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Aliases for SLC16A5 Gene

Aliases for SLC16A5 Gene

  • Solute Carrier Family 16 Member 5 2 3 4 5
  • Solute Carrier Family 16, Member 5 (Monocarboxylic Acid Transporter 6) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 5 2 3
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 5 2 3
  • Monocarboxylate Transporter 5 3 4
  • MCT5 3 4
  • MCT6 3 4
  • Monocarboxylate Transporter 6 3
  • MCT 5 4
  • MCT 6 4

External Ids for SLC16A5 Gene

Previous GeneCards Identifiers for SLC16A5 Gene

  • GC17P073054
  • GC17P076143
  • GC17P073547
  • GC17P073680
  • GC17P073681
  • GC17P070595
  • GC17P073084
  • GC17P068493
  • GC17P075094

Summaries for SLC16A5 Gene

Entrez Gene Summary for SLC16A5 Gene

  • This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC16A5 Gene

SLC16A5 (Solute Carrier Family 16 Member 5) is a Protein Coding gene. GO annotations related to this gene include symporter activity and lactate transmembrane transporter activity. An important paralog of this gene is SLC16A8.

UniProtKB/Swiss-Prot for SLC16A5 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A5 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A5 Gene

Genomics for SLC16A5 Gene

Regulatory Elements for SLC16A5 Gene

Enhancers for SLC16A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075085 1.7 FANTOM5 Ensembl ENCODE 13.7 +3.8 3769 11.9 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 ENSG00000264829 MGC16275 SLC16A5 CDR2L ENSG00000267342 MIF4GD NAT9 MRPS7 MRPL58 MYO15B
GH17F075075 1.6 FANTOM5 Ensembl ENCODE 8.2 -8.9 -8927 6.0 MLX ARID4B DMAP1 ZNF48 ZNF143 FOS SP5 MXD4 TBX21 PPARG ATP5H HN1 KCTD2 MRPS7 TMEM94 MIR6785 TRIM80P SLC16A5 HID1 MRPL58
GH17F075083 1.3 Ensembl ENCODE 8.5 -3.5 -3474 1.1 MLX ARID4B FEZF1 ZNF48 SLC30A9 ZNF202 SP5 NFYC MXD4 PPARG UNK NUP85 ENSG00000266980 NT5C ENSG00000267342 NAT9 TRIM65 H3F3B MRPL38 CDK3
GH17F075104 1 ENCODE 9.9 +17.8 17836 1.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 ZNF121 GLIS2 ZNF302 ZNF143 NT5C ENSG00000264829 UNK ENSG00000266980 NUP85 MYO15B SLC16A5 MRPS7 CDR2L ARMC7
GH17F075307 1.8 FANTOM5 Ensembl ENCODE 4.6 +226.4 226359 14.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF263 SP3 NFYC TBX21 SSRP1 UNK GRB2 ENSG00000264829 NAT9 CDK3 ENSG00000267342 MRPS7 NUP85 MIF4GD TEN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353208 373 1401 HDGF ZFP64 ARID4B SIN3A ETS1 ZNF143 SP3 SP5 JUNB REST

Genomic Location for SLC16A5 Gene

Chromosome:
17
Start:
75,087,727 bp from pter
End:
75,106,162 bp from pter
Size:
18,436 bases
Orientation:
Plus strand

Genomic View for SLC16A5 Gene

Genes around SLC16A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A5 Gene

Proteins for SLC16A5 Gene

  • Protein details for SLC16A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15375-MOT6_HUMAN
    Recommended name:
    Monocarboxylate transporter 6
    Protein Accession:
    O15375
    Secondary Accessions:
    • B4E288

    Protein attributes for SLC16A5 Gene

    Size:
    505 amino acids
    Molecular mass:
    54994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A5 Gene

Post-translational modifications for SLC16A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A5 Gene

Domains & Families for SLC16A5 Gene

Gene Families for SLC16A5 Gene

Protein Domains for SLC16A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A5 Gene

Graphical View of Domain Structure for InterPro Entry

O15375

UniProtKB/Swiss-Prot:

MOT6_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A5: view

Function for SLC16A5 Gene

Molecular function for SLC16A5 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IEA,TAS 9425115
GO:0015129 lactate transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A5: view
genes like me logo Genes that share phenotypes with SLC16A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A5 Gene

