Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC16A5 Gene

protein-coding   GIFtS: 49
GCID: GC17P073084

solute carrier family 16, member 5 (monocarboxylic acid...

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
  Search for SLC16A5
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC16A5    

Aliases
for SLC16A5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 16, Member 5 (Monocarboxylic Acid Transporter 6)1 2     Monocarboxylate Transporter 62
MCT51 2 3     MCT 53
MCT61 2 3     MCT 63
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 51 2     Solute Carrier Family 16 Member 53
Monocarboxylate Transporter 52 3     

External Ids:    HGNC: 109261   Entrez Gene: 91212   Ensembl: ENSG000001701907   OMIM: 6038795   UniProtKB: O153753   

Export aliases for SLC16A5 gene to outside databases

Previous GC identifers: GC17P073054 GC17P076143 GC17P073547 GC17P073680 GC17P073681 GC17P070595 GC17P068493


Summaries
for SLC16A5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC16A5:
This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded
protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the
encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: MOT6_HUMAN, O15375
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many
monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and
the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)




Genomic Views
for SLC16A5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC16A5 gene promoter:
         c-Fos   AP-1   Egr-1   NRSF form 1   Lmo2   NRSF form 2   E47   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC16A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC16A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

SLC16A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073084:  view genomic region     (about GC identifiers)

Start:
 73,083,822 bp from pter      End:
 73,102,257 bp from pter
Size:
 18,436 bases      Orientation:
 plus strand

Proteins
for SLC16A5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MOT6_HUMAN, O15375 (See protein sequence)
Recommended Name: Monocarboxylate transporter 6  
Size: 505 amino acids; 54994 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SLC16A5: NX_O15375

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15375

    • SLC16A5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258694.1  NP_004686.1  

    ENSEMBL proteins: 
     ENSP00000463434   ENSP00000462866   ENSP00000463363   ENSP00000330141   ENSP00000390564  
     ENSP00000462267   ENSP00000440212   ENSP00000463931  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SLC16A5 
    GenScript Custom Purified and Recombinant Proteins Services for SLC16A5
    Novus Biologicals SLC16A5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC16A5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005887integral to plasma membrane TAS9425115
    GO:0016020membrane TAS9425115
    GO:0016021integral to membrane ----


    SLC16A5 for ontologies           About GeneDecksing



    SLC16A5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC16A5
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC16A5 
    GenScript Custom Superior Antibodies Services for SLC16A5
    Novus Biologicals SLC16A5 Antibody
    Search for Antibodies for SLC16A5 at Abcam  
    Uscn Antibodies for SLC16A5
    Search ThermoFisher Antibodies for SLC16A5

    Assay Products for SLC16A5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC16A5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLC16A5

    Protein Domains /
    Families
    for SLC16A5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC16A5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020846 MFS_dom
     IPR004743 Monocarb_transpt
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O15375

    ProtoNet protein and cluster: O15375

    UniProtKB/Swiss-Prot: MOT6_HUMAN, O15375
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    Function
    for SLC16A5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MOT6_HUMAN, O15375
    Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many
    monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and
    the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SLC16A5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC16A5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLC16A5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC16A5 (see all 7)
    OriGene shRNA RFP: SLC16A5
    OriGene siRNA: SLC16A5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC16A5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC16A5 (NM_004695)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC16A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC16A5
    Search LifeMap BioReagents cell lines for SLC16A5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A5

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008028monocarboxylic acid transmembrane transporter activity TAS9425115
    GO:0015293symporter activity IEA--
    GO:0015355secondary active monocarboxylate transmembrane transporter activity IEA--


    SLC16A5 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SLC16A5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC16A5

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SLC16A5 (O153753 ENSP000003301414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCLP182063I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015711organic anion transport ----
    GO:0015718monocarboxylic acid transport TAS9425115


    SLC16A5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC16A5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC16A5

    1 HMDB Compound for SLC16A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    1 DrugBank Compound for SLC16A5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16604139

    Search CenterWatch for drugs/clinical trials and news about SLC16A5 / MOT6 

    Transcripts
    for SLC16A5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC16A5 gene (2 alternative transcripts): 
    NM_001271765.1  NM_004695.3  

    Unigene Cluster for SLC16A5:

    Solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
    Hs.592095  [show with all ESTs]
    Unigene Representative Sequence: AK092512
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580123(uc002jmr.3) ENST00000578847 ENST00000585293 ENST00000578376
    ENST00000329783(uc002jmt.3) ENST00000582048 ENST00000450736(uc002jmu.3)
    ENST00000584207 ENST00000538213(uc010wrt.2) ENST00000584118

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SLC16A5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC16A5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLC16A5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC16A5 (see all 7)
    OriGene shRNA RFP: SLC16A5
    OriGene siRNA: SLC16A5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC16A5 (NM_004695)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC16A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC16A5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC16A5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC16A5

    Additional cDNA sequence: 

    AK000416.1 AK092512.1 AK304163.1 BC009684.1 BC033611.1 U59299.1 

    12 DOTS entries:

    DT.113474  DT.95324587  DT.97847273  DT.120903976  DT.100780182  DT.100780183  DT.91915859  DT.100694021 
    DT.87016314  DT.120903979  DT.92018655  DT.92421752 

    24/72 AceView cDNA sequences (see all 72):

    AK000416 BM756093 BQ892616 R69593 BQ023778 BC033611 BM772888 CR597096 
    BI335165 BM562933 BQ574078 CR618619 AW291785 BM738158 R69681 BX472434 
    BI760596 BQ685148 BM796543 BI820515 AK092512 U59299 BG436869 BG470195 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A5 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a ·
    SP1:              -     -     -     -     -     -           -     -     -                             -                                                         
    SP2:                                -     -     -           -     -     -                             -                                                         
    SP3:                                                        -     -     -                             -                                                         
    SP4:                                -     -     -           -     -     -                                                                                       
    SP5:                                -     -                 -     -     -                             -                                                         

