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SLC16A6 Gene

protein-coding   GIFtS: 52
GCID: GC17M066264

Solute Carrier Family 16, Member 6

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 16, Member 61 2     Breast Cancer Protein BCY52
Solute Carrier Family 16, Member 6 (Monocarboxylic Acid Transporter 7)1 2     Monocarboxylate Transporter 72
Monocarboxylate Transporter 62 3     MCT 63
MCT62 3     MCT 73
MCT72 3     Solute Carrier Family 16 Member 63
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 61     

External Ids:    HGNC: 109271   Entrez Gene: 91202   Ensembl: ENSG000001089327   OMIM: 6038805   UniProtKB: O154033   

Export aliases for SLC16A6 gene to outside databases

Previous GC identifers: GC17M066068 GC17M069224 GC17M066729 GC17M066861 GC17M063775 GC17M061649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC16A6 Gene:
SLC16A6 (solute carrier family 16, member 6) is a protein-coding gene. Diseases associated with SLC16A6 include breast cancer. GO annotations related to this gene include monocarboxylic acid transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC16A4.

UniProtKB/Swiss-Prot: MOT7_HUMAN, O15403
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC16A6 gene promoter:
         NF-1   NF-1/L   Pax-2   Olf-1   Pax-2a   Egr-2   HSF2   FOXO1a   LyF-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC16A6 promoter sequence
   Search Chromatin IP Primers for SLC16A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC16A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.2

SLC16A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M066264:  view genomic region     (about GC identifiers)

Start:
66,263,167 bp from pter      End:
66,287,408 bp from pter
Size:
24,242 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MOT7_HUMAN, O15403 (See protein sequence)
Recommended Name: Monocarboxylate transporter 7  
Size: 523 amino acids; 57393 Da
Sequence caution: Sequence=AAC52014.1; Type=Frameshift; Positions=401, 416;
Secondary accessions: Q6P1X3

Explore the universe of human proteins at neXtProt for SLC16A6: NX_O15403

Explore proteomics data for SLC16A6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC16A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001167637.1  NP_004685.2  

    ENSEMBL proteins: 
     ENSP00000319991   ENSP00000462985   ENSP00000463070   ENSP00000462239  

    SLC16A6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SLC16A6

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    Cloud-Clone Corp. CLIAs for SLC16A6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 7
    SLC16 family of monocarboxylate transporters

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O15403

    ProtoNet protein and cluster: O15403

    UniProtKB/Swiss-Prot: MOT7_HUMAN, O15403
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    SLC16A6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOT7_HUMAN, O15403
    Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
    many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
    isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008028monocarboxylic acid transmembrane transporter activity TAS9425115
    GO:0015293symporter activity IEA--
         
    SLC16A6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC16A6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC16A6
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    miRNA
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    miRTarBase miRNAs that target SLC16A6:
    hsa-mir-192-5p (MIRT026327), hsa-mir-124-3p (MIRT022486), hsa-mir-215-5p (MIRT024746), hsa-mir-335-5p (MIRT017473)

    Block miRNA regulation of human, mouse, rat SLC16A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC16A6 (see all 97):
    hsa-miR-3678-3p hsa-miR-100* hsa-miR-520e hsa-miR-193a-3p hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOT7_HUMAN, O15403: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS9425115
    GO:0016020membrane TAS9425115
    GO:0016021integral component of membrane ----

    SLC16A6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC16A6 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of ESR1
    Selected targets of ESR1



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC16A6
    Interactions:

        GeneGlobe Interaction Network for SLC16A6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC16A6 (ENSP000003199914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015718monocarboxylic acid transport TAS9425115
    GO:0055085transmembrane transport ----

    SLC16A6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC16A6 (MOT7)

    1 HMDB Compound for SLC16A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    1 DrugBank Compound for SLC16A6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16604139



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC16A6 gene (2 alternative transcripts): 
    NM_001174166.1  NM_004694.4  

    Unigene Cluster for SLC16A6:

