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SLC16A1 Gene

protein-coding GIFtS: 60

GC01M113255

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
(Previous names: solute carrier family 16 (monocarboxylic acid transporters), member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ36745 ^²
HHF7 ^², ⁵
MCT ^¹, ²
MCT1 ^¹, ², ³, ⁵
MGC44475 ^²
OTTHUMP00000013960 ^²

Descriptions
MCT 1 ^³
Solute carrier family 16 member 1 ^³
monocarboxylate transporter 1 ^²
solute carrier family 16 (monocarboxylic acid transporters), member 1 ^¹, ²
solute carrier family 16, member 1 ^²
solute carrier family 16, member 1 (monocarboxylic acid transporter 1) ^²

External Ids
HGNC: 10922¹
Entrez Gene: 6566²
UniProtKB: P53985³
Ensembl: ENSG00000155380⁷

Search outside databases for aliases for SLC16A1 gene

Previous GC identifers: GC01M113870 GC01M112339 GC01M112557 GC01M112753 GC01M113166

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC16A1:

The SLC16A1 gene encodes a monocarboxylate transporter (MCT1) that mediates the movement of lactate

and pyruvate across cell membranes Import and export of these substrates by tissues such as

erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled

MCT (Garcia et al., 1994 [PubMed 8124722]).[supplied by OMIM]

UniProtKB/Swiss-Prot: MOT1_HUMAN, P53985

Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the

plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids

derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate,

beta-hydroxybutyrate and acetate

Gene Wiki entry for SLC16A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SLC16A1 gene

Entrez Gene cytogenetic band: 1p12 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p12

SLC16A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M113255: (about GC identifiers)

Start:	113,255,992 bp from pter
End:	113,300,498 bp from pter
Size:	44,507 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MOT1_HUMAN, P53985 (See protein sequence)

Recommended Name: Monocarboxylate transporter 1

Size: 500 amino acids; 53958 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q9NSJ9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003042.3

ENSEMBL proteins:

ENSP00000358640

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SLC16A1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Monocarboxylic acid transporter 1)
	Human Recombinant Proteins from Abnova (SLC16A1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	8124722
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	TAS	1429658

About this table

Antibodies for SLC16A1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SLC16A1
	Sigma-Aldrich Antibodies for SLC16A1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Monocarboxylic acid transporter 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SLC16A1)
	Novus Biologicals Antibody for SLC16A1

Assays for SLC16A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P53985

ProtoNet protein and cluster: P53985

UniProtKB/Swiss-Prot: MOT1_HUMAN, P53985

Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13)

family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC16A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC16A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003051

Applied Biosystems Silencer® siRNAs for SLC16A1

Sigma-Aldrich siRNA and siRNA Panels for SLC16A1

Sigma-Aldrich shRNA for SLC16A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SLC16A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003051
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003051
untagged cDNA clone in CMV expression vector: NM_003051

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003051

UniProtKB/Swiss-Prot: MOT1_HUMAN, P53985

Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the

plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids

derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate,

beta-hydroxybutyrate and acetate

Genatlas biochemistry entry for SLC16A1:

solute carrier family 16,member A1,monocarboxylic acids transporter,mediating movement of lactate

and pyruvate across membranes

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0015130	mevalonate transmembrane transporter activity	TAS	1429658
GO:0015293	symporter activity	IEA	--
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SLC16A1

5/8 Interacting proteins for SLC16A1 (P53985¹ ENSP00000358640³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AP1S1	P61966¹	EBI-1054708, EBI-516199
DEGS1	O15121¹	EBI-1054708, EBI-1052713
SERINC3	Q13530¹	EBI-1054708, EBI-1045571
BSG	ENSP00000333769³	STRING (score=.988)
MCTS1	ENSP00000360365³	STRING (score=.935)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0015711	organic anion transport	IEA	--
GO:0015728	mevalonate transport	TAS	1429658

