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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC16A4 Gene

protein-coding   GIFtS: 51
GCID: GC01M110905

solute carrier family 16, member 4 (monocarboxylic acid...

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
 Explore 24 diseases affiliated with
SLC16A4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC16A4    

Aliases
for SLC16A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 16, Member 4 (Monocarboxylic Acid Transporter 5)1 2     Solute Carrier Family 16 Member 42 3
MCT41 2 3     MCT 42 3
MCT51 2 3     MCT 52 3
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 41 2     Monocarboxylate Transporter 52
Monocarboxylate Transporter 42 3     

External Ids:    HGNC: 109251   Entrez Gene: 91222   Ensembl: ENSG000001686797   OMIM: 6038785   UniProtKB: O153743   

Export aliases for SLC16A4 gene to outside databases

Previous GC identifers: GC01M111321 GC01M109772 GC01M110007 GC01M110204 GC01M110617 GC01M108777


Summaries
for SLC16A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MOT5_HUMAN, O15374
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many
monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and
the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

Gene Wiki entry for SLC16A4


Genomic Views
for SLC16A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC16A4 gene promoter:
         Pax-2b   AML1a   FOXD3   Pax-2   Pax-2a   CUTL1   Pax-4a   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC16A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC16A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

SLC16A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M110905:  view genomic region     (about GC identifiers)

Start:
 110,905,470 bp from pter      End:
 110,933,704 bp from pter
Size:
 28,235 bases      Orientation:
 minus strand

Proteins
for SLC16A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MOT5_HUMAN, O15374 (See protein sequence)
Recommended Name: Monocarboxylate transporter 5  
Size: 487 amino acids; 54022 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2R9C9 B4DJ67 Q5T612 Q8WU09
Alternative splicing: 3 isoforms:  O15374-1   O15374-2   O15374-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC16A4: NX_O15374

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15374

    • SLC16A4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001188475.1  NP_001188476.1  NP_001188477.1  NP_001188478.1  NP_004687.1  

    ENSEMBL proteins: 
     ENSP00000358794   ENSP00000432495   ENSP00000358796   ENSP00000432190   ENSP00000434136  
     ENSP00000433463   ENSP00000435768   ENSP00000446087   ENSP00000394790  

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    Uscn Proteins for SLC16A4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005887integral to plasma membrane TAS9425115
    GO:0016020membrane TAS9425115
    GO:0016021integral to membrane ----


    SLC16A4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC16A4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC16A4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O15374

    ProtoNet protein and cluster: O15374

    UniProtKB/Swiss-Prot: MOT5_HUMAN, O15374
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    Function
    for SLC16A4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MOT5_HUMAN, O15374
    Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many
    monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and
    the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

    miRNA
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    hsa-miR-10b* hsa-miR-548am hsa-miR-3140-3p hsa-miR-3658 hsa-miR-3908 hsa-miR-3942-5p hsa-miR-548x hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: SLC16A4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008028monocarboxylic acid transmembrane transporter activity TAS9425115
    GO:0015293symporter activity IEA--


    SLC16A4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SLC16A4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC16A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/24 Interacting proteins for SLC16A4 (O153743 ENSP000003587944) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BSGP356133, ENSP000003337694I2D: score=1 STRING: ENSP00000333769
    ASPMENSP000003563794STRING: ENSP00000356379
    BSDC1ENSP000003977594STRING: ENSP00000397759
    C1orf146ENSP000003594014STRING: ENSP00000359401
    C1orf200ENSP000003665374STRING: ENSP00000366537
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015718monocarboxylic acid transport TAS9425115
    GO:0055085transmembrane transport ----


    SLC16A4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC16A4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC16A4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC16A4

    1 HMDB Compound for SLC16A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    1 DrugBank Compound for SLC16A4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16604139 16110503 16213084 15953344 17275903

    2 Novoseek chemical compound relationships for SLC16A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 77.5 47 19505879 (3), 11353425 (3), 14724187 (2), 17275903 (2) (see all 25)
    glucose 27.5 4 14724187 (1), 11272148 (1), 12657613 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC16A4 / MOT5 

    Transcripts
    for SLC16A4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC16A4 gene (5 alternative transcripts): 
    NM_001201546.1  NM_001201547.1  NM_001201548.1  NM_001201549.1  NM_004696.2  

    Unigene Cluster for SLC16A4:

    Solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
    Hs.351306  [show with all ESTs]
    Unigene Representative Sequence: NM_004696
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369779(uc001dzo.2 uc009wfs.2 uc001dzp.2 uc010ovy.2 uc010ovz.2 uc001dzq.2)
    ENST00000472422 ENST00000369781 ENST00000461647 ENST00000528649 ENST00000492412
    ENST00000467986 ENST00000497687 ENST00000541986 ENST00000437429

    miRNA
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    hsa-miR-10b* hsa-miR-548am hsa-miR-3140-3p hsa-miR-3658 hsa-miR-3908 hsa-miR-3942-5p hsa-miR-548x hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: SLC16A4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC16A4 (see all 7)
    OriGene shRNA RFP: SLC16A4
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    Clone
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    Additional cDNA sequence: 

    AK129985.1 AK223307.1 AK290720.1 AK295946.1 AK298539.1 AK313735.1 AL833619.1 BC021664.1 
    BX647948.1 U59185.1 

    6 DOTS entries:

    DT.95266981  DT.99935851  DT.100022383  DT.100786235  DT.100786234  DT.100786236 

    24/118 AceView cDNA sequences (see all 118):

