SLC16A10 Gene
protein-coding GIFtS : 55
GCID: GC06 P111454
solute carrier family 16, member 10 (aromatic amino acid... (Previous names: solute carrier family 16 (monocarboxylic acid transporters),... )
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Aliasesfor SLC16A10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Solute Carrier Family 16, Member 10 (Aromatic Amino Acid Transporter) 1 2 Solute Carrier Family 16 Member 102 3 TAT11 2 3 5 MCT 102 3 MCT101 2 3 T-Type Amino Acid Transporter 12 3 Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 101 2 PRO08132 Aromatic Amino Acid Transporter 12 3 Monocarboxylate Transporter 102
Export aliases for SLC16A10 gene to outside databases Previous GC identifers: GC06P111244 GC06P111431 GC06P111515 GC06P108979
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Summariesfor SLC16A10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SLC16A10 : SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.(supplied by OMIM, Apr 2004) UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71 Function : Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net effluxpathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) Gene Wiki entry for SLC16A10
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Genomic Viewsfor SLC16A10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC16A10 gene promoter: HFH-3 AML1a FOXD3 HNF-1A YY1 C/EBPalpha FOXI1 HNF-1 ZID Other transcription factors Search SABiosciences Chromatin IP Primers for SLC16A10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SLC16A10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q21-q22 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21-q22 SLC16A10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P111454: view genomic region
(about GC identifiers )
Start:
111,408,781 bp from pter
End:
111,545,145 bp from pter
Size:
136,365 bases
Orientation:
plus strand
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Proteinsfor SLC16A10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71 (See
protein sequence )Recommended Name: Monocarboxylate transporter 10 Size : 515 amino acids; 55493 Da
Subcellular location : Cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane (Bysimilarity)
Sequence caution : Sequence=AAH17968.1; Type=Erroneous initiation;
Secondary accessions : B3KWY0 Q6ZMG0 Q8WVI5Explore the universe of human proteins at neXtProt for SLC16A10: NX_Q8TF71 Post-translational modifications:
Not N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TF71 SLC16A10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_061063.2 ENSEMBL proteins: ENSP00000357844 ENSP00000399601 ENSP00000387501 ENSP00000357843 Reactome Protein details: Q8TF71 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
SLC16A10 for ontologies About GeneDecksing SLC16A10 Antibody Products: Assay Products for SLC16A10:
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Protein
Domains / Familiesfor SLC16A10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SLC16A10 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TF71 ProtoNet protein and cluster: Q8TF71
UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71 Similarity : Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family
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Functionfor SLC16A10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71 Function : Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net effluxpathway for aromatic amino acids in the basosolateral epithelial cells (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC16A10 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC16A10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC16A10 (NM_018593 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC16A10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC16A10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A10
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Pathways & Interactionsfor SLC16A10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Amino acid and oligopeptide SLC transporters 2 SLC-mediated transmembrane transport 3 Protein digestion and absorption
Pathway sources See GeneCards unified pathways Show all pathways 5
Reactome Pathways for SLC16A10 1
Kegg Pathway (Kegg details for SLC16A10) :
SLC16A10 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC16A10 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for SLC16A10 (Q8TF71 3 ENSP00000357844 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
SLC16A10 for ontologies About GeneDecksing
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Drugs & Compoundsfor SLC16A10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SLC16A10 1 HMDB Compound for SLC16A10 About this table 10/35 DrugBank Compounds for SLC16A10 (see all 35 ) About this table Search CenterWatch for drugs/clinical trials and news about SLC16A10 / MOT10
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Transcriptsfor SLC16A10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLC16A10 gene: NM_018593.4 Unigene Cluster for SLC16A10:
Solute carrier family 16, member 10 (aromatic amino acid transporter) Hs.591327 [show with all ESTs ] Unigene Representative Sequence: NM_018593 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000368851 (uc003pur.4 uc003pus.3 ) ENST00000419619 ENST00000439288 ENST00000465319 ENST00000368850 (uc003put.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC16A10 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC16A10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC16A10 (NM_018593 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC16A10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC16A10
Additional cDNA sequence: AB057445.1 AK126183.1 AK172789.1 BC017968.1 BC034031.1 BC066985.1
6 DOTS entries : DT.91733108 DT.311807
DT.40302867 DT.75106653 DT.99959363 DT.91687711 24/54 AceView cDNA sequences (see all 54 ):
AK126183 AI111187 BF059424 BF057228 AW196676 AA876069 BC034031 AI373734 AW058100 AA001776 BF196337 AI910470 AI221043 NM_018593 AB057445 AK172789 H95452 W32855 BX102123 AI242847 AF116652 BG498565 AL524602 W32409 GeneLoc Exon Structure
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Expression for SLC16A10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLC16A10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image SLC16A10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Brain Choroid Plexus Brain Neural Tube Metencephalon Neural Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SLC16A10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC16A10 SOURCE GeneReport for Unigene cluster: Hs.591327 UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71 Tissue specificity : Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart SABiosciences Custom PCR Arrays for SLC16A10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC16A10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat SLC16A10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC16A10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC16A10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A10
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Orthologsfor SLC16A10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SLC16A10 gene from 4/18 species (see all 18 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SLC16A101
solute carrier family 16, member 10 (aromatic amino more
73.13(n) 72.31(a)
 
421753 XM_419783.3 XP_419783.3
lizard (Anolis carolinensis)
Reptilia
SLC16A106 --
--
70(a) 30(a)
1 ↔ 1possible ortholog
1(192144562-192171512) 1(225466406-225473739)
zebrafish (Danio rerio)
Actinopterygii
slc16a101
solute carrier family 16, member 10 (aromatic amino more
65.22(n) 67.77(a)
 
566499 NM_001080028.1 NP_001073497.1
fruit fly (Drosophila melanogaster)
Insecta
kar1 , 3
ommochrome biosynthesis monocarboxylic acid transporter3 karmoisin1
45(a) 3 54.57(n) 1 46.42(a) 1
 
3 87C53 45883 1 NM_143768.3 1 NP_652025.2 1
ENSEMBL Gene Tree for SLC16A10 (if available)TreeFam Gene Tree for SLC16A10 (if available)
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Paralogsfor SLC16A10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SLC16A10 gene SLC16A4 2 SLC16A3 2 SLC16A5 2 SLC16A11 2 SLC16A2 2 SLC16A6 2 SLC16A8 2 SLC16A14 2 SLC16A7 2 SLC16A1 2 SLC16A12 2 SLC16A9 2 SLC16A13 2 9 SIMAP similar genes for SLC16A10 using alignment to 5 protein entries: MOT10_HUMAN (see all proteins ):SLC16A2 SLC16A12 SLC16A14 SLC16A3 SLC16A8 SLC16A9 SLC16A5 SLC16A1 SLC16A7
SLC16A10 for paralogs About GeneDecksing
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Genomic Variantsfor SLC16A10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More