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Aliases for SLC16A14 Gene

Aliases for SLC16A14 Gene

  • Solute Carrier Family 16 Member 14 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 14 2 3
  • Monocarboxylic Acid Transporter 14 2 3
  • MCT 14 3 4
  • MCT14 3 4
  • Solute Carrier Family 16, Member 14 2
  • Monocarboxylate Transporter 14 3

External Ids for SLC16A14 Gene

Previous GeneCards Identifiers for SLC16A14 Gene

  • GC02M231102
  • GC02M230725
  • GC02M230607
  • GC02M230899
  • GC02M222739

Summaries for SLC16A14 Gene

GeneCards Summary for SLC16A14 Gene

SLC16A14 (Solute Carrier Family 16 Member 14) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A9.

UniProtKB/Swiss-Prot for SLC16A14 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A14 Gene

Genomics for SLC16A14 Gene

Regulatory Elements for SLC16A14 Gene

Enhancers for SLC16A14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F230755 0.6 Ensembl ENCODE 11.7 -688.7 -688655 4.7 PKNOX1 ZFP64 ZNF493 YBX1 ZNF155 ZNF138 FOS EGR2 ZNF202 ZNF680 FBXO36 SLC16A14 CAB39 RNU6-451P RNU6-268P GC02P230779
GH02F230008 0.9 Ensembl ENCODE 11.6 +60.4 60395 0.8 TBL1XR1 RAD21 ZNF143 ETV6 CREM THAP11 ZNF654 CEBPB REST TBX21 SLC16A14 GC02M230023 RNU6-1027P
GH02F230010 0.6 ENCODE 11.6 +57.1 57108 2.8 HDAC1 PKNOX1 CBX3 ATF1 GLIS2 CREM ZEB2 MBD2 ZNF589 KLF16 SLC16A14 GC02M230023 RNU6-1027P
GH02F230160 1.1 Ensembl ENCODE 11.5 -91.3 -91303 0.6 CTCF ZNF654 MAX ZNF384 REST RAD21 KAT8 SMC3 ZNF143 SLC16A14 SP140 SP110 RNU6-451P ENSG00000283451
GH02F230161 0.6 Ensembl 11.2 -92.4 -92403 0.4 SLC16A14 ENSG00000283451 SP140
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC16A14 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121215 899 2200 ELF3 ZNF48 ZSCAN9 RAD21 ZEB1 ZNF121 GLIS2 ZNF143 ZNF263 ZNF362

Genomic Location for SLC16A14 Gene

Chromosome:
2
Start:
230,034,974 bp from pter
End:
230,068,999 bp from pter
Size:
34,026 bases
Orientation:
Minus strand

Genomic View for SLC16A14 Gene

Genes around SLC16A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A14 Gene

Proteins for SLC16A14 Gene

  • Protein details for SLC16A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX9-MOT14_HUMAN
    Recommended name:
    Monocarboxylate transporter 14
    Protein Accession:
    Q7RTX9
    Secondary Accessions:
    • A8KA08
    • Q53R92
    • Q96NI7

    Protein attributes for SLC16A14 Gene

    Size:
    510 amino acids
    Molecular mass:
    56254 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A14 Gene

Post-translational modifications for SLC16A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A14 Gene

Domains & Families for SLC16A14 Gene

Gene Families for SLC16A14 Gene

Protein Domains for SLC16A14 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7RTX9

UniProtKB/Swiss-Prot:

MOT14_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A14: view

Function for SLC16A14 Gene

Molecular function for SLC16A14 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Gene Ontology (GO) - Molecular Function for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A14: view
genes like me logo Genes that share phenotypes with SLC16A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A14

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A14 Gene

Localization for SLC16A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A14 Gene COMPARTMENTS Subcellular localization image for SLC16A14 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC16A14: view

Pathways & Interactions for SLC16A14 Gene

SuperPathways for SLC16A14 Gene

No Data Available

Interacting Proteins for SLC16A14 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295190%0d%0a9606.ENSP00000290429%0d%0a
Selected Interacting proteins: ENSP00000295190 Q7RTX9-MOT14_HUMAN for SLC16A14 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A14: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A14 Gene

Transcripts for SLC16A14 Gene

Unigene Clusters for SLC16A14 Gene

Solute carrier family 16, member 14 (monocarboxylic acid transporter 14):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for SLC16A14 Gene

GeneLoc Exon Structure for
SLC16A14
ECgene alternative splicing isoforms for
SLC16A14

Expression for SLC16A14 Gene

mRNA expression in normal human tissues for SLC16A14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A14 Gene



Protein tissue co-expression partners for SLC16A14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC16A14 Gene:

SLC16A14

SOURCE GeneReport for Unigene cluster for SLC16A14 Gene:

Hs.504317
genes like me logo Genes that share expression patterns with SLC16A14: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC16A14 Gene

Orthologs for SLC16A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A14 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia SLC16A14 34 35
  • 85.1 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a14 34
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Slc16a14 34 16 35
  • 82.81 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A14 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A14 34 35
  • 81.96 (n)
chicken
(Gallus gallus)
Aves SLC16A14 34 35
  • 72.51 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A14 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a14 34
  • 66.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13907 34
  • 47.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003206 34
  • 46.49 (n)
worm
(Caenorhabditis elegans)
Secernentea pes-22 34
  • 43.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for SLC16A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC16A14 Gene

ENSEMBL:
Gene Tree for SLC16A14 (if available)
TreeFam:
Gene Tree for SLC16A14 (if available)

Paralogs for SLC16A14 Gene

(7) SIMAP similar genes for SLC16A14 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SLC16A14 Gene

genes like me logo Genes that share paralogs with SLC16A14: view

Variants for SLC16A14 Gene

Sequence variations from dbSNP and Humsavar for SLC16A14 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10169000 -- 230,056,820(+) AGTTA(C/T)GATTG intron-variant
rs10169385 -- 230,051,207(+) ccaag(C/T)tagag intron-variant, downstream-variant-500B
rs10169589 -- 230,051,387(+) aattt(A/C)taggc intron-variant, downstream-variant-500B
rs10173359 -- 230,052,636(+) AGGGA(A/G)AAAAT intron-variant
rs10179946 -- 230,047,615(+) CTGAC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A14 Gene

Variant ID Type Subtype PubMed ID
dgv164e55 CNV gain 17911159
dgv4179n100 CNV gain 25217958
dgv7330n54 CNV gain 21841781
esv3575337 CNV gain 25503493
esv3594584 CNV loss 21293372
esv3594585 CNV gain 21293372
esv3594594 CNV gain 21293372
esv3594595 CNV loss 21293372
nsv1008431 CNV gain 25217958
nsv460118 CNV gain 19166990
nsv584650 CNV gain 21841781

Variation tolerance for SLC16A14 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A14 Gene

Disorders for SLC16A14 Gene

Relevant External Links for SLC16A14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A14

No disorders were found for SLC16A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A14 Gene

Publications for SLC16A14 Gene

  1. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap A.P. … Meredith D. (Pflugers Arch. 2004) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for SLC16A14 Gene

Sources for SLC16A14 Gene

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