Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC16A2 Gene

protein-coding   GIFtS: 62
GCID: GC0XP073640

Solute Carrier Family 16, Member 2 (Thyroid Hormone Transporter)

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
(Previous symbols: DXS128, AHDS, MRX22)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 16, Member 2 (Thyroid Hormone Transporter)1 2     Allan-Herndon-Dudley Syndrome1
DXS1281 2 5     Mental Retardation, X-Linked 221
XPCT2 3 5     Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 21
AHDS1 2     Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 2
(Putative Transporter)1
MRX221 2     Solute Carrier Family 16, Member 2 (Monocarboxylic Acid Transporter 8)1
Monocarboxylate Transporter 72 3     DXS128E2
MCT82 3     MCT72
MCT 72 3     Monocarboxylate Transporter 82
MCT 82 3     Solute Carrier Family 16 Member 23
X-Linked PEST-Containing Transporter2 3     

External Ids:    HGNC: 109231   Entrez Gene: 65672   Ensembl: ENSG000001471007   OMIM: 3000955   UniProtKB: P360213   

Export aliases for SLC16A2 gene to outside databases

Previous GC identifers: GC0XP069442 GC0XP070815 GC0XP071855 GC0XP072507 GC0XP073424 GC0XP073557 GC0XP067253


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC16A2 Gene:
This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded
protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine
(rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the
development of the central nervous system. Loss of function mutations in this gene are associated with
psychomotor retardation in males while females exhibit no neurological defects and more moderate
thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the
cause of Allan-Herndon-Dudley syndrome. (provided by RefSeq, Mar 2012)

GeneCards Summary for SLC16A2 Gene: 
SLC16A2 (solute carrier family 16, member 2 (thyroid hormone transporter)) is a protein-coding gene. Diseases associated with SLC16A2 include allan-herndon-dudley syndrome, and mct8 -specific thyroid hormone cell transporter deficiency. GO annotations related to this gene include monocarboxylic acid transmembrane transporter activity and transporter activity. An important paralog of this gene is SLC16A4.

UniProtKB/Swiss-Prot: MOT8_HUMAN, P36021
Function: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4),
triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr
(By similarity)

Gene Wiki entry for SLC16A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC16A2 gene promoter:
         Max1   STAT1   MyoD   STAT1beta   STAT1alpha   E2F-1   E2F   HFH-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC16A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC16A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13.2

SLC16A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP073640:  view genomic region     (about GC identifiers)

Start:
73,641,085 bp from pter      End:
73,753,752 bp from pter
Size:
112,668 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOT8_HUMAN, P36021 (See protein sequence)
Recommended Name: Monocarboxylate transporter 8  
Size: 539 amino acids; 59511 Da
Subunit: Homodimer
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Miscellaneous: Abnormal brain development associated with MCT8 deficiency may be the consequence of either
decreased or increased intracellular T3 concentrations
Sequence caution: Sequence=AAB60374.1; Type=Erroneous initiation; Sequence=AAB60375.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q7Z797

Explore the universe of human proteins at neXtProt for SLC16A2: NX_P36021

Explore proteomics data for SLC16A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36021

  • SLC16A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC16A2 Protein Expression
    REFSEQ proteins: NP_006508.2  
    ENSEMBL proteins: 
     ENSP00000465734   ENSP00000466213   ENSP00000276033  

    Human Recombinant Protein Products for SLC16A2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC16A2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC16A2
    GenScript Custom Purified and Recombinant Proteins Services for SLC16A2
    Novus Biologicals SLC16A2 Protein
    Novus Biologicals SLC16A2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC16A2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9425115
    GO:0016020membrane TAS9425115
    GO:0016021integral to membrane ----

    SLC16A2 for ontologies           About GeneDecksing



    SLC16A2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC16A2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC16A2
    GenScript Custom Superior Antibodies Services for SLC16A2
    Novus Biologicals SLC16A2 Antibody
    Abcam antibodies for SLC16A2
    Cloud-Clone Corp. Antibodies for SLC16A2 
    Search ThermoFisher Antibodies for SLC16A2
    LSBio Antibodies in human, mouse, rat for SLC16A2 

    Assay Products for SLC16A2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC16A2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC16A2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC16A2 
    Cloud-Clone Corp. CLIAs for SLC16A2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 8 
    SLC16 family of monocarboxylate transporters

