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Aliases for SLC16A11 Gene

Aliases for SLC16A11 Gene

  • Solute Carrier Family 16 Member 11 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 11 2 3
  • Monocarboxylic Acid Transporter 11 2 3
  • MCT 11 3 4
  • MCT11 3 4
  • Solute Carrier Family 16, Member 11 2
  • Monocarboxylate Transporter 11 3

External Ids for SLC16A11 Gene

Previous GeneCards Identifiers for SLC16A11 Gene

  • GC17M006889
  • GC17M007145
  • GC17M006885
  • GC17M006944
  • GC17M006838

Summaries for SLC16A11 Gene

GeneCards Summary for SLC16A11 Gene

SLC16A11 (Solute Carrier Family 16 Member 11) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A13.

UniProtKB/Swiss-Prot for SLC16A11 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane (Probable). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.

Additional gene information for SLC16A11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A11 Gene

Genomics for SLC16A11 Gene

Regulatory Elements for SLC16A11 Gene

Enhancers for SLC16A11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H007130 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -87.8 -87812 4 HDGF PKNOX1 ARID4B ZNF143 ZNF207 ATF7 RUNX3 JUNB REST ZNF592 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68 GABARAP SAT2
GH17H007135 1.4 Ensembl ENCODE dbSUPER 12.7 -93.2 -93245 4.3 ELF3 ARID4B RAD21 RARA ZNF121 ZSCAN5C ZNF143 MIXL1 ZNF654 ZNF362 MIR324 SNORD10 DVL2 ENSG00000262089 KDM6B CNTROB SNORA48 WRAP53 SLC16A11 RPL7AP64
GH17H007113 1.5 Ensembl ENCODE dbSUPER 11.5 -70.4 -70369 3.1 HDGF FOXA2 MLX ARNT ARID4B YBX1 DMAP1 YY1 TCF12 ZNF207 DVL2 WRAP53 POLR2A NLGN2 CNTROB ELP5 SNORD10 ATP1B2 MIR324 SNORA48
GH17H007171 1.2 Ensembl ENCODE 12.3 -129.3 -129281 4.2 FOXA2 ZNF473 ZSCAN4 YBX1 NFXL1 GLI4 RAD21 ZNF354C ZNF207 KLF7 DVL2 CNTROB WRAP53 NLGN2 CYB5D1 NEURL4 LOC100996842 SNORD10 ELP5 DLG4
GH17H007120 1.2 Ensembl ENCODE dbSUPER 11.8 -76.8 -76834 1.7 HDGF PKNOX1 CEBPG BATF ZNF121 EED ETV6 RUNX3 IKZF2 NR2F1 SLC16A11 CLEC10A TNFSF12 TNFSF12-TNFSF13 TRAPPC1 ASGR2 LOC105371512
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC16A11 Gene

Genomic Locations for SLC16A11 Gene
chr17:7,041,617-7,044,400
(GRCh38/hg38)
Size:
2,784 bases
Orientation:
Minus strand
chr17:6,944,949-6,947,242
(GRCh37/hg19)

Genomic View for SLC16A11 Gene

Genes around SLC16A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A11 Gene

Proteins for SLC16A11 Gene

  • Protein details for SLC16A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCK7-MOT11_HUMAN
    Recommended name:
    Monocarboxylate transporter 11
    Protein Accession:
    Q8NCK7

    Protein attributes for SLC16A11 Gene

    Size:
    471 amino acids
    Molecular mass:
    47791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A11 Gene

Post-translational modifications for SLC16A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A11 Gene

No data available for DME Specific Peptides for SLC16A11 Gene

Domains & Families for SLC16A11 Gene

Gene Families for SLC16A11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCK7

UniProtKB/Swiss-Prot:

MOT11_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A11: view

Function for SLC16A11 Gene

Molecular function for SLC16A11 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane (Probable). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.

