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SLC15A2 Gene

protein-coding   GIFtS: 58
GCID: GC03P121612

Solute Carrier Family 15 (Oligopeptide Transporter), Member...

(Previous names: solute carrier family 15 (H+/peptide transporter), member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 15 (Oligopeptide Transporter), Member 21 2     Oligopeptide Transporter, Kidney Isoform2 3
PEPT22 3 5     Peptide Transporter 22 3
Solute Carrier Family 15 (H+/Peptide Transporter), Member 21 2     Solute Carrier Family 15 Member 22
Kidney H(+)/Peptide Cotransporter2 3     

External Ids:    HGNC: 109211   Entrez Gene: 65652   Ensembl: ENSG000001634067   OMIM: 6023395   UniProtKB: Q163483   

Export aliases for SLC15A2 gene to outside databases

Previous GC identifers: GC03P118308 GC03P121254 GC03P122894 GC03P122934 GC03P123096 GC03P118987


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC15A2 Gene:
The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of
small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This
transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide
transporter found in the small intestine (Liu et al, 1995 (PubMed 7756356)).(supplied by OMIM, Feb 2011)

GeneCards Summary for SLC15A2 Gene:
SLC15A2 (solute carrier family 15 (oligopeptide transporter), member 2) is a protein-coding gene. Diseases associated with SLC15A2 include hyperparathyroidism, and fibrosarcoma. GO annotations related to this gene include high affinity oligopeptide transporter activity and peptide:hydrogen symporter activity. An important paralog of this gene is SLC15A1.

UniProtKB/Swiss-Prot: S15A2_HUMAN, Q16348
Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

Gene Wiki entry for SLC15A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC15A2 gene promoter:
         RFX1   CUTL1   Evi-1   NF-AT   NF-AT4   NF-AT2   FOXJ2 (long isoform)   NF-AT3   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC15A2 promoter sequence
   Search Chromatin IP Primers for SLC15A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC15A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q21.1

SLC15A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC15A2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P121612:  view genomic region     (about GC identifiers)

Start:
121,612,936 bp from pter      End:
121,663,034 bp from pter
Size:
50,099 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S15A2_HUMAN, Q16348 (See protein sequence)
Recommended Name: Solute carrier family 15 member 2  
Size: 729 amino acids; 81783 Da
Secondary accessions: A8K1A5 B4E2A7
Alternative splicing: 2 isoforms:  Q16348-1   Q16348-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC15A2: NX_Q16348

Explore proteomics data for SLC15A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn269, Asn373, Asn435, Asn472, Asn528, Asn567
  • Modification sites at PhosphoSitePlus

  • See SLC15A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139470.1  NP_066568.3  

    ENSEMBL proteins: 
     ENSP00000417085   ENSP00000295605   ENSP00000418704  
    Reactome Protein details: Q16348

    SLC15A2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Peptide transporter 2
    SLC15 family of peptide transporters

    4 InterPro protein domains:
     IPR000109 POT_fam
     IPR018456 PTR2_symporter_CS
     IPR004768 Oligopep_transport
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q16348

    ProtoNet protein and cluster: Q16348

    1 Blocks protein domain: IPB000109 TGF-beta receptor

    UniProtKB/Swiss-Prot: S15A2_HUMAN, Q16348
    Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family


    SLC15A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S15A2_HUMAN, Q16348
    Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding IPI16738539
    GO:0015198oligopeptide transporter activity ----
    GO:0015333peptide:hydrogen symporter activity TAS7756356
    GO:0015334high affinity oligopeptide transporter activity IEA--
         
    SLC15A2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc15a2):
     cellular  renal/urinary system 

    SLC15A2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC15A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC15A2
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    miRNA
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    miRTarBase miRNAs that target SLC15A2:
    hsa-mir-122-5p (MIRT023364)

    Block miRNA regulation of human, mouse, rat SLC15A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC15A2 (see all 20):
    hsa-miR-376b hsa-miR-509-5p hsa-miR-1304 hsa-miR-23a hsa-miR-3662 hsa-miR-613 hsa-miR-509-3-5p hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSLC15A2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S15A2_HUMAN, Q16348: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    SLC15A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC15A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Proton/oligonucleotide cotransporters0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC15A2
        Proton/oligonucleotide cotransporters



    SLC15A2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC15A2: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC15A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SLC15A2 (Q163483 ENSP000004170854) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    MTORP423453, ENSP000003545584I2D: score=1 STRING: ENSP00000354558
    JUNP054123I2D: score=5 
    AADATQ8N5Z03I2D: score=1 
    AMD1P177073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7756356
    GO:0006811ion transport TAS--
    GO:0006857oligopeptide transport ----
    GO:0015031protein transport IEA--
    GO:0015893drug transport NAS16738539

