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SLC16A7 Gene

protein-coding   GIFtS: 62
GCID: GC12P059989

Solute Carrier Family 16 (Monocarboxylate Transporter),...

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
  See SLC16A7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 16 (Monocarboxylate Transporter), Member 71 2     Solute Carrier Family 16, Member 7 (Monocarboxylic Acid Transporter 2)2
MCT22 3 5     MCT 23
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 71     Solute Carrier Family 16 Member 73
Monocarboxylate Transporter 22     

External Ids:    HGNC: 109281   Entrez Gene: 91942   Ensembl: ENSG000001185967   OMIM: 6036545   UniProtKB: O606693   

Export aliases for SLC16A7 gene to outside databases

Previous GC identifers: GC12P059779 GC12P060132 GC12P058276 GC12P058369 GC12P057131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC16A7 Gene:
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites,
such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked
transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be
more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jul 2012)

GeneCards Summary for SLC16A7 Gene:
SLC16A7 (solute carrier family 16 (monocarboxylate transporter), member 7) is a protein-coding gene. Diseases associated with SLC16A7 include colorectal cancer. GO annotations related to this gene include pyruvate secondary active transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC16A4.

UniProtKB/Swiss-Prot: MOT2_HUMAN, O60669
Function: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity
pyruvate transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC16A7 gene promoter:
         HOXA9B   HOXA9   HNF-3beta   Meis-1b   POU2F1   POU2F1a   Cart-1   FOXO1a   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC16A7 promoter sequence
   Search Chromatin IP Primers for SLC16A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC16A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14.1

SLC16A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P059989:  view genomic region     (about GC identifiers)

Start:
59,989,848 bp from pter      End:
60,176,395 bp from pter
Size:
186,548 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOT2_HUMAN, O60669 (See protein sequence)
Recommended Name: Monocarboxylate transporter 2  
Size: 478 amino acids; 52200 Da
Subunit: Interacts with GRID2IP (By similarity)
Secondary accessions: Q8NEM3 Q9UPB3

Explore the universe of human proteins at neXtProt for SLC16A7: NX_O60669

Explore proteomics data for SLC16A7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC16A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257551.1  NP_001257552.1  NP_004722.2  

    ENSEMBL proteins: 
     ENSP00000449547   ENSP00000448071   ENSP00000447555   ENSP00000448742   ENSP00000446722  
     ENSP00000261187   ENSP00000450133   ENSP00000449229   ENSP00000447459   ENSP00000449972  
     ENSP00000449167   ENSP00000448870   ENSP00000447814   ENSP00000443731  
    Reactome Protein details: O60669

    SLC16A7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 2
    SLC16 family of monocarboxylate transporters

    5 InterPro protein domains:
     IPR027178 MCT2
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR004743 Monocarb_transpt
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O60669

    ProtoNet protein and cluster: O60669

    UniProtKB/Swiss-Prot: MOT2_HUMAN, O60669
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    Find genes that share domains with SLC16A7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOT2_HUMAN, O60669
    Function: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
    many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
    isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity
    pyruvate transporter

         Genatlas biochemistry entry for SLC16A7:
    solute carrier family 16,member A7,monocarboxylic acids transporter,high affinity pyruvate transporter,restricted
    in normal tissues,widely expressed in cancer cell lines

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005477pyruvate secondary active transmembrane transporter activity TAS9786900
    GO:0015129lactate transmembrane transporter activity IDA9786900
    GO:0015293symporter activity IEA--
    GO:0015355secondary active monocarboxylate transmembrane transporter activity IEA--
    GO:0050833pyruvate transmembrane transporter activity IDA9786900
         
    Find genes that share ontologies with SLC16A7           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC16A7

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLC16A7 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOT2_HUMAN, O60669: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA15505343
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC16A7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC16A7 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Proton-coupled monocarboxylate transport0.00
    2Selected targets of HNF1
    Selected targets of HNF1
    3Selected targets of ESR1
    Selected targets of ESR1


    Find genes that share SuperPaths with SLC16A7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC16A7
        Proton-coupled monocarboxylate transport


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC16A7
    Interactions:

