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SLC13A2 Gene

protein-coding   GIFtS: 60
GCID: GC17P026800

Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate...

  See SLC13A2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter),
Member 21 2
     Na(+)/Dicarboxylate Cotransporter 12 3
NADC12 3 5     NaCT2
Renal Sodium/Dicarboxylate Cotransporter2 3     Na(+)-Coupled Citrate Transporter2
NaDC-12 3     Solute Carrier Family 13 Member 22
SDCT12 3     

External Ids:    HGNC: 109171   Entrez Gene: 90582   Ensembl: ENSG000000072167   OMIM: 6041485   UniProtKB: Q131833   

Export aliases for SLC13A2 gene to outside databases

Previous GC identifers: GC17P026645 GC17P028700 GC17P026652 GC17P026946 GC17P023824 GC17P023009


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC13A2 Gene:
SLC13A2 (solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2) is a protein-coding gene. Diseases associated with SLC13A2 include metabolic acidosis. GO annotations related to this gene include low affinity sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC13A5.

UniProtKB/Swiss-Prot: S13A2_HUMAN, Q13183
Function: Cotransport of sodium ions and dicarboxylates such as succinate and citrate

Gene Wiki entry for SLC13A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC13A2 gene promoter:
         Max1   Tal-1   GATA-3   MyoD   LUN-1   STAT5A   AP-4   E47   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC13A2 promoter sequence
   Search Chromatin IP Primers for SLC13A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC13A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17p13.2

SLC13A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC13A2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026800:  view genomic region     (about GC identifiers)

Start:
26,800,311 bp from pter      End:
26,824,799 bp from pter
Size:
24,489 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S13A2_HUMAN, Q13183 (See protein sequence)
Recommended Name: Solute carrier family 13 member 2  
Size: 592 amino acids; 64410 Da
Secondary accessions: B2RBI9 B4DPL1 E7ETH5 Q4VAR7
Alternative splicing: 2 isoforms:  Q13183-1   Q13183-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC13A2: NX_Q13183

Explore proteomics data for SLC13A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC13A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139447.1  NP_003975.1  

    ENSEMBL proteins: 
     ENSP00000392411   ENSP00000316202   ENSP00000463457   ENSP00000463421   ENSP00000464074  
     ENSP00000441935   ENSP00000440802  
    Reactome Protein details: Q13183

    SLC13A2 Human Recombinant Protein Products:

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    Novus Biologicals SLC13A2 Protein
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for SLC13A2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Na+/dicarboxylate cotransporter 1
    SLC13 family of sodium-dependent sulphate/carboxylate transporters

    1 InterPro protein domain:
     IPR001898 Na/sul_symport

    Graphical View of Domain Structure for InterPro Entry Q13183

    ProtoNet protein and cluster: Q13183

    1 Blocks protein domain: IPB001898 Sodium/sulphate symporter

    UniProtKB/Swiss-Prot: S13A2_HUMAN, Q13183
    Similarity: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily


    Find genes that share domains with SLC13A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S13A2_HUMAN, Q13183
    Function: Cotransport of sodium ions and dicarboxylates such as succinate and citrate

         Genatlas biochemistry entry for SLC13A2:
    solute carrier family 13,member A2,sodium dependent dicarboxylate transporter,located in proximal tubule,kidney

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0015361low affinity sodium:dicarboxylate symporter activity TAS8967342
         
    Find genes that share ontologies with SLC13A2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc13a2):
     homeostasis/metabolism  renal/urinary system 

    Find genes that share phenotypes with SLC13A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc13a2tm1Smch for SLC13A2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC13A2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC13A2

    miRNA
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    hsa-mir-124-3p (MIRT022335)

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    hsa-miR-485-5p hsa-miR-301b hsa-miR-148b hsa-miR-301a hsa-miR-3666 hsa-miR-152 hsa-miR-454 hsa-miR-4295
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S13A2_HUMAN, Q13183: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8967342
    GO:0016020membrane TAS8967342
    GO:0016021integral component of membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC13A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC13A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Sodium-coupled sulphate, di- and tri-carboxylate transporters0.00


    Find genes that share SuperPaths with SLC13A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC13A2
        Sodium-coupled sulphate, di- and tri-carboxylate transporters


