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Aliases for SLC15A2 Gene

Aliases for SLC15A2 Gene

  • Solute Carrier Family 15 Member 2 2 3 5
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 2 2 3
  • Solute Carrier Family 15 (H+/Peptide Transporter), Member 2 2 3
  • Oligopeptide Transporter, Kidney Isoform 3 4
  • Kidney H(+)/Peptide Cotransporter 3 4
  • Peptide Transporter 2 3 4
  • PEPT2 3 4

External Ids for SLC15A2 Gene

Previous GeneCards Identifiers for SLC15A2 Gene

  • GC03P118308
  • GC03P121254
  • GC03P122894
  • GC03P122934
  • GC03P123096
  • GC03P121612
  • GC03P118987

Summaries for SLC15A2 Gene

Entrez Gene Summary for SLC15A2 Gene

  • The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC15A2 Gene

SLC15A2 (Solute Carrier Family 15 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and peptide:proton symporter activity. An important paralog of this gene is SLC15A1.

UniProtKB/Swiss-Prot for SLC15A2 Gene

  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

Gene Wiki entry for SLC15A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A2 Gene

Genomics for SLC15A2 Gene

Regulatory Elements for SLC15A2 Gene

Enhancers for SLC15A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F121913 0.4 Ensembl 30.3 +20.0 20012 1.0 SLC15A2 IQCB1 GC03P121966
GH03F121973 0.6 ENCODE 18.6 +80.9 80917 3.1 CTCF PKNOX1 RAD21 GATA3 FOSL2 FOS ZBTB33 NFE2 SLC15A2 IQCB1 GC03P121966 LOC101927010
GH03F121919 0.5 FANTOM5 18.2 +25.2 25212 0.2 ZBTB11 IKZF1 NFE2 GABPA SLC15A2 CSTA ILDR1 GC03P121966
GH03F121994 1.2 FANTOM5 Ensembl ENCODE 17.8 +102.8 102825 5.8 CTCF TFAP4 JUN TEAD4 BMI1 ZNF384 EBF1 RAD21 RELA ZNF316 IQCB1 SLC15A2 CD86 EAF2 ENSG00000202388 ILDR1 CSTA HCLS1 LOC101927010
GH03F122002 1.2 FANTOM5 Ensembl ENCODE 14.7 +110.1 110076 3.1 BMI1 EBF1 RELA ZNF316 POLR2A EGR1 CBX5 EED ZNF207 CREM IQCB1 SLC15A2 CD86 ENSG00000202388 ILDR1 CSTA HCLS1 EAF2 LOC101927010
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC15A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC15A2 Gene

Chromosome:
3
Start:
121,894,089 bp from pter
End:
121,944,187 bp from pter
Size:
50,099 bases
Orientation:
Plus strand

Genomic View for SLC15A2 Gene

Genes around SLC15A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A2 Gene

Proteins for SLC15A2 Gene

  • Protein details for SLC15A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16348-S15A2_HUMAN
    Recommended name:
    Solute carrier family 15 member 2
    Protein Accession:
    Q16348
    Secondary Accessions:
    • A8K1A5
    • B4E2A7

    Protein attributes for SLC15A2 Gene

    Size:
    729 amino acids
    Molecular mass:
    81783 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC15A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC15A2 Gene

Post-translational modifications for SLC15A2 Gene

  • Glycosylation at Asn 7, Asn 269, Asn 373, Asn 435, Asn 472, Asn 528, and Asn 567
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A2 Gene

No data available for DME Specific Peptides for SLC15A2 Gene

Domains & Families for SLC15A2 Gene

Gene Families for SLC15A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16348

UniProtKB/Swiss-Prot:

S15A2_HUMAN :
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A2: view

Function for SLC15A2 Gene

Molecular function for SLC15A2 Gene

UniProtKB/Swiss-Prot Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

Gene Ontology (GO) - Molecular Function for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16738539
GO:0015198 oligopeptide transporter activity IEA --
GO:0015293 symporter activity IEA --
GO:0015333 peptide:proton symporter activity TAS --
genes like me logo Genes that share ontologies with SLC15A2: view
genes like me logo Genes that share phenotypes with SLC15A2: view

Animal Models for SLC15A2 Gene

MGI Knock Outs for SLC15A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC15A2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC15A2 Gene

Localization for SLC15A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC15A2 Gene COMPARTMENTS Subcellular localization image for SLC15A2 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7756356
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC15A2: view

Pathways & Interactions for SLC15A2 Gene

genes like me logo Genes that share pathways with SLC15A2: view

Interacting Proteins for SLC15A2 Gene

Gene Ontology (GO) - Biological Process for SLC15A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 7756356
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport IEA --
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
genes like me logo Genes that share ontologies with SLC15A2: view