    SLC15A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC15A2 (S15A2)

    1 HMDB Compound for SLC15A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-011474785

    Selected DrugBank Compounds for SLC15A2 (see all 41)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CefadroxilCDX (see all 3)66592-87-8transporterinhibitor15567297 7592745 9374833 14600253
    CephalexinCefalessina [DCIT] (see all 12)15686-71-2transporterinhibitor7756356 15567297 7592745 9374833
    AmoxicillinAmoxicilina [INN-Spanish] (see all 9)26787-78-0transporterinhibitor15567297 16434549 9374833
    CefiximeCefixim (see all 4)79350-37-1transporterinhibitor15567297 9374833 9092716
    Ceftibuten-- 97519-39-6transporterinhibitor15567297 9374833 9092716
    CyclacillinAminocyclohexylpenicillin (see all 6)3485-14-1transporterinhibitor15567297 7592745 9374833
    AmpicillinAminobenzylpenicillin (see all 16)69-53-4transporterinhibitor15567297 9374833
    Azidocillin-- 17243-38-8transporterinhibitor15567297 9374833
    Bestatin-- --transportersubstrate inhibitor8639691 11007306
    CefaclorCCL (see all 4)53994-73-3transporterinhibitor15567297 16434549

    5 IUPHAR Ligands for SLC15A2 (Peptide transporter 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    [14C]GlySar
    NoneNone--
    [3H]GlySar
    NoneNone--
    [11C]GlySar
    NoneNone--
    Lys[Z(NO2)]-Pro
    InhibitorInhibition--
    Lys[Z(NO2)]-Lys[Z(NO2)]
    InhibitorInhibition16868651 11752223

    8 Novoseek inferred chemical compound relationships for SLC15A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycylsarcosine 87.6 4 10824137 (1), 16738539 (1)
    tripeptide s 83 3 15981923 (1), 12490619 (1), 12676733 (1)
    valacyclovir 71.6 4 9610386 (3), 11454935 (1)
    5-aminolevulinic acid 63.8 5 19723536 (2), 14969997 (1), 11454935 (1)
    tripeptide 54.2 1 14761208 (1)
    ganciclovir 25.3 1 10824137 (1)
    nucleoside 14.4 2 12388627 (1), 10919840 (1)
    histidine 9.63 1 11741232 (1)



    SLC15A2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC15A2 gene (2 alternative transcripts): 
    NM_001145998.1  NM_021082.3  

    Unigene Cluster for SLC15A2:

    Solute carrier family 15 (H+/peptide transporter), member 2
    Hs.518089  [show with all ESTs]
    Unigene Representative Sequence: NM_021082
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489711(uc003eep.2 uc011bjn.1) ENST00000295605 ENST00000469013
    ENST00000489886 ENST00000489957 ENST00000465060 ENST00000469422
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC15A2 (see all 20):
    hsa-miR-376b hsa-miR-509-5p hsa-miR-1304 hsa-miR-23a hsa-miR-3662 hsa-miR-613 hsa-miR-509-3-5p hsa-miR-3163
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC15A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC15A2

    Additional mRNA sequence: 

    AK090726.1 AK289820.1 AK296895.1 AK302002.1 AK304189.1 BC020743.1 BC038445.1 BC044572.1 
    S78203.1 

    8 DOTS entries:

    DT.454065  DT.99992145  DT.86847008  DT.91793816  DT.91809869  DT.95157328  DT.112154  DT.423383 

    Selected AceView cDNA sequences (see all 82):

    AW235519 BE674296 CD672337 BM978444 BX643499 NM_021082 BC038445 BF223679 
    AA166800 CF541006 AA442208 AA761113 BQ017433 CB242692 AI658911 BC044572 
    Z41935 AA425352 BQ187747 BI458503 AI745393 Z45771 Z45420 AW295922 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC15A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC15A2 Expression
    About this image


