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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC15A2 Gene

protein-coding   GIFtS: 56
GCID: GC03P121612

Solute Carrier Family 15 (Oligopeptide Transporter), Member...

(Previous names: solute carrier family 15 (H+/peptide transporter), member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 15 (Oligopeptide Transporter), Member 21 2     Peptide Transporter 22 3
Solute Carrier Family 15 (H+/Peptide Transporter), Member 21 2     PEPT22 3
Kidney H(+)/Peptide Cotransporter2 3     Solute Carrier Family 15 Member 22
Oligopeptide Transporter, Kidney Isoform2 3     

External Ids:    HGNC: 109211   Entrez Gene: 65652   Ensembl: ENSG000001634067   OMIM: 6023395   UniProtKB: Q163483   

Export aliases for SLC15A2 gene to outside databases

Previous GC identifers: GC03P118308 GC03P121254 GC03P122894 GC03P122934 GC03P123096 GC03P118987


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC15A2 Gene:
The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of
small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This
transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide
transporter found in the small intestine (Liu et al, 1995 (PubMed 7756356)).(supplied by OMIM, Feb 2011)

GeneCards Summary for SLC15A2 Gene: 
SLC15A2 (solute carrier family 15 (oligopeptide transporter), member 2) is a protein-coding gene. Diseases associated with SLC15A2 include fibrosarcoma, and hyperparathyroidism, and among its related super-pathways are Amino acid transport across the plasma membrane and Transmembrane transport of small molecules. GO annotations related to this gene include high affinity oligopeptide transporter activity and peptide:hydrogen symporter activity. An important paralog of this gene is SLC15A1.

UniProtKB/Swiss-Prot: S15A2_HUMAN, Q16348
Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

Gene Wiki entry for SLC15A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC15A2 gene promoter:
         RFX1   CUTL1   Evi-1   NF-AT   NF-AT4   NF-AT2   FOXJ2 (long isoform)   NF-AT3   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC15A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC15A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC15A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q21.1

SLC15A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC15A2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P121612:  view genomic region     (about GC identifiers)

Start:
121,612,936 bp from pter      End:
121,663,034 bp from pter
Size:
50,099 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S15A2_HUMAN, Q16348 (See protein sequence)
Recommended Name: Solute carrier family 15 member 2  
Size: 729 amino acids; 81783 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A8K1A5 B4E2A7
Alternative splicing: 2 isoforms:  Q16348-1   Q16348-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC15A2: NX_Q16348

Explore proteomics data for SLC15A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16348

  • SLC15A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC15A2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139470.1  NP_066568.3  

    ENSEMBL proteins: 
     ENSP00000417085   ENSP00000295605   ENSP00000418704  
    Reactome Protein details: Q16348
    Human Recombinant Protein Products for SLC15A2: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    SLC15A2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Peptide transporter 2 
    SLC15 family of peptide transporters

    4 InterPro protein domains:
     IPR018456 PTR2_symporter_CS
     IPR000109 POT_fam
     IPR004768 Oligopep_transport
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q16348

    ProtoNet protein and cluster: Q16348

    1 Blocks protein domain: IPB000109 TGF-beta receptor

    UniProtKB/Swiss-Prot: S15A2_HUMAN, Q16348
    Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family


    SLC15A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S15A2_HUMAN, Q16348
    Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding IPI16738539
    GO:0015198oligopeptide transporter activity ----
    GO:0015333peptide:hydrogen symporter activity TAS7756356
    GO:0015334high affinity oligopeptide transporter activity IEA--
         
    SLC15A2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc15a2):
     cellular  renal/urinary system 

    SLC15A2 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC15A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amino acid and oligopeptide SLC transporters
    Amino acid and oligopeptide SLC transporters0.63
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    3Proton/oligonucleotide cotransporters
    Proton/oligonucleotide cotransporters

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SLC15A2
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides
    Proton/oligonucleotide cotransporters



    SLC15A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC15A2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/15 Interacting proteins for SLC15A2 (Q163483 ENSP000004170854) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    JUNP054123I2D: score=5 
    AADATQ8N5Z03I2D: score=1 
    AMD1P177073I2D: score=1 
    CBSP355203I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7756356
    GO:0006811ion transport TAS--
    GO:0006857oligopeptide transport ----
    GO:0015031protein transport IEA--
    GO:0015893drug transport NAS16738539

