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SLC15A1 Gene

protein-coding   GIFtS: 62
GCID: GC13M099336

Solute Carrier Family 15 (Oligopeptide Transporter), Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 15 (Oligopeptide Transporter), Member 11 2     Solute Carrier Family 15 Oligopeptide Transporter Member 11
Oligopeptide Transporter, Small Intestine Isoform2 3     HPEPT12
Peptide Transporter 12 3     Caco-2 Oligopeptide Transporter2
PEPT12 3     Intestinal H+/Peptide Cotransporter2
HPECT12 5     Macrophage Oligopeptide Transporter PEPT12
BA551M18.1.1 (Solute Carrier Family 15 (Oligopeptide Transporter) Member
1)1
     Solute Carrier Family 15 Member 12
Peptide Transporter HPEPT11     Intestinal H(+)/Peptide Cotransporter3

External Ids:    HGNC: 109201   Entrez Gene: 65642   Ensembl: ENSG000000883867   OMIM: 6005445   UniProtKB: P460593   

Export aliases for SLC15A1 gene to outside databases

Previous GC identifers: GC13M097696 GC13M093724 GC13M098172 GC13M097034 GC13M098134 GC13M079930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC15A1 Gene:
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15.
The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the
uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the
uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic
drugs. (provided by RefSeq, Apr 2010)

GeneCards Summary for SLC15A1 Gene:
SLC15A1 (solute carrier family 15 (oligopeptide transporter), member 1) is a protein-coding gene. Diseases associated with SLC15A1 include cryptosporidiosis, and short bowel syndrome. GO annotations related to this gene include peptide:hydrogen symporter activity and proton-dependent oligopeptide secondary active transmembrane transporter activity. An important paralog of this gene is SLC15A2.

UniProtKB/Swiss-Prot: S15A1_HUMAN, P46059
Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May
constitute a major route for the absorption of protein digestion end-products

Gene Wiki entry for SLC15A1 (Peptide transporter 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC15A1 gene promoter:
         SRF   GR   C/EBPbeta   FOXF2   SRF (504 AA)   GATA-1   Evi-1   GATA-6   FOXO4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC15A1 promoter sequence
   Search Chromatin IP Primers for SLC15A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC15A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.3

SLC15A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC15A1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M099336:  view genomic region     (about GC identifiers)

Start:
99,336,055 bp from pter      End:
99,404,929 bp from pter
Size:
68,875 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S15A1_HUMAN, P46059 (See protein sequence)
Recommended Name: Solute carrier family 15 member 1  
Size: 708 amino acids; 78806 Da
Secondary accessions: Q5VW82

Explore the universe of human proteins at neXtProt for SLC15A1: NX_P46059

Explore proteomics data for SLC15A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn50, Asn404, Asn408, Asn439, Asn509, Asn514, Asn562
  • Modification sites at PhosphoSitePlus

  • See SLC15A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005064.1  
    ENSEMBL proteins: 
     ENSP00000365686  
    Reactome Protein details: P46059

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Peptide transporter 1
    SLC15 family of peptide transporters

    4 InterPro protein domains:
     IPR000109 POT_fam
     IPR018456 PTR2_symporter_CS
     IPR004768 Oligopep_transport
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry P46059

    ProtoNet protein and cluster: P46059

    1 Blocks protein domain: IPB000109 TGF-beta receptor

    UniProtKB/Swiss-Prot: S15A1_HUMAN, P46059
    Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family


    SLC15A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S15A1_HUMAN, P46059
    Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May
    constitute a major route for the absorption of protein digestion end-products

         Genatlas biochemistry entry for SLC15A1:
    solute carrier family 15 (oligopeptide transport),member 1,expressed in small intestine

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005427proton-dependent oligopeptide secondary active transmembrane transporter activity IEA--
    GO:0015198oligopeptide transporter activity ----
    GO:0015333peptide:hydrogen symporter activity TAS7896779
         
    SLC15A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc15a1):
     digestive/alimentary 

    SLC15A1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC15A1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC15A1
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    miRNA
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    miRTarBase miRNAs that target SLC15A1:
    hsa-mir-92b-3p (MIRT004048)