    SLC15A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    SLC15A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC15A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518089
        Pathway & Disease-focused RT2 Profiler PCR Array including SLC15A2: 
              Drug Transporters in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC15A2
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    QuantiTect SYBR Green Assays in human, mouse, rat SLC15A2
    QuantiFast Probe-based Assays in human, mouse, rat SLC15A2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC15A2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc15a21 , 5 solute carrier family 15 (H+/peptide transporter), more1, 5 85.23(n)1
    82.72(a)1
      16 (25.97 cM)5
    577381  NM_021301.31  NP_067276.21 
     367501785 
    chicken
    (Gallus gallus)
    Aves SLC15A21 solute carrier family 15 (H+/peptide transporter), more 64.92(n)
    61.43(a)
      424244  XM_422093.4  XP_422093.4 
    lizard
    (Anolis carolinensis)
    Reptilia SLC15A26
    solute carrier family 15 (oligopeptide transporter...
    59(a)
    1 ↔ 1
    1(83566958-83674940)
    African clawed frog
    (Xenopus laevis)
    Amphibia slc15a2-prov2 solute carrier family 15 (H+/peptide transporter), more 75.82(n)    BC054967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc15a21 solute carrier family 15 (H+/peptide transporter), more 61.9(n)
    57(a)
      556684  NM_001039828.1  NP_001034917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH067173 proton-dependent oligopeptide
    transporter
    42(a)
    (best of 3)
      3F4   --
    worm
    (Caenorhabditis elegans)
    Secernentea opt-13
    pept-31
    oligopeptide transporter3
    pept-31
    42(a)
    (best of 2)3
    48.75(n)1
    38.16(a)1
      IV(10790855-10794593)3
    1722981  NM_059366.51  NP_491767.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTR26
    Integral membrane peptide transporter, mediates tr...
    19(a)
    1 → many
    XI(615730-617535) YKR093W
    rice
    (Oryza sativa)
    Liliopsida Os03g02357001 Os03g0235700 46.41(n)
    35.89(a)
      4332182  NM_001056023.1  NP_001049488.1 


    ENSEMBL Gene Tree for SLC15A2 (if available)
    TreeFam Gene Tree for SLC15A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC15A2 gene
    SLC15A12  SLC15A52  SLC15A32  SLC15A42  
    3 SIMAP similar genes for SLC15A2 using alignment to 4 protein entries:     S15A2_HUMAN (see all proteins):
    hPEPT1-RF    SLC15A1    PEPT1

    SLC15A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SLC15A2 (see all 1071)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509488621,2
    --121611221(+) GCTGGA/GCTCTT 2 -- us2k10--------
    rs1407889901,2
    C--121611399(+) GAGTTA/GTAGGT 2 -- us2k10--------
    rs1861658341,2
    --121611408(+) GTTTTC/TTCTCT 2 -- us2k10--------
    rs2010114061,2
    --121611410(+) TTCTC-/AAATCTTG 2 -- cds10--------
    rs782352821,2
    C--121611500(+) CTCTCC/TAGCCT 2 -- us2k10--------
    rs1385929861,2
    --121611545(+) GGGCAA/CCATGC 2 -- us2k10--------
    rs1907849461,2
    --121611611(+) CACCTA/GGCATT 2 -- us2k10--------
    rs98776711,2
    C,H--121611619(+) ATTATC/GATGTT 2 -- us2k112Minor allele frequency- G:0.08NA WA CSA EA 374
    rs1141431531,2
    F--121611627(+) GTTTGT/CTCTTG 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1413768341,2
    --121611780(+) ATGAAA/TATATA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC15A2 (121612936 - 121663034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC15A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877383CNV Loss21882294
    esv33139CNV Loss17666407
    nsv877384CNV Gain21882294
    nsv516233CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC15A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC15A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602339    OMIM disorders: --

    9 diseases for SLC15A2:    
    About MalaCards
    hyperparathyroidism    fibrosarcoma    cystic fibrosis    choroiditis
    multiple sclerosis    prostate cancer    cerebritis    malaria
    prostatitis


    SLC15A2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC15A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung tumor 24.1 1 14969997 (1)

    Genetic Association Database (GAD): SLC15A2
    Human Genome Epidemiology (HuGE) Navigator: SLC15A2 (8 documents)

    Export disorders for SLC15A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC15A2 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with SLC15A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. (PubMed id 7756356)1, 2, 3, 7 Liu W.... Leibach F.H. (Biochim. Biophys. Acta 1995)
    2. Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. (PubMed id 18766334)1, 4, 9 Liu R....Lee E.J. (Eur. J. Clin. Pharmacol. 2009)
    3. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PubMed id 18713951)1, 7, 9 KnA1tter I....Brandsch M. (J. Pharmacol. Exp. Ther. 2008)
    4. Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure. (PubMed id 19723536)1, 4, 9 Sobin C....Alterio H. (Neurotoxicology 2009)
    5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    6. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    7. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    8. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6565 HGNC: 10921 AceView: SLC15A2 Ensembl:ENSG00000163406 euGenes: HUgn6565
    ECgene: SLC15A2 H-InvDB: SLC15A2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC15A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC15A2 gene:
    Search GeneIP for patents involving SLC15A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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