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Aliases for SLC16A14 Gene

Aliases for SLC16A14 Gene

  • Solute Carrier Family 16 Member 14 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 14 2 3
  • Monocarboxylic Acid Transporter 14 2 3
  • MCT 14 3 4
  • MCT14 3 4
  • Solute Carrier Family 16, Member 14 2
  • Monocarboxylate Transporter 14 3

External Ids for SLC16A14 Gene

Previous GeneCards Identifiers for SLC16A14 Gene

  • GC02M231102
  • GC02M230725
  • GC02M230607
  • GC02M230899
  • GC02M222739

Summaries for SLC16A14 Gene

GeneCards Summary for SLC16A14 Gene

SLC16A14 (Solute Carrier Family 16 Member 14) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A9.

UniProtKB/Swiss-Prot for SLC16A14 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A14 Gene

Genomics for SLC16A14 Gene

Regulatory Elements for SLC16A14 Gene

Enhancers for SLC16A14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G230599 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 -532.8 -532754 5.1 HDGF PKNOX1 FOXA2 CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 TRIP12 SLC16A14 SP140 SP110 SP140L GPR55 SP100 GC02P230588 LINC01907
GH02G230316 1.5 Ensembl ENCODE dbSUPER 9.8 -249.5 -249507 3.4 GATA2 FOS ZNF548 NFYC JUNB TBX21 KAT8 ZNF592 CREB3 NFIL3 SLC16A14 SP140L SP100 GC02M230318 GC02M230307
GH02G230755 1.2 Ensembl ENCODE 11.7 -688.7 -688655 4.7 PKNOX1 FOXA2 ZNF493 ZFP64 YBX1 BMI1 ZNF155 ZNF138 FOS RELB FBXO36 SLC16A14 CAB39 TEX44 TRIP12 RNU6-451P RNU6-268P GC02P230779
GH02G230008 1.1 Ensembl ENCODE 11.6 +60.6 60586 0.4 CTCF ZNF384 RAD21 FOSL1 ZNF316 ZSCAN5C ZNF143 SMC3 FOS NFE2 SLC16A14 GC02M230023 RNU6-1027P
GH02G230616 1.1 Ensembl ENCODE 9.6 -548.2 -548150 1.9 ELF3 PKNOX1 ARID4B DMAP1 ZSCAN9 ZNF48 ZNF2 RAD21 ZNF335 GTF3C2 RNU6-451P LOC101928816 SLC16A14 GC02P230588 LINC01907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A14 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000131634 899 1801 FOXA2 ZNF48 ZNF121 GLIS2 ZNF143 ZNF263 REST TBX21 KAT8 ZNF610

Genomic Location for SLC16A14 Gene

230,034,974 bp from pter
230,068,999 bp from pter
34,026 bases
Minus strand

Genomic View for SLC16A14 Gene

Genes around SLC16A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A14 Gene

Proteins for SLC16A14 Gene

  • Protein details for SLC16A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Monocarboxylate transporter 14
    Protein Accession:
    Secondary Accessions:
    • A8KA08
    • Q53R92
    • Q96NI7

    Protein attributes for SLC16A14 Gene

    510 amino acids
    Molecular mass:
    56254 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A14 Gene


neXtProt entry for SLC16A14 Gene

Post-translational modifications for SLC16A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A14 Gene

Domains & Families for SLC16A14 Gene

Gene Families for SLC16A14 Gene

Protein Domains for SLC16A14 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A14: view

Function for SLC16A14 Gene

Molecular function for SLC16A14 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Gene Ontology (GO) - Molecular Function for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A14: view
genes like me logo Genes that share phenotypes with SLC16A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A14

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A14 Gene

Localization for SLC16A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A14 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A14: view

Pathways & Interactions for SLC16A14 Gene

SuperPathways for SLC16A14 Gene

No Data Available

Interacting Proteins for SLC16A14 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q7RTX9-MOT14_HUMAN ENSP00000295190 for SLC16A14 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A14: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A14 Gene

Drugs & Compounds for SLC16A14 Gene

No Compound Related Data Available

Transcripts for SLC16A14 Gene

Unigene Clusters for SLC16A14 Gene

Solute carrier family 16, member 14 (monocarboxylic acid transporter 14):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: -
SP3: - -

Relevant External Links for SLC16A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC16A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A14 Gene

Protein tissue co-expression partners for SLC16A14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC16A14 Gene:


SOURCE GeneReport for Unigene cluster for SLC16A14 Gene:


Evidence on tissue expression from TISSUES for SLC16A14 Gene

  • Nervous system(4.8)
  • Lung(4)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SLC16A14: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A14 Gene

Orthologs for SLC16A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC16A14 34 35
  • 99.48 (n)
(Bos Taurus)
Mammalia SLC16A14 34 35
  • 85.1 (n)
(Rattus norvegicus)
Mammalia Slc16a14 34
  • 84.41 (n)
(Mus musculus)
Mammalia Slc16a14 34 16 35
  • 82.81 (n)
(Monodelphis domestica)
Mammalia SLC16A14 35
  • 82 (a)
(Canis familiaris)
Mammalia SLC16A14 34 35
  • 81.96 (n)
(Gallus gallus)
Aves SLC16A14 34 35
  • 72.51 (n)
(Anolis carolinensis)
Reptilia SLC16A14 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a14 34
  • 66.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13907 34
  • 47.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003206 34
  • 46.49 (n)
(Caenorhabditis elegans)
Secernentea pes-22 34
  • 43.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
Species where no ortholog for SLC16A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC16A14 Gene

Gene Tree for SLC16A14 (if available)
Gene Tree for SLC16A14 (if available)

Paralogs for SLC16A14 Gene

(7) SIMAP similar genes for SLC16A14 Gene using alignment to 6 proteins: Pseudogenes for SLC16A14 Gene

genes like me logo Genes that share paralogs with SLC16A14: view

Variants for SLC16A14 Gene

Sequence variations from dbSNP and Humsavar for SLC16A14 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000372846 -- 230,064,017(+) GCTTG(A/G)GCCTG intron-variant
rs1000413305 -- 230,050,531(+) CTGTT(A/G)TCGGG intron-variant
rs1000500895 -- 230,062,930(+) TTCCT(C/T)CTTCA intron-variant
rs1000541602 -- 230,053,086(+) ACAGG(G/T)GCTTG intron-variant
rs1000641746 -- 230,045,440(+) CTGTA(A/C)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A14 Gene

Variant ID Type Subtype PubMed ID
dgv164e55 CNV gain 17911159
dgv4179n100 CNV gain 25217958
dgv7330n54 CNV gain 21841781
esv3575337 CNV gain 25503493
esv3594584 CNV loss 21293372
esv3594585 CNV gain 21293372
esv3594594 CNV gain 21293372
esv3594595 CNV loss 21293372
nsv1008431 CNV gain 25217958
nsv460118 CNV gain 19166990
nsv584650 CNV gain 21841781

Variation tolerance for SLC16A14 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A14 Gene

Disorders for SLC16A14 Gene

Relevant External Links for SLC16A14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC16A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A14 Gene

Publications for SLC16A14 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap A.P. … Meredith D. (Pflugers Arch. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for SLC16A14 Gene

Sources for SLC16A14 Gene

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