Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC16A4 Gene

Aliases for SLC16A4 Gene

  • Solute Carrier Family 16 Member 4 2 3 4 5
  • Solute Carrier Family 16, Member 4 (Monocarboxylic Acid Transporter 5) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 2 3
  • Monocarboxylate Transporter 4 3 4
  • MCT 4 3 4
  • MCT 5 3 4
  • MCT4 3 4
  • MCT5 3 4
  • Solute Carrier Family 16, Member 4 2

External Ids for SLC16A4 Gene

Previous GeneCards Identifiers for SLC16A4 Gene

  • GC01M111321
  • GC01M109772
  • GC01M110007
  • GC01M110204
  • GC01M110617
  • GC01M110905
  • GC01M108777

Summaries for SLC16A4 Gene

GeneCards Summary for SLC16A4 Gene

SLC16A4 (Solute Carrier Family 16 Member 4) is a Protein Coding gene. Diseases associated with SLC16A4 include breast papillary carcinoma. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A4 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Wiki entry for SLC16A4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A4 Gene

Genomics for SLC16A4 Gene

Regulatory Elements for SLC16A4 Gene

Promoters for SLC16A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC16A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC16A4 Gene

Chromosome:
1
Start:
110,362,848 bp from pter
End:
110,391,409 bp from pter
Size:
28,562 bases
Orientation:
Minus strand

Genomic View for SLC16A4 Gene

Genes around SLC16A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A4 Gene

Proteins for SLC16A4 Gene

  • Protein details for SLC16A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15374-MOT5_HUMAN
    Recommended name:
    Monocarboxylate transporter 5
    Protein Accession:
    O15374
    Secondary Accessions:
    • A8K3V5
    • B2R9C9
    • B4DJ67
    • B4DPX7
    • E7EPY8
    • G3V175
    • Q5T612
    • Q8WU09

    Protein attributes for SLC16A4 Gene

    Size:
    487 amino acids
    Molecular mass:
    54022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A4 Gene

Proteomics data for SLC16A4 Gene at MOPED

Post-translational modifications for SLC16A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A4 Gene

Domains & Families for SLC16A4 Gene

Gene Families for SLC16A4 Gene

Protein Domains for SLC16A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A4 Gene

Graphical View of Domain Structure for InterPro Entry

O15374

UniProtKB/Swiss-Prot:

MOT5_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A4: view

Function for SLC16A4 Gene

Molecular function for SLC16A4 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015129 lactate transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC16A4: view
genes like me logo Genes that share phenotypes with SLC16A4: view

Animal Model Products

CRISPR Products

miRNA for SLC16A4 Gene

miRTarBase miRNAs that target SLC16A4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A4 Gene

Localization for SLC16A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A4 Gene COMPARTMENTS Subcellular localization image for SLC16A4 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9425115
genes like me logo Genes that share ontologies with SLC16A4: view

Pathways & Interactions for SLC16A4 Gene

SuperPathways for SLC16A4 Gene

No Data Available

Interacting Proteins for SLC16A4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000358794%0d%0a9606.ENSP00000333769%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000358794 O15374-MOT5_HUMAN for SLC16A4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A4 Gene

Drugs & Compounds for SLC16A4 Gene

(1) Drugs for SLC16A4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0

(2) Additional Compounds for SLC16A4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC16A4: view

Transcripts for SLC16A4 Gene

Unigene Clusters for SLC16A4 Gene

Solute carrier family 16, member 4 (monocarboxylic acid transporter 5):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - -
SP2: -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for SLC16A4 Gene

GeneLoc Exon Structure for
SLC16A4
ECgene alternative splicing isoforms for
SLC16A4

Expression for SLC16A4 Gene

mRNA expression in normal human tissues for SLC16A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A4 Gene

This gene is overexpressed in Kidney - Cortex (x9.3).

Protein differential expression in normal tissues from HIPED for SLC16A4 Gene

This gene is overexpressed in Urine (35.4), Kidney (19.9), and Placenta (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC16A4 Gene



SOURCE GeneReport for Unigene cluster for SLC16A4 Gene Hs.351306

genes like me logo Genes that share expression patterns with SLC16A4: view

Protein tissue co-expression partners for SLC16A4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC16A4 Gene

Orthologs for SLC16A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A4 35
  • 96.76 (n)
  • 96.47 (a)
SLC16A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC16A4 36
  • 82 (a)
OneToOne
SLC16A4 35
  • 88.13 (n)
  • 85.09 (a)
dog
(Canis familiaris)
Mammalia SLC16A4 35
  • 86.39 (n)
  • 80.27 (a)
SLC16A4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a4 16
Slc16a4 35
  • 84.57 (n)
  • 83.26 (a)
Slc16a4 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A4 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A4 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a4 35
  • 86.27 (n)
  • 83.44 (a)
chicken
(Gallus gallus)
Aves SLC16A4 35
  • 61.12 (n)
  • 58.53 (a)
SLC16A4 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A4 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc16a4 36
  • 44 (a)
OneToOne
slc16a4 35
  • 57.85 (n)
  • 53.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for SLC16A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A4 Gene

ENSEMBL:
Gene Tree for SLC16A4 (if available)
TreeFam:
Gene Tree for SLC16A4 (if available)

Paralogs for SLC16A4 Gene

(5) SIMAP similar genes for SLC16A4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC16A4: view

Variants for SLC16A4 Gene

Sequence variations from dbSNP and Humsavar for SLC16A4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2271885 - 110,379,093(-) TCTAC(A/C)ATGGG intron-variant, nc-transcript-variant, reference, missense
rs35157487 - 110,379,330(+) CAATG(C/T)GATAG intron-variant, nc-transcript-variant, reference, missense
rs884684 -- 110,390,053(+) GAAAT(G/T)TAATA intron-variant
rs884685 -- 110,390,085(+) TTCCC(C/T)ATGAT intron-variant
rs924248 -- 110,384,873(+) TGGGC(A/G)TAGTG intron-variant

Variation tolerance for SLC16A4 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A4 Gene

HapMap Linkage Disequilibrium report
SLC16A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC16A4 Gene

Disorders for SLC16A4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast papillary carcinoma
  • breast solid papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC16A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A4
genes like me logo Genes that share disorders with SLC16A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A4 Gene

Publications for SLC16A4 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 67
  2. Hypoxia and lactate production in trophoblast cells. (PMID: 17275903) Kay H.H. … Tsoi S. (Placenta 2007) 23 25 26
  3. MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment. (PMID: 16110503) Han M. … Linask K.K. (Dev. Dyn. 2006) 23 25 26
  4. Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. (PMID: 16604139) Bonen A. … Hatta H. (Appl Physiol Nutr Metab 2006) 23 25 26
  5. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. (PMID: 15953344) Pierre K. … Pellerin L. (J. Neurochem. 2005) 23 25 26

Products for SLC16A4 Gene

Sources for SLC16A4 Gene

Back to Top

Content