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Aliases for SLC13A5 Gene

Aliases for SLC13A5 Gene

  • Solute Carrier Family 13 (Sodium-Dependent Citrate Transporter), Member 5 2 3
  • NaCT 3 4 6
  • Na(+)/Citrate Cotransporter 3 4
  • Sodium-Dependent Dicarboxylate Transporter 3
  • Na+-Coupled Citrate Transporter Protein 3
  • Sodium-Dependent Citrate Transporter 4
  • Sodium-Coupled Citrate Transporter 4
  • Solute Carrier Family 13 Member 5 3
  • EIEE25 3
  • MIndy 3

External Ids for SLC13A5 Gene

Previous GeneCards Identifiers for SLC13A5 Gene

  • GC17M006532
  • GC17M006788
  • GC17M006529
  • GC17M006588
  • GC17M006483

Summaries for SLC13A5 Gene

Entrez Gene Summary for SLC13A5 Gene

  • This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

GeneCards Summary for SLC13A5 Gene

SLC13A5 (Solute Carrier Family 13 (Sodium-Dependent Citrate Transporter), Member 5) is a Protein Coding gene. Diseases associated with SLC13A5 include epileptic encephalopathy, early infantile, 25 and ohtahara syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. An important paralog of this gene is SLC13A4.

UniProtKB/Swiss-Prot for SLC13A5 Gene

  • High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A5 Gene

Genomics for SLC13A5 Gene

Regulatory Elements for SLC13A5 Gene

Genomic Location for SLC13A5 Gene

Start:
6,684,713 bp from pter
End:
6,713,567 bp from pter
Size:
28,855 bases
Orientation:
Minus strand

Genomic View for SLC13A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC13A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A5 Gene

Proteins for SLC13A5 Gene

  • Protein details for SLC13A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YT5-S13A5_HUMAN
    Recommended name:
    Solute carrier family 13 member 5
    Protein Accession:
    Q86YT5
    Secondary Accessions:
    • B3KXR0
    • B7Z4P2
    • B7ZLB4
    • F8W7N2
    • Q6ZMG1

    Protein attributes for SLC13A5 Gene

    Size:
    568 amino acids
    Molecular mass:
    63062 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC13A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC13A5 Gene

Proteomics data for SLC13A5 Gene at MOPED

Post-translational modifications for SLC13A5 Gene

  • Glycosylation at Asn562
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC13A5 Gene

Domains for SLC13A5 Gene

Protein Domains for SLC13A5 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86YT5

UniProtKB/Swiss-Prot:

S13A5_HUMAN :
  • Q86YT5
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A5: view

Function for SLC13A5 Gene

Molecular function for SLC13A5 Gene

UniProtKB/Swiss-Prot Function: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.

Gene Ontology (GO) - Molecular Function for SLC13A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005343 organic acid:sodium symporter activity --
GO:0015137 citrate transmembrane transporter activity IEA --
GO:0015141 succinate transmembrane transporter activity IEA --
GO:0015142 tricarboxylic acid transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC13A5: view
genes like me logo Genes that share phenotypes with SLC13A5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC13A5 Gene

Localization for SLC13A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC13A5 Gene COMPARTMENTS Subcellular localization image for SLC13A5 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC13A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC13A5: view

Pathways for SLC13A5 Gene

genes like me logo Genes that share pathways with SLC13A5: view

Interacting Proteins for SLC13A5 Gene

Gene Ontology (GO) - Biological Process for SLC13A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
GO:0006842 tricarboxylic acid transport --
GO:0015744 succinate transport --
GO:0015746 citrate transport IEA --
GO:0035674 tricarboxylic acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC13A5: view

Compounds for SLC13A5 Gene

(1) HMDB Compounds for SLC13A5 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC13A5: view

Transcripts for SLC13A5 Gene

Unigene Clusters for SLC13A5 Gene

Solute carrier family 13 (sodium-dependent citrate transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7: - - -
SP8:

Relevant External Links for SLC13A5 Gene

GeneLoc Exon Structure for
SLC13A5
ECgene alternative splicing isoforms for
SLC13A5

Expression for SLC13A5 Gene

mRNA expression in normal human tissues for SLC13A5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC13A5 Gene

This gene is overexpressed in Liver (47.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC13A5 Gene

SOURCE GeneReport for Unigene cluster for SLC13A5 Gene Hs.399496

mRNA Expression by UniProt/SwissProt for SLC13A5 Gene

Q86YT5-S13A5_HUMAN
Tissue specificity: Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis.
genes like me logo Genes that share expressions with SLC13A5: view

Orthologs for SLC13A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC13A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC13A5 35
  • 99.18 (n)
  • 99.38 (a)
SLC13A5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC13A5 35
  • 87.31 (n)
  • 82.52 (a)
SLC13A5 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC13A5 35
  • 85.92 (n)
  • 84.86 (a)
SLC13A5 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc13a5 35
  • 80.11 (n)
  • 75 (a)
Slc13a5 16
Slc13a5 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC13A5 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A5 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc13a5 35
  • 81.46 (n)
  • 77.82 (a)
chicken
(Gallus gallus)
Aves SLC13A5 35
  • 65.04 (n)
  • 65.82 (a)
SLC13A5 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC13A5 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc13a5 35
  • 65.13 (n)
  • 65.72 (a)
zebrafish
(Danio rerio)
Actinopterygii slc13a5a 35
  • 65.25 (n)
  • 63.23 (a)
slc13a5a 36
  • 60 (a)
OneToMany
slc13a5b 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Indy 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nac-1 36
  • 38 (a)
ManyToMany
nac-3 36
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO91 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7160 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for SLC13A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A5 Gene

ENSEMBL:
Gene Tree for SLC13A5 (if available)
TreeFam:
Gene Tree for SLC13A5 (if available)

Paralogs for SLC13A5 Gene

Paralogs for SLC13A5 Gene

genes like me logo Genes that share paralogs with SLC13A5: view

Variants for SLC13A5 Gene

Sequence variations from dbSNP and Humsavar for SLC13A5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs170149 -- 6,692,611(+) CCTAC(A/G)CTGCT intron-variant
rs172642 -- 6,692,079(+) CTGGC(A/C)TAACA intron-variant
rs183379 -- 6,705,183(+) AAGCC(C/T)GGGAC intron-variant
rs184294 -- 6,698,784(+) TGTAA(C/T)GCCAG intron-variant
rs184295 -- 6,700,347(+) CAGAG(A/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC13A5 Gene

Variant ID Type Subtype PubMed ID
nsv907630 CNV Gain 21882294
nsv907631 CNV Loss 21882294

Relevant External Links for SLC13A5 Gene

HapMap Linkage Disequilibrium report
SLC13A5
Human Gene Mutation Database (HGMD)
SLC13A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC13A5 Gene

Disorders for SLC13A5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLC13A5 Gene including...

Search for SLC13A5 Gene in MalaCards »

Relevant External Links for SLC13A5

Genetic Association Database (GAD)
SLC13A5
Human Genome Epidemiology (HuGE) Navigator
SLC13A5
genes like me logo Genes that share disorders with SLC13A5: view

No data available for UniProtKB/Swiss-Prot for SLC13A5 Gene

Publications for SLC13A5 Gene

  1. Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function. (PMID: 12445824) Inoue K. … Ganapathy V. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23
  2. Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. (PMID: 12826022) Inoue K. … Ganapathy V. (Biochem. J. 2003) 3 23
  3. Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. (PMID: 18194662) Weerachayaphorn J. … Pajor A.M. (Biochim. Biophys. Acta 2008) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC13A5 Gene

Sources for SLC13A5 Gene

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