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Aliases for SLC16A5 Gene

Aliases for SLC16A5 Gene

  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 5 2 3
  • Solute Carrier Family 16, Member 5 (Monocarboxylic Acid Transporter 6) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 5 2 3
  • Monocarboxylate Transporter 5 3 4
  • MCT5 3 4
  • MCT6 3 4
  • Solute Carrier Family 16 Member 5 4
  • Monocarboxylate Transporter 6 3
  • MCT 5 4
  • MCT 6 4

External Ids for SLC16A5 Gene

Summaries for SLC16A5 Gene

Entrez Gene Summary for SLC16A5 Gene

  • This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC16A5 Gene

SLC16A5 (Solute Carrier Family 16 (Monocarboxylate Transporter), Member 5) is a Protein Coding gene. GO annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A5 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A5 Gene

Genomics for SLC16A5 Gene

Genomic Location for SLC16A5 Gene

Start:
75,087,727 bp from pter
End:
75,106,162 bp from pter
Size:
18,436 bases
Orientation:
Plus strand

Genomic View for SLC16A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC16A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A5 Gene

Regulatory Elements for SLC16A5 Gene

Proteins for SLC16A5 Gene

  • Protein details for SLC16A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15375-MOT6_HUMAN
    Recommended name:
    Monocarboxylate transporter 6
    Protein Accession:
    O15375
    Secondary Accessions:
    • B4E288

    Protein attributes for SLC16A5 Gene

    Size:
    505 amino acids
    Molecular mass:
    54994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A5 Gene

Proteomics data for SLC16A5 Gene at MOPED

Post-translational modifications for SLC16A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A5 Gene

Domains for SLC16A5 Gene

Gene Families for SLC16A5 Gene

Protein Domains for SLC16A5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MOT6_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.:
    • O15375
genes like me logo Genes that share domains with SLC16A5: view

Function for SLC16A5 Gene

Molecular function for SLC16A5 Gene

UniProtKB/Swiss-Prot Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS 9425115
GO:0015129 lactate transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0015355 secondary active monocarboxylate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC16A5 Gene

Localization for SLC16A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A5 Gene COMPARTMENTS Subcellular localization image for SLC16A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane TAS 9425115
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC16A5: view

Pathways for SLC16A5 Gene

SuperPathways for SLC16A5 Gene

No Data Available

Interacting Proteins for SLC16A5 Gene

Gene Ontology (GO) - Biological Process for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015711 organic anion transport --
GO:0015718 monocarboxylic acid transport TAS 9425115
GO:0035879 plasma membrane lactate transport IBA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC16A5: view

No data available for Pathways by source for SLC16A5 Gene

Compounds for SLC16A5 Gene

(1) HMDB Compounds for SLC16A5 Gene

Compound Synonyms Cas Number PubMed IDs
Pyruvic acid
  • 2-Oxopropanoate
127-17-3

(1) Drugbank Compounds for SLC16A5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyruvic acid
  • 2-Oxopropanoate
127-17-3 target
genes like me logo Genes that share compounds with SLC16A5: view

Transcripts for SLC16A5 Gene

Unigene Clusters for SLC16A5 Gene

Solute carrier family 16, member 5 (monocarboxylic acid transporter 6):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - -
SP10: - - - - - - - -
SP11: - - - -
SP12: -
SP13: -

ExUns: 11b · 11c ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLC16A5 Gene

GeneLoc Exon Structure for
SLC16A5
ECgene alternative splicing isoforms for
SLC16A5

Expression for SLC16A5 Gene

mRNA expression in normal human tissues for SLC16A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A5 Gene

This gene is overexpressed in Kidney - Cortex (8.1) and Whole Blood (6.0).

SOURCE GeneReport for Unigene cluster for SLC16A5 Gene Hs.592095

mRNA Expression by UniProt/SwissProt for SLC16A5 Gene

O15375-MOT6_HUMAN
Tissue specificity: Highly expressed in kidney
genes like me logo Genes that share expressions with SLC16A5: view

Orthologs for SLC16A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A5 36
  • 99.12 (n)
  • 99.34 (a)
SLC16A5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC16A5 36
  • 81.63 (n)
  • 76.86 (a)
SLC16A5 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A5 36
  • 84.17 (n)
  • 81.48 (a)
SLC16A5 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a5 36
  • 76.53 (n)
  • 69.32 (a)
Slc16a5 16
Slc16a5 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A5 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A5 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a5 36
  • 76.82 (n)
  • 69.09 (a)
chicken
(Gallus gallus)
Aves SLC16A5 36
  • 63.19 (n)
  • 57.78 (a)
SLC16A5 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A5 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a5 36
  • 58.05 (n)
  • 53.48 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794371 36
  • 56.55 (n)
  • 49.65 (a)
slc16a5 37
  • 42 (a)
OneToMany
SLC16A5 (1 of 2) 37
  • 37 (a)
OneToMany
Species with no ortholog for SLC16A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A5 Gene

ENSEMBL:
Gene Tree for SLC16A5 (if available)
TreeFam:
Gene Tree for SLC16A5 (if available)

Paralogs for SLC16A5 Gene

Selected SIMAP similar genes for SLC16A5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC16A5: view

Variants for SLC16A5 Gene

Sequence variations from dbSNP and Humsavar for SLC16A5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3935680 -- 75,099,733(-) ggccg(A/G)gcgcg intron-variant
rs4238978 -- 75,100,856(+) TGGTA(A/G)AAGGG intron-variant
rs4261583 -- 75,098,908(+) aggat(A/G)gggag intron-variant
rs4278783 -- 75,102,658(+) GATCC(A/G)GGAGG intron-variant
rs4442855 -- 75,104,453(+) TCACT(C/T)TTGTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC16A5 Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv908753 CNV Loss 21882294
nsv908756 CNV Loss 21882294
nsv470602 CNV Loss 18288195
dgv567e199 CNV Deletion 23128226
nsv908757 CNV Loss 21882294

Relevant External Links for SLC16A5 Gene

HapMap Linkage Disequilibrium report
SLC16A5

Disorders for SLC16A5 Gene

No disorders were found for SLC16A5 Gene.

No data available for UniProtKB/Swiss-Prot for SLC16A5 Gene

Publications for SLC16A5 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). (PMID: 16174808) Murakami Y. … Yamamoto T. (Drug Metab. Dispos. 2005) 3 23
  5. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PMID: 16604139) Bonen A. … Hatta H. (Appl Physiol Nutr Metab 2006) 25

Products for SLC16A5 Gene

Sources for SLC16A5 Gene

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