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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC14A1 Gene

protein-coding   GIFtS: 61
GCID: GC18P043304

Solute Carrier Family 14 (Urea Transporter), Member 1

(Previous name: Kidd blood group)
(Previous symbol: JK)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 14 (Urea Transporter), Member 11 2     RACH22
JK1 2 3     UT-B12
Kidd Blood Group1 2     SLC14A1 JK2
Urea Transporter, Erythrocyte2 3     Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group)2
HUT112 3     Urea Transporter 12
RACH12 3     Urea Transporter JK Glycoprotein2
UT12 3     Urea Transporter-B12
UTE2 3     Solute Carrier Family 14 Member 13
HsT13412     

External Ids:    HGNC: 109181   Entrez Gene: 65632   Ensembl: ENSG000001414697   OMIM: 6138685   UniProtKB: Q133363   

Export aliases for SLC14A1 gene to outside databases

Previous GC identifers: GC18P043616 GC18P043090 GC18P043193 GC18P041556 GC18P041558 GC18P040161


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC14A1 Gene:
The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene
forms the basis for the Kidd blood group system. (provided by RefSeq, Mar 2009)

GeneCards Summary for SLC14A1 Gene: 
SLC14A1 (solute carrier family 14 (urea transporter), member 1) is a protein-coding gene. Diseases associated with SLC14A1 include bladder cancer susceptibility, and hydrops fetalis, and among its related super-pathways are Transmembrane transport of small molecules and Na+/Cl- dependent neurotransmitter transporters. GO annotations related to this gene include urea transmembrane transporter activity and ammonium transmembrane transporter activity. An important paralog of this gene is SLC14A2.

UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336
Function: Mediates urea transport in erythrocytes (By similarity). Low-affinity facilitative urea transporter that
allow rapid equilibration between the urinary space and the hyperosmotic interstitium. the rate of urea
conduction is increased by hypoosmotic stress

Gene Wiki entry for SLC14A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC14A1 gene promoter:
         Max1   SREBP-1c   Bach2   LUN-1   C/EBPalpha   RORalpha1   PPAR-gamma1   HOXA5   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC14A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC14A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC14A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11-q12   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q11-q12

SLC14A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC14A1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P043304:  view genomic region     (about GC identifiers)

Start:
43,304,092 bp from pter      End:
43,332,485 bp from pter
Size:
28,394 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336 (See protein sequence)
Recommended Name: Urea transporter 1  
Size: 389 amino acids; 42528 Da
Subunit: Homotrimer (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane (By
similarity)
Secondary accessions: A8K0P3 B3KR62 B3KVX3 C9EHF2 Q86VM5
Alternative splicing: 2 isoforms:  Q13336-1   Q13336-2   

Explore the universe of human proteins at neXtProt for SLC14A1: NX_Q13336

Explore proteomics data for SLC14A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13336

  • SLC14A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC14A1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001122060.3  NP_001139508.2  NP_001139509.1  NP_056949.4  

    ENSEMBL proteins: 
     ENSP00000318546   ENSP00000465029   ENSP00000442180   ENSP00000465702   ENSP00000466273  
     ENSP00000412309   ENSP00000441998   ENSP00000385320   ENSP00000467898   ENSP00000470055  
     ENSP00000390637   ENSP00000466093   ENSP00000468763   ENSP00000470476   ENSP00000465044  
     ENSP00000465150   ENSP00000465892  
    Reactome Protein details: Q13336
    Human Recombinant Protein Products for SLC14A1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7989337
    GO:0016021integral to membrane ----
    GO:0016323basolateral plasma membrane IEA--

    SLC14A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bloodgroup: Blood group antigens
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Erythrocyte urea transporter 
    SLC14 family of facilitative urea transporters

    1 InterPro protein domain:
     IPR004937 Urea_transporter

    Graphical View of Domain Structure for InterPro Entry Q13336

    ProtoNet protein and cluster: Q13336

    1 Blocks protein domain: IPB004937 Urea transporter


    SLC14A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UT1_HUMAN, Q13336
    Function: Mediates urea transport in erythrocytes (By similarity). Low-affinity facilitative urea transporter that
    allow rapid equilibration between the urinary space and the hyperosmotic interstitium. the rate of urea
    conduction is increased by hypoosmotic stress

         Genatlas biochemistry entry for SLC14A1:
    solute carrier family 14 (urea transport),member 1,36kDa,erythroid,same as Kidd (JK),see symbol

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005372water transmembrane transporter activity IEA--
    GO:0015204urea transmembrane transporter activity IEA--
         
    SLC14A1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc14a1):
     behavior/neurological  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  renal/urinary system  reproductive system 

