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GIFtS
-

SLC16A3 Gene

protein-coding GIFtS: 62
GCID: GC17P080186

solute carrier family 16, member 3 (monocarboxylic acid...

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)

Explore 4 diseases affiliated with
SLC16A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4)¹ ²		MCT-4²
MCT4¹ ² ³		MCT 3²
MCT3¹ ²		Monocarboxylate Transporter 3²
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3¹ ²		Monocarboxylate Transporter 4²
MCT 4² ³		Solute Carrier Family 16 Member 3³
MCT-3²

External Ids:	HGNC: 10924¹	Entrez Gene: 9123²	Ensembl: ENSG00000141526⁷	OMIM: 603877⁵	UniProtKB: O15427³

Export aliases for SLC16A3 gene to outside databases

Previous GC identifers: GC17P079025 GC17P082998 GC17P080716 GC17P080865 GC17P077780 GC17P075585

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC16A3:

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate

transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly

different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic

requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2

(SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 (PubMed

9425115)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427

Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many

monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and

the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

Gene Wiki entry for SLC16A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010663.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC16A3 gene promoter:
PPAR-alpha Pax-5 c-Myb LUN-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC16A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC16A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25

SLC16A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P080186: view genomic region (about GC identifiers)

Start:	80,186,273 bp from pter	End:	80,219,005 bp from pter
Size:	32,733 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427 (See protein sequence)

Recommended Name: Monocarboxylate transporter 4

Size: 465 amino acids; 49469 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Caution: Was initially assigned as monocarboxylate transporter 3 (MCT3) (PubMed:9425115). However, it was later shown

that it corresponds to monocarboxylate transporter 4 (MCT4)

Secondary accessions: B3KXG8 Q2M1P8

Explore the universe of human proteins at neXtProt for SLC16A3: NX_O15427

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15427

SLC16A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001035887.1 NP_001035888.1 NP_001193879.1 NP_001193880.1 NP_001193881.1 NP_004198.1

ENSEMBL proteins:

ENSP00000464625 ENSP00000462854 ENSP00000462405 ENSP00000463912 ENSP00000463063

ENSP00000464326 ENSP00000463880 ENSP00000463978 ENSP00000463508 ENSP00000464112

ENSP00000464381 ENSP00000463005 ENSP00000376152 ENSP00000376150

Reactome Protein details: O15427
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC16A3

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9425115
GO:0015629	actin cytoskeleton	IDA	--
GO:0016020	membrane	TAS	9425115

SLC16A3 for ontologies About GeneDecksing

SLC16A3 Antibody Products:

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Assay Products for SLC16A3:

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	Uscn ELISAs and CLIAs for SLC16A3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC16A3 for domains About GeneDecksing

4 InterPro domains/families:

IPR020846 MFS_dom

IPR004743 Monocarb_transpt

IPR011701 MFS

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry O15427

ProtoNet protein and cluster: O15427

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427

Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427

Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many

monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and

the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

Genatlas biochemistry entry for SLC16A3:

solute carrier family 16 (monocarboxylic acids transport) member 3,expressed only in the retinal pigment epithelium

miRNA Products:		miRTarBase miRNAs that target SLC16A3: hsa-mir-16 (MIRT001416)

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		hsa-miR-3673 hsa-miR-206 hsa-miR-1260b hsa-miR-1 hsa-miR-613 hsa-miR-1260
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008028	monocarboxylic acid transmembrane transporter activity	TAS	9425115
GO:0015293	symporter activity	IEA	--
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	IEA	--

SLC16A3 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for SLC16A3:

Decreased POU5F1-GFP protein e

Increased cell number in S and

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Bile salt and organic anion SLC transporters

Bile salt and organic anion SLC transporters

1.00

Proton-coupled monocarboxylate transport

0.33

Pyruvate metabolism

Pyruvate metabolism

1.00

Basigin interactions

Basigin interactions

1.00

Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 Reactome Pathways for SLC16A3 (see all 12)

	Hemostasis
	Pyruvate metabolism
	Bile salt and organic anion SLC transporters
	Metabolism
	The citric acid (TCA) cycle and respiratory electron transport