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SLC16A1
10/17 Novoseek chemical compound relationships for SLC16A1 gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha-cyano-4-hydroxycinnamate	92.65	11	10918994 (1), 15548847 (1), 19033663 (1), 9447934 (1) (see all 7)
m-coumaric acid	73.74	3	15479001 (2), 15113150 (1)
3-(3-hydroxyphenyl)propionic acid	73.47	4	15479001 (2), 15113150 (1)
pyruvate	69.67	18	16604139 (2), 12739169 (1), 17701893 (1), 18481946 (1) (see all 14)
dids	59.01	2	10918994 (1), 15135232 (1)
bicarbonate	41.39	3	16575022 (1), 12400867 (1), 16269908 (1)
gallic acid	40.22	2	15941309 (1)
beta-hydroxybutyrate	37.85	2	17182800 (1)
glucose	33.56	24	16423989 (2), 19033652 (2), 14724187 (1), 11272148 (1) (see all 14)
sodium	10.34	2	18761711 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC16A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC16A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003051

Sigma-Aldrich siRNA and siRNA Panels for SLC16A1

Sigma-Aldrich shRNA for SLC16A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003051

REFSEQ mRNAs for SLC16A1 gene:

NM_003051.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003051

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003051
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003051
                                 untagged cDNA clone in CMV expression vector: NM_003051

Additional cDNA sequence:

AF239919.1 AJ438942.2 AJ438943.2 AK000641.1 AK094064.1 AK296688.1 AK303603.1 AK312500.1

AL162079.1 BC026317.1 BC045664.1 CR602423.1 CR624057.1 L31801.1

16 DOTS entries:

DT.447811 DT.95200772 DT.95200753 DT.95212264 DT.99979497 DT.100745133 DT.92445931 DT.100818409

DT.121379026 DT.91800069 DT.95316005 DT.102829853 DT.121379090 DT.95220730 DT.91937485 DT.91968405

24/345 AceView cDNA sequences (see all 345 ):

AL559409 X85566 AA436446 AU132155 BM458323 AA367362 BM542763 AI565092

L31801 AU132502 AK094064 BQ379923 AA477683 BF957742 AU123636 CA426348

CB132987 CB270411 AI656300 AW614387 AA649196 AL162079 AI361209 AJ438943

highest scoring ESTs for SLC16A1:

AA206115 AA224459 AA307080 AA355865 AA376008 AI129459 AI984711 AL162079 AU123845 AU129977

Unigene Cluster for SLC16A1:

Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Hs.75231 [show with all ESTs]

Unigene Representative Sequence: NM_003051

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6
SP1:
SP2:
SP3:					-

About this scheme

ECgene alternative splicing isoforms for SLC16A1

1 Ensembl transcript including schematic representation:

ENST00000369626

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SLC16A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SLC16A1

¹ / ² / ³

12 probe-sets matching SLC16A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73253_at²^{, 3}	U95-E	1	1.00	1.00	0.96	1.20	AI984711	0.80	1.00	0.91	1
49197_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.12	AI129459	0.80	1.00	0.91	1
36206_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.71	L31801	0.80	1.00	0.91	1
202235_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF511091	0.60	1.00	0.82	1
202234_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF511091	0.60	1.00	0.82	1
202236_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003051	0.60	1.00	0.82	1
209900_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL162079	0.80	1.00	0.91	1
202235_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557918_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202234_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202236_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209900_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SLC16A1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAATATATTT

