SLC13A5 Gene

Aliases
for SLC13A5 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17M006532 GC17M006788 GC17M006529 GC17M006483

Summaries
for SLC13A5 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SLC13A5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NT_010718.17  NC_018928.2  

SwitchGear Promoter luciferase reporter plasmid: SLC13A5 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC13A5

SLC13A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M006588:  view genomic region     (about GC identifiers)

Proteins
for SLC13A5 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for SLC13A5: NX_Q86YT5

Explore proteomics data for SLC13A5 at MOPED

Post-translational modifications: 

SLC13A5 Human Recombinant Protein Products:

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	antibodies-online kits for SLC13A5 (6 products)

Domains /
Families
for SLC13A5 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q86YT5

Find genes that share domains with SLC13A5           About GenesLikeMe

Function
for SLC13A5 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

(inferred from 3 alleles) (MGI details for Slc13a5)

genOway: Develop your customized and physiologically relevant rodent model for SLC13A5

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		SwitchGear 3'UTR luciferase reporter plasmid: SLC13A5 3' UTR sequence

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLC13A5

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5

Localization
for SLC13A5 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for SLC13A5 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for SLC13A5 About     See pathways by source

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	SuperPath	Contained pathways About
1	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	SLC-mediated transmembrane transport 0.47 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.38 Transmembrane transport of small molecules 0.47 Sodium-coupled sulphate, di- and tri-carboxylate transporters 0.00

1 Reactome Pathway for SLC13A5

Sodium-coupled sulphate, di- and tri-carboxylate transporters

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for SLC13A5 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for SLC13A5 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SLC13A5 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC13A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGAGACAAGC

About this image

Bone (Muscoskeletal System)    fully expand to see all 5 entries
Zeugopod Growth Plate
Chondrocyte-like cells
Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
Chondrocyte-like cells

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5

Orthologs
for SLC13A5 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SLC13A5 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for SLC13A5 gene

SLC13A4²  SLC13A1²  SLC13A2²  SLC13A3²  

5 SIMAP similar genes for SLC13A5 using alignment to 9 protein entries:     S13A5_HUMAN (see all proteins):

DKFZp686E17257    SLC13A2    SLC13A3    SLC13A1    SLC13A4

Find genes that share paralogs with SLC13A5           About GenesLikeMe

Genomic Variants
for SLC13A5 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC13A5 (see all 820)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1852318781,2		--	6587574(+)	CCACCC/GTGTCT	2	--	ds5001		0	--	--	--	--
rs601278251,2	C,F	--	6587576(+)	ACCCTG/CTCTCA	2	--	ds5001		2		WA	120
rs1908774001,2		--	6587631(+)	GGACTC/TATGTT	2	--	ds5001		0	--	--	--	--
rs1167727801,2	C,F	--	6587638(+)	TGTTTG/TGAGAT	2	--	ds5001		1		WA	118
rs577917211,2	C,F	--	6587649(+)	CTTCCC/GTTGGC	2	--	ds5001		2		WA	120
rs1833884161,2	C	--	6587657(+)	GGCATA/GGACTT	2	--	ds5001		0	--	--	--	--
rs1165408191,2	F	--	6587660(+)	ATGGAC/TTTGCT	2	--	ds5001		1		WA	118
rs1451173811,2		--	6587793(+)	TGTGAA/CTTTGG	2	--	ds5001		0	--	--	--	--
rs1471454931,2		--	6587861(+)	TAACAC/GCTTCC	2	--	ds5001		0	--	--	--	--
rs2010048161,2	C	--	6587875(+)	CTCAC-/GGGTTG	2	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC13A5 (6588032 - 6616886 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for SLC13A5:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv907631	CNV	Loss	21882294
nsv907630	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SLC13A5

DNA2.0 Custom Variant and Variant Library Synthesis for SLC13A5

Disorders / Diseases
for SLC13A5 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for SLC13A5 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function. (PubMed id 12445824)^{1, 2, 3, 9} Inoue K.... Ganapathy V. (Biochem. Biophys. Res. Commun. 2002)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. (PubMed id 12826022)^{1, 9} Inoue K....Ganapathy V. (Biochem. J. 2003)
6. The genetic architecture of economic and political preferences. (PubMed id 22566634)¹ Benjamin D.J....Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
7. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (J. Proteome Res. 2009)
8. Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. (PubMed id 16973915)¹ Gopal E....Ganapathy V. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
10. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. (PubMed id 16211368)¹ Pajor A.M. (Pflugers Arch. 2006)

External Searches for SLC13A5 gene

Genome Databases showing SLC13A5 gene

Other Databases showing SLC13A5 gene

Specialized Databases showing SLC13A5 gene

Products
for SLC13A5 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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