Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC14A2 Gene

protein-coding   GIFtS: 56
GCID: GC18P042792

Solute Carrier Family 14 (Urea Transporter), Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 14 (Urea Transporter), Member 21 2     UT-A22
UT22 3 5     UTA2
Solute Carrier Family 14 Member 22 3     hUT-A62
Urea Transporter, Kidney2 3     Urea Transporter 22
HUT22 3     Urea Transporter-22
UTR2 5     

External Ids:    HGNC: 109191   Entrez Gene: 81702   Ensembl: ENSG000001328747   OMIM: 6016115   UniProtKB: Q158493   

Export aliases for SLC14A2 gene to outside databases

Previous GC identifers: GC18P043517 GC18P042991 GC18P041456 GC18P041446 GC18P041448 GC18P043194 GC18P040052 GC18P042747


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC14A2 Gene:
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end
product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein
is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the
inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Sep 2011)

GeneCards Summary for SLC14A2 Gene:
SLC14A2 (solute carrier family 14 (urea transporter), member 2) is a protein-coding gene. Diseases associated with SLC14A2 include alopecia. GO annotations related to this gene include urea transmembrane transporter activity. An important paralog of this gene is SLC14A1.

UniProtKB/Swiss-Prot: UT2_HUMAN, Q15849
Function: Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea
transport across the inner medullary collecting duct and plays a major role in the urinary concentrating
mechanism

Gene Wiki entry for SLC14A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC14A2 gene promoter:
         Max1   MEF-2   Pax-2   Pax-2a   XBP-1   MEF-2A   HFH-1   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC14A2 promoter sequence
   Search Chromatin IP Primers for SLC14A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC14A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1-q21.1   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q12.1-q21.1

SLC14A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC14A2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P042792:  view genomic region     (about GC identifiers)

Start:
42,792,947 bp from pter      End:
43,263,072 bp from pter
Size:
470,126 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UT2_HUMAN, Q15849 (See protein sequence)
Recommended Name: Urea transporter 2  
Size: 920 amino acids; 101209 Da
Subunit: Isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane
Secondary accessions: A8K8Q7 Q2TBD6 Q96PH5
Alternative splicing: 2 isoforms:  Q15849-1   Q15849-2   

Explore the universe of human proteins at neXtProt for SLC14A2: NX_Q15849

Explore proteomics data for SLC14A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn733
  • Modification sites at PhosphoSitePlus

  • See SLC14A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229621.1  NP_009094.3  

    ENSEMBL proteins: 
     ENSP00000465953   ENSP00000255226   ENSP00000320689   ENSP00000465349  
    Reactome Protein details: Q15849

    SLC14A2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC14A2
    GenScript Custom Purified and Recombinant Proteins Services for SLC14A2
    Novus Biologicals SLC14A2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC14A2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC14A2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC14A2
    Novus Biologicals SLC14A2 Antibodies
    Abcam antibodies for SLC14A2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC14A2
    LSBio Antibodies in human, mouse, rat for SLC14A2

    SLC14A2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC14A2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC14A2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kidney urea transporter
    SLC14 family of facilitative urea transporters

    1 InterPro protein domain:
     IPR004937 Urea_transporter

    Graphical View of Domain Structure for InterPro Entry Q15849

    ProtoNet protein and cluster: Q15849

    1 Blocks protein domain: IPB004937 Urea transporter

    UniProtKB/Swiss-Prot: UT2_HUMAN, Q15849
    Similarity: Belongs to the urea transporter family


    SLC14A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UT2_HUMAN, Q15849
    Function: Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea
    transport across the inner medullary collecting duct and plays a major role in the urinary concentrating
    mechanism
    Induction: Isoform 1 is induced by low protein in the diet. Isoform 2 is induced by dehydration

         Genatlas biochemistry entry for SLC14A2:
    solute carrier family (urea transport),member 2,expressed in kidney

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17702749
    GO:0015204urea transmembrane transporter activity IEA--
         
    SLC14A2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Slc14a2):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     no phenotypic analysis  renal/urinary system  reproductive system 

    SLC14A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC14A2: Slc14a2tm1Suc Slc14a2tm1Raf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC14A2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC14A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC14A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC14A2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SLC14A2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SLC14A2:
    hsa-miR-920 hsa-miR-142-5p hsa-miR-4300 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSLC14A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC14A2
    Predesigned siRNA for gene silencing in human, mouse, rat SLC14A2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC14A2