    SLC14A1 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC14A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Amine compound SLC transporters
    Amine compound SLC transporters0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC14A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Amine compound SLC transporters



    SLC14A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC14A1

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006833water transport ----
    GO:0015840urea transport TAS7989337
    GO:0055085transmembrane transport TAS--
    GO:0071918urea transmembrane transport ----

    SLC14A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC14A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC14A1 (UT1)

    1 HMDB Compound for SLC14A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    UreaCarbonyl diamine (see all 90)57-13-6--

    2 Novoseek inferred chemical compound relationships for SLC14A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urea 71.8 28 9582331 (4), 8542029 (2), 11841450 (2), 10514515 (2) (see all 11)
    vas-a 67.6 5 8995727 (3), 9582331 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC14A1 / UT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC14A1 gene (4 alternative transcripts): 
    NM_001128588.3  NM_001146036.2  NM_001146037.1  NM_015865.6  

    Unigene Cluster for SLC14A1:

    Solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
    Hs.101307  [show with all ESTs]
    Unigene Representative Sequence: NM_001146037
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000321925(uc002lbi.4 uc002lbf.4 uc010xco.2 uc002lbk.4 uc021ujg.1)
    ENST00000587601 ENST00000502059 ENST00000586951 ENST00000589322 ENST00000415427(uc010dnk.3 uc010xcn.2 uc002lbg.4 uc002lbh.4)
    ENST00000535474 ENST00000402943 ENST00000588179 ENST00000586056 ENST00000436407(uc002lbj.4)
    ENST00000589891 ENST00000590246 ENST00000591943 ENST00000586142 ENST00000589700
    ENST00000590377 ENST00000591642
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    Additional mRNA sequence: 

    AF263545.1 AF328892.1 AK091064.1 AK289608.1 AK294129.1 AK295268.1 BC050539.1 GQ502682.1 
    HQ709264.1 L36121.1 U35735.1 Y19039.1 

    10 DOTS entries:

    DT.111587  DT.75101356  DT.101983510  DT.95108081  DT.101983511  DT.92421881  DT.95161079  DT.95161080 
    DT.95161081  DT.91824779 

    24/104 AceView cDNA sequences (see all 104):

    AI056236 T08809 AK091064 N47509 AI684202 AX746761 AF328892 AW472964 
    AA857758 Y19039 R98010 CA428601 AI431860 BF512246 N47686 L36121 
    BU657117 BC040128 AK127452 BQ774962 AW069778 AU098386 AI424436 BC050539 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SLC14A1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
    SP1:                          -           -     -     -     -     -     -                       -                                                     -         
    SP2:                          -           -                       -     -     -     -     -     -                                                     -         
    SP3:                                                              -     -                       -                                                     -         
    SP4:                          -           -     -     -     -     -     -     -     -     -     -                                                     -         
    SP5:                                                                                            -                                                     -         

    ExUns: 10c ^ 11 ^ 12a · 12b · 12c · 12d · 12e
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SLC14A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC14A1 expression in normal human tissues (normalized intensities)      SLC14A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAATTAT
    SLC14A1 Expression
    About this image


    SLC14A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Mesenchymal Stem Cells
             Umbilical cord blood-derived mesenchymal stem cells
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Growth Plate
             Human fetal bone marrow-derived mesenchymal stromal cells
             Human Vertebral Mesenchymal Stem Cells (HVMSC)   
             sensory organ/ear/inner ear   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             visceral organ/urethra of male/pelvic urethra of male   

    See SLC14A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC14A1

    SOURCE GeneReport for Unigene cluster: Hs.101307

    UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336
    Tissue specificity: Erythrocytes

        SABiosciences Expression via Pathway-Focused PCR Array including SLC14A1: 
              Huntington's Disease in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC14A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC14A1 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc14a11 , 5 solute carrier family 14 (urea transporter), member more1, 5 83.41(n)1
    82.05(a)1
      18 (52.49 cM)5
    1080521  NM_001171010.11  NP_001164481.11 
     781000915 
    zebrafish
    (Danio rerio)
    Actinopterygii slc14a26
    solute carrier family 14 (urea transporter), membe...
    41(a)
    1 → many
    5(54986975-54990608)


    ENSEMBL Gene Tree for SLC14A1 (if available)
    TreeFam Gene Tree for SLC14A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC14A1 gene
    SLC14A22  
    5 SIMAP similar genes for SLC14A1 using alignment to 27 protein entries:     UT1_HUMAN (see all proteins):
    HUT11    UT-B1    SLC14A1 JK    JK    SLC14A2