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    hsa-miR-193a-3p hsa-miR-3653 hsa-miR-520a-5p hsa-miR-3922-3p hsa-miR-374c hsa-miR-3658 hsa-miR-525-5p hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidSLC15A1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S15A1_HUMAN, P46059: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7896779
    GO:0016020membrane TAS7896779
    GO:0016021integral component of membrane ----

    SLC15A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC15A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Proton/oligonucleotide cotransporters0.00
    2Statin Pathway - Generalized, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics0.50
    Fluvastatin Pathway, Pharmacokinetics0.00
    Ibuprofen Pathway, Pharmacokinetics0.50
    3Protein digestion and absorption
    Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC15A1
        Proton/oligonucleotide cotransporters

    3 PharmGKB Pathways for SLC15A1
        Fluvastatin Pathway, Pharmacokinetics
    Ibuprofen Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SLC15A1):
        Protein digestion and absorption


    SLC15A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC15A1: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC15A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SLC15A1 (P460593 ENSP000003656864) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR3P611583, ENSP000002632384I2D: score=1 STRING: ENSP00000263238
    PDZD3ENSP000003271074STRING: ENSP00000327107
    UBR3ENSP000003960684STRING: ENSP00000396068
    ABCG2ENSP000002376124STRING: ENSP00000237612
    UBR1ENSP000002906504STRING: ENSP00000290650
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7896779
    GO:0006811ion transport TAS--
    GO:0006857oligopeptide transport ----
    GO:0007586digestion TAS7896779
    GO:0015031protein transport IEA--

    SLC15A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC15A1 (S15A1)

    Selected DrugBank Compounds for SLC15A1 (see all 50)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CefadroxilCDX (see all 3)66592-87-8transportersubstrate inhibitor8627565 15618677 10087037 15567297 7592745 16627568 9753615 9374833 9379359
    CephalexinCefalessina [DCIT] (see all 12)15686-71-2transportersubstrate inhibitor8627565 10087037 15567297 7896779 7592745 10052994 9374833 8956326 9379359
    CefiximeCefixim (see all 4)79350-37-1transportersubstrate inhibitor8627565 15618677 15567297 9374833 9092716 9190878 9379359
    Ceftibuten-- 97519-39-6transportersubstrate inhibitor15618677 15567297 8531138 12415572 9374833 9092716 9190878
    ValaciclovirValaciclovir Hcl (see all 6)124832-27-5transportersubstrate inhibitor9706043 10525090 11180195 10087037 9753615 9610386
    AmoxicillinAmoxicilina [INN-Spanish] (see all 9)26787-78-0transporterinhibitor8627565 15567297 16434549 16627568 9374833
    AmpicillinAminobenzylpenicillin (see all 16)69-53-4transporterinhibitor10087037 15567297 16627568 9374833 8956326
    Bestatin-- --transporterinhibitor8531138 8639691 16627568 9190878 11007306
    Cefradine-- 38821-53-3transportersubstrate inhibitor9706043 8531138 10052994 9374833 9190878
    Azidocillin-- 17243-38-8transporterinhibitor10087037 15567297 9374833 8956326

    5 IUPHAR Ligands for SLC15A1 (Peptide transporter 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [14C]GlySar
    NoneNone--
    [3H]GlySar
    NoneNone--
    [11C]GlySar
    NoneNone--
    Lys[Z(NO2)]-Pro
    InhibitorInhibition11284702
    4-AMBA
    InhibitorInhibition15930458