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC13A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC13A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SLC13A2 (ENSP000003162024) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC20A1ENSP000002725424STRING: ENSP00000272542
    SLC20A2ENSP000003404654STRING: ENSP00000340465
    SLC13A3ENSP000002790274STRING: ENSP00000279027
    AIMP1ENSP000003781914STRING: ENSP00000378191
    CDK14ENSP000002657414STRING: ENSP00000265741
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8967342
    GO:0006814sodium ion transport ----
    GO:0006835dicarboxylic acid transport TAS8967342
    GO:0055085transmembrane transport TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC13A2 (S13A2)

    1 HMDB Compound for SLC13A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC13A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Succinic acid1,2-Ethanedicarboxylic acid (see all 8)110-15-6target--16735460 16030212 15561973 16188913

    9 Novoseek inferred chemical compound relationships for SLC13A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dicarboxylate 93.1 19 10360950 (2), 10446305 (2), 9668069 (2), 10548552 (2) (see all 14)
    flufenamate 84.7 1 8946005 (1)
    succinate 82.6 12 10446305 (2), 18194662 (2), 10360950 (1), 11399753 (1) (see all 10)
    citrate 76.9 13 14973148 (3), 18161988 (2), 8946005 (2), 11399753 (1) (see all 8)
    glutaric acid 70.5 1 8946005 (1)
    lithium 63.1 2 8946005 (1), 9668069 (1)
    sodium 55.2 6 10360950 (1), 11399753 (1), 18161988 (1), 15774465 (1) (see all 6)
    furosemide 39.7 1 8946005 (1)
    cysteine 23.2 7 10548552 (7)



    Find genes that share compounds with SLC13A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC13A2 gene (3 alternative transcripts): 
    NM_001145976.1  NM_001145975.1  NM_003984.3  

    Unigene Cluster for SLC13A2:

    Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
    Hs.102307  [show with all ESTs]
    Unigene Representative Sequence: NM_001145975
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444914(uc010wan.2) ENST00000314669(uc002hbh.3 uc010wao.2)
    ENST00000577903(uc010wal.1) ENST00000541739 ENST00000579281 ENST00000459818
    ENST00000545060 ENST00000537681(uc010wam.2 uc002hbi.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC13A2 (see all 11):
    hsa-miR-485-5p hsa-miR-301b hsa-miR-148b hsa-miR-301a hsa-miR-3666 hsa-miR-152 hsa-miR-454 hsa-miR-4295
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    Additional mRNA sequence: 

    AK091926.1 AK298388.1 AK303909.1 AK314684.1 BC096277.1 BC096278.1 BC096279.1 NR_027384.1 
    U26209.1 

    3 DOTS entries:

    DT.427910  DT.99999837  DT.100744154 

    16 AceView cDNA sequences:

    BX957019 CD617792 BX283772 AI057450 U26209 BE252472 BI761183 CD617795 
    AA603049 BM853859 AK091926 NM_003984 BX483660 BE256673 CK429895 AW024214 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                                                                                  
    SP2:                    -           -                                                                                 
    SP3:                                -                                                                                 
    SP4:                    -     -     -                                                                                 


    ECgene alternative splicing isoforms for SLC13A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC13A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCTCTGG
    SLC13A2 Expression
    About this image


    SLC13A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
    SLC13A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC13A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.102307
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC13A2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc13a21 , 5 solute carrier family 13 (sodium-dependent dicarboxylate more1, 5 80.54(n)1
    77.74(a)1
      11 (46.74 cM)5
    205001  NM_022411.31  NP_071856.11 
     783970875 
    chicken
    (Gallus gallus)
    Aves SLC13A21 solute carrier family 13 (sodium-dependent dicarboxylate more 65.44(n)
    65.21(a)
      427830  XM_425404.3  XP_425404.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC13A26
    solute carrier family 13 (sodium-dependent dicarbo...
    60(a)
    1 ↔ 1
    GL343470.1(529958-542376)
    African clawed frog
    (Xenopus laevis)
    Amphibia nadc2-A-prov2 sodium/dicarboxylate cotransporter NaDC-2 72.69(n)    U87318.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.42712 Danio rerio mRNA similar to solute carrier family 13, more 75.86(n)    BC044437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Indy-23
    Indy1
    transport sodium:dicarboxylate
    cotransporter3
    I'm not dead yet1
    34(a)3
    53.51(n)1
    40.98(a)1
      400491  NM_168778.21  NP_730363.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F31F6.63
    nac-11
    Na+/sulphate co-transporter like3
    nac-11
    38(a)
    (best of 3)3
    48.95(n)1
    44.07(a)1
      X(14930379-14933500)3
    1815851  NM_078072.31  NP_510473.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TDT1 TDT 49.23(n)
    40.62(a)
      834806  NM_124129.3  NP_199567.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04849001 Os09g0484900 51.79(n)
    39.78(a)
      4347418  NM_001070051.1  NP_001063516.1 