        Search GeneGlobe Interaction Network for SLC16A7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SLC16A7 (O606693 ENSP000002611874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNTA1Q134243I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    CPEB1ENSP000004141874STRING: ENSP00000414187
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006848pyruvate transport ----
    GO:0015711organic anion transport ----
    GO:0035873lactate transmembrane transport IMP9786900
    GO:0055085transmembrane transport TAS--
    GO:1901475pyruvate transmembrane transport IDA9786900

    Find genes that share ontologies with SLC16A7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC16A7 (MOT2)

    1 HMDB Compound for SLC16A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    10 DrugBank Compounds for SLC16A7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16604139 16766717 17556391 16597615 15953344
    transportersubstrate inhibitor16604139 16766717 17556391 16597615 15953344 10417314 9786900
    Lactic Acid-- 50-21-5transportersubstrate inhibitor10417314 9786900
    6-Deoxyglucose-- --transporterinhibitor9786900
    Acetoacetic Acid-- 541-50-4transporterinhibitor10417314
    Alpha-ketoisovalerate2-Keto-3-methylbutyric acid (see all 9)759-05-7transporterinhibitor10417314
    D-Lactic Acid-- 10326-41-7transporterinhibitor9786900
    Gamma Hydroxybutyric Acid4-Hydroxy-butanoic acid (see all 9)591-81-1transporterinhibitor9786900
    Niflumic Acid2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid (see all 13)4394-00-7transporterinhibitor10417314
    Probenecid-- 57-66-9transporterinhibitor10417314
    Quercetin-- 117-39-5transporterinhibitor10417314

    5 Novoseek inferred chemical compound relationships for SLC16A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 70.5 18 19404741 (3), 15505343 (2), 17502341 (2), 10921872 (1) (see all 10)
    pyruvate 64.2 7 9786900 (2), 16604139 (1), 7829520 (1)
    rapamycin 26.1 4 17394554 (1), 18093179 (1)
    glucose 24.3 3 11272148 (1), 19393029 (1)
    glutamate 10.7 1 11926280 (1)



    Find genes that share compounds with SLC16A7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC16A7 gene (3 alternative transcripts): 
    NM_001270622.1  NM_001270623.1  NM_004731.4  

    Unigene Cluster for SLC16A7:

    Solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
    Hs.88156  [show with all ESTs]
    Unigene Representative Sequence: NR_073055
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552432 ENST00000547379 ENST00000549465 ENST00000552024 ENST00000548610
    ENST00000261187(uc001sqs.3 uc001sqt.3 uc001squ.3 uc009zqi.3 uc010ssi.2)
    ENST00000550062 ENST00000549588 ENST00000546459 ENST00000552405 ENST00000549033
    ENST00000551877 ENST00000547801 ENST00000549928 ENST00000549305 ENST00000548444
    ENST00000543448
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    Additional mRNA sequence: 

    AF049608.1 AF058056.1 AK301725.1 AK310281.1 AK313345.1 BC007463.1 BC030693.2 NR_073055.1 
    NR_073056.1 

    9 DOTS entries:

    DT.203003  DT.439636  DT.91749690  DT.305036  DT.91749689  DT.121107285  DT.40279746  DT.97792992 
    DT.100684814 

    Selected AceView cDNA sequences (see all 28):

    BC030693 NM_004731 AI796731 CD678732 AI302205 AI473884 AF058056 CF891525 
    CF887757 CB241451 N42889 AI823653 BC007463 F01173 AL600173 BX112287 
    AL597759 BG401357 AI308108 AF049608 AI760494 BG721447 N34486 AA731520 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC16A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACACAGAGT
    SLC16A7 Expression
    About this image


    SLC16A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Kidney (Urinary System)
             Renal Collecting Duct System
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
    SLC16A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC16A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88156

    UniProtKB/Swiss-Prot: MOT2_HUMAN, O60669
    Tissue specificity: Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression
    in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted
    expression in normal tissues, but widely expressed in cancer cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC16A7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc16a71 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 77.44(n)1
    74.62(a)1
      10 (72.31 cM)5
    205031  NM_011391.11  NP_035521.11 
     1252274855 
    chicken
    (Gallus gallus)
    Aves SLC16A71 solute carrier family 16, member 7 (monocarboxylic more 72.96(n)
    73.97(a)
      417815  NM_001199604.1  NP_001186533.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC16A76
    solute carrier family 16 (monocarboxylate transpor...
    73(a)
    1 ↔ 1
    5(52079450-52201518)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc16a71 solute carrier family 16 (monocarboxylate transporter), more 69.58(n)
    72.65(a)
      100127205  NM_001112921.1  NP_001106392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1655071 zgc:165507 66.93(n)
    74.06(a)
      561188  NM_001099419.1  NP_001092889.1 


