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Aliases for SLC13A4 Gene

Aliases for SLC13A4 Gene

  • Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 4 2 3
  • Solute Carrier Family 13 (Sodium/Sulphate Symporters), Member 4 2 3
  • Na(+)/Sulfate Cotransporter SUT-1 3 4
  • Sulphate Transporter 1 2 3
  • NaS2 3 4
  • SUT1 3 4
  • Solute Carrier Family 13 (Sodium/Sulfate Symporters), Member 4 3
  • SUT-1 3

External Ids for SLC13A4 Gene

Previous GeneCards Identifiers for SLC13A4 Gene

  • GC07M133708
  • GC07M134768
  • GC07M134782
  • GC07M134823
  • GC07M135016
  • GC07M135365
  • GC07M129668

Summaries for SLC13A4 Gene

GeneCards Summary for SLC13A4 Gene

SLC13A4 (Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and sodium:sulfate symporter activity. An important paralog of this gene is SLC13A3.

UniProtKB/Swiss-Prot for SLC13A4 Gene

  • Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A4 Gene

Genomics for SLC13A4 Gene

Regulatory Elements for SLC13A4 Gene

Genomic Location for SLC13A4 Gene

Chromosome:
7
Start:
135,681,231 bp from pter
End:
135,729,258 bp from pter
Size:
48,028 bases
Orientation:
Minus strand

Genomic View for SLC13A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC13A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A4 Gene

Proteins for SLC13A4 Gene

  • Protein details for SLC13A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKG4-S13A4_HUMAN
    Recommended name:
    Solute carrier family 13 member 4
    Protein Accession:
    Q9UKG4
    Secondary Accessions:
    • A4D1Q4
    • Q8N631

    Protein attributes for SLC13A4 Gene

    Size:
    626 amino acids
    Molecular mass:
    69358 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS)

neXtProt entry for SLC13A4 Gene

Proteomics data for SLC13A4 Gene at MOPED

Post-translational modifications for SLC13A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC13A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC13A4

No data available for DME Specific Peptides for SLC13A4 Gene

Domains & Families for SLC13A4 Gene

Gene Families for SLC13A4 Gene

Protein Domains for SLC13A4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC13A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKG4

UniProtKB/Swiss-Prot:

S13A4_HUMAN :
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A4: view

Function for SLC13A4 Gene

Molecular function for SLC13A4 Gene

UniProtKB/Swiss-Prot Function:
Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).

Gene Ontology (GO) - Molecular Function for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015382 sodium:sulfate symporter activity TAS 10535998
genes like me logo Genes that share ontologies with SLC13A4: view
genes like me logo Genes that share phenotypes with SLC13A4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC13A4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC13A4 Gene

Localization for SLC13A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC13A4 Gene COMPARTMENTS Subcellular localization image for SLC13A4 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10535998
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC13A4: view

Pathways & Interactions for SLC13A4 Gene

genes like me logo Genes that share pathways with SLC13A4: view

Interacting Proteins for SLC13A4 Gene

Gene Ontology (GO) - Biological Process for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport --
GO:0008272 sulfate transport TAS 10535998
GO:0035725 sodium ion transmembrane transport TAS 10535998
GO:0055085 transmembrane transport TAS --
GO:0098656 anion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC13A4: view

No data available for SIGNOR curated interactions for SLC13A4 Gene

Drugs & Compounds for SLC13A4 Gene

(1) Drugs for SLC13A4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 41

(2) Additional Compounds for SLC13A4 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC13A4: view

Transcripts for SLC13A4 Gene

Unigene Clusters for SLC13A4 Gene

Solute carrier family 13 (sodium/sulfate symporters), member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC13A4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3: - - -
SP4: - -

Relevant External Links for SLC13A4 Gene

GeneLoc Exon Structure for
SLC13A4
ECgene alternative splicing isoforms for
SLC13A4

Expression for SLC13A4 Gene

mRNA expression in normal human tissues for SLC13A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A4 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5), Testis (x5.3), and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for SLC13A4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC13A4 Gene



SOURCE GeneReport for Unigene cluster for SLC13A4 Gene Hs.490241

mRNA Expression by UniProt/SwissProt for SLC13A4 Gene

Q9UKG4-S13A4_HUMAN
Tissue specificity: Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.
genes like me logo Genes that share expression patterns with SLC13A4: view

Protein tissue co-expression partners for SLC13A4 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC13A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC13A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC13A4 35
  • 89.55 (n)
  • 90.72 (a)
SLC13A4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC13A4 35
  • 90.88 (n)
  • 92.96 (a)
SLC13A4 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc13a4 35
  • 86.55 (n)
  • 89.55 (a)
Slc13a4 16
Slc13a4 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC13A4 35
  • 99.41 (n)
  • 99.68 (a)
SLC13A4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc13a4 35
  • 87.78 (n)
  • 90.2 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC13A4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A4 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC13A4 35
  • 76.58 (n)
  • 80.74 (a)
SLC13A4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC13A4 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495139 35
  • 72.29 (n)
  • 71.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53521 35
zebrafish
(Danio rerio)
Actinopterygii slc13a4 35
  • 69.37 (n)
  • 71.71 (a)
slc13a4 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33934 36
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F31F6.6 37
  • 33 (a)
nac-1 36
  • 34 (a)
ManyToMany
nac-3 36
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for SLC13A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A4 Gene

ENSEMBL:
Gene Tree for SLC13A4 (if available)
TreeFam:
Gene Tree for SLC13A4 (if available)

Paralogs for SLC13A4 Gene

Paralogs for SLC13A4 Gene

(5) SIMAP similar genes for SLC13A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC13A4: view

Variants for SLC13A4 Gene

Sequence variations from dbSNP and Humsavar for SLC13A4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3110791 -- 135,683,080(+) GATCA(C/T)CTGAA intron-variant
rs3110792 -- 135,683,488(+) CCCCC(C/G)CTCAG intron-variant
rs3110801 -- 135,708,706(+) ATACA(C/T)ACTCA intron-variant
rs3110802 -- 135,708,947(+) TTTTG(G/T)GAGAT intron-variant
rs3110803 -- 135,709,018(+) TCCGC(C/T)TCCTG intron-variant

Variation tolerance for SLC13A4 Gene

Residual Variation Intolerance Score: 12.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC13A4 Gene

HapMap Linkage Disequilibrium report
SLC13A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC13A4 Gene

Disorders for SLC13A4 Gene

Relevant External Links for SLC13A4

Genetic Association Database (GAD)
SLC13A4
Human Genome Epidemiology (HuGE) Navigator
SLC13A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC13A4
genes like me logo Genes that share disorders with SLC13A4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC13A4 Gene

Publications for SLC13A4 Gene

  1. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. (PMID: 10535998) Girard J.-P. … Amalric F. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 23 67
  2. Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4). (PMID: 15607730) Markovich D. … Dawson P.A. (Biochem. Biophys. Res. Commun. 2005) 23 67
  3. Fusion to GFP blocks intercellular trafficking of the sucrose transporter SUT1 leading to accumulation in companion cells. (PMID: 14667250) Lalonde S. … Frommer W.B. (BMC Plant Biol. 2003) 23 67
  4. The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. (PMID: 11161786) Lee A. … Markovich D. (Genomics 2000) 23 67
  5. Molecular analysis of the human SLC13A4 sulfate transporter gene promoter. (PMID: 23485456) Jefferis J. … Dawson P.A. (Biochem. Biophys. Res. Commun. 2013) 67

Products for SLC13A4 Gene

Sources for SLC13A4 Gene

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