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Aliases for SLC16A7 Gene

Aliases for SLC16A7 Gene

  • Solute Carrier Family 16 Member 7 2 3 4
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 7 2 3 5
  • MCT2 3 4
  • Solute Carrier Family 16, Member 7 (Monocarboxylic Acid Transporter 2) 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 7 2
  • MCT 2 4

External Ids for SLC16A7 Gene

Previous GeneCards Identifiers for SLC16A7 Gene

  • GC12P059779
  • GC12P060132
  • GC12P058276
  • GC12P058369
  • GC12P057131
  • GC12P059989

Summaries for SLC16A7 Gene

Entrez Gene Summary for SLC16A7 Gene

  • This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SLC16A7 Gene

SLC16A7 (Solute Carrier Family 16 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A7 Gene

  • Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.

Tocris Summary for SLC16A7 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A7 Gene

Genomics for SLC16A7 Gene

Regulatory Elements for SLC16A7 Gene

Enhancers for SLC16A7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC16A7 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC16A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC16A7 Gene

Chromosome:
12
Start:
59,595,934 bp from pter
End:
59,789,855 bp from pter
Size:
193,922 bases
Orientation:
Plus strand

Genomic View for SLC16A7 Gene

Genes around SLC16A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A7 Gene

Proteins for SLC16A7 Gene

  • Protein details for SLC16A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60669-MOT2_HUMAN
    Recommended name:
    Monocarboxylate transporter 2
    Protein Accession:
    O60669
    Secondary Accessions:
    • Q8NEM3
    • Q9UPB3

    Protein attributes for SLC16A7 Gene

    Size:
    478 amino acids
    Molecular mass:
    52200 Da
    Quaternary structure:
    • Interacts with GRID2IP.

neXtProt entry for SLC16A7 Gene

Proteomics data for SLC16A7 Gene at MOPED

Post-translational modifications for SLC16A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for MCT2

No data available for DME Specific Peptides for SLC16A7 Gene

Domains & Families for SLC16A7 Gene

Gene Families for SLC16A7 Gene

Protein Domains for SLC16A7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60669

UniProtKB/Swiss-Prot:

MOT2_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A7: view

Function for SLC16A7 Gene

Molecular function for SLC16A7 Gene

GENATLAS Biochemistry:
solute carrier family 16,member A7,monocarboxylic acids transporter,high affinity pyruvate transporter,restricted in normal tissues,widely expressed in cancer cell lines
UniProtKB/Swiss-Prot Function:
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.

Gene Ontology (GO) - Molecular Function for SLC16A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IEA,TAS --
GO:0015129 lactate transmembrane transporter activity IDA 9786900
genes like me logo Genes that share ontologies with SLC16A7: view
genes like me logo Genes that share phenotypes with SLC16A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A7

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A7 Gene

Localization for SLC16A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A7 Gene COMPARTMENTS Subcellular localization image for SLC16A7 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC16A7 Gene

Pathways & Interactions for SLC16A7 Gene

genes like me logo Genes that share pathways with SLC16A7: view

Interacting Proteins for SLC16A7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261187%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000457881%0d%0a
Selected Interacting proteins: ENSP00000261187 O60669-MOT2_HUMAN for SLC16A7 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC16A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A7: view

No data available for SIGNOR curated interactions for SLC16A7 Gene

Drugs & Compounds for SLC16A7 Gene

(13) Drugs for SLC16A7 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gamma Hydroxybutyric Acid Approved, Illicit Pharma Transporter, inhibitor 0
Niflumic Acid Approved Pharma Channel blocker, Transporter, inhibitor Ca2+-activated Cl- channel blocker 0
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 27
Pyruvic acid Approved Nutra Target, Transporter, substrate, inhibitor 0
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR, Cytotoxic agent 1466

(7) Additional Compounds for SLC16A7 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AR-C155858
496791-37-8
CHC
28166-41-8
SR 13800
227321-12-2
UK 5099
56396-35-1

(4) Tocris Compounds for SLC16A7 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1
genes like me logo Genes that share compounds with SLC16A7: view

Transcripts for SLC16A7 Gene

Unigene Clusters for SLC16A7 Gene

Solute carrier family 16, member 7 (monocarboxylic acid transporter 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A7 Gene

No ASD Table

Relevant External Links for SLC16A7 Gene

GeneLoc Exon Structure for
SLC16A7
ECgene alternative splicing isoforms for
SLC16A7

Expression for SLC16A7 Gene

mRNA expression in normal human tissues for SLC16A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A7 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7).

