Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC13A5 Gene

protein-coding GIFtS: 53
GCID: GC17M006588

solute carrier family 13 (sodium-dependent citrate transporter),...

Explore 4 diseases affiliated with
SLC13A5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 13 (Sodium-Dependent Citrate Transporter), Member 5¹ ²		Na(+)/Citrate Cotransporter² ³
NACT¹ ² ³ ⁵		Solute Carrier Family 13 Member 5²
Sodium-Coupled Citrate Transporter² ³		Solute Carrier Family 13, Member 5²
Sodium-Dependent Citrate Transporter² ³		NaCT³

External Ids:	HGNC: 23089¹	Entrez Gene: 284111²	Ensembl: ENSG00000141485⁷	OMIM: 608305⁵	UniProtKB: Q86YT5³

Export aliases for SLC13A5 gene to outside databases

Previous GC identifers: GC17M006532 GC17M006788 GC17M006529 GC17M006483

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC13A5:

SLC13A5 is a tricarboxylate plasma transporter with a preference for citrate.(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5

Function: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is

electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May

facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of

fatty acids and cholesterol

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC13A5 gene promoter:
AhR GATA-3 GATA-1 Arnt AREB6 E2F-1 E2F AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC13A5 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC13A5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC13A5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

SLC13A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC13A5 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M006588: view genomic region (about GC identifiers)

Start:	6,588,032 bp from pter	End:	6,616,886 bp from pter
Size:	28,855 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5 (See protein sequence)

Recommended Name: Solute carrier family 13 member 5

Size: 568 amino acids; 63062 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: B7ZLB4 Q6ZMG1

Alternative splicing: 2 isoforms: Q86YT5-1 Q86YT5-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC13A5: NX_Q86YT5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86YT5

SLC13A5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137310.1 NP_808218.1

ENSEMBL proteins:

ENSP00000406220 ENSP00000293800 ENSP00000370464 ENSP00000459372 ENSP00000460037

ENSP00000466899 ENSP00000461495 ENSP00000461622 ENSP00000461554 ENSP00000460903

Reactome Protein details: Q86YT5
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLC13A5 OriGene Custom Protein Services for SLC13A5
	GenScript Custom Purified and Recombinant Proteins Services for SLC13A5
	Novus Biologicals SLC13A5 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC13A5

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005626	insoluble fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0016323	basolateral plasma membrane	IEA	--

SLC13A5 for ontologies About GeneDecksing

SLC13A5 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLC13A5
	GenScript Custom Superior Antibodies Services for SLC13A5
	Novus Biologicals SLC13A5 Antibodies
	Search for Antibodies for SLC13A5 at Abcam
	Uscn Antibodies for SLC13A5
	ThermoFisher Antibodies for SLC13A5

Assay Products for SLC13A5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC13A5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC13A5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC13A5 for domains About GeneDecksing

1 InterPro domain/family:

IPR001898 Na/sul_symport

Graphical View of Domain Structure for InterPro Entry Q86YT5

ProtoNet protein and cluster: Q86YT5

1 Blocks protein family: IPB001898 Sodium/sulphate symporter

UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5

Similarity: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5

Function: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is

electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May

facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of

fatty acids and cholesterol

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SLC13A5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC13A5
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC13A5:
		hsa-miR-4303 hsa-miR-9 hsa-miR-122 hsa-miR-1976
		SwitchGear 3'UTR luciferase reporter plasmid: SLC13A5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC13A5 (see all 7) OriGene shRNA RFP: SLC13A5 OriGene siRNA: SLC13A5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC13A5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SLC13A5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC13A5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC13A5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SLC13A5 (NM_177550)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC13A5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC13A5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC13A5
		Search LifeMap BioReagents cell lines for SLC13A5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	--	--
GO:0005343	organic acid:sodium symporter activity	--	--
GO:0015137	citrate transmembrane transporter activity	IEA	--
GO:0015141	succinate transmembrane transporter activity	IEA	--
GO:0015142	tricarboxylic acid transmembrane transporter activity	--	--

SLC13A5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SLC13A5:

Proliferating cells

Animal Models:
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Slc13a5):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	liver/biliary system
muscle	no phenotypic analysis

SLC13A5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Bile salt and organic anion SLC transporters

Bile salt and organic anion SLC transporters

1.00

Sodium-coupled sulphate, di- and tri-carboxylate transporters

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for SLC13A5

	Sodium-coupled sulphate, di- and tri-carboxylate transporters
	Bile salt and organic anion SLC transporters
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

SLC13A5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC13A5

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006814	sodium ion transport	--	--
GO:0006842	tricarboxylic acid transport	--	--
GO:0015744	succinate transport	--	--
GO:0015746	citrate transport	--	--
GO:0035674	tricarboxylic acid transmembrane transport	--	--

SLC13A5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC13A5

1 HMDB Compound for SLC13A5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about SLC13A5 / S13A5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC13A5 gene (2 alternative transcripts):

NM_001143838.1 NM_177550.3

Unigene Cluster for SLC13A5:

Solute carrier family 13 (sodium-dependent citrate transporter), member 5

Hs.399496 [show with all ESTs]

Unigene Representative Sequence: BX647354

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000433363(uc002gdj.3 uc010vtf.2 uc010clq.3 uc002gdk.3)

ENST00000574580 ENST00000293800 ENST00000381074 ENST00000573648 ENST00000570687

ENST00000572727 ENST00000574824(uc002gdl.1) ENST00000572094 ENST00000572352

ENST00000576323 ENST00000575230

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SLC13A5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC13A5
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC13A5:
		hsa-miR-4303 hsa-miR-9 hsa-miR-122 hsa-miR-1976
		SwitchGear 3'UTR luciferase reporter plasmid: SLC13A5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC13A5 (see all 7) OriGene shRNA RFP: SLC13A5 OriGene siRNA: SLC13A5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC13A5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC13A5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC13A5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SLC13A5 (NM_177550)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC13A5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC13A5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC13A5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLC13A5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC13A5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC13A5

Additional cDNA sequence:

AJ489980.1 AK124317.1 AK127797.1 AK131206.1 AK172779.1 AK172785.1 AK297612.1 AY151833.1

BC104795.1 BC112151.1 BC143689.1 BX647354.1 CR749584.1

8 DOTS entries:

DT.215029 DT.40296888 DT.99942300 DT.100738015 DT.100000016 DT.102824130 DT.100648227 DT.92416972

24/59 AceView cDNA sequences (see all 59):

Z45042 BX445866 Z40774 AK127797 BQ647893 AW297488 AK172785 NM_177550

BQ189694 BX951550 AW297485 R93718 CR749584 BG616615 AI797218 BX951552

AK172779 BQ654393 AK131206 CB163988 BX485821 AY151833 AW592531 U92029

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A5 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14
SP1:											-				-		-												-										-
SP2:											-				-														-										-
SP3:											-				-
SP4:							-		-		-				-														-
SP5:																													-

ECgene alternative splicing isoforms for SLC13A5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC13A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGACAAGC

About this image

SLC13A5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC13A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC13A5

SOURCE GeneReport for Unigene cluster: Hs.399496

UniProtKB/Swiss-Prot: S13A5_HUMAN, Q86YT5

Tissue specificity: Expressed most predominantly in the liver, with moderate expression detectable in the brain and