Localization for SLC16A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9425115
GO:0016020 membrane IEA,TAS 9425115
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A5: view

Pathways & Interactions for SLC16A5 Gene

SuperPathways for SLC16A5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport IEA,TAS 9425115
GO:0035879 plasma membrane lactate transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A5 Gene

Drugs & Compounds for SLC16A5 Gene

(5) Drugs for SLC16A5 Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0
7ACC1 Pharma 0
7ACC2 Pharma 0
AR-C155858 Pharma MCT1 and MCT2 inhibitor, MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 0
UK-5099 Pharma MCTs and MPC inhibitor, MCT inhibitor; also inhibits of pyruvate transport 0

(1) Additional Compounds for SLC16A5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 13800
227321-12-2

(3) Tocris Compounds for SLC16A5 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1

(2) ApexBio Compounds for SLC16A5 Gene

Compound Action Cas Number
7ACC1 50995-74-9
7ACC2 1472624-85-3
genes like me logo Genes that share compounds with SLC16A5: view

Transcripts for SLC16A5 Gene

Unigene Clusters for SLC16A5 Gene

Solute carrier family 16, member 5 (monocarboxylic acid transporter 6):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - -
SP10: - - - - - - - -
SP11: - - - -
SP12: -
SP13: -

ExUns: 11b · 11c ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLC16A5 Gene

GeneLoc Exon Structure for
SLC16A5
ECgene alternative splicing isoforms for
SLC16A5

Expression for SLC16A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A5 Gene

This gene is overexpressed in Kidney - Cortex (x8.1) and Whole Blood (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of SLC16A5 Gene:

SLC16A5

SOURCE GeneReport for Unigene cluster for SLC16A5 Gene:

Hs.592095

mRNA Expression by UniProt/SwissProt for SLC16A5 Gene:

O15375-MOT6_HUMAN
Tissue specificity: Highly expressed in kidney.
genes like me logo Genes that share expression patterns with SLC16A5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC16A5 Gene

Orthologs for SLC16A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A5 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia SLC16A5 34 35
  • 84.17 (n)
cow
(Bos Taurus)
Mammalia SLC16A5 34 35
  • 81.63 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a5 34
  • 76.82 (n)
mouse
(Mus musculus)
Mammalia Slc16a5 34 16 35
  • 76.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A5 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A5 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A5 34 35
  • 63.19 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A5 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a5 34
  • 58.05 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC794371 34
  • 56.55 (n)
slc16a5 35
  • 42 (a)
OneToMany
SLC16A5 (1 of 2) 35
  • 37 (a)
OneToMany
Species where no ortholog for SLC16A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A5 Gene

ENSEMBL:
Gene Tree for SLC16A5 (if available)
TreeFam:
Gene Tree for SLC16A5 (if available)

Paralogs for SLC16A5 Gene

(8) SIMAP similar genes for SLC16A5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC16A5: view

Variants for SLC16A5 Gene

Sequence variations from dbSNP and Humsavar for SLC16A5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10541835 -- 75,092,823(+) ACTGC(-/GT)GTGTG intron-variant, upstream-variant-2KB
rs10598249 -- 75,097,978(+) CCACT(-/CTC)CTCCT intron-variant
rs10642740 -- 75,094,684(+) GTCTC(-/AA/AAA/AAAA)AAAAA intron-variant
rs10664711 -- 75,094,685(+) TCTCA(-/A/AAA)AAAAA intron-variant
rs10689822 -- 75,094,697(+) AAAAA(-/AA)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A5 Gene

Variant ID Type Subtype PubMed ID
nsv470602 CNV loss 18288195
esv3641257 CNV loss 21293372
dgv567e199 CNV deletion 23128226

Variation tolerance for SLC16A5 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A5 Gene

Disorders for SLC16A5 Gene

Relevant External Links for SLC16A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A5

No disorders were found for SLC16A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A5 Gene

Publications for SLC16A5 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 64
  2. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). (PMID: 16174808) Murakami Y. … Yamamoto T. (Drug Metab. Dispos. 2005) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. (PMID: 22911660) Sugito K. … Nagase H. (Pediatr Blood Cancer 2013) 3 64

Products for SLC16A5 Gene

Sources for SLC16A5 Gene

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