SLC16A10 Gene

Aliases
for SLC16A10 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC06P111244 GC06P111431 GC06P111515 GC06P108979

Summaries
for SLC16A10 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for SLC16A10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NT_025741.16  NC_018917.2  

SwitchGear Promoter luciferase reporter plasmid: SLC16A10 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC16A10

SLC16A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P111454:  view genomic region     (about GC identifiers)

Proteins
for SLC16A10 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for SLC16A10: NX_Q8TF71

Explore proteomics data for SLC16A10 at MOPED

Post-translational modifications: 

SLC16A10 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for SLC16A10
	GenScript Custom Purified and Recombinant Proteins Services for SLC16A10
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SLC16A10
	Search eBioscience for Proteins for SLC16A10
	Search GeneTex for Proteins for SLC16A10
	Search antibodies-online for proteins for SLC16A10
	antibodies-online peptides for SLC16A10

SLC16A10 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLC16A10
	Novus Biologicals SLC16A10 Antibody
	Abcam antibodies for SLC16A10
	Cloud-Clone Corp. Antibodies for SLC16A10
	Search ThermoFisher Antibodies for SLC16A10
	antibodies-online antibodies for SLC16A10 (9 products)

SLC16A10 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SLC16A10
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC16A10
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SLC16A10 Cloud-Clone Corp. CLIAs for SLC16A10
	Search eBioscience for ELISAs for SLC16A10
	antibodies-online kits for SLC16A10 (6 products)

Domains /
Families
for SLC16A10 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q8TF71

Find genes that share domains with SLC16A10           About GenesLikeMe

Function
for SLC16A10 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Phenotypes:
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc16a10):

genOway: Develop your customized and physiologically relevant rodent model for SLC16A10

miRNA Products:		miRTarBase miRNAs that target SLC16A10: hsa-mir-21-5p (MIRT002409)
		Block miRNA regulation of human, mouse, rat SLC16A10 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SLC16A10 (see all 15):
		hsa-miR-98 hsa-let-7d hsa-miR-513a-5p hsa-miR-27a hsa-miR-622 hsa-miR-202 hsa-let-7c hsa-let-7i
		SwitchGear 3'UTR luciferase reporter plasmid: SLC16A10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SLC16A10
		Predesigned siRNA for gene silencing in human, mouse, rat SLC16A10

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLC16A10

Clone Products:		OriGene clones in human, mouse for SLC16A10 (see all 8) OriGene ORF clones in mouse, rat for SLC16A10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLC16A10 (NM_018593)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC16A10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC16A10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC16A10
		Browse ESI BIO Cell Lines and PureStem Progenitors for SLC16A10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A10

Localization
for SLC16A10 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
extracellular	1
peroxisome	1

About this image

Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for SLC16A10 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for SLC16A10 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	SLC-mediated transmembrane transport 0.47 Transport of inorganic cations/anions and amino acids/oligopeptides 0.38 Transmembrane transport of small molecules 0.47 Amino acid transport across the plasma membrane 0.32
2	Thyroid hormone signaling pathway	Thyroid hormone signaling pathway
3	Protein digestion and absorption	Protein digestion and absorption

1 Reactome Pathway for SLC16A10

Amino acid transport across the plasma membrane

2 Kegg Pathways  (Kegg details for SLC16A10)

	Thyroid hormone signaling pathway
	Protein digestion and absorption

Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for SLC16A10 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for SLC16A10 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for SLC16A10 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC16A10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Blood (Hematopoietic System)    fully expand to see all 3 entries
T-Cytotoxic Cells Peripheral Blood
Brain (Nervous System)    fully expand to see all 2 entries
Choroid Plexus Progenitor Cells Choroid Plexus
Choroid Plexus
Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
Human embryonic stem cells (family)

Primer Products:		OriGene qPCR primer pairs and template standards for SLC16A10 OriGene qSTAR qPCR primer pairs in human, mouse for SLC16A10
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SLC16A10
		QuantiTect SYBR Green Assays in human, mouse, rat SLC16A10
		QuantiFast Probe-based Assays in human, mouse, rat SLC16A10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC16A10

