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Aliases for SLC16A3 Gene

Aliases for SLC16A3 Gene

  • Solute Carrier Family 16 Member 3 2 3 4 5
  • Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 2 3
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 3 2 3
  • MCT 4 3 4
  • MCT4 3 4
  • Monocarboxylate Transporter 3 3
  • Monocarboxylate Transporter 4 3
  • MCT 3 3
  • MCT-3 3
  • MCT-4 3
  • MCT3 3

External Ids for SLC16A3 Gene

Previous GeneCards Identifiers for SLC16A3 Gene

  • GC17P079025
  • GC17P082998
  • GC17P080716
  • GC17P080865
  • GC17P077780
  • GC17P080186
  • GC17P075585

Summaries for SLC16A3 Gene

Entrez Gene Summary for SLC16A3 Gene

  • Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC16A3 Gene

SLC16A3 (Solute Carrier Family 16 Member 3) is a Protein Coding gene. Diseases associated with SLC16A3 include Exudative Vitreoretinopathy 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Pyruvate metabolism and Citric Acid (TCA) cycle. GO annotations related to this gene include poly(A) RNA binding and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A8.

UniProtKB/Swiss-Prot for SLC16A3 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A3 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

Gene Wiki entry for SLC16A3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A3 Gene

Genomics for SLC16A3 Gene

Regulatory Elements for SLC16A3 Gene

Enhancers for SLC16A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G082291 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +70.2 70237 14.7 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 TEX19 CSNK1D SLC16A3 SECTM1 CCDC57 HGS ACTG1 ENSG00000262877 ENSG00000262049 ARHGDIA
GH17G082204 2 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -22.5 -22480 3.6 HDGF PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 CCDC57 SLC16A3 SECTM1 CSNK1D NARF C17orf62 SIRT7 MAFG GC17M082163
GH17G082256 1.3 FANTOM5 ENCODE dbSUPER 11.1 +29.0 28956 1.4 SCRT1 CTCF PKNOX1 ZNF146 RFX1 NFYC SP2 RAD21 POLR2A PBX2 SLC16A3 DCXR CSNK1D C17orf62 CCDC57 NARF CD7 WDR45B SIRT7 PIR35303
GH17G082278 1.1 Ensembl ENCODE dbSUPER 12.1 +50.9 50865 1.6 L3MBTL2 NR4A1 HLF MAX MNT ZIC2 RELA ZNF592 MYC MGA TEX19 SLC16A3 CCDC57 SECTM1 GC17P082279 CSNK1D
GH17G082234 1.6 Ensembl ENCODE dbSUPER 5.6 +10.9 10859 10.2 HDGF HNRNPUL1 PKNOX1 MLX ARNT AGO1 ZFP64 SIN3A ARID4B DMAP1 ENSG00000262049 ENSG00000262663 ENSG00000262652 NARF-IT1 ARL2BPP9 OGFOD3 CSNK1D DCXR SLC16A3 GC17M082241
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000284734 894 1801 HDGF ARID4B SIN3A GLIS2 ELK1 ZNF143 SP5 REST KAT8 SREBF1

Genomic Location for SLC16A3 Gene

Chromosome:
17
Start:
82,228,397 bp from pter
End:
82,261,129 bp from pter
Size:
32,733 bases
Orientation:
Plus strand

Genomic View for SLC16A3 Gene

Genes around SLC16A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A3 Gene

Proteins for SLC16A3 Gene

  • Protein details for SLC16A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15427-MOT4_HUMAN
    Recommended name:
    Monocarboxylate transporter 4
    Protein Accession:
    O15427
    Secondary Accessions:
    • B3KXG8
    • Q2M1P8

    Protein attributes for SLC16A3 Gene

    Size:
    465 amino acids
    Molecular mass:
    49469 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A3 Gene

Post-translational modifications for SLC16A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A3 Gene

Domains & Families for SLC16A3 Gene

Gene Families for SLC16A3 Gene

Protein Domains for SLC16A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15427

UniProtKB/Swiss-Prot:

MOT4_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A3: view

Function for SLC16A3 Gene

Molecular function for SLC16A3 Gene

GENATLAS Biochemistry:
solute carrier family 16 (monocarboxylic acids transport) member 3,expressed only in the retinal pigment epithelium
UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS --
GO:0015129 lactate transmembrane transporter activity EXP 15917240
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A3: view
genes like me logo Genes that share phenotypes with SLC16A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A3

CRISPR Products

miRNA for SLC16A3 Gene

miRTarBase miRNAs that target SLC16A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A3 Gene

Localization for SLC16A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane TAS 9425115
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with SLC16A3: view

Pathways & Interactions for SLC16A3 Gene

genes like me logo Genes that share pathways with SLC16A3: view

Pathways by source for SLC16A3 Gene

Gene Ontology (GO) - Biological Process for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport TAS 9425115
GO:0035873 lactate transmembrane transport IEA --
GO:0035879 plasma membrane lactate transport IEA --
genes like me logo Genes that share ontologies with SLC16A3: view

