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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC16A10 Gene

protein-coding   GIFtS: 56
GCID: GC06P111454

Solute Carrier Family 16 (Aromatic Amino Acid Transporter),...

(Previous names: solute carrier family 16 (monocarboxylic acid transporters),...)
  See related diseases
at
MalaCards
 

Aliases
for SLC16A10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Solute Carrier Family 16 (Aromatic Amino Acid Transporter), Member
101 2
     MCT 102 3
TAT12 3 5     T-Type Amino Acid Transporter 12 3
Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 101 2     PRO08132
Aromatic Amino Acid Transporter 12 3     Monocarboxylate Transporter 102
Solute Carrier Family 16 Member 102 3     Solute Carrier Family 16, Member 10 (Aromatic Amino Acid Transporter)2
MCT102 3     

External Ids:    HGNC: 170271   Entrez Gene: 1172472   Ensembl: ENSG000001123947   OMIM: 6075505   UniProtKB: Q8TF713   

Export aliases for SLC16A10 gene to outside databases

Previous GC identifers: GC06P111244 GC06P111431 GC06P111515 GC06P108979


Summaries
for SLC16A10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC16A10 Gene:
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent
transport of aromatic amino acids across the plasma membrane.(supplied by OMIM, Apr 2004)

GeneCards Summary for SLC16A10 Gene: 
SLC16A10 (solute carrier family 16 (aromatic amino acid transporter), member 10) is a protein-coding gene. Diseases associated with SLC16A10 include allan-herndon-dudley syndrome, and cystitis, and among its related super-pathways are Amino acid transport across the plasma membrane and Transmembrane transport of small molecules. An important paralog of this gene is SLC16A4.

UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71
Function: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux
pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity)

Gene Wiki entry for SLC16A10 Gene


Genomic Views
for SLC16A10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC16A10 gene promoter:
         HFH-3   AML1a   FOXD3   HNF-1A   YY1   C/EBPalpha   FOXI1   HNF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC16A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC16A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC16A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21-q22   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21-q22

SLC16A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P111454:  view genomic region     (about GC identifiers)

Start:
 111,408,781 bp from pter      End:
 111,552,397 bp from pter
Size:
 143,617 bases      Orientation:
 plus strand

Proteins
for SLC16A10 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71 (See protein sequence)
Recommended Name: Monocarboxylate transporter 10  
Size: 515 amino acids; 55493 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane (By
similarity)
Sequence caution: Sequence=AAH17968.1; Type=Erroneous initiation;
Secondary accessions: B3KWY0 Q6ZMG0 Q8WVI5

Explore the universe of human proteins at neXtProt for SLC16A10: NX_Q8TF71

Explore proteomics data for SLC16A10 at MOPED 

Post-translational modifications:

  • UniProtKB: Not N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF71

    • SLC16A10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC16A10 Protein Expression
    REFSEQ proteins: NP_061063.2  
    ENSEMBL proteins: 
     ENSP00000357844   ENSP00000387501   ENSP00000399601   ENSP00000357843  
    Reactome Protein details: Q8TF71
    Human Recombinant Protein Products for SLC16A10: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC16A10 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane TAS15918515

    SLC16A10 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for SLC16A10 
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    Protein Domains /
    Families
    for SLC16A10 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Monocarboxylate transporter 10 
    SLC16 family of monocarboxylate transporters

    3 InterPro protein domains:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8TF71

    ProtoNet protein and cluster: Q8TF71

    UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71
    Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


    SLC16A10 for domains           About GeneDecksing


    Function
    for SLC16A10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOT10_HUMAN, Q8TF71
    Function: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux
    pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity)

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC16A10 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC16A10 
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    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC16A10 (see all 15):
    hsa-miR-98 hsa-let-7d hsa-miR-513a-5p hsa-miR-27a hsa-miR-622 hsa-miR-202 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmid: SLC16A10 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for SLC16A10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC16A10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters0.63
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    		Amino acid transport across the plasma membrane0.63
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport0.50
    		Transmembrane transport of small molecules0.50
    3Protein digestion and absorption
    		Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SLC16A10
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Amino acid transport across the plasma membrane
    Transport of inorganic cations/anions and amino acids/oligopeptides


    1         Kegg Pathway  (Kegg details for SLC16A10):
        Protein digestion and absorption


    SLC16A10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC16A10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC16A10 (Q8TF713 ENSP000003578444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RACGAP1Q9H0H53, ENSP000003098714I2D: score=1 STRING: ENSP00000309871
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006865amino acid transport TAS--
    GO:0015801aromatic amino acid transport TAS15918515
    GO:0055085transmembrane transport TAS--

