3 4
  • Solute Carrier Family 16, Member 8 (Monocarboxylic Acid Transporter 3) 3
  • REMP 3

External Ids for SLC16A8 Gene

Previous GeneCards Identifiers for SLC16A8 Gene

  • GC22M035088
  • GC22M036717
  • GC22M036798
  • GC22M038474
  • GC22M021438
  • GC22M038393
  • GC22M038515
  • GC22M038827
  • GC22M039964
  • GC22M040655
  • GC22M041104
  • GC22M041507

Summaries for SLC16A8 Gene

Entrez Gene Summary for SLC16A8 Gene

  • SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SLC16A8 Gene

SLC16A8 (Solute Carrier Family 16 Member 8) is a Protein Coding gene. Diseases associated with SLC16A8 include Atypical Depressive Disorder and Macular Degeneration, Age-Related, 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A3.

UniProtKB/Swiss-Prot for SLC16A8 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A8 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

Additional gene information for SLC16A8 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A8 Gene

Genomics for SLC16A8 Gene

GeneHancer (GH) Regulatory Elements for SLC16A8 Gene

Promoters and enhancers for SLC16A8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I037993 Enhancer 1.5 VISTA ENCODE dbSUPER 10 +87.0 86978 7.8 PKNOX1 FEZF1 ZNF2 GLIS2 FOS SMARCB1 ZNF623 GLIS1 PRDM4 WT1 SLC16A8 GALR3 TRIOBP BAIAP2L2 KDELR3 MIR4534 GC22P038026 POLR2F ENSG00000279010
GH22I038107 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 5.6 -26.2 -26189 5.9 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 GLIS2 RXRA SP5 ZHX2 BAIAP2L2 PLA2G6 ANKRD54 PICK1 SLC16A8 ENSG00000272669 ENSG00000272720
GH22I038193 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.7 -109.6 -109616 1 HDAC1 FOXA2 PKNOX1 ARNT THRB RAD21 RARA YY1 ZNF766 ATF7 GC22P038194 SLC16A8 PLA2G6 ENSG00000279080
GH22I038062 Enhancer 0.7 FANTOM5 ENCODE dbSUPER 6.2 +21.1 21126 0.3 BAIAP2L2 SLC16A8 SOX10 PICK1 PLA2G6 ENSG00000233739
GH22I038191 Enhancer 0.9 ENCODE dbSUPER 4.6 -108.3 -108267 1.4 ELF3 SAP130 MAX ZNF16 ELF1 RARA TEAD3 JUND ATF3 KLF16 EIF3L H1F0 BAIAP2L2 SUN2 SLC16A8 GC22P038194 PLA2G6 ENSG00000279080
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC16A8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC16A8 gene promoter:

Genomic Locations for SLC16A8 Gene

Genomic Locations for SLC16A8 Gene
chr22:38,078,134-38,084,093
(GRCh38/hg38)
Size:
5,960 bases
Orientation:
Minus strand
chr22:38,474,141-38,480,100
(GRCh37/hg19)

Genomic View for SLC16A8 Gene

Genes around SLC16A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A8 Gene

Proteins for SLC16A8 Gene

  • Protein details for SLC16A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95907-MOT3_HUMAN
    Recommended name:
    Monocarboxylate transporter 3
    Protein Accession:
    O95907
    Secondary Accessions:
    • Q9UBE2

    Protein attributes for SLC16A8 Gene

    Size:
    504 amino acids
    Molecular mass:
    52319 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A8 Gene

Post-translational modifications for SLC16A8 Gene

No Post-translational modifications

Other Protein References for SLC16A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC16A8 Gene

Domains & Families for SLC16A8 Gene

Gene Families for SLC16A8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A8 Gene

Suggested Antigen Peptide Sequences for SLC16A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95907

UniProtKB/Swiss-Prot:

MOT3_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A8: view

Function for SLC16A8 Gene

Molecular function for SLC16A8 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Phenotypes From GWAS Catalog for SLC16A8 Gene

Gene Ontology (GO) - Molecular Function for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS,IEA --
GO:0015129 lactate transmembrane transporter activity EXP,IEA 15917240
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A8: view
genes like me logo Genes that share phenotypes with SLC16A8: view

Animal Models for SLC16A8 Gene

MGI Knock Outs for SLC16A8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC16A8 Gene

Localization for SLC16A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A8 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA,TAS 10493836
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with SLC16A8: view