    SLC15A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC15A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC15A2 (S15A2)

    1 HMDB Compound for SLC15A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-011474785

    10/41 DrugBank Compounds for SLC15A2 (see all 41)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CefadroxilCDX (see all 3)66592-87-8transporterinhibitor15567297 7592745 9374833 14600253
    CephalexinCefalessina [DCIT] (see all 12)15686-71-2transporterinhibitor7756356 15567297 7592745 9374833
    AmoxicillinAmoxicilina [INN-Spanish] (see all 9)26787-78-0transporterinhibitor15567297 16434549 9374833
    CefiximeCefixim (see all 4)79350-37-1transporterinhibitor15567297 9374833 9092716
    Ceftibuten-- 97519-39-6transporterinhibitor15567297 9374833 9092716
    CyclacillinAminocyclohexylpenicillin (see all 6)3485-14-1transporterinhibitor15567297 7592745 9374833
    AmpicillinAminobenzylpenicillin (see all 16)69-53-4transporterinhibitor15567297 9374833
    Azidocillin-- 17243-38-8transporterinhibitor15567297 9374833
    Bestatin-- --transportersubstrate inhibitor8639691 11007306
    CefaclorCCL (see all 4)53994-73-3transporterinhibitor15567297 16434549

    5 IUPHAR Ligands for SLC15A2 (Peptide transporter 2)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [14C]GlySar
    NoneNone--
    [3H]GlySar
    NoneNone--
    [11C]GlySar
    NoneNone--
    Lys[Z(NO2)]-Pro
    InhibitorInhibition--
    Lys[Z(NO2)]-Lys[Z(NO2)]
    InhibitorInhibition16868651 11752223

    8 Novoseek inferred chemical compound relationships for SLC15A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycylsarcosine 87.6 4 10824137 (1), 16738539 (1)
    tripeptide s 83 3 15981923 (1), 12490619 (1), 12676733 (1)
    valacyclovir 71.6 4 9610386 (3), 11454935 (1)
    5-aminolevulinic acid 63.8 5 19723536 (2), 14969997 (1), 11454935 (1)
    tripeptide 54.2 1 14761208 (1)
    ganciclovir 25.3 1 10824137 (1)
    nucleoside 14.4 2 12388627 (1), 10919840 (1)
    histidine 9.63 1 11741232 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC15A2 / S15A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC15A2 gene (2 alternative transcripts): 
    NM_001145998.1  NM_021082.3  

    Unigene Cluster for SLC15A2:

    Solute carrier family 15 (H+/peptide transporter), member 2
    Hs.518089  [show with all ESTs]
    Unigene Representative Sequence: NM_021082
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489711(uc003eep.2 uc011bjn.1) ENST00000295605 ENST00000469013
    ENST00000489886 ENST00000489957 ENST00000465060 ENST00000469422
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    Additional mRNA sequence: 

    AK090726.1 AK289820.1 AK296895.1 AK302002.1 AK304189.1 BC020743.1 BC038445.1 BC044572.1 
    S78203.1 

    8 DOTS entries:

    DT.454065  DT.99992145  DT.86847008  DT.91793816  DT.91809869  DT.95157328  DT.112154  DT.423383 

    24/82 AceView cDNA sequences (see all 82):

    CB242692 AA166800 AA442208 BQ017433 BF223679 BQ187747 BX643499 AI658911 
    BC038445 NM_021082 AA425352 BE674296 Z41935 BC044572 BM978444 CD672337 
    AA761113 AW235519 CF541006 AW295922 S78203 CB243147 BI761199 AI589213 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC15A2 expression in normal human tissues (normalized intensities)      SLC15A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC15A2 Expression
    About this image


    SLC15A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See SLC15A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC15A2

