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Aliases for SLC16A10 Gene

Aliases for SLC16A10 Gene

  • Solute Carrier Family 16 (Aromatic Amino Acid Transporter), Member 10 2 3
  • TAT1 3 4 6
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 10 2 3
  • Solute Carrier Family 16 Member 10 3 4
  • Aromatic Amino Acid Transporter 1 3 4
  • T-Type Amino Acid Transporter 1 3 4
  • MCT 10 3 4
  • MCT10 3 4
  • Solute Carrier Family 16, Member 10 (Aromatic Amino Acid Transporter) 3
  • Monocarboxylate Transporter 10 3
  • PRO0813 3

External Ids for SLC16A10 Gene

Previous GeneCards Identifiers for SLC16A10 Gene

  • GC06P111244
  • GC06P111431
  • GC06P111454
  • GC06P111515
  • GC06P108979

Summaries for SLC16A10 Gene

Entrez Gene Summary for SLC16A10 Gene

  • SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC16A10 Gene

SLC16A10 (Solute Carrier Family 16 (Aromatic Amino Acid Transporter), Member 10) is a Protein Coding gene. Diseases associated with SLC16A10 include allan-herndon-dudley syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Protein digestion and absorption. An important paralog of this gene is SLC16A2.

UniProtKB/Swiss-Prot for SLC16A10 Gene

  • Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).

Gene Wiki entry for SLC16A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A10 Gene

Genomics for SLC16A10 Gene

Regulatory Elements for SLC16A10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC16A10 Gene

Start:
111,087,503 bp from pter
End:
111,231,194 bp from pter
Size:
143,692 bases
Orientation:
Plus strand

Genomic View for SLC16A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC16A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A10 Gene

Proteins for SLC16A10 Gene

  • Protein details for SLC16A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF71-MOT10_HUMAN
    Recommended name:
    Monocarboxylate transporter 10
    Protein Accession:
    Q8TF71
    Secondary Accessions:
    • B3KWY0
    • Q6ZMG0
    • Q8WVI5

    Protein attributes for SLC16A10 Gene

    Size:
    515 amino acids
    Molecular mass:
    55493 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17968.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC16A10 Gene

Proteomics data for SLC16A10 Gene at MOPED

Post-translational modifications for SLC16A10 Gene

Other Protein References for SLC16A10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC16A10 Gene

Domains for SLC16A10 Gene

Gene Families for SLC16A10 Gene

Protein Domains for SLC16A10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TF71

UniProtKB/Swiss-Prot:

MOT10_HUMAN :
  • Q8TF71
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A10: view

Function for SLC16A10 Gene

Molecular function for SLC16A10 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with SLC16A10: view
genes like me logo Genes that share phenotypes with SLC16A10: view

Animal Model Products

CRISPR Products

miRNA for SLC16A10 Gene

miRTarBase miRNAs that target SLC16A10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC16A10 Gene

Localization for SLC16A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A10 Gene

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A10 Gene COMPARTMENTS Subcellular localization image for SLC16A10 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
GO:0016323 basolateral plasma membrane TAS 15918515
genes like me logo Genes that share ontologies with SLC16A10: view

Pathways for SLC16A10 Gene

genes like me logo Genes that share pathways with SLC16A10: view

Gene Ontology (GO) - Biological Process for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0015801 aromatic amino acid transport TAS 15918515
GO:0034220 ion transmembrane transport IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC16A10: view

Compounds for SLC16A10 Gene

(1) HMDB Compounds for SLC16A10 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(35) Drugbank Compounds for SLC16A10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Aminoisobutyric Acid
transporter substrate
Beta-Alanine
107-95-9 transporter substrate
D-Alanine
338-69-2 transporter inhibitor
D-Leucine
328-38-1 transporter inhibitor
D-Phenylalanine
673-06-3 transporter substrate inhibitor
genes like me logo Genes that share compounds with SLC16A10: view

Transcripts for SLC16A10 Gene

Unigene Clusters for SLC16A10 Gene

Solute carrier family 16, member 10 (aromatic amino acid transporter):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC16A10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A10 Gene

No ASD Table

Relevant External Links for SLC16A10 Gene

GeneLoc Exon Structure for
SLC16A10
ECgene alternative splicing isoforms for
SLC16A10

Expression for SLC16A10 Gene

mRNA expression in normal human tissues for SLC16A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A10 Gene

This gene is overexpressed in Muscle - Skeletal (17.2) and Pancreas (6.2).

