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SLC16A4 Gene

protein-coding   GIFtS: 51
GCID: GC01M110905

Solute Carrier Family 16, Member 4

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 16, Member 41 2     MCT52 3
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 41 2     MCT 42 3
Solute Carrier Family 16, Member 4 (Monocarboxylic Acid Transporter 5)1 2     MCT 52 3
Monocarboxylate Transporter 42 3     Monocarboxylate Transporter 52
MCT42 3     Solute Carrier Family 16 Member 43

External Ids:    HGNC: 109251   Entrez Gene: 91222   Ensembl: ENSG000001686797   OMIM: 6038785   UniProtKB: O153743   

Export aliases for SLC16A4 gene to outside databases

Previous GC identifers: GC01M111321 GC01M109772 GC01M110007 GC01M110204 GC01M110617 GC01M108777


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC16A4 Gene:
SLC16A4 (solute carrier family 16, member 4) is a protein-coding gene. GO annotations related to this gene include monocarboxylic acid transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC16A3.

UniProtKB/Swiss-Prot: MOT5_HUMAN, O15374
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

Gene Wiki entry for SLC16A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC16A4 gene promoter:
         Pax-2b   AML1a   FOXD3   Pax-2   Pax-2a   CUTL1   Pax-4a   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC16A4 promoter sequence
   Search Chromatin IP Primers for SLC16A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC16A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

SLC16A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M110905:  view genomic region     (about GC identifiers)

Start:
110,905,470 bp from pter      End:
110,933,704 bp from pter
Size:
28,235 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOT5_HUMAN, O15374 (See protein sequence)
Recommended Name: Monocarboxylate transporter 5  
Size: 487 amino acids; 54022 Da
Secondary accessions: A8K3V5 B2R9C9 B4DJ67 B4DPX7 E7EPY8 G3V175 Q5T612 Q8WU09
Alternative splicing: 5 isoforms:  O15374-1   O15374-2   O15374-3   O15374-4   O15374-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC16A4: NX_O15374

Explore proteomics data for SLC16A4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC16A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001188475.1  NP_001188476.1  NP_001188477.1  NP_001188478.1  NP_004687.1  

    ENSEMBL proteins: 
     ENSP00000358794   ENSP00000432495   ENSP00000358796   ENSP00000432190   ENSP00000434136  
     ENSP00000433463   ENSP00000435768   ENSP00000446087   ENSP00000394790  

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    Cloud-Clone Corp. Proteins for SLC16A4

     
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    antibodies-online kits for SLC16A4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 5
    SLC16 family of monocarboxylate transporters

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O15374

    ProtoNet protein and cluster: O15374

    UniProtKB/Swiss-Prot: MOT5_HUMAN, O15374
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    Find genes that share domains with SLC16A4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOT5_HUMAN, O15374
    Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
    many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
    isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008028monocarboxylic acid transmembrane transporter activity TAS9425115
    GO:0015293symporter activity IEA--
         
    Find genes that share ontologies with SLC16A4           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Slc16a4 (no phenotypes)

    Find genes that share phenotypes with SLC16A4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC16A4

    miRNA
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    miRTarBase miRNAs that target SLC16A4:
    hsa-mir-26b-5p (MIRT029757), hsa-mir-335-5p (MIRT018295), hsa-mir-125b-5p (MIRT045889)

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    8 qRT-PCR Assays for microRNAs that regulate SLC16A4:
    hsa-miR-10b* hsa-miR-548am hsa-miR-3140-3p hsa-miR-3658 hsa-miR-3908 hsa-miR-3942-5p hsa-miR-548x hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOT5_HUMAN, O15374: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS9425115
    GO:0016020membrane TAS9425115
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC16A4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC16A4
    Interactions:

        GeneGlobe Interaction Network for SLC16A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for SLC16A4 (O153743 ENSP000003587944) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BSGP356133, ENSP000003337694I2D: score=1 STRING: ENSP00000333769
    ASPMENSP000003563794STRING: ENSP00000356379
    BSDC1ENSP000003977594STRING: ENSP00000397759
    C1orf146ENSP000003594014STRING: ENSP00000359401
    C1orf200ENSP000003665374STRING: ENSP00000366537
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015718monocarboxylic acid transport TAS9425115
    GO:0055085transmembrane transport ----

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC16A4 (MOT5)

    1 HMDB Compound for SLC16A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    1 DrugBank Compound for SLC16A4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16604139 16110503 16213084 15953344 17275903

    2 Novoseek inferred chemical compound relationships for SLC16A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 77.5 47 19505879 (3), 11353425 (3), 14724187 (2), 17275903 (2) (see all 25)
    glucose 27.5 4 14724187 (1), 11272148 (1), 12657613 (1)



    Find genes that share compounds with SLC16A4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC16A4 gene (5 alternative transcripts): 
    NM_001201546.1  NM_001201547.1  NM_001201548.1  NM_001201549.1  NM_004696.2  

    Unigene Cluster for SLC16A4:

    Solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
    Hs.351306  [show with all ESTs]
    Unigene Representative Sequence: NM_004696
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369779(uc001dzo.2 uc009wfs.2 uc001dzp.2 uc010ovy.2 uc010ovz.2 uc001dzq.2)
    ENST00000472422 ENST00000369781 ENST00000461647 ENST00000528649 ENST00000492412
    ENST00000467986 ENST00000497687 ENST00000541986 ENST00000437429
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate SLC16A4:
    hsa-miR-10b* hsa-miR-548am hsa-miR-3140-3p hsa-miR-3658 hsa-miR-3908 hsa-miR-3942-5p hsa-miR-548x hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A4 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC16A4
      QuantiFast Probe-based Assays in human, mouse, rat SLC16A4

