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Aliases for SLC15A2 Gene

Aliases for SLC15A2 Gene

  • Solute Carrier Family 15 Member 2 2 3 5
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 2 2 3
  • Solute Carrier Family 15 (H+/Peptide Transporter), Member 2 2 3
  • Oligopeptide Transporter, Kidney Isoform 3 4
  • Kidney H(+)/Peptide Cotransporter 3 4
  • Peptide Transporter 2 3 4
  • PEPT2 3 4

External Ids for SLC15A2 Gene

Previous GeneCards Identifiers for SLC15A2 Gene

  • GC03P118308
  • GC03P121254
  • GC03P122894
  • GC03P122934
  • GC03P123096
  • GC03P121612
  • GC03P118987

Summaries for SLC15A2 Gene

Entrez Gene Summary for SLC15A2 Gene

  • The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC15A2 Gene

SLC15A2 (Solute Carrier Family 15 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and peptide:proton symporter activity. An important paralog of this gene is SLC15A1.

UniProtKB/Swiss-Prot for SLC15A2 Gene

  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

Gene Wiki entry for SLC15A2 Gene

Additional gene information for SLC15A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A2 Gene

Genomics for SLC15A2 Gene

GeneHancer (GH) Regulatory Elements for SLC15A2 Gene

Promoters and enhancers for SLC15A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I121893 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 555.9 +0.5 510 1.6 NFIL3 HLF CEBPA CEBPB CEBPG HNF4A SLC15A2 IQCB1 EAF2 GC03P121966 GC03M121324
GH03I121994 Enhancer 1.2 FANTOM5 Ensembl ENCODE 17.8 +101.1 101067 2.3 CTCF TFAP4 BACH1 MAX SIN3A EBF1 IRF4 RAD21 POLR2A SMC3 IQCB1 SLC15A2 EAF2 CD86 HCLS1 CSTA LOC101927010 ENSG00000202388 GC03M121324 ILDR1
GH03I122002 Enhancer 1.3 FANTOM5 Ensembl ENCODE 14.7 +110.0 109974 2.9 BMI1 BATF KLF5 IRF4 EGR1 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 IQCB1 SLC15A2 CD86 ENSG00000202388 ILDR1 CSTA EAF2 HCLS1 LOC101927010 GC03M121324
GH03I121997 Enhancer 1.3 FANTOM5 Ensembl ENCODE 13.7 +104.4 104412 2.2 ZBTB21 JUN EBF1 BMI1 BATF IRF4 RELA FOSL1 ZFHX2 POLR2A SLC15A2 CD86 EAF2 ENSG00000202388 ILDR1 IQCB1 CSTA HCLS1 LOC101927010 GC03M121324
GH03I121658 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.1 -234.0 -234019 3.9 HDGF PKNOX1 ATF1 SMAD1 RB1 ZBTB40 KLF5 E2F8 ZNF207 ZNF143 HCLS1 IQCB1 SLC15A2 GOLGB1 CD86 RNU4-62P GC03M121324
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC15A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC15A2 gene promoter:

Genomic Locations for SLC15A2 Gene

Genomic Locations for SLC15A2 Gene
chr3:121,894,089-121,944,187
(GRCh38/hg38)
Size:
50,099 bases
Orientation:
Plus strand
chr3:121,612,936-121,663,034
(GRCh37/hg19)

Genomic View for SLC15A2 Gene

Genes around SLC15A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A2 Gene

Proteins for SLC15A2 Gene

  • Protein details for SLC15A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16348-S15A2_HUMAN
    Recommended name:
    Solute carrier family 15 member 2
    Protein Accession:
    Q16348
    Secondary Accessions:
    • A8K1A5
    • B4E2A7

    Protein attributes for SLC15A2 Gene

    Size:
    729 amino acids
    Molecular mass:
    81783 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC15A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC15A2 Gene

Post-translational modifications for SLC15A2 Gene

  • Glycosylation at isoforms=27, posLast=269269, posLast=373373, isoforms=2435, isoforms=2472, posLast=528528, and isoforms=2567

Other Protein References for SLC15A2 Gene

No data available for DME Specific Peptides for SLC15A2 Gene

Domains & Families for SLC15A2 Gene

Gene Families for SLC15A2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

Q16348

UniProtKB/Swiss-Prot:

S15A2_HUMAN :
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A2: view

Function for SLC15A2 Gene

Molecular function for SLC15A2 Gene

UniProtKB/Swiss-Prot Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

Phenotypes From GWAS Catalog for SLC15A2 Gene

Gene Ontology (GO) - Molecular Function for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16738539
GO:0015293 symporter activity IEA --
GO:0015333 peptide:proton symporter activity TAS --
GO:0022857 transmembrane transporter activity IEA --
GO:0035673 oligopeptide transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC15A2: view
genes like me logo Genes that share phenotypes with SLC15A2: view

