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Aliases for SLC15A4 Gene

Aliases for SLC15A4 Gene

  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 4 2 3
  • Solute Carrier Family 15, Member 4 2 3
  • Peptide/Histidine Transporter 1 3 4
  • Peptide Transporter 4 3 4
  • HPHT1 3 4
  • PHT1 3 4
  • PTR4 3 4
  • Peptide-Histidine Transporter 4 3
  • FP12591 3

External Ids for SLC15A4 Gene

Previous GeneCards Identifiers for SLC15A4 Gene

  • GC12M129016
  • GC12M127630
  • GC12M127802
  • GC12M129277
  • GC12M126263

Summaries for SLC15A4 Gene

GeneCards Summary for SLC15A4 Gene

SLC15A4 (Solute Carrier Family 15 (Oligopeptide Transporter), Member 4) is a Protein Coding gene. Diseases associated with SLC15A4 include cri-du-chat syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and L-histidine transmembrane transporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot for SLC15A4 Gene

  • Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A4 Gene

Genomics for SLC15A4 Gene

Regulatory Elements for SLC15A4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC15A4 Gene

Chromosome:
12
Start:
128,793,191 bp from pter
End:
128,823,996 bp from pter
Size:
30,806 bases
Orientation:
Minus strand

Genomic View for SLC15A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC15A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A4 Gene

Proteins for SLC15A4 Gene

  • Protein details for SLC15A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N697-S15A4_HUMAN
    Recommended name:
    Solute carrier family 15 member 4
    Protein Accession:
    Q8N697
    Secondary Accessions:
    • A6H8Y9
    • B3KTK1
    • Q71M34
    • Q7Z5F8
    • Q8TAH0

    Protein attributes for SLC15A4 Gene

    Size:
    577 amino acids
    Molecular mass:
    62034 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI46804.1; Type=Frameshift; Positions=342; Evidence={ECO:0000305}; Sequence=AAK95565.1; Type=Frameshift; Positions=572; Evidence={ECO:0000305}; Sequence=AAQ04807.1; Type=Frameshift; Positions=497; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC15A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC15A4 Gene

Proteomics data for SLC15A4 Gene at MOPED

Post-translational modifications for SLC15A4 Gene

  • Ubiquitination at Lys 272 and Lys 292
  • Glycosylation at Asn 140
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC15A4

No data available for DME Specific Peptides for SLC15A4 Gene

Domains & Families for SLC15A4 Gene

Gene Families for SLC15A4 Gene

Protein Domains for SLC15A4 Gene

Suggested Antigen Peptide Sequences for SLC15A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N697

UniProtKB/Swiss-Prot:

S15A4_HUMAN :
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A4: view

Function for SLC15A4 Gene

Molecular function for SLC15A4 Gene

UniProtKB/Swiss-Prot Function:
Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.

Gene Ontology (GO) - Molecular Function for SLC15A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC15A4: view

Phenotypes for SLC15A4 Gene

MGI mutant phenotypes for SLC15A4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLC15A4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC15A4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC15A4 Gene

Localization for SLC15A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC15A4 Gene COMPARTMENTS Subcellular localization image for SLC15A4 gene
Compartment Confidence
lysosome 4
vacuole 4
nucleus 2
plasma membrane 2
endosome 1

Gene Ontology (GO) - Cellular Components for SLC15A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC15A4: view

Pathways & Interactions for SLC15A4 Gene

genes like me logo Genes that share pathways with SLC15A4: view

Interacting Proteins for SLC15A4 Gene

Gene Ontology (GO) - Biological Process for SLC15A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport IEA --
GO:0015031 protein transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC15A4: view

No data available for SIGNOR curated interactions for SLC15A4 Gene

Drugs & Compounds for SLC15A4 Gene

(2) Drugs for SLC15A4 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]histidine Pharma 0
[<sup>3</sup>H]histidine Pharma 0
genes like me logo Genes that share compounds with SLC15A4: view

Transcripts for SLC15A4 Gene

Unigene Clusters for SLC15A4 Gene

Solute carrier family 15, member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC15A4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A4 Gene

No ASD Table

Relevant External Links for SLC15A4 Gene

GeneLoc Exon Structure for
SLC15A4
ECgene alternative splicing isoforms for
SLC15A4