    ExUns: 11b · 11c ^ 12
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SLC16A5

    Expression
    for SLC16A5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC16A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGTTGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC16A5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC16A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC16A5

    SOURCE GeneReport for Unigene cluster: Hs.592095

    UniProtKB/Swiss-Prot: MOT6_HUMAN, O15375
    Tissue specificity: Highly expressed in kidney

        SABiosciences Custom PCR Arrays for SLC16A5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC16A5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC16A5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC16A5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A5

    Orthologs
    for SLC16A5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC16A5 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC16A51 solute carrier family 16, member 5 (monocarboxylic more 66.11(n)
    61.63(a)    		   422117  XM_420120.3  XP_420120.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC16A56
    		 --
    		 55(a)
    		 1 ↔ 1
    		 2(114805031-114816631)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7943711 monocarboxylate transporter 6-like 57.18(n)
    50.59(a)    		   794371  XM_001919623.1  XP_001919658.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG116656
    Sln6
    		 Silnoon
    		 14(a)
    11(a)
    		 many ↔ many
    many ↔ many
    		 2R(1529160-1540288)
    2R(7732831-7739829)


    ENSEMBL Gene Tree for SLC16A5 (if available)
    TreeFam Gene Tree for SLC16A5 (if available) 

    Paralogs
    for SLC16A5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC16A5 gene
    SLC16A42  SLC16A32  SLC16A102  SLC16A112  SLC16A22  SLC16A62  SLC16A82  SLC16A142  
    SLC16A72  SLC16A12  SLC16A122  SLC16A92  SLC16A132  
    9 SIMAP similar genes for SLC16A5 using alignment to 6 protein entries:     MOT6_HUMAN (see all proteins):
    SLC16A8    SLC16A3    SLC16A7    SLC16A1    SLC16A9    SLC16A11
    SLC16A10    SLC16A12    SLC16A13

    SLC16A5 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC16A5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/26 NCBI SNPs in SLC16A5 are shown (see all 26)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1413347101,2
    		--73085810(+) TACCAC/GTGCAC 1 -- int10--------
    rs711594291,2
    		C--73086558(-) AAAAA-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs105418351,2
    		C,--73088918(+) ACTGC-/GTGTGTG 1 -- int10--------
    rs1420729021,2
    		--73088918(+) ACTGC-/GTGT  
                GTGTG     		1 -- int10--------
    rs2013670331,2
    		--73088923(+) TGTGT-/GAGTGTG 1 -- int10--------
    rs711594311,2
    		C,--73094073(-) CGGGA-/GAGGAGGA 1 -- int11Minor allele frequency- GAG:0.00NA 2
    rs105982491,2
    		C--73094075(+) CCACT-/CTCCTCCT 1 -- int10--------
    rs1438013011,2
    		C,--73094787(+) CTTTT-/TTTG  
                TTTGT     		1 -- int10--------
    rs1124713581,2
    		C,--73098503(+) ACTCG-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs585159131,2
    		----73086557(+) CTTTT-/CTTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC16A5 (73083822 - 73102257 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC16A5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC16A5
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A5

    Disorders / Diseases
    for SLC16A5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC16A5 for disorders           About MalaCards

    SLC16A5 for disorders           About GeneDecksing

    OMIM gene information: 603879    OMIM disorders: --


    Export disorders for SLC16A5 gene to outside databases

    Publications
    for SLC16A5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC16A5 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with SLC16A5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PubMed id 9425115)1, 2, 3 Price N.T.... Halestrap A.P. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). (PubMed id 16174808)1, 9 Murakami Y....Yamamoto T. (2005)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PubMed id 16604139)7 Bonen A....Hatta H. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PubMed id 12739169)1 Halestrap A.P. and Meredith D. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. (PubMed id 10510291)1 Halestrap A.P. and Price N.T. (1999)

    External Searches for SLC16A5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC16A5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9121 HGNC: 10926 AceView: SLC16A5 Ensembl:ENSG00000170190 euGenes: HUgn9121
    ECgene: SLC16A5 H-InvDB: SLC16A5

    Other Databases showing SLC16A5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC16A5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC16A5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC16A5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC16A5 gene:
    Search GeneIP for patents involving SLC16A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SLC16A5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC16A5
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SLC16A5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC16A5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC16A5  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SLC16A5   OriGene 3'-UTR Clone for SLC16A5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC16A5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC16A5   OriGene Custom Protein Services for SLC16A5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC16A5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC16A5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC16A5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A5
     GenScript Custom Purified and Recombinant Proteins Services for SLC16A5 GenScript cDNA clones with any tag delivered in your preferred vector for SLC16A5
     GenScript Custom Assay Services for SLC16A5 GenScript Custom Superior Antibodies Services for SLC16A5
     GenScript Custom overexpressing Cell Line Services for SLC16A5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC16A5 promoter
     Search Chromatin IP Primers for SLC16A5
     RT2 qPCR Primer Assay in human, mouse, rat SLC16A5
     Search GNC Networks for SLC16A5
     SABiosciences Custom PCR Arrays for SLC16A5
     Search Tocris compounds for SLC16A5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC16A5 antibodies
     SLC16A5 lysates
     Search for Antibodies for SLC16A5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC16A5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SLC16A5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SLC16A5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SLC16A5
     SwitchGear Promoter luciferase reporter plasmids for SLC16A5
     Search ThermoFisher Antibodies for SLC16A5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A5
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SLC16A5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4