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Aliases for SLC16A13 Gene

Aliases for SLC16A13 Gene

  • Solute Carrier Family 16 Member 13 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 13 2 3
  • Monocarboxylic Acid Transporter 13 2 3
  • MCT 13 3 4
  • MCT13 3 4
  • Solute Carrier Family 16, Member 13 2
  • Monocarboxylate Transporter 13 3

External Ids for SLC16A13 Gene

Previous GeneCards Identifiers for SLC16A13 Gene

  • GC17P007140
  • GC17P006882
  • GC17P006883
  • GC17P006939

Summaries for SLC16A13 Gene

GeneCards Summary for SLC16A13 Gene

SLC16A13 (Solute Carrier Family 16 Member 13) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A13 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A13 Gene

Genomics for SLC16A13 Gene

Regulatory Elements for SLC16A13 Gene

Enhancers for SLC16A13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007171 1.2 Ensembl ENCODE 11.3 +137.6 137606 4.2 FOXA2 ZNF133 YBX1 GLI4 ZNF207 KLF7 ZNF548 PAF1 ZNF202 ZNF662 DVL2 NLGN2 NEURL4 SNORD10 ATP1B2 SNORA48 MIR324 ZBTB4 PER1 LOC100996842
GH17G007177 1 ENCODE 11.3 +141.8 141774 1.7 ATF1 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 ZNF263 SP3 SP5 SLC16A11 ACADVL DLG4 SLC16A13 ELP5 CTDNEP1 MIR324 DVL2 PHF23 GABARAP
GH17G006710 1.5 FANTOM5 Ensembl ENCODE 6 -323.6 -323555 3.8 ARID4B YBX1 ZNF48 YY1 TCF12 SLC30A9 GLIS2 ZNF207 ZNF143 PAF1 SLC13A5 ASGR1 ASGR2 LOC100996842 SLC16A13 SLC16A11 GC17M006685
GH17G007170 0.5 Ensembl 11.3 +135.0 135026 0.6 GATAD2A HLF CEBPG RBFOX2 SLC16A11 DLG4 ACADVL SLC16A13 CTDNEP1 ELP5 DVL2 PHF23 GABARAP MIR324
GH17G007169 0.4 Ensembl 11.3 +133.9 133926 0.8 RBFOX2 SLC16A11 ACADVL DLG4 SLC16A13 CLEC10A ELP5 CTDNEP1 DVL2 PHF23 GABARAP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A13 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090790 125 1601 HDGF PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for SLC16A13 Gene

Chromosome:
17
Start:
7,036,075 bp from pter
End:
7,040,121 bp from pter
Size:
4,047 bases
Orientation:
Plus strand

Genomic View for SLC16A13 Gene

Genes around SLC16A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A13 Gene

Proteins for SLC16A13 Gene

  • Protein details for SLC16A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY0-MOT13_HUMAN
    Recommended name:
    Monocarboxylate transporter 13
    Protein Accession:
    Q7RTY0
    Secondary Accessions:
    • A3KMG3
    • A5PKU5
    • Q2VP92

    Protein attributes for SLC16A13 Gene

    Size:
    426 amino acids
    Molecular mass:
    44992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A13 Gene

Post-translational modifications for SLC16A13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC16A13 Gene

Domains & Families for SLC16A13 Gene

Gene Families for SLC16A13 Gene

Protein Domains for SLC16A13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTY0

UniProtKB/Swiss-Prot:

MOT13_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A13: view

Function for SLC16A13 Gene

Molecular function for SLC16A13 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Gene Ontology (GO) - Molecular Function for SLC16A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A13: view
genes like me logo Genes that share phenotypes with SLC16A13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A13

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A13 Gene

Localization for SLC16A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A13 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A13 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC16A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA,IEA 24390345
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A13: view

Pathways & Interactions for SLC16A13 Gene

SuperPathways for SLC16A13 Gene

No Data Available

Interacting Proteins for SLC16A13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309751%0d%0a9606.ENSP00000349970%0d%0a
Selected Interacting proteins: ENSP00000309751 Q7RTY0-MOT13_HUMAN for SLC16A13 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC16A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A13: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A13 Gene

Drugs & Compounds for SLC16A13 Gene

No Compound Related Data Available

Transcripts for SLC16A13 Gene

mRNA/cDNA for SLC16A13 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC16A13 Gene

Solute carrier family 16, member 13 (monocarboxylic acid transporter 13):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A13 Gene

No ASD Table

Relevant External Links for SLC16A13 Gene

GeneLoc Exon Structure for
SLC16A13
ECgene alternative splicing isoforms for
SLC16A13

Expression for SLC16A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A13 Gene

This gene is overexpressed in Liver (x14.8) and Kidney - Cortex (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of SLC16A13 Gene:

SLC16A13

SOURCE GeneReport for Unigene cluster for SLC16A13 Gene:

Hs.448010
genes like me logo Genes that share expression patterns with SLC16A13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A13 Gene

Orthologs for SLC16A13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A13 34 35
  • 99.61 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a13 34
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Slc16a13 34 16 35
  • 88.18 (n)
cow
(Bos Taurus)
Mammalia SLC16A13 34 35
  • 87.72 (n)
dog
(Canis familiaris)
Mammalia SLC16A13 34 35
  • 86.12 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A13 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A13 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A13 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a13 34
  • 58.95 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793210 34
  • 57.99 (n)
SLC16A13 35
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for SLC16A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A13 Gene

ENSEMBL:
Gene Tree for SLC16A13 (if available)
TreeFam:
Gene Tree for SLC16A13 (if available)

Paralogs for SLC16A13 Gene

(9) SIMAP similar genes for SLC16A13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC16A13: view

Variants for SLC16A13 Gene

Sequence variations from dbSNP and Humsavar for SLC16A13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000378064 -- 7,037,293(+) GCCAA(G/T)ATCGC intron-variant
rs1000524384 -- 7,035,152(+) AGCCA(C/T)TGGTG upstream-variant-2KB
rs1000539158 -- 7,034,524(+) CAGAA(C/T)TTTGG upstream-variant-2KB
rs1000673284 -- 7,034,847(+) AAAGA(C/T)CCGAG upstream-variant-2KB
rs1000701209 -- 7,034,933(+) TCTTA(A/G)AAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC16A13 Gene

Variant ID Type Subtype PubMed ID
esv1405948 CNV deletion 17803354
esv2422288 CNV deletion 17116639
esv2665042 CNV deletion 23128226
esv2672389 CNV deletion 23128226
esv2715594 CNV deletion 23290073
esv3164902 CNV deletion 24192839
esv3554075 CNV deletion 23714750
nsv457659 CNV loss 19166990
nsv512475 CNV loss 21212237
nsv574322 CNV loss 21841781

Variation tolerance for SLC16A13 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A13 Gene

Disorders for SLC16A13 Gene

UniProtKB/Swiss-Prot

MOT13_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for SLC16A13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A13

No disorders were found for SLC16A13 Gene.

No data available for MalaCards and Genatlas for SLC16A13 Gene

Publications for SLC16A13 Gene

  1. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. (PMID: 24390345) . … Altshuler D. (Nature 2014) 3 4 64
  2. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap A.P. … Meredith D. (Pflugers Arch. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Genome-wide association study identifies three novel loci for type 2 diabetes. (PMID: 23945395) Hara K. … Kadowaki T. (Hum. Mol. Genet. 2014) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for SLC16A13 Gene

Sources for SLC16A13 Gene

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