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Aliases for SLC16A7 Gene

Aliases for SLC16A7 Gene

  • Solute Carrier Family 16 Member 7 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 7 2 3
  • MCT2 3 4
  • Solute Carrier Family 16, Member 7 (Monocarboxylic Acid Transporter 2) 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 7 2
  • Monocarboxylate Transporter 2 3
  • MCT 2 4

External Ids for SLC16A7 Gene

Previous GeneCards Identifiers for SLC16A7 Gene

  • GC12P059779
  • GC12P060132
  • GC12P058276
  • GC12P058369
  • GC12P057131
  • GC12P059989

Summaries for SLC16A7 Gene

Entrez Gene Summary for SLC16A7 Gene

  • This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SLC16A7 Gene

SLC16A7 (Solute Carrier Family 16 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A1.

UniProtKB/Swiss-Prot for SLC16A7 Gene

  • Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.

Tocris Summary for SLC16A7 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

Additional gene information for SLC16A7 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A7 Gene

Genomics for SLC16A7 Gene

Regulatory Elements for SLC16A7 Gene

Enhancers for SLC16A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H059736 1.2 Ensembl ENCODE dbSUPER 10.6 +141.5 141473 2 SMARCE1 PKNOX1 CEBPB DPF2 EP300 FOXA1 ZNF217 CTBP1 GATA3 JUND SLC16A7 LOC100996696 ENSG00000257146
GH12H059698 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +103.5 103483 2 HLF CEBPB CEBPG EP300 RAD21 MAFF ATF3 FOS MAFK LOC100996696 SLC16A7 ENSG00000257146 GC12P059617
GH12H059650 0.7 Ensembl ENCODE 11.8 +55.7 55697 1 SOX13 CTCF GATA3 SLC16A7 RNU4-20P GC12P059617 ENSG00000257146
GH12H059663 0.5 dbSUPER 16.1 +71.7 71701 8 ZNF585B HNF4A ZBTB7B SLC16A7 RNU4-20P GC12P059617 ENSG00000257146
GH12H059723 0.7 dbSUPER 10.8 +129.1 129113 4 SOX13 GATAD2A FOXA2 FOXA3 CEBPG REST RAD21 FOXA1 JUND ATF3 SLC16A7 LOC100996696 ENSG00000257146
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A7 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052877 366 2201 SIN3A DMAP1 YY1 ETS1 GLIS2 ATF7 RUNX3 ZNF202 SP3 REST

Genomic Location for SLC16A7 Gene

Chromosome:
12
Start:
59,595,934 bp from pter
End:
59,789,855 bp from pter
Size:
193,922 bases
Orientation:
Plus strand

Genomic View for SLC16A7 Gene

Genes around SLC16A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A7 Gene

Proteins for SLC16A7 Gene

  • Protein details for SLC16A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60669-MOT2_HUMAN
    Recommended name:
    Monocarboxylate transporter 2
    Protein Accession:
    O60669
    Secondary Accessions:
    • Q8NEM3
    • Q9UPB3

    Protein attributes for SLC16A7 Gene

    Size:
    478 amino acids
    Molecular mass:
    52200 Da
    Quaternary structure:
    • Interacts with GRID2IP.

neXtProt entry for SLC16A7 Gene

Post-translational modifications for SLC16A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A7 Gene

Domains & Families for SLC16A7 Gene

Gene Families for SLC16A7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60669

UniProtKB/Swiss-Prot:

MOT2_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A7: view

Function for SLC16A7 Gene

Molecular function for SLC16A7 Gene

GENATLAS Biochemistry:
solute carrier family 16,member A7,monocarboxylic acids transporter,high affinity pyruvate transporter,restricted in normal tissues,widely expressed in cancer cell lines
UniProtKB/Swiss-Prot Function:
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.

Phenotypes From GWAS Catalog for SLC16A7 Gene

Gene Ontology (GO) - Molecular Function for SLC16A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005477 pyruvate secondary active transmembrane transporter activity TAS 9786900
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS,IEA --
GO:0015129 lactate transmembrane transporter activity IDA 9786900
GO:0015293 symporter activity IEA --
GO:0050833 pyruvate transmembrane transporter activity IDA 9786900
genes like me logo Genes that share ontologies with SLC16A7: view
genes like me logo Genes that share phenotypes with SLC16A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A7

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A7 Gene

Localization for SLC16A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A7 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
extracellular 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IDA 15505343
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A7: view

Pathways & Interactions for SLC16A7 Gene

genes like me logo Genes that share pathways with SLC16A7: view

Interacting Proteins for SLC16A7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261187%0d%0a9606.ENSP00000302289%0d%0a
Selected Interacting proteins: ENSP00000261187 O60669-MOT2_HUMAN for SLC16A7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC16A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport IEA --
GO:0035873 lactate transmembrane transport IMP 9786900
GO:0055085 transmembrane transport IEA --
GO:1901475 pyruvate transmembrane transport IEA,IDA 9786900
genes like me logo Genes that share ontologies with SLC16A7: view

