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SLC16A3 Gene

protein-coding   GIFtS: 64
GCID: GC17P080186

Solute Carrier Family 16 (Monocarboxylate Transporter),...

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 16 (Monocarboxylate Transporter), Member 31 2     MCT-42
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 31 2     MCT32
Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4)1 2     MCT 32
MCT42 3     Monocarboxylate Transporter 32
MCT 42 3     Monocarboxylate Transporter 42
MCT-32     Solute Carrier Family 16 Member 33

External Ids:    HGNC: 109241   Entrez Gene: 91232   Ensembl: ENSG000001415267   OMIM: 6038775   UniProtKB: O154273   

Export aliases for SLC16A3 gene to outside databases

Previous GC identifers: GC17P079025 GC17P082998 GC17P080716 GC17P080865 GC17P077780 GC17P075585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC16A3 Gene:
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked
monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to
have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the
metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682)
and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998
(PubMed 9425115)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC16A3 Gene:
SLC16A3 (solute carrier family 16 (monocarboxylate transporter), member 3) is a protein-coding gene. GO annotations related to this gene include secondary active monocarboxylate transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC16A4.

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

Gene Wiki entry for SLC16A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010663.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC16A3 gene promoter:
         PPAR-alpha   Pax-5   c-Myb   LUN-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC16A3 promoter sequence
   Search Chromatin IP Primers for SLC16A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC16A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

SLC16A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080186:  view genomic region     (about GC identifiers)

Start:
80,186,273 bp from pter      End:
80,219,005 bp from pter
Size:
32,733 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427 (See protein sequence)
Recommended Name: Monocarboxylate transporter 4  
Size: 465 amino acids; 49469 Da
Caution: Was initially assigned as monocarboxylate transporter 3 (MCT3) (PubMed:9425115). However, it was later
shown that it corresponds to monocarboxylate transporter 4 (MCT4)
Secondary accessions: B3KXG8 Q2M1P8

Explore the universe of human proteins at neXtProt for SLC16A3: NX_O15427

Explore proteomics data for SLC16A3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC16A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001035887.1  NP_001035888.1  NP_001193879.1  NP_001193880.1  NP_001193881.1  NP_004198.1  

    ENSEMBL proteins: 
     ENSP00000464625   ENSP00000462854   ENSP00000462405   ENSP00000463912   ENSP00000463063  
     ENSP00000464326   ENSP00000463880   ENSP00000463978   ENSP00000463508   ENSP00000464112  
     ENSP00000464381   ENSP00000463005   ENSP00000376152   ENSP00000376150  
    Reactome Protein details: O15427

    SLC16A3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 4
    SLC16 family of monocarboxylate transporters

    4 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR004743 Monocarb_transpt
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O15427

    ProtoNet protein and cluster: O15427

    UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    Find genes that share domains with SLC16A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOT4_HUMAN, O15427
    Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
    many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
    isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

         Genatlas biochemistry entry for SLC16A3:
    solute carrier family 16 (monocarboxylic acids transport) member 3,expressed only in the retinal pigment
    epithelium

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008028monocarboxylic acid transmembrane transporter activity TAS9425115
    GO:0015293symporter activity IEA--
    GO:0015355secondary active monocarboxylate transmembrane transporter activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SLC16A3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLC16A3:
     Decreased POU5F1-GFP protein e  Increased cell number in S and  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC16A3

    miRNA
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    miRTarBase miRNAs that target SLC16A3:
    hsa-mir-16-5p (MIRT001416), hsa-mir-98-5p (MIRT027668)

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    6 qRT-PCR Assays for microRNAs that regulate SLC16A3:
    hsa-miR-3673 hsa-miR-206 hsa-miR-1260b hsa-miR-1 hsa-miR-613 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOT4_HUMAN, O15427: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    nucleus4
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9425115
    GO:0015629actin cytoskeleton IDA--
    GO:0016020membrane TAS9425115
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC16A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC16A3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Proton-coupled monocarboxylate transport0.00
    2Citric acid cycle (TCA cycle)
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    Pyruvate metabolism0.00
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    4Hemostasis
    Hemostasis0.43
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with SLC16A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SLC16A3
        Pyruvate metabolism
    Proton-coupled monocarboxylate transport
    Basigin interactions


