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Aliases for SLC15A5 Gene

Aliases for SLC15A5 Gene

  • Solute Carrier Family 15 Member 5 2 3
  • Solute Carrier Family 15, Member 5 2 5

External Ids for SLC15A5 Gene

Previous GeneCards Identifiers for SLC15A5 Gene

  • GC12M016235
  • GC12M016343
  • GC12M016110

Summaries for SLC15A5 Gene

GeneCards Summary for SLC15A5 Gene

SLC15A5 (Solute Carrier Family 15 Member 5) is a Protein Coding gene. GO annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot for SLC15A5 Gene

  • Proton oligopeptide cotransporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A5 Gene

Genomics for SLC15A5 Gene

Regulatory Elements for SLC15A5 Gene

Enhancers for SLC15A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC15A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC15A5 Gene

16,188,485 bp from pter
16,277,685 bp from pter
89,201 bases
Minus strand

Genomic View for SLC15A5 Gene

Genes around SLC15A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A5 Gene

Proteins for SLC15A5 Gene

  • Protein details for SLC15A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 15 member 5
    Protein Accession:

    Protein attributes for SLC15A5 Gene

    579 amino acids
    Molecular mass:
    65263 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A5 Gene

Proteomics data for SLC15A5 Gene at MOPED

Post-translational modifications for SLC15A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC15A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC15A5 Gene

Domains & Families for SLC15A5 Gene

Gene Families for SLC15A5 Gene

Protein Domains for SLC15A5 Gene


Suggested Antigen Peptide Sequences for SLC15A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A5: view

Function for SLC15A5 Gene

Molecular function for SLC15A5 Gene

UniProtKB/Swiss-Prot Function:
Proton oligopeptide cotransporter.

Phenotypes for SLC15A5 Gene

GenomeRNAi human phenotypes for SLC15A5:
genes like me logo Genes that share phenotypes with SLC15A5: view

Animal Model Products

miRNA for SLC15A5 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC15A5 Gene

Localization for SLC15A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC15A5 Gene COMPARTMENTS Subcellular localization image for SLC15A5 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for SLC15A5 Gene

Pathways & Interactions for SLC15A5 Gene

SuperPathways for SLC15A5 Gene

No Data Available

Interacting Proteins for SLC15A5 Gene

Gene Ontology (GO) - Biological Process for SLC15A5 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC15A5 Gene

Drugs & Compounds for SLC15A5 Gene

No Compound Related Data Available

Transcripts for SLC15A5 Gene

mRNA/cDNA for SLC15A5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC15A5 Gene

Solute carrier family 15, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A5 Gene

No ASD Table

Relevant External Links for SLC15A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC15A5 Gene

mRNA expression in normal human tissues for SLC15A5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC15A5 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.5), Brain - Amygdala (x5.4), and Brain - Anterior cingulate cortex (BA24) (x5.1).

SOURCE GeneReport for Unigene cluster for SLC15A5 Gene Hs.692712

genes like me logo Genes that share expression patterns with SLC15A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC15A5 Gene

Orthologs for SLC15A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC15A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC15A5 35
  • 83.79 (n)
  • 78.2 (a)
SLC15A5 36
  • 77 (a)
(Canis familiaris)
Mammalia SLC15A5 35
  • 87.89 (n)
  • 82.01 (a)
SLC15A5 36
  • 82 (a)
(Mus musculus)
Mammalia Slc15a5 35
  • 75.77 (n)
  • 64.89 (a)
Slc15a5 16
Slc15a5 36
  • 64 (a)
(Pan troglodytes)
Mammalia SLC15A5 35
  • 98.96 (n)
  • 97.93 (a)
SLC15A5 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Slc15a5 35
  • 75.44 (n)
  • 64.49 (a)
(Monodelphis domestica)
Mammalia SLC15A5 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
(Gallus gallus)
Aves SLC15A5 35
  • 65.66 (n)
  • 57.17 (a)
SLC15A5 36
  • 56 (a)
(Anolis carolinensis)
Reptilia SLC15A5 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733983 35
  • 62.14 (n)
  • 57.41 (a)
(Danio rerio)
Actinopterygii LOC799543 35
  • 59.54 (n)
  • 54.06 (a)
SLC15A5 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9444 36
  • 15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
Species with no ortholog for SLC15A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC15A5 Gene

Gene Tree for SLC15A5 (if available)
Gene Tree for SLC15A5 (if available)

Paralogs for SLC15A5 Gene

Paralogs for SLC15A5 Gene

genes like me logo Genes that share paralogs with SLC15A5: view

Variants for SLC15A5 Gene

Sequence variations from dbSNP and Humsavar for SLC15A5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_042979 -
rs1527014 - 16,244,743(+) ATTGC(A/G)GGTGG reference, missense
VAR_042981 -
VAR_042982 -
rs7134052 -- 16,242,568(+) AAGCC(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A5 Gene

Variant ID Type Subtype PubMed ID
nsv832336 CNV Gain 17160897
dgv480e1 CNV Complex 17122850
nsv428273 CNV Loss 18775914
nsv898826 CNV Loss 21882294
nsv52662 CNV Loss 16902084
nsv512257 CNV Loss 21212237
dgv274n67 CNV Loss 20364138
nsv821614 CNV Deletion 20802225
esv2745595 CNV Deletion 23290073
esv999691 CNV Deletion 20482838
esv2661182 CNV Deletion 23128226
esv1003486 CNV Loss 20482838
esv26884 CNV Gain+Loss 19812545
nsv826267 CNV Loss 20364138
esv1001083 CNV Loss 20482838

Variation tolerance for SLC15A5 Gene

Gene Damage Index Score: 5.07; 68.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC15A5 Gene

Disorders for SLC15A5 Gene

Relevant External Links for SLC15A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC15A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC15A5 Gene

Publications for SLC15A5 Gene

  1. Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. (PMID: 21044875) Sreedharan S. … Fredriksson R. (Gene 2011) 2 3 67
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3

Products for SLC15A5 Gene

Sources for SLC15A5 Gene