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SLC16A11 Gene

protein-coding   GIFtS: 43
GCID: GC17M006944

Solute Carrier Family 16, Member 11

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
  Search for SLC16A11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 16, Member 111 2     MCT 112 3
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 111 2     Monocarboxylate Transporter 112
Monocarboxylic Acid Transporter 111 2     Solute Carrier Family 16 Member 113
MCT112 3     

External Ids:    HGNC: 230931   Entrez Gene: 1625152   Ensembl: ENSG000001743267   UniProtKB: Q8NCK73   

Export aliases for SLC16A11 gene to outside databases

Previous GC identifers: GC17M006889 GC17M007145 GC17M006885 GC17M006838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC16A11 Gene:
SLC16A11 (solute carrier family 16, member 11) is a protein-coding gene. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC16A4.

UniProtKB/Swiss-Prot: MOT11_HUMAN, Q8NCK7
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in
an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in
lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC16A11 gene promoter:
         SRF   USF1   Elk-1   Sp1   SRF (504 AA)   Bach2   USF2   USF-1:USF-2   SREBP-1a   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC16A11 promoter sequence
   Search Chromatin IP Primers for SLC16A11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC16A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

SLC16A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M006944:  view genomic region     (about GC identifiers)

Start:
6,944,949 bp from pter      End:
6,947,242 bp from pter
Size:
2,294 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MOT11_HUMAN, Q8NCK7 (See protein sequence)
Recommended Name: Monocarboxylate transporter 11  
Size: 471 amino acids; 47791 Da
Caution: It is uncertain whether Met-1 or Met-25 is the initiator

Explore the universe of human proteins at neXtProt for SLC16A11: NX_Q8NCK7

Explore proteomics data for SLC16A11 at MOPED


See SLC16A11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_699188.1  
ENSEMBL proteins: 
 ENSP00000310490   ENSP00000460927   ENSP00000394449  

SLC16A11 Human Recombinant Protein Products:

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SLC16A11 Assay Products:

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Cloud-Clone Corp. CLIAs for SLC16A11


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 11
SLC16 family of monocarboxylate transporters

3 InterPro protein domains:
 IPR011701 MFS
 IPR020846 MFS_dom
 IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q8NCK7

ProtoNet protein and cluster: Q8NCK7

UniProtKB/Swiss-Prot: MOT11_HUMAN, Q8NCK7
Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


SLC16A11 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MOT11_HUMAN, Q8NCK7
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of
many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in
an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in
lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015293symporter activity IEA--
     
SLC16A11 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for SLC16A11:
 Decreased homologous recombina  Increased S DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC16A11
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miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MOT11_HUMAN, Q8NCK7: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
endoplasmic reticulum1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IDA--
GO:0005886plasma membrane ----
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC16A11
Interactions:

    Search GeneGlobe Interaction Network for SLC16A11

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006629lipid metabolic process IDA--
GO:0055085transmembrane transport ----

SLC16A11 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC16A11 (MOT11)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLC16A11 gene: 
NM_153357.1  

Unigene Cluster for SLC16A11:

Solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
Hs.336564  [show with all ESTs]
Unigene Representative Sequence: AK074674
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000308009(uc002gei.1) ENST00000573338 ENST00000574600 ENST00000447225

miRNA
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Search for qRT-PCR Assays for microRNAs that regulate SLC16A11
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SLC16A11
Predesigned siRNA for gene silencing in human, mouse, rat SLC16A11
Clone
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OriGene ORF clones in mouse, rat for SLC16A11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SLC16A11 (NM_153357)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC16A11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A11
Primer
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  QuantiTect SYBR Green Assays in human, mouse, rat SLC16A11
  QuantiFast Probe-based Assays in human, mouse, rat SLC16A11

Additional mRNA sequence: 

AK074674.1 BC093860.1 BC093886.1 BC143369.1 

2 DOTS entries:

DT.40212537  DT.40129865 

13 AceView cDNA sequences:

NM_153357 AW297495 BX284081 BG674182 AK074674 AI742291 BG696982 R72227 
BU684425 AI088069 AI802877 AA890700 AA706593 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC16A11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SLC16A11 Expression
About this image


