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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC14A1 Gene

protein-coding   GIFtS: 59
GCID: GC18P043304

solute carrier family 14 (urea transporter), member 1 (Kidd...


(Previous symbol: JK)
 Explore 4 diseases affiliated with
SLC14A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC14A1    

Aliases
for SLC14A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group)1 2     UTE2 3
JK1 2 3     UT-B12
RACH11 2 3     SLC14A1 JK2
HsT13411 2     Urea Transporter 12
RACH21 2     Urea Transporter JK Glycoprotein2
Urea Transporter, Erythrocyte2 3     Urea Transporter-B12
HUT112 3     Solute Carrier Family 14 Member 13
UT12 3     

External Ids:    HGNC: 109181   Entrez Gene: 65632   Ensembl: ENSG000001414697   OMIM: 6138685   UniProtKB: Q133363   

Export aliases for SLC14A1 gene to outside databases

Previous GC identifers: GC18P043616 GC18P043090 GC18P043193 GC18P041556 GC18P041558 GC18P040161


Summaries
for SLC14A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC14A1:
The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene
forms the basis for the Kidd blood group system. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336
Function: Specialized low-affinity urea transporter. Mediates urea transport in erythrocytes

Gene Wiki entry for SLC14A1


Genomic Views
for SLC14A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC14A1 gene promoter:
         Max1   SREBP-1c   Bach2   LUN-1   C/EBPalpha   RORalpha1   PPAR-gamma1   HOXA5   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC14A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC14A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC14A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11-q12   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q11-q12

SLC14A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC14A1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P043304:  view genomic region     (about GC identifiers)

Start:
 43,304,092 bp from pter      End:
 43,332,485 bp from pter
Size:
 28,394 bases      Orientation:
 plus strand

Proteins
for SLC14A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336 (See protein sequence)
Recommended Name: Urea transporter 1  
Size: 389 amino acids; 42528 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane (By similarity)
Secondary accessions: A8K0P3 B3KR62 B3KVX3 C9EHF2 Q86VM5
Alternative splicing: 2 isoforms:  Q13336-1   Q13336-2   

Explore the universe of human proteins at neXtProt for SLC14A1: NX_Q13336

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13336

    • SLC14A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001122060.3  NP_001139508.2  NP_001139509.1  NP_056949.4  

    ENSEMBL proteins: 
     ENSP00000318546   ENSP00000465029   ENSP00000442180   ENSP00000465702   ENSP00000412309  
     ENSP00000441998   ENSP00000385320   ENSP00000467898   ENSP00000466273   ENSP00000390637  
     ENSP00000466093   ENSP00000468763   ENSP00000465044   ENSP00000465150   ENSP00000465892  
    Reactome Protein details: Q13336
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC14A1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7989337
    GO:0016021integral to membrane ----


    SLC14A1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC14A1

    Protein Domains /
    Families
    for SLC14A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC14A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004937 Urea_transporter

    Graphical View of Domain Structure for InterPro Entry Q13336

    ProtoNet protein and cluster: Q13336

    1 Blocks protein family: IPB004937 Urea transporter


    Function
    for SLC14A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336
    Function: Specialized low-affinity urea transporter. Mediates urea transport in erythrocytes

         Genatlas biochemistry entry for SLC14A1:
    solute carrier family 14 (urea transport),member 1,36kDa,erythroid,same as Kidd (JK),see symbol

    miRNA
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    hsa-miR-21* hsa-miR-520e hsa-miR-302d hsa-miR-4254 hsa-miR-429 hsa-miR-200a hsa-miR-141 hsa-miR-374c
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005372water transmembrane transporter activity IEA--
    GO:0008519ammonium transmembrane transporter activity IEA--
    GO:0015204urea transmembrane transporter activity IEA--


    SLC14A1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slc14a1tm1Ask for SLC14A1
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc14a1):
     behavior/neurological  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  renal/urinary system  reproductive system 

    SLC14A1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC14A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Amine compound SLC transporters
    		Amine compound SLC transporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC14A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Amine compound SLC transporters



    SLC14A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC14A1

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006833water transport ----
    GO:0015840urea transport TAS7989337
    GO:0055085transmembrane transport TAS--
    GO:0071918urea transmembrane transport ----


    SLC14A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC14A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC14A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC14A1

    1 HMDB Compound for SLC14A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    UreaCarbonyl diamine (see all 90)57-13-6--
    2 Novoseek chemical compound relationships for SLC14A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urea 71.8 28 9582331 (4), 8542029 (2), 11841450 (2), 10514515 (2) (see all 11)
    vas-a 67.6 5 8995727 (3), 9582331 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC14A1 / UT1 