Protein differential expression in normal tissues from HIPED for SLC16A7 Gene

This gene is overexpressed in Pancreas (13.2), Frontal cortex (11.3), Heart (8.7), Kidney (7.3), and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLC16A7 Gene



SOURCE GeneReport for Unigene cluster for SLC16A7 Gene Hs.88156

mRNA Expression by UniProt/SwissProt for SLC16A7 Gene

O60669-MOT2_HUMAN
Tissue specificity: Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.
genes like me logo Genes that share expression patterns with SLC16A7: view

Primer Products

No data available for Protein tissue co-expression partners for SLC16A7 Gene

Orthologs for SLC16A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC16A7 35
  • 82.2 (n)
  • 81.18 (a)
SLC16A7 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A7 35
  • 83.82 (n)
  • 82.56 (a)
SLC16A7 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a7 35
  • 77.44 (n)
  • 74.62 (a)
Slc16a7 16
Slc16a7 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC16A7 35
  • 99.86 (n)
  • 100 (a)
SLC16A7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a7 35
  • 77.51 (n)
  • 74.24 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC16A7 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A7 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A7 35
  • 72.96 (n)
  • 73.97 (a)
SLC16A7 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A7 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a7 35
  • 69.58 (n)
  • 72.65 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:165507 35
  • 66.93 (n)
  • 74.06 (a)
SLC16A7 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13907 37
  • 39 (a)
Species with no ortholog for SLC16A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A7 Gene

ENSEMBL:
Gene Tree for SLC16A7 (if available)
TreeFam:
Gene Tree for SLC16A7 (if available)

Paralogs for SLC16A7 Gene

genes like me logo Genes that share paralogs with SLC16A7: view

Variants for SLC16A7 Gene

Sequence variations from dbSNP and Humsavar for SLC16A7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3763980 - 59,779,575(-) TCTGG(A/T)CTTCT nc-transcript-variant, reference, missense
rs2047386 -- 59,639,294(-) ATATC(A/G)TAGTT intron-variant
rs7133415 -- 59,734,672(+) CACTT(C/G)AGGCA intron-variant
rs7134125 -- 59,594,933(+) GTATA(G/T)TATTT upstream-variant-2KB
rs2091771 -- 59,741,179(-) gtcat(C/T)ggtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A7 Gene

Variant ID Type Subtype PubMed ID
nsv899131 CNV Loss 21882294
nsv899132 CNV Loss 21882294
esv270362 CNV Insertion 20981092
dgv295e199 CNV Deletion 23128226
esv23936 CNV Loss 19812545
esv271056 CNV Insertion 20981092
esv273500 CNV Insertion 20981092
nsv899133 CNV Loss 21882294
nsv899134 CNV Loss 21882294
nsv899135 CNV Loss 21882294
esv275119 CNV Loss 21479260

Variation tolerance for SLC16A7 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A7 Gene

Human Gene Mutation Database (HGMD)
SLC16A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A7 Gene

Disorders for SLC16A7 Gene

Relevant External Links for SLC16A7

Genetic Association Database (GAD)
SLC16A7
Human Genome Epidemiology (HuGE) Navigator
SLC16A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A7

No disorders were found for SLC16A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A7 Gene

Publications for SLC16A7 Gene

  1. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. (PMID: 9786900) Lin R.-Y. … Golde D.W. (J. Biol. Chem. 1998) 2 3 4 23 25 26 67
  2. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PMID: 16604139) Bonen A. … Hatta H. (Appl Physiol Nutr Metab 2006) 23 25 26
  3. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. (PMID: 15953344) Pierre K. … Pellerin L. (J. Neurochem. 2005) 23 25 26
  4. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PMID: 19876643) PAcrez de Heredia F. … Trayhurn P. (Pflugers Arch. 2010) 3 23
  5. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PMID: 20454640) Pinheiro C. … Baltazar F. (J. Biomed. Biotechnol. 2010) 3 23

Products for SLC16A7 Gene

Sources for SLC16A7 Gene

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