Animal Models for SLC15A2 Gene

MGI Knock Outs for SLC15A2:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC15A2 Gene

Localization for SLC15A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC15A2 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7756356
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with SLC15A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC15A2 Gene

Pathways & Interactions for SLC15A2 Gene

genes like me logo Genes that share pathways with SLC15A2: view

Gene Ontology (GO) - Biological Process for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 7756356
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport IEA --
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
genes like me logo Genes that share ontologies with SLC15A2: view

No data available for SIGNOR curated interactions for SLC15A2 Gene

Drugs & Compounds for SLC15A2 Gene

(53) Drugs for SLC15A2 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amoxicillin Approved, Vet_approved Pharma Transporter, inhibitor 511
Ampicillin Approved, Vet_approved Pharma Target, Transporter, inhibitor 63
Azidocillin Approved Pharma Transporter, inhibitor 0
Benazepril Approved, Investigational Pharma Transporter, substrate 46
Cefaclor Approved Pharma Transporter, inhibitor 5

(5) Additional Compounds for SLC15A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxychlorpropamide
36892-36-1
genes like me logo Genes that share compounds with SLC15A2: view

Transcripts for SLC15A2 Gene

Unigene Clusters for SLC15A2 Gene

Solute carrier family 15 (H+/peptide transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A2 Gene

No ASD Table

Relevant External Links for SLC15A2 Gene

GeneLoc Exon Structure for
SLC15A2
ECgene alternative splicing isoforms for
SLC15A2

Expression for SLC15A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC15A2 Gene

Protein differential expression in normal tissues from HIPED for SLC15A2 Gene

This gene is overexpressed in Nasal epithelium (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC15A2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC15A2 Gene:

SLC15A2

SOURCE GeneReport for Unigene cluster for SLC15A2 Gene:

Hs.518089

Evidence on tissue expression from TISSUES for SLC15A2 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with SLC15A2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A2 Gene

Orthologs for SLC15A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A2 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia SLC15A2 33 34
  • 90.53 (n)
cow
(Bos Taurus)
Mammalia SLC15A2 34
  • 87 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc15a2 33 16 34
  • 85.23 (n)
rat
(Rattus norvegicus)
Mammalia Slc15a2 33
  • 85.14 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC15A2 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC15A2 33 34
  • 64.92 (n)
lizard
(Anolis carolinensis)
Reptilia SLC15A2 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a2 33
  • 61.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia slc15a2-prov 33
zebrafish
(Danio rerio)
Actinopterygii slc15a2 33 34
  • 61.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012154 33
  • 49.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH06717 35
  • 42 (a)
yin 35 34
  • 40 (a)
CG2930 34
  • 35 (a)
ManyToMany
CG9444 35
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea pept-3 34 33
  • 48.75 (n)
ManyToMany
opt-1 35
  • 42 (a)
opt-2 35
  • 41 (a)
pept-2 34
  • 31 (a)
ManyToMany
pept-1 34
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 34
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0235700 33
  • 46.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
Species where no ortholog for SLC15A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC15A2 Gene

ENSEMBL:
Gene Tree for SLC15A2 (if available)
TreeFam:
Gene Tree for SLC15A2 (if available)

Paralogs for SLC15A2 Gene

Paralogs for SLC15A2 Gene

(3) SIMAP similar genes for SLC15A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC15A2: view

Variants for SLC15A2 Gene

Sequence variations from dbSNP and Humsavar for SLC15A2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000101122 -- 121,915,541(+) C/G intron_variant
rs1000141095 -- 121,941,201(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000289445 -- 121,906,679(+) T/C intron_variant
rs1000361921 -- 121,912,433(+) C/T intron_variant
rs1000427025 -- 121,900,527(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A2 Gene

Variant ID Type Subtype PubMed ID
esv33139 CNV loss 17666407
nsv516233 CNV gain+loss 19592680

Variation tolerance for SLC15A2 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.04; 98.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC15A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC15A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A2 Gene

Disorders for SLC15A2 Gene

Additional Disease Information for SLC15A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC15A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC15A2 Gene

Publications for SLC15A2 Gene

  1. Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. (PMID: 7756356) Liu W … Leibach FH (Biochimica et biophysica acta 1995) 2 3 4 25 58
  2. Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. (PMID: 18766334) Liu R … Lee EJ (European journal of clinical pharmacology 2009) 3 22 44 58
  3. Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure. (PMID: 19723536) Sobin C … Alterio H (Neurotoxicology 2009) 3 22 44 58
  4. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PMID: 18713951) Knütter I … Brandsch M (The Journal of pharmacology and experimental therapeutics 2008) 3 22 25 58
  5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58

Products for SLC15A2 Gene

Sources for SLC15A2 Gene

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