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC14A2 (see all 10)
    OriGene ORF clones in mouse, rat for SLC14A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC14A2 (NM_007163)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC14A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC14A2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC14A2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC14A2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC14A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UT2_HUMAN, Q15849: Apical cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS8647271
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IEA--

    SLC14A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC14A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC14A2
        Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds



    SLC14A2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC14A2: 
              Diabetes in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC14A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC14A2 (Q158491 ENSP000002552264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNAPINO952951, ENSP000003576744EBI-1633392,EBI-296723 STRING: ENSP00000357674
    MDM2ENSP000004172814STRING: ENSP00000417281
    UBCENSP000003448184STRING: ENSP00000344818
    UBBENSP000003046974STRING: ENSP00000304697
    MDM4ENSP000003561504STRING: ENSP00000356150
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015840urea transport TAS8647271
    GO:0055085transmembrane transport TAS--
    GO:0071918urea transmembrane transport ----

    SLC14A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC14A2 (UT2)

    1 HMDB Compound for SLC14A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    UreaCarbonyl diamine (see all 90)57-13-6--

    1 Novoseek inferred chemical compound relationship for SLC14A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urea 76.1 24 9019665 (3), 15189812 (3), 8997401 (2), 20457831 (2) (see all 10)

    1 PharmGKB related drug/compound annotation for SLC14A2 gene    About this table
    Drug/compound PharmGKB Annotation
    nifedipineCA  



    SLC14A2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC14A2 gene (2 alternative transcripts): 
    NM_001242692.1  NM_007163.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586448 ENST00000255226(uc010dnj.3 uc002lbe.3) ENST00000323329(uc002lbb.3)
    ENST00000589658
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC14A2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SLC14A2:
    hsa-miR-920 hsa-miR-142-5p hsa-miR-4300 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSLC14A2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC14A2
    Predesigned siRNA for gene silencing in human, mouse, rat SLC14A2
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC14A2 (see all 10)
    OriGene ORF clones in mouse, rat for SLC14A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC14A2 (NM_007163)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC14A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC14A2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC14A2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC14A2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC14A2
      QuantiTect SYBR Green Assays in human, mouse, rat SLC14A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC14A2

    7 AceView cDNA sequences:

    NM_007163 AK074236 AI002801 AF349446 AW452158 BI021932 X96969 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC14A2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -                                             
    SP2:                          -                                                   
    SP3:                                                                              


    ECgene alternative splicing isoforms for SLC14A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC14A2 expression in normal human tissues (normalized intensities)      SLC14A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC14A2 Expression
    About this image


    SLC14A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
     
     Kidney (Urinary System)
    SLC14A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC14A2 Protein Expression

    UniProtKB/Swiss-Prot: UT2_HUMAN, Q15849
    Tissue specificity: Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC14A2: 
              Diabetes in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC14A2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC14A2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC14A2
    QuantiTect SYBR Green Assays in human, mouse, rat SLC14A2
    QuantiFast Probe-based Assays in human, mouse, rat SLC14A2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC14A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC14A2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc14a21 , 5 solute carrier family 14 (urea transporter), member more1, 5 85.33(n)1
    85.43(a)1
      18 (52.53 cM)5
    274111  NM_207651.31  NP_997534.21 
     781469405 
    chicken
    (Gallus gallus)
    Aves SLC14A21 solute carrier family 14 (urea transporter), member more 66(n)
    65.05(a)
      770445  XM_003642906.2  XP_003642954.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe01a062 Transcribed sequence with weak similarity to protein more 72.26(n)    57059757 


    ENSEMBL Gene Tree for SLC14A2 (if available)
    TreeFam Gene Tree for SLC14A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC14A2 gene
    SLC14A12  
    5 SIMAP similar genes for SLC14A2 using alignment to 3 protein entries:     UT2_HUMAN (see all proteins):
    JK    HUT11    SLC14A1    UT-B1    SLC14A1 JK