No data available for SIGNOR curated interactions for SLC15A2 Gene

Drugs & Compounds for SLC15A2 Gene

(52) Drugs for SLC15A2 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amoxicillin Approved, Vet_approved Pharma Transporter, inhibitor 441
Ampicillin Approved, Vet_approved Pharma Target, Transporter, inhibitor 55
Azidocillin Approved Pharma Transporter, inhibitor 0
Benazepril Approved, Investigational Pharma Transporter, substrate 45
Cefaclor Approved Pharma Transporter, inhibitor 5

(6) Additional Compounds for SLC15A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxychlorpropamide
36892-36-1
Carnosine
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
305-84-0
genes like me logo Genes that share compounds with SLC15A2: view

Transcripts for SLC15A2 Gene

Unigene Clusters for SLC15A2 Gene

Solute carrier family 15 (H+/peptide transporter), member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A2 Gene

No ASD Table

Relevant External Links for SLC15A2 Gene

GeneLoc Exon Structure for
SLC15A2
ECgene alternative splicing isoforms for
SLC15A2

Expression for SLC15A2 Gene

mRNA expression in normal human tissues for SLC15A2 Gene

Protein differential expression in normal tissues from HIPED for SLC15A2 Gene

This gene is overexpressed in Nasal epithelium (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC15A2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC15A2 Gene:

SLC15A2

SOURCE GeneReport for Unigene cluster for SLC15A2 Gene:

Hs.518089
genes like me logo Genes that share expression patterns with SLC15A2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC15A2 Gene

Orthologs for SLC15A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A2 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia SLC15A2 34 35
  • 90.53 (n)
cow
(Bos Taurus)
Mammalia SLC15A2 35
  • 87 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc15a2 34 16 35
  • 85.23 (n)
rat
(Rattus norvegicus)
Mammalia Slc15a2 34
  • 85.14 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC15A2 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC15A2 34 35
  • 64.92 (n)
lizard
(Anolis carolinensis)
Reptilia SLC15A2 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a2 34
  • 61.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia slc15a2-prov 34
zebrafish
(Danio rerio)
Actinopterygii slc15a2 34 35
  • 61.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012154 34
  • 49.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH06717 36
  • 42 (a)
yin 36 35
  • 40 (a)
CG2930 35
  • 35 (a)
ManyToMany
CG9444 36
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea pept-3 34 35
  • 48.75 (n)
opt-1 36
  • 42 (a)
opt-2 36
  • 41 (a)
pept-2 35
  • 31 (a)
ManyToMany
pept-1 35
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 35
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0235700 34
  • 46.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for SLC15A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC15A2 Gene

ENSEMBL:
Gene Tree for SLC15A2 (if available)
TreeFam:
Gene Tree for SLC15A2 (if available)

Paralogs for SLC15A2 Gene

Paralogs for SLC15A2 Gene

(3) SIMAP similar genes for SLC15A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC15A2: view

Variants for SLC15A2 Gene

Sequence variations from dbSNP and Humsavar for SLC15A2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10470412 -- 121,894,207(+) ATAGA(C/T)TTTCT upstream-variant-2KB
rs10934562 -- 121,917,702(+) taaat(A/G)aataa intron-variant
rs111513693 -- 121,927,665(+) AACAG(C/T)CTAAT intron-variant
rs111647767 -- 121,900,992(+) AATAT(A/G)TATAA intron-variant
rs111774418 -- 121,930,693(+) ACAAT(A/G)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A2 Gene

Variant ID Type Subtype PubMed ID
esv33139 CNV loss 17666407
nsv516233 CNV gain+loss 19592680

Variation tolerance for SLC15A2 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.04; 98.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC15A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC15A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A2 Gene

Disorders for SLC15A2 Gene

Relevant External Links for SLC15A2

Genetic Association Database (GAD)
SLC15A2
Human Genome Epidemiology (HuGE) Navigator
SLC15A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC15A2

No disorders were found for SLC15A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC15A2 Gene

Publications for SLC15A2 Gene

  1. Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. (PMID: 7756356) Liu W. … Leibach F.H. (Biochim. Biophys. Acta 1995) 2 3 4 25 64
  2. Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. (PMID: 18766334) Liu R. … Lee E.J. (Eur. J. Clin. Pharmacol. 2009) 3 22 46 64
  3. Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure. (PMID: 19723536) Sobin C. … Alterio H. (Neurotoxicology 2009) 3 22 46 64
  4. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PMID: 18713951) KnA1tter I. … Brandsch M. (J. Pharmacol. Exp. Ther. 2008) 3 22 25 64
  5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64

Products for SLC15A2 Gene

Sources for SLC15A2 Gene

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