Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC13A5 Gene

protein-coding   GIFtS: 55
GCID: GC17M006588

Solute Carrier Family 13 (Sodium-Dependent Citrate Transporter),...
  Search for SLC13A5
at
MalaCards
 

Aliases
for SLC13A5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Solute Carrier Family 13 (Sodium-Dependent Citrate Transporter), Member
51 2
     Na(+)/Citrate Cotransporter2 3
NACT2 3 5     Solute Carrier Family 13 Member 52
Sodium-Coupled Citrate Transporter2 3     Solute Carrier Family 13, Member 52
Sodium-Dependent Citrate Transporter2 3     NaCT3

External Ids:    HGNC: 230891   Entrez Gene: 2841112   Ensembl: ENSG000001414857   OMIM: 6083055   UniProtKB: Q86YT53   

Export aliases for SLC13A5 gene to outside databases

Previous GC identifers: GC17M006532 GC17M006788 GC17M006529 GC17M006483


Summaries
for SLC13A5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC13A5 Gene:
SLC13A5 is a tricarboxylate plasma transporter with a preference for citrate.(supplied by OMIM, Apr 2004)

GeneCards Summary for SLC13A5 Gene: 
SLC13A5 (solute carrier family 13 (sodium-dependent citrate transporter), member 5) is a protein-coding gene. Among its related super-pathways are Transmembrane transport of small molecules and Sodium-coupled sulphate, di- and tri-carboxylate transporters. GO annotations related to this gene include succinate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC13A4.

UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5
Function: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is
electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May
facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of
fatty acids and cholesterol




Genomic Views
for SLC13A5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC13A5 gene promoter:
         AhR   GATA-3   GATA-1   Arnt   AREB6   E2F-1   E2F   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC13A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC13A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC13A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

SLC13A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC13A5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M006588:  view genomic region     (about GC identifiers)

Start:
 6,588,032 bp from pter      End:
 6,616,886 bp from pter
Size:
 28,855 bases      Orientation:
 minus strand

Proteins
for SLC13A5 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5 (See protein sequence)
Recommended Name: Solute carrier family 13 member 5  
Size: 568 amino acids; 63062 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B7ZLB4 Q6ZMG1
Alternative splicing: 2 isoforms:  Q86YT5-1   Q86YT5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC13A5: NX_Q86YT5

Explore proteomics data for SLC13A5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YT5

    • SLC13A5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC13A5 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001137310.1  NP_001271438.1  NP_001271439.1  NP_808218.1  

    ENSEMBL proteins: 
     ENSP00000406220   ENSP00000293800   ENSP00000370464   ENSP00000459372   ENSP00000460037  
     ENSP00000466899   ENSP00000461495   ENSP00000461622   ENSP00000461554   ENSP00000460903  
    Reactome Protein details: Q86YT5
    Human Recombinant Protein Products for SLC13A5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC13A5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC13A5
    GenScript Custom Purified and Recombinant Proteins Services for SLC13A5
    Novus Biologicals SLC13A5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC13A5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane IEA--

    SLC13A5 for ontologies           About GeneDecksing



    SLC13A5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC13A5
    GenScript Custom Superior Antibodies Services for SLC13A5
    Novus Biologicals SLC13A5 Antibodies
    Abcam antibodies for SLC13A5
    Cloud-Clone Corp. Antibodies for SLC13A5 
    ThermoFisher Antibodies for SLC13A5
    LSBio Antibodies in human, mouse, rat for SLC13A5 

    Assay Products for SLC13A5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC13A5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC13A5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC13A5 
    Cloud-Clone Corp. CLIAs for SLC13A5

    Protein Domains /
    Families
    for SLC13A5 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Na+/citrate cotransporter 
    SLC13 family of sodium-dependent sulphate/carboxylate transporters

    1 InterPro protein domain:
     IPR001898 Na/sul_symport

    Graphical View of Domain Structure for InterPro Entry Q86YT5

    ProtoNet protein and cluster: Q86YT5

    1 Blocks protein domain: IPB001898 Sodium/sulphate symporter

    UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5
    Similarity: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily


    SLC13A5 for domains           About GeneDecksing


    Function
    for SLC13A5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S13A5_HUMAN, Q86YT5
    Function: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is
    electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May
    facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of
    fatty acids and cholesterol

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005343organic acid:sodium symporter activity ----
    GO:0015137citrate transmembrane transporter activity IEA--
    GO:0015141succinate transmembrane transporter activity IEA--
    GO:0015142tricarboxylic acid transmembrane transporter activity ----
         
    SLC13A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC13A5:
     Proliferating cells 

         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Slc13a5):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system 
     muscle  no phenotypic analysis 

    SLC13A5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC13A5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC13A5

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC13A5
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC13A5:
    hsa-miR-4303 hsa-miR-9 hsa-miR-122 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmid: SLC13A5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC13A5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC13A5
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC13A5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC13A5
    Sirion Biotech Customized adenovirus for overexpression of SLC13A5
                         Customized adenovirus for potent knockdown of SLC13A5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC13A5 (see all 13)
    OriGene ORF clones in mouse, rat for SLC13A5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC13A5 (NM_177550)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC13A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC13A5

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC13A5
    Search LifeMap BioReagents cell lines for SLC13A5
    Sirion Biotech Customized stable knockdown cell line services for SLC13A5
                         Customized inducible knockdown cell line services for SLC13A5
                         Customized stable overexpressing cell line services for SLC13A5
                         Customized inducible overexpressing cell line services for SLC13A5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5


    Pathways & Interactions
    for SLC13A5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC13A5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport0.50
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Bile salt and organic anion SLC transporters
    		Bile salt and organic anion SLC transporters0.42
    		Sodium-coupled sulphate, di- and tri-carboxylate transporters0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SLC13A5
        Sodium-coupled sulphate, di- and tri-carboxylate transporters
    Bile salt and organic anion SLC transporters
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds



    SLC13A5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC13A5

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport ----
    GO:0006842tricarboxylic acid transport ----
    GO:0015744succinate transport ----
    GO:0015746citrate transport ----
    GO:0035674tricarboxylic acid transmembrane transport ----

    SLC13A5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC13A5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC13A5 (S13A5)

    1 HMDB Compound for SLC13A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about SLC13A5 / S13A5

    Transcripts
    for SLC13A5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC13A5 gene (4 alternative transcripts): 
    NM_001143838.2  NM_001284509.1  NM_001284510.1  NM_177550.4  

    Unigene Cluster for SLC13A5:

    Solute carrier family 13 (sodium-dependent citrate transporter), member 5
    Hs.399496  [show with all ESTs]
    Unigene Representative Sequence: BX647354
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433363(uc002gdj.3 uc010vtf.2 uc010clq.3 uc002gdk.3)
    ENST00000574580 ENST00000293800 ENST00000381074 ENST00000573648 ENST00000570687
    ENST00000572727 ENST00000574824(uc002gdl.1) ENST00000572094 ENST00000572352
    ENST00000576323 ENST00000575230
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC13A5
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC13A5:
    hsa-miR-4303 hsa-miR-9 hsa-miR-122 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmid: SLC13A5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC13A5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC13A5
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC13A5
    Clone
    Products:             		 OriGene clones in human, mouse for SLC13A5 (see all 13)
    OriGene ORF clones in mouse, rat for SLC13A5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC13A5 (NM_177550)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC13A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC13A5
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for SLC13A5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC13A5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC13A5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC13A5

    Additional mRNA sequence: 

    AJ489980.1 AK124317.1 AK127797.1 AK131206.1 AK172779.1 AK172785.1 AK297612.1 AY151833.1 
    BC104795.1 BC112151.1 BC143689.1 BX647354.1 CR749584.1 

    8 DOTS entries:

    DT.215029  DT.40296888  DT.99942300  DT.100738015  DT.100000016  DT.102824130  DT.100648227  DT.92416972 

    24/59 AceView cDNA sequences (see all 59):

