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Aliases for SLC16A14 Gene

Aliases for SLC16A14 Gene

  • Solute Carrier Family 16 Member 14 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 14 2 3
  • Monocarboxylic Acid Transporter 14 2 3
  • MCT 14 3 4
  • MCT14 3 4
  • Solute Carrier Family 16, Member 14 2
  • Monocarboxylate Transporter 14 3

External Ids for SLC16A14 Gene

Previous GeneCards Identifiers for SLC16A14 Gene

  • GC02M231102
  • GC02M230725
  • GC02M230607
  • GC02M230899
  • GC02M222739

Summaries for SLC16A14 Gene

GeneCards Summary for SLC16A14 Gene

SLC16A14 (Solute Carrier Family 16 Member 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A9.

UniProtKB/Swiss-Prot for SLC16A14 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Additional gene information for SLC16A14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A14 Gene

Genomics for SLC16A14 Gene

GeneHancer (GH) Regulatory Elements for SLC16A14 Gene

Promoters and enhancers for SLC16A14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I230066 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.9 939 2.9 ZNF48 ZNF121 GLIS2 ZNF143 REST KAT8 ZNF610 NBN ZNF785 CTCF SLC16A14 GC02M230059 RNY4P19
GH02I230599 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10 -532.8 -532754 5.1 HDGF FOXA2 SMAD1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 IKZF2 SLC16A14 SP140 SP110 SP140L GPR55 SP100 GC02P230588 LINC01907
GH02I230755 Enhancer 1 Ensembl ENCODE 11.7 -688.7 -688654 4.7 PKNOX1 FOXA2 ZNF493 ZFP64 YBX1 ZNF155 ZNF213 ZNF138 ATF7 IKZF2 NCL FBXO36 SLC16A14 CAB39 LOC101928816 TEX44 RNU6-451P RNU6-268P GC02P230779
GH02I230008 Enhancer 0.9 Ensembl ENCODE 11.7 +60.6 60585 0.4 CTCF RB1 ZNF384 RAD21 FOSL1 ZNF316 ZSCAN5C ZNF143 SMC3 NFE2 SLC16A14 GC02M230023 RNU6-1027P FBXO36
GH02I230316 Enhancer 1 Ensembl ENCODE dbSUPER 9.9 -249.5 -249507 3.4 SRF ZNF687 CBFB EBF1 ELF1 DPF2 BCL11A IKZF1 MLLT1 ETV6 GC02M230318 SLC16A14 SP140L SP100 GC02M230307
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC16A14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC16A14 gene promoter:

Genomic Locations for SLC16A14 Gene

Genomic Locations for SLC16A14 Gene
chr2:230,034,974-230,068,999
(GRCh38/hg38)
Size:
34,026 bases
Orientation:
Minus strand
chr2:230,899,690-230,933,715
(GRCh37/hg19)

Genomic View for SLC16A14 Gene

Genes around SLC16A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A14 Gene

Proteins for SLC16A14 Gene

  • Protein details for SLC16A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX9-MOT14_HUMAN
    Recommended name:
    Monocarboxylate transporter 14
    Protein Accession:
    Q7RTX9
    Secondary Accessions:
    • A8KA08
    • Q53R92
    • Q96NI7

    Protein attributes for SLC16A14 Gene

    Size:
    510 amino acids
    Molecular mass:
    56254 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A14 Gene

Post-translational modifications for SLC16A14 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC16A14 Gene

Domains & Families for SLC16A14 Gene

Gene Families for SLC16A14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A14 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTX9

UniProtKB/Swiss-Prot:

MOT14_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A14: view

Function for SLC16A14 Gene

Molecular function for SLC16A14 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Phenotypes From GWAS Catalog for SLC16A14 Gene

Gene Ontology (GO) - Molecular Function for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A14: view
genes like me logo Genes that share phenotypes with SLC16A14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A14 Gene

Localization for SLC16A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A14 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A14: view

Pathways & Interactions for SLC16A14 Gene

SuperPathways for SLC16A14 Gene

No Data Available

Interacting Proteins for SLC16A14 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295190%0d%0a9606.ENSP00000286548%0d%0a9606.ENSP00000324740%0d%0a
Selected Interacting proteins: Q7RTX9-MOT14_HUMAN ENSP00000295190 for SLC16A14 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A14: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A14 Gene

Drugs & Compounds for SLC16A14 Gene

No Compound Related Data Available

Transcripts for SLC16A14 Gene

Unigene Clusters for SLC16A14 Gene

Solute carrier family 16, member 14 (monocarboxylic acid transporter 14):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for SLC16A14 Gene

GeneLoc Exon Structure for
SLC16A14
ECgene alternative splicing isoforms for
SLC16A14

Expression for SLC16A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A14 Gene



Protein tissue co-expression partners for SLC16A14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC16A14 Gene:

SLC16A14

SOURCE GeneReport for Unigene cluster for SLC16A14 Gene:

Hs.504317

Evidence on tissue expression from TISSUES for SLC16A14 Gene

  • Nervous system(4.8)
  • Lung(4)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SLC16A14: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A14 Gene

Orthologs for SLC16A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A14 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia SLC16A14 33 34
  • 85.1 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a14 33
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Slc16a14 33 16 34
  • 82.81 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A14 34
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A14 33 34
  • 81.96 (n)
chicken
(Gallus gallus)
Aves SLC16A14 33 34
  • 72.51 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A14 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a14 33
  • 66.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13907 33
  • 47.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003206 33
  • 46.49 (n)
worm
(Caenorhabditis elegans)
Secernentea pes-22 33
  • 43.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for SLC16A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC16A14 Gene

ENSEMBL:
Gene Tree for SLC16A14 (if available)
TreeFam:
Gene Tree for SLC16A14 (if available)

Paralogs for SLC16A14 Gene

Paralogs for SLC16A14 Gene

(7) SIMAP similar genes for SLC16A14 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SLC16A14 Gene

genes like me logo Genes that share paralogs with SLC16A14: view

Variants for SLC16A14 Gene

Sequence variations from dbSNP and Humsavar for SLC16A14 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000372846 -- 230,064,017(-) A/G intron_variant
rs1000413305 -- 230,050,531(-) A/G intron_variant
rs1000500895 -- 230,062,930(-) C/T intron_variant
rs1000541602 -- 230,053,086(-) T/G intron_variant
rs1000641746 -- 230,045,440(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A14 Gene

Variant ID Type Subtype PubMed ID
dgv164e55 CNV gain 17911159
dgv4179n100 CNV gain 25217958
dgv7330n54 CNV gain 21841781
esv3575337 CNV gain 25503493
esv3594584 CNV loss 21293372
esv3594585 CNV gain 21293372
esv3594594 CNV gain 21293372
esv3594595 CNV loss 21293372
nsv1008431 CNV gain 25217958
nsv460118 CNV gain 19166990
nsv584650 CNV gain 21841781

Variation tolerance for SLC16A14 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A14 Gene

Disorders for SLC16A14 Gene

Additional Disease Information for SLC16A14

No disorders were found for SLC16A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A14 Gene

Publications for SLC16A14 Gene

  1. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap AP … Meredith D (Pflugers Archiv : European journal of physiology 2004) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney. (PMID: 27364523) Roshanbin S … Fredriksson R (BMC neuroscience 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SLC16A14 Gene

Sources for SLC16A14 Gene

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