    Transcripts
    for SLC14A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC14A1 gene (4 alternative transcripts): 
    NM_001128588.3  NM_001146036.2  NM_001146037.1  NM_015865.6  

    Unigene Cluster for SLC14A1:

    Solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
    Hs.101307  [show with all ESTs]
    Unigene Representative Sequence: NM_001146037
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000321925(uc002lbi.4 uc002lbf.4 uc010xco.2 uc002lbk.4 uc021ujg.1)
    ENST00000587601 ENST00000502059 ENST00000586951 ENST00000415427(uc010dnk.3 uc010xcn.2 uc002lbg.4 uc002lbh.4)
    ENST00000535474 ENST00000402943 ENST00000588179 ENST00000589322 ENST00000586056
    ENST00000436407(uc002lbj.4) ENST00000589891 ENST00000590246 ENST00000591943
    ENST00000586142 ENST00000589700 ENST00000590377 ENST00000591642

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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC14A1 (see all 37):
    hsa-miR-21* hsa-miR-520e hsa-miR-302d hsa-miR-4254 hsa-miR-429 hsa-miR-200a hsa-miR-141 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: SLC14A1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SLC14A1
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    Clone
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    Additional cDNA sequence: 

    AF263545.1 AF328892.1 AK091064.1 AK289608.1 AK294129.1 AK295268.1 BC050539.1 GQ502682.1 
    HQ709264.1 L36121.1 U35735.1 Y19039.1 

    10 DOTS entries:

    DT.111587  DT.75101356  DT.101983510  DT.95108081  DT.101983511  DT.92421881  DT.95161079  DT.95161080 
    DT.95161081  DT.91824779 

    24/104 AceView cDNA sequences (see all 104):

    Y19039 AA857758 AI684202 AF328892 BF512246 CA428601 AK091064 N47509 
    AI431860 AI056236 AW472964 AX746761 R98010 T08809 CA453695 U35735 
    L36121 BU658809 NM_015865 AW069778 AW069779 BG292435 BV183818 BE673587 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SLC14A1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
    SP1:                          -           -     -     -     -     -     -                       -                                                     -         
    SP2:                          -           -                       -     -     -     -     -     -                                                     -         
    SP3:                                                              -     -                       -                                                     -         
    SP4:                          -           -     -     -     -     -     -     -     -     -     -                                                     -         
    SP5:                                                                                            -                                                     -         

    ExUns: 10c ^ 11 ^ 12a · 12b · 12c · 12d · 12e
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SLC14A1

    Expression
    for SLC14A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC14A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAATTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC14A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Floor PlateSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Adult human kidney epithelial cells (Primary Cell)Kidney

    See SLC14A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC14A1

    SOURCE GeneReport for Unigene cluster: Hs.101307

    UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336
    Tissue specificity: Erythrocytes

        SABiosciences Expression via Pathway-Focused PCR Array including SLC14A1: 
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    In Situ
    Assay Products:     
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    Orthologs
    for SLC14A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SLC14A1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc14a11 , 5 solute carrier family 14 (urea transporter), member more1, 5 83.41(n)1
    82.05(a)1    		   18 (52.49 cM)5
    1080521  NM_001171010.11  NP_001164481.11 
     781000915 
    chicken
    (Gallus gallus)    		 Aves SLC14A26
    		 Uncharacterized protein
    		 26(a)
    		 1 ↔ 1
    		 Z(2042241-2082253)
    lizard
    (Anolis carolinensis)    		 Reptilia SLC14A16
    		 --
    		 57(a)
    		 1 ↔ 1
    		 1(35270691-35294856)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc14a26
    		 solute carrier family 14 (urea transporter), membe...
    		 41(a)
    		 possible ortholog
    		 5(54986975-54990608)


    ENSEMBL Gene Tree for SLC14A1 (if available)
    TreeFam Gene Tree for SLC14A1 (if available) 

    Paralogs
    for SLC14A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC14A1 gene
    SLC14A22  
    5 SIMAP similar genes for SLC14A1 using alignment to 27 protein entries:     UT1_HUMAN (see all proteins):
    HUT11    UT-B1    SLC14A1 JK    JK    SLC14A2

    SLC14A1 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC14A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336
    Polymorphism: SLC14A1 is responsible for the Kidd blood group system (JK) [MIM:111000]. JK is defined by 2 alleles,
    JK*01 and JK*02 that give rise to Jk(a) and Jk(b) antigens respectively. The molecular basis of the Jk(a)/Jk(b)
    antigens is a single variation in position 280; Asp-280 corresponds to Jk(a) and Asn-280 to Jk(b). Some individuals
    carry silenced JK*01 and JK*02 alleles, designated JK*01N or JK*02N. They results in a Jk(null) phenotype associated
    with reduced urea permeability of red blood cells. Jk(null) is not associated with any obvious clinical syndrome
    except for a urine concentration defect


