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Aliases for SLC16A10 Gene

Aliases for SLC16A10 Gene

  • Solute Carrier Family 16 Member 10 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 10 2 3
  • Solute Carrier Family 16 (Aromatic Amino Acid Transporter), Member 10 2 3
  • Aromatic Amino Acid Transporter 1 3 4
  • T-Type Amino Acid Transporter 1 3 4
  • MCT 10 3 4
  • MCT10 3 4
  • TAT1 3 4
  • Solute Carrier Family 16, Member 10 (Aromatic Amino Acid Transporter) 3
  • Monocarboxylate Transporter 10 3
  • PRO0813 3

External Ids for SLC16A10 Gene

Previous GeneCards Identifiers for SLC16A10 Gene

  • GC06P111244
  • GC06P111431
  • GC06P111454
  • GC06P111515
  • GC06P108979

Summaries for SLC16A10 Gene

Entrez Gene Summary for SLC16A10 Gene

  • SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC16A10 Gene

SLC16A10 (Solute Carrier Family 16 Member 10) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC16A2.

UniProtKB/Swiss-Prot for SLC16A10 Gene

  • Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).

Gene Wiki entry for SLC16A10 Gene

Additional gene information for SLC16A10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A10 Gene

Genomics for SLC16A10 Gene

Regulatory Elements for SLC16A10 Gene

Enhancers for SLC16A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H111113 1.4 FANTOM5 Ensembl ENCODE 17.1 +26.5 26477 1 MAZ RNF2 MAFG REST BMI1 ZNF316 MAFF ZNF341 BCL6B EMSY SLC16A10 MFSD4B AMD1 REV3L TRAF3IP2 RNU6-960P ENSG00000231046
GH06H111238 1.2 FANTOM5 Ensembl ENCODE 17.2 +151.1 151098 0 MAFG NR3C1 FOSL1 JUND ZNF316 MAFF FOS NFE2 EMSY MAFK SLC16A10 REV3L TRAF3IP2-AS1 ENSG00000230177 AMD1 TRAF3IP2 ENSG00000231046 RNU6-960P
GH06H111239 1.1 FANTOM5 Ensembl ENCODE 18.5 +151.9 151948 0 FOSL1 PKNOX1 SPI1 SLC16A10 REV3L MFSD4B TRAF3IP2-AS1 AMD1 TRAF3IP2 ENSG00000231046 RNU6-960P
GH06H111405 1.5 FANTOM5 Ensembl ENCODE 10.6 +319.2 319228 1 HDGF PKNOX1 BMI1 BATF RARA ZNF143 ATF7 ETV6 RUNX3 CREM REV3L TRAF3IP2-AS1 ENSG00000230177 SLC16A10 ENSG00000255389 TRAF3IP2 MFSD4B BRD7P4 REV3L-IT1
GH06H111086 1.3 FANTOM5 ENCODE 10.4 +0.4 437 2 ARNT ARID4B ZNF2 GLIS2 RUNX3 SP3 SP5 REST PPARG MAFF SLC16A10 MFSD4B AMD1 REV3L GC06M111092
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC16A10 on UCSC Golden Path with GeneCards custom track

Promoters for SLC16A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201111 397 1801 ARNT ARID4B ZNF2 GLIS2 RUNX3 SP3 SP5 REST PPARG MAFF

Genomic Location for SLC16A10 Gene

Chromosome:
6
Start:
111,087,503 bp from pter
End:
111,231,194 bp from pter
Size:
143,692 bases
Orientation:
Plus strand

Genomic View for SLC16A10 Gene

Genes around SLC16A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A10 Gene

Proteins for SLC16A10 Gene

  • Protein details for SLC16A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF71-MOT10_HUMAN
    Recommended name:
    Monocarboxylate transporter 10
    Protein Accession:
    Q8TF71
    Secondary Accessions:
    • B3KWY0
    • Q6ZMG0
    • Q8WVI5

    Protein attributes for SLC16A10 Gene

    Size:
    515 amino acids
    Molecular mass:
    55493 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17968.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC16A10 Gene

Post-translational modifications for SLC16A10 Gene

Other Protein References for SLC16A10 Gene

No data available for DME Specific Peptides for SLC16A10 Gene

Domains & Families for SLC16A10 Gene

Gene Families for SLC16A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TF71

UniProtKB/Swiss-Prot:

MOT10_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A10: view

Function for SLC16A10 Gene

Molecular function for SLC16A10 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).

Phenotypes From GWAS Catalog for SLC16A10 Gene

Gene Ontology (GO) - Molecular Function for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015173 aromatic amino acid transmembrane transporter activity IEA --
GO:0015349 thyroid hormone transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A10: view
genes like me logo Genes that share phenotypes with SLC16A10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A10

CRISPR Products

miRNA for SLC16A10 Gene

miRTarBase miRNAs that target SLC16A10

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC16A10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A10 Gene

Localization for SLC16A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A10 Gene

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A10 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
GO:0016323 basolateral plasma membrane TAS 15918515
genes like me logo Genes that share ontologies with SLC16A10: view

Pathways & Interactions for SLC16A10 Gene

genes like me logo Genes that share pathways with SLC16A10: view

Gene Ontology (GO) - Biological Process for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport IEA --
GO:0006865 amino acid transport TAS --
GO:0015718 monocarboxylic acid transport IEA --
GO:0015801 aromatic amino acid transport IEA,TAS 15918515
genes like me logo Genes that share ontologies with SLC16A10: view