Orthologs
for SLC16A10 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for SLC16A10 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for SLC16A10 gene

SLC16A2²  

9 SIMAP similar genes for SLC16A10 using alignment to 5 protein entries:     MOT10_HUMAN (see all proteins):

SLC16A2    SLC16A12    SLC16A14    SLC16A3    SLC16A8    SLC16A9

SLC16A5    SLC16A1    SLC16A7

Find genes that share paralogs with SLC16A10           About GenesLikeMe

Genomic Variants
for SLC16A10 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for SLC16A10 (see all 2204)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1856857281,2		--	111406799(+)	TGTGAC/TAGTTT	1	--	us2k1		0	--	--	--	--
rs1905485411,2		--	111406857(+)	TAATGA/GGTATT	1	--	us2k1		0	--	--	--	--
rs1930301811,2		--	111406888(+)	GGATTC/TGTCTA	1	--	us2k1		0	--	--	--	--
rs1845508421,2		--	111406957(+)	AAGTAA/CCATTT	1	--	us2k1		0	--	--	--	--
rs1885727491,2		--	111407006(+)	AGGTAC/TTGTGT	1	--	us2k1		0	--	--	--	--
rs1455851421,2		--	111407090(+)	TACTAC/TGCATA	1	--	us2k1		0	--	--	--	--
rs1381946891,2	C	--	111407128(+)	CTTCAA/CCTCCA	1	--	us2k1		0	--	--	--	--
rs119666641,2	C,F,H	--	111407204(+)	tcattA/Gtttat	1	--	us2k1 tfbs3		4		NS EA WA	392
rs1428001011,2	C	--	111407225(+)	ACTTAC/TATCAG	1	--	us2k1		0	--	--	--	--
rs119617561,2	C,F,A,H	--	111407233(+)	cagtaC/Ttgact	1	--	us2k1		5		NS EA WA	534

HapMap Linkage Disequilibrium report for SLC16A10 (111408781 - 111552397 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for SLC16A10:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2732574	CNV	Deletion	23290073
esv2661859	CNV	Deletion	23128226
nsv509149	CNV	Insertion	20534489
nsv5441	CNV	Insertion	18451855
nsv5440	CNV	Insertion	18451855
nsv886540	CNV	Loss	21882294
nsv886539	CNV	Gain	21882294
nsv886538	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SLC16A10

DNA2.0 Custom Variant and Variant Library Synthesis for SLC16A10

Disorders / Diseases
for SLC16A10 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for SLC16A10 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC16A10 gene, integrated from 10 sources (see all 20): (articles sorted by number of sources associating them with SLC16A10)

Utopia: connect your pdf to the dynamic world of online information

1. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. (PubMed id 11827462)^{1, 2, 3, 7, 9} Kim D.K.... Endou H. (Genomics 2002)
2. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. (PubMed id 11278508)^{1, 3, 7} Kim D.K....Endou H. (J. Biol. Chem. 2001)
3. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PubMed id 12739169)^{1, 9} Halestrap A.P. and Meredith D. (Pflugers Arch. 2004)
4. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. (PubMed id 15918515)^{1, 9} Park S.Y.... Kim D.K. (Arch. Pharm. Res. 2005)
5. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)¹ Kettunen J....Ripatti S. (Nat. Genet. 2012)
6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
8. The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation. (PubMed id 21486766)¹ Chan S.Y....Kilby M.D. (J. Physiol. (Lond.) 2011)
9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
10. The thyroid hormone transporters MCT8 and MCT10 transport the affinity-label N-bromoacetyl-[(125)I]T3 but are not modified by it. (PubMed id 21315799)¹ Visser W.E....Visser T.J. (Mol. Cell. Endocrinol. 2011)

External Searches for SLC16A10 gene

Genome Databases showing SLC16A10 gene

Other Databases showing SLC16A10 gene

Specialized Databases showing SLC16A10 gene

Products
for SLC16A10 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section