SLC16A3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC16A3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SLC16A3 (O15427³ ENSP00000376150⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BSG	P35613³, ENSP00000333769⁴	I2D: score=2 STRING: ENSP00000333769
SLC16A1	ENSP00000358640⁴	STRING: ENSP00000358640
SLC16A8	ENSP00000321735⁴	STRING: ENSP00000321735
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006090	pyruvate metabolic process	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0015711	organic anion transport	--	--
GO:0015718	monocarboxylic acid transport	TAS	9425115
GO:0044281	small molecule metabolic process	TAS	--

SLC16A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC16A3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC16A3

1 HMDB Compound for SLC16A3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Pyruvic acid	2-Oxopropanoate (see all 14)	127-17-3	--

10 DrugBank Compounds for SLC16A3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pyruvic acid	2-Oxopropanoate (see all 8)	127-17-3	target	--	16213084
Pyruvic acid	2-Oxopropanoate (see all 8)	127-17-3	transporter	substrate	16213084 11101640
3-Phenylpyruvic Acid	--	--	transporter	substrate	11101640
Acetoacetic Acid	--	541-50-4	transporter	substrate	11101640
Alpha-ketoisovalerate	2-Keto-3-methylbutyric acid (see all 9)	759-05-7	transporter	substrate	11101640
D-Lactic Acid	--	10326-41-7	transporter	substrate	11101640
Formic Acid	Aminic acid (see all 5)	64-18-6	transporter	substrate	11101640
Gamma Hydroxybutyric Acid	4-Hydroxy-butanoic acid (see all 9)	591-81-1	transporter	substrate	11101640
Glyoxalate, Glyoxylate	--	298-12-4	transporter	substrate	11101640
Lactic Acid	--	50-21-5	transporter	substrate	11101640
Oxamic Acid	--	471-47-6	transporter	substrate	11101640

2 Novoseek chemical compound relationships for SLC16A3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lactate	53.8	10	10329977 (2), 16116050 (2), 17502341 (2), 18056982 (1) (see all 5)
glucose	33.4	3	15507505 (1), 16862226 (1), 16051672 (1)

Search CenterWatch for drugs/clinical trials and news about SLC16A3 / MOT4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC16A3 gene (6 alternative transcripts):

NM_001042422.2 NM_001042423.2 NM_001206950.1 NM_001206951.1 NM_001206952.1 NM_004207.3

Unigene Cluster for SLC16A3:

Solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

Hs.500761 [show with all ESTs]

Unigene Representative Sequence: NM_001206950

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000584689 ENST00000583237 ENST00000581642 ENST00000582743(uc002keb.3)

ENST00000583444 ENST00000584781 ENST00000578684 ENST00000577650 ENST00000578574

ENST00000579572 ENST00000582715 ENST00000580098 ENST00000581287(uc002ked.3 uc021ufn.1 uc021ufo.1)

ENST00000578522 ENST00000580189 ENST00000582946 ENST00000578810 ENST00000583025

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		hsa-miR-3673 hsa-miR-206 hsa-miR-1260b hsa-miR-1 hsa-miR-613 hsa-miR-1260
		SwitchGear 3'UTR luciferase reporter plasmid: SLC16A3 3' UTR sequence

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Additional cDNA sequence:

AK223040.1 BC112267.1 BC112269.1

22 DOTS entries:

DT.100820107 DT.100820110 DT.217836 DT.99938854 DT.95274984 DT.100820098 DT.100820096 DT.121002080

DT.121002060 DT.121002081 DT.95274992 DT.92469240 DT.100030909 DT.100820101 DT.100820104 DT.100820109

DT.121002014 DT.121002040 DT.121002079 DT.92469232 DT.92469250 DT.101987533

24/384 AceView cDNA sequences (see all 384):

BG830150 BM669454 BM554409 CB146517 BU557126 BM547366 CA489665 BQ933551

BQ771574 BX342129 BM979822 BM981152 BG419169 AI699651 CD742655 CF128747

CA454148 BQ957311 CB528819 BF594416 BQ946224 BI826749 CA455179 BQ944999

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A3 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	^	9
SP1:			-		-		-						-
SP2:					-		-						-
SP3:													-
SP4:													-
SP5:													-

ECgene alternative splicing isoforms for SLC16A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC16A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SLC16A3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Epiblast-like cells (Reconstitution of mo...)

