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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC15A4 Gene

protein-coding   GIFtS: 53
GCID: GC12M129277

solute carrier family 15, member 4
 Explore 4 diseases affiliated with
SLC15A4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC15A4    

Aliases
for SLC15A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 15, Member 41 2     Peptide/Histidine Transporter 12 3
PHT11 2 3     HPHT11
PTR41 2 3     Peptide-Histidine Transporter 42
Peptide Transporter 42 3     Solute Carrier Family 15 Member 42

External Ids:    HGNC: 230901   Entrez Gene: 1212602   Ensembl: ENSG000001393707   UniProtKB: Q8N6973   

Export aliases for SLC15A4 gene to outside databases

Previous GC identifers: GC12M129016 GC12M127630 GC12M127802 GC12M126263


Summaries
for SLC15A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: S15A4_HUMAN, Q8N697
Function: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides




Genomic Views
for SLC15A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC15A4 gene promoter:
         p53   Pax-5   NCX/Ncx   E2F-2   AP-4   MEF-2A   E2F   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC15A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC15A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC15A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.32   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.32

SLC15A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC15A4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M129277:  view genomic region     (about GC identifiers)

Start:
 129,277,739 bp from pter      End:
 129,308,541 bp from pter
Size:
 30,803 bases      Orientation:
 minus strand

Proteins
for SLC15A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S15A4_HUMAN, Q8N697 (See protein sequence)
Recommended Name: Solute carrier family 15 member 4  
Size: 577 amino acids; 62034 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAI46804.1; Type=Frameshift; Positions=342; Sequence=AAK95565.1; Type=Frameshift;
Positions=572; Sequence=AAQ04807.1; Type=Frameshift; Positions=497;
Secondary accessions: A6H8Y9 B3KTK1 Q71M34 Q7Z5F8 Q8TAH0
Alternative splicing: 2 isoforms:  Q8N697-1   Q8N697-2   

Explore the universe of human proteins at neXtProt for SLC15A4: NX_Q8N697

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N697

    • SLC15A4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_663623.1  
    ENSEMBL proteins: 
     ENSP00000266771   ENSP00000365935   ENSP00000444276   ENSP00000439946   ENSP00000365930  
    Reactome Protein details: Q8N697
    Human Recombinant Protein Products: 
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    Browse OriGene Protein Over-expression Lysates
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC15A4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    SLC15A4 for ontologies           About GeneDecksing



    SLC15A4 Antibody Products: 
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    Novus Biologicals SLC15A4 Antibodies
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    Uscn Antibodies for SLC15A4
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    Assay Products for SLC15A4: 
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    Uscn ELISAs and CLIAs for SLC15A4

    Protein Domains /
    Families
    for SLC15A4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC15A4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018456 PTR2_symporter_CS
     IPR000109 POT_fam
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8N697

    ProtoNet protein and cluster: Q8N697

    1 Blocks protein family: IPB000109 TGF-beta receptor

    UniProtKB/Swiss-Prot: S15A4_HUMAN, Q8N697
    Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family


    Function
    for SLC15A4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S15A4_HUMAN, Q8N697
    Function: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides

    miRNA
    Products:            		miRTarBase miRNAs that target SLC15A4:
    hsa-mir-124 (MIRT002585)

    OriGene 3'-UTR Clone: SLC15A4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC15A4
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC15A4:
    hsa-miR-31 hsa-miR-3910 hsa-miR-124 hsa-miR-374b hsa-miR-506 hsa-miR-374a hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmid: SLC15A4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC15A4 (see all 7)
    OriGene shRNA RFP: SLC15A4
    OriGene siRNA: SLC15A4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC15A4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC15A4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A4 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: SLC15A4 (NM_145648)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC15A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC15A4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC15A4
    Search LifeMap BioReagents cell lines for SLC15A4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005290L-histidine transmembrane transporter activity IEA--
    GO:0015293symporter activity IEA--


    SLC15A4 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Slc15a4):
     immune system 

    SLC15A4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC15A4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino acid and oligopeptide SLC transporters
    		Amino acid and oligopeptide SLC transporters1.00
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Proton/oligonucleotide cotransporters
    		Proton/oligonucleotide cotransporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC15A4
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides
    Proton/oligonucleotide cotransporters



    SLC15A4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC15A4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC15A4 (ENSP000002667714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006857oligopeptide transport IEA--
    GO:0015031protein transport IEA--
    GO:0015817histidine transport ----
    GO:0055085transmembrane transport TAS--


    SLC15A4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC15A4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC15A4
    Search CenterWatch for drugs/clinical trials and news about SLC15A4 / S15A4 

    Transcripts
    for SLC15A4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC15A4 gene: 
    NM_145648.3  

    Unigene Cluster for SLC15A4:

    Solute carrier family 15, member 4
    Hs.507260  [show with all ESTs]
    Unigene Representative Sequence: CR936821
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266771(uc001uhu.2 uc001uhv.2) ENST00000376744 ENST00000545031
    ENST00000544112 ENST00000366292 ENST00000376740 ENST00000539703 ENST00000535272


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SLC15A4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC15A4
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC15A4:
    hsa-miR-31 hsa-miR-3910 hsa-miR-124 hsa-miR-374b hsa-miR-506 hsa-miR-374a hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmid: SLC15A4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC15A4 (see all 7)
    OriGene shRNA RFP: SLC15A4
    OriGene siRNA: SLC15A4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC15A4
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC15A4 (NM_145648)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC15A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC15A4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC15A4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC15A4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC15A4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC15A4

    Additional cDNA sequence: 

