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Aliases for SLC15A3 Gene

Aliases for SLC15A3 Gene

  • Solute Carrier Family 15 Member 3 2 3
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 3 2 3 5
  • Solute Carrier Family 15, Member 3 2 3
  • Peptide/Histidine Transporter 2 3 4
  • Osteoclast Transporter 3 4
  • Peptide Transporter 3 3 4
  • OCTP 3 4
  • PHT2 3 4
  • PTR3 3 4

External Ids for SLC15A3 Gene

Previous GeneCards Identifiers for SLC15A3 Gene

  • GC11M060480
  • GC11M060481
  • GC11M060461
  • GC11M060704
  • GC11M057050

Summaries for SLC15A3 Gene

GeneCards Summary for SLC15A3 Gene

SLC15A3 (Solute Carrier Family 15 Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A4.

UniProtKB/Swiss-Prot for SLC15A3 Gene

  • Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A3 Gene

Genomics for SLC15A3 Gene

Regulatory Elements for SLC15A3 Gene

Promoters for SLC15A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC15A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC15A3 Gene

Chromosome:
11
Start:
60,937,083 bp from pter
End:
60,952,530 bp from pter
Size:
15,448 bases
Orientation:
Minus strand

Genomic View for SLC15A3 Gene

Genes around SLC15A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A3 Gene

Proteins for SLC15A3 Gene

  • Protein details for SLC15A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY34-S15A3_HUMAN
    Recommended name:
    Solute carrier family 15 member 3
    Protein Accession:
    Q8IY34
    Secondary Accessions:
    • Q9P2X9

    Protein attributes for SLC15A3 Gene

    Size:
    581 amino acids
    Molecular mass:
    63560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A3 Gene

Proteomics data for SLC15A3 Gene at MOPED

Post-translational modifications for SLC15A3 Gene

  • Glycosylation at Asn 61, Asn 66, Asn 178, Asn 223, Asn 356, and Asn 439
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC15A3 Gene

Domains & Families for SLC15A3 Gene

Gene Families for SLC15A3 Gene

Protein Domains for SLC15A3 Gene

Suggested Antigen Peptide Sequences for SLC15A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY34

UniProtKB/Swiss-Prot:

S15A3_HUMAN :
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A3: view

Function for SLC15A3 Gene

Molecular function for SLC15A3 Gene

UniProtKB/Swiss-Prot Function:
Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).

Gene Ontology (GO) - Molecular Function for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with SLC15A3: view
genes like me logo Genes that share phenotypes with SLC15A3: view

Animal Models for SLC15A3 Gene

MGI Knock Outs for SLC15A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC15A3

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC15A3 Gene

Localization for SLC15A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A3 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC15A3 Gene COMPARTMENTS Subcellular localization image for SLC15A3 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC15A3: view

Pathways & Interactions for SLC15A3 Gene

genes like me logo Genes that share pathways with SLC15A3: view

Interacting Proteins for SLC15A3 Gene

Gene Ontology (GO) - Biological Process for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA,TAS --
genes like me logo Genes that share ontologies with SLC15A3: view

No data available for SIGNOR curated interactions for SLC15A3 Gene

Drugs & Compounds for SLC15A3 Gene

(2) Drugs for SLC15A3 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]histidine Pharma 0
[<sup>3</sup>H]histidine Pharma 0
genes like me logo Genes that share compounds with SLC15A3: view

Transcripts for SLC15A3 Gene

Unigene Clusters for SLC15A3 Gene

Solute carrier family 15, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for SLC15A3 Gene

GeneLoc Exon Structure for
SLC15A3
ECgene alternative splicing isoforms for
SLC15A3

Expression for SLC15A3 Gene

mRNA expression in normal human tissues for SLC15A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A3 Gene

This gene is overexpressed in Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for SLC15A3 Gene

This gene is overexpressed in Spleen (30.7), Monocytes (27.6), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC15A3 Gene



SOURCE GeneReport for Unigene cluster for SLC15A3 Gene Hs.237856

genes like me logo Genes that share expression patterns with SLC15A3: view

Protein tissue co-expression partners for SLC15A3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC15A3 Gene

Orthologs for SLC15A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC15A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC15A3 35
  • 85.89 (n)
  • 82.44 (a)
SLC15A3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc15a3 35
  • 81.66 (n)
  • 81.14 (a)
Slc15a3 16
Slc15a3 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC15A3 35
  • 98.86 (n)
  • 98.79 (a)
SLC15A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc15a3 35
  • 81.15 (n)
  • 81.21 (a)
dog
(Canis familiaris)
Mammalia SLC15A3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC15A3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC15A3 36
  • 62 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for SLC15A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC15A3 Gene

ENSEMBL:
Gene Tree for SLC15A3 (if available)
TreeFam:
Gene Tree for SLC15A3 (if available)

Paralogs for SLC15A3 Gene

Paralogs for SLC15A3 Gene

(1) SIMAP similar genes for SLC15A3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC15A3: view

Variants for SLC15A3 Gene

Sequence variations from dbSNP and Humsavar for SLC15A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17855607 - 60,942,097(+) GAAAA(A/T)GTTTG nc-transcript-variant, reference, missense
rs121435 -- 60,940,440(-) GTATG(A/T)GCTGG intron-variant
rs485639 -- 60,945,200(-) GTCGT(A/G)TGAGG intron-variant
rs517805 -- 60,943,974(-) CATCA(C/T)CTTGG intron-variant
rs487104 -- 60,947,169(-) TAGGT(G/T)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A3 Gene

Variant ID Type Subtype PubMed ID
nsv897599 CNV Loss 21882294
nsv897600 CNV Gain 21882294
nsv897601 CNV Loss 21882294

Variation tolerance for SLC15A3 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC15A3 Gene

HapMap Linkage Disequilibrium report
SLC15A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A3 Gene

Disorders for SLC15A3 Gene

Relevant External Links for SLC15A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC15A3

No disorders were found for SLC15A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC15A3 Gene

Publications for SLC15A3 Gene

  1. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4 67
  2. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PMID: 12905028) Daniel H. … Kottra G. (Pflugers Arch. 2004) 3 23
  3. Cloning of a lymphatic peptide/histidine transporter. (PMID: 11336635) Sakata K. … Tohyama M. (Biochem. J. 2001) 2 3
  4. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PMID: 11741232) Botka C.W. … Sadee W. (AAPS PharmSci 2000) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SLC15A3 Gene

Sources for SLC15A3 Gene

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