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Aliases for SLC16A6 Gene

Aliases for SLC16A6 Gene

  • Solute Carrier Family 16 Member 6 2 3 4 5
  • Solute Carrier Family 16, Member 6 (Monocarboxylic Acid Transporter 7) 2 3
  • Monocarboxylate Transporter 6 3 4
  • MCT7 3 4
  • MCT6 3 4
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 6 2
  • Solute Carrier Family 16, Member 6 2
  • Breast Cancer Protein BCY5 3
  • MCT 7 4
  • MCT 6 4

External Ids for SLC16A6 Gene

Previous GeneCards Identifiers for SLC16A6 Gene

  • GC17M066068
  • GC17M069224
  • GC17M066729
  • GC17M066861
  • GC17M063775
  • GC17M066264
  • GC17M061649

Summaries for SLC16A6 Gene

GeneCards Summary for SLC16A6 Gene

SLC16A6 (Solute Carrier Family 16 Member 6) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A6 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A6 Gene

Genomics for SLC16A6 Gene

Regulatory Elements for SLC16A6 Gene

Enhancers for SLC16A6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC16A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC16A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC16A6 Gene

Chromosome:
17
Start:
68,267,026 bp from pter
End:
68,291,267 bp from pter
Size:
24,242 bases
Orientation:
Minus strand

Genomic View for SLC16A6 Gene

Genes around SLC16A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A6 Gene

Proteins for SLC16A6 Gene

  • Protein details for SLC16A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15403-MOT7_HUMAN
    Recommended name:
    Monocarboxylate transporter 7
    Protein Accession:
    O15403
    Secondary Accessions:
    • Q6P1X3

    Protein attributes for SLC16A6 Gene

    Size:
    523 amino acids
    Molecular mass:
    57393 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC52014.1; Type=Frameshift; Positions=401, 416; Evidence={ECO:0000305};

neXtProt entry for SLC16A6 Gene

Proteomics data for SLC16A6 Gene at MOPED

Post-translational modifications for SLC16A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A6 Gene

No data available for DME Specific Peptides for SLC16A6 Gene

Domains & Families for SLC16A6 Gene

Gene Families for SLC16A6 Gene

Protein Domains for SLC16A6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A6 Gene

Graphical View of Domain Structure for InterPro Entry

O15403

UniProtKB/Swiss-Prot:

MOT7_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A6: view

Function for SLC16A6 Gene

Molecular function for SLC16A6 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015129 lactate transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC16A6: view
genes like me logo Genes that share phenotypes with SLC16A6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A6

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A6 Gene

Localization for SLC16A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A6 Gene COMPARTMENTS Subcellular localization image for SLC16A6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9425115
genes like me logo Genes that share ontologies with SLC16A6: view

Pathways & Interactions for SLC16A6 Gene

SuperPathways for SLC16A6 Gene

No Data Available

Interacting Proteins for SLC16A6 Gene

Gene Ontology (GO) - Biological Process for SLC16A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A6: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A6 Gene

Drugs & Compounds for SLC16A6 Gene

(1) Drugs for SLC16A6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0
genes like me logo Genes that share compounds with SLC16A6: view

Transcripts for SLC16A6 Gene

Unigene Clusters for SLC16A6 Gene

Solute carrier family 16, member 6 (monocarboxylic acid transporter 7):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5:

Relevant External Links for SLC16A6 Gene

GeneLoc Exon Structure for
SLC16A6
ECgene alternative splicing isoforms for
SLC16A6

Expression for SLC16A6 Gene

mRNA expression in normal human tissues for SLC16A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A6 Gene

This gene is overexpressed in Whole Blood (x9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A6 Gene



SOURCE GeneReport for Unigene cluster for SLC16A6 Gene Hs.42645

genes like me logo Genes that share expression patterns with SLC16A6: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC16A6 Gene

Orthologs for SLC16A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC16A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC16A6 35
  • 75.36 (n)
  • 79.18 (a)
SLC16A6 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A6 35
  • 84.7 (n)
  • 86.04 (a)
SLC16A6 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a6 35
  • 81.93 (n)
  • 84.87 (a)
Slc16a6 16
Slc16a6 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC16A6 35
  • 99.3 (n)
  • 99.24 (a)
-- 36
  • 97 (a)
OneToMany
SLC16A6 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc16a6 35
  • 79.37 (n)
  • 82.18 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC16A6 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A6 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A6 35
  • 72.1 (n)
  • 70.53 (a)
SLC16A6 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A6 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a6 35
  • 65.8 (n)
  • 68.07 (a)
Str.13982 35
African clawed frog
(Xenopus laevis)
Amphibia slc16a6-prov 35
zebrafish
(Danio rerio)
Actinopterygii slc16a6b 35
  • 59.75 (n)
  • 56.78 (a)
wufb51h06 35
slc16a6a 36
  • 54 (a)
OneToMany
slc16a6b 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCH2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09550 35
  • 40.29 (n)
  • 28.88 (a)
Species with no ortholog for SLC16A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A6 Gene

ENSEMBL:
Gene Tree for SLC16A6 (if available)
TreeFam:
Gene Tree for SLC16A6 (if available)

Paralogs for SLC16A6 Gene

(7) SIMAP similar genes for SLC16A6 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SLC16A6 Gene

genes like me logo Genes that share paralogs with SLC16A6: view

Variants for SLC16A6 Gene

Sequence variations from dbSNP and Humsavar for SLC16A6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_053656 -
VAR_053657 -
VAR_053658 -
VAR_053659 -

Structural Variations from Database of Genomic Variants (DGV) for SLC16A6 Gene

Variant ID Type Subtype PubMed ID
nsv908692 CNV Loss 21882294

Variation tolerance for SLC16A6 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A6 Gene

HapMap Linkage Disequilibrium report
SLC16A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A6 Gene

Disorders for SLC16A6 Gene

Relevant External Links for SLC16A6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A6

No disorders were found for SLC16A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A6 Gene

Publications for SLC16A6 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 67
  2. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PMID: 16604139) Bonen A. … Hatta H. (Appl Physiol Nutr Metab 2006) 23 25 26
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Gene expression analysis of a panel of cell lines that differentially restrict HIV-1 CA mutants infection in a cyclophilin a-dependent manner. (PMID: 24663101) Shah V.B. … Aiken C. (PLoS ONE 2014) 3
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3

Products for SLC16A6 Gene

Sources for SLC16A6 Gene

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