    ENSEMBL Gene Tree for SLC16A7 (if available)
    TreeFam Gene Tree for SLC16A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC16A7 gene
    SLC16A42  SLC16A32  SLC16A52  SLC16A112  SLC16A62  SLC16A82  SLC16A142  SLC16A12  
    SLC16A122  SLC16A92  SLC16A132  
    13 SIMAP similar genes for SLC16A7 using alignment to 10 protein entries:     MOT2_HUMAN (see all proteins):
    SLC16A1    SLC16A8    SLC16A3    SLC16A6    SLC16A13    SLC16A5
    SLC16A11    SLC16A12    SLC16A9    SLC16A4    SLC16A14    SLC16A2
    SLC16A10

    Find genes that share paralogs with SLC16A7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC16A7 (see all 3750)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1858794141,2
    --59987873(+) TGAATA/GTAAAT 2 -- us2k10--------
    rs73153081,2
    C,F,A--59987874(+) GAATAC/G/TAAATC 2 -- us2k17NA CSA WA EA 365
    rs1446651471,2
    --59987953(+) TTTTTA/CTCAAT 2 -- us2k10--------
    rs1906800881,2
    --59987985(+) AAGTCA/CTAGGA 2 -- us2k10--------
    rs1486990711,2
    --59988073(+) ATACCC/TAGCTA 2 -- us2k10--------
    rs1828534981,2
    --59988077(+) CTAGCC/TATCAC 2 -- us2k10--------
    rs1422287361,2
    C--59988116(+) AATACG/TAACTC 2 -- us2k10--------
    rs673762931,2
    C--59988179(+) AAAAGAAG/-GTTAC 2 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1462640551,2
    --59988225(+) ATTCAC/GCAATA 2 -- us2k10--------
    rs1167610161,2
    C,F--59988294(+) AAGAGA/CAGGAA 2 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for SLC16A7 (59989848 - 60176395 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC16A7 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv295e199CNV Deletion23128226
    esv273500CNV Insertion20981092
    esv270362CNV Insertion20981092
    esv271056CNV Insertion20981092
    nsv899135CNV Loss21882294
    nsv899134CNV Loss21882294
    esv275119CNV Loss21479260
    nsv899131CNV Loss21882294
    nsv899133CNV Loss21882294
    esv23936CNV Loss19812545

    Human Gene Mutation Database (HGMD): SLC16A7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC16A7
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603654    OMIM disorders: --

    1 disease for SLC16A7:    
    About MalaCards
    colorectal cancer


    Find genes that share disorders with SLC16A7           About GenesLikeMe

    Genetic Association Database (GAD): SLC16A7
    Human Genome Epidemiology (HuGE) Navigator: SLC16A7 (2 documents)

    Export disorders for SLC16A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC16A7 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with SLC16A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. (PubMed id 9786900)1, 2, 3, 7, 9 Lin R.-Y.... Golde D.W. (J. Biol. Chem. 1998)
    2. Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. (PubMed id 15505343)1, 2, 9 Merezhinskaya N....Fishbein W.N. (J. Histochem. Cytochem. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    5. Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study. (PubMed id 18598673)1, 9 Chiry O....Pellerin L. (Brain Res. 2008)
    6. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PubMed id 17502341)1, 9 Wang Q. and Morris M.E. (Drug Metab. Dispos. 2007)
    7. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PubMed id 19876643)1, 9 PAcrez de Heredia F....Trayhurn P. (Pflugers Arch. 2010)
    8. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PubMed id 16604139)7, 9 Bonen A....Hatta H. (Appl Physiol Nutr Metab 2006)
    9. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. (PubMed id 15953344)7, 9 Pierre K. and Pellerin L. (J. Neurochem. 2005)
    10. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. (PubMed id 18188595)1, 9 Pinheiro C....Baltazar F. (Virchows Arch. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9194 HGNC: 10928 AceView: SLC16A7 Ensembl:ENSG00000118596 euGenes: HUgn9194
    ECgene: SLC16A7 H-InvDB: SLC16A7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC16A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC16A7 gene:
    Search GeneIP for patents involving SLC16A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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