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Aliases for SLC16A11 Gene

Aliases for SLC16A11 Gene

  • Solute Carrier Family 16 Member 11 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 11 2 3
  • Monocarboxylic Acid Transporter 11 2 3
  • MCT 11 3 4
  • MCT11 3 4
  • Solute Carrier Family 16, Member 11 2
  • Monocarboxylate Transporter 11 3

External Ids for SLC16A11 Gene

Previous GeneCards Identifiers for SLC16A11 Gene

  • GC17M006889
  • GC17M007145
  • GC17M006885
  • GC17M006944
  • GC17M006838

Summaries for SLC16A11 Gene

GeneCards Summary for SLC16A11 Gene

SLC16A11 (Solute Carrier Family 16 Member 11) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A13.

UniProtKB/Swiss-Prot for SLC16A11 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane (Probable). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A11 Gene

Genomics for SLC16A11 Gene

Regulatory Elements for SLC16A11 Gene

Enhancers for SLC16A11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007129 1.8 FANTOM5 Ensembl ENCODE 12.7 -87.7 -87701 5.0 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 CLEC10A SLC16A11 ASGR1 BCL6B RPL7AP64 EIF5A TRAPPC1 CD68 GABARAP SAT2
GH17F007112 1.6 FANTOM5 Ensembl ENCODE 11.5 -69.8 -69828 4.3 HDGF PKNOX1 MLX ARID4B GLI4 YBX1 DMAP1 ZNF48 YY1 ZNF121 ASGR2 LOC100996842 SLC16A11 RPL7AP64 CLEC10A ASGR1 XAF1 SLC13A5 CD68 GABARAP
GH17F007135 1.2 Ensembl ENCODE 12.7 -93.2 -93245 4.3 ELF3 ARID4B RAD21 RARA YY1 ZNF121 GLIS2 SCRT2 ZNF143 ZNF207 SLC16A11 RPL7AP64 ASGR2 BCL6B MIR324 CLEC10A KCNAB3 LOC105371512
GH17F007167 1.2 Ensembl ENCODE 12.3 -127.4 -127351 8.0 ZNF133 NFXL1 YBX1 GLI4 RAD21 YY1 ZNF354C ZNF207 KLF7 ZNF548 DVL2 SNORD10 CNTROB SNORA48 MIR324 MIR6883 CYB5D1 SLC16A11 KCTD11 ACADVL
GH17F007120 1.1 Ensembl ENCODE 11.9 -77.1 -77101 2.6 HDGF PKNOX1 ATF1 CBX3 ZNF121 CREM ZNF680 SP3 ZBTB2 ZBTB11 CLEC10A SLC16A11 ASGR1 BCL6B ACAP1 TNFSF12 TNFSF12-TNFSF13 TRAPPC1 ASGR2 LOC105371512
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A11 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001804751 600 401 INSM2 ZNF76 KLF17 GLIS2 EGR1 CREM EGR2 ZEB2 ZFP69B ZNF341
ENSR00001804750 1700 201 POLR2A HLF

Genomic Location for SLC16A11 Gene

Chromosome:
17
Start:
7,041,617 bp from pter
End:
7,044,400 bp from pter
Size:
2,784 bases
Orientation:
Minus strand

Genomic View for SLC16A11 Gene

Genes around SLC16A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A11 Gene

Proteins for SLC16A11 Gene

  • Protein details for SLC16A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCK7-MOT11_HUMAN
    Recommended name:
    Monocarboxylate transporter 11
    Protein Accession:
    Q8NCK7

    Protein attributes for SLC16A11 Gene

    Size:
    471 amino acids
    Molecular mass:
    47791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A11 Gene

Post-translational modifications for SLC16A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A11 Gene

No data available for DME Specific Peptides for SLC16A11 Gene

Domains & Families for SLC16A11 Gene

Gene Families for SLC16A11 Gene

Protein Domains for SLC16A11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCK7

UniProtKB/Swiss-Prot:

MOT11_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A11: view

Function for SLC16A11 Gene

Molecular function for SLC16A11 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane (Probable). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.

