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Aliases for SLC15A5 Gene

Aliases for SLC15A5 Gene

  • Solute Carrier Family 15 Member 5 2 3 5
  • Solute Carrier Family 15, Member 5 2

External Ids for SLC15A5 Gene

Previous GeneCards Identifiers for SLC15A5 Gene

  • GC12M016235
  • GC12M016343
  • GC12M016110

Summaries for SLC15A5 Gene

GeneCards Summary for SLC15A5 Gene

SLC15A5 (Solute Carrier Family 15 Member 5) is a Protein Coding gene. GO annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot for SLC15A5 Gene

  • Proton oligopeptide cotransporter.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A5 Gene

Genomics for SLC15A5 Gene

Regulatory Elements for SLC15A5 Gene

Enhancers for SLC15A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G016346 1.3 ENCODE dbSUPER 15.6 -72.4 -72426 6.9 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS SP3 SP5 MGST1 SLC15A5 GC12P016380
GH12G016353 0.7 Ensembl dbSUPER 10.6 -76.5 -76516 0.8 NFIB HNF4A SLC15A5 MGST1 GC12P016380
GH12G016280 0.6 ENCODE 0.7 -3.7 -3693 1.3 MAX RAD21 GABPA YY1 FOXA1 JUND ATF3 HNF4G HNF4A MGST1 SLC15A5 PIR41579
GH12G016176 0.3 FANTOM5 1.4 +101.5 101514 0.3 MGST1 SLC15A5 GC12M016137 GC12P016202
GH12G016299 0.5 ENCODE 0.3 -22.6 -22614 1.5 ZNF316 SCRT2 ATF2 MAFK MGST1 PIR41579 SLC15A5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC15A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC15A5 Gene

Chromosome:
12
Start:
16,188,485 bp from pter
End:
16,277,685 bp from pter
Size:
89,201 bases
Orientation:
Minus strand

Genomic View for SLC15A5 Gene

Genes around SLC15A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A5 Gene

Proteins for SLC15A5 Gene

  • Protein details for SLC15A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIM6-S15A5_HUMAN
    Recommended name:
    Solute carrier family 15 member 5
    Protein Accession:
    A6NIM6

    Protein attributes for SLC15A5 Gene

    Size:
    579 amino acids
    Molecular mass:
    65263 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A5 Gene

Post-translational modifications for SLC15A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC15A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC15A5 Gene

Domains & Families for SLC15A5 Gene

Gene Families for SLC15A5 Gene

Protein Domains for SLC15A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC15A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIM6

UniProtKB/Swiss-Prot:

S15A5_HUMAN :
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A5: view

Function for SLC15A5 Gene

Molecular function for SLC15A5 Gene

UniProtKB/Swiss-Prot Function:
Proton oligopeptide cotransporter.

Gene Ontology (GO) - Molecular Function for SLC15A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC15A5: view

Phenotypes for SLC15A5 Gene

GenomeRNAi human phenotypes for SLC15A5:
genes like me logo Genes that share phenotypes with SLC15A5: view

Animal Model Products

miRNA for SLC15A5 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC15A5 Gene

Localization for SLC15A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC15A5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC15A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC15A5: view

Pathways & Interactions for SLC15A5 Gene

SuperPathways for SLC15A5 Gene

No Data Available

Interacting Proteins for SLC15A5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340402%0d%0a9606.ENSP00000290650%0d%0a9606.ENSP00000361990%0d%0a9606.ENSP00000217233%0d%0a
Selected Interacting proteins: ENSP00000340402 for SLC15A5 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC15A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC15A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC15A5 Gene

Drugs & Compounds for SLC15A5 Gene

No Compound Related Data Available

Transcripts for SLC15A5 Gene

mRNA/cDNA for SLC15A5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC15A5 Gene

Solute carrier family 15, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A5 Gene

No ASD Table

Relevant External Links for SLC15A5 Gene

GeneLoc Exon Structure for
SLC15A5
ECgene alternative splicing isoforms for
SLC15A5

