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Aliases for SLC15A4 Gene

Aliases for SLC15A4 Gene

  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 4 2 3
  • Solute Carrier Family 15, Member 4 2 3
  • Peptide/Histidine Transporter 1 3 4
  • Peptide Transporter 4 3 4
  • HPHT1 3 4
  • PHT1 3 4
  • PTR4 3 4
  • Solute Carrier Family 15 Member 4 3
  • Peptide-Histidine Transporter 4 3
  • FP12591 3

External Ids for SLC15A4 Gene

Previous GeneCards Identifiers for SLC15A4 Gene

  • GC12M129016
  • GC12M127630
  • GC12M127802
  • GC12M129277
  • GC12M126263

Summaries for SLC15A4 Gene

GeneCards Summary for SLC15A4 Gene

SLC15A4 (Solute Carrier Family 15 (Oligopeptide Transporter), Member 4) is a Protein Coding gene. Diseases associated with SLC15A4 include cri-du-chat syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity and L-histidine transmembrane transporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot for SLC15A4 Gene

  • Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A4 Gene

Genomics for SLC15A4 Gene

Regulatory Elements for SLC15A4 Gene

Genomic Location for SLC15A4 Gene

128,793,191 bp from pter
128,823,996 bp from pter
30,806 bases
Minus strand

Genomic View for SLC15A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC15A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A4 Gene

Proteins for SLC15A4 Gene

  • Protein details for SLC15A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 15 member 4
    Protein Accession:
    Secondary Accessions:
    • A6H8Y9
    • B3KTK1
    • Q71M34
    • Q7Z5F8
    • Q8TAH0

    Protein attributes for SLC15A4 Gene

    577 amino acids
    Molecular mass:
    62034 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI46804.1; Type=Frameshift; Positions=342; Evidence={ECO:0000305}; Sequence=AAK95565.1; Type=Frameshift; Positions=572; Evidence={ECO:0000305}; Sequence=AAQ04807.1; Type=Frameshift; Positions=497; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC15A4 Gene


neXtProt entry for SLC15A4 Gene

Proteomics data for SLC15A4 Gene at MOPED

Post-translational modifications for SLC15A4 Gene

  • Ubiquitination at Lys272 and Lys292
  • Glycosylation at Asn140
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC15A4 Gene

Domains for SLC15A4 Gene

Gene Families for SLC15A4 Gene

Protein Domains for SLC15A4 Gene

Suggested Antigen Peptide Sequences for SLC15A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N697
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A4: view

Function for SLC15A4 Gene

Molecular function for SLC15A4 Gene

UniProtKB/Swiss-Prot Function: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.

Gene Ontology (GO) - Molecular Function for SLC15A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005290 L-histidine transmembrane transporter activity IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC15A4: view

Phenotypes for SLC15A4 Gene

MGI mutant phenotypes for SLC15A4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SLC15A4: view

miRNA for SLC15A4 Gene

miRTarBase miRNAs that target SLC15A4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC15A4 Gene

Localization for SLC15A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC15A4 Gene COMPARTMENTS Subcellular localization image for SLC15A4 gene
Compartment Confidence
lysosome 4
vacuole 4
plasma membrane 3
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC15A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC15A4: view

Pathways for SLC15A4 Gene

genes like me logo Genes that share pathways with SLC15A4: view

Interacting Proteins for SLC15A4 Gene

Gene Ontology (GO) - Biological Process for SLC15A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport IEA --
GO:0015031 protein transport IEA --
GO:0015817 histidine transport --
genes like me logo Genes that share ontologies with SLC15A4: view

Compounds for SLC15A4 Gene

(2) IUPHAR Ligand for SLC15A4 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]histidine None None
[14C]histidine None None
genes like me logo Genes that share compounds with SLC15A4: view

Transcripts for SLC15A4 Gene

Unigene Clusters for SLC15A4 Gene

Solute carrier family 15, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A4 Gene

No ASD Table

Relevant External Links for SLC15A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC15A4 Gene

mRNA expression in normal human tissues for SLC15A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A4 Gene

This gene is overexpressed in Whole Blood (6.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC15A4 Gene