    3 InterPro protein domains:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry P36021

    ProtoNet protein and cluster: P36021

    UniProtKB/Swiss-Prot: MOT8_HUMAN, P36021
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    SLC16A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOT8_HUMAN, P36021
    Function: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4),
    triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr
    (By similarity)

         Genatlas biochemistry entry for SLC16A2:
    solute carrier family 16,member A2,monocarboxylic acids transporter,67kDa,mediating movement of lactate and
    pyruvate across membranes

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS7981683
    GO:0008028monocarboxylic acid transmembrane transporter activity TAS9425115
    GO:0015293symporter activity IEA--
         
    SLC16A2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Slc16a2):
     homeostasis/metabolism  immune system  nervous system  no phenotypic analysis 

    SLC16A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC16A2: Slc16a2tm1Dgen Slc16a2tm1.1Sref

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC16A2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC16A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC16A2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC16A2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC16A2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC16A2 (see all 59):
    hsa-miR-576-3p hsa-miR-429 hsa-miR-29a hsa-miR-488 hsa-miR-449a hsa-miR-764 hsa-miR-374c hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC16A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC16A2
    Sirion Biotech Customized adenovirus for overexpression of SLC16A2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC16A2 (see all 5)
    OriGene ORF clones in mouse, rat for SLC16A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC16A2 (NM_006517)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC16A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A2
    Sirion Biotech Customized lentivirus for stable overexpression of SLC16A2 
                         Customized lentivirus expression plasmids for stable overexpression of SLC16A2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC16A2
    Search LifeMap BioReagents cell lines for SLC16A2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC16A2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC16A2 (P360213 ENSP000002760334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINA7P055433, ENSP000003293744I2D: score=1 STRING: ENSP00000329374
    THRAP108273, ENSP000002646374I2D: score=1 STRING: ENSP00000264637
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7981683
    GO:0015718monocarboxylic acid transport TAS9425115
    GO:0055085transmembrane transport ----

    SLC16A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC16A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC16A2 (MOT8)

    1 HMDB Compound for SLC16A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--

    6 DrugBank Compounds for SLC16A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Leucine(2S)-2-Amino-4-methylpentanoic acid (see all 16)61-90-5transportersubstrate12871948
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3transporterinhibitor12871948
    L-Tyrosine2-Amino-3-(p-hydroxyphenyl)propionic acid (see all 3)60-18-4transporterinhibitor12871948
    Levothyroxine(-)-Thyroxine (see all 13)51-48-9transporterinhibitor12871948
    Liotrix-- 8065-29-0transporterinhibitor12871948
    Pyruvic acid2-Oxopropanoate (see all 8)127-17-3target--16604139

    2 Novoseek inferred chemical compound relationships for SLC16A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triiodothyronine 70.7 20 15488219 (2), 17356046 (1), 19018842 (1), 19648159 (1) (see all 5)
    thyroxine 66.4 2 17899191 (1), 18334584 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC16A2 / MOT8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC16A2 gene: 
    NM_006517.4  

    Unigene Cluster for SLC16A2:

    Solute carrier family 16, member 2 (thyroid hormone transporter)
    Hs.75317  [show with all ESTs]
    Unigene Representative Sequence: U05315
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587091 ENST00000590447 ENST00000276033(uc004ebt.2 uc010nlr.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC16A2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC16A2 (see all 59):
    hsa-miR-576-3p hsa-miR-429 hsa-miR-29a hsa-miR-488 hsa-miR-449a hsa-miR-764 hsa-miR-374c hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmidSLC16A2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC16A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A2
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC16A2 (see all 5)
    OriGene ORF clones in mouse, rat for SLC16A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC16A2 (NM_006517)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC16A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A2
    Sirion Biotech Customized lentivirus for stable overexpression of SLC16A2 
                         Customized lentivirus expression plasmids for stable overexpression of SLC16A2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC16A2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC16A2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC16A2

    Additional mRNA sequence: 

    AB085789.1 AF055025.1 AK308542.1 U05315.1 

    3 DOTS entries:

    DT.87016902  DT.102826006  DT.91684266 

    24/114 AceView cDNA sequences (see all 114):

