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Aliases for SLC13A3 Gene

Aliases for SLC13A3 Gene

  • Solute Carrier Family 13 Member 3 2 3
  • Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 3 2 3 5
  • Sodium-Dependent High-Affinity Dicarboxylate Transporter 2 3 4
  • Na(+)/Dicarboxylate Cotransporter 3 3 4
  • NaDC-3 3 4
  • HNaDC3 3 4
  • NADC3 3 4
  • SDCT2 3 4
  • Sodium-Dependent High Affinity Dicarboxylate Transporter 3 3

External Ids for SLC13A3 Gene

Previous GeneCards Identifiers for SLC13A3 Gene

  • GC20M044915
  • GC20M045824
  • GC20M045871
  • GC20M044619
  • GC20M045186
  • GC20M041927

Summaries for SLC13A3 Gene

Entrez Gene Summary for SLC13A3 Gene

  • Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC13A3 Gene

SLC13A3 (Solute Carrier Family 13 Member 3) is a Protein Coding gene. Diseases associated with SLC13A3 include N-Acetylglutamate Synthase Deficiency. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and high-affinity sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC13A4.

UniProtKB/Swiss-Prot for SLC13A3 Gene

  • High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.

Gene Wiki entry for SLC13A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A3 Gene

Genomics for SLC13A3 Gene

Regulatory Elements for SLC13A3 Gene

Enhancers for SLC13A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC13A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC13A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC13A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC13A3 Gene

Chromosome:
20
Start:
46,557,823 bp from pter
End:
46,684,485 bp from pter
Size:
126,663 bases
Orientation:
Minus strand

Genomic View for SLC13A3 Gene

Genes around SLC13A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC13A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC13A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A3 Gene

Proteins for SLC13A3 Gene

  • Protein details for SLC13A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWT9-S13A3_HUMAN
    Recommended name:
    Solute carrier family 13 member 3
    Protein Accession:
    Q8WWT9
    Secondary Accessions:
    • B4DIR8
    • E1P5U4
    • F6WI18
    • Q5JYC9
    • Q5JYD0
    • Q5JYD1
    • Q5TCQ2
    • Q8IVB1
    • Q8N8K4
    • Q96MM5
    • Q9BR25
    • Q9H1G1
    • Q9H3W4
    • Q9NQN5
    • Q9NS04

    Protein attributes for SLC13A3 Gene

    Size:
    602 amino acids
    Molecular mass:
    66841 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF73251.1; Type=Frameshift; Positions=188, 199; Evidence={ECO:0000305}; Sequence=CAC09447.2; Type=Miscellaneous discrepancy; Note=erroneous CDS prediction.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC13A3 Gene

neXtProt entry for SLC13A3 Gene

Proteomics data for SLC13A3 Gene at MOPED

Post-translational modifications for SLC13A3 Gene

  • Glycosylation at Asn 586 and Asn 596
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC13A3 Gene

Domains & Families for SLC13A3 Gene

Gene Families for SLC13A3 Gene

Protein Domains for SLC13A3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WWT9

UniProtKB/Swiss-Prot:

S13A3_HUMAN :
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A3: view

Function for SLC13A3 Gene

Molecular function for SLC13A3 Gene

UniProtKB/Swiss-Prot Function:
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.

Gene Ontology (GO) - Molecular Function for SLC13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015137 citrate transmembrane transporter activity IBA --
GO:0017153 sodium:dicarboxylate symporter activity IBA --
genes like me logo Genes that share ontologies with SLC13A3: view
genes like me logo Genes that share phenotypes with SLC13A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC13A3

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC13A3 Gene

Localization for SLC13A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC13A3 Gene COMPARTMENTS Subcellular localization image for SLC13A3 gene
Compartment Confidence
extracellular 5
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for SLC13A3 Gene

Pathways & Interactions for SLC13A3 Gene

genes like me logo Genes that share pathways with SLC13A3: view

Interacting Proteins for SLC13A3 Gene

Gene Ontology (GO) - Biological Process for SLC13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015810 aspartate transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC13A3: view

No data available for SIGNOR curated interactions for SLC13A3 Gene

Drugs & Compounds for SLC13A3 Gene

(3) Drugs for SLC13A3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0

(4) Additional Compounds for SLC13A3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC13A3: view

Transcripts for SLC13A3 Gene

Unigene Clusters for SLC13A3 Gene

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12: - -
SP13: - - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e · 20f
SP1: - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:
SP15: -
SP16: - -
SP17:
SP18:

Relevant External Links for SLC13A3 Gene

GeneLoc Exon Structure for
SLC13A3
ECgene alternative splicing isoforms for
SLC13A3

Expression for SLC13A3 Gene

mRNA expression in normal human tissues for SLC13A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A3 Gene

This gene is overexpressed in Kidney - Cortex (x30.9).