Pathways & Interactions for SLC16A8 Gene

genes like me logo Genes that share pathways with SLC16A8: view

Gene Ontology (GO) - Biological Process for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport IEA --
GO:0015727 lactate transport TAS 10493836
GO:0035873 lactate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A8: view

No data available for SIGNOR curated interactions for SLC16A8 Gene

Drugs & Compounds for SLC16A8 Gene

(3) Drugs for SLC16A8 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved, Investigational Nutra Target 0
AR-C155858 Pharma MCT1 and MCT2 inhibitor, MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 0
UK-5099 Pharma MCTs and MPC inhibitor, MCT inhibitor; also inhibits of pyruvate transport 0

(1) Additional Compounds for SLC16A8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 13800
227321-12-2

(4) Tocris Compounds for SLC16A8 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1
genes like me logo Genes that share compounds with SLC16A8: view

Transcripts for SLC16A8 Gene

mRNA/cDNA for SLC16A8 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC16A8 Gene

Solute carrier family 16, member 8 (monocarboxylic acid transporter 3):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A8 Gene

No ASD Table

Relevant External Links for SLC16A8 Gene

GeneLoc Exon Structure for
SLC16A8
ECgene alternative splicing isoforms for
SLC16A8

Expression for SLC16A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A8 Gene

Protein differential expression in normal tissues from HIPED for SLC16A8 Gene

This gene is overexpressed in Monocytes (36.6) and Tlymphocyte (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A8 Gene



Protein tissue co-expression partners for SLC16A8 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC16A8 Gene:

SLC16A8

SOURCE GeneReport for Unigene cluster for SLC16A8 Gene:

Hs.745256

mRNA Expression by UniProt/SwissProt for SLC16A8 Gene:

O95907-MOT3_HUMAN
Tissue specificity: Retinal pigment epithelium.
genes like me logo Genes that share expression patterns with SLC16A8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A8 Gene

Orthologs for SLC16A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A8 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia SLC16A8 33 34
  • 88.03 (n)
cow
(Bos Taurus)
Mammalia SLC16A8 33 34
  • 87.09 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a8 33
  • 83.68 (n)
mouse
(Mus musculus)
Mammalia Slc16a8 33 16 34
  • 83.61 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A8 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A8 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A8 33
  • 65.42 (n)
SLC16A3 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A8 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc16a8 34
  • 62 (a)
OneToOne
LOC557884 33
  • 59.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8271 35
  • 38 (a)
CG13907 35
  • 36 (a)
Species where no ortholog for SLC16A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A8 Gene

ENSEMBL:
Gene Tree for SLC16A8 (if available)
TreeFam:
Gene Tree for SLC16A8 (if available)

Paralogs for SLC16A8 Gene

(10) SIMAP similar genes for SLC16A8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC16A8: view

Variants for SLC16A8 Gene

Sequence variations from dbSNP and Humsavar for SLC16A8 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs8135665 not-provided, not provided 38,080,269(-) C/T intron_variant
rs1000207978 -- 38,082,187(-) G/A intron_variant
rs1000302957 -- 38,082,372(-) GGGGG/GGGGGG intron_variant
rs1000372195 -- 38,077,714(-) T/C downstream_transcript_variant
rs1000531063 -- 38,082,401(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A8 Gene

Variant ID Type Subtype PubMed ID
nsv471198 CNV loss 18288195
nsv476631 CNV novel sequence insertion 20440878
nsv527871 CNV loss 19592680
nsv834193 CNV loss 17160897
nsv834194 CNV loss 17160897

Variation tolerance for SLC16A8 Gene

Gene Damage Index Score: 8.83; 86.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A8 Gene

Human Gene Mutation Database (HGMD)
SLC16A8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A8 Gene

Disorders for SLC16A8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC16A8 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
atypical depressive disorder
  • atypical depression
macular degeneration, age-related, 1
  • armd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC16A8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC16A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A8 Gene

Publications for SLC16A8 Gene

  1. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. (PMID: 10493836) Yoon H … Philp NJ (Genomics 1999) 2 3 4 22 58
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  4. Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases. (PMID: 27966779) Sharma K … Anand A (Journal of cellular biochemistry 2017) 3 58
  5. Seven new loci associated with age-related macular degeneration. (PMID: 23455636) Fritsche LG … AMD Gene Consortium (Nature genetics 2013) 3 58

Products for SLC16A8 Gene

Sources for SLC16A8 Gene

Content
Loading form....