    AU125793 AW613567 T17350 AI654069 AB085789 AF055025 U05315 F05065 
    AI355911 CB105355 BU625930 AI192875 NM_006517 BQ015063 AW139037 AA436458 
    F02520 BG120651 AI498621 CA436438 BQ774063 AW137081 BM564786 F03730 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for SLC16A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC16A2 expression in normal human tissues (normalized intensities)      SLC16A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACATTTAA
    SLC16A2 Expression
    About this image


    SLC16A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Choroid Plexus
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier

    See SLC16A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC16A2

    SOURCE GeneReport for Unigene cluster: Hs.75317

    UniProtKB/Swiss-Prot: MOT8_HUMAN, P36021
    Tissue specificity: Highly expressed in liver and heart

        SABiosciences Expression via Pathway-Focused PCR Array including SLC16A2: 
              Drug Transporters in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC16A2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC16A2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC16A2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC16A2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc16a21 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 90.23(n)1
    94.81(a)1
      X (46.29 cM)5
    205021  NM_009197.21  NP_033223.21 
     1036974145 
    chicken
    (Gallus gallus)
    Aves SLC16A21 solute carrier family 16, member 2 (monocarboxylic more 70.46(n)
    67.81(a)
      428716  XM_426274.3  XP_426274.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC16A26
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343813.1(65638-82080)
    zebrafish
    (Danio rerio)
    Actinopterygii slc16a26
    solute carrier family 16 (monocarboxylic acid tran...
    56(a)
    1 ↔ 1
    14(1162309-1170206)
    fruit fly
    (Drosophila melanogaster)
    Insecta kar3 ommochrome biosynthesis monocarboxylic
    acid transporter
    39(a)   3 87C5   --


    ENSEMBL Gene Tree for SLC16A2 (if available)
    TreeFam Gene Tree for SLC16A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC16A2 gene
    SLC16A42  SLC16A32  SLC16A102  SLC16A52  SLC16A112  SLC16A62  SLC16A82  SLC16A142  
    SLC16A72  SLC16A12  SLC16A122  SLC16A92  SLC16A132  
    4 SIMAP similar genes for SLC16A2 using alignment to 2 protein entries:     MOT8_HUMAN (see all proteins):
    SLC16A10    SLC16A13    SLC16A7    SLC16A3

    SLC16A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1405 SNPs in SLC16A2 are shown (see all 1405)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0223484
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0223482 A V mis40--------
    VAR_0590564
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0590562 V M mis40--------
    VAR_0223504
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0223502 L P mis40--------
    VAR_0590594
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0590592 G R mis40--------
    VAR_0590544
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0590542 S F mis40--------
    VAR_0223494
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0223492 L P mis40--------
    VAR_0590574
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0590572 L W mis40--------
    VAR_0590604
    Monocarboxylate transporter 8 deficiency (MCT8 deficiency)4--see VAR_0590602 L P mis40--------
    rs66474761,2
    Cnon-pathogenic173649669(+) CGGAGC/TCTGAG 2 P S mis1 ese33Minor allele frequency- T:0.00NA CSA 3
    rs128491611,2
    C,Fnon-pathogenic173752584(+) ACCCCA/C/TAGCAA 2 P syn1 ese34NA WA CSA 4613

    HapMap Linkage Disequilibrium report for SLC16A2 (73641085 - 73753752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC16A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv424889CNV Insertion16902084
    esv1645631CNV Insertion17803354
    nsv507971CNV Insertion20534489
    nsv521472CNV Gain19592680


    Human Gene Mutation Database (HGMD): SLC16A2

    Locus Specific Mutation Databases (LSDB): SLC16A2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC16A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300095   
    OMIM disorders: 300523  
    UniProtKB/Swiss-Prot: MOT8_HUMAN, P36021
  • Monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM:300523]: Consists of a severe form of
    X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency
    can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular
    hormone transport. Affected patients are males with abnormal relative concentrations of three circulating
    iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central
    hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing.
    Heterozygous females had a milder thyroid phenotype and no neurological defects. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20 diseases for SLC16A2:    About MalaCards
    allan-herndon-dudley syndrome    mct8 -specific thyroid hormone cell transporter deficiency    paroxysmal dyskinesia    spastic quadriplegia
    familial partial lipodystrophy    quadriplegia    x-linked disease    pelizaeus-merzbacher disease
    lipodystrophy    thyroiditis    major depressive disorder    mental retardation, x-linked
    mental retardation    hypotonia    intellectual disability    hypothyroidism
    spasticity    cerebritis    retinitis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for SLC16A2:
    X-linked disease     Intellectual disability     Hypothyroidism

