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Aliases for SLC15A3 Gene

Aliases for SLC15A3 Gene

  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 3 2 3
  • Solute Carrier Family 15, Member 3 2 3
  • Peptide/Histidine Transporter 2 3 4
  • Osteoclast Transporter 3 4
  • Peptide Transporter 3 3 4
  • OCTP 3 4
  • PHT2 3 4
  • PTR3 3 4
  • Solute Carrier Family 15 Member 3 3

External Ids for SLC15A3 Gene

Summaries for SLC15A3 Gene

GeneCards Summary for SLC15A3 Gene

SLC15A3 (Solute Carrier Family 15 (Oligopeptide Transporter), Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC15A4.

UniProtKB/Swiss-Prot for SLC15A3 Gene

  • Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A3 Gene

Genomics for SLC15A3 Gene

Genomic Location for SLC15A3 Gene

Start:
60,937,083 bp from pter
End:
60,952,530 bp from pter
Size:
15,448 bases
Orientation:
Minus strand

Genomic View for SLC15A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC15A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A3 Gene

Regulatory Elements for SLC15A3 Gene

Proteins for SLC15A3 Gene

  • Protein details for SLC15A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY34-S15A3_HUMAN
    Recommended name:
    Solute carrier family 15 member 3
    Protein Accession:
    Q8IY34
    Secondary Accessions:
    • Q9P2X9

    Protein attributes for SLC15A3 Gene

    Size:
    581 amino acids
    Molecular mass:
    63560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A3 Gene

Proteomics data for SLC15A3 Gene at MOPED

Post-translational modifications for SLC15A3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn61, Asn66, Asn178, Asn223, Asn356, and Asn439

Other Protein References for SLC15A3 Gene

No data available for DME Specific Peptides for SLC15A3 Gene

Domains for SLC15A3 Gene

Gene Families for SLC15A3 Gene

Protein Domains for SLC15A3 Gene

Suggested Antigen Peptide Sequences for SLC15A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY34

UniProtKB/Swiss-Prot:

S15A3_HUMAN
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.:
    • Q8IY34
genes like me logo Genes that share domains with SLC15A3: view

Function for SLC15A3 Gene

Molecular function for SLC15A3 Gene

UniProtKB/Swiss-Prot Function: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).

Gene Ontology (GO) - Molecular Function for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC15A3: view

Phenotypes for SLC15A3 Gene

GenomeRNAi human phenotypes for SLC15A3:
genes like me logo Genes that share phenotypes with SLC15A3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC15A3 Gene

Localization for SLC15A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A3 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC15A3 Gene COMPARTMENTS Subcellular localization image for SLC15A3 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3
chloroplast 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SLC15A3: view

Pathways for SLC15A3 Gene

genes like me logo Genes that share pathways with SLC15A3: view

Interacting Proteins for SLC15A3 Gene

Gene Ontology (GO) - Biological Process for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC15A3: view

Compounds for SLC15A3 Gene

(2) IUPHAR Ligand for SLC15A3 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]histidine None None
[14C]histidine None None
genes like me logo Genes that share compounds with SLC15A3: view

Transcripts for SLC15A3 Gene

Unigene Clusters for SLC15A3 Gene

Solute carrier family 15, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for SLC15A3 Gene

GeneLoc Exon Structure for
SLC15A3
ECgene alternative splicing isoforms for
SLC15A3

Expression for SLC15A3 Gene

mRNA expression in normal human tissues for SLC15A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A3 Gene

This gene is overexpressed in Whole Blood (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC15A3 Gene

SOURCE GeneReport for Unigene cluster for SLC15A3 Gene Hs.237856

genes like me logo Genes that share expressions with SLC15A3: view

No data available for mRNA Expression by UniProt/SwissProt for SLC15A3 Gene

Orthologs for SLC15A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC15A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A3 35
  • 98.86 (n)
  • 98.79 (a)
SLC15A3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC15A3 35
  • 85.89 (n)
  • 82.44 (a)
SLC15A3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC15A3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc15a3 35
  • 81.66 (n)
  • 81.14 (a)
Slc15a3 16
Slc15a3 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC15A3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc15a3 35
  • 81.15 (n)
  • 81.21 (a)
lizard
(Anolis carolinensis)
Reptilia SLC15A3 36
  • 62 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for SLC15A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC15A3 Gene

ENSEMBL:
Gene Tree for SLC15A3 (if available)
TreeFam:
Gene Tree for SLC15A3 (if available)

Paralogs for SLC15A3 Gene

Paralogs for SLC15A3 Gene

Selected SIMAP similar genes for SLC15A3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC15A3: view

Variants for SLC15A3 Gene

Sequence variations from dbSNP and Humsavar for SLC15A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs121435 -- 60,940,440(-) GTATG(A/T)GCTGG intron-variant
rs485639 -- 60,945,200(-) GTCGT(A/G)TGAGG intron-variant
rs487104 -- 60,947,169(-) TAGGT(G/T)GCTCA intron-variant
rs510261 -- 60,940,373(-) TTTAT(C/T)CCAGC intron-variant
rs515587 -- 60,939,771(-) TCCAG(C/T)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A3 Gene

Variant ID Type Subtype PubMed ID
nsv897599 CNV Loss 21882294
nsv897600 CNV Gain 21882294
nsv897601 CNV Loss 21882294

Relevant External Links for SLC15A3 Gene

HapMap Linkage Disequilibrium report
SLC15A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A3 Gene

Disorders for SLC15A3 Gene

No disorders were found for SLC15A3 Gene.

No data available for UniProtKB/Swiss-Prot for SLC15A3 Gene

Publications for SLC15A3 Gene

  1. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PMID: 12905028) Daniel H. … Kottra G. (Pflugers Arch. 2004) 3 23
  2. Cloning of a lymphatic peptide/histidine transporter. (PMID: 11336635) Sakata K. … Tohyama M. (Biochem. J. 2001) 2 3
  3. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PMID: 11741232) Botka C.W. … Sadee W. (AAPS PharmSci 2000) 2 3
  4. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3

Products for SLC15A3 Gene

Sources for SLC15A3 Gene

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