    Solute carrier family 16, member 6 (monocarboxylic acid transporter 7)
    Hs.42645  [show with all ESTs]
    Unigene Representative Sequence: NM_001174166
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327268(uc002jha.2 uc002jgz.2) ENST00000580666 ENST00000583477
    ENST00000582867
    miRNA
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    Block miRNA regulation of human, mouse, rat SLC16A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC16A6 (see all 97):
    hsa-miR-3678-3p hsa-miR-100* hsa-miR-520e hsa-miR-193a-3p hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A6 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): SLC16A6 (NM_004694)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A6
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC16A6
      QuantiFast Probe-based Assays in human, mouse, rat SLC16A6

    Additional mRNA sequence: 

    AK290417.1 AK313121.1 BC064832.1 BC127749.1 BC127750.1 BC141962.1 BC150547.1 BC150548.1 
    U79745.1 

    6 DOTS entries:

    DT.100676705  DT.100704538  DT.441846  DT.100680894  DT.95139838  DT.95100268 

    Selected AceView cDNA sequences (see all 55):

    AX750576 AI378755 AA182477 BM713971 BM673964 BM712975 NM_004694 AI566367 
    BM674613 BQ637648 BM725555 AL711877 AX750582 BC064832 BX390698 CD518844 
    AX750581 AV704433 H99207 N32536 AX750577 BX110425 AI767137 BV205073 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -     -                                             
    SP2:                                                                        
    SP3:                                -                                       
    SP4:                    -     -                 -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for SLC16A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC16A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGGCAAA
    SLC16A6 Expression
    About this image


    SLC16A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Kidney (Urinary System)
             Metanephros
    SLC16A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC16A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42645
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC16A6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc16a61 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 81.93(n)1
    84.87(a)1
      11 (71.94 cM)5
    1046811  NM_001029842.11  NP_001025013.11 
     1094508555 
    chicken
    (Gallus gallus)
    Aves SLC16A61 solute carrier family 16, member 6 (monocarboxylic more 72.1(n)
    70.53(a)
      417435  XM_415687.3  XP_415687.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC16A66
    solute carrier family 16, member 6
    68(a)
    1 ↔ 1
    GL343260.1(1472254-1479234)
    African clawed frog
    (Xenopus laevis)
    Amphibia slc16a6-prov2 solute carrier family 16 (monocarboxylic acid transporters), more 76.91(n)    BC047967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb51h062 Transcribed sequence with weak similarity to protein more 73.96(n)    57097160 


    ENSEMBL Gene Tree for SLC16A6 (if available)
    TreeFam Gene Tree for SLC16A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC16A6 gene
    SLC16A42  SLC16A32  SLC16A52  SLC16A112  SLC16A82  SLC16A142  SLC16A72  SLC16A12  
    SLC16A122  SLC16A92  SLC16A132  
    7 SIMAP similar genes for SLC16A6 using alignment to 5 protein entries:     MOT7_HUMAN (see all proteins):
    SLC16A7    SLC16A3    SLC16A8    SLC16A12    SLC16A1    SLC16A4
    SLC16A13

    SLC16A6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC16A6
    PGOHUM00000262991


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for SLC16A6    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72220131,2,4
    ----see VAR_0536572 mis40--------
    rs37443071,2,4
    ----see VAR_0536582 mis40--------
    rs44101411,2,4
    ----see VAR_0536592 mis40--------
    rs353978261,2,4
    ----see VAR_0536562 mis40--------

    HapMap Linkage Disequilibrium report for SLC16A6 (66263167 - 66287408 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC16A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908692CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC16A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603880    OMIM disorders: --

    1 disease for SLC16A6:    
    About MalaCards
    breast cancer


    SLC16A6 for disorders           About GeneDecksing


    Export disorders for SLC16A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC16A6 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SLC16A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PubMed id 9425115)1, 2, 3 Price N.T.... Halestrap A.P. (Biochem. J. 1998)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PubMed id 16604139)7, 9 Bonen A....Hatta H. (Appl Physiol Nutr Metab 2006)
    4. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). (PubMed id 16174808)1 Murakami Y....Yamamoto T. (Drug Metab. Dispos. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PubMed id 12739169)1 Halestrap A.P. and Meredith D. (Pflugers Arch. 2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9120 HGNC: 10927 AceView: SLC16A6 Ensembl:ENSG00000108932 euGenes: HUgn9120
    ECgene: SLC16A6 H-InvDB: SLC16A6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC16A6 Pharmacogenomics, SNPs, Pathways

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