    SLC14A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC14A2 (see all 9958)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359153651,2
    C--39965739(+) GGGGG-/GG/G  
     GG
    /GGGG
    TGTCT
    2 -- int1 cds11NA 2
    rs1916297761,2
    --42790956(+) TTGCTA/GAGTGA 1 -- us2k10--------
    rs1507864441,2
    --42791004(+) TTTTCA/CCCTTT 1 -- us2k10--------
    rs1392065281,2
    --42791102(+) AGAAGA/GAGCTA 1 -- us2k10--------
    rs4168081,2
    C,F,A,H--42791236(-) AAAGGC/TAAACA 1 -- us2k123Minor allele frequency- T:0.19NS EA NA WA CSA 2351
    rs1834140481,2
    --42791320(+) ACTAAC/TCAATC 1 -- us2k10--------
    rs1873114491,2
    --42791384(+) CAGTGC/TGCAAG 1 -- us2k10--------
    rs3761421,2
    C,F,A,H--42791439(-) TCTCCG/CTAAAA 1 -- us2k117Minor allele frequency- C:0.17NS EA NA WA CSA 791
    rs797068801,2
    C,F--42791603(+) CTCCTT/CCTTTA 1 -- us2k12Minor allele frequency- C:0.08WA NA 238
    rs1917152101,2
    --42791646(+) TCAGCA/CCTTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC14A2 (42792947 - 43042947 bp, first 250kb of SLC14A2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC14A2 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717023CNV Deletion23290073
    esv2593617CNV Deletion19546169
    esv2073991CNV Deletion18987734
    esv2393030CNV Deletion18987734
    esv991584CNV Deletion20482838
    esv3150CNV Deletion18987735
    esv2660868CNV Deletion23128226
    esv2717024CNV Deletion23290073
    esv2661309CNV Deletion23128226
    esv2457646CNV Deletion19546169

    Human Gene Mutation Database (HGMD): SLC14A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC14A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC14A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601611    OMIM disorders: --

    1 disease for SLC14A2:    About MalaCards
    alopecia


    SLC14A2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC14A2
    Human Genome Epidemiology (HuGE) Navigator: SLC14A2 (5 documents)

    Export disorders for SLC14A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC14A2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SLC14A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a new urea transporter in the human kidney. (PubMed id 8647271)1, 2, 3 Olives B.... Bailly P. (FEBS Lett. 1996)
    2. Genetic variation in the human urea transporter-2 is associated with variation in blood pressure. (PubMed id 11590132)1, 4, 9 Ranade K....Botstein D. (Hum. Mol. Genet. 2001)
    3. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PubMed id 21909109)1, 4 Kim Y.J....Cho Y.S. (Nat. Genet. 2011)
    4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    7. Genetic variants of human urea transporter-2 are associated with metabolic syndrome in Asian population. (PubMed id 20797394)1, 4 Tsai H.J....Sheu W.H. ( international journal of clinical chemistry 2010)
    8. Genome-wide association study of biochemical traits in Korcula Island, Croatia. (PubMed id 19260141)1, 4 Zemunik T....Rudan I. (Croat. Med. J. 2009)
    9. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. (PubMed id 17702749)1, 2 Mistry A.C....Sands J.M. (J. Biol. Chem. 2007)
    10. Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS. (PubMed id 17344938)1, 4 Hong X....Xu X. (Methods Find Exp Clin Pharmacol 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8170 HGNC: 10919 AceView: SLC14A2 Ensembl:ENSG00000132874 euGenes: HUgn8170
    ECgene: SLC14A2 H-InvDB: SLC14A2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC14A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC14A2 gene:
    Search GeneIP for patents involving SLC14A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC14A2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for SLC14A2 (UT2/SLC14A2)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC14A2  
     OriGene qPCR primer pairs and template standards for SLC14A2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC14A2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC14A2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC14A2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC14A2   OriGene Custom Protein Services for SLC14A2  

     
     
     Block miRNA regulation of human, mouse, rat SLC14A2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC14A2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC14A2 Predesigned siRNA for gene silencing in human, mouse, rat SLC14A2
     QuantiFast Probe-based Assays in human, mouse, rat SLC14A2 QuantiTect SYBR Green Assays in human, mouse, rat SLC14A2
     PCR Arrays including human, mouse, rat SLC14A2 Search Chromatin IP Primers for SLC14A2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC14A2  GeneGlobe Interaction Network for SLC14A2
     Regulatory tfbs in SLC14A2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC14A2 GenScript cDNA clones with any tag delivered in your preferred vector for SLC14A2
     GenScript Custom Assay Services for SLC14A2 GenScript Custom overexpressing Cell Line Services for SLC14A2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC14A2 (UT2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC14A2 antibodies
     SLC14A2 proteins
     Antibodies for SLC14A2
     See all of Abcam's Antibodies, Kits and Proteins for SLC14A2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC14A2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC14A2
     SwitchGear 3'UTR luciferase reporter plasmids for SLC14A2
     SwitchGear Promoter luciferase reporter plasmids for SLC14A2
     Search ThermoFisher Antibodies for SLC14A2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC14A2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC14A2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC14A2
     LSBio Antibodies in human, mouse, rat for SLC14A2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC14A2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4