Gene Ontology (GO) - Molecular Function for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015129 lactate transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A11: view
genes like me logo Genes that share phenotypes with SLC16A11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC16A11 Gene

Localization for SLC16A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A11 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A11 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA,IDA 24390345
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A11: view

Pathways & Interactions for SLC16A11 Gene

SuperPathways for SLC16A11 Gene

No Data Available

Interacting Proteins for SLC16A11 Gene

Gene Ontology (GO) - Biological Process for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,IDA 24390345
GO:0006810 transport IEA --
GO:0035879 plasma membrane lactate transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A11: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A11 Gene

Transcripts for SLC16A11 Gene

mRNA/cDNA for SLC16A11 Gene

Unigene Clusters for SLC16A11 Gene

Solute carrier family 16, member 11 (monocarboxylic acid transporter 11):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A11 Gene

No ASD Table

Relevant External Links for SLC16A11 Gene

GeneLoc Exon Structure for
SLC16A11
ECgene alternative splicing isoforms for
SLC16A11

Expression for SLC16A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A11 Gene

This gene is overexpressed in Thyroid (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A11 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC16A11 Gene:

SLC16A11

SOURCE GeneReport for Unigene cluster for SLC16A11 Gene:

Hs.336564

mRNA Expression by UniProt/SwissProt for SLC16A11 Gene:

Q8NCK7-MOT11_HUMAN
Tissue specificity: Expressed in liver, salivary gland and thyroid.
genes like me logo Genes that share expression patterns with SLC16A11: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for SLC16A11 Gene

Orthologs for SLC16A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A11 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia SLC16A11 34 35
  • 86.13 (n)
cow
(Bos Taurus)
Mammalia SLC16A11 34 35
  • 84.43 (n)
mouse
(Mus musculus)
Mammalia Slc16a11 34 16 35
  • 84.12 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a11 34
  • 83.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A11 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A9 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for SLC16A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC16A11 Gene

ENSEMBL:
Gene Tree for SLC16A11 (if available)
TreeFam:
Gene Tree for SLC16A11 (if available)

Paralogs for SLC16A11 Gene

(7) SIMAP similar genes for SLC16A11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC16A11: view

Variants for SLC16A11 Gene

Sequence variations from dbSNP and Humsavar for SLC16A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111492515 -- 7,045,736(+) GCCAG(G/T)TTACA upstream-variant-2KB
rs114144953 -- 7,041,304(+) CAGGC(A/C)CATAG downstream-variant-500B
rs114454167 -- 7,043,420(+) GCGCA(A/G)CAGCC reference, synonymous-codon
rs114815410 -- 7,044,705(+) AACAC(A/G)ACTCC upstream-variant-2KB
rs115056404 -- 7,042,911(+) ACCCG(A/G)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A11 Gene

Variant ID Type Subtype PubMed ID
nsv574322 CNV loss 21841781
nsv482199 CNV gain 20164927
nsv457659 CNV loss 19166990
esv2422288 CNV deletion 17116639

Variation tolerance for SLC16A11 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A11 Gene

Human Gene Mutation Database (HGMD)
SLC16A11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A11 Gene

Disorders for SLC16A11 Gene

UniProtKB/Swiss-Prot

MOT11_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345). {ECO:0000269 PubMed:24390345}.

Relevant External Links for SLC16A11

Genetic Association Database (GAD)
SLC16A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A11

No disorders were found for SLC16A11 Gene.

No data available for MalaCards and Genatlas for SLC16A11 Gene

Publications for SLC16A11 Gene

  1. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. (PMID: 24390345) . … Altshuler D. (Nature 2014) 3 4 64
  2. Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression. (PMID: 26487785) Traurig M. … Bogardus C. (Diabetes 2016) 3 64
  3. Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4I+, KCNJ11, PPARI^, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes. (PMID: 25839936) Lara-Riegos J.C. … Menjivar M. (Gene 2015) 3 64
  4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 46 64
  5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 46 64

Products for SLC16A11 Gene

Sources for SLC16A11 Gene

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