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Aliases for SLC16A1 Gene

Aliases for SLC16A1 Gene

  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 1 2 3
  • MCT1 3 4 6
  • Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 1 2 3
  • MCT 1 3 4
  • HHF7 3 6
  • Solute Carrier Family 16 Member 1 4
  • Monocarboxylate Transporter 1 3
  • MCT1D 3
  • MCT 3

External Ids for SLC16A1 Gene

Previous GeneCards Identifiers for SLC16A1 Gene

  • GC01M113870
  • GC01M112339
  • GC01M112557
  • GC01M112753
  • GC01M113166
  • GC01M113255
  • GC01M113454
  • GC01M111313

Summaries for SLC16A1 Gene

Entrez Gene Summary for SLC16A1 Gene

  • The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

GeneCards Summary for SLC16A1 Gene

SLC16A1 (Solute Carrier Family 16 (Monocarboxylate Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC16A1 include erythrocyte lactate transporter defect and hyperinsulinemic hypoglycemia, familial, 7. Among its related pathways are Hemostasis and Metabolism. GO annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A1 Gene

  • Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

Tocris Summary for SLC16A1 Gene

  • Monocarboxylate transporters (MCT)catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such asL-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

Gene Wiki entry for SLC16A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A1 Gene

Genomics for SLC16A1 Gene

Regulatory Elements for SLC16A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC16A1 Gene

Start:
112,911,847 bp from pter
End:
112,957,013 bp from pter
Size:
45,167 bases
Orientation:
Minus strand

Genomic View for SLC16A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC16A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A1 Gene

Proteins for SLC16A1 Gene

  • Protein details for SLC16A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53985-MOT1_HUMAN
    Recommended name:
    Monocarboxylate transporter 1
    Protein Accession:
    P53985
    Secondary Accessions:
    • Q49A45
    • Q5T8R6
    • Q9NSJ9

    Protein attributes for SLC16A1 Gene

    Size:
    500 amino acids
    Molecular mass:
    53944 Da
    Quaternary structure:
    • Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.
    Miscellaneous:
    • Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise

    Alternative splice isoforms for SLC16A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A1 Gene

Proteomics data for SLC16A1 Gene at MOPED

Post-translational modifications for SLC16A1 Gene

  • Ubiquitination at Lys224 and Lys479
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC16A1 Gene

Antibody Products

  • R&D Systems Antibodies for SLC16A1 (MCT1/SLC16A1)

No data available for DME Specific Peptides for SLC16A1 Gene

Domains for SLC16A1 Gene

Gene Families for SLC16A1 Gene

Protein Domains for SLC16A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53985

UniProtKB/Swiss-Prot:

MOT1_HUMAN :
  • P53985
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A1: view

Function for SLC16A1 Gene

Molecular function for SLC16A1 Gene

GENATLAS Biochemistry:
solute carrier family 16,member A1,monocarboxylic acids transporter,mediating movement of lactate and pyruvate across membranes
UniProtKB/Swiss-Prot Function:
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

Gene Ontology (GO) - Molecular Function for SLC16A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS 8124722
GO:0015129 lactate transmembrane transporter activity IBA --
GO:0015130 mevalonate transmembrane transporter activity TAS 1429658
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A1: view

Phenotypes for SLC16A1 Gene

GenomeRNAi human phenotypes for SLC16A1:
genes like me logo Genes that share phenotypes with SLC16A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC16A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC16A1 Gene

Localization for SLC16A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A1 Gene COMPARTMENTS Subcellular localization image for SLC16A1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC16A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA 23816619
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with SLC16A1: view

Pathways for SLC16A1 Gene

genes like me logo Genes that share pathways with SLC16A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC16A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0006629 lipid metabolic process IEA --
GO:0007596 blood coagulation TAS --
GO:0015711 organic anion transport --
GO:0015718 monocarboxylic acid transport TAS 8124722
genes like me logo Genes that share ontologies with SLC16A1: view

Compounds for SLC16A1 Gene

(2) Tocris Compounds for SLC16A1 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor [496791-37-8]
UK 5099 Inhibitor of pyruvate transport [56396-35-1]

(2) HMDB Compounds for SLC16A1 Gene

Compound Synonyms Cas Number PubMed IDs
Butyric acid
  • 1-Butyrate
107-92-6
Pyruvic acid
  • 2-Oxopropanoate
127-17-3

(24) Drugbank Compounds for SLC16A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
6-Deoxyglucose
transporter inhibitor
Acetic acid
  • Ethanoat
64-19-7 transporter substrate
Acetoacetic Acid
541-50-4 transporter substrate inhibitor
Alpha-ketoisovalerate
  • 2-Keto-3-methylbutyric acid
759-05-7 transporter inhibitor
Aminohippurate
  • Aminohippurate Sodium
94-16-6 transporter substrate

(34) Novoseek inferred chemical compound relationships for SLC16A1 Gene

Compound -log(P) Hits PubMed IDs
alpha-cyano-4-hydroxycinnamate 92.6 8
lactate 81.7 148
butyrate 74.9 57
pyruvate 72.4 18
m-coumaric acid 72.3 3
genes like me logo Genes that share compounds with SLC16A1: view

