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Aliases for SLC16A5 Gene

Aliases for SLC16A5 Gene

  • Solute Carrier Family 16 Member 5 2 3 4
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 5 2 3 5
  • Solute Carrier Family 16, Member 5 (Monocarboxylic Acid Transporter 6) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 5 2 3
  • Monocarboxylate Transporter 5 3 4
  • MCT5 3 4
  • MCT6 3 4
  • MCT 5 4
  • MCT 6 4

External Ids for SLC16A5 Gene

Previous GeneCards Identifiers for SLC16A5 Gene

  • GC17P073054
  • GC17P076143
  • GC17P073547
  • GC17P073680
  • GC17P073681
  • GC17P070595
  • GC17P073084
  • GC17P068493

Summaries for SLC16A5 Gene

Entrez Gene Summary for SLC16A5 Gene

  • This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC16A5 Gene

SLC16A5 (Solute Carrier Family 16 Member 5) is a Protein Coding gene. GO annotations related to this gene include symporter activity and lactate transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A5 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A5 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A5 Gene

Genomics for SLC16A5 Gene

Regulatory Elements for SLC16A5 Gene

Promoters for SLC16A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC16A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC16A5 Gene

Chromosome:
17
Start:
75,087,727 bp from pter
End:
75,106,162 bp from pter
Size:
18,436 bases
Orientation:
Plus strand

Genomic View for SLC16A5 Gene

Genes around SLC16A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A5 Gene

Proteins for SLC16A5 Gene

  • Protein details for SLC16A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15375-MOT6_HUMAN
    Recommended name:
    Monocarboxylate transporter 6
    Protein Accession:
    O15375
    Secondary Accessions:
    • B4E288

    Protein attributes for SLC16A5 Gene

    Size:
    505 amino acids
    Molecular mass:
    54994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A5 Gene

Proteomics data for SLC16A5 Gene at MOPED

Post-translational modifications for SLC16A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A5 Gene

Domains & Families for SLC16A5 Gene

Gene Families for SLC16A5 Gene

Protein Domains for SLC16A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A5 Gene

Graphical View of Domain Structure for InterPro Entry

O15375

UniProtKB/Swiss-Prot:

MOT6_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A5: view

Function for SLC16A5 Gene

Molecular function for SLC16A5 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015129 lactate transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC16A5: view
genes like me logo Genes that share phenotypes with SLC16A5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A5 Gene

Localization for SLC16A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A5 Gene COMPARTMENTS Subcellular localization image for SLC16A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9425115
genes like me logo Genes that share ontologies with SLC16A5: view

Pathways & Interactions for SLC16A5 Gene

SuperPathways for SLC16A5 Gene

No Data Available

Interacting Proteins for SLC16A5 Gene

Gene Ontology (GO) - Biological Process for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A5 Gene

Drugs & Compounds for SLC16A5 Gene

(1) Drugs for SLC16A5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0

(4) Additional Compounds for SLC16A5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AR-C155858
496791-37-8
CHC
28166-41-8
SR 13800
227321-12-2
UK 5099
56396-35-1

(4) Tocris Compounds for SLC16A5 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1
genes like me logo Genes that share compounds with SLC16A5: view

Transcripts for SLC16A5 Gene

Unigene Clusters for SLC16A5 Gene

Solute carrier family 16, member 5 (monocarboxylic acid transporter 6):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - -
SP10: - - - - - - - -
SP11: - - - -
SP12: -
SP13: -

ExUns: 11b · 11c ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLC16A5 Gene

GeneLoc Exon Structure for
SLC16A5
ECgene alternative splicing isoforms for
SLC16A5

Expression for SLC16A5 Gene

mRNA expression in normal human tissues for SLC16A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A5 Gene

This gene is overexpressed in Kidney - Cortex (x8.1) and Whole Blood (x6.0).

SOURCE GeneReport for Unigene cluster for SLC16A5 Gene Hs.592095

mRNA Expression by UniProt/SwissProt for SLC16A5 Gene

O15375-MOT6_HUMAN
Tissue specificity: Highly expressed in kidney.
genes like me logo Genes that share expression patterns with SLC16A5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC16A5 Gene

Orthologs for SLC16A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC16A5 35
  • 81.63 (n)
  • 76.86 (a)
SLC16A5 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A5 35
  • 84.17 (n)
  • 81.48 (a)
SLC16A5 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a5 35
  • 76.53 (n)
  • 69.32 (a)
Slc16a5 16
Slc16a5 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC16A5 35
  • 99.12 (n)
  • 99.34 (a)
SLC16A5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a5 35
  • 76.82 (n)
  • 69.09 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC16A5 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A5 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A5 35
  • 63.19 (n)
  • 57.78 (a)
SLC16A5 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A5 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a5 35
  • 58.05 (n)
  • 53.48 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794371 35
  • 56.55 (n)
  • 49.65 (a)
slc16a5 36
  • 42 (a)
OneToMany
SLC16A5 (1 of 2) 36
  • 37 (a)
OneToMany
Species with no ortholog for SLC16A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A5 Gene

ENSEMBL:
Gene Tree for SLC16A5 (if available)
TreeFam:
Gene Tree for SLC16A5 (if available)

Paralogs for SLC16A5 Gene

(8) SIMAP similar genes for SLC16A5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC16A5: view

Variants for SLC16A5 Gene

Sequence variations from dbSNP and Humsavar for SLC16A5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3935680 -- 75,099,733(-) ggccg(A/G)gcgcg intron-variant
rs4261583 -- 75,098,908(+) aggat(A/G)gggag intron-variant
rs4788862 -- 75,087,301(+) CTGCA(C/G)TGAGC upstream-variant-2KB
rs4788863 -- 75,093,757(+) CTGAA(C/T)TGCAA reference, synonymous-codon
rs4788864 -- 75,094,422(+) TGGCT(C/T)ACGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A5 Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv908753 CNV Loss 21882294
nsv908756 CNV Loss 21882294
nsv470602 CNV Loss 18288195
dgv567e199 CNV Deletion 23128226
nsv908757 CNV Loss 21882294

Variation tolerance for SLC16A5 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A5 Gene

HapMap Linkage Disequilibrium report
SLC16A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A5 Gene

Disorders for SLC16A5 Gene

Relevant External Links for SLC16A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A5

No disorders were found for SLC16A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A5 Gene

Publications for SLC16A5 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 67
  2. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PMID: 16604139) Bonen A. … Hatta H. (Appl Physiol Nutr Metab 2006) 25 26
  3. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). (PMID: 16174808) Murakami Y. … Yamamoto T. (Drug Metab. Dispos. 2005) 3 23
  4. Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. (PMID: 22911660) Sugito K. … Nagase H. (Pediatr Blood Cancer 2013) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SLC16A5 Gene

Sources for SLC16A5 Gene

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