    10/709 NCBI SNPs in SLC14A1 are shown (see all 709)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10583961,2
    		C,F,A,H,non-pathogenic42624970(+) TTGAGG/AACATC 8 /N /D mis141Minor allele frequency- A:0.41MN NA NS EA WA CSA EU 9625
    rs782429491,2
    		C,pathogenic42624937(+) ACAGCC/TCTCTG 8 P S mis10--------
    rs289594791,2
    		C,F--40159461(+) GAAAGG/ACCAGG 3 -- us2k1 tfbs3 trp35Minor allele frequency- A:0.02NS NA CSA 100
    rs289594801,2
    		C,F,--40159547(+) AGTGCG/AACTGA 3 -- us2k16Minor allele frequency- A:0.03NS NA CSA WA 218
    rs289594811,2
    		C,--40159561(+) AGAAGG/ACTCCA 3 -- us2k15Minor allele frequency- A:0.01NS NA WA 216
    rs289594821,2
    		C,--40159566(+) GCTCCA/GTGGGT 3 -- us2k15Minor allele frequency- G:0.02NS NA WA 216
    rs99623961,2
    		C,H,--40160037(+) GAGATT/CTGCCT 3 -- us2k17Minor allele frequency- C:0.01NS EA WA 628
    rs116607811,2
    		H--40160390(+) tatgtA/Gtatat 3 -- us2k10--------
    rs116608381,2
    		H--40160396(+) tatatA/Gtatat 3 -- us2k10--------
    rs116608551,2
    		H--40160411(+) tatatA/Gtatat 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC14A1 (43304092 - 43332485 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC14A1: --
    Human Gene Mutation Database (HGMD): SLC14A1

    Locus Specific Mutation Databases (LSDB): SLC14A1
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC14A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC14A1

    Disorders / Diseases
    for SLC14A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC14A1 for disorders           About GeneDecksing

    OMIM gene information: 613868    OMIM disorders: --

    4 diseases for SLC14A1:    About MalaCards
    hydrops fetalis    urinary bladder cancer    bladder cancer susceptibility    huntington's disease

    1 Novoseek disease relationship for SLC14A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemolysis 36.1 1 11841450 (1)

    Genetic Association Database (GAD): SLC14A1
    Human Genome Epidemiology (HuGE) Navigator: SLC14A1 (9 documents)

    Export disorders for SLC14A1 gene to outside databases

    Publications
    for SLC14A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC14A1 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with SLC14A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic characterization of the Kidd blood group gene: different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns. (PubMed id 10644814)1, 2, 9 Irshaid N.M.... Olsson M.L. (2000)
    2. Kidd blood group and urea transport function of human erythrocytes are carried by the same protein. (PubMed id 7797558)1, 3, 9 Olives B....Bailly P. (1995)
    3. At physiological expression levels, the Kidd blood group/urea transporter protein is not a water channel. (PubMed id 10514515)1, 2, 9 Sidoux-Walter F.... Bailly P. (1999)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genetic characterization of the population of Grande Comore Island (Njazidja) according to major blood groups. (PubMed id 15754970)1, 4 Chiaroni J....Boetsch G. (2004)
    6. A molecular genetic analysis of the Kidd blood group polymorphism in Taiwanese, Thais, and Filipinos. (PubMed id 11852461)1, 4 Liu T.C....Chang J.G. (2001)
    7. Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns. (PubMed id 10942407)1, 2 Sidoux-Walter F.... Bailly P. (2000)
    8. The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility. (PubMed id 9215669)1, 2 Olives B.... Merriman T. (1997)
    9. RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation. (PubMed id 8573795)1, 2 Davey S. and Beach D. (1995)
    10. Cloning and functional expression of a urea transporter from human bone marrow cells. (PubMed id 7989337)1, 2 Olives B.... Ripoche P. (1994)

    External Searches for SLC14A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC14A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6563 HGNC: 10918 AceView: SLC14A1 Ensembl:ENSG00000141469 euGenes: HUgn6563
    ECgene: SLC14A1 H-InvDB: SLC14A1

    Other Databases showing SLC14A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC14A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC14A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC14A1 Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=kidd
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC14A1
    SeattleSNPshttp://pga.gs.washington.edu/data/slc14a1/

    Intellectual Property
    for SLC14A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC14A1 gene:
    Search GeneIP for patents involving SLC14A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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