Protein differential expression in normal tissues for SLC16A10 Gene

This gene is overexpressed in Pancreas (28.4), Fetal Liver (13.9), Fetal ovary (9.5), and Placenta (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC16A10 Gene

SOURCE GeneReport for Unigene cluster for SLC16A10 Gene Hs.591327

mRNA Expression by UniProt/SwissProt for SLC16A10 Gene

Q8TF71-MOT10_HUMAN
Tissue specificity: Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.
genes like me logo Genes that share expressions with SLC16A10: view

Expression partners for SLC16A10 Gene

In Situ Assay Products

Orthologs for SLC16A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC16A10 35
  • 89.82 (n)
  • 90.22 (a)
SLC16A10 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A10 35
  • 89.72 (n)
  • 90.05 (a)
SLC16A10 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a10 35
  • 85.03 (n)
  • 84.77 (a)
Slc16a10 16
Slc16a10 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC16A10 35
  • 99.74 (n)
  • 99.42 (a)
SLC16A10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a10 35
  • 84.8 (n)
  • 84.6 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC16A10 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A10 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A10 35
  • 75.69 (n)
  • 77.36 (a)
SLC16A10 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A10 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a10 35
  • 69.39 (n)
  • 72.73 (a)
zebrafish
(Danio rerio)
Actinopterygii slc16a10 35
  • 67.46 (n)
  • 72.27 (a)
slc16a10 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kar 37
  • 45 (a)
kar 35
  • 54.56 (n)
  • 45.77 (a)
kar 36
  • 18 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007743 35
  • 52.74 (n)
  • 46.58 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y19D10A.12 35
  • 43.15 (n)
  • 31.6 (a)
mct-1 36
  • 13 (a)
ManyToMany
mct-2 36
  • 13 (a)
ManyToMany
mct-3 36
  • 11 (a)
ManyToMany
mct-4 36
  • 8 (a)
ManyToMany
mct-5 36
  • 10 (a)
ManyToMany
mct-6 36
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
ManyToMany
-- 36
  • 12 (a)
ManyToMany
CSA.3504 36
  • 15 (a)
ManyToMany
CSA.4076 36
  • 4 (a)
ManyToMany
Species with no ortholog for SLC16A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC16A10 Gene

ENSEMBL:
Gene Tree for SLC16A10 (if available)
TreeFam:
Gene Tree for SLC16A10 (if available)

Paralogs for SLC16A10 Gene

Paralogs for SLC16A10 Gene

Selected SIMAP similar genes for SLC16A10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC16A10: view

Variants for SLC16A10 Gene

Sequence variations from dbSNP and Humsavar for SLC16A10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14399 -- 111,222,741(+) AGTTG(A/C)TTTCC utr-variant-3-prime
rs168522 -- 111,185,425(+) CCAGC(A/G)CTCAG intron-variant
rs187130 -- 111,188,360(+) TTGCA(C/G)AATGC intron-variant
rs191632 -- 111,223,679(-) ATAAG(A/G)ACATG downstream-variant-500B
rs193281 -- 111,166,487(-) ATAAA(C/T)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A10 Gene

Variant ID Type Subtype PubMed ID
nsv886538 CNV Gain 21882294
nsv5440 CNV Insertion 18451855
esv2732574 CNV Deletion 23290073
nsv5441 CNV Insertion 18451855
nsv509149 CNV Insertion 20534489
nsv886539 CNV Gain 21882294
esv2661859 CNV Deletion 23128226
nsv886540 CNV Loss 21882294

Relevant External Links for SLC16A10 Gene

HapMap Linkage Disequilibrium report
SLC16A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A10 Gene

Disorders for SLC16A10 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC16A10 Gene in MalaCards »

(1) Diseases for SLC16A10 Gene including...

(1) University of Copenhagen DISEASES for SLC16A10 Gene

Relevant External Links for SLC16A10

Genetic Association Database (GAD)
SLC16A10
Human Genome Epidemiology (HuGE) Navigator
SLC16A10
genes like me logo Genes that share disorders with SLC16A10: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SLC16A10 Gene

Publications for SLC16A10 Gene

  1. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. (PMID: 11827462) Kim D.K. … Endou H. (Genomics 2002) 2 3 4 23 25
  2. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. (PMID: 11278508) Kim D.K. … Endou H. (J. Biol. Chem. 2001) 2 3 25
  3. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap A.P. … Meredith D. (Pflugers Arch. 2004) 3 23
  4. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. (PMID: 15918515) Park S.Y. … Kim D.K. (Arch. Pharm. Res. 2005) 3 23
  5. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. (PMID: 11278976) Toure A. … Gacon G. (J. Biol. Chem. 2001) 3

Products for SLC16A10 Gene

Sources for SLC16A10 Gene

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