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Aliases for SLC16A4 Gene

Aliases for SLC16A4 Gene

  • Solute Carrier Family 16 Member 4 2 3 4 5
  • Solute Carrier Family 16, Member 4 (Monocarboxylic Acid Transporter 5) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 2 3
  • Monocarboxylate Transporter 4 3 4
  • MCT 4 3 4
  • MCT 5 3 4
  • MCT4 3 4
  • MCT5 3 4
  • Solute Carrier Family 16, Member 4 2
  • Monocarboxylate Transporter 5 3

External Ids for SLC16A4 Gene

Previous GeneCards Identifiers for SLC16A4 Gene

  • GC01M111321
  • GC01M109772
  • GC01M110007
  • GC01M110204
  • GC01M110617
  • GC01M110905
  • GC01M108777

Summaries for SLC16A4 Gene

GeneCards Summary for SLC16A4 Gene

SLC16A4 (Solute Carrier Family 16 Member 4) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A12.

UniProtKB/Swiss-Prot for SLC16A4 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Wiki entry for SLC16A4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A4 Gene

Genomics for SLC16A4 Gene

Regulatory Elements for SLC16A4 Gene

Enhancers for SLC16A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G110383 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13 +6.7 6695 3.1 PKNOX1 YY1 FOS RELB IKZF2 CREM SMARCA5 ZNF362 HCFC1 CBFB PROK1 RBM15 SLC16A4 LAMTOR5 LOC440600 LAMTOR5-AS1 STRIP1 CD53 GC01P110380
GH01G110406 1.2 ENCODE 18.1 -16.4 -16426 3.3 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 PROK1 SLC16A4 GNAI3 CEPT1 ENSG00000258634 LAMTOR5-AS1 LAMTOR5
GH01G110392 0.9 Ensembl ENCODE 19.1 -2.4 -2369 3.4 CEBPB ATF2 ZNF507 FOSL1 JUND ZNF316 CEBPA FOS NFE2 EMSY SLC16A4 PROK1 LOC440600 RBM15 LAMTOR5-AS1 LAMTOR5
GH01G110380 1 Ensembl ENCODE dbSUPER 16.8 +10.3 10309 1.4 ZNF274 EBF1 MYC PROK1 SLC16A4 LOC440600 RBM15 GC01P110380
GH01G110346 2 dbSUPER 8.1 +42.2 42224 5.6 PKNOX1 ARNT FEZF1 ZNF2 TCF12 ZNF766 GATA2 JUNB ZNF518A ZNF592 PROK1 KCNC4 KCNC4-AS1 SLC16A4 LAMTOR5-AS1 LAMTOR5 GC01M110350
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A4 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011266 709 601 CTCF CHD1 SP2 ZSCAN21 ZFHX2 POLR2A SMARCA4 ZNF341 PATZ1 FOS

Genomic Location for SLC16A4 Gene

Chromosome:
1
Start:
110,362,848 bp from pter
End:
110,391,409 bp from pter
Size:
28,562 bases
Orientation:
Minus strand

Genomic View for SLC16A4 Gene

Genes around SLC16A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A4 Gene

Proteins for SLC16A4 Gene

  • Protein details for SLC16A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15374-MOT5_HUMAN
    Recommended name:
    Monocarboxylate transporter 5
    Protein Accession:
    O15374
    Secondary Accessions:
    • A8K3V5
    • B2R9C9
    • B4DJ67
    • B4DPX7
    • E7EPY8
    • G3V175
    • Q5T612
    • Q8WU09

    Protein attributes for SLC16A4 Gene

    Size:
    487 amino acids
    Molecular mass:
    54022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A4 Gene

Post-translational modifications for SLC16A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A4 Gene

Domains & Families for SLC16A4 Gene

Gene Families for SLC16A4 Gene

Protein Domains for SLC16A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A4 Gene

Graphical View of Domain Structure for InterPro Entry

O15374

UniProtKB/Swiss-Prot:

MOT5_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A4: view

Function for SLC16A4 Gene

Molecular function for SLC16A4 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS 9425115
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A4: view
genes like me logo Genes that share phenotypes with SLC16A4: view