    AF461893.1 AK095717.1 AK097154.1 AY038999.1 AY050629.1 BC028394.2 BC146803.1 CR936821.1 

    9 DOTS entries:

    DT.100793202  DT.95276912  DT.100793204  DT.100025210  DT.92432162  DT.95276919  DT.211675  DT.121158152 
    DT.40198494 

    24/252 AceView cDNA sequences (see all 252):

    AA287817 AI685360 AW629286 AA478573 AA761785 AW304786 AI829672 BF514333 
    AA768830 AA913468 AI660053 AI273268 AI885507 BX419419 AW573006 BG150148 
    BE044253 CD676230 AI420752 BQ015164 AU185890 AA830471 BI962732 AW517973 

    GeneLoc Exon Structure


    Expression
    for SLC15A4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC15A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTGTATGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC15A4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC15A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC15A4

    SOURCE GeneReport for Unigene cluster: Hs.507260

    UniProtKB/Swiss-Prot: S15A4_HUMAN, Q8N697
    Tissue specificity: Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly
    expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells.
    Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum,
    jejunum, ileum and colon

        SABiosciences Custom PCR Arrays for SLC15A4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A4

    Orthologs
    for SLC15A4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC15A4 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc15a41 , 5 solute carrier family 15, member 41, 5 84.49(n)1
    88.59(a)1    		   5 (66.00 cM)5
    1005611  NM_133895.11  NP_598656.11 
     1275956645 
    chicken
    (Gallus gallus)    		 Aves SLC15A41 solute carrier family 15, member 4 76.53(n)
    80.21(a)    		   416808  XM_415099.3  XP_415099.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC15A46
    		 --
    		 67(a)
    		 1 ↔ 1
    		 LGb(526496-552867)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.258752 Xenopus laevis transcribed sequence with weak similarity more 74.57(n)    BX845641.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc564842 similar to peptide/histidine transporter 78.89(n)   393932  BC049320.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G622001 putative peptide/nitrate transporter 45.37(n)
    33.47(a)    		   842516  NM_104901.2  NP_176411.2 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 30)    		 PTR-like peptide transporter, putatuve
    (see all 30)    		 9(a)
    28(a)
    (see all 30)    		 many ↔ many
    many ↔ many
    (see all 30)    		 6(29813605-29820248)
    10(679075-682303)


    ENSEMBL Gene Tree for SLC15A4 (if available)
    TreeFam Gene Tree for SLC15A4 (if available) 

    Paralogs
    for SLC15A4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC15A4 gene
    SLC15A22  SLC15A12  SLC15A52  SLC15A32  
    1 SIMAP similar gene for SLC15A4 using alignment to 4 protein entries:     S15A4_HUMAN (see all proteins):
    SLC15A3

    SLC15A4 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC15A4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/723 NCBI SNPs in SLC15A4 are shown (see all 723)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs123701941,2
    		C,F,A,H,--129277250(+) ACACCA/TTGGGT 1 -- ds500116Minor allele frequency- T:0.49NS EA NA WA CSA 1052
    rs1822168851,2
    		--129277270(+) ATGTGA/TTATAT 1 -- ds50010--------
    rs1863066791,2
    		--129277272(+) GTGATA/GTATCC 1 -- ds50010--------
    rs1454924901,2
    		--129277311(+) TGGTAC/TCCTTC 1 -- ds50010--------
    rs1904706451,2
    		--129277373(+) AACTCC/TGGCCC 1 -- ds50010--------
    rs1144823431,2
    		C,F,--129277462(+) TTCTAT/CAGTTT 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1383071391,2
    		--129277463(+) TCTATA/GGTTTT 1 -- ds50010--------
    rs1817141121,2
    		--129277475(+) CTATAA/CTTTCT 1 -- ds50010--------
    rs123051421,2
    		C,F,A,H,--129277490(+) CACAAC/TGAACA 1 -- ds500123Minor allele frequency- T:0.13NS EA NA 2546
    rs1502199161,2
    		--129277589(+) CGCGCC/TGGAGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC15A4 (129277739 - 129308541 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLC15A4
         2 CNVs: 101644 3900
    Human Gene Mutation Database (HGMD): SLC15A4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC15A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC15A4

    Disorders / Diseases
    for SLC15A4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC15A4 for disorders           About GeneDecksing

    4 diseases for SLC15A4:    About MalaCards
    cri-du-chat syndrome    systemic lupus erythematosus    lupus erythematosus    retinitis

    1 disease from the University of Copenhagen DISEASES database for SLC15A4:
    Cri-Du-Chat syndrome
    Human Genome Epidemiology (HuGE) Navigator: SLC15A4 (5 documents)

    Export disorders for SLC15A4 gene to outside databases

    Publications
    for SLC15A4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC15A4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SLC15A4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PubMed id 11741232)1, 2, 3 Botka C.W.... Sadee W. (2000)
    2. The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells. (PubMed id 16289537)1, 2 Bhardwaj R.K.... Knipp G.T. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PubMed id 12905028)1, 9 Daniel H. and Kottra G. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential. (PubMed id 21366347)1 Agu R....Massoud E. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    10. TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associate d with clinical features of systemic lupus erythematosus in a Chinese Han popul ation. (PubMed id 20516000)1 He C.F....Yang S. (2010)

    External Searches for SLC15A4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SLC15A4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 121260 HGNC: 23090 AceView: SLC15A4 Ensembl:ENSG00000139370 euGenes: HUgn121260
    ECgene: SLC15A4 H-InvDB: SLC15A4

    Other Databases showing SLC15A4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC15A4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC15A4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC15A4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC15A4 gene:
    Search GeneIP for patents involving SLC15A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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