Phenotypes From GWAS Catalog for SLC16A11 Gene

Gene Ontology (GO) - Molecular Function for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28666119
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0050833 pyruvate transmembrane transporter activity IDA 28666119
genes like me logo Genes that share ontologies with SLC16A11: view
genes like me logo Genes that share phenotypes with SLC16A11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC16A11 Gene

Localization for SLC16A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A11 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A11 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA,IDA 24390345
GO:0005886 plasma membrane IEA,IDA 28666119
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC16A11 Gene

Pathways & Interactions for SLC16A11 Gene

SuperPathways for SLC16A11 Gene

No Data Available

Interacting Proteins for SLC16A11 Gene

Gene Ontology (GO) - Biological Process for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IDA,IEA 24390345
GO:0006810 transport IEA --
GO:0015718 monocarboxylic acid transport IBA --
GO:0055085 transmembrane transport IEA --
GO:1901475 pyruvate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A11: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A11 Gene

Drugs & Compounds for SLC16A11 Gene

No Compound Related Data Available

Transcripts for SLC16A11 Gene

mRNA/cDNA for SLC16A11 Gene

Unigene Clusters for SLC16A11 Gene

Solute carrier family 16, member 11 (monocarboxylic acid transporter 11):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A11 Gene

No ASD Table

Relevant External Links for SLC16A11 Gene

GeneLoc Exon Structure for
SLC16A11
ECgene alternative splicing isoforms for
SLC16A11

Expression for SLC16A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A11 Gene

This gene is overexpressed in Thyroid (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A11 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC16A11 Gene:

SLC16A11

SOURCE GeneReport for Unigene cluster for SLC16A11 Gene:

Hs.336564

mRNA Expression by UniProt/SwissProt for SLC16A11 Gene:

Q8NCK7-MOT11_HUMAN
Tissue specificity: Expressed in liver, salivary gland and thyroid.

Evidence on tissue expression from TISSUES for SLC16A11 Gene

  • Lung(4.1)
  • Heart(4)
genes like me logo Genes that share expression patterns with SLC16A11: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A11 Gene

Orthologs for SLC16A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A11 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia SLC16A11 33 34
  • 86.13 (n)
cow
(Bos Taurus)
Mammalia SLC16A11 33 34
  • 84.43 (n)
mouse
(Mus musculus)
Mammalia Slc16a11 33 16 34
  • 84.12 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a11 33
  • 83.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A11 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A9 34
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
OneToMany
Species where no ortholog for SLC16A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC16A11 Gene

ENSEMBL:
Gene Tree for SLC16A11 (if available)
TreeFam:
Gene Tree for SLC16A11 (if available)

Paralogs for SLC16A11 Gene

(7) SIMAP similar genes for SLC16A11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC16A11: view

Variants for SLC16A11 Gene

Sequence variations from dbSNP and Humsavar for SLC16A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000066497 -- 7,044,938(+) GATTA(C/T)GGGCG upstream-variant-2KB
rs1000138744 -- 7,042,369(+) CCCCG(C/G)TCTAA intron-variant, reference, missense
rs1000535247 -- 7,041,242(+) TATAG(A/G)TGTGT downstream-variant-500B
rs1001308159 -- 7,045,098(+) CTGGC(C/T)GATGT upstream-variant-2KB
rs1001736728 -- 7,046,367(+) CCACC(A/G)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC16A11 Gene

Variant ID Type Subtype PubMed ID
nsv574322 CNV loss 21841781
nsv482199 CNV gain 20164927
nsv457659 CNV loss 19166990
esv2422288 CNV deletion 17116639

Variation tolerance for SLC16A11 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A11 Gene

Human Gene Mutation Database (HGMD)
SLC16A11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A11 Gene

Disorders for SLC16A11 Gene

UniProtKB/Swiss-Prot

MOT11_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345). {ECO:0000269 PubMed:24390345}.

Relevant External Links for SLC16A11

Genetic Association Database (GAD)
SLC16A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A11

No disorders were found for SLC16A11 Gene.

No data available for MalaCards and Genatlas for SLC16A11 Gene

Publications for SLC16A11 Gene

  1. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. (PMID: 24390345) SIGMA Type 2 Diabetes Consortium … Altshuler D (Nature 2014) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. (PMID: 28666119) Rusu V … Lander ES (Cell 2017) 3 60
  4. Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression. (PMID: 26487785) Traurig M … Bogardus C (Diabetes 2016) 3 60
  5. Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes. (PMID: 25839936) Lara-Riegos JC … Menjivar M (Gene 2015) 3 60

Products for SLC16A11 Gene

Sources for SLC16A11 Gene

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