Animal Model Products

CRISPR Products

miRNA for SLC16A4 Gene

miRTarBase miRNAs that target SLC16A4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A4 Gene

Localization for SLC16A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9425115
GO:0016020 membrane TAS 9425115
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A4: view

Pathways & Interactions for SLC16A4 Gene

SuperPathways for SLC16A4 Gene

No Data Available

Interacting Proteins for SLC16A4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000358794%0d%0a9606.ENSP00000333769%0d%0a
Selected Interacting proteins: ENSP00000358794 O15374-MOT5_HUMAN for SLC16A4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport TAS 9425115
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A4 Gene

Drugs & Compounds for SLC16A4 Gene

(2) Drugs for SLC16A4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0

(1) Additional Compounds for SLC16A4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC16A4: view

Transcripts for SLC16A4 Gene

Unigene Clusters for SLC16A4 Gene

Solute carrier family 16, member 4 (monocarboxylic acid transporter 5):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - -
SP2: -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for SLC16A4 Gene

GeneLoc Exon Structure for
SLC16A4
ECgene alternative splicing isoforms for
SLC16A4

Expression for SLC16A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A4 Gene

This gene is overexpressed in Kidney - Cortex (x9.3).

Protein differential expression in normal tissues from HIPED for SLC16A4 Gene

This gene is overexpressed in Urine (35.4), Kidney (19.9), and Placenta (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC16A4 Gene



Protein tissue co-expression partners for SLC16A4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC16A4 Gene:

SLC16A4

SOURCE GeneReport for Unigene cluster for SLC16A4 Gene:

Hs.351306

Evidence on tissue expression from TISSUES for SLC16A4 Gene

  • Kidney(4.4)
  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC16A4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A4 Gene

Orthologs for SLC16A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A4 34 35
  • 96.76 (n)
cow
(Bos Taurus)
Mammalia SLC16A4 34 35
  • 88.13 (n)
dog
(Canis familiaris)
Mammalia SLC16A4 34 35
  • 86.39 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a4 34
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Slc16a4 34 16 35
  • 84.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A4 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A4 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A4 34 35
  • 61.12 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A4 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc16a4 34 35
  • 57.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for SLC16A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A4 Gene

ENSEMBL:
Gene Tree for SLC16A4 (if available)
TreeFam:
Gene Tree for SLC16A4 (if available)

Paralogs for SLC16A4 Gene

(5) SIMAP similar genes for SLC16A4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC16A4: view

Variants for SLC16A4 Gene

Sequence variations from dbSNP and Humsavar for SLC16A4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000032405 -- 110,372,347(+) TTAGG(-/T)TAAGT intron-variant, nc-transcript-variant
rs1000037350 -- 110,364,078(+) CTTAC(A/C)CCATC intron-variant
rs1000110280 -- 110,370,928(+) AGAAG(A/G)AGGAT intron-variant
rs1000141406 -- 110,370,596(+) TAAAA(C/T)ACAAA intron-variant
rs1000153275 -- 110,381,666(+) GTCCC(A/G)TAGTC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC16A4 Gene

Variant ID Type Subtype PubMed ID
esv3346908 CNV insertion 20981092

Variation tolerance for SLC16A4 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A4 Gene

Disorders for SLC16A4 Gene

Relevant External Links for SLC16A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A4

No disorders were found for SLC16A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A4 Gene

Publications for SLC16A4 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 64
  2. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PMID: 19876643) PAcrez de Heredia F. … Trayhurn P. (Pflugers Arch. 2010) 3 22 64
  3. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PMID: 20454640) Pinheiro C. … Baltazar F. (J. Biomed. Biotechnol. 2010) 3 22 64
  4. Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration. (PMID: 19073896) Gallagher S.M. … Philp N.J. (Am. J. Physiol., Cell Physiol. 2009) 3 22 64
  5. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. (PMID: 18188595) Pinheiro C. … Baltazar F. (Virchows Arch. 2008) 3 22 64

Products for SLC16A4 Gene

Sources for SLC16A4 Gene

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