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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC13A3 Gene

protein-coding GIFtS: 57
GCID: GC20M045186

solute carrier family 13 (sodium-dependent dicarboxylate...

Explore 4 diseases affiliated with
SLC13A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 3¹ ²		Na(+)/Dicarboxylate Cotransporter 3² ³
NADC3¹ ² ³ ⁵		NaDC-3³
SDCT2¹ ² ³		Sodium-Dependent High Affinity Dicarboxylate Transporter 3²
Sodium-Dependent High-Affinity Dicarboxylate Transporter 2² ³		Solute Carrier Family 13 Member 3²
HNaDC3¹		NaDC-3³

External Ids:	HGNC: 14430¹	Entrez Gene: 64849²	Ensembl: ENSG00000158296⁷	OMIM: 606411⁵	UniProtKB: Q8WWT9³

Export aliases for SLC13A3 gene to outside databases

Previous GC identifers: GC20M044915 GC20M045824 GC20M045871 GC20M044619 GC20M041927

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC13A3:

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2

categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity

transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene

represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been

found for this gene, although the full-length nature of some of them have not been characterized yet. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S13A3_HUMAN, Q8WWT9

Function: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms.

The stoichiometry is probably 3 Na(+) for 1 divalent succinate

Gene Wiki entry for SLC13A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC13A3 gene promoter:
GR GR-beta STAT1beta STAT1alpha E47 Egr-4 Egr-2 POU2F1 POU2F1a GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC13A3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC13A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC13A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12

SLC13A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC13A3 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M045186: view genomic region (about GC identifiers)

Start:	45,186,462 bp from pter	End:	45,313,124 bp from pter
Size:	126,663 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S13A3_HUMAN, Q8WWT9 (See protein sequence)

Recommended Name: Solute carrier family 13 member 3

Size: 602 amino acids; 66841 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAF73251.1; Type=Frameshift; Positions=188, 199; Sequence=CAC09447.2; Type=Erroneous

initiation; Sequence=CAI42505.1; Type=Erroneous gene model prediction; Sequence=CAI42506.1; Type=Erroneous gene model

prediction; Sequence=CAI42507.1; Type=Erroneous gene model prediction;

Secondary accessions: B4DIR8 E1P5U4 Q5JYC9 Q5JYD0 Q5JYD1 Q5TCQ2 Q8IVB1 Q8N8K4 Q96MM5 Q9BR25 Q9H1G1

Q9H3W4 Q9NQN5 Q9NS04

Alternative splicing: 5 isoforms: Q8WWT9-1 Q8WWT9-2 Q8WWT9-3 Q8WWT9-4 Q8WWT9-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC13A3: NX_Q8WWT9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WWT9

SLC13A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001011554.1 NP_001180268.1 NP_001180269.1 NP_001180271.1 NP_073740.2

ENSEMBL proteins:

ENSP00000279027 ENSP00000420177 ENSP00000419621 ENSP00000417784 ENSP00000394217

ENSP00000395095 ENSP00000397955 ENSP00000415852 ENSP00000290317 ENSP00000379648

ENSP00000403394 ENSP00000361193 ENSP00000344912

Reactome Protein details: Q8WWT9
Human Recombinant Protein Products for SLC13A3:

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	Uscn Proteins for SLC13A3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005626	insoluble fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

SLC13A3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC13A3 for domains About GeneDecksing

1 InterPro domain/family:

IPR001898 Na/sul_symport

Graphical View of Domain Structure for InterPro Entry Q8WWT9

ProtoNet protein and cluster: Q8WWT9

1 Blocks protein family: IPB001898 Sodium/sulphate symporter

UniProtKB/Swiss-Prot: S13A3_HUMAN, Q8WWT9

Similarity: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S13A3_HUMAN, Q8WWT9

Function: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms.

The stoichiometry is probably 3 Na(+) for 1 divalent succinate

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	--	--
GO:0005310	dicarboxylic acid transmembrane transporter activity	--	--
GO:0005343	organic acid:sodium symporter activity	--	--
GO:0015137	citrate transmembrane transporter activity	--	--
GO:0015141	succinate transmembrane transporter activity	--	--

SLC13A3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLC13A3:

Increased number of cells in m

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Bile salt and organic anion SLC transporters

Bile salt and organic anion SLC transporters

1.00

Sodium-coupled sulphate, di- and tri-carboxylate transporters

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for SLC13A3

	Sodium-coupled sulphate, di- and tri-carboxylate transporters
	Bile salt and organic anion SLC transporters
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

SLC13A3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC13A3

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006814	sodium ion transport	--	--
GO:0006835	dicarboxylic acid transport	--	--
GO:0015744	succinate transport	--	--
GO:0015746	citrate transport	--	--
GO:0015810	aspartate transport	--	--

SLC13A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC13A3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC13A3