    SOURCE GeneReport for Unigene cluster: Hs.518089
        SABiosciences Expression via Pathway-Focused PCR Array including SLC15A2: 
              Drug Transporters in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC15A2 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc15a21 , 5 solute carrier family 15 (H+/peptide transporter), more1, 5 85.23(n)1
    82.72(a)1
      16 (25.97 cM)5
    577381  NM_021301.31  NP_067276.21 
     367501785 
    chicken
    (Gallus gallus)
    Aves SLC15A21 solute carrier family 15 (H+/peptide transporter), more 64.92(n)
    61.43(a)
      424244  XM_422093.3  XP_422093.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC15A26
    solute carrier family 15 (H+/peptide transporter),...
    59(a)
    1 ↔ 1
    1(83566958-83674940)
    African clawed frog
    (Xenopus laevis)
    Amphibia slc15a2-prov2 solute carrier family 15 (H+/peptide transporter), more 75.82(n)    BC054967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc15a21 solute carrier family 15 (H+/peptide transporter), more 62.36(n)
    57.59(a)
      556684  NM_001039828.1  NP_001034917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH067173 proton-dependent oligopeptide
    transporter
    42(a)
    (best of 3)
      3F4   --
    worm
    (Caenorhabditis elegans)
    Secernentea opt-13
    pept-31
    oligopeptide transporter3
    Protein PEPT-31
    42(a)
    (best of 2)3
    48.75(n)1
    38.16(a)1
      IV(10790855-10794593)3
    1722981  NM_059366.41  NP_491767.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTR21 Ptr2p 45.46(n)
    29.21(a)
      853968   NP_013019.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PTR11 peptide transporter PTR1 47.67(n)
    36.25(a)
      824581  NM_115274.2  NP_190982.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01428001 hypothetical protein 45.95(n)
    33.18(a)
      4325456  NM_001048529.1  NP_001041994.1 


    ENSEMBL Gene Tree for SLC15A2 (if available)
    TreeFam Gene Tree for SLC15A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC15A2 gene
    SLC15A12  SLC15A52  SLC15A32  SLC15A42  
    3 SIMAP similar genes for SLC15A2 using alignment to 4 protein entries:     S15A2_HUMAN (see all proteins):
    hPEPT1-RF    SLC15A1    PEPT1

    SLC15A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1071 SNPs in SLC15A2 are shown (see all 1071)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509488621,2
    --121611221(+) GCTGGA/GCTCTT 2 -- us2k10--------
    rs1407889901,2
    C--121611399(+) GAGTTA/GTAGGT 2 -- us2k10--------
    rs1861658341,2
    --121611408(+) GTTTTC/TTCTCT 2 -- us2k10--------
    rs2010114061,2
    --121611410(+) TTCTC-/AAATCTTG 2 -- cds10--------
    rs782352821,2
    C--121611500(+) CTCTCC/TAGCCT 2 -- us2k10--------
    rs1385929861,2
    --121611545(+) GGGCAA/CCATGC 2 -- us2k10--------
    rs1907849461,2
    --121611611(+) CACCTA/GGCATT 2 -- us2k10--------
    rs98776711,2
    C,H--121611619(+) ATTATC/GATGTT 2 -- us2k112Minor allele frequency- G:0.08NA WA CSA EA 374
    rs1141431531,2
    F--121611627(+) GTTTGT/CTCTTG 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1413768341,2
    --121611780(+) ATGAAA/TATATA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC15A2 (121612936 - 121663034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC15A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877383CNV Loss21882294
    esv33139CNV Loss17666407
    nsv877384CNV Gain21882294
    nsv516233CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602339    OMIM disorders: --

    5 diseases for SLC15A2:    About MalaCards
    fibrosarcoma    hyperparathyroidism    cytochrome p450    cystic fibrosis
    multiple sclerosis


    SLC15A2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC15A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung tumor 24.1 1 14969997 (1)

    Genetic Association Database (GAD): SLC15A2
    Human Genome Epidemiology (HuGE) Navigator: SLC15A2 (8 documents)

    Export disorders for SLC15A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC15A2 gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with SLC15A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. (PubMed id 7756356)1, 2, 3, 7 Liu W.... Leibach F.H. (1995)
    2. Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. (PubMed id 18766334)1, 4, 9 Liu R....Lee E.J. (2009)
    3. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PubMed id 18713951)1, 7, 9 Knutter I....Brandsch M. (2008)
    4. Polymorphisms of delta-aminolevulinic acid dehydratas e (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lea d exposure. (PubMed id 19723536)1, 4, 9 Sobin C....Alterio H. (2009)
    5. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (2011)
    6. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    7. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (2009)
    8. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6565 HGNC: 10921 AceView: SLC15A2 Ensembl:ENSG00000163406 euGenes: HUgn6565
    ECgene: SLC15A2 H-InvDB: SLC15A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC15A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC15A2 gene:
    Search GeneIP for patents involving SLC15A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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