        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC16A3: 
              Neurotoxicity in human mouse rat
              Drug Transporters in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC16A3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC16A3 (O154273 ENSP000003761504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BSGP356133, ENSP000003337694I2D: score=2 STRING: ENSP00000333769
    SLC16A1ENSP000003586404STRING: ENSP00000358640
    SLC16A8ENSP000003217354STRING: ENSP00000321735
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0007596blood coagulation TAS--
    GO:0015711organic anion transport ----
    GO:0015718monocarboxylic acid transport TAS9425115
    GO:0044237cellular metabolic process TAS--

    Find genes that share ontologies with SLC16A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC16A3 (MOT4)

    1 HMDB Compound for SLC16A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    Selected DrugBank Compounds for SLC16A3 (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16213084
    transportersubstrate16213084 11101640
    3-Phenylpyruvic Acid-- --transportersubstrate11101640
    Acetoacetic Acid-- 541-50-4transportersubstrate11101640
    Alpha-ketoisovalerate2-Keto-3-methylbutyric acid (see all 9)759-05-7transportersubstrate11101640
    D-Lactic Acid-- 10326-41-7transportersubstrate11101640
    Formic AcidAminic acid (see all 5)64-18-6transportersubstrate11101640
    Gamma Hydroxybutyric Acid4-Hydroxy-butanoic acid (see all 9)591-81-1transportersubstrate11101640
    Glyoxalate, Glyoxylate-- 298-12-4transportersubstrate11101640
    Lactic Acid-- 50-21-5transportersubstrate11101640
    Niacin3-Pyridinecarboxylic acid (see all 9)59-67-6transporter--16213084

    2 Novoseek inferred chemical compound relationships for SLC16A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 53.8 10 10329977 (2), 16116050 (2), 17502341 (2), 18056982 (1) (see all 5)
    glucose 33.4 3 15507505 (1), 16862226 (1), 16051672 (1)



    Find genes that share compounds with SLC16A3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC16A3 gene (6 alternative transcripts): 
    NM_001042422.2  NM_001042423.2  NM_001206950.1  NM_001206951.1  NM_001206952.1  NM_004207.3  

    Unigene Cluster for SLC16A3:

    Solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
    Hs.500761  [show with all ESTs]
    Unigene Representative Sequence: NM_001206950
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000584689 ENST00000583237 ENST00000581642 ENST00000582743(uc002keb.3)
    ENST00000583444 ENST00000584781 ENST00000578684 ENST00000577650 ENST00000578574
    ENST00000579572 ENST00000582715 ENST00000580098 ENST00000581287(uc002ked.3 uc021ufn.1 uc021ufo.1)
    ENST00000578522 ENST00000580189 ENST00000582946 ENST00000578810 ENST00000583025

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    Additional mRNA sequence: 

    AK223040.1 BC112267.1 BC112269.1 

    22 DOTS entries:

    DT.100820107  DT.100820110  DT.217836  DT.99938854  DT.95274984  DT.100820098  DT.100820096  DT.121002080 
    DT.121002060  DT.121002081  DT.95274992  DT.92469240  DT.100030909  DT.100820101  DT.100820104  DT.100820109 
    DT.121002014  DT.121002040  DT.121002079  DT.92469232  DT.92469250  DT.101987533 

    Selected AceView cDNA sequences (see all 384):

    BQ772642 AI650708 CA454606 CA454912 CA487968 BQ218116 BM547366 CA455180 
    BM980920 BQ944999 BX383845 AI073362 BM979822 BM708943 CA416989 CN480863 
    BU624294 AK127319 CF131519 CB146517 BM669454 BQ949661 BQ771574 CA489665 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
    SP1:        -     -     -                 -                                                         
    SP2:              -     -                 -                                                         
    SP3:                                      -                                                         
    SP4:                                      -                                                         
    SP5:                                      -                                                         


    ECgene alternative splicing isoforms for SLC16A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC16A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC16A3 Expression
    About this image


    SLC16A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 3 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
             Epiblast-like cells
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Smooth Muscle (Muscoskeletal System)
     
     Skeletal Muscle (Muscoskeletal System)
    SLC16A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC16A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500761

    UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427
    Tissue specificity: Highly expressed in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC16A3: 
              Neurotoxicity in human mouse rat
              Drug Transporters in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC16A3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc16a31 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 84.27(n)1
    89.87(a)1
      11 (84.73 cM)5
    808791  NM_001038653.11  NP_001033742.11 
     1209484805 
    chicken
    (Gallus gallus)
    Aves SLC16A31 solute carrier family 16, member 3 (monocarboxylic more 71.13(n)
    79.91(a)
      395383  NM_204663.1  NP_989994.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC16A36
    solute carrier family 16 (monocarboxylate transpor...
    78(a)
    1 ↔ 1
    2(117894163-117931758)
    African clawed frog
    (Xenopus laevis)
    Amphibia mct3-prov2 monocarboxylate transporter 74.46(n)    BC044330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.73372 Danio rerio similar to monocarboxylate transporter more 76.9(n)    BC045489.1 


    ENSEMBL Gene Tree for SLC16A3 (if available)
    TreeFam Gene Tree for SLC16A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC16A3 gene
    SLC16A42  SLC16A52  SLC16A112  SLC16A62  SLC16A82  SLC16A142  SLC16A72  SLC16A12  
    SLC16A122  SLC16A92  SLC16A132  
    Selected SIMAP similar genes for SLC16A3 using alignment to 11 protein entries:     MOT4_HUMAN (see all proteins) (see all similar genes):
    C21orf37    DOCK8    PFKFB3    SLC16A8    DPP9    SLC16A7
    AARSD1    IRF2    SLC16A1    SEPSECS    COQ5    TUBA1C
    ZNF114    ZNF799    GEMIN6    TM2D1    SLC16A11    SLC16A5

    Find genes that share paralogs with SLC16A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC16A3 (see all 518)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476833341,2
    --75584001(+) CTTCCC/TGCAGC 2 -- us2k10--------
    rs739998111,2
    C,F--75584002(+) TTCCCG/ACAGCT 2 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1424243161,2
    --75584230(+) CCCCCC/TGCCAC 2 -- us2k10--------
    rs72154471,2
    C,F,A,H--75584231(+) CCCCCG/ACCACC 2 -- us2k115Minor allele frequency- A:0.20NS EA NA CSA WA 1140
    rs749895971,2
    C,F--75584248(+) TGGGCC/TTTTCT 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1838774961,2
    --75584311(+) ATCCTC/TGGAGA 2 -- us2k10--------
    rs1431572571,2
    --75584341(+) GCTCTC/GGCCCC 2 -- us2k10--------
    rs1482415121,2
    --75584357(+) ACAGCA/GTCCTG 2 -- us2k10--------
    rs1115016941,2
    C,F--75584379(+) CTCCGG/AGTGAG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1503677261,2
    C--75584396(+) CAAGTA/GGCCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC16A3 (80186273 - 80219005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC16A3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv995451CNV Deletion20482838
    nsv2166CNV Insertion18451855
    nsv909208CNV Loss21882294
    nsv909210CNV Loss21882294
    dgv3354n71CNV Loss21882294
    dgv3353n71CNV Loss21882294
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    nsv833572CNV Loss17160897
    nsv909052CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC16A3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC16A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603877    OMIM disorders: --


    Find genes that share disorders with SLC16A3           About GenesLikeMe

    Genetic Association Database (GAD): SLC16A3
    Human Genome Epidemiology (HuGE) Navigator: SLC16A3 (3 documents)

    Export disorders for SLC16A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC16A3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SLC16A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PubMed id 9425115)1, 2, 3 Price N.T.... Halestrap A.P. (Biochem. J. 1998)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PubMed id 17502341)1, 9 Wang Q. and Morris M.E. (Drug Metab. Dispos. 2007)
    6. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. (PubMed id 12657613)1, 9 Philp N.J....Hjelmeland L.M. (amp 2003)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9123 HGNC: 10924 AceView: SLC16A3 Ensembl:ENSG00000141526 euGenes: HUgn9123
    ECgene: SLC16A3 H-InvDB: SLC16A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC16A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC16A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC16A3 gene:
    Search GeneIP for patents involving SLC16A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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