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Aliases for SLC16A11 Gene

Aliases for SLC16A11 Gene

  • Solute Carrier Family 16, Member 11 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 11 2 3
  • Monocarboxylic Acid Transporter 11 2 3
  • MCT 11 3 4
  • MCT11 3 4
  • Solute Carrier Family 16 Member 11 4
  • Monocarboxylate Transporter 11 3

External Ids for SLC16A11 Gene

Summaries for SLC16A11 Gene

GeneCards Summary for SLC16A11 Gene

SLC16A11 (Solute Carrier Family 16, Member 11) is a Protein Coding gene. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC16A7.

UniProtKB/Swiss-Prot for SLC16A11 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A11 Gene

Genomics for SLC16A11 Gene

Genomic Location for SLC16A11 Gene

Start:
7,041,630 bp from pter
End:
7,043,923 bp from pter
Size:
2,294 bases
Orientation:
Minus strand

Genomic View for SLC16A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC16A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A11 Gene

Regulatory Elements for SLC16A11 Gene

Proteins for SLC16A11 Gene

  • Protein details for SLC16A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCK7-MOT11_HUMAN
    Recommended name:
    Monocarboxylate transporter 11
    Protein Accession:
    Q8NCK7
    Secondary Accessions:

    Protein attributes for SLC16A11 Gene

    Size:
    471 amino acids
    Molecular mass:
    47791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A11 Gene

Proteomics data for SLC16A11 Gene at MOPED

Post-translational modifications for SLC16A11 Gene

No Post-translational modifications

Other Protein References for SLC16A11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC16A11 Gene

Domains for SLC16A11 Gene

Gene Families for SLC16A11 Gene

Protein Domains for SLC16A11 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MOT11_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.:
    • Q8NCK7
genes like me logo Genes that share domains with SLC16A11: view

Function for SLC16A11 Gene

Molecular function for SLC16A11 Gene

UniProtKB/Swiss-Prot Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.

Gene Ontology (GO) - Molecular Function for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A11: view

Phenotypes for SLC16A11 Gene

genes like me logo Genes that share phenotypes with SLC16A11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC16A11 Gene

Localization for SLC16A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A11 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A11 Gene COMPARTMENTS Subcellular localization image for SLC16A11 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 24390345
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC16A11: view

Pathways for SLC16A11 Gene

SuperPathways for SLC16A11 Gene

No Data Available

Interacting Proteins for SLC16A11 Gene

Gene Ontology (GO) - Biological Process for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IDA 24390345
GO:0015718 monocarboxylic acid transport IBA --
GO:0034220 ion transmembrane transport IBA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC16A11: view

No data available for Pathways by source for SLC16A11 Gene

Transcripts for SLC16A11 Gene

mRNA/cDNA for SLC16A11 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC16A11 Gene

Solute carrier family 16, member 11 (monocarboxylic acid transporter 11):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A11 Gene

No ASD Table

Relevant External Links for SLC16A11 Gene

GeneLoc Exon Structure for
SLC16A11
ECgene alternative splicing isoforms for
SLC16A11

Expression for SLC16A11 Gene

mRNA expression in normal human tissues for SLC16A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A11 Gene

This gene is overexpressed in Thyroid (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC16A11 Gene

SOURCE GeneReport for Unigene cluster for SLC16A11 Gene Hs.336564

mRNA Expression by UniProt/SwissProt for SLC16A11 Gene

Q8NCK7-MOT11_HUMAN
Tissue specificity: Expressed in liver, salivary gland and thyroid.
genes like me logo Genes that share expressions with SLC16A11: view

Orthologs for SLC16A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A11 36
  • 99.08 (n)
  • 98.94 (a)
SLC16A11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC16A11 36
  • 84.43 (n)
  • 84.14 (a)
SLC16A11 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A11 36
  • 86.13 (n)
  • 87.25 (a)
SLC16A11 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a11 36
  • 84.12 (n)
  • 87.47 (a)
Slc16a11 16
Slc16a11 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A11 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a11 36
  • 83.82 (n)
  • 87.47 (a)
chicken
(Gallus gallus)
Aves SLC16A9 37
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
Species with no ortholog for SLC16A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC16A11 Gene

ENSEMBL:
Gene Tree for SLC16A11 (if available)
TreeFam:
Gene Tree for SLC16A11 (if available)

Paralogs for SLC16A11 Gene

Selected SIMAP similar genes for SLC16A11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC16A11: view

Variants for SLC16A11 Gene

Sequence variations from dbSNP and Humsavar for SLC16A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2271313 -- 7,043,128(-) GTGTT(A/G)GAGAG intron-variant
rs2292351 -- 7,043,602(-) AGCCA(C/G)AGGCT utr-variant-5-prime, intron-variant
rs2457689 -- 7,045,400(-) ATACA(A/T)AATAA upstream-variant-2KB
rs2920423 -- 7,041,165(-) agaca(A/G)aatct downstream-variant-500B
rs2920424 -- 7,041,163(-) acaaa(A/G)tctcc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC16A11 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907634 CNV Loss 21882294
nsv457659 CNV Loss 19166990
nsv482199 CNV Gain 20164927

Relevant External Links for SLC16A11 Gene

HapMap Linkage Disequilibrium report
SLC16A11

Disorders for SLC16A11 Gene

UniProtKB/Swiss-Prot

MOT11_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345). {ECO:0000269 PubMed:24390345}.

Relevant External Links for SLC16A11

Genetic Association Database (GAD)
SLC16A11
genes like me logo Genes that share disorders with SLC16A11: view

Publications for SLC16A11 Gene

  1. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. (PMID: 24390345) . … Altshuler D. (Nature 2014) 3 4
  2. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 49
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 49
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for SLC16A11 Gene

Sources for SLC16A11 Gene

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