    SLC16A10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC16A10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC16A10 (MOT10)

    1 HMDB Compound for SLC16A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    10/35 DrugBank Compounds for SLC16A10 (see all 35)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-Phenylalanine-- 673-06-3transportersubstrate inhibitor11827462 11278508
    Glycine2-Aminoacetic acid (see all 4)56-40-6transportersubstrate inhibitor11827462 11278508
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0transportersubstrate inhibitor11827462 11278508
    L-Histidine(S)-4-(2-Amino-2-carboxyethyl)imidazole (see all 7)71-00-1transportersubstrate inhibitor11827462 11278508
    L-Leucine(2S)-2-Amino-4-methylpentanoic acid (see all 16)61-90-5transporterinhibitor11827462 11278508
    L-Lysine(S)-2,6-diaminohexanoic acid (see all 6)56-87-1transportersubstrate inhibitor11827462 11278508
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2transporterinhibitor11827462 11278508
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3transporterinhibitor11827462 11278508
    L-Tyrosine2-Amino-3-(p-hydroxyphenyl)propionic acid (see all 3)60-18-4transporterinhibitor11827462 11278508
    Lactic Acid-- 50-21-5transportersubstrate inhibitor11827462 11278508

    Search CenterWatch for drugs/clinical trials and news about SLC16A10 / MOT10

    Transcripts
    for SLC16A10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC16A10 gene: 
    NM_018593.4  

    Unigene Cluster for SLC16A10:

    Solute carrier family 16, member 10 (aromatic amino acid transporter)
    Hs.591327  [show with all ESTs]
    Unigene Representative Sequence: NM_018593
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368851(uc003pur.4 uc003pus.3) ENST00000439288 ENST00000465319
    ENST00000419619 ENST00000368850(uc003put.3)
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC16A10 (see all 15):
    hsa-miR-98 hsa-let-7d hsa-miR-513a-5p hsa-miR-27a hsa-miR-622 hsa-miR-202 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmid: SLC16A10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SLC16A10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC16A10
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC16A10
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    Additional mRNA sequence: 

    AB057445.1 AK126183.1 AK172789.1 BC017968.1 BC034031.1 BC066985.1 

    6 DOTS entries:

    DT.91733108  DT.311807  DT.40302867  DT.75106653  DT.99959363  DT.91687711 

    24/54 AceView cDNA sequences (see all 54):

    AA001776 AI910470 BF196337 AI221043 BF057228 AA876069 AK126183 BF059424 
    BC034031 AW196676 AI373734 AI111187 AW058100 N41980 BC066985 AW237016 
    BX102123 BM997859 D81852 BM354092 AI242847 CD251942 CK820059 W32855 

    GeneLoc Exon Structure


    Expression
    for SLC16A10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC16A10 expression in normal human tissues (normalized intensities)      SLC16A10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC16A10 Expression
    About this image


    SLC16A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             CyT49
             ESI-051   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Choroid Plexus
     
     Placenta (Extraembryonic Tissues)
             placenta   
     
     Chorion (Extraembryonic Tissues)
             Human Chorionic Mesenchymal Stromal Cells (HCMSC)   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See SLC16A10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC16A10

    SOURCE GeneReport for Unigene cluster: Hs.591327

    UniProtKB/Swiss-Prot: MOT10_HUMAN, Q8TF71
    Tissue specificity: Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart

        SABiosciences Custom PCR Arrays for SLC16A10
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A10

    Orthologs
    for SLC16A10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC16A10 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc16a101 , 5 solute carrier family 16 (monocarboxylic acid transporters), more1, 5 85.22(n)1
    84.96(a)1    		   10 (21.48 cM)5
    724721  NM_001114332.11  NP_001107804.11 
     400335355 
    chicken
    (Gallus gallus)    		 Aves SLC16A101 solute carrier family 16, member 10 (aromatic amino more 73.13(n)
    72.31(a)    		   421753  XM_419783.3  XP_419783.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC16A106
    		 Uncharacterized protein
    		 70(a)
    		 1 ↔ 1
    		 1(192144331-192171512)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc16a101 solute carrier family 16, member 10 (aromatic amino more 65.22(n)
    67.77(a)    		   566499  NM_001080028.1  NP_001073497.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kar1 , 3 ommochrome biosynthesis monocarboxylic
    acid transporter3
    karmoisin1    		 45(a)3
    54.57(n)1
    46.42(a)1    		   3 87C53
    458831  NM_143768.31  NP_652025.21 