No data available for SIGNOR curated interactions for SLC16A3 Gene

Drugs & Compounds for SLC16A3 Gene

(16) Drugs for SLC16A3 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gamma Hydroxybutyric Acid Approved, Illicit Pharma Transporter, substrate 0
Pyruvic acid Approved Nutra Target, Transporter, substrate 0
Lactic Acid Approved, Vet_approved Pharma Transporter, substrate 0
Niacin Approved, Investigational Nutra Unknown, Agonist, Transporter 923,923
alpha-ketoisovalerate Experimental Pharma Transporter, substrate 0

(3) Additional Compounds for SLC16A3 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glyoxylic acid
  • a-Ketoacetate
  • a-Ketoacetic acid
  • alpha-Ketoacetate
  • alpha-Ketoacetic acid
  • Formylformate
298-12-4
SR 13800
227321-12-2

(3) Tocris Compounds for SLC16A3 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1

(2) ApexBio Compounds for SLC16A3 Gene

Compound Action Cas Number
7ACC1 50995-74-9
7ACC2 1472624-85-3
genes like me logo Genes that share compounds with SLC16A3: view

Transcripts for SLC16A3 Gene

Unigene Clusters for SLC16A3 Gene

Solute carrier family 16, member 3 (monocarboxylic acid transporter 4):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: -
SP6: - -
SP7: - -
SP8:

Relevant External Links for SLC16A3 Gene

GeneLoc Exon Structure for
SLC16A3
ECgene alternative splicing isoforms for
SLC16A3

Expression for SLC16A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A3 Gene

This gene is overexpressed in Whole Blood (x21.2) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for SLC16A3 Gene

This gene is overexpressed in Nasal epithelium (32.8) and Breast (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC16A3 Gene



Protein tissue co-expression partners for SLC16A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC16A3 Gene:

SLC16A3

SOURCE GeneReport for Unigene cluster for SLC16A3 Gene:

Hs.500761

mRNA Expression by UniProt/SwissProt for SLC16A3 Gene:

O15427-MOT4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for SLC16A3 Gene

  • Nervous system(4.4)
  • Blood(4.2)
  • Lung(3.7)
  • Kidney(3.5)
  • Intestine(2.8)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with SLC16A3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A3 Gene

Orthologs for SLC16A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A3 34 35
  • 99.06 (n)
cow
(Bos Taurus)
Mammalia SLC16A3 34 35
  • 86.1 (n)
dog
(Canis familiaris)
Mammalia SLC16A3 34 35
  • 85.93 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a3 34
  • 84.66 (n)
mouse
(Mus musculus)
Mammalia Slc16a3 34 16 35
  • 84.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A3 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A3 34 35
  • 71.13 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A3 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a3 34
  • 68.39 (n)
Str.19 34
African clawed frog
(Xenopus laevis)
Amphibia mct3-prov 34
zebrafish
(Danio rerio)
Actinopterygii slc16a3 34 35
  • 68.64 (n)
SLC16A3 (1 of 2) 35
  • 67 (a)
OneToMany
Dr.7337 34
fruit fly
(Drosophila melanogaster)
Insecta CG8271 36
  • 35 (a)
Species where no ortholog for SLC16A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A3 Gene

ENSEMBL:
Gene Tree for SLC16A3 (if available)
TreeFam:
Gene Tree for SLC16A3 (if available)

Paralogs for SLC16A3 Gene

Variants for SLC16A3 Gene

Sequence variations from dbSNP and Humsavar for SLC16A3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000220132 -- 82,234,088(+) GCCCG(C/T)CTTGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000281959 -- 82,231,158(+) GGGCC(A/G)GGCGG intron-variant, upstream-variant-2KB
rs1000333717 -- 82,231,027(+) GGCTC(C/G/T)GCTGA intron-variant, upstream-variant-2KB
rs1000427796 -- 82,230,614(+) CTCAG(-/C)CGGTG intron-variant, upstream-variant-2KB
rs1000503363 -- 82,233,929(+) TCTGC(C/T)TCCTG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC16A3 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv995451 CNV deletion 20482838
nsv1071417 CNV deletion 25765185
nsv2166 CNV insertion 18451855
nsv428351 CNV gain 18775914
nsv476004 CNV novel sequence insertion 20440878
nsv576193 CNV loss 21841781
nsv833572 CNV loss 17160897

Variation tolerance for SLC16A3 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A3 Gene

Human Gene Mutation Database (HGMD)
SLC16A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A3 Gene

Disorders for SLC16A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 1
  • retinopathy of prematurity
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC16A3

Genetic Association Database (GAD)
SLC16A3
Human Genome Epidemiology (HuGE) Navigator
SLC16A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A3
genes like me logo Genes that share disorders with SLC16A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A3 Gene

Publications for SLC16A3 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PMID: 17502341) Wang Q. … Morris M.E. (Drug Metab. Dispos. 2007) 3 22 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLC16A3 Gene

Sources for SLC16A3 Gene

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