testis

SABiosciences Custom PCR Arrays for SLC13A5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC13A5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLC13A5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC13A5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC13A5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC13A5 gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC13A5¹	solute carrier family 13 (sodium-dependent citrate more	65.14(n) 65.45(a)		417678 XM_003642418.1 XP_003642466.1
lizard (Anolis carolinensis)	Reptilia	SLC13A5⁶	--	67(a)	1 ↔ 1	AAWZ02039898(2012-7179)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-221p4.4¹	si:ch211-221p4.4	65.19(n) 63.12(a)		503788 NM_001142566.1 NP_001136038.1
fruit fly (Drosophila melanogaster)	Insecta	Indy⁶ Indy-2⁶ (see all 4)	I'm not dead yet 2 (see all 4)	33(a) 32(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3L(18821732-18839367) 3R(15868479-15874438)
worm (Caenorhabditis elegans)	Secernentea	nac-1¹	Protein NAC-1	48.49(n) 42.83(a)		181585 NM_078072.2 NP_510473.2
thale cress (Arabidopsis thaliana)	eudicotyledons	ATSDAT⁶	tonoplast dicarboxylate transporter	32(a)	1 → many	5(19287369-19290465)
rice (Oryza sativa)	Liliopsida	-- --	citrate transporter, putative, expressed	32(a) 32(a)	many ↔ many many ↔ many	8(24880211-24883636) 9(18714286-18717864)
E. coli (Escherichia coli)	Gamma proteobacteria	yfbS⁶	predicted transporter	13(a)	possible ortholog	Chromosome(2407542-2409374)

ENSEMBL Gene Tree for SLC13A5 (if available)
TreeFam Gene Tree for SLC13A5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC13A5 gene

SLC13A4² SLC13A1² SLC13A2² SLC13A3²

5 SIMAP similar genes for SLC13A5 using alignment to 9 protein entries: S13A5_HUMAN (see all proteins):

DKFZp686E17257 SLC13A2 SLC13A3 SLC13A1 SLC13A4

SLC13A5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185231878^1,2		--	6587574(+)	`CCACCC/GTGTCT`	2	--	ds500¹		0	--	--	--	--
rs60127825^1,2	C,	--	6587576(+)	`ACCCTG/CTCTCA`	2	--	ds500¹		2		WA	120
rs190877400^1,2		--	6587631(+)	`GGACTC/TATGTT`	2	--	ds500¹		0	--	--	--	--
rs116772780^1,2	F,	--	6587638(+)	`TGTTTG/TGAGAT`	2	--	ds500¹		1		WA	118
rs57791721^1,2	C,	--	6587649(+)	`CTTCCC/GTTGGC`	2	--	ds500¹		2		WA	120
rs183388416^1,2		--	6587657(+)	`GGCATA/GGACTT`	2	--	ds500¹		0	--	--	--	--
rs116540819^1,2	F,	--	6587660(+)	`ATGGAC/TTTGCT`	2	--	ds500¹		1		WA	118
rs145117381^1,2		--	6587793(+)	`TGTGAA/CTTTGG`	2	--	ds500¹		0	--	--	--	--
rs147145493^1,2		--	6587861(+)	`TAACAC/GCTTCC`	2	--	ds500¹		0	--	--	--	--
rs201004816^1,2		--	6587875(+)	`TCACA-/GGGGTT`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC13A5 (6588032 - 6616886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC13A5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC13A5

DNA2.0 Custom Variant and Variant Library Synthesis for SLC13A5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC13A5 for disorders           About GeneDecksing

OMIM gene information: 608305    OMIM disorders: --

4 diseases for SLC13A5:    About MalaCards

colon carcinoma pharyngitis cholesterol carcinoma

Human Genome Epidemiology (HuGE) Navigator: SLC13A5 (1 document)

Export disorders for SLC13A5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC13A5 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with SLC13A5)

Utopia: connect your pdf to the dynamic
world of online information

Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function. (PubMed id 12445824)^{1, 2, 3, 9} Inoue K.... Ganapathy V. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. (PubMed id 12826022)^{1, 9} Inoue K....Ganapathy V. (2003)
The genetic architecture of economic and political pre ferences. (PubMed id 22566634)¹ Benjamin D.J....Visscher P.M. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. (PubMed id 16973915)¹ Gopal E....Ganapathy V. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. (PubMed id 16211368)¹ Pajor A.M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284111	HGNC: 23089	AceView: SLC13A5	Ensembl:ENSG00000141485	euGenes: HUgn284111
ECgene: SLC13A5	H-InvDB: SLC13A5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC13A5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC13A5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC13A5 gene:
Search GeneIP for patents involving SLC13A5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SLC13A5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC13A5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC13A5
	OriGene Protein Over-expression Lysate for SLC13A5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SLC13A5		OriGene 3'-UTR Clone for SLC13A5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC13A5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC13A5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLC13A5		OriGene Custom Protein Services for SLC13A5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC13A5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC13A5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC13A5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC13A5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC13A5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC13A5