SOURCE GeneReport for Unigene cluster for SLC15A4 Gene Hs.507260

mRNA Expression by UniProt/SwissProt for SLC15A4 Gene

Tissue specificity: Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon.
genes like me logo Genes that share expressions with SLC15A4: view

Orthologs for SLC15A4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC15A4 35
  • 98.79 (n)
  • 98.79 (a)
SLC15A4 36
  • 99 (a)
(Bos Taurus)
Mammalia SLC15A4 35
  • 85.8 (n)
  • 87.52 (a)
SLC15A4 36
  • 86 (a)
(Canis familiaris)
Mammalia SLC15A4 35
  • 85.39 (n)
  • 86.94 (a)
SLC15A4 36
  • 63 (a)
(Mus musculus)
Mammalia Slc15a4 35
  • 83.84 (n)
  • 87.7 (a)
Slc15a4 16
Slc15a4 36
  • 86 (a)
(Monodelphis domestica)
Mammalia SLC15A4 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SLC15A4 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Slc15a4 35
  • 83.72 (n)
  • 88.19 (a)
(Gallus gallus)
Aves SLC15A4 35
  • 77.49 (n)
  • 81.16 (a)
SLC15A4 36
  • 78 (a)
(Anolis carolinensis)
Reptilia SLC15A4 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25875 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a4 35
  • 70.48 (n)
  • 76.15 (a)
Str.1385 35
(Danio rerio)
Actinopterygii slc15a4 35
  • 65.06 (n)
  • 66.24 (a)
slc15a4 36
  • 65 (a)
zgc56484 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 36
  • 23 (a)
PTR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62200 35
  • 45.01 (n)
  • 33.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
Species with no ortholog for SLC15A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC15A4 Gene

Gene Tree for SLC15A4 (if available)
Gene Tree for SLC15A4 (if available)

Paralogs for SLC15A4 Gene

Paralogs for SLC15A4 Gene

Selected SIMAP similar genes for SLC15A4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC15A4: view

Variants for SLC15A4 Gene

Sequence variations from dbSNP and Humsavar for SLC15A4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11418 -- 128,793,558(-) TCTTT(C/T)TTAAG utr-variant-3-prime
rs900981 -- 128,819,706(+) ACAGC(A/G)TTACG intron-variant
rs900982 -- 128,819,824(+) TAACC(A/G)AGCAC intron-variant
rs959987 -- 128,808,255(+) GCATT(C/T)GTTCT intron-variant
rs959988 -- 128,808,049(+) CTTTT(A/C)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A4 Gene

Variant ID Type Subtype PubMed ID
dgv532e1 CNV Complex 17122850
nsv832549 CNV Loss 17160897
nsv899618 CNV Gain 21882294
nsv899619 CNV Gain 21882294
esv2746668 CNV Deletion 23290073
esv2573129 CNV Insertion 19546169
nsv53683 CNV Insertion 16902084
esv998080 CNV Insertion 20482838
nsv826541 CNV Loss 20364138
nsv899620 CNV Gain 21882294

Relevant External Links for SLC15A4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A4 Gene

Disorders for SLC15A4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC15A4 Gene including...

Search for SLC15A4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC15A4 Gene

Relevant External Links for SLC15A4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC15A4: view

No data available for UniProtKB/Swiss-Prot for SLC15A4 Gene

Publications for SLC15A4 Gene

  1. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PMID: 11741232) Botka C.W. … Sadee W. (AAPS PharmSci 2000) 2 3 4
  2. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PMID: 12905028) Daniel H. … Kottra G. (Pflugers Arch. 2004) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells. (PMID: 16289537) Bhardwaj R.K. … Knipp G.T. (Eur. J. Pharm. Sci. 2006) 3 4
  5. Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. (PMID: 18259684) Takeuchi F. … Kato N. (J. Hum. Genet. 2008) 3 48

Products for SLC15A4 Gene

  • antibodies-online peptides for SLC15A4
  • antibodies-online antibodies for SLC15A4
  • antibodies-online kits for SLC15A4

Sources for SLC15A4 Gene

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