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Aliases for SLC13A4 Gene

Aliases for SLC13A4 Gene

  • Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 4 2 3
  • SUT1 3 4 6
  • Solute Carrier Family 13 (Sodium/Sulphate Symporters), Member 4 2 3
  • Na(+)/Sulfate Cotransporter SUT-1 3 4
  • Sulphate Transporter 1 2 3
  • NaS2 3 4
  • Solute Carrier Family 13 (Sodium/Sulfate Symporters), Member 4 3
  • Solute Carrier Family 13 Member 4 3
  • SUT-1 3

External Ids for SLC13A4 Gene

Previous GeneCards Identifiers for SLC13A4 Gene

  • GC07M133708
  • GC07M134768
  • GC07M134782
  • GC07M134823
  • GC07M135016
  • GC07M135365
  • GC07M129668

Summaries for SLC13A4 Gene

GeneCards Summary for SLC13A4 Gene

SLC13A4 (Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include sodium:sulfate symporter activity. An important paralog of this gene is SLC13A3.

UniProtKB/Swiss-Prot for SLC13A4 Gene

  • Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A4 Gene

Genomics for SLC13A4 Gene

Regulatory Elements for SLC13A4 Gene

Genomic Location for SLC13A4 Gene

Start:
135,681,231 bp from pter
End:
135,729,258 bp from pter
Size:
48,028 bases
Orientation:
Minus strand

Genomic View for SLC13A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC13A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A4 Gene

Proteins for SLC13A4 Gene

  • Protein details for SLC13A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKG4-S13A4_HUMAN
    Recommended name:
    Solute carrier family 13 member 4
    Protein Accession:
    Q9UKG4
    Secondary Accessions:
    • A4D1Q4
    • Q8N631

    Protein attributes for SLC13A4 Gene

    Size:
    626 amino acids
    Molecular mass:
    69358 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS)

neXtProt entry for SLC13A4 Gene

Proteomics data for SLC13A4 Gene at MOPED

Post-translational modifications for SLC13A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC13A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC13A4 Gene

Domains for SLC13A4 Gene

Protein Domains for SLC13A4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC13A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKG4

UniProtKB/Swiss-Prot:

S13A4_HUMAN :
  • Q9UKG4
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A4: view

Function for SLC13A4 Gene

Molecular function for SLC13A4 Gene

UniProtKB/Swiss-Prot Function: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).

Gene Ontology (GO) - Molecular Function for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015382 sodium:sulfate symporter activity TAS 10535998
genes like me logo Genes that share ontologies with SLC13A4: view

Phenotypes for SLC13A4 Gene

GenomeRNAi human phenotypes for SLC13A4:
genes like me logo Genes that share phenotypes with SLC13A4: view

Animal Model Products

CRISPR Products

miRNA for SLC13A4 Gene

miRTarBase miRNAs that target SLC13A4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC13A4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC13A4 Gene

Localization for SLC13A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC13A4 Gene COMPARTMENTS Subcellular localization image for SLC13A4 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10535998
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC13A4: view

Pathways for SLC13A4 Gene

genes like me logo Genes that share pathways with SLC13A4: view

Interacting Proteins for SLC13A4 Gene

Gene Ontology (GO) - Biological Process for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport --
GO:0008272 sulfate transport TAS 10535998
GO:0035725 sodium ion transmembrane transport TAS 10535998
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC13A4: view

Compounds for SLC13A4 Gene

(3) HMDB Compounds for SLC13A4 Gene

Compound Synonyms Cas Number PubMed IDs
Phenol
  • acide carbolique
108-95-2
Sodium
  • Sodium
7440-23-5
Sulfate
  • Sulfate (ion 2-)
14808-79-8

(1) Novoseek inferred chemical compound relationships for SLC13A4 Gene

Compound -log(P) Hits PubMed IDs
sulfate 61.7 7
genes like me logo Genes that share compounds with SLC13A4: view

Transcripts for SLC13A4 Gene

Unigene Clusters for SLC13A4 Gene

Solute carrier family 13 (sodium/sulfate symporters), member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC13A4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3: - - -
SP4: - -

Relevant External Links for SLC13A4 Gene

GeneLoc Exon Structure for
SLC13A4
ECgene alternative splicing isoforms for
SLC13A4

Expression for SLC13A4 Gene

mRNA expression in normal human tissues for SLC13A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A4 Gene

This gene is overexpressed in Brain - Cerebellum (7.5), Testis (5.3), and Esophagus - Mucosa (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC13A4 Gene

SOURCE GeneReport for Unigene cluster for SLC13A4 Gene Hs.490241

mRNA Expression by UniProt/SwissProt for SLC13A4 Gene

Q9UKG4-S13A4_HUMAN
Tissue specificity: Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.
genes like me logo Genes that share expressions with SLC13A4: view

In Situ Assay Products

Orthologs for SLC13A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC13A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC13A4 35
  • 99.41 (n)
  • 99.68 (a)
SLC13A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC13A4 35
  • 89.55 (n)
  • 90.72 (a)
SLC13A4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC13A4 35
  • 90.88 (n)
  • 92.96 (a)
SLC13A4 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc13a4 35
  • 86.55 (n)
  • 89.55 (a)
Slc13a4 16
Slc13a4 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC13A4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A4 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc13a4 35
  • 87.78 (n)
  • 90.2 (a)
chicken
(Gallus gallus)
Aves SLC13A4 35
  • 76.58 (n)
  • 80.74 (a)
SLC13A4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC13A4 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53521 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495139 35
  • 72.29 (n)
  • 71.96 (a)
zebrafish
(Danio rerio)
Actinopterygii slc13a4 35
  • 69.37 (n)
  • 71.71 (a)
slc13a4 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33934 36
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nac-1 36
  • 34 (a)
ManyToMany
nac-3 36
  • 34 (a)
ManyToMany
F31F6.6 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for SLC13A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A4 Gene

ENSEMBL:
Gene Tree for SLC13A4 (if available)
TreeFam:
Gene Tree for SLC13A4 (if available)

Paralogs for SLC13A4 Gene

Paralogs for SLC13A4 Gene

Selected SIMAP similar genes for SLC13A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC13A4: view

Variants for SLC13A4 Gene

Sequence variations from dbSNP and Humsavar for SLC13A4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1132590 -- 135,695,058(+) GCTTT(A/G)AGAGC intron-variant
rs1137839 -- 135,702,001(+) CCTTA(C/G)AGGAG intron-variant
rs1137840 -- 135,702,039(+) TAATG(A/G)AGAAC intron-variant
rs3110791 -- 135,683,080(+) GATCA(C/T)CTGAA intron-variant, downstream-variant-500B
rs3110792 -- 135,683,488(+) CCCCC(C/G)CTCAG intron-variant, utr-variant-3-prime

Relevant External Links for SLC13A4 Gene

HapMap Linkage Disequilibrium report
SLC13A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC13A4 Gene

Disorders for SLC13A4 Gene

Relevant External Links for SLC13A4

Genetic Association Database (GAD)
SLC13A4
Human Genome Epidemiology (HuGE) Navigator
SLC13A4
genes like me logo Genes that share disorders with SLC13A4: view

No data available for UniProtKB/Swiss-Prot for SLC13A4 Gene

Publications for SLC13A4 Gene

  1. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. (PMID: 10535998) Girard J.-P. … Amalric F. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4). (PMID: 15607730) Markovich D. … Dawson P.A. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. (PMID: 16211368) Pajor A.M. (Pflugers Arch. 2006) 3

Products for SLC13A4 Gene

Sources for SLC13A4 Gene

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