Primordial germ cell-like cells (Reconstitution of mo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC16A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC16A3

SOURCE GeneReport for Unigene cluster: Hs.500761

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427

Tissue specificity: Highly expressed in skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including SLC16A3:

Neurotoxicity in human mouse rat

Drug Transporters in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLC16A3 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC16A3¹	solute carrier family 16, member 3 (monocarboxylic more	71.13(n) 79.91(a)		395383 NM_204663.1 NP_989994.1
lizard (Anolis carolinensis)	Reptilia	SLC16A3⁶	--	78(a)	1 ↔ 1	2(117894163-117900504)
African clawed frog (Xenopus laevis)	Amphibia	mct3-prov²	monocarboxylate transporter	74.46(n)		BC044330.1
zebrafish (Danio rerio)	Actinopterygii	Dr.7337²	Danio rerio similar to monocarboxylate transporter more	76.9(n)		BC045489.1
fruit fly (Drosophila melanogaster)	Insecta	CG8271³	monocarboxylate porter	35(a)		48C5 --

ENSEMBL Gene Tree for SLC16A3 (if available)
TreeFam Gene Tree for SLC16A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC16A3 gene

SLC16A4² SLC16A5² SLC16A10² SLC16A11² SLC16A2² SLC16A6² SLC16A8² SLC16A14²

SLC16A7² SLC16A1² SLC16A12² SLC16A9² SLC16A13²

18/25 SIMAP similar genes for SLC16A3 using alignment to 11 protein entries: MOT4_HUMAN (see all proteins) (see all similar genes):

C21orf37 DOCK8 KIAA0101 PFKFB3 SLC16A8 SLC16A7

IRF2 SLC16A1 SEPSECS COQ5 TUBA1C GEMIN6

SLC16A11 SLC16A5 SLC16A9 ATF1 NCKAP1L CDK10

SLC16A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113941979^1,2		--	75585043(+)	`TCCACA/GGTGCC`	2	--	us2k¹		2	CSA	3
rs112121020^1,2	F,	--	75585073(+)	`TCCCTC/TCTCAG`	2	--	us2k¹		2	CSA	4
rs113528040^1,2	C,	--	75585174(+)	`CTGGGT/CGGGAG`	2	--	us2k¹		1	NA	2
rs73999813^1,2	C,	--	75585460(+)	`GTCCCG/CCAAGG`	2	--	us2k¹		2	WA	120
rs114967601^1,2	C,F,	--	75585676(+)	`CAACTA/CGACTC`	2	--	us2k¹		1	WA	118
rs75888222^1,2	C,F,	--	75585710(+)	`TTACTC/GCCTGG`	2	--	us2k¹		1	NA	120
rs113940830^1,2	C,	--	75586245(+)	`GCGCTC/TCGAGG`	2	--	int¹		3	NA WA	240
rs113728711^1,2		--	75587004(+)	`AGGGAG/CTGGGG`	2	--	int¹		1	CSA	2
rs62079460^1,2	C,F,	--	75587129(+)	`GGGACC/ACTCTC`	2	--	int¹		5	NA WA EA	362
rs11657694^1,2	H	--	75587242(+)	`CACGCC/ATCAGT`	2	--	int¹		4	NS EA	410

HapMap Linkage Disequilibrium report for SLC16A3 (80186273 - 80219005 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC16A3
1 CNV: 73078
Human Gene Mutation Database (HGMD): SLC16A3

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC16A3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC16A3 for disorders           About GeneDecksing

OMIM gene information: 603877    OMIM disorders: --

4 diseases for SLC16A3:    About MalaCards

atherosclerosis hypoxia retinitis thyroiditis

Human Genome Epidemiology (HuGE) Navigator: SLC16A3 (3 documents)

Export disorders for SLC16A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC16A3 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with SLC16A3)

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Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PubMed id 9425115)^{1, 2, 3} Price N.T.... Halestrap A.P. (1998)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PubMed id 17502341)^{1, 9} Wang Q. and Morris M.E. (2007)
Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. (PubMed id 12657613)^{1, 9} Philp N.J....Hjelmeland L.M. (2003)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Monocarboxylate transport in human corneal epithelium and cell lines. (PubMed id 20035863)¹ Vellonen K.S....Urtti A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9123	HGNC: 10924	AceView: SLC16A3	Ensembl:ENSG00000141526	euGenes: HUgn9123
ECgene: SLC16A3	H-InvDB: SLC16A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC16A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC16A3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC16A3 gene:
Search GeneIP for patents involving SLC16A3

GeneCards and IP:
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