    AK127797 Z45042 BX445866 BQ647893 Z40774 BX427572 AK172785 BX463054 
    BX951550 AI955606 AW297488 NM_177550 BQ654357 BX485821 AW297485 CR749584 
    BX431856 CB156857 U92029 AK172779 BX951552 BQ654393 AK131206 AY151833 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A5 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -           -     -                                   -                             -               
    SP2:                                -           -                                         -                             -               
    SP3:                                -           -                                                                                       
    SP4:                    -     -     -           -                                         -                                             
    SP5:                                                                                      -                                             


    ECgene alternative splicing isoforms for SLC13A5

    Expression
    for SLC13A5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC13A5 expression in normal human tissues (normalized intensities)      SLC13A5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGACAAGC
    SLC13A5 Expression
    About this image


    SLC13A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Growth Plate
             Chondrocyte-like cells (Generation of chondrocytes from human fetal mesenchymal stromal...
             bone marrow
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocyte-like cells (Generation of chondrocytes from human fetal mesenchymal stromal...
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland
     
     Blood (Cardiovascular System)
             bone marrow
     
     Ear (Sensory Organs)
             stria vascularis

    See SLC13A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC13A5

    SOURCE GeneReport for Unigene cluster: Hs.399496

    UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5
    Tissue specificity: Expressed most predominantly in the liver, with moderate expression detectable in the brain and
    testis

        SABiosciences Custom PCR Arrays for SLC13A5
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for SLC13A5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC13A5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC13A5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC13A5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5

    Orthologs
    for SLC13A5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC13A5 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc13a51 , 5 solute carrier family 13 (sodium-dependent citrate more1, 5 80.11(n)1
    75(a)1    		   11 (43.95 cM)5
    2378311  NM_001004148.41  NP_001004148.11 
     722419945 
    chicken
    (Gallus gallus)    		 Aves SLC13A51 solute carrier family 13 (sodium-dependent citrate more 65.14(n)
    65.45(a)    		   417678  XM_003642418.1  XP_003642466.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC13A56
    		 Uncharacterized protein
    		 67(a)
    		 1 ↔ 1
    		 AAWZ02039898(2012-7443)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-221p4.41 si:ch211-221p4.4 65.19(n)
    63.12(a)    		   503788  NM_001142566.1  NP_001136038.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Indy-26
    Indy6
    (see all 4)    		 I'm not dead yet
    (see all 4)    		 33(a)
    33(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 3R(15868479-15874438)
    3L(18821732-18839367)
    worm
    (Caenorhabditis elegans)    		 Secernentea nac-11 Protein NAC-1 48.49(n)
    42.83(a)    		   181585  NM_078072.2  NP_510473.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PHO91(YNR013C)4 Low-affinity phosphate transporter of the vacuolar more   --   14(651712-649028) 855747  NP_014410.1 


    ENSEMBL Gene Tree for SLC13A5 (if available)
    TreeFam Gene Tree for SLC13A5 (if available)

    Paralogs
    for SLC13A5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC13A5 gene
    SLC13A42  SLC13A12  SLC13A22  SLC13A32  
    5 SIMAP similar genes for SLC13A5 using alignment to 9 protein entries:     S13A5_HUMAN (see all proteins):
    DKFZp686E17257    SLC13A2    SLC13A3    SLC13A1    SLC13A4