Expression for SLC15A4 Gene

mRNA expression in normal human tissues for SLC15A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A4 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for SLC15A4 Gene

This gene is overexpressed in Liver, secretome (23.4), NK cells (13.8), Monocytes (11.1), and Blymphocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC15A4 Gene



SOURCE GeneReport for Unigene cluster for SLC15A4 Gene Hs.507260

mRNA Expression by UniProt/SwissProt for SLC15A4 Gene

Q8N697-S15A4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon.
genes like me logo Genes that share expression patterns with SLC15A4: view

Protein tissue co-expression partners for SLC15A4 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC15A4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC15A4 35
  • 85.8 (n)
  • 87.52 (a)
SLC15A4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC15A4 35
  • 85.39 (n)
  • 86.94 (a)
SLC15A4 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc15a4 35
  • 83.84 (n)
  • 87.7 (a)
Slc15a4 16
Slc15a4 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC15A4 35
  • 98.79 (n)
  • 98.79 (a)
SLC15A4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc15a4 35
  • 83.72 (n)
  • 88.19 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC15A4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC15A4 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC15A4 35
  • 77.49 (n)
  • 81.16 (a)
SLC15A4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC15A4 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a4 35
  • 70.48 (n)
  • 76.15 (a)
Str.1385 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25875 35
zebrafish
(Danio rerio)
Actinopterygii slc15a4 35
  • 65.06 (n)
  • 66.24 (a)
zgc56484 35
slc15a4 36
  • 65 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 36
  • 23 (a)
OneToMany
PTR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62200 35
  • 45.01 (n)
  • 33.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
OneToMany
Species with no ortholog for SLC15A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC15A4 Gene

ENSEMBL:
Gene Tree for SLC15A4 (if available)
TreeFam:
Gene Tree for SLC15A4 (if available)

Paralogs for SLC15A4 Gene

Paralogs for SLC15A4 Gene

(1) SIMAP similar genes for SLC15A4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC15A4: view

Variants for SLC15A4 Gene

Sequence variations from dbSNP and Humsavar for SLC15A4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11418 -- 128,793,558(-) TCTTT(C/T)TTAAG utr-variant-3-prime, nc-transcript-variant
rs900981 -- 128,819,706(+) ACAGC(A/G)TTACG intron-variant
rs900982 -- 128,819,824(+) TAACC(A/G)AGCAC intron-variant
rs959987 -- 128,808,255(+) GCATT(C/T)GTTCT intron-variant
rs959988 -- 128,808,049(+) CTTTT(A/C)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A4 Gene

Variant ID Type Subtype PubMed ID
dgv532e1 CNV Complex 17122850
nsv832549 CNV Loss 17160897
nsv899618 CNV Gain 21882294
nsv899619 CNV Gain 21882294
esv2746668 CNV Deletion 23290073
esv2573129 CNV Insertion 19546169
nsv53683 CNV Insertion 16902084
esv998080 CNV Insertion 20482838
nsv826541 CNV Loss 20364138
nsv899620 CNV Gain 21882294

Variation tolerance for SLC15A4 Gene

Residual Variation Intolerance Score: 34.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC15A4 Gene

HapMap Linkage Disequilibrium report
SLC15A4
Human Gene Mutation Database (HGMD)
SLC15A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A4 Gene

Disorders for SLC15A4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC15A4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cri-du-chat syndrome
  • 5p partial monosomy syndrome
- elite association

Relevant External Links for SLC15A4

Genetic Association Database (GAD)
SLC15A4
Human Genome Epidemiology (HuGE) Navigator
SLC15A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC15A4
genes like me logo Genes that share disorders with SLC15A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A4 Gene

Publications for SLC15A4 Gene

  1. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PMID: 12905028) Daniel H. … Kottra G. (Pflugers Arch. 2004) 23 67
  2. Current perspectives on established and putative mammalian oligopeptide transporters. (PMID: 12661057) Herrera-Ruiz D. … Knipp G.T. (J Pharm Sci 2003) 23 67
  3. Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes. (PMID: 14567629) Ocheltree S.M. … Smith D.E. (Pharm. Res. 2003) 23 67
  4. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PMID: 11741232) Botka C.W. … Sadee W. (AAPS PharmSci 2000) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for SLC15A4 Gene

Sources for SLC15A4 Gene

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