    Additional mRNA sequence: 

    AK129985.1 AK223307.1 AK290720.1 AK295946.1 AK298539.1 AK313735.1 AL833619.1 BC021664.1 
    BX647948.1 U59185.1 

    6 DOTS entries:

    DT.95266981  DT.99935851  DT.100022383  DT.100786235  DT.100786234  DT.100786236 

    Selected AceView cDNA sequences (see all 118):

    H01059 NM_004696 BQ216337 CA434226 BQ230007 BP346443 H88761 AU135008 
    CN484020 AA669534 BE893159 U59185 AA369517 BP345760 H88760 H03446 
    BX089176 BQ436378 BP346354 AU139066 BX505727 BG620383 BG620766 BX359053 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                                              -                                               -         
    SP2:                                -                                                                                       
    SP3:                                -     -                       -                                                         
    SP4:                                -     -                       -     -     -     -                                       
    SP5:                                                              -     -     -     -                                       


    ECgene alternative splicing isoforms for SLC16A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC16A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGCTAAA
    SLC16A4 Expression
    About this image


    SLC16A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Kidney (Urinary System)
    SLC16A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC16A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351306
        Custom PCR Arrays for SLC16A4
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC16A4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc16a41 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 84.57(n)1
    83.26(a)1
      3 (46.81 cM)5
    2296991  NM_146136.11  NP_666248.11 
     1072912305 
    chicken
    (Gallus gallus)
    Aves SLC16A41 solute carrier family 16, member 4 (monocarboxylic more 61.12(n)
    58.53(a)
      419809  XM_004934872.1  XP_004934929.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC16A46
    solute carrier family 16, member 4
    57(a)
    1 ↔ 1
    4(106564284-106582306)
    zebrafish
    (Danio rerio)
    Actinopterygii slc16a41 solute carrier family 16 (monocarboxylic acid transporters), more 57.85(n)
    53.96(a)
      567144  NM_001080599.2  NP_001074068.2 


    ENSEMBL Gene Tree for SLC16A4 (if available)
    TreeFam Gene Tree for SLC16A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC16A4 gene
    SLC16A32  SLC16A52  SLC16A112  SLC16A62  SLC16A82  SLC16A142  SLC16A72  SLC16A12  
    SLC16A122  SLC16A92  SLC16A132  
    5 SIMAP similar genes for SLC16A4 using alignment to 4 protein entries:     MOT5_HUMAN (see all proteins):
    SLC16A7    SLC16A6    SLC16A12    SLC16A14    SLC16A9

    Find genes that share paralogs with SLC16A4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC16A4 (see all 592)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs566908431,2
    C,F--110904974(+) GCTCAC/TGCCTG 5 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1928621701,2
    --110905002(+) GAGGCC/TGAGGC 5 -- ds50010--------
    rs121432821,2
    C,F,A--110905003(+) AGGCCG/AAGGCG 5 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1838529931,2
    --110905007(+) CGAGGC/TGGGTG 5 -- ds50010--------
    rs1875393251,2
    --110905077(+) ATTAAA/GAATAA 5 -- ds50010--------
    rs1923551741,2
    --110905216(+) CTGGGC/TGACAG 5 -- ds50010--------
    rs746170251,2
    F--110905218(+) GGGCGC/ACAGAG 5 -- ds50011Minor allele frequency- A:0.50NA 4
    rs1513012011,2
    C--110905256(+) AAAAG-/CAT   
      TCAGAA
    CATTC
    5 -- cds10--------
    rs1142642441,2
    F--110905324(+) TTTCCC/TATTAA 5 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1178132701,2
    C,F--110905436(+) GGGCAA/GAATTG 5 -- ds50011Minor allele frequency- G:0.02EA 120

    HapMap Linkage Disequilibrium report for SLC16A4 (110905470 - 110933704 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC16A4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC16A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603878    OMIM disorders: --


    Find genes that share disorders with SLC16A4           About GenesLikeMe


    Export disorders for SLC16A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC16A4 gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with SLC16A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PubMed id 9425115)1, 2, 3 Price N.T.... Halestrap A.P. (Biochem. J. 1998)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PubMed id 19876643)1, 9 PAcrez de Heredia F....Trayhurn P. (Pflugers Arch. 2010)
    4. MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment. (PubMed id 16110503)7, 9 Han M....Linask K.K. (Dev. Dyn. 2006)
    5. The effects of short-term sprint training on MCT expression in moderately endurance-trained runners. (PubMed id 16408234)1, 9 Bickham D.C....Cameron-Smith D. (Eur. J. Appl. Physiol. 2006)
    6. Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans. (PubMed id 14724187)1, 9 Juel C....Dela F. (J. Physiol. (Lond.) 2004)
    7. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. (PubMed id 12657613)1, 9 Philp N.J....Hjelmeland L.M. (amp 2003)
    8. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. (PubMed id 10921872)1, 9 Kirk P....Halestrap A.P. (EMBO J. 2000)
    9. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. (PubMed id 16452478)1, 9 Ullah M.S....Halestrap A.P. (J. Biol. Chem. 2006)
    10. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PubMed id 20454640)1, 9 Pinheiro C....Baltazar F. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9122 HGNC: 10925 AceView: SLC16A4 Ensembl:ENSG00000168679 euGenes: HUgn9122
    ECgene: SLC16A4 H-InvDB: SLC16A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC16A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC16A4 gene:
    Search GeneIP for patents involving SLC16A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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