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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC16A3 Gene

protein-coding   GIFtS: 65
GCID: GC17P080186

Solute Carrier Family 16 (Monocarboxylate Transporter),...

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 16 (Monocarboxylate Transporter), Member 31 2     MCT-42
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 31 2     MCT32
Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4)1 2     MCT 32
MCT42 3     Monocarboxylate Transporter 32
MCT 42 3     Monocarboxylate Transporter 42
MCT-32     Solute Carrier Family 16 Member 33

External Ids:    HGNC: 109241   Entrez Gene: 91232   Ensembl: ENSG000001415267   OMIM: 6038775   UniProtKB: O154273   

Export aliases for SLC16A3 gene to outside databases

Previous GC identifers: GC17P079025 GC17P082998 GC17P080716 GC17P080865 GC17P077780 GC17P075585


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC16A3 Gene:
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked
monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to
have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the
metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682)
and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998
(PubMed 9425115)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC16A3 Gene: 
SLC16A3 (solute carrier family 16 (monocarboxylate transporter), member 3) is a protein-coding gene. Diseases associated with SLC16A3 include hypoxia, and atherosclerosis, and among its related super-pathways are Transmembrane transport of small molecules and Pyruvate metabolism. GO annotations related to this gene include secondary active monocarboxylate transmembrane transporter activity and symporter activity. An important paralog of this gene is SLC16A4.

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

Gene Wiki entry for SLC16A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC16A3 gene promoter:
         PPAR-alpha   Pax-5   c-Myb   LUN-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC16A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC16A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

SLC16A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080186:  view genomic region     (about GC identifiers)

Start:
80,186,273 bp from pter      End:
80,219,005 bp from pter
Size:
32,733 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427 (See protein sequence)
Recommended Name: Monocarboxylate transporter 4  
Size: 465 amino acids; 49469 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Was initially assigned as monocarboxylate transporter 3 (MCT3) (PubMed:9425115). However, it was later
shown that it corresponds to monocarboxylate transporter 4 (MCT4)
Secondary accessions: B3KXG8 Q2M1P8

Explore the universe of human proteins at neXtProt for SLC16A3: NX_O15427

Explore proteomics data for SLC16A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15427

  • SLC16A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC16A3 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001035887.1  NP_001035888.1  NP_001193879.1  NP_001193880.1  NP_001193881.1  NP_004198.1  

    ENSEMBL proteins: 
     ENSP00000464625   ENSP00000462854   ENSP00000462405   ENSP00000463912   ENSP00000463063  
     ENSP00000464326   ENSP00000463880   ENSP00000463978   ENSP00000463508   ENSP00000464112  
     ENSP00000464381   ENSP00000463005   ENSP00000376152   ENSP00000376150  
    Reactome Protein details: O15427
    Human Recombinant Protein Products for SLC16A3: 
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    Cloud-Clone Corp. Proteins for SLC16A3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9425115
    GO:0015629actin cytoskeleton IDA--
    GO:0016020membrane TAS9425115
    GO:0016021integral to membrane ----

    SLC16A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 4 
    SLC16 family of monocarboxylate transporters

    4 InterPro protein domains:
     IPR020846 MFS_dom
     IPR004743 Monocarb_transpt
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O15427

    ProtoNet protein and cluster: O15427

    UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    SLC16A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOT4_HUMAN, O15427
    Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
    many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and
    isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

         Genatlas biochemistry entry for SLC16A3:
    solute carrier family 16 (monocarboxylic acids transport) member 3,expressed only in the retinal pigment
    epithelium

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008028monocarboxylic acid transmembrane transporter activity TAS9425115
    GO:0015293symporter activity IEA--
    GO:0015355secondary active monocarboxylate transmembrane transporter activity IEA--
         
    SLC16A3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLC16A3:
     Decreased POU5F1-GFP protein e  Increased cell number in S and  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC16A3 
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    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC16A3:
    hsa-miR-3673 hsa-miR-206 hsa-miR-1260b hsa-miR-1 hsa-miR-613 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC16A3 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Pyruvate metabolism
    Pyruvate metabolism0.60
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    3Bile salt and organic anion SLC transporters
    Bile salt and organic anion SLC transporters0.42
    Proton-coupled monocarboxylate transport0.33
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72
    5Platelet activation, signaling and aggregation
    Hemostasis0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/12        Reactome Pathways for SLC16A3 (see all 12)
        Hemostasis
    Pyruvate metabolism
    Bile salt and organic anion SLC transporters
    Metabolism
    The citric acid (TCA) cycle and respiratory electron transport