    ENSEMBL Gene Tree for SLC16A10 (if available)
    TreeFam Gene Tree for SLC16A10 (if available)

    Paralogs
    for SLC16A10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC16A10 gene
    SLC16A42  SLC16A32  SLC16A52  SLC16A112  SLC16A22  SLC16A62  SLC16A82  SLC16A142  
    SLC16A72  SLC16A12  SLC16A122  SLC16A92  SLC16A132  
    9 SIMAP similar genes for SLC16A10 using alignment to 5 protein entries:     MOT10_HUMAN (see all proteins):
    SLC16A2    SLC16A12    SLC16A14    SLC16A3    SLC16A8    SLC16A9
    SLC16A5    SLC16A1    SLC16A7

    SLC16A10 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC16A10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2204 SNPs in SLC16A10 are shown (see all 2204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1856857281,2
    		--111406799(+) TGTGAC/TAGTTT 1 -- us2k10--------
    rs1905485411,2
    		--111406857(+) TAATGA/GGTATT 1 -- us2k10--------
    rs1930301811,2
    		--111406888(+) GGATTC/TGTCTA 1 -- us2k10--------
    rs1845508421,2
    		--111406957(+) AAGTAA/CCATTT 1 -- us2k10--------
    rs1885727491,2
    		--111407006(+) AGGTAC/TTGTGT 1 -- us2k10--------
    rs1455851421,2
    		--111407090(+) TACTAC/TGCATA 1 -- us2k10--------
    rs1381946891,2
    		C--111407128(+) CTTCAA/CCTCCA 1 -- us2k10--------
    rs119666641,2
    		C,F,H--111407204(+) tcattA/Gtttat 1 -- us2k1 tfbs34Minor allele frequency- G:0.02NS EA WA 392
    rs1428001011,2
    		C--111407225(+) ACTTAC/TATCAG 1 -- us2k10--------
    rs119617561,2
    		C,F,A,H--111407233(+) cagtaC/Ttgact 1 -- us2k15Minor allele frequency- T:0.02NS EA WA 534

    HapMap Linkage Disequilibrium report for SLC16A10 (111408781 - 111552397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SLC16A10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732574CNV Deletion23290073
    esv2661859CNV Deletion23128226
    nsv509149CNV Insertion20534489
    nsv5441CNV Insertion18451855
    nsv5440CNV Insertion18451855
    nsv886540CNV Loss21882294
    nsv886539CNV Gain21882294
    nsv886538CNV Gain21882294

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    Disorders / Diseases
    for SLC16A10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 607550    OMIM disorders: --

    5 diseases for SLC16A10:    About MalaCards
    allan-herndon-dudley syndrome    cystitis    transitional cell carcinoma    cerebritis
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for SLC16A10:
    Allan-Herndon-Dudley syndrome

    SLC16A10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC16A10
    Human Genome Epidemiology (HuGE) Navigator: SLC16A10 (2 documents)

    Export disorders for SLC16A10 gene to outside databases

    Publications
    for SLC16A10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC16A10 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SLC16A10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. (PubMed id 11827462)1, 2, 3, 7, 9 Kim D.K....Endou H. (2002)
    2. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. (PubMed id 11278508)1, 3, 7 Kim D.K....Endou H. (2001)
    3. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PubMed id 12739169)1, 9 Halestrap A.P. and Meredith D. (2004)
    4. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. (PubMed id 15918515)1, 9 Park S.Y....Kim D.K. (2005)
    5. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1 Kettunen J....Ripatti S. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodiff erentiation. (PubMed id 21486766)1 Chan S.Y....Kilby M.D. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. The thyroid hormone transporters MCT8 and MCT10 trans port the affinity-label N-bromoacetyl-[(125)I]T3 but are not modified by it. (PubMed id 21315799)1 Visser W.E....Visser T.J. (2011)

    External Searches for SLC16A10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SLC16A10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117247 HGNC: 17027 AceView: SLC16A10 Ensembl:ENSG00000112394 euGenes: HUgn117247
    ECgene: SLC16A10 Kegg: 117247 H-InvDB: SLC16A10

    Other Databases showing SLC16A10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC16A10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC16A10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC16A10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC16A10 gene:
    Search GeneIP for patents involving SLC16A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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