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Aliases for SLC13A4 Gene

Aliases for SLC13A4 Gene

  • Solute Carrier Family 13 Member 4 2 3
  • Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 4 2 3 5
  • Solute Carrier Family 13 (Sodium/Sulphate Symporters), Member 4 2 3
  • Na(+)/Sulfate Cotransporter SUT-1 3 4
  • Sulphate Transporter 1 2 3
  • NAS2 3 4
  • SUT1 3 4
  • Solute Carrier Family 13 (Sodium/Sulfate Symporters), Member 4 3
  • SUT-1 3

External Ids for SLC13A4 Gene

Previous GeneCards Identifiers for SLC13A4 Gene

  • GC07M133708
  • GC07M134768
  • GC07M134782
  • GC07M134823
  • GC07M135016
  • GC07M135365
  • GC07M129668

Summaries for SLC13A4 Gene

GeneCards Summary for SLC13A4 Gene

SLC13A4 (Solute Carrier Family 13 Member 4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and sodium:sulfate symporter activity. An important paralog of this gene is SLC13A3.

UniProtKB/Swiss-Prot for SLC13A4 Gene

  • Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A4 Gene

Genomics for SLC13A4 Gene

Regulatory Elements for SLC13A4 Gene

Enhancers for SLC13A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC13A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC13A4 Gene

135,681,231 bp from pter
135,729,258 bp from pter
48,028 bases
Minus strand

Genomic View for SLC13A4 Gene

Genes around SLC13A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC13A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC13A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A4 Gene

Proteins for SLC13A4 Gene

  • Protein details for SLC13A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 13 member 4
    Protein Accession:
    Secondary Accessions:
    • A4D1Q4
    • Q8N631

    Protein attributes for SLC13A4 Gene

    626 amino acids
    Molecular mass:
    69358 Da
    Quaternary structure:
    No Data Available
    • Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS).

neXtProt entry for SLC13A4 Gene

Proteomics data for SLC13A4 Gene at MOPED

Post-translational modifications for SLC13A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC13A4 Gene

No data available for DME Specific Peptides for SLC13A4 Gene

Domains & Families for SLC13A4 Gene

Gene Families for SLC13A4 Gene

Protein Domains for SLC13A4 Gene


Suggested Antigen Peptide Sequences for SLC13A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A4: view

Function for SLC13A4 Gene

Molecular function for SLC13A4 Gene

UniProtKB/Swiss-Prot Function:
Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).
genes like me logo Genes that share phenotypes with SLC13A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC13A4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC13A4 Gene

Localization for SLC13A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC13A4 Gene COMPARTMENTS Subcellular localization image for SLC13A4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC13A4: view

Drugs & Compounds for SLC13A4 Gene

(1) Drugs for SLC13A4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 44

(2) Additional Compounds for SLC13A4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC13A4: view

Transcripts for SLC13A4 Gene

Unigene Clusters for SLC13A4 Gene

Solute carrier family 13 (sodium/sulfate symporters), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP3: - - -
SP4: - -

Relevant External Links for SLC13A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC13A4 Gene

mRNA expression in normal human tissues for SLC13A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A4 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5), Testis (x5.3), and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for SLC13A4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC13A4 Gene

SOURCE GeneReport for Unigene cluster for SLC13A4 Gene Hs.490241

mRNA Expression by UniProt/SwissProt for SLC13A4 Gene

Tissue specificity: Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.
genes like me logo Genes that share expression patterns with SLC13A4: view

Protein tissue co-expression partners for SLC13A4 Gene

Primer Products

Orthologs for SLC13A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC13A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC13A4 35
  • 89.55 (n)
  • 90.72 (a)
SLC13A4 36
  • 91 (a)
(Canis familiaris)
Mammalia SLC13A4 35
  • 90.88 (n)
  • 92.96 (a)
SLC13A4 36
  • 85 (a)
(Mus musculus)
Mammalia Slc13a4 35
  • 86.55 (n)
  • 89.55 (a)
Slc13a4 16
Slc13a4 36
  • 89 (a)
(Pan troglodytes)
Mammalia SLC13A4 35
  • 99.41 (n)
  • 99.68 (a)
SLC13A4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc13a4 35
  • 87.78 (n)
  • 90.2 (a)
(Monodelphis domestica)
Mammalia SLC13A4 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SLC13A4 36
  • 79 (a)
(Gallus gallus)
Aves SLC13A4 35
  • 76.58 (n)
  • 80.74 (a)
SLC13A4 36
  • 78 (a)
(Anolis carolinensis)
Reptilia SLC13A4 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495139 35
  • 72.29 (n)
  • 71.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53521 35
(Danio rerio)
Actinopterygii slc13a4 35
  • 69.37 (n)
  • 71.71 (a)
slc13a4 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33934 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F31F6.6 37
  • 33 (a)
nac-1 36
  • 34 (a)
nac-3 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
-- 36
  • 36 (a)
Species with no ortholog for SLC13A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A4 Gene

Gene Tree for SLC13A4 (if available)
Gene Tree for SLC13A4 (if available)

Paralogs for SLC13A4 Gene

Paralogs for SLC13A4 Gene

(5) SIMAP similar genes for SLC13A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC13A4: view

Variants for SLC13A4 Gene

Sequence variations from dbSNP and Humsavar for SLC13A4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_057193 -
rs6948713 -- 135,721,156(+) CAAGT(A/G)AGGCT intron-variant
rs6977150 -- 135,719,803(+) TGTGT(A/G)TGTGT intron-variant
rs13246120 -- 135,681,138(+) ACCTA(G/T)TGAGT downstream-variant-500B
rs28399795 -- 135,715,107(+) TGAGC(A/C/G)TGTAT intron-variant

Variation tolerance for SLC13A4 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SLC13A4 Gene

Disorders for SLC13A4 Gene

Relevant External Links for SLC13A4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC13A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC13A4 Gene

Publications for SLC13A4 Gene

  1. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. (PMID: 10535998) Girard J.-P. … Amalric F. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4). (PMID: 15607730) Markovich D. … Dawson P.A. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts. (PMID: 23453247) Simmons D.G. … Dawson P.A. (Placenta 2013) 3
  4. Molecular analysis of the human SLC13A4 sulfate transporter gene promoter. (PMID: 23485456) Jefferis J. … Dawson P.A. (Biochem. Biophys. Res. Commun. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for SLC13A4 Gene

Sources for SLC13A4 Gene