SLC16A7 Gene

Aliases
for SLC16A7 gene

Previous GC identifers: GC12P059779 GC12P060132 GC12P058276 GC12P058369 GC12P057131

Summaries
for SLC16A7 gene

Genomic Views
for SLC16A7 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmid: SLC16A7 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A7

SLC16A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P059989:  view genomic region     (about GC identifiers)

Proteins
for SLC16A7 gene

Explore the universe of human proteins at neXtProt for SLC16A7: NX_O60669

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLC16A7 OriGene Custom Protein Services for SLC16A7
	GenScript Custom Purified and Recombinant Proteins Services for SLC16A7
	Novus Biologicals SLC16A7 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC16A7

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC16A7
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	OriGene Antibodies: SLC16A7 OriGene Custom Antibody Services for SLC16A7
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	Novus Biologicals SLC16A7 Antibodies
	Search for Antibodies for SLC16A7 at Abcam
	Uscn Antibodies for SLC16A7
	ThermoFisher Antibodies for SLC16A7

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC16A7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC16A7

Protein Domains /
Families
for SLC16A7 gene

ProtoNet protein and cluster: O60669

Function
for SLC16A7 gene

miRNA Products:		OriGene 3'-UTR Clone: SLC16A7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC16A7
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC16A7:
		hsa-miR-3664-5p hsa-miR-1271 hsa-miR-605 hsa-miR-200a hsa-miR-7 hsa-miR-141 hsa-miR-489 hsa-miR-96
		SwitchGear 3'UTR luciferase reporter plasmid: SLC16A7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC16A7 (see all 7) OriGene shRNA RFP: SLC16A7 OriGene siRNA: SLC16A7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A7

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLC16A7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A7 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLC16A7 (NM_004731)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC16A7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC16A7
		Search LifeMap BioReagents cell lines for SLC16A7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A7

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for SLC16A7 gene

	Super-pathway	contained gene-specific pathways
1	SLC-mediated transmembrane transport	SLC-mediated transmembrane transport 1.00 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.38 Transmembrane transport of small molecules 0.50
2	Bile salt and organic anion SLC transporters	Bile salt and organic anion SLC transporters 1.00 Proton-coupled monocarboxylate transport 0.33
3	Selected targets of HNF1	Selected targets of HNF1 1.00
4	Selected targets of ESR1	Selected targets of ESR1 1.00

2 EMD Millipore Pathways for SLC16A7

	Selected targets of ESR1
	Selected targets of HNF1

5        Reactome Pathways for SLC16A7

	Bile salt and organic anion SLC transporters
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Proton-coupled monocarboxylate transport

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SLC16A7 gene

Transcripts
for SLC16A7 gene

Expression
for SLC16A7 gene

SLC16A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACACAGAGT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneMandibular Process			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC16A7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC16A7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC16A7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A7

Orthologs
for SLC16A7 gene

Paralogs
for SLC16A7 gene

Paralogs for SLC16A7 gene

SLC16A4²  SLC16A3²  SLC16A5²  SLC16A10²  SLC16A11²  SLC16A2²  SLC16A6²  SLC16A8²  

SLC16A14²  SLC16A1²  SLC16A12²  SLC16A9²  SLC16A13²  

13 SIMAP similar genes for SLC16A7 using alignment to 10 protein entries:     MOT2_HUMAN (see all proteins):

SLC16A1    SLC16A8    SLC16A3    SLC16A6    SLC16A13    SLC16A5

SLC16A11    SLC16A12    SLC16A9    SLC16A4    SLC16A14    SLC16A2

SLC16A10

SLC16A7 for paralogs           About GeneDecksing

Genomic Variants
for SLC16A7 gene

10/3150 NCBI SNPs in SLC16A7 are shown (see all 3150)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1858794141,2		--	59987873(+)	TGAATA/GTAAAT	2	--	us2k1		0	--	--	--	--
rs73153081,2	C,F,A,	--	59987874(+)	GAATAT/GAAATC	2	--	us2k1		7		NA CSA WA EA	365
rs1446651471,2		--	59987953(+)	TTTTTA/CTCAAT	2	--	us2k1		0	--	--	--	--
rs1906800881,2		--	59987985(+)	AAGTCA/CTAGGA	2	--	us2k1		0	--	--	--	--
rs1486990711,2		--	59988073(+)	ATACCC/TAGCTA	2	--	us2k1		0	--	--	--	--
rs1828534981,2		--	59988077(+)	CTAGCC/TATCAC	2	--	us2k1		0	--	--	--	--
rs1422287361,2		--	59988116(+)	AATACG/TAACTC	2	--	us2k1		0	--	--	--	--
rs673762931,2	C,	--	59988179(+)	AAAAGAAG/-GTTAC	2	--	us2k1		1		NA	2
rs1462640551,2		--	59988225(+)	ATTCAC/GCAATA	2	--	us2k1		0	--	--	--	--
rs1167610161,2	C,F,	--	59988294(+)	AAGAGA/CAGGAA	2	--	us2k1		1		WA	118

HapMap Linkage Disequilibrium report for SLC16A7 (59989848 - 60176395 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC16A7
     2 CNVs: 86416 66240

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC16A7

DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A7

Disorders / Diseases
for SLC16A7 gene

Publications
for SLC16A7 gene

PubMed articles for SLC16A7 gene, integrated from 9 sources (see all 56): (articles sorted by number of sources associating them with SLC16A7)

Utopia: connect your pdf to the dynamic world of online information

1. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. (PubMed id 9786900)^{1, 2, 3, 7, 9} Lin R.-Y.... Golde D.W. (1998)
2. Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study. (PubMed id 18598673)^{1, 9} Chiry O....Pellerin L. (2008)
3. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PubMed id 17502341)^{1, 9} Wang Q. and Morris M.E. (2007)
4. Hypoxia stimulates lactate release and modulates mono carboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PubMed id 19876643)^{1, 9} PAcrez de Heredia F....Trayhurn P. (2010)
5. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PubMed id 16604139)^{7, 9} Bonen A....Hatta H. (2006)
6. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. (PubMed id 15953344)^{7, 9} Pierre K. and Pellerin L. (2005)
7. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. (PubMed id 18188595)^{1, 9} Pinheiro C....Baltazar F. (2008)
8. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PubMed id 20454640)^{1, 9} Pinheiro C....Baltazar F. (2010)
9. The monocarboxylate transporter family--Structure and functional characterization. (PubMed id 22131303)¹ Halestrap A.P. (2012)
10. Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. (PubMed id 22535546)¹ Lauritzen F....Bergersen L.H. (2012)

External Searches for SLC16A7 gene

Genome Databases showing SLC16A7 gene

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Specialized Databases showing SLC16A7 gene

Products
for SLC16A7 gene