    Selected Novoseek inferred chemical compound relationships for SLC15A1 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycylsarcosine 97.7 70 16283203 (3), 16415530 (3), 19084598 (2), 10362647 (2) (see all 28)
    tripeptide s 91 29 16489544 (4), 16713701 (3), 15981923 (1), 17407174 (1) (see all 21)
    cephalexin 86.1 41 11602669 (5), 17142565 (5), 12679938 (2), 16394517 (2) (see all 15)
    tripeptide 84.1 27 12526824 (2), 11984519 (1), 16713701 (1), 19557803 (1) (see all 23)
    cefadroxil 83.1 7 18824524 (1), 8627565 (1), 16627568 (1), 18367661 (1)
    cephradine 82 5 14567632 (1), 12907294 (1), 8843163 (1), 15176063 (1)
    valacyclovir 81.3 23 11180195 (4), 10087037 (3), 15901802 (3), 12821497 (3) (see all 9)
    glycylglutamine 79.2 9 10199812 (2), 9686684 (1)
    cyclacillin 78.3 1 9950279 (1)
    ceftibuten 75.5 5 8843163 (2), 14567632 (1), 12415572 (1), 9950279 (1)



    SLC15A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC15A1 gene: 
    NM_005073.3  

    Unigene Cluster for SLC15A1:

    Solute carrier family 15 (oligopeptide transporter), member 1
    Hs.436893  [show with all ESTs]
    Unigene Representative Sequence: NM_005073
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376503(uc001vno.3) ENST00000376494(uc001vnp.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC15A1

    Additional mRNA sequence: 

    AB001328.1 AF043233.1 AY634368.1 BC096327.1 BC096328.3 BC096329.3 BC099651.1 EU544224.1 
    U13173.1 U21936.1 

    2 DOTS entries:

    DT.408579  DT.95332751 

    13 AceView cDNA sequences:

    AW449979 BX280333 U13173 BM756116 AF043233 NM_005073 AB001328 AA377392 
    U21936 AL708816 AI167784 AY634368 AI536543 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC15A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACCAGGA
    SLC15A1 Expression
    About this image


    SLC15A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)
             Renal proximal tubularlike cells
     
     Epidermis (Integumentary System)
     
     Gall Bladder (Hepatobiliary System)
    SLC15A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC15A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436893
        Pathway & Disease-focused RT2 Profiler PCR Array including SLC15A1: 
              Drug Transporters in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC15A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC15A1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc15a11 , 5 solute carrier family 15 (oligopeptide transporter), more1, 5 83.24(n)1
    85.17(a)1
      14 (65.26 cM)5
    566431  NM_053079.21  NP_444309.21 
     1214596215 
    chicken
    (Gallus gallus)
    Aves SLC15A11 solute carrier family 15 (oligopeptide transporter), more 67.6(n)
    66.32(a)
      378789  NM_204365.1  NP_989696.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC15A16
    solute carrier family 15 (oligopeptide transporter...
    62(a)
    1 ↔ 1
    3(98501789-98541014)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc15a11 solute carrier family 15 (oligopeptide transporter), more 64.86(n)
    65.74(a)
      100145353  XM_002935646.2  XP_002935692.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slc15a12 solute carrier family 15 (oligopeptide transporter), more 76.9(n)   325936  AY300011.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH067173
    CG29301
    proton-dependent oligopeptide
    transporter3
    CG29301
    40(a)
    (best of 2)3
    52.14(n)1
    44.06(a)1
      3F43
    313411  NM_176684.21  NP_788857.11 
    worm
    (Caenorhabditis elegans)
    Secernentea opt-23
    pept-11
    Oligopeptide transporter3
    pept-11
    44(a)
    (best of 2)3
    54.74(n)1
    45.06(a)1
      X(6492298-6496906)3
    1809191  NM_076686.51  NP_509087.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTR21 PTR2 47.01(n)
    32.68(a)
      853968   NP_013019.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PTR21 PTR2 47.41(n)
    37.03(a)
      814735  NM_126265.3  NP_178313.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07199001 Os03g0719900 48.48(n)
    35.34(a)
      4333931  NM_001057633.1  NP_001051098.1 


    ENSEMBL Gene Tree for SLC15A1 (if available)
    TreeFam Gene Tree for SLC15A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC15A1 gene
    SLC15A22  SLC15A52  SLC15A32  SLC15A42  
    3 SIMAP similar genes for SLC15A1 using alignment to 3 protein entries:     S15A1_HUMAN (see all proteins):
    PEPT1    hPEPT1-RF    SLC15A2