SOURCE GeneReport for Unigene cluster: Hs.75231
Expression variation in blood from EXPOLDB for SLC16A1
UniProtKB/Swiss-Prot: MOT1_HUMAN, P53985
Tissue specificity: Widely expressed in normal and in cancer cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC16A1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC16A1¹	--	solute carrier family 16, member 1 (monocarboxylic more	89.74(n) 89.13(a)	475856 XM_533065.2 XP_533065.2
chimpanzee (Pan troglodytes)	SLC16A1¹	--	solute carrier family 16, member 1 (monocarboxylic more	99.67(n) 99.4(a)	457096 XM_001155039.1 XP_001155039.1
cow (Bos taurus)	SLC16A1¹	--	solute carrier family 16, member 1 (monocarboxylic more	87.53(n) 85(a)	505775 NM_001037319.1 NP_001032396.1
rat (Rattus norvegicus)	Slc16a1¹	--	solute carrier family 16, member 1 (monocarboxylic more	84.45(n) 86(a)	25027 NM_012716.1 NP_036848.1
mouse (Mus musculus)	Slc16a1^{1, 5}	3⁵	solute carrier family 16 (monocarboxylic acid transporters), more^{1, 5}	84.49(n)¹ 87.6(a)¹	20501¹ NM_009196.3¹ NP_033222.1¹ AF058055⁵ AK033516⁵ (see all 16)

About this table Species with no ortholog for SLC16A1

ENSEMBL Gene Tree for SLC16A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SLC16A1 gene

SLC16A7²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/240 NCBI SNPs in SLC16A1 are shown (see all 240 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7169^1,2	A,C,F,H,O	113256622(-)	`AGATAC/TAGACA`	1	--	ut3¹ ese³		15		MN EA NA EU WA	2864
	rs1049434^1,2	A,C,F,H	113258069(-)	`ACAGAA/TGGAGG`	1	D/E	mis¹ ese³		22		EA MN NA EU WA	3494
	rs9429505^1,2	C,F,H	113256094(+)	`GAAGAA/GGTACG`	1	--	ut3¹ ese³ trp³		7		NA EU EA WA	562
	rs17493313^1,2	C,F,H	113255947(+)	`GAAAGT/CGCTAT`	1	--	ng5¹		7		NA EU EA WA	562
	rs11811205^1,2	C,F,H	113256160(+)	`CCTGCC/GAATAC`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs11585690^1,2	F,H	113257891(+)	`AACAAA/CAATCC`	1	--	ut3¹ ese³		4		EU EA WA	418
--	rs6699036^1,2	A,C	113300973(+)	`CAGTAA/GTAGAA`	1	--	ng3¹		0	--	--	--	--
	rs9429504^1,2	F,H	113255505(+)	`tatccG/Agtagt`	1	--	ng5¹		4		EU EA WA	420
--	rs11551867^1,2	H	113266243(-)	`ATGGAA/GGTCGT`	1	S/G	mis¹		4		EU EA WA	406
	rs7416738^1,2	H	113255838(+)	`TGCTTC/TTGAAT`	1	--	ng5¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for SLC16A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600682 disorders: 245340 610021

UniProtKB/Swiss-Prot: MOT1_HUMAN, P53985

Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT)

[MIM:245340]; also known as erythrocyte lactate transporter defect. Deficiency of lactate

transporter may result in an acidic intracellular environment created by muscle activity with

consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might

compromise extreme performance in otherwise healthy individuals

Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7)

[MIM:610021]; also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly

inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic

exercise or on pyruvate load

10 Novoseek disease relationships for SLC16A1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acidosis	24.88	2	12400867 (1), 16269908 (1)
colon cancer	20.90	4	16042588 (2), 16405400 (1)
hypoglycemia	14.39	2	17701893 (2)
necrosis	0.00	3	15574223 (1), 10774612 (1)
melanoma	0.00	1	18778892 (1)
cancer	0.00	12	19033652 (3), 9786900 (1), 16423989 (1)
glioma	0.00	1	11277580 (1)
carcinoma	0.00	2	11953883 (2)
tumors	0.00	12	12479094 (2), 16136905 (2), 18778892 (1), 19033652 (1) (see all 6)
adenocarcinoma	0.00	6	16423989 (1), 17760565 (1), 14525727 (1)