    BE893159 H01059 BP346443 AA369517 U59185 H88761 BP345760 H03446 
    BQ230007 CA434226 AA669534 BQ216337 H88760 AU135008 NM_004696 CN484020 
    BI546971 AU136895 D79128 AU139066 AK129985 AA970406 BG620383 BX505727 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                                              -                                               -         
    SP2:                                -                                                                                       
    SP3:                                -     -                       -                                                         
    SP4:                                -     -                       -     -     -     -                                       
    SP5:                                                              -     -     -     -                                       


    ECgene alternative splicing isoforms for SLC16A4

    Expression
    for SLC16A4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC16A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTGCTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC16A4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC16A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC16A4

    SOURCE GeneReport for Unigene cluster: Hs.351306
        SABiosciences Custom PCR Arrays for SLC16A4
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    In Situ
    Assay Products:     
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    Orthologs
    for SLC16A4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC16A4 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC16A41 solute carrier family 16, member 4 (monocarboxylic more 61.03(n)
    59.96(a)    		   419809  XM_417945.3  XP_417945.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC16A46
    		 --
    		 54(a)
    		 1 ↔ 1
    		 4(106566196-106582306)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc16a41 solute carrier family 16 (monocarboxylic acid transporters), more 57.78(n)
    53.96(a)    		   567144  NM_001080599.2  NP_001074068.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mct11 Monocarboxylate transporter 1 45.53(n)
    33.68(a)    		   31198  NM_057986.3  NP_477334.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea C10E2.61 Protein C10E2.6 43.32(n)
    30.63(a)    		   181724  NM_078304.2  NP_510705.1 


    ENSEMBL Gene Tree for SLC16A4 (if available)
    TreeFam Gene Tree for SLC16A4 (if available) 

    Paralogs
    for SLC16A4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC16A4 gene
    SLC16A32  SLC16A52  SLC16A102  SLC16A112  SLC16A22  SLC16A62  SLC16A82  SLC16A142  
    SLC16A72  SLC16A12  SLC16A122  SLC16A132  SLC16A92  
    6 SIMAP similar genes for SLC16A4 using alignment to 6 protein entries:     MOT5_HUMAN (see all proteins):
    SLC16A8    SLC16A7    SLC16A6    SLC16A12    SLC16A14    SLC16A9

    SLC16A4 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC16A4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/492 NCBI SNPs in SLC16A4 are shown (see all 492)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs566908431,2
    		C,--110904974(+) GCTCAC/TGCCTG 5 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1928621701,2
    		--110905002(+) GAGGCC/TGAGGC 5 -- ds50010--------
    rs121432821,2
    		C,F,A,--110905003(+) AGGCCG/AAGGCG 5 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1838529931,2
    		--110905007(+) CGAGGC/TGGGTG 5 -- ds50010--------
    rs1875393251,2
    		--110905077(+) ATTAAA/GAATAA 5 -- ds50010--------
    rs1923551741,2
    		--110905216(+) CTGGGC/TGACAG 5 -- ds50010--------
    rs746170251,2
    		F--110905218(+) GGGCGC/ACAGAG 5 -- ds50011Minor allele frequency- A:0.50NA 4
    rs1513012011,2
    		C,--110905256(+) AAAAG-/CAT   
      TCAGAA    CATTC     		5 -- ds50010--------
    rs112813311,2
    		C--110905265(+) CAGAACATTC   
      AGAA    /-    GGAGA     		5 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1142642441,2
    		--110905324(+) TTTCCC/TATTAA 5 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for SLC16A4 (110905470 - 110933704 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC16A4: --

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    Disorders / Diseases
    for SLC16A4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC16A4 for disorders           About GeneDecksing

    OMIM gene information: 603878    OMIM disorders: --

    20/24 diseases for SLC16A4 (see all 24):    About MalaCards
    chronic obstructive pulmonary disease    embryonal rhabdomyosarcoma    epithelial ovarian cancer    pulmonary disease
    rhabdomyosarcoma    ovarian cancer    colon adenocarcinoma    cervical carcinoma
    cervicitis    gastric cancer    myopathy    pancreatic cancer
    breast carcinoma    lung cancer    adenocarcinoma    prostate cancer
    breast cancer    pancreatitis    obesity    carcinoma


    Export disorders for SLC16A4 gene to outside databases

    Publications
    for SLC16A4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC16A4 gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with SLC16A4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PubMed id 9425115)1, 2, 3 Price N.T.... Halestrap A.P. (1998)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Hypoxia stimulates lactate release and modulates mono carboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PubMed id 19876643)1, 9 PAcrez de Heredia F....Trayhurn P. (2010)
    4. MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment. (PubMed id 16110503)7, 9 Han M....Linask K.K. (2006)
    5. The effects of short-term sprint training on MCT expression in moderately endurance-trained runners. (PubMed id 16408234)1, 9 Bickham D.C....Cameron-Smith D. (2006)
    6. Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans. (PubMed id 14724187)1, 9 Juel C....Dela F. (2004)
    7. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. (PubMed id 12657613)1, 9 Philp N.J....Hjelmeland L.M. (2003)
    8. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. (PubMed id 10921872)1, 9 Kirk P....Halestrap A.P. (2000)
    9. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. (PubMed id 16452478)1, 9 Ullah M.S....Halestrap A.P. (2006)
    10. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PubMed id 20454640)1, 9 Pinheiro C....Baltazar F. (2010)

    External Searches for SLC16A4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLC16A4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9122 HGNC: 10925 AceView: SLC16A4 Ensembl:ENSG00000168679 euGenes: HUgn9122
    ECgene: SLC16A4 H-InvDB: SLC16A4

    Other Databases showing SLC16A4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC16A4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC16A4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC16A4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC16A4 gene:
    Search GeneIP for patents involving SLC16A4

    GeneCards and IP:
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