    SLC13A5 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC13A5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/820 SNPs in SLC13A5 are shown (see all 820)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1852318781,2
    		--6587574(+) CCACCC/GTGTCT 2 -- ds50010--------
    rs601278251,2
    		C,F--6587576(+) ACCCTG/CTCTCA 2 -- ds50012Minor allele frequency- C:0.06WA 120
    rs1908774001,2
    		--6587631(+) GGACTC/TATGTT 2 -- ds50010--------
    rs1167727801,2
    		C,F--6587638(+) TGTTTG/TGAGAT 2 -- ds50011Minor allele frequency- T:0.06WA 118
    rs577917211,2
    		C,F--6587649(+) CTTCCC/GTTGGC 2 -- ds50012Minor allele frequency- G:0.07WA 120
    rs1833884161,2
    		C--6587657(+) GGCATA/GGACTT 2 -- ds50010--------
    rs1165408191,2
    		F--6587660(+) ATGGAC/TTTGCT 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1451173811,2
    		--6587793(+) TGTGAA/CTTTGG 2 -- ds50010--------
    rs1471454931,2
    		--6587861(+) TAACAC/GCTTCC 2 -- ds50010--------
    rs2010048161,2
    		C--6587875(+) CTCAC-/GGGTTG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC13A5 (6588032 - 6616886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC13A5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv907631CNV Loss21882294
    nsv907630CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC13A5
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC13A5

    Disorders / Diseases
    for SLC13A5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC13A5 for disorders           About MalaCards

    SLC13A5 for disorders           About GeneDecksing

    OMIM gene information: 608305    OMIM disorders: --

    Genetic Association Database (GAD): SLC13A5
    Human Genome Epidemiology (HuGE) Navigator: SLC13A5 (1 document)

    Export disorders for SLC13A5 gene to outside databases

    Publications
    for SLC13A5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC13A5 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SLC13A5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function. (PubMed id 12445824)1, 2, 3, 9 Inoue K.... Ganapathy V. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. (PubMed id 12826022)1, 9 Inoue K....Ganapathy V. (2003)
    6. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    7. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    8. Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. (PubMed id 16973915)1 Gopal E....Ganapathy V. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. (PubMed id 16211368)1 Pajor A.M. (2006)

    External Searches for SLC13A5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC13A5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284111 HGNC: 23089 AceView: SLC13A5 Ensembl:ENSG00000141485 euGenes: HUgn284111
    ECgene: SLC13A5 H-InvDB: SLC13A5

    Other Databases showing SLC13A5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC13A5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC13A5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC13A5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC13A5 gene:
    Search GeneIP for patents involving SLC13A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SLC13A5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC13A5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SLC13A5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC13A5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC13A5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC13A5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC13A5   OriGene Custom Protein Services for SLC13A5  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC13A5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC13A5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC13A5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC13A5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC13A5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC13A5
     GenScript Custom Purified and Recombinant Proteins Services for SLC13A5 GenScript cDNA clones with any tag delivered in your preferred vector for SLC13A5
     GenScript Custom Assay Services for SLC13A5 GenScript Custom Superior Antibodies Services for SLC13A5
     GenScript Custom overexpressing Cell Line Services for SLC13A5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC13A5 promoter
     Search Chromatin IP Primers for SLC13A5
     RT2 qPCR Primer Assay in human, mouse, rat SLC13A5
     Search GNC Networks for SLC13A5
     SABiosciences Custom PCR Arrays for SLC13A5
     Search Tocris compounds for SLC13A5 (S13A5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC13A5 antibodies
     SLC13A5 proteins
     Antibodies for SLC13A5
     See all of Abcam's Antibodies, Kits and Proteins for SLC13A5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC13A5
     Antibodies for SLC13A5
     ELISAs for SLC13A5
     CLIAs for SLC13A5
     Search LifeMap BioReagents cell lines for SLC13A5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5
     SwitchGear 3'UTR luciferase reporter plasmids for SLC13A5
     SwitchGear Promoter luciferase reporter plasmids for SLC13A5
     ThermoFisher Antibodies for SLC13A5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC13A5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC13A5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC13A5
    Customized:
     stable knockdown cell line services for SLC13A5
     inducible knockdown cell line services for SLC13A5
     design and validation of potent shRNA sequences against SLC13A5
     adenovirus for potent knockdown of SLC13A5
     stable overexpressing cell line services for SLC13A5
     inducible overexpressing cell line services for SLC13A5
     adenovirus for overexpression of SLC13A5
     LSBio Antibodies in human, mouse, rat for SLC13A5
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SLC13A5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4