SLC15A1 Gene
protein-coding GIFtS: 57
GCID: GC13M099336
|
|
solute carrier family 15 (oligopeptide transporter), member...
| |
Aliases
for SLC15A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 15 (Oligopeptide Transporter), Member 11 2 | | Caco-2 Oligopeptide Transporter2 | | PEPT11 2 3 | | Intestinal H+/Peptide Cotransporter2 | | HPECT11 2 5 | | Macrophage Oligopeptide Transporter PEPT12 | | HPEPT11 2 | | Solute Carrier Family 15 Member 12 | | Oligopeptide Transporter, Small Intestine Isoform2 3 | | Intestinal H(+)/Peptide Cotransporter3 | | Peptide Transporter 12 3 | | |
Export aliases for SLC15A1 gene to outside databasesPrevious GC identifers: GC13M097696 GC13M093724 GC13M098172 GC13M097034 GC13M098134 GC13M079930 |
Summaries
for SLC15A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC15A1:
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. Theencoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di-and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestionof dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. (provided byRefSeq, Apr 2010)
UniProtKB/Swiss-Prot: S15A1_HUMAN, P46059Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitutea major route for the absorption of protein digestion end-products
Gene Wiki entry for SLC15A1 (Peptide transporter 1)
|
Genomic Views
for SLC15A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_009952.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC15A1 gene promoter:
SRF GR C/EBPbeta FOXF2 SRF (504 AA) GATA-1 Evi-1 GATA-6 FOXO4 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC15A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC15A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q32.3 Ensembl cytogenetic band: 13q32.3 HGNC cytogenetic band: 13q32.3SLC15A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M099336: view genomic region
(about GC identifiers)
Start:
|
99,336,055 bp from pter |
End:
|
99,404,929 bp from pter |
Size:
|
68,875 bases |
Orientation:
|
minus strand |
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Proteins
for SLC15A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S15A1_HUMAN, P46059 (See
protein sequence)Recommended Name: Solute carrier family 15 member 1 Size: 708 amino acids; 78806 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5VW82Explore the universe of human proteins at neXtProt for SLC15A1: NX_P46059
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P46059
SLC15A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005064.1
ENSEMBL proteins: ENSP00000365686 ENSP00000365677 Reactome Protein details: P46059
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SLC15A1 for ontologies About GeneDecksing
SLC15A1 Antibody Products:
Assay Products for SLC15A1: |
Protein
Domains /
Families
for SLC15A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC15A1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P46059ProtoNet protein and cluster: P46059 1 Blocks protein family: IPB000109 TGF-beta receptor
UniProtKB/Swiss-Prot: S15A1_HUMAN, P46059Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family |
Function
for SLC15A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S15A1_HUMAN, P46059Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitutea major route for the absorption of protein digestion end-products Genatlas biochemistry entry for SLC15A1:solute carrier family 15 (oligopeptide transport),member 1,expressed in small intestine
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC15A1 (NM_005073) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC15A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC15A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
-- | -- | | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity |
IEA | -- | | GO:0015333 | peptide:hydrogen symporter activity |
TAS | 7896779 |
SLC15A1 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Slc15a1):
SLC15A1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC15A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Amino acid and oligopeptide SLC transporters | | | 2 | SLC-mediated transmembrane transport | | | 3 | Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics | | | 4 | Proton/oligonucleotide cotransporters | | | 5 | Protein digestion and absorption | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for SLC15A1
2  PharmGKB Pathways for SLC15A1
1 
Kegg Pathway (Kegg details for SLC15A1):
SLC15A1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC15A1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for SLC15A1 (P460593 ENSP000003656864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
SLC15A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC15A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLC15A1 for compounds About GeneDecksing
 Browse Tocris compounds for SLC15A1
10/46 DrugBank Compounds for SLC15A1 (see all 46) About this table
10/52 Novoseek chemical compound relationships for SLC15A1 gene (see all 52) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glycylsarcosine |
97.7 |
70 |
16283203 (3), 16415530 (3), 19084598 (2), 10362647 (2) (see all 28) |
| tripeptide s |
91 |
29 |
16489544 (4), 16713701 (3), 15981923 (1), 17407174 (1) (see all 21) |
| cephalexin |
86.1 |
41 |
11602669 (5), 17142565 (5), 12679938 (2), 16394517 (2) (see all 15) |
| tripeptide |
84.1 |
27 |
12526824 (2), 11984519 (1), 16713701 (1), 19557803 (1) (see all 23) |
| cefadroxil |
83.1 |
7 |
18824524 (1), 8627565 (1), 16627568 (1), 18367661 (1) |
| cephradine |
82 |
5 |
14567632 (1), 12907294 (1), 8843163 (1), 15176063 (1) |
| valacyclovir |
81.3 |
23 |
11180195 (4), 10087037 (3), 15901802 (3), 12821497 (3) (see all 9) |
| glycylglutamine |
79.2 |
9 |
10199812 (2), 9686684 (1) |
| cyclacillin |
78.3 |
1 |
9950279 (1) |
| ceftibuten |
75.5 |
5 |
8843163 (2), 14567632 (1), 12415572 (1), 9950279 (1) |
Search CenterWatch for drugs/clinical trials and news about SLC15A1 / S15A1
|
Transcripts
for SLC15A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC15A1 gene: NM_005073.3 Unigene Cluster for SLC15A1: Solute carrier family 15 (oligopeptide transporter), member 1 Hs.436893 [show with all ESTs]Unigene Representative Sequence: NM_0050732 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376503(uc001vno.3) ENST00000376494(uc001vnp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC15A1 (NM_005073) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC15A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC15A1 |