2 HMDB Compounds for SLC13A3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--
Succinic acid	1,2-Ethanedicarboxylate (see all 11)	110-15-6	--

1 DrugBank Compound for SLC13A3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Succinic acid	1,2-Ethanedicarboxylic acid (see all 8)	110-15-6	target	--	16524379 16735460 17526543 15944208 15561973

6 Novoseek chemical compound relationships for SLC13A3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dicarboxylate	88.4	10	15983172 (1), 16331647 (1), 17356845 (1), 17426067 (1) (see all 7)
glutaric acid	82.3	4	17356845 (2), 18365245 (2)
succinate	66	4	10794676 (2), 17395152 (1)
alpha-ketoglutarate	64	1	15561973 (1)
citrate	49.7	3	10794676 (1), 12812680 (1)
sodium	14.7	1	17395152 (1)

Search CenterWatch for drugs/clinical trials and news about SLC13A3 / S13A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC13A3 gene (5 alternative transcripts):

NM_001011554.2 NM_001193339.1 NM_001193340.1 NM_001193342.1 NM_022829.5

Unigene Cluster for SLC13A3:

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

Hs.655498 [show with all ESTs]

Unigene Representative Sequence: NM_001011554

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000279027(uc002xsf.2 uc010zxx.2 uc010zxw.2) ENST00000472148

ENST00000495082 ENST00000468915 ENST00000464518 ENST00000450298 ENST00000420568

ENST00000417157(uc002xsi.4) ENST00000413164 ENST00000290317(uc010ghn.2 uc002xsg.2 uc010gho.2)

ENST00000396360 ENST00000435032(uc002xse.2 uc010ghm.2 uc010zxv.2)

ENST00000372121 ENST00000339636

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		hsa-miR-15a hsa-miR-331-3p hsa-miR-503 hsa-miR-424 hsa-miR-186 hsa-miR-28-5p hsa-miR-195 hsa-miR-15b

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Additional cDNA sequence:

AF154121.1 AK056713.1 AK096658.1 AK123351.1 AK293902.1 AK295748.1 AK303709.1 AK310767.1

AK310960.1 AK315131.1 AL442082.1 AY072810.3 BC014931.1 BC035966.1

21 DOTS entries:

DT.453172 DT.95166469 DT.101965218 DT.40107818 DT.99939296 DT.120797018 DT.101979455 DT.100023265

DT.120797033 DT.91766786 DT.75101225 DT.120797029 DT.100823469 DT.97841940 DT.120796969 DT.95155506

DT.95241639 DT.75192664 DT.99951619 DT.100023266 DT.92019887

24/348 AceView cDNA sequences (see all 348):

BM905899 CF541051 BX281293 AY072810 BQ013528 AK096502 BM461920 AA767449

AA577319 AA490068 BM053137 Z45620 BU729785 BM554197 AW614324 AI758242

BM847243 BM674579 NM_033550 AI510701 BE048937 AI889233 CB163315 AI767571

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A3 (see all 18) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^
SP1:					-												-		-				-		-		-																				-
SP2:					-		-										-		-				-		-		-
SP3:																	-		-		-		-		-		-										-
SP4:																											-																				-
SP5:			-		-												-		-				-		-		-

ExUns:	14	^	15	^	16a	·	16b	^	17a	·	17b	·	17c	^	18	^	19a	·	19b	·	19c	^	20a	·	20b	·	20c	·	20d	·	20e	·	20f
SP1:	-				-		-		-						-		-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SLC13A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC13A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SLC13A3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Proximal Tubule

Proximal Tubule Cells

Kidney

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Kidney

Epithelial Tubule

Kidney

Proximal Tubule

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC13A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC13A3

SOURCE GeneReport for Unigene cluster: Hs.655498

UniProtKB/Swiss-Prot: S13A3_HUMAN, Q8WWT9

Tissue specificity: Expression is highest in kidney. Detected in placenta, brain, liver and pancreas