No data available for SIGNOR curated interactions for SLC16A7 Gene

Drugs & Compounds for SLC16A7 Gene

(16) Drugs for SLC16A7 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gamma Hydroxybutyric Acid Approved, Illicit Pharma Transporter, inhibitor 0
Niflumic Acid Approved Pharma Channel blocker, Transporter, inhibitor Ca2+-activated Cl- channel blocker 0
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 30
Pyruvic acid Approved, Investigational Nutra Target, Transporter, substrate, inhibitor 0
Lactic Acid Approved, Vet_approved Pharma Transporter, substrate, inhibitor 0

(3) Additional Compounds for SLC16A7 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 13800
227321-12-2

(3) Tocris Compounds for SLC16A7 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1

(2) ApexBio Compounds for SLC16A7 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor 496791-37-8
UK-5099 MCTs and MPC inhibitor 56396-35-1
genes like me logo Genes that share compounds with SLC16A7: view

Drug Products

Transcripts for SLC16A7 Gene

Unigene Clusters for SLC16A7 Gene

Solute carrier family 16, member 7 (monocarboxylic acid transporter 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A7 Gene

No ASD Table

Relevant External Links for SLC16A7 Gene

GeneLoc Exon Structure for
SLC16A7
ECgene alternative splicing isoforms for
SLC16A7

Expression for SLC16A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A7 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7).

Protein differential expression in normal tissues from HIPED for SLC16A7 Gene

This gene is overexpressed in Pancreas (13.2), Frontal cortex (11.3), Heart (8.7), Kidney (7.3), and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC16A7 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC16A7 Gene:

SLC16A7

SOURCE GeneReport for Unigene cluster for SLC16A7 Gene:

Hs.88156

mRNA Expression by UniProt/SwissProt for SLC16A7 Gene:

O60669-MOT2_HUMAN
Tissue specificity: Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.

Evidence on tissue expression from TISSUES for SLC16A7 Gene

  • Liver(4.3)
  • Heart(2.3)
  • Muscle(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SLC16A7: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A7 Gene

Orthologs for SLC16A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A7 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia SLC16A7 33 34
  • 83.82 (n)
cow
(Bos Taurus)
Mammalia SLC16A7 33 34
  • 82.2 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a7 33
  • 77.51 (n)
mouse
(Mus musculus)
Mammalia Slc16a7 33 16 34
  • 77.44 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A7 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A7 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A7 33 34
  • 72.96 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A7 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a7 33
  • 69.58 (n)
zebrafish
(Danio rerio)
Actinopterygii SLC16A7 34
  • 67 (a)
OneToOne
zgc:165507 33
  • 66.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13907 35
  • 39 (a)
Species where no ortholog for SLC16A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A7 Gene

ENSEMBL:
Gene Tree for SLC16A7 (if available)
TreeFam:
Gene Tree for SLC16A7 (if available)

Paralogs for SLC16A7 Gene

Variants for SLC16A7 Gene

Sequence variations from dbSNP and Humsavar for SLC16A7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000004014 -- 59,774,447(+) GAATT(A/G)AACTT intron-variant
rs1000047756 -- 59,739,178(+) CCTAA(A/T)GCTAT intron-variant
rs1000048362 -- 59,697,774(+) TGGTT(C/T)ATTTC intron-variant
rs1000053169 -- 59,767,116(+) ATTAG(C/T)GAGAT intron-variant
rs1000062088 -- 59,752,932(+) CAGAA(G/T)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A7 Gene

Variant ID Type Subtype PubMed ID
dgv295e199 CNV deletion 23128226
esv23936 CNV loss 19812545
esv2670981 CNV deletion 23128226
esv275119 CNV loss 21479260
esv2762982 CNV gain 21179565
esv3306085 CNV mobile element insertion 20981092
esv3306780 CNV mobile element insertion 20981092
esv3309227 CNV mobile element insertion 20981092
esv3354729 CNV insertion 20981092
esv3380560 CNV insertion 20981092
esv3409549 CNV insertion 20981092
esv3446144 CNV insertion 20981092
esv3549273 CNV deletion 23714750
esv3580288 CNV loss 25503493
esv3629653 CNV gain 21293372
esv3629661 CNV gain 21293372
esv3629664 CNV loss 21293372
esv3629666 CNV loss 21293372
nsv1038100 CNV loss 25217958
nsv1048949 CNV gain 25217958
nsv1120263 CNV tandem duplication 24896259
nsv559050 CNV gain 21841781
nsv559101 CNV loss 21841781
nsv559102 CNV loss 21841781
nsv957254 CNV deletion 24416366

Variation tolerance for SLC16A7 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A7 Gene

Human Gene Mutation Database (HGMD)
SLC16A7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A7 Gene

Disorders for SLC16A7 Gene

Relevant External Links for SLC16A7

Genetic Association Database (GAD)
SLC16A7
Human Genome Epidemiology (HuGE) Navigator
SLC16A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A7

No disorders were found for SLC16A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A7 Gene

Publications for SLC16A7 Gene

  1. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. (PMID: 9786900) Lin RY … Golde DW (The Journal of biological chemistry 1998) 2 3 4 22 25 60
  2. Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. (PMID: 15505343) Merezhinskaya N … Fishbein WN (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004) 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PMID: 19876643) Pérez de Heredia F … Trayhurn P (Pflugers Archiv : European journal of physiology 2010) 3 22 60
  5. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PMID: 20454640) Pinheiro C … Baltazar F (Journal of biomedicine & biotechnology 2010) 3 22 60

Products for SLC16A7 Gene

Sources for SLC16A7 Gene

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