Additional cDNA sequence: AB001328.1 AF043233.1 AY634368.1 BC096327.1 BC096328.3 BC096329.3 BC099651.1 EU544224.1 U13173.1 U21936.1 2 DOTS entries: DT.408579 DT.95332751 13 AceView cDNA sequences: BX280333 U13173 AW449979 BM756116 U21936 AB001328 AL708816 NM_005073 AA377392 AF043233 AY634368 AI167784 AI536543
GeneLoc Exon Structure
|
Expression
for SLC15A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC15A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAACCAGGA
About this image
See SLC15A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC15A1
SOURCE GeneReport for Unigene cluster: Hs.436893
SABiosciences Expression via Pathway-Focused PCR Array including SLC15A1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC15A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC15A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC15A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC15A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A1 |
Orthologs
for SLC15A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC15A1 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SLC15A11 |
solute carrier family 15 (oligopeptide transporter), more |
67.65(n)
66.42(a) |
|
378789 NM_204365.1 NP_989696.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SLC15A16 |
-- |
64(a) |
1 ↔ 1 |
3(98502512-98538118) |
zebrafish
(Danio rerio) |
Actinopterygii |
slc15a12 |
solute carrier family 15 (oligopeptide transporter), more |
76.9(n) |
|
325936 AY300011.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
BcDNA:GH067173
CG29301 |
proton-dependent oligopeptide transporter3
CG29301 |
40(a)
(best of 2)3
51.97(n)1
43.3(a)1 |
|
3F43
313411 NM_176683.21 NP_788856.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
opt-23
pept-21 |
Oligopeptide transporter3
Protein PEPT-21 |
44(a)
(best of 2)3
50.12(n)1
44.44(a)1 |
|
X(6492298-6496906)3
1779731 NM_069601.21 NP_502002.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PTR21 |
peptide transporter PTR2 |
46.31(n)
34.97(a) |
|
814735 NM_126265.3 NP_178313.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g07199001 |
hypothetical protein |
48.32(n)
35.1(a) |
|
4333931 NM_001057633.1 NP_001051098.1 |
ENSEMBL Gene Tree for SLC15A1 (if available)
TreeFam Gene Tree for SLC15A1 (if available) |
Paralogs
for SLC15A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC15A1 gene
- SLC15A22 SLC15A52 SLC15A32 SLC15A42
3 SIMAP similar genes for SLC15A1 using alignment to 3 protein entries: S15A1_HUMAN (see all proteins):PEPT1 hPEPT1-RF SLC15A2
SLC15A1 for paralogs About GeneDecksing
|
Genomic Variants
for SLC15A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC15A1 (99336055 - 99404929 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC15A1: --
Human Gene Mutation Database (HGMD): SLC15A1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC15A1 |
|
Disorders
/ Diseases
for SLC15A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC15A1 for disorders About GeneDecksing
OMIM gene information: 600544
OMIM disorders: --
15  diseases for SLC15A1: About MalaCardsinflammatory bowel disease short bowel syndrome cryptosporidiosis anoxia
colon carcinoma obesity, association with obesity pancreatic carcinoma
gastric cancer pharyngitis carcinoma pancreatitis
thyroiditis neuronitis alcoholism
8 Novoseek disease relationships for SLC15A1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammatory bowel diseases |
30.2 |
4 |
16950402 (1), 19462432 (1), 11375948 (1), 18061177 (1) |
| colitis ulcerative |
13.8 |
3 |
14561585 (1), 16328452 (1), 11375948 (1) |
| inflammation |
8.99 |
24 |
16950402 (3), 16328452 (2), 19462432 (2), 18575574 (2) (see all 10) |
| tumors |
2.3 |
4 |
16328452 (2), 18344442 (1) |
| atrophy |
0 |
1 |
12806628 (1) |
| metaplasia |
0 |
3 |
16259962 (1), 16616718 (1) |
| colon carcinoma |
0 |
2 |
16328452 (2) |
| cancer |
0 |
8 |
18344442 (2), 19789362 (2), 15827340 (1), 18652477 (1) (see all 5) |
Human Genome Epidemiology (HuGE) Navigator: SLC15A1 (5 documents)
Export disorders for SLC15A1 gene to outside databases
|
Publications
for SLC15A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC15A1 gene, integrated from 9 sources (see all 251):
(articles sorted by number of sources associating them with SLC15A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. (PubMed id 7896779)1, 2, 3, 7 Liang R.... Leibach F.H. (1995)
- Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PubMed id 18713951)1, 7, 9 Knutter I....Brandsch M. (2008)
- Oseltamivir (tamiflu) is a substrate of peptide trans porter 1. (PubMed id 19439487)1, 7, 9 Ogihara T....Tamai I. (2009)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. (PubMed id 7592745)1, 7 Ganapathy M.E....Leibach F.H. (1995)
- Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. (PubMed id 16328452)1, 9 Vavricka S.R....Chang E.B. (2006)
- CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. (PubMed id 10052994)7, 9 Han H.K....Amidon G.L. (1999)
- Substrate upregulation of the human small intestinal peptide transporter, hPepT1. (PubMed id 9508831)1, 9 Walker D.... Hirst B.H. (1998)
- Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response. (PubMed id 19549526)1, 9 Nguyen H.T....Merlin D. (2009)
|
External Searches for SLC15A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC15A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC15A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC15A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC15A1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC15A1 gene:
Search GeneIP for patents involving SLC15A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SLC15A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC15A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC15A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC15A1 | | | OriGene Protein Over-expression Lysate for SLC15A1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC15A1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC15A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC15A1 | | OriGene Custom Protein Services for SLC15A1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC15A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC15A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC15A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC15A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC15A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC15A1 |
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| | | | Search Tocris compounds for SLC15A1 |
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 | | | SLC15A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC15A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC15A1 |
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