    ENSEMBL Gene Tree for SLC13A2 (if available)
    TreeFam Gene Tree for SLC13A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC13A2 gene
    SLC13A52  SLC13A42  SLC13A12  SLC13A32  
    5 SIMAP similar genes for SLC13A2 using alignment to 7 protein entries:     S13A2_HUMAN (see all proteins):
    SLC13A5    DKFZp686E17257    SLC13A3    SLC13A1    SLC13A4

    Find genes that share paralogs with SLC13A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC13A2 (see all 595)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005564781,2
    C--26798672(+) GGGCCC/TGGTTT 3 -- us2k10--------
    rs782855051,2
    C--26798702(+) GTGGC-/CTCTCCTT 3 -- cds1 us2k10--------
    rs739891181,2
    C,F--26798759(+) TCGGGG/ACATTG 3 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1865937011,2
    --26798832(+) GGGCAA/GGTGGC 3 -- us2k10--------
    rs285855431,2
    C,F--26798960(+) ATCCCT/CCTGAC 3 -- us2k15Minor allele frequency- C:0.15NA WA 126
    rs1450235661,2
    --26799108(+) CCCCCA/GCAAAT 3 -- us2k10--------
    rs1907496941,2
    --26799128(+) AACCAC/TGCAGA 3 -- us2k10--------
    rs1151695741,2
    F--26799245(+) GGATCA/GTCATA 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs801995251,2
    C,F--26799402(+) ACACAC/TACACA 3 -- us2k12Minor allele frequency- T:0.45CSA WA 120
    rs1477479881,2
    --26799408(+) ACACAC/TGCATG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC13A2 (26800311 - 26824799 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC13A2: --
    Human Gene Mutation Database (HGMD): SLC13A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC13A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC13A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604148    OMIM disorders: --

    1 disease for SLC13A2:    
    About MalaCards
    metabolic acidosis

    2 diseases from the University of Copenhagen DISEASES database for SLC13A2:
    Nephrolithiasis     Diastrophic dysplasia

    Find genes that share disorders with SLC13A2           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLC13A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metabolic acidosis 40.1 1 10446305 (1)

    Genetic Association Database (GAD): SLC13A2
    Human Genome Epidemiology (HuGE) Navigator: SLC13A2 (2 documents)

    Export disorders for SLC13A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC13A2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SLC13A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls. (PubMed id 17470169)1, 2, 4, 9 Okamoto N....Kitamura T. (Int. J. Urol. 2007)
    2. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. (PubMed id 8967342)1, 2, 3, 9 Pajor A.M. (Am. J. Physiol. 1996)
    3. Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1--&gt;q11.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PubMed id 10343111)1, 3, 9 Mann S.S....Holmes R.P. (Cytogenet. Cell Genet. 1999)
    4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study. (PubMed id 15620109)1, 9 Bai X....Peng L. (Sci. China, C, Life Sci. 2004)
    8. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. (PubMed id 18161988)1, 9 Weerachayaphorn J. and Pajor A.M. (Biochemistry 2008)
    9. Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter. (PubMed id 15774465)1, 9 Pajor A.M. and Randolph K.M. (J. Biol. Chem. 2005)
    10. Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. (PubMed id 15561973)7, 9 Burckhardt B.C....Burckhardt G. (Am. J. Physiol. Renal Physiol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9058 HGNC: 10917 AceView: SLC13A2 Ensembl:ENSG00000007216 euGenes: HUgn9058
    ECgene: SLC13A2 H-InvDB: SLC13A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC13A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC13A2 gene:
    Search GeneIP for patents involving SLC13A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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