    SLC16A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC16A3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC16A3 (O154273 ENSP000003761504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BSGP356133, ENSP000003337694I2D: score=2 STRING: ENSP00000333769
    SLC16A1ENSP000003586404STRING: ENSP00000358640
    SLC16A8ENSP000003217354STRING: ENSP00000321735
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0007596blood coagulation TAS--
    GO:0015711organic anion transport ----
    GO:0015718monocarboxylic acid transport TAS9425115
    GO:0044237cellular metabolic process TAS--

    SLC16A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC16A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC16A3 (MOT4)

    1 HMDB Compound for SLC16A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    10/11 DrugBank Compounds for SLC16A3 (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16213084
    transportersubstrate16213084 11101640
    3-Phenylpyruvic Acid-- --transportersubstrate11101640
    Acetoacetic Acid-- 541-50-4transportersubstrate11101640
    Alpha-ketoisovalerate2-Keto-3-methylbutyric acid (see all 9)759-05-7transportersubstrate11101640
    D-Lactic Acid-- 10326-41-7transportersubstrate11101640
    Formic AcidAminic acid (see all 5)64-18-6transportersubstrate11101640
    Gamma Hydroxybutyric Acid4-Hydroxy-butanoic acid (see all 9)591-81-1transportersubstrate11101640
    Glyoxalate, Glyoxylate-- 298-12-4transportersubstrate11101640
    Lactic Acid-- 50-21-5transportersubstrate11101640
    Niacin3-Pyridinecarboxylic acid (see all 9)59-67-6transporter--16213084

    2 Novoseek inferred chemical compound relationships for SLC16A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactate 53.8 10 10329977 (2), 16116050 (2), 17502341 (2), 18056982 (1) (see all 5)
    glucose 33.4 3 15507505 (1), 16862226 (1), 16051672 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC16A3 / MOT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC16A3 gene (6 alternative transcripts): 
    NM_001042422.2  NM_001042423.2  NM_001206950.1  NM_001206951.1  NM_001206952.1  NM_004207.3  

    Unigene Cluster for SLC16A3:

    Solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
    Hs.500761  [show with all ESTs]
    Unigene Representative Sequence: NM_001206950
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000584689 ENST00000583237 ENST00000581642 ENST00000582743(uc002keb.3)
    ENST00000583444 ENST00000584781 ENST00000578684 ENST00000577650 ENST00000578574
    ENST00000579572 ENST00000582715 ENST00000580098 ENST00000581287(uc002ked.3 uc021ufn.1 uc021ufo.1)
    ENST00000578522 ENST00000580189 ENST00000582946 ENST00000578810 ENST00000583025

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    Additional mRNA sequence: 

    AK223040.1 BC112267.1 BC112269.1 

    22 DOTS entries:

    DT.100820107  DT.100820110  DT.217836  DT.99938854  DT.95274984  DT.100820098  DT.100820096  DT.121002080 
    DT.121002060  DT.121002081  DT.95274992  DT.92469240  DT.100030909  DT.100820101  DT.100820104  DT.100820109 
    DT.121002014  DT.121002040  DT.121002079  DT.92469232  DT.92469250  DT.101987533 

    24/384 AceView cDNA sequences (see all 384):

    CA454912 CD672418 CD742655 CF131433 CA416989 BQ949661 BU624294 BM669454 
    BM008962 CA489665 BQ933551 BM708943 BQ957311 BQ220143 CA454606 BI489993 
    BM980920 CR620431 CF131519 AI650708 BM554409 BX377134 BQ002036 CA455180 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
    SP1:        -     -     -                 -                                                         
    SP2:              -     -                 -                                                         
    SP3:                                      -                                                         
    SP4:                                      -                                                         
    SP5:                                      -                                                         


    ECgene alternative splicing isoforms for SLC16A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC16A3 expression in normal human tissues (normalized intensities)      SLC16A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC16A3 Expression
    About this image


    SLC16A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See SLC16A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC16A3

