Aliases for SLC14A1 Gene
External Ids for SLC14A1 Gene
Previous Symbols for SLC14A1 Gene
The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]
GeneCards Summary for SLC14A1 Gene
SLC14A1 (Solute Carrier Family 14 (Urea Transporter), Member 1 (Kidd Blood Group)) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include water transmembrane transporter activity and urea transmembrane transporter activity. An important paralog of this gene is SLC14A2.
UniProtKB/Swiss-Prot for SLC14A1 Gene
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means