    SLC14A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: UT1_HUMAN, Q13336
    Polymorphism: SLC14A1 is responsible for the Kidd blood group system (JK) [MIM:111000]. JK is defined by 2
    alleles, JK*01 and JK*02 that give rise to Jk(a) and Jk(b) antigens respectively. The molecular basis of the
    Jk(a)/Jk(b) antigens is a single variation in position 280; Asp-280 corresponds to Jk(a) and Asn-280 to Jk(b).
    Some individuals carry silenced JK*01 and JK*02 alleles, designated JK*01N or JK*02N. They results in a Jk(null)
    phenotype associated with reduced urea permeability of red blood cells. Jk(null) is not associated with any
    obvious clinical syndrome except for a urine concentration defect


    10/832 SNPs in SLC14A1 are shown (see all 832)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10583961,2,4
    C,F,A,Hnon-pathogenic143298334(+) TTGAGG/AACATC 8 /N /D mis141Minor allele frequency- A:0.41MN NA NS EA WA CSA EU 9625
    rs782429491,2,4
    Cpathogenic143298367(+) ACAGCC/TCTCTG 8 P S mis10--------
    VAR_0654684
    ----see VAR_0654682 T M mis40--------
    VAR_0654674
    ----see VAR_0654672 G E mis40--------
    VAR_0654664
    ----see VAR_0654662 N K mis40--------
    rs674246231,2
    C--40160356(+) ACACA-/AC/CA 
            
    TATAT
    3 -- us2k10--------
    rs116607811,2
    H--40160390(+) tatgtA/Gtatat 3 -- us2k10--------
    rs116608381,2
    H--40160396(+) tatatA/Gtatat 3 -- us2k10--------
    rs672852831,2
    C--40160431(+) TATAC-/ATGT  
            
    ATGTA
    3 -- us2k10--------
    rs290016221,2
    F--40188463(+) AAAAACAAAAC  
      AAAA
    /-
    CAAAA
    8 -- ut312Minor allele frequency- -:0.09NS 92

    HapMap Linkage Disequilibrium report for SLC14A1 (43304092 - 43332485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC14A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv909586CNV Gain21882294
    nsv525268CNV Gain19592680
    nsv909587CNV Gain21882294


    Human Gene Mutation Database (HGMD): SLC14A1

    Locus Specific Mutation Databases (LSDB): SLC14A1
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC14A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC14A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613868    OMIM disorders: --

    8 diseases for SLC14A1:    About MalaCards
    bladder cancer susceptibility    hydrops fetalis    hyperparathyroidism    huntington's disease
    type 1 diabetes    lung adenocarcinoma    adenocarcinoma    endotheliitis


    SLC14A1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC14A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemolysis 36.1 1 11841450 (1)

    Genetic Association Database (GAD): SLC14A1
    Human Genome Epidemiology (HuGE) Navigator: SLC14A1 (9 documents)

    Export disorders for SLC14A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC14A1 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with SLC14A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic characterization of the Kidd blood group gene: different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns. (PubMed id 10644814)1, 2, 9 Irshaid N.M.... Olsson M.L. (2000)
    2. Kidd blood group and urea transport function of human erythrocytes are carried by the same protein. (PubMed id 7797558)1, 3, 9 Olives B....Bailly P. (1995)
    3. At physiological expression levels, the Kidd blood group/urea transporter protein is not a water channel. (PubMed id 10514515)1, 2, 9 Sidoux-Walter F.... Bailly P. (1999)
    4. European genome-wide association study identifies SLC 14A1 as a new urinary bladder cancer susceptibility gene. (PubMed id 21750109)1, 4 Rafnar T....Kiemeney L.A. (2011)
    5. A genome-wide association study of bladder cancer ide ntifies a new susceptibility locus within SLC14A1, a urea transporter gene on c hromosome 18q12.3. (PubMed id 21824976)1, 4 Garcia-Closas M....Wu X. (2011)
    6. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Introduction of a real-time based blood group genotyping approach. (PubMed id 18510579)1, 4 Polin H....Gabriel C. (2008)
    9. ABO, Rh, MNS, Duffy, Kidd,Yt, Scianna, and Colton blood group systems in indigenous Chinese. (PubMed id 15783300)1, 4 Yan L....He J. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6563 HGNC: 10918 AceView: SLC14A1 Ensembl:ENSG00000141469 euGenes: HUgn6563
    ECgene: SLC14A1 H-InvDB: SLC14A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC14A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC14A1 Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=kidd
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC14A1
    SeattleSNPshttp://pga.gs.washington.edu/data/slc14a1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC14A1 gene:
    Search GeneIP for patents involving SLC14A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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