    SOURCE GeneReport for Unigene cluster: Hs.500761

    UniProtKB/Swiss-Prot: MOT4_HUMAN, O15427
    Tissue specificity: Highly expressed in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC16A3: 
              Neurotoxicity in human mouse rat
              Drug Transporters in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC16A3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc16a31 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 84.34(n)1
    89.87(a)1
      11 (84.73 cM)5
    808791  NM_001038653.11  NP_001033742.11 
     1209484805 
    chicken
    (Gallus gallus)
    Aves SLC16A31 solute carrier family 16, member 3 (monocarboxylic more 71.13(n)
    79.91(a)
      395383  NM_204663.1  NP_989994.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC16A36
    Uncharacterized protein
    77(a)
    1 ↔ 1
    2(117894163-117931758)
    African clawed frog
    (Xenopus laevis)
    Amphibia mct3-prov2 monocarboxylate transporter 74.46(n)    BC044330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.73372 Danio rerio similar to monocarboxylate transporter more 76.9(n)    BC045489.1 


    ENSEMBL Gene Tree for SLC16A3 (if available)
    TreeFam Gene Tree for SLC16A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC16A3 gene
    SLC16A42  SLC16A102  SLC16A52  SLC16A112  SLC16A22  SLC16A62  SLC16A82  SLC16A142  
    SLC16A72  SLC16A12  SLC16A122  SLC16A92  SLC16A132  
    18/28 SIMAP similar genes for SLC16A3 using alignment to 11 protein entries:     MOT4_HUMAN (see all proteins) (see all similar genes):
    C21orf37    DOCK8    KIAA0101    PFKFB3    SLC16A8    DPP9
    SLC16A7    AARSD1    IRF2    SLC16A1    SEPSECS    COQ5
    TUBA1C    ZNF114    ZNF799    GEMIN6    SLC16A11    SLC16A5

    SLC16A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 SNPs in SLC16A3 are shown (see all 518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476833341,2
    --75584001(+) CTTCCC/TGCAGC 2 -- us2k10--------
    rs739998111,2
    C,F--75584002(+) TTCCCG/ACAGCT 2 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1424243161,2
    --75584230(+) CCCCCC/TGCCAC 2 -- us2k10--------
    rs72154471,2
    C,F,A,H--75584231(+) CCCCCG/ACCACC 2 -- us2k115Minor allele frequency- A:0.20NS EA NA CSA WA 1140
    rs749895971,2
    C,F--75584248(+) TGGGCC/TTTTCT 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1838774961,2
    --75584311(+) ATCCTC/TGGAGA 2 -- us2k10--------
    rs1431572571,2
    --75584341(+) GCTCTC/GGCCCC 2 -- us2k10--------
    rs1482415121,2
    --75584357(+) ACAGCA/GTCCTG 2 -- us2k10--------
    rs1115016941,2
    C,F--75584379(+) CTCCGG/AGTGAG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1503677261,2
    C--75584396(+) CAAGTA/GGCCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC16A3 (80186273 - 80219005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for SLC16A3 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv995451CNV Deletion20482838
    nsv2166CNV Insertion18451855
    nsv909208CNV Loss21882294
    nsv909210CNV Loss21882294
    dgv3354n71CNV Loss21882294
    dgv3353n71CNV Loss21882294
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    nsv833572CNV Loss17160897
    nsv909052CNV Loss21882294


    Human Gene Mutation Database (HGMD): SLC16A3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603877    OMIM disorders: --

    4 diseases for SLC16A3:    About MalaCards
    hypoxia    atherosclerosis    retinitis    thyroiditis


    SLC16A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC16A3
    Human Genome Epidemiology (HuGE) Navigator: SLC16A3 (3 documents)

    Export disorders for SLC16A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC16A3 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with SLC16A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PubMed id 9425115)1, 2, 3 Price N.T.... Halestrap A.P. (1998)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PubMed id 17502341)1, 9 Wang Q. and Morris M.E. (2007)
    6. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. (PubMed id 12657613)1, 9 Philp N.J....Hjelmeland L.M. (2003)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9123 HGNC: 10924 AceView: SLC16A3 Ensembl:ENSG00000141526 euGenes: HUgn9123
    ECgene: SLC16A3 H-InvDB: SLC16A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC16A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC16A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC16A3 gene:
    Search GeneIP for patents involving SLC16A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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