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Human Gene Mutation Database: SLC16A1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/155 PubMed articles for SLC16A1 gene (see all 155 ):

cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. (PubMed id 7835905)^{1, 2, 3, 4} Garcia C.K....Francke U. (1994)
Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. (PubMed id 17701893)^{1, 3, 4} Otonkoski T....Kere J. (2007)
Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. (PubMed id 8124722)^{1, 2, 3} Garcia C.K....Brown M.S. (1994)
Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport. (PubMed id 10590411)^{1, 3, 4} Merezhinskaya N.... Foellmer J.W. (2000)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. (PubMed id 11882670)^{1, 3} Cuff M.A....Shirazi-Beechey S.P. (2002)
PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. (PubMed id 19033536)^{1, 3} Saksena S....Dudeja P.K. (2009)
The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. (PubMed id 11944921)^{1, 3} Cuff M.A. and Shirazi-Beechey S.P. (2002)
The expression of lactate transporters (MCT1 and MCT4) in heart and muscle. (PubMed id 11820324)^{1, 3} Bonen A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6566	HGNC: 10922	AceView: SLC16A1	Ensembl:ENSG00000155380	euGenes: HUgn6566
ECgene: SLC16A1	H-InvDB: SLC16A1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SLC16A1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SLC16A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SLC16A1-related products

	Millipore Custom Antibody & Bulk Services
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	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SLC16A1		Antibodies for SLC16A1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SLC16A1		Browse small molecules at Sigma-Aldrich
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SLC16A1)
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	Chimera RNAi (SLC16A1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Monocarboxylic acid transporter 1)
	Antibodies (Monocarboxylic acid transporter 1)

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Antibodies for SLC16A1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SLC16A1 Gene at Home site.
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SLC16A1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for SLC16A1

Summaries
for SLC16A1

Genomic Location
for SLC16A1

Proteins
for SLC16A1

Protein Domains/
Families
for SLC16A1

Gene Function
for SLC16A1

Pathways & Interactions
for SLC16A1

Drugs & Compounds
for SLC16A1

Transcripts
for SLC16A1

Expression
for SLC16A1

Orthologs
for SLC16A1

Paralogs
for SLC16A1

SNPs/Variants
for SLC16A1

Disorders & Mutations
for SLC16A1

Medical News
for SLC16A1

Publications
for SLC16A1

Search for SLC16A1

Genome Databases showing SLC16A1

Other Databases showing SLC16A1

Specialized Databases showing SLC16A1

Licensable Technologies
for SLC16A1

Services
for SLC16A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SLC16A1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor SLC16A1

Summariesfor SLC16A1

Genomic Locationfor SLC16A1

Proteinsfor SLC16A1

Protein Domains/Familiesfor SLC16A1

Gene Functionfor SLC16A1

Pathways & Interactionsfor SLC16A1

Drugs & Compoundsfor SLC16A1

Transcriptsfor SLC16A1

Expression for SLC16A1

Orthologsfor SLC16A1

Paralogsfor SLC16A1

SNPs/Variantsfor SLC16A1

Disorders & Mutationsfor SLC16A1

Medical Newsfor SLC16A1

Publicationsfor SLC16A1

Search for SLC16A1

Genome Databases showing SLC16A1

Other Databases showing SLC16A1

Specialized Databases showing SLC16A1

Licensable Technologiesfor SLC16A1

Servicesfor SLC16A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SLC16A1

Summaries
for SLC16A1

Genomic Location
for SLC16A1

Proteins
for SLC16A1

Protein Domains/
Families
for SLC16A1

Gene Function
for SLC16A1

Pathways & Interactions
for SLC16A1

Drugs & Compounds
for SLC16A1

Transcripts
for SLC16A1

Expression
for SLC16A1

Orthologs
for SLC16A1

Paralogs
for SLC16A1

SNPs/Variants
for SLC16A1

Disorders & Mutations
for SLC16A1

Medical News
for SLC16A1

Publications
for SLC16A1

Licensable Technologies
for SLC16A1

Services
for SLC16A1