Protein differential expression in normal tissues from HIPED for SLC13A3 Gene

This gene is overexpressed in Kidney (33.6), Urine (19.2), and Platelet (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC13A3 Gene



SOURCE GeneReport for Unigene cluster for SLC13A3 Gene Hs.655498

mRNA Expression by UniProt/SwissProt for SLC13A3 Gene

Q8WWT9-S13A3_HUMAN
Tissue specificity: Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.
genes like me logo Genes that share expression patterns with SLC13A3: view

Protein tissue co-expression partners for SLC13A3 Gene

Primer Products

Orthologs for SLC13A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC13A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC13A3 35
  • 88.76 (n)
  • 88.87 (a)
SLC13A3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC13A3 35
  • 89.85 (n)
  • 90.52 (a)
SLC13A3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc13a3 35
  • 85.98 (n)
  • 88.15 (a)
Slc13a3 16
Slc13a3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC13A3 35
  • 99.45 (n)
  • 99.83 (a)
SLC13A3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc13a3 35
  • 86.83 (n)
  • 87.83 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC13A3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A3 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC13A3 35
  • 74.97 (n)
  • 79.97 (a)
SLC13A3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC13A3 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc13a3 35
  • 66.28 (n)
  • 69.36 (a)
zebrafish
(Danio rerio)
Actinopterygii slc13a3 35
  • 66.08 (n)
  • 69.2 (a)
slc13a3 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7309 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea B0285.6 37
  • 34 (a)
F31F6.6 37
  • 37 (a)
R107.1 37
  • 33 (a)
nac-2 35
  • 45.89 (n)
  • 39.81 (a)
nac-1 36
  • 36 (a)
ManyToMany
nac-3 36
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO87 38
rice
(Oryza sativa)
Liliopsida Os.15092 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for SLC13A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A3 Gene

ENSEMBL:
Gene Tree for SLC13A3 (if available)
TreeFam:
Gene Tree for SLC13A3 (if available)

Paralogs for SLC13A3 Gene

Paralogs for SLC13A3 Gene

(5) SIMAP similar genes for SLC13A3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC13A3: view

Variants for SLC13A3 Gene

Sequence variations from dbSNP and Humsavar for SLC13A3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3583 -- 46,557,891(+) CAAAA(C/T)AGACC utr-variant-3-prime
rs3585 -- 46,557,940(+) GAGCA(C/G)attca utr-variant-3-prime
rs8149 -- 46,558,602(+) TGCTC(A/G)CTTGG utr-variant-3-prime
rs9873 -- 46,681,999(+) tcagt(C/T)tccaa intron-variant
rs10218 -- 46,558,866(-) CTCAG(G/T)CCCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC13A3 Gene

Variant ID Type Subtype PubMed ID
nsv833994 CNV Gain 17160897
esv2722460 CNV Deletion 23290073
esv2722462 CNV Deletion 23290073
nsv912900 CNV Loss 21882294
esv34663 CNV Gain 17911159
nsv509771 CNV Insertion 20534489
esv6676 CNV Gain 19470904
nsv828733 CNV Gain 20364138
dgv1331e1 CNV Complex 17122850
nsv9812 CNV Gain 18304495
esv32661 CNV Gain 17666407
esv2722463 CNV Deletion 23290073
nsv179106 CNV Loss 16902084
esv2722464 CNV Deletion 23290073
nsv179609 CNV Loss 16902084
nsv912901 CNV Loss 21882294

Variation tolerance for SLC13A3 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC13A3 Gene

Disorders for SLC13A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC13A3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
n-acetylglutamate synthase deficiency
  • n-acetylglutamate synthase
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC13A3

Genetic Association Database (GAD)
SLC13A3
Human Genome Epidemiology (HuGE) Navigator
SLC13A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC13A3
genes like me logo Genes that share disorders with SLC13A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC13A3 Gene

Publications for SLC13A3 Gene

  1. Structure, function, and genomic organization of human Na(+)- dependent high-affinity dicarboxylate transporter. (PMID: 10794676) Wang H. … Ganapathy V. (Am. J. Physiol. 2000) 2 3 4 23 67
  2. Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. (PMID: 15561973) Burckhardt B.C. … Burckhardt G. (Am. J. Physiol. Renal Physiol. 2005) 3 23 25 26
  3. Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney. (PMID: 17526543) Wolff N.A. … Armstrong V.W. (Nephrol. Dial. Transplant. 2007) 23 25 26
  4. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PMID: 18602983) Bento J.L. … Mychaleckyj J.C. (Genomics 2008) 3 23
  5. Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3. (PMID: 16331647) Bai X. … Shi S. (J. Cell. Physiol. 2006) 3 23

Products for SLC13A3 Gene

Sources for SLC13A3 Gene

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