Expression for SLC15A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC15A5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC15A5 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.5), Brain - Amygdala (x5.4), and Brain - Anterior cingulate cortex (BA24) (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of SLC15A5 Gene:

SLC15A5

SOURCE GeneReport for Unigene cluster for SLC15A5 Gene:

Hs.692712

Evidence on tissue expression from TISSUES for SLC15A5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC15A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A5 Gene

Orthologs for SLC15A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC15A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A5 34 35
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia SLC15A5 34 35
  • 87.89 (n)
cow
(Bos Taurus)
Mammalia SLC15A5 34 35
  • 83.79 (n)
mouse
(Mus musculus)
Mammalia Slc15a5 34 16 35
  • 75.77 (n)
rat
(Rattus norvegicus)
Mammalia Slc15a5 34
  • 75.44 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC15A5 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC15A5 34 35
  • 65.66 (n)
lizard
(Anolis carolinensis)
Reptilia SLC15A5 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733983 34
  • 62.14 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799543 34
  • 59.54 (n)
SLC15A5 35
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9444 35
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 4 (a)
OneToMany
Species where no ortholog for SLC15A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC15A5 Gene

ENSEMBL:
Gene Tree for SLC15A5 (if available)
TreeFam:
Gene Tree for SLC15A5 (if available)

Paralogs for SLC15A5 Gene

Paralogs for SLC15A5 Gene

genes like me logo Genes that share paralogs with SLC15A5: view

Variants for SLC15A5 Gene

Sequence variations from dbSNP and Humsavar for SLC15A5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000005312 -- 16,199,491(+) TTTAT(C/T)TTTCT intron-variant
rs1000006850 -- 16,259,346(+) CACTC(C/G)CTCCC intron-variant
rs1000008817 -- 16,218,353(+) ATAAG(A/T)AAATA intron-variant
rs1000047058 -- 16,237,224(+) AACTT(A/G)TTAAT intron-variant
rs1000101822 -- 16,252,972(+) GAGCC(C/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A5 Gene

Variant ID Type Subtype PubMed ID
dgv2392n54 CNV loss 21841781
dgv2393n54 CNV gain+loss 21841781
dgv274n67 CNV loss 20364138
dgv43n73 CNV deletion 24416366
dgv776n106 CNV deletion 24896259
esv1001083 CNV loss 20482838
esv1003486 CNV loss 20482838
esv2661182 CNV deletion 23128226
esv26884 CNV gain+loss 19812545
esv2745595 CNV deletion 23290073
esv2759881 CNV gain 17122850
esv3253718 CNV deletion 24192839
esv3548814 CNV deletion 23714750
esv3580162 CNV loss 25503493
esv3628686 CNV loss 21293372
esv3628687 CNV loss 21293372
esv3628688 CNV loss 21293372
esv3892149 CNV loss 25118596
esv999691 CNV deletion 20482838
nsv1036638 CNV loss 25217958
nsv1038946 CNV loss 25217958
nsv1039831 CNV loss 25217958
nsv1068261 CNV deletion 25765185
nsv1119936 CNV deletion 24896259
nsv1151534 CNV deletion 26484159
nsv428273 CNV loss 18775914
nsv512257 CNV loss 21212237
nsv52662 CNV deletion 16902084
nsv557639 CNV loss 21841781
nsv557641 CNV gain 21841781
nsv557644 CNV gain 21841781
nsv557645 CNV loss 21841781
nsv821614 CNV deletion 20802225
nsv826267 CNV loss 20364138
nsv832336 CNV gain 17160897

Variation tolerance for SLC15A5 Gene

Gene Damage Index Score: 5.07; 68.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC15A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC15A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A5 Gene

Disorders for SLC15A5 Gene

Relevant External Links for SLC15A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC15A5

No disorders were found for SLC15A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC15A5 Gene

Publications for SLC15A5 Gene

  1. Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. (PMID: 21044875) Sreedharan S. … Fredriksson R. (Gene 2011) 2 3 64
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64

Products for SLC15A5 Gene

Sources for SLC15A5 Gene

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