	GenScript Custom Purified and Recombinant Proteins Services for SLC13A5		GenScript cDNA clones with any tag delivered in your preferred vector for SLC13A5
	GenScript Custom Assay Services for SLC13A5		GenScript Custom Superior Antibodies Services for SLC13A5
	GenScript Custom overexpressing Cell Line Services for SLC13A5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SLC13A5 promoter
	Search Chromatin IP Primers for SLC13A5
	RT² qPCR Primer Assay in human, mouse, rat SLC13A5
	Search GNC Networks for SLC13A5
	SABiosciences Custom PCR Arrays for SLC13A5

Search Tocris compounds for SLC13A5

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLC13A5 antibodies
	SLC13A5 proteins

	Search for Antibodies for SLC13A5 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SLC13A5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLC13A5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLC13A5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A5

	SwitchGear 3'UTR luciferase reporter plasmids for SLC13A5
	SwitchGear Promoter luciferase reporter plasmids for SLC13A5

ThermoFisher Antibodies for SLC13A5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC13A5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLC13A5 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SLC13A5 Gene

solute carrier family 13 (sodium-dependent citrate transporter),...

Aliases
for SLC13A5 gene

Summaries
for SLC13A5 gene

Genomic Views
for SLC13A5 gene

Proteins
for SLC13A5 gene

Protein Domains /
Families
for SLC13A5 gene

Function
for SLC13A5 gene

Pathways & Interactions
for SLC13A5 gene

Drugs & Compounds
for SLC13A5 gene

Transcripts
for SLC13A5 gene

Expression
for SLC13A5 gene

Orthologs
for SLC13A5 gene

Paralogs
for SLC13A5 gene

Genomic Variants
for SLC13A5 gene

Disorders / Diseases
for SLC13A5 gene

Publications
for SLC13A5 gene

External Searches for SLC13A5 gene

Genome Databases showing SLC13A5 gene

Other Databases showing SLC13A5 gene

Specialized Databases showing SLC13A5 gene

Intellectual Property
for SLC13A5 gene

Products
for SLC13A5 gene

View Random Gene

Advanced Search

Export list of displayed genes

SLC13A5 Gene

solute carrier family 13 (sodium-dependent citrate transporter),...

Aliasesfor SLC13A5 gene

Summariesfor SLC13A5 gene

Genomic Viewsfor SLC13A5 gene

Proteinsfor SLC13A5 gene

Protein Domains /Familiesfor SLC13A5 gene

Functionfor SLC13A5 gene

Pathways & Interactionsfor SLC13A5 gene

Drugs & Compoundsfor SLC13A5 gene

Transcriptsfor SLC13A5 gene

Expression for SLC13A5 gene

Orthologsfor SLC13A5 gene

Paralogsfor SLC13A5 gene

Genomic Variantsfor SLC13A5 gene

Disorders / Diseasesfor SLC13A5 gene

Publicationsfor SLC13A5 gene

External Searches for SLC13A5 gene

Genome Databases showing SLC13A5 gene

Other Databases showing SLC13A5 gene

Specialized Databases showing SLC13A5 gene

Intellectual Propertyfor SLC13A5 gene

Productsfor SLC13A5 gene

View Random Gene

Aliases
for SLC13A5 gene

Summaries
for SLC13A5 gene

Genomic Views
for SLC13A5 gene

Proteins
for SLC13A5 gene

Protein Domains /
Families
for SLC13A5 gene

Function
for SLC13A5 gene

Pathways & Interactions
for SLC13A5 gene

Drugs & Compounds
for SLC13A5 gene

Transcripts
for SLC13A5 gene

Expression
for SLC13A5 gene

Orthologs
for SLC13A5 gene

Paralogs
for SLC13A5 gene

Genomic Variants
for SLC13A5 gene

Disorders / Diseases
for SLC13A5 gene

Publications
for SLC13A5 gene

Intellectual Property
for SLC13A5 gene

Products
for SLC13A5 gene