SABiosciences Custom PCR Arrays for SLC13A3

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC13A3 gene from 10/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slc13a3^{1 , 5}	solute carrier family 13 (sodium-dependent dicarboxylate more^{1, 5}	85.98(n)¹ 88.15(a)¹		2 (85.54 cM)⁵ 114644¹ NM_054055.2¹ NP_473396.1¹ 165405028⁵
chicken (Gallus gallus)	Aves	SLC13A3¹	solute carrier family 13 (sodium-dependent dicarboxylate more	74.92(n) 79.73(a)		770495 XM_003642481.1 XP_003642529.1
lizard (Anolis carolinensis)	Reptilia	SLC13A3⁶	--	74(a)	1 ↔ 1	4(144585717-144643004)
African clawed frog (Xenopus laevis)	Amphibia	BX850871.1²	--	74.22(n)		BX850871.1
zebrafish (Danio rerio)	Actinopterygii	slc13a3¹	solute carrier family 13 (sodium-dependent dicarboxylate more	65.91(n) 68.89(a)		405838 NM_212902.1 NP_998067.1
fruit fly (Drosophila melanogaster)	Insecta	Indy-2⁶ CG33934⁶ (see all 4)	--	33(a) 32(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3R(15868479-15874438) 3R(15868479-15874438)
worm (Caenorhabditis elegans)	Secernentea	F31F6.6³	Na+/sulphate co-transporter like	37(a) (best of 3)		X(14930379-14933500) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ATSDAT⁶	tonoplast dicarboxylate transporter	32(a)	1 → many	5(19287369-19290465)
rice (Oryza sativa)	Liliopsida	Os.15092²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	70.44(n)		AK105756.1
E. coli (Escherichia coli)	Gamma proteobacteria	yfbS⁶	predicted transporter	12(a)	possible ortholog	Chromosome(2407542-2409374)

ENSEMBL Gene Tree for SLC13A3 (if available)
TreeFam Gene Tree for SLC13A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SLC13A3 gene

SLC13A5² SLC13A4² SLC13A1² SLC13A2²

5 SIMAP similar genes for SLC13A3 using alignment to 6 protein entries: S13A3_HUMAN (see all proteins):

SLC13A5 DKFZp686E17257 SLC13A1 SLC13A2 SLC13A4

SLC13A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188700676^1,2	C	unknown	45188833(+)	`CTGTCC/TGCACC`	10	Q R	mis¹		0	--	--	--	--
rs1405565^1,2	C,F,A,H	--	45186029(+)	`GCTAGG/AATGCC`	5	--	ds500¹		18		EA NA WA CSA	593
rs1405566^1,2	C,F,A,H	--	45186056(+)	`AGAGAG/CACCTG`	5	--	ds500¹		17		NA WA CSA EA	517
rs75421546^1,2	F	--	45186078(+)	`GAAGAG/AGCAGA`	5	--	ds500¹		2		WA EA	238
rs1405567^1,2	C,F,O,A,H	--	45186122(+)	`CAGAGC/TACCCA`	5	--	ds500¹		105		NS EA NA PA EU CA WA CSA	6770
rs185493170^1,2		--	45186281(+)	`TAGTGC/TCACCT`	5	--	ds500¹		0	--	--	--	--
rs6094377^1,2	H	--	45186285(+)	`gccacC/Ttgctc`	5	--	ds500¹		4		NS EA	418
rs189921970^1,2		--	45186386(+)	`ATGACC/TTGTTT`	5	--	ds500¹		0	--	--	--	--
rs430114^1,2	C,H	--	45186397(-)	`AATAGG/AAACAT`	5	--	ds500¹		14		NA WA CSA EA	381
rs1405568^1,2	F,H	--	45186436(+)	`ccatgT/Agggcg`	5	--	ds500¹		5		NS EA WA	534

HapMap Linkage Disequilibrium report for SLC13A3 (45186462 - 45313124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SLC13A3
3 CNVs: 7308 3219 8887
3 Indels: 29525 60367 33352

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC13A3 for disorders           About GeneDecksing

OMIM gene information: 606411    OMIM disorders: --

4 diseases for SLC13A3:    About MalaCards

axenfeld-rieger syndrome diastrophic dysplasia canavan disease pharyngitis

2 diseases from the University of Copenhagen DISEASES database for SLC13A3:

Axenfeld-Rieger syndrome Diastrophic dysplasia

Human Genome Epidemiology (HuGE) Navigator: SLC13A3 (1 document)

Export disorders for SLC13A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC13A3 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with SLC13A3)

Utopia: connect your pdf to the dynamic
world of online information

Structure, function, and genomic organization of human Na(+)- dependent high-affinity dicarboxylate transporter. (PubMed id 10794676)^{1, 2, 3, 9} Wang H.... Ganapathy V. (2000)
Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. (PubMed id 15561973)^{1, 7, 9} Burckhardt B.C....Burckhardt G. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. (PubMed id 10992006)^{1, 3} Huang W....Ganapathy V. (2000)
Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter. (PubMed id 17426067)^{2, 9} Bai X.Y....Fu B. (2007)
Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PubMed id 18602983)^{1, 9} Bento J.L....Mychaleckyj J.C. (2008)
Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3. (PubMed id 16331647)^{1, 9} Bai X....Shi S. (2006)
Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney. (PubMed id 17526543)^{7, 9} Wolff N.A....Armstrong V.W. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64849	HGNC: 14430	AceView: SLC13A3andTP53RK	Ensembl:ENSG00000158296	euGenes: HUgn64849
ECgene: SLC13A3	H-InvDB: SLC13A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC13A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC13A3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC13A3 gene:
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GeneCards and IP:
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