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Aliases for SLC16A6 Gene

Aliases for SLC16A6 Gene

  • Solute Carrier Family 16, Member 6 2 3
  • Solute Carrier Family 16, Member 6 (Monocarboxylic Acid Transporter 7) 2 3
  • Monocarboxylate Transporter 6 3 4
  • MCT7 3 4
  • MCT6 3 4
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 6 2
  • Solute Carrier Family 16 Member 6 4
  • Monocarboxylate Transporter 7 3
  • Breast Cancer Protein BCY5 3
  • MCT 7 4
  • MCT 6 4

External Ids for SLC16A6 Gene

Summaries for SLC16A6 Gene

GeneCards Summary for SLC16A6 Gene

SLC16A6 (Solute Carrier Family 16, Member 6) is a Protein Coding gene. Diseases associated with SLC16A6 include breast cancer. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A6 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A6 Gene

Genomics for SLC16A6 Gene

Genomic Location for SLC16A6 Gene

Start:
68,267,026 bp from pter
End:
68,291,267 bp from pter
Size:
24,242 bases
Orientation:
Minus strand

Genomic View for SLC16A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC16A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A6 Gene

Regulatory Elements for SLC16A6 Gene

Proteins for SLC16A6 Gene

  • Protein details for SLC16A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15403-MOT7_HUMAN
    Recommended name:
    Monocarboxylate transporter 7
    Protein Accession:
    O15403
    Secondary Accessions:
    • Q6P1X3

    Protein attributes for SLC16A6 Gene

    Size:
    523 amino acids
    Molecular mass:
    57393 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC52014.1; Type=Frameshift; Positions=401, 416; Evidence={ECO:0000305};

neXtProt entry for SLC16A6 Gene

Proteomics data for SLC16A6 Gene at MOPED

Post-translational modifications for SLC16A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A6 Gene

No data available for DME Specific Peptides for SLC16A6 Gene

Domains for SLC16A6 Gene

Gene Families for SLC16A6 Gene

Protein Domains for SLC16A6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MOT7_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.:
    • O15403
genes like me logo Genes that share domains with SLC16A6: view

Function for SLC16A6 Gene

Molecular function for SLC16A6 Gene

UniProtKB/Swiss-Prot Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A6: view

miRNA for SLC16A6 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC16A6 Gene

Localization for SLC16A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A6 Gene COMPARTMENTS Subcellular localization image for SLC16A6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9425115
GO:0016020 membrane TAS 9425115
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC16A6: view

Pathways for SLC16A6 Gene

SuperPathways for SLC16A6 Gene

No Data Available

Interacting Proteins for SLC16A6 Gene

Gene Ontology (GO) - Biological Process for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015718 monocarboxylic acid transport TAS 9425115
GO:0034220 ion transmembrane transport IBA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC16A6: view

No data available for Pathways by source for SLC16A6 Gene

Compounds for SLC16A6 Gene

(1) HMDB Compounds for SLC16A6 Gene

Compound Synonyms Cas Number PubMed IDs
Pyruvic acid
  • 2-Oxopropanoate
127-17-3

(1) Drugbank Compounds for SLC16A6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyruvic acid
  • 2-Oxopropanoate
127-17-3 target
genes like me logo Genes that share compounds with SLC16A6: view

Transcripts for SLC16A6 Gene

Unigene Clusters for SLC16A6 Gene

Solute carrier family 16, member 6 (monocarboxylic acid transporter 7):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5:

Relevant External Links for SLC16A6 Gene

GeneLoc Exon Structure for
SLC16A6
ECgene alternative splicing isoforms for
SLC16A6

Expression for SLC16A6 Gene

mRNA expression in normal human tissues for SLC16A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A6 Gene

This gene is overexpressed in Whole Blood (9.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC16A6 Gene

SOURCE GeneReport for Unigene cluster for SLC16A6 Gene Hs.42645

genes like me logo Genes that share expressions with SLC16A6: view

Orthologs for SLC16A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC16A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
SLC16A6 36
  • 99.3 (n)
  • 99.24 (a)
SLC16A6 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SLC16A6 36
  • 75.36 (n)
  • 79.18 (a)
SLC16A6 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A6 36
  • 84.7 (n)
  • 86.04 (a)
SLC16A6 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a6 36
  • 81.93 (n)
  • 84.87 (a)
Slc16a6 16
Slc16a6 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A6 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A6 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a6 36
  • 79.37 (n)
  • 82.18 (a)
chicken
(Gallus gallus)
Aves SLC16A6 36
  • 72.1 (n)
  • 70.53 (a)
SLC16A6 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A6 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia slc16a6-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a6 36
  • 65.8 (n)
  • 68.07 (a)
Str.13982 36
zebrafish
(Danio rerio)
Actinopterygii slc16a6a 37
  • 54 (a)
OneToMany
slc16a6b 36
  • 59.75 (n)
  • 56.78 (a)
slc16a6b 37
  • 55 (a)
OneToMany
wufb51h06 36
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCH2 39
bread mold
(Neurospora crassa)
Ascomycetes NCU09550 36
  • 40.29 (n)
  • 28.88 (a)
Species with no ortholog for SLC16A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A6 Gene

ENSEMBL:
Gene Tree for SLC16A6 (if available)
TreeFam:
Gene Tree for SLC16A6 (if available)

Paralogs for SLC16A6 Gene

Selected SIMAP similar genes for SLC16A6 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SLC16A6 Gene

genes like me logo Genes that share paralogs with SLC16A6: view

Variants for SLC16A6 Gene

Sequence variations from dbSNP and Humsavar for SLC16A6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_053656 -
VAR_053657 -
VAR_053658 -
VAR_053659 -

Structural Variations from Database of Genomic Variants (DGV) for SLC16A6 Gene

Variant ID Type Subtype PubMed ID
nsv908692 CNV Loss 21882294

Relevant External Links for SLC16A6 Gene

HapMap Linkage Disequilibrium report
SLC16A6

Disorders for SLC16A6 Gene

(1) MalaCards Diseases for SLC16A6 Gene

Search for SLC16A6 Gene in MalaCards »
genes like me logo Genes that share disorders with SLC16A6: view

No data available for UniProtKB/Swiss-Prot for SLC16A6 Gene

Publications for SLC16A6 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PMID: 16604139) Bonen A. … Hatta H. (Appl Physiol Nutr Metab 2006) 23 25
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for SLC16A6 Gene

  • antibodies-online peptides for SLC16A6
  • antibodies-online antibodies for SLC16A6
  • antibodies-online kits for SLC16A6

Sources for SLC16A6 Gene

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