No data available for SIGNOR curated interactions for SLC16A10 Gene

Drugs & Compounds for SLC16A10 Gene

(35) Drugs for SLC16A10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Droxidopa Approved, Investigational Pharma Transporter, inhibitor 33
Levodopa Approved Pharma Agonist, Transporter, inhibitor 406
Liotrix Approved Pharma Transporter, inhibitor 0
cystine Approved Nutra Transporter, inhibitor 0
Glutamic Acid Approved Nutra Full agonist, Agonist, Transporter, substrate, inhibitor 236

(1) Additional Compounds for SLC16A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC16A10: view

Transcripts for SLC16A10 Gene

Unigene Clusters for SLC16A10 Gene

Solute carrier family 16, member 10 (aromatic amino acid transporter):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC16A10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A10 Gene

No ASD Table

Relevant External Links for SLC16A10 Gene

GeneLoc Exon Structure for
SLC16A10
ECgene alternative splicing isoforms for
SLC16A10

Expression for SLC16A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A10 Gene

This gene is overexpressed in Muscle - Skeletal (x17.2) and Pancreas (x6.2).

Protein differential expression in normal tissues from HIPED for SLC16A10 Gene

This gene is overexpressed in Pancreas (28.4), Fetal Liver (13.9), Fetal ovary (9.5), and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC16A10 Gene



Protein tissue co-expression partners for SLC16A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC16A10 Gene:

SLC16A10

SOURCE GeneReport for Unigene cluster for SLC16A10 Gene:

Hs.591327

mRNA Expression by UniProt/SwissProt for SLC16A10 Gene:

Q8TF71-MOT10_HUMAN
Tissue specificity: Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.

Evidence on tissue expression from TISSUES for SLC16A10 Gene

  • Liver(4.2)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with SLC16A10: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A10 Gene

Orthologs for SLC16A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A10 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia SLC16A10 33 34
  • 89.82 (n)
dog
(Canis familiaris)
Mammalia SLC16A10 33 34
  • 89.72 (n)
mouse
(Mus musculus)
Mammalia Slc16a10 33 16 34
  • 85.03 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a10 33
  • 84.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A10 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC16A10 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A10 33 34
  • 75.69 (n)
lizard
(Anolis carolinensis)
Reptilia SLC16A10 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a10 33
  • 69.39 (n)
zebrafish
(Danio rerio)
Actinopterygii slc16a10 33 34
  • 67.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta kar 35 33 34
  • 54.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007743 33
  • 52.74 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y19D10A.12 33
  • 43.15 (n)
mct-1 34
  • 13 (a)
ManyToMany
mct-2 34
  • 13 (a)
ManyToMany
mct-3 34
  • 11 (a)
ManyToMany
mct-5 34
  • 10 (a)
ManyToMany
mct-6 34
  • 10 (a)
ManyToMany
mct-4 34
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3504 34
  • 15 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
-- 34
  • 12 (a)
ManyToMany
CSA.4076 34
  • 4 (a)
ManyToMany
Species where no ortholog for SLC16A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC16A10 Gene

ENSEMBL:
Gene Tree for SLC16A10 (if available)
TreeFam:
Gene Tree for SLC16A10 (if available)

Paralogs for SLC16A10 Gene

Paralogs for SLC16A10 Gene

(9) SIMAP similar genes for SLC16A10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC16A10: view

Variants for SLC16A10 Gene

Sequence variations from dbSNP and Humsavar for SLC16A10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000044223 -- 111,189,289(+) AAGTA(C/T)ATCCT intron-variant
rs1000054502 -- 111,104,498(+) AATAC(A/C)TTTTG intron-variant
rs1000063743 -- 111,131,579(+) ATACC(A/G)GGCAC intron-variant
rs1000110723 -- 111,185,352(+) TACAC(C/G)AAAGA intron-variant
rs1000130359 -- 111,097,511(+) GTTTC(A/G)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A10 Gene

Variant ID Type Subtype PubMed ID
esv2661859 CNV deletion 23128226
esv2732574 CNV deletion 23290073
esv3431181 CNV duplication 20981092
esv3610375 CNV loss 21293372
nsv1020627 CNV gain 25217958
nsv1028349 CNV gain 25217958
nsv1128270 CNV deletion 24896259
nsv480856 CNV novel sequence insertion 20440878
nsv509149 CNV insertion 20534489
nsv5440 CNV insertion 18451855
nsv5441 CNV insertion 18451855
nsv604517 CNV gain 21841781

Variation tolerance for SLC16A10 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A10 Gene

Disorders for SLC16A10 Gene

Relevant External Links for SLC16A10

Genetic Association Database (GAD)
SLC16A10
Human Genome Epidemiology (HuGE) Navigator
SLC16A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A10

No disorders were found for SLC16A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A10 Gene

Publications for SLC16A10 Gene

  1. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. (PMID: 11827462) Kim DK … Endou H (Genomics 2002) 2 3 4 22 25 60
  2. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. (PMID: 11278508) Kim DK … Endou H (The Journal of biological chemistry 2001) 2 3 25 60
  3. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. (PMID: 15918515) Park SY … Kim DK (Archives of pharmacal research 2005) 3 22 60
  4. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap AP … Meredith D (Pflugers Archiv : European journal of physiology 2004) 3 22 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SLC16A10 Gene

Sources for SLC16A10 Gene

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