    SLC16A2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SLC16A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscle hypoplasia 85.3 3 17899191 (1)
    developmental delay 45.9 1 16417886 (1)
    mental retardation 43.7 6 19936787 (1), 16417886 (1), 19641107 (1)
    critically ill 38.8 6 19439506 (4), 19747372 (1), 16707210 (1)

    Genetic Association Database (GAD): SLC16A2
    Human Genome Epidemiology (HuGE) Navigator: SLC16A2 (2 documents)

    Export disorders for SLC16A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC16A2 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with SLC16A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. (PubMed id 15889350)1, 2, 3, 9 Schwartz C.E.... Stevenson R.E. (2005)
    2. A novel transmembrane transporter encoded by the XPCT gene in Xq13.2. (PubMed id 7981683)1, 2, 3, 9 Lafreniere R.G.... Willard H.F. (1994)
    3. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. (PubMed id 14661163)1, 2, 4, 9 Dumitrescu A.M.... Refetoff S. (2004)
    4. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. (PubMed id 12871948)1, 3, 7 Friesema E.C....Visser T.J. (2003)
    5. MCT8 mutation analysis and identification of the first female with Allan-Herndon-Dudley syndrome due to loss of MCT8 expression. (PubMed id 18398436)1, 2, 9 Frints S.G.... Kuss A.W. (2008)
    6. Prevalence and functional analysis of the S107P polymorphism (rs6647476) of the monocarboxylate transporter 8 (SLC16A2) gene in the male population of Northwest Spain (Galicia). (PubMed id 18710470)1, 4, 9 Lago-Leston R....Dominguez-Gerpe L. (2008)
    7. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. (PubMed id 15488219)1, 2, 9 Friesema E.C.H.... Visser T.J. (2004)
    8. Evidence for a homodimeric structure of human monocar boxylate transporter 8. (PubMed id 19797118)1, 2, 9 Visser W.E....Visser T.J. (2009)
    9. Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations. (PubMed id 18636565)1, 2, 9 Visser W.E....Visser T.J. (2009)
    10. Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. (PubMed id 18687783)1, 9 Roberts L.M....Zerangue N. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6567 HGNC: 10923 AceView: SLC16A2 Ensembl:ENSG00000147100 euGenes: HUgn6567
    ECgene: SLC16A2 H-InvDB: SLC16A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC16A2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC16A2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC16A2 gene:
    Search GeneIP for patents involving SLC16A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC16A2
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC16A2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SLC16A2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC16A2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC16A2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC16A2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC16A2   OriGene Custom Protein Services for SLC16A2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC16A2
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC16A2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC16A2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A2
     GenScript Custom Purified and Recombinant Proteins Services for SLC16A2 GenScript cDNA clones with any tag delivered in your preferred vector for SLC16A2
     GenScript Custom Assay Services for SLC16A2 GenScript Custom Superior Antibodies Services for SLC16A2
     GenScript Custom overexpressing Cell Line Services for SLC16A2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC16A2 promoter
     Search Chromatin IP Primers for SLC16A2
     RT2 qPCR Primer Assay in human, mouse, rat SLC16A2
     GNC Network for SLC16A2
     SABiosciences PCR Arrays including human, mouse, rat SLC16A2
     Search Tocris compounds for SLC16A2 (MOT8)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC16A2 antibodies
     SLC16A2 proteins
     SLC16A2 lysates
     Antibodies for SLC16A2
     See all of Abcam's Antibodies, Kits and Proteins for SLC16A2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC16A2
     Antibodies for SLC16A2
     ELISAs for SLC16A2
     CLIAs for SLC16A2
     Search LifeMap BioReagents cell lines for SLC16A2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A2
     SwitchGear 3'UTR luciferase reporter plasmids for SLC16A2
     SwitchGear Promoter luciferase reporter plasmids for SLC16A2
     Search ThermoFisher Antibodies for SLC16A2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC16A2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC16A2
    Customized:
     lentivirus for stable overexpression of SLC16A2
     lentivirus expression plasmids for stable overexpression of SLC16A2
     adenovirus for overexpression of SLC16A2
     LSBio Antibodies in human, mouse, rat for SLC16A2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC16A2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4