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Aliases for SLC16A6 Gene

Aliases for SLC16A6 Gene

  • Solute Carrier Family 16 Member 6 2 3 4 5
  • Solute Carrier Family 16, Member 6 (Monocarboxylic Acid Transporter 7) 2 3
  • Monocarboxylate Transporter 6 3 4
  • MCT7 3 4
  • MCT6 3 4
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 6 2
  • Solute Carrier Family 16, Member 6 2
  • Monocarboxylate Transporter 7 3
  • Breast Cancer Protein BCY5 3
  • MCT 7 4
  • MCT 6 4

External Ids for SLC16A6 Gene

Previous GeneCards Identifiers for SLC16A6 Gene

  • GC17M066068
  • GC17M069224
  • GC17M066729
  • GC17M066861
  • GC17M063775
  • GC17M066264
  • GC17M061649

Summaries for SLC16A6 Gene

GeneCards Summary for SLC16A6 Gene

SLC16A6 (Solute Carrier Family 16 Member 6) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A13.

UniProtKB/Swiss-Prot for SLC16A6 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A6 Gene

Genomics for SLC16A6 Gene

Regulatory Elements for SLC16A6 Gene

Enhancers for SLC16A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G068287 1.8 FANTOM5 ENCODE dbSUPER 14 +0.9 911 6.2 HDGF PKNOX1 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NOL11 AMZ2 SLC16A6 PRKAR1A BPTF GC17P068267
GH17G068311 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -22.3 -22303 4.1 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 FOS ZNF263 SP5 ZHX2 MIR635 SLC16A6 ABCA6 PRKAR1A BPTF GC17M068333
GH17G068377 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -91.6 -91577 11.7 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 NOL11 ENSG00000267731 MIR635 LOC100418928 SLC16A6 AMZ2 WIPI1 GC17M068333 ENSG00000267009 PRKAR1A
GH17G068234 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +53.6 53612 7.3 PKNOX1 FOXA2 ATF1 WRNIP1 ARID4B YY1 ZNF143 ZNF207 FOS NFYC LOC440461 AMZ2 ARSG SLC16A6 BPTF GC17P068233 ENSG00000265100
GH17G067438 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +849.5 849490 6.4 PKNOX1 FOXA2 MLX ZFP64 SIN3A ARID4B ZNF48 ZNF121 FOS ZNF202 NOL11 HELZ LOC100418928 MIR548D2 MIR548AA2 PITPNC1 ENSG00000267731 SLC16A6 BPTF RN7SL756P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000097478 -33 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B FOS

Genomic Location for SLC16A6 Gene

Chromosome:
17
Start:
68,267,026 bp from pter
End:
68,291,267 bp from pter
Size:
24,242 bases
Orientation:
Minus strand

Genomic View for SLC16A6 Gene

Genes around SLC16A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A6 Gene

Proteins for SLC16A6 Gene

  • Protein details for SLC16A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15403-MOT7_HUMAN
    Recommended name:
    Monocarboxylate transporter 7
    Protein Accession:
    O15403
    Secondary Accessions:
    • Q6P1X3

    Protein attributes for SLC16A6 Gene

    Size:
    523 amino acids
    Molecular mass:
    57393 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC52014.1; Type=Frameshift; Positions=401, 416; Evidence={ECO:0000305};

neXtProt entry for SLC16A6 Gene

Post-translational modifications for SLC16A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A6 Gene

Domains & Families for SLC16A6 Gene

Gene Families for SLC16A6 Gene

Protein Domains for SLC16A6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A6 Gene

Graphical View of Domain Structure for InterPro Entry

O15403

UniProtKB/Swiss-Prot:

MOT7_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A6: view

Function for SLC16A6 Gene

Molecular function for SLC16A6 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS 9425115
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A6: view
genes like me logo Genes that share phenotypes with SLC16A6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A6

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A6 Gene

Localization for SLC16A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9425115
GO:0016020 membrane IEA,TAS 9425115
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A6: view

Pathways & Interactions for SLC16A6 Gene

SuperPathways for SLC16A6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport TAS 9425115
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A6: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A6 Gene

Drugs & Compounds for SLC16A6 Gene

(1) Drugs for SLC16A6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0
genes like me logo Genes that share compounds with SLC16A6: view

Transcripts for SLC16A6 Gene

Unigene Clusters for SLC16A6 Gene

Solute carrier family 16, member 6 (monocarboxylic acid transporter 7):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5:

Relevant External Links for SLC16A6 Gene

GeneLoc Exon Structure for
SLC16A6
ECgene alternative splicing isoforms for
SLC16A6

Expression for SLC16A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A6 Gene

This gene is overexpressed in Whole Blood (x9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A6 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC16A6 Gene:

SLC16A6

SOURCE GeneReport for Unigene cluster for SLC16A6 Gene:

Hs.42645

Evidence on tissue expression from TISSUES for SLC16A6 Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with SLC16A6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A6 Gene

Orthologs for SLC16A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC16A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A6 34 35
  • 99.3 (n)
-- 35
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC16A6 34 35
  • 84.7 (n)
mouse
(Mus musculus)
Mammalia Slc16a6 34 16 35
  • 81.93 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a6 34
  • 79.37 (n)
cow
(Bos Taurus)
Mammalia SLC16A6 34 35
  • 75.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A6 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A6 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A6 34 35
  • 72.1 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A6 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a6 34
  • 65.8 (n)
Str.13982 34
African clawed frog
(Xenopus laevis)
Amphibia slc16a6-prov 34
zebrafish
(Danio rerio)
Actinopterygii slc16a6b 34 35
  • 59.75 (n)
slc16a6a 35
  • 54 (a)
OneToMany
wufb51h06 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCH2 37
bread mold
(Neurospora crassa)
Ascomycetes NCU09550 34
  • 40.29 (n)
Species where no ortholog for SLC16A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A6 Gene

ENSEMBL:
Gene Tree for SLC16A6 (if available)
TreeFam:
Gene Tree for SLC16A6 (if available)

Paralogs for SLC16A6 Gene

(7) SIMAP similar genes for SLC16A6 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SLC16A6 Gene

genes like me logo Genes that share paralogs with SLC16A6: view

Variants for SLC16A6 Gene

Sequence variations from dbSNP and Humsavar for SLC16A6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000592033 -- 68,277,267(+) CTGGG(A/C)TTACA intron-variant
rs1000849561 -- 68,284,550(+) AAGGT(G/T)TTATT intron-variant
rs1000901843 -- 68,284,348(+) AAGAT(C/T)GTGCC intron-variant
rs1001014226 -- 68,290,675(+) AGGTA(C/G)CTCTG intron-variant, upstream-variant-2KB
rs1001233243 -- 68,285,562(+) CTACT(C/T)GGGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC16A6 Gene

Variant ID Type Subtype PubMed ID
nsv1116234 CNV deletion 24896259
nsv1126468 CNV deletion 24896259
nsv978460 CNV duplication 23825009

Variation tolerance for SLC16A6 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A6 Gene

Disorders for SLC16A6 Gene

Relevant External Links for SLC16A6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A6

No disorders were found for SLC16A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A6 Gene

Publications for SLC16A6 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PMID: 16604139) Bonen A. … Hatta H. (Appl Physiol Nutr Metab 2006) 22 25 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Gene expression analysis of a panel of cell lines that differentially restrict HIV-1 CA mutants infection in a cyclophilin a-dependent manner. (PMID: 24663101) Shah V.B. … Aiken C. (PLoS ONE 2014) 3 64

Products for SLC16A6 Gene

Sources for SLC16A6 Gene

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