Transcripts for SLC16A1 Gene

Unigene Clusters for SLC16A1 Gene

Solute carrier family 16, member 1 (monocarboxylic acid transporter 1):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC16A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2:
SP3: -

Relevant External Links for SLC16A1 Gene

GeneLoc Exon Structure for
SLC16A1
ECgene alternative splicing isoforms for
SLC16A1

Expression for SLC16A1 Gene

mRNA expression in normal human tissues for SLC16A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SLC16A1 Gene

This gene is overexpressed in Retina (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC16A1 Gene

SOURCE GeneReport for Unigene cluster for SLC16A1 Gene Hs.75231

mRNA Expression by UniProt/SwissProt for SLC16A1 Gene

P53985-MOT1_HUMAN
Tissue specificity: Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.
genes like me logo Genes that share expressions with SLC16A1: view

Expression partners for SLC16A1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC16A1 Gene

Orthologs for SLC16A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC16A1 35
  • 87.47 (n)
  • 85 (a)
SLC16A1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A1 35
  • 89.67 (n)
  • 89.13 (a)
MCT1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a1 35
  • 84.01 (n)
  • 87.2 (a)
Slc16a1 16
Slc16a1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC16A1 35
  • 99.67 (n)
  • 99.4 (a)
SLC16A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a1 35
  • 84.45 (n)
  • 86 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC16A1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A1 35
  • 73.57 (n)
  • 80.48 (a)
SLC16A1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a1 35
  • 70.14 (n)
  • 75.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia slc16a1-prov 35
zebrafish
(Danio rerio)
Actinopterygii slc16a1 35
  • 68.63 (n)
  • 77.29 (a)
slc16a1 36
  • 78 (a)
OneToMany
SLC16A1 (1 of 2) 36
  • 74 (a)
OneToMany
Species with no ortholog for SLC16A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A1 Gene

ENSEMBL:
Gene Tree for SLC16A1 (if available)
TreeFam:
Gene Tree for SLC16A1 (if available)

Paralogs for SLC16A1 Gene

Selected SIMAP similar genes for SLC16A1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SLC16A1 Gene

genes like me logo Genes that share paralogs with SLC16A1: view

Variants for SLC16A1 Gene

Sequence variations from dbSNP and Humsavar for SLC16A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7169 -- 112,912,477(-) AGATA(C/T)AGACA utr-variant-3-prime
rs1049434 Benign, - 112,913,924(-) ACAGA(A/T)GGAGG missense, reference
rs1216536 -- 112,916,220(+) ATGga(C/T)caggc intron-variant
rs1344429 -- 112,918,061(+) ataaa(G/T)aaata intron-variant
rs2149035 -- 112,937,179(+) AGTAG(G/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A1 Gene

Variant ID Type Subtype PubMed ID
essv21692 CNV CNV 17122850
esv24626 CNV Loss 19812545
nsv483141 CNV Gain 15286789

Relevant External Links for SLC16A1 Gene

HapMap Linkage Disequilibrium report
SLC16A1
Human Gene Mutation Database (HGMD)
SLC16A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A1 Gene

Disorders for SLC16A1 Gene

(2) OMIM Diseases for SLC16A1 Gene (600682)

UniProtKB/Swiss-Prot

MOT1_HUMAN
  • Symptomatic deficiency in lactate transport (SDLT) [MIM:245340]: Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. {ECO:0000269 PubMed:10590411}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Familial hyperinsulinemic hypoglycemia 7 (HHF7) [MIM:610021]: Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. {ECO:0000269 PubMed:17701893}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Monocarboxylate transporter 1 deficiency (MCT1D) [MIM:616095]: A metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death. {ECO:0000269 PubMed:25390740}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(11) Novoseek inferred disease relationships for SLC16A1 Gene

Disease -log(P) Hits PubMed IDs
acidosis 29.1 2
colon cancer 17.4 3
adenocarcinoma 16.2 5
hypoglycemia 11 2
ischemia 0 2

Relevant External Links for SLC16A1

Genetic Association Database (GAD)
SLC16A1
Human Genome Epidemiology (HuGE) Navigator
SLC16A1
genes like me logo Genes that share disorders with SLC16A1: view

No data available for University of Copenhagen DISEASES and Genatlas for SLC16A1 Gene

Publications for SLC16A1 Gene

  1. cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. (PMID: 7835905) Garcia C.K. … Francke U. (Genomics 1994) 2 3 4 23
  2. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. (PMID: 8124722) Garcia C.K. … Brown M.S. (Cell 1994) 2 3 23
  3. Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport. (PMID: 10590411) Merezhinskaya N. … Foellmer J.W. (Muscle Nerve 2000) 3 4 23
  4. The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. (PMID: 11944921) Cuff M.A. … Shirazi-Beechey S.P. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  5. Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. (PMID: 15505343) Merezhinskaya N. … Fishbein W.N. (J. Histochem. Cytochem. 2004) 3 4 23

Products for SLC16A1 Gene

Sources for SLC16A1 Gene

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