SLC16A11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Ovary (Reproductive System)
         Cumulus Cells Antral Follicle
SLC16A11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC16A11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.336564

UniProtKB/Swiss-Prot: MOT11_HUMAN, Q8NCK7
Tissue specificity: Expressed in liver, salivary gland and thyroid

    Custom PCR Arrays for SLC16A11
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QuantiFast Probe-based Assays in human, mouse, rat SLC16A11
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SLC16A11 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc16a111 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 84.12(n)1
87.47(a)1
  11 (42.99 cM)5
2168671  NM_153081.31  NP_694721.21 
 702127525 
chicken
(Gallus gallus)
Aves SLC16A96
monocarboxylate transporter 9
23(a)
many ↔ many
6(8593497-8611821)


ENSEMBL Gene Tree for SLC16A11 (if available)
TreeFam Gene Tree for SLC16A11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC16A11 gene
SLC16A42  SLC16A32  SLC16A52  SLC16A62  SLC16A82  SLC16A142  SLC16A72  SLC16A12  
SLC16A122  SLC16A92  SLC16A132  
7 SIMAP similar genes for SLC16A11 using alignment to 3 protein entries:     MOT11_HUMAN (see all proteins):
SLC16A13    SLC16A3    SLC16A8    SLC16A7    SLC16A12    SLC16A1
SLC16A5

SLC16A11 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC16A11 (see all 154)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1874220061,2
--6944555(+) ACAGGC/GTATAG 1 -- ds50010--------
rs1180651161,2
F--6944615(+) ATTTCC/GCTCAG 1 -- ds50011Minor allele frequency- G:0.02NA 120
rs1141449531,2
C,F--6944623(+) CAGGCC/ACATAG 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1918125461,2
--6944670(+) AGGTCA/TGGGAA 1 -- ds50010--------
rs75040251,2
C--6944676(+) GGGAAC/ATAGGG 1 -- ds50012Minor allele frequency- A:0.00NA 4
rs795248591,2
F--6944725(+) AACCCG/ACCCCC 1 -- ds50011Minor allele frequency- A:0.02WA 118
rs2016529991,2
--6945044(+) ACAGCA/GAGACT 2 S L mis10--------
rs2010748781,2
C--6945080(+) CCGTCT/GCTGGG 2 /E /A mis11Minor allele frequency- G:0.00EU 645
rs754935931,2,,4
C,F--6945087(+) TGGGGG/TAGGCG 2 T P mis13Minor allele frequency- T:0.01EA NA EU 3838
rs360004461,2
C,F--6945127(-) AGGGCG/ACTGCC 2 /A syn12Minor allele frequency- A:0.00NA 2876

HapMap Linkage Disequilibrium report for SLC16A11 (6944949 - 6947242 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SLC16A11:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422288CNV Deletion17116639
nsv457659CNV Loss19166990
nsv907634CNV Loss21882294
nsv482199CNV Gain20164927

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC16A11
DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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UniProtKB/Swiss-Prot: MOT11_HUMAN, Q8NCK7
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose
    homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese
    body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance,
    hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes,
    kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20%
    increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east
    Asian, while they are rare in European and African samples populations. These haplotypes probably derive from
    H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345)


  • SLC16A11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC16A11

    Export disorders for SLC16A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC16A11 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC16A11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. (PubMed id 24390345)1, 2  ....Altshuler D. (Nature 2014)
    2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    3. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PubMed id 12739169)1 Halestrap A.P. and Meredith D. (Pflugers Arch. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 162515 HGNC: 23093 AceView: SLC16A11 Ensembl:ENSG00000174326 euGenes: HUgn162515
    ECgene: SLC16A11 H-InvDB: SLC16A11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC16A11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC16A11 gene:
    Search GeneIP for patents involving SLC16A11

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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