    SLC15A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC15A1 (see all 1720)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463041641,2
    C,Funtested180284698(+) TGTCAC/G/TCATCT 2 M V mis11NA 4548
    rs1876582361,2
    --80261993(+) CACCCA/GCCTCT 1 -- ds50010--------
    rs1407677741,2
    --80262026(+) CAGGCA/GTGAGC 1 -- ds50010--------
    rs1381377451,2
    C--80262087(+) CTGTT-/TGTC  
            
    TGTCT
    1 -- ds50010--------
    rs1134632231,2
    C--80262092(+) TGTCTA/GTCTAT 1 -- ds50010--------
    rs1454752121,2
    C--80262165(+) CTATC-/ATCT  
            
    ATCTA
    1 -- ds50010--------
    rs1482145451,2
    --80262212(+) GCCTAC/TGTATC 1 -- ds50010--------
    rs46462351,2
    C,F,A,H--80262351(-) CTTAAG/ACCTAA 1 -- ds500124Minor allele frequency- A:0.20NS EA NA 2398
    rs12893891,2
    C,F,O,A,H--80262587(+) GTTTTC/TGTAAG 1 -- ut31 ese330Minor allele frequency- T:0.18EA NA NS WA 3025
    rs46462341,2
    C,F,A,H--80262677(-) TCCCTA/GTCACA 1 -- ut31 ese321Minor allele frequency- G:0.21NS EA NA WA 2482

    HapMap Linkage Disequilibrium report for SLC15A1 (99336055 - 99404929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC15A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747861CNV Deletion23290073
    nsv900946CNV Loss21882294
    nsv518082CNV Gain19592680

    Human Gene Mutation Database (HGMD): SLC15A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC15A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC15A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600544    OMIM disorders: --

    13 diseases for SLC15A1:    
    About MalaCards
    cryptosporidiosis    short bowel syndrome    anoxia    obesity, association with
    smallpox    inflammatory bowel disease    hyperparathyroidism    obesity
    thyroiditis    pancreatitis    prostate cancer    malaria
    prostatitis


    SLC15A1 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for SLC15A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory bowel diseases 30.2 4 16950402 (1), 19462432 (1), 11375948 (1), 18061177 (1)
    colitis ulcerative 13.8 3 14561585 (1), 16328452 (1), 11375948 (1)
    inflammation 8.99 24 16950402 (3), 16328452 (2), 19462432 (2), 18575574 (2) (see all 10)
    tumors 2.3 4 16328452 (2), 18344442 (1)
    atrophy 0 1 12806628 (1)
    metaplasia 0 3 16259962 (1), 16616718 (1)
    colon carcinoma 0 2 16328452 (2)
    cancer 0 8 18344442 (2), 19789362 (2), 15827340 (1), 18652477 (1) (see all 5)

    Genetic Association Database (GAD): SLC15A1
    Human Genome Epidemiology (HuGE) Navigator: SLC15A1 (5 documents)

    Export disorders for SLC15A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC15A1 gene, integrated from 10 sources (see all 259):
    (articles sorted by number of sources associating them with SLC15A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. (PubMed id 7896779)1, 2, 3, 7 Liang R.... Leibach F.H. (J. Biol. Chem. 1995)
    2. PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. (PubMed id 19462432)1, 4, 9 Zucchelli M....D'Amato M. (Inflamm. Bowel Dis. 2009)
    3. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PubMed id 18713951)1, 7, 9 KnA1tter I....Brandsch M. (J. Pharmacol. Exp. Ther. 2008)
    4. Oseltamivir (tamiflu) is a substrate of peptide transporter 1. (PubMed id 19439487)1, 7, 9 Ogihara T....Tamai I. (Drug Metab. Dispos. 2009)
    5. Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. (PubMed id 16627568)1, 7, 9 Sala-Rabanal M....Wright E.M. (J. Physiol. (Lond.) 2006)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    8. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6564 HGNC: 10920 AceView: SLC15A1 Ensembl:ENSG00000088386 euGenes: HUgn6564
    ECgene: SLC15A1 Kegg: 6564 H-InvDB: SLC